| Document And Entity Information | Aug. 12, 2022 |
| Cover [Abstract] | |
| Document Type | 8-K |
| Amendment Flag | false |
| Current Fiscal Year End Date | --12-31 |
| Document Period End Date | Aug. 12, 2022 |
| Entity Registrant Name | PALISADE BIO, INC. |
| Entity Central Index Key | 0001357459 |
| Entity Emerging Growth Company | false |
| Entity File Number | 001-33672 |
| Entity Incorporation, State or Country Code | DE |
| Entity Tax Identification Number | 52-2007292 |
| Entity Address, Address Line One | 7750 El Camino Real |
| Entity Address, Address Line Two | Suite 5200 |
| Entity Address, City or Town | Carlsbad |
| Entity Address, State or Province | CA |
| Entity Address, Postal Zip Code | 92009 |
| City Area Code | (858) |
| Local Phone Number | 704-4900 |
| Entity Information, Former Legal or Registered Name | N/A |
| Written Communications | false |
| Soliciting Material | false |
| Pre-commencement Tender Offer | false |
| Pre-commencement Issuer Tender Offer | false |
| Title of 12(b) Security | Common Stock, $0.01 par value |
| Trading Symbol | PALI |
| Security Exchange Name | NONE |
