| Document and Entity Information | May 31, 2022 |
| Cover [Abstract] | |
| Document Type | 8-K |
| Amendment Flag | false |
| Document Period End Date | May 31, 2022 |
| Entity Registrant Name | Precision BioSciences, Inc. |
| Entity Central Index Key | 0001357874 |
| Entity Emerging Growth Company | true |
| Entity Ex Transition Period | false |
| Entity File Number | 001-38841 |
| Entity Incorporation, State or Country Code | DE |
| Entity Tax Identification Number | 20-4206017 |
| Entity Address, Address Line One | 302 East Pettigrew St. |
| Entity Address, Address Line Two | Suite A-100 |
| Entity Address, City or Town | Durham |
| Entity Address, State or Province | NC |
| Entity Address, Postal Zip Code | 27701 |
| City Area Code | 919 |
| Local Phone Number | 314-5512 |
| Written Communications | false |
| Soliciting Material | false |
| Pre-commencement Tender Offer | false |
| Pre-commencement Issuer Tender Offer | false |
| Title of 12(b) Security | Common stock, par value $0.000005 per share |
| Trading Symbol | DTIL |
| Security Exchange Name | NASDAQ |
