EyeGate Pharmaceuticals (EYEG) 10-K 25 Mar 24 2023 FY Annual report Financial data

Cover

Cover - USD ($)	12 Months Ended
	Dec. 31, 2023	Mar. 22, 2024	Jun. 30, 2023
Cover [Abstract]
Document Type	10-K
Document Annual Report	true
Document Period End Date	Dec. 31, 2023
Current Fiscal Year End Date	--12-31
Document Transition Report	false
Entity File Number	001-36672
Entity Registrant Name	KIORA PHARMACEUTICALS, INC
Entity Incorporation, State or Country Code	DE
Entity Tax Identification Number	98-0443284
Entity Address, Address Line One	332 Encinitas Blvd.
Entity Address, Address Line Two	Suite 102
Entity Address, City or Town	Encinitas
Entity Address, State or Province	CA
Entity Address, Postal Zip Code	92024
City Area Code	858
Local Phone Number	224-9600
Title of 12(b) Security	Common Stock, $0.01 par value
Trading Symbol	KPRX
Security Exchange Name	NASDAQ
Entity Well-known Seasoned Issuer	No
Entity Voluntary Filers	No
Entity Current Reporting Status	Yes
Entity Interactive Data Current	Yes
Entity Filer Category	Non-accelerated Filer
Entity Small Business	true
Entity Emerging Growth Company	false
ICFR Auditor Attestation Flag	false
Document Financial Statement Error Correction	false
Entity Shell Company	false
Entity Public Float			$ 4,762,870
Entity Common Stock, Shares Outstanding		26,256,197
Entity Central Index Key	0001372514
Document Fiscal Year Focus	2023
Document Fiscal Period Focus	FY
Amendment Flag	false

Audit Information

Audit Information	12 Months Ended
	Dec. 31, 2023
Audit Information [Abstract]
Auditor Firm ID	200
Auditor Name	HASKELL & WHITE LLP
Auditor Location	Irvine, California

CONSOLIDATED BALANCE SHEETS

CONSOLIDATED BALANCE SHEETS - USD ($)	Dec. 31, 2023	Dec. 31, 2022
Current Assets:
Cash and Cash Equivalents	$ 2,454,684	$ 5,964,556
Prepaid Expenses and Other Current Assets	233,382	343,069
Tax Receivables	2,049,965	1,373,041
Total Current Assets	4,738,031	7,680,666
Property and Equipment, Net	8,065	55,177
Restricted Cash	4,267	49,260
Intangible Assets and In-Process R&D, Net	8,813,850	10,743,164
Operating Lease Assets with Right-of-Use	106,890	116,992
Other Assets	40,767	33,000
Total Assets	13,711,870	18,678,259
Current Liabilities:
Accounts Payable	206,260	1,008,262
Accrued Expenses	1,380,666	1,835,934
Operating Lease Liabilities	47,069	105,782
Contingent Consideration, Short-Term	0	322,385
Total Current Liabilities	1,633,995	3,272,363
Non-Current Liabilities:
Contingent Consideration	5,128,959	3,309,175
Deferred Tax Liability	779,440	689,121
Non-Current Operating Lease Liabilities	59,822	0
Total Non-Current Liabilities	5,968,221	3,998,296
Total Liabilities	7,602,216	7,270,659
Commitments and Contingencies
Stockholders’ Equity:
Preferred Stock	4	0
Common Stock, $0.01 Par Value: 50,000,000 shares authorized at December 31, 2023 and 2022; 7,705,640 and 1,796,472 shares issued and outstanding at December 31, 2023 and 2022, respectively	77,078	17,986
Additional Paid-In Capital	153,192,228	146,035,314
Accumulated Deficit	(146,976,855)	(134,462,959)
Accumulated Other Comprehensive Loss	(182,801)	(182,741)
Total Stockholders’ Equity	6,109,654	11,407,600
Total Liabilities and Stockholders’ Equity	$ 13,711,870	$ 18,678,259

CONSOLIDATED BALANCE SHEETS (Pa

CONSOLIDATED BALANCE SHEETS (Parenthetical) - $ / shares	Dec. 31, 2023	Dec. 31, 2022
Preferred stock, par value (in usd per share)	$ 0.01	$ 0.01
Preferred stock, authorized (in shares)	10,000,000	10,000,000
Common stock, par value (in usd per share)	$ 0.01	$ 0.01
Common stock, authorized (in shares)	50,000,000	50,000,000
Common stock, issued (in shares)	7,705,640	1,796,472
Common stock, outstanding (in shares)	7,705,640	1,796,472
Series A Preferred Stock
Preferred stock, designated (in shares)	3,750	3,750
Preferred stock, issued (in shares)	0	0
Preferred stock, outstanding (in shares)	0	0
Series B Preferred Stock
Preferred stock, designated (in shares)	10,000	10,000
Preferred stock, issued (in shares)	0	0
Preferred stock, outstanding (in shares)	0	0
Series C Preferred Stock
Preferred stock, designated (in shares)	10,000	10,000
Preferred stock, issued (in shares)	0	0
Preferred stock, outstanding (in shares)	0	0
Series D Preferred Stock
Preferred stock, designated (in shares)	20,000	20,000
Preferred stock, issued (in shares)	7	7
Preferred stock, outstanding (in shares)	7	7
Series E Preferred Stock
Preferred stock, designated (in shares)	1,280	1,280
Preferred stock, issued (in shares)	0	0
Preferred stock, outstanding (in shares)	0	0
Series F Preferred Stock
Preferred stock, designated (in shares)	3,908	3,908
Preferred stock, issued (in shares)	420	0
Preferred stock, outstanding (in shares)	420	0

CONSOLIDATED STATEMENTS OF OPER

CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($)	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Operating Expenses:
General and Administrative	$ 4,663,146	$ 8,277,993
Research and Development	4,027,037	3,448,925
In-Process R&D Impairment	1,904,314	0
Change in Fair Value of Contingent Consideration	1,992,399	582,605
Total Operating Expenses	12,586,896	12,309,523
Operating Loss Before Other Income	(12,586,896)	(12,309,523)
Other Income (Expense), Net:
Change in Fair Value of Warrant Liability	0	(1,425,102)
(Loss) Gain on Disposal of Fixed Assets	(28,379)	4,211
Interest Income	173,989	56,891
Interest Expense	(11,132)	(8,599)
Other Income (Expense), Net	28,841	(14,498)
Total Other Income (Expense), Net	163,319	(1,387,097)
Loss Before Income Tax (Expense) Benefit	(12,423,577)	(13,696,620)
Income Tax (Expense) Benefit	(90,319)	113,010
Net Loss	(12,513,896)	(13,583,610)
Deemed Dividends from Warrant Reset Provision	(530,985)	0
Net Loss Attributable to Common Shareholders, basic	(13,044,881)	(13,583,610)
Net Loss Attributable to Common Shareholders, diluted	$ (13,044,881)	$ (13,583,610)
Net Loss per Common Share - Basic (in usd per share)	$ (2.69)	$ (18.55)
Net Loss per Common Share - Diluted (in usd per share)	$ (2.69)	$ (18.55)
Weighted Average Shares Outstanding - Basic (in shares)	4,842,067	732,303
Weighted Average Shares Outstanding - Diluted (in shares)	4,842,067	732,303
Other Comprehensive Loss:
Net Loss	$ (12,513,896)	$ (13,583,610)
Foreign Currency Translation Adjustments	(60)	(96,310)
Comprehensive Loss	$ (12,513,956)	$ (13,679,920)

CONSOLIDATED STATEMENTS OF STOC

CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($)	Total	Public Offering	Private Placement	Equity Line Of Credit	Series F Preferred Stock	Series F Preferred Stock Public Offering	Series E Preferred Stock	Preferred Stock	Preferred Stock Series F Preferred Stock	Preferred Stock Series F Preferred Stock Public Offering	Preferred Stock Series E Preferred Stock	Common Stock	Common Stock Public Offering	Common Stock Private Placement	Common Stock Equity Line Of Credit	Common Stock Series F Preferred Stock	Common Stock Series E Preferred Stock	Additional Paid-In Capital	Additional Paid-In Capital Public Offering	Additional Paid-In Capital Private Placement	Additional Paid-In Capital Equity Line Of Credit	Additional Paid-In Capital Series F Preferred Stock	Additional Paid-In Capital Series F Preferred Stock Public Offering	Additional Paid-In Capital Series E Preferred Stock	Accumulated Other Comprehensive Loss	Accumulated Deficit
Balance (in shares) at Dec. 31, 2021								7				316,599
Balance at Dec. 31, 2021	$ 14,579,048							$ 0				$ 3,166						$ 135,541,662							$ (86,431)	$ (120,879,349)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Stock-Based Compensation	462,450																	462,450
Issuance of Panoptes Holdback Shares (in shares)												10,087
Issuance of Panoptes Holdback Shares	0											$ 100						(100)
Issuance of Stock (in shares)											1,280		592,392
Issuance of Stock		$ 2,462,838					$ 665,191				$ 13		$ 5,924						$ 2,456,914					$ 665,178
Issuance of shares of common stock from warrant exercises (in shares)												65,000
Issuance of Shares of Common Stock from Warrant Exercises	520,000											$ 650						519,350
Conversion of Preferred Stock into Common Stock (in shares)											(1,280)						160,000
Conversion of Preferred Stock into Common Stock							$ 0				$ (13)						$ 1,600							$ (1,587)
Reclassification of Warrant Liability	3,674,791																	3,674,791
Cancellation of Reverse Stock Split Fractional Shares (in shares)												(2,215)
Cancellation of Reverse Stock Split Fractional Shares	(15,629)																	(15,629)
Issuance of Common Stock from Warrant Inducement, Net of Issuance Costs of $381,360 (in shares)												654,609
Issuance of Common Stock from Warrant Inducement, Net of Issuance Costs of $381,360	2,738,831											$ 6,546						2,732,285
Foreign Currency Translation Adjustment	(96,310)																								(96,310)
Net Loss	(13,583,610)																									(13,583,610)
Balance at Dec. 31, 2022	11,407,600							$ 0				$ 17,986						146,035,314							(182,741)	(134,462,959)
Balance (in shares) at Dec. 31, 2022								7				1,796,472
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Stock-Based Compensation	754,944																	754,944
Issuance of Stock (in shares)										3,908			2,197,628	52,798	125,000
Issuance of Stock		$ 1,018,455	$ 115,715	$ 442,310		$ 1,646,289				$ 39			$ 21,976	$ 528	$ 1,250				$ 996,479	$ 115,187	$ 441,060		$ 1,646,250
Issuance of Class C and D warrants from Public Offering, Net of Offering Costs of $381,877	2,931,218																	2,931,218
Issuance of shares of common stock from warrant exercises (in shares)												66,400
Issuance of Shares of Common Stock from Warrant Exercises	307,079											$ 664						306,415
Conversion of Preferred Stock into Common Stock (in shares)									(3,488)							3,170,592
Conversion of Preferred Stock into Common Stock					$ 0				$ (35)							$ 31,706						$ (31,671)
Issuance of Common Stock from Restricted Stock Awards (in shares)												296,750
Issuance of Common Stock from Restricted Stock Awards	0											$ 2,968						(2,968)
Foreign Currency Translation Adjustment	(60)																								(60)
Net Loss	(12,513,896)																									(12,513,896)
Balance at Dec. 31, 2023	$ 6,109,654							$ 4				$ 77,078						$ 153,192,228							$ (182,801)	$ (146,976,855)
Balance (in shares) at Dec. 31, 2023								427				7,705,640

CONSOLIDATED STATEMENTS OF ST_2

CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (Parenthetical) - USD ($)	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Closing costs	$ 381,877	$ 381,360
Series E Preferred Stock
Offering costs		136,401
Public Offering
Offering costs	132,684	$ 505,020
Public Offering | Series F Preferred Stock
Offering costs	214,477
Private Placement
Offering costs	$ 84,285

CONSOLIDATED STATEMENTS OF CASH

CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Operating Activities
Net Loss	$ (12,513,896)	$ (13,583,610)
Adjustments to Reconcile Net Loss to Net Cash Used in Operating Activities:
Closure of EyeGate Pharma S.A.S. Subsidiary	(53,882)	0
Depreciation and Amortization of Intangible Assets	51,798	41,609
Reduction of Right-of-Use Assets	10,626	92,419
Stock-Based Compensation	754,944	462,450
Impairment of In-Process R&D	1,904,314	0
Change in Fair Value of Contingent Consideration	1,992,399	582,605
Change in Fair Value of Warrant Liability	0	1,425,102
Deferred Taxes	90,319	(113,010)
Loss (Gain) on Disposal of Assets	28,379	(4,211)
Changes in Operating Assets and Liabilities:
Prepaid Expenses and Other Current Assets	885	275,161
Tax Receivables	(548,109)	(872,736)
Other Assets	(7,583)	(22,465)
Accounts Payable	(808,016)	782,463
Operating Lease Liabilities	584	(103,629)
Accrued Expenses	(459,713)	609,719
Net Cash Used in Operating Activities	(9,556,951)	(10,428,133)
Investing Activities:
Proceeds on Sale of Equipment	0	6,375
Net Cash Provided by Investing Activities	0	6,375
Financing Activities:
Exercise of Warrants	307,079	520,000
Proceeds from Private Placement, Net of Issuance Costs	115,715	0
Proceeds from Warrant Inducement, Net of Issuance Costs	0	2,738,831
Payments Made for Fractional Shares Related to the Reverse Stock Split	0	(15,629)
Payment of Contingent Consideration	(495,000)	0
Net Cash Provided by Financing Activities	5,966,066	8,620,921
Effect of Exchange Rate Changes on Cash	36,020	(85,037)
Net Decrease in Cash and Cash Equivalents	(3,554,865)	(1,885,874)
Cash and Cash Equivalents, Including Restricted Cash, Beginning of Year	6,013,816	7,899,690
Cash and Cash Equivalents, Including Restricted Cash, End of Year	2,458,951	6,013,816
Supplemental Disclosures of Noncash Operating and Financing Activities:
Creation of Right-of-Use Assets and Related Lease Liabilities	114,747	55,415
Grant of Restricted Stock Awards	10,345	300
Series E Preferred Stock
Supplemental Disclosures of Noncash Operating and Financing Activities:
Conversion of Preferred Stock into Common Stock	0	1,600
Series F Preferred Stock
Supplemental Disclosures of Noncash Operating and Financing Activities:
Conversion of Preferred Stock into Common Stock	31,706	0
Public Offering
Financing Activities:
Proceeds from issuance of common stock, net of offering costs	5,595,962	5,377,719
Equity Line Of Credit
Financing Activities:
Proceeds from issuance of common stock, net of offering costs	$ 442,310	$ 0

Business, Presentation and Rece

Business, Presentation and Recent Accounting Pronouncements	12 Months Ended
	Dec. 31, 2023
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Business, Presentation and Recent Accounting Pronouncements	Business, Presentation and Recent Accounting Pronouncements Business Overview Kiora is a clinical-stage specialty pharmaceutical company developing and commercializing therapies for the treatment of ophthalmic diseases. On November 5, 2021, Kiora Pharmaceuticals, Inc. (formerly known as EyeGate Pharmaceuticals, Inc.) (“Kiora” or the “Company”) filed with the Secretary of State of the State of Delaware, a Certificate of Ownership and Merger, merging its wholly-owned Delaware subsidiary, Kiora Pharmaceuticals, Inc., (incorporated in October 2021) into the Company and amending the Company’s certificate of incorporation to change its name to “Kiora Pharmaceuticals, Inc.” effective November 8, 2021. The Company's lead product is KIO-301 with an initial focus on patients with later stages of disease progression due to Retinitis Pigmentosa (any and all sub-forms). KIO-301 is a potential vision-restoring small molecule that acts as a “photoswitch” specifically designed to restore vision in patients with inherited and age-related degenerative retinal diseases. The molecule is specifically designed to restore the eyes’ ability to perceive and interpret light in visually impaired patients. It selectively enters viable downstream retinal ganglion cells (no longer receiving electrical input due to degenerated rods and cones) and is intended to turn them into light sensing cells, capable of signaling the brain as to the presence or absence of light. On March 17, 2022, the Company was granted Orphan Drug Designation from the U.S. FDA for the Active Pharmaceutical Ingredient (“API”) in KIO-301. The Company initiated a Phase 1b clinical trial in the third quarter of 2022 and completed the last patient dosing of the initial trial in September 2023 with topline results announced in November 2023. The Company is currently planning multiple Phase 2 clinical development trials in collaboration with our partner, TOI ("Théa Open Innovation"). KIO-301 (formerly known as B-203) was acquired through the Bayon Therapeutics, Inc. (“Bayon”) transaction which closed October 21, 2021. KIO-104 is a product that focuses on patients with Posterior Non-Infectious Uveitis. KIO-104 is a next-generation, non-steroidal, immune-modulatory and small-molecule inhibitor of Dihydroorotate Dehydrogenase (“DHODH”) with what the Company believes to be best-in-class picomolar potency and a validated immune modulating mechanism designed to overcome the off-target side effects and safety issues associated with commercially available DHODH inhibitors. Clinical proof-of-concept of the potential for the active pharmaceutical ingredient in KIO-104 has been demonstrated in multiple non-clinical and clinical studies. This includes a first-in-human, open-label, Phase 1 clinical trial, which investigated the use of KIO-104 for treating Posterior Non-Infectious Uveitis. Results, which were reported in October 2022, showed that a single intravitreal injection of KIO-104 decreased intraocular inflammation in a dose-dependent fashion, and improved visual acuity significantly during the duration of the study. Further, KIO-104 reduced macular edema (swelling) which if unchecked, can lead to permanent vision loss. The drug was well tolerated, with no serious side effects on intraocular tissues or other serious adverse events observed. The Company expects to initiate a Phase 2b clinical trial in the fourth quarter of 2024. KIO-104 (formerly known as PP-001 and containing the same Active Pharmaceutical Ingredient as KIO-101) was acquired through the acquisition of Panoptes Pharma Ges.m.b.H (“Panoptes”) in the fourth quarter of 2020. In addition, the Company has two anterior segment assets, KIO-101 for patients with Ocular Presentation of Rheumatoid Arthritis and KIO-201, for patients with Persistent Corneal Epithelial Defects ("PCED"). The Company is also evaluating KIO-201 in patients recovering from surgical wounds, such as those undergoing photorefractive keratectomy surgery for corneal wound repair after refractive surgery. KIO-101 is an eye drop formulation containing the same Active Pharmaceutical Ingredient as KIO-104. The Company reported data from a Phase 1b proof-of-concept ("POC") study evaluating KIO-101 in patients with ocular surface inflammation in Q4 2021. KIO-201 is a modified form of the natural polymer hyaluronic acid, designed to protect the ocular surface to permit re-epithelialization of the cornea and improve and maintain ocular surface integrity. KIO-201 has unique properties that help hydrate and protect the ocular surface. The Company released top-line data from a Phase 2 clinical trial in PCED in Q1 2023 and full data in Q2 2023. The Company is seeking a partner to complete the development and potential commercialization of this program. Since its inception, Kiora has devoted substantially all of its efforts to business planning, research and development, and raising capital. Going Concern The accompanying Consolidated Financial Statements have been prepared assuming that Kiora will continue as a going concern, which contemplates the realization of assets and satisfaction of liabilities in the normal course of business. At December 31, 2023, Kiora had unrestricted Cash and Cash Equivalents of $2.5 million, and an Accumulated Deficit of $147.0 million. Kiora has incurred losses and negative cash flows since inception, and future losses are anticipated. However, based on the cash on hand at December 31, 2023, plus approximately $32.4 million in gross cash receipts subsequent to year-end ( Note 13 ), the Company anticipates having sufficient cash to fund planned operations into 2026 and does not anticipate an immediate need within the next 24 months to raise additional capital to fund operations. Reverse Stock Split On September 23, 2022, the Company filed a Certificate of Amendment to its Restated Certificate of Incorporation (the “Amendment”) with the Secretary of State of the State of Delaware to effect a one-for-forty (1-for-40) reverse stock split of its outstanding common stock. The Amendment was approved by the Company’s stockholders at the Company’s 2022 Annual Meeting of Stockholders held on September 23, 2022, and by the Company’s board of directors. The Amendment became effective on September 27, 2022. The reverse stock split affected all shares of the Company’s common stock outstanding immediately prior to the effective time of the Amendment. As a result of the reverse stock split, proportionate adjustments were made to the per share exercise price and/or the number of shares issuable upon the exercise or vesting of all stock options, and restricted stock awards issued by the Company and outstanding immediately prior to the effective time of the Amendment, which resulted in a proportionate decrease in the number of shares of the Company’s common stock reserved for issuance upon exercise or vesting of such stock options, and restricted stock awards, and, in the case of stock options, a proportionate increase in the exercise price of all such stock options. In addition, the number of shares reserved for issuance under the Company’s equity compensation plans immediately prior to the effective time of the Amendment was reduced proportionately. The reverse stock split did not affect the number of shares or par value of common stock authorized for issuance under the Company’s Amended and Restated Certificate of Incorporation, which remained at 50,000,000 shares. No fractional shares were issued as a result of the reverse stock split. Stockholders of record who would otherwise have been entitled to receive a fractional share received a cash payment in lieu thereof. The reverse stock split affected all stockholders proportionately and did not affect any stockholder’s percentage ownership of the Company’s common stock (except to the extent that the reverse stock split results in any stockholder owning only a fractional share). As a result of the reverse stock split, the number of the Company’s outstanding shares of common stock as of September 27, 2022 decreased from 43,163,123 (pre-split) shares to 1,079,045 (post-split) shares. All share and per share amounts in the accompanying consolidated financial statements and related notes have been adjusted retroactively to reflect the reverse stock split as if it had occurred at the beginning of the earliest period presented. While the number of warrants outstanding did not change, the underlying shares did and are presented reflecting the split. The Company’s common stock began trading on The Nasdaq Capital Market on a split-adjusted basis when the market opened on September 27, 2022. Adoption of Accounting Standards In August 2020, the Financial Accounting Standards Board (FASB) issued Accounting Standards Update (ASU) 2020-06, Debt—Debt with Conversion and Other Options (Subtopic 470-20) and Derivatives and Hedging—Contracts in Entity's Own Equity (Subtopic 815-40): Accounting for Convertible Instruments and Contracts in an Entity's Own Equity. This guidance removes the liability and equity separation models for convertible instruments with a cash conversion feature or beneficial conversion feature. As a result, companies will more likely account for a convertible debt instrument wholly as debt, and for convertible preferred stock wholly as preferred stock (i.e., as a single unit of account). In addition, the guidance simplifies the settlement assessment that issuers perform to determine whether a contract in their own equity qualifies for equity classification. Finally, the guidance requires entities to use the if-converted method to calculate earnings per share for all convertible instruments. The Company adopted ASU 2020-06 on January 1, 2022. The adoption of ASU 2020-06 did not have a material effect for the Company. In May 2021, the FASB issued ASU 2021-04, Earnings Per Share (Topic 260), Debt—Modifications and Extinguishments (Subtopic 470-50), Compensation—Stock Compensation (Topic 718), and Derivatives and Hedging—Contracts in Entity’s Own Equity (Subtopic 815-40) to clarify an issuer’s accounting for certain modifications or exchanges of freestanding equity-classified written call options (for example, warrants) that remain equity classified after modification or exchange. Specifically, the ASU provides a principles-based framework to determine whether an issuer should recognize the modification or exchange as an adjustment to equity or an expense. The guidance is effective for annual reporting periods beginning after December 15, 2021, and interim periods within those fiscal years. The Company adopted ASU 2021-04 on January 1, 2022. The adoption of ASU 2021-04 did not have a material effect for the Company. In November 2021, the FASB issued ASU 2021-10, which requires business entities to disclose information about certain government assistance they receive. Such disclosure requirements include the nature of the transactions and the related accounting policy used, the line items on the balance sheet and income statement that are affected and the amounts applicable to each financial statement line item and significant terms and conditions of the transactions. ASU 2021-10 was effective for the Company January 1, 2022. The adoption of ASU 2021-10 did not have a material effect for the Company. In June 2016, the FASB issued ASU No. 2016-13, Financial Instruments - Credit Losses, to improve financial reporting by requiring timely recording of credit losses on loans and other financial instruments held by financial institutions and other organizations. The ASU requires the measurement of all expected credit losses for financial assets held at the reporting date based on historical experience, current conditions and reasonable and supportable forecasts. This guidance became effective for the Company on January 1, 2023. The adoption of ASU 2016-13 did not have a material effect for the Company. Accounting Pronouncements Pending Adoption In December 2023, the FASB issued ASU 2023-07, Segment Reporting (Topic 280) - Improvements to Reportable Segment Disclosures. The new standard requires a company to disclose incremental segment information on an annual and interim basis, including significant segment expenses and measures of profit or loss that are regularly provided to the chief operating decision maker (CODM). The standard is effective for us beginning in fiscal year 2024 and interim periods within fiscal year 2025, with early adoption permitted. We do not expect to early adopt the new standard. We are currently evaluating the impact of ASU 2023-07 on the consolidated financial statements and related disclosures and will adopt the new standard using a retrospective approach. In December 2023, the FASB also issued ASU 2023-09, Income Taxes (Topic 740) - Improvements to Income Tax Disclosures. The new standard requires a company to expand its existing income tax disclosures, specifically related to the rate reconciliation and income taxes paid. The standard is effective for us beginning in fiscal year 2025, with early adoption permitted. We do not expect to early adopt the new standard. The new standard is expected to be applied prospectively, but retrospective application is permitted. We are currently evaluating the impact of ASU 2023-09 on the consolidated financial statements and related disclosures.

Summary of Significant Accounti

Summary of Significant Accounting Policies	12 Months Ended
	Dec. 31, 2023
Accounting Policies [Abstract]
Summary of Significant Accounting Policies	Summary of Significant Accounting Policies Basis of Presentation and Principles of Consolidation The accompanying Consolidated Financial Statements include the accounts of the Company and its subsidiaries, Jade Therapeutics, Inc. (“Jade”), Kiora Pharmaceuticals, GmbH (“Kiora GmbH”) (formerly known as Panoptes Pharma Ges.m.b.H or “Panoptes”) (effective December 18, 2020 when the Company acquired all of the capital stock of Panoptes), Bayon Therapeutics, Inc. ("Bayon") (effective October 21, 2021 when the Company acquired all of the capital stock of Bayon), and Kiora Pharmaceuticals Pty Ltd (“Kiora Pty”) (formerly known as Bayon Therapeutics Pty Ltd), collectively referred to as “the Company”. All inter-company balances and transactions have been eliminated in consolidation. These Consolidated Financial Statements have been prepared in accordance with accounting principles generally accepted in the United States (“U.S. GAAP”). Use of Estimates The preparation of financial statements in conformity with U.S. GAAP requires management to make significant estimates and assumptions that affect the reported amounts of assets and liabilities, and disclosure of contingent assets and liabilities, at the date of the financial statements, and the reported amounts of expenses during the reporting periods. The Company makes significant estimates and assumptions in recording the accruals for the Company’s clinical trial and research activities, establishing the useful lives of intangible assets and property and equipment, conducting impairment reviews of in-process research and development (IPR&D), stock-based compensation, assumptions used to value warrants including warrant modifications and inducements, and contingent considerations payable. The Company bases its estimates on historical experience and various other assumptions that it believes to be reasonable under the circumstances. Although the Company monitors and regularly assesses these estimates, actual results could differ significantly from these estimates. The Company records changes in estimates in the period that it becomes aware of the change. Foreign Currency Translation Operations of Kiora GmbH are conducted in euros, which represent its functional currency. Operations of Kiora Pty are conducted in Australian dollars, which represent its functional currency. Balance sheet accounts of such subsidiaries were translated into U.S. dollars at the exchange rate in effect at the balance sheet date and income statement accounts were translated to the average rate of exchange prevailing during the period. Translation adjustments resulting from this process, are included in accumulated other comprehensive loss on the Consolidated Balance Sheets and a component of other comprehensive income (loss) on the Consolidated Statements of Operations and Comprehensive Loss. Cash and Cash Equivalents and Restricted Cash The Company considers all highly liquid investments purchased with a maturity of 90 days or less when acquired that are not restricted as to withdrawal, to be the equivalent of cash for the purpose of balance sheet and statement of cash flows presentation. The Company invests its cash in either U.S. government or treasury money market funds with maturities of 90 days or less. At December 31, 2023 and 2022, the Company has classified $4.3 thousand and $49.3 thousand as restricted cash, respectively. Property and Equipment Property and equipment is stated at cost less accumulated depreciation. Depreciation is provided for on a straight-line basis over the estimated useful life of 2 to 5 years for all assets. Maintenance and repair costs are expensed as incurred. The Company reviews its property and equipment whenever events or changes in circumstances indicate that the carrying value of certain assets might not be recoverable and recognizes an impairment loss when it is probable that the estimated cash flows are less than the carrying value of the asset. Impairment of Long-Lived Assets The Company evaluates potential impairment of long-lived assets and long-lived assets to be disposed of and considers whether long-lived assets held for use have been impaired whenever events or changes in circumstances indicate that the related carrying amount may not be recoverable, or that the period of their recovery may have changed. Management makes significant estimates and assumptions regarding future sales, cost trends, productivity and market maturity in order to test for impairment. Management reports those long-lived assets to be disposed of and assets held for sale at the lower of carrying amount or fair value less cost to sell. Based on current facts, estimates and assumptions, management believes that no assets are impaired at December 31, 2023. There is no assurance that management’s estimates and assumptions will not change in future periods. Research and Development Expenses The Company expenses research and development (“R&D”) expenditures as incurred. R&D expenses are comprised of costs incurred in performing R&D activities, including salaries, benefits, facilities, research-related overhead, sponsored research costs, contracted services, license fees, expenses related to generating, filing, and maintaining intellectual property and other external costs. Because the Company believes that, under its current process for developing its products, the viability of the products is essentially concurrent with the establishment of technological feasibility, no costs have been capitalized to date. In-Process Research and Development The Company records in-process R&D projects acquired in asset acquisitions that have not reached technological feasibility and which have no alternative future use. For in-process R&D projects acquired in business combinations, the Company capitalizes the in-process R&D project as an indefinite-lived intangible asset and evaluates this asset annually for impairment until the R&D process has been completed. Once the R&D process is complete, the Company amortizes the R&D asset over its remaining useful life. The Company performed an annual evaluation of its indefinite-lived intangible assets for impairment as of August 31, 2023 and 2022 with a quantitative analysis. In connection with its 2023 analysis, the Company recognized an impairment of $1.9 million. As of December 31, 2023 and 2022 the Company also performed a qualitative update analysis for impairment and based on this analysis, the fair value of these products was greater than their carrying value. The Company considered the progress and development timelines for its programs and noted no qualitative factors that would indicate potential impairment of its indefinite-lived intangible assets. At December 31, 2023 and 2022, there is $8.7 million and $10.6 million, respectively, of in-process R&D as part of intangible assets and in-process R&D, net on the Consolidated Balance Sheets. Accrued Clinical Expenses As part of the Company’s process of preparing the Consolidated Financial Statements, the Company is required to estimate its accrued expenses. This process includes reviewing open contracts and purchase orders, communicating with its applicable personnel to identify services that have been performed on its behalf and estimating the level of service performed and the associated costs incurred for the service when the Company has not yet been invoiced or otherwise notified of actual costs. The majority of the Company’s service providers invoice monthly in arrears for services performed. The Company makes estimates of its accrued expenses as of each balance sheet date in the financial statements based on facts and circumstances known at the time. The Company periodically confirms the accuracy of these estimates with the service providers and makes adjustments if necessary. Business Segment and Geographical Information The Company identifies operating segments as components of the enterprise for which separate discrete financial information is available for evaluation by the chief operating decision maker, or decision-making group, in making decisions on how to allocate resources and assess performance. The Company views its operations and manages its business as fully integrated and operating in one business segment (research and development), and the Company operates in three geographic areas. Income Taxes The Company will record a deferred income tax asset and liability for the expected future income tax consequences of events that have been recognized in the Company’s consolidated financial statements and income tax returns. The Company will record a deferred income tax asset and liability based on differences between the financial statement carrying, or “book”, amounts of assets and liabilities, and the tax bases of the assets and liabilities using the enacted income tax regulations in effect in the years in which the differences are expected to reverse. A valuation allowance against deferred income tax asset will be recorded if, based on the weight of available evidence, it is more likely than not that some or all of the deferred income tax assets will not be realized. As of December 31, 2023 and 2022, all of the Company’s net deferred income tax assets were subject to a full valuation allowance. As of December 31, 2023 and 2022, the Company has a net deferred tax liability of $0.8 million and $0.7 million, respectively. The Company recognizes the impact of an uncertain income tax position in the financial statements if it believes that the position is more likely than not to be sustained by the relevant taxing authority. As of December 31, 2023, the Company had no unrecognized uncertain income tax positions. Warrant Liability The Company classifies warrants to purchase shares of its common stock as a liability on its Consolidated Balance Sheets when the warrant is a free-standing financial instrument that may require the Company to transfer cash consideration upon exercise and that cash transfer event would be out of the Company’s control. Such a “warrant liability” is initially recorded at fair value on date of grant using the Black-Scholes model, and it is subsequently re-measured to fair value at each subsequent balance sheet date. Changes in the fair value of the warrant are recognized as a component of other income (expense), net in the Consolidated Statements of Operations and Comprehensive Loss. The Company will adjust the liability for changes in fair value until the earlier of the exercise or expiration of the warrant or meeting the requirements to be reclassified to equity. For warrants that do not meet the criteria of a liability warrant and are classified on the Company’s Consolidated Balance Sheets as equity instruments, the Company uses the Black-Scholes model to measure the value of the warrants at issuance and then applies the relative fair-value of the equity transaction between common stock, preferred stock and warrants. Common stock and equity-classified warrants each are considered permanent equity. Refunds for Research and Development Kiora, through its Kiora GmbH and Kiora Pty Ltd. subsidiaries, is eligible to receive certain refundable tax incentives associated with its research and development expenses in Austria and Australia. These refunds are realized in the form of a cash payment when received, following the incurred research and development expenses. The Company records the refundable payment as a tax receivable and a reduction in expense in the period in which the research and development expenses are incurred. As of December 31, 2023 and 2022, the Company has a research and development tax receivable of $1.9 million and $1.3 million, respectively. Concentration of Credit Risk and Off-Balance-Sheet Risk Financial instruments that potentially subject the Company to significant concentrations of credit risk consist principally of cash and cash equivalents. The Company invests cash in accredited financial institutions and cash equivalents in widely held money market funds. Consequently, such funds are subject to minimal credit risk. The Company has no significant off-balance-sheet risk such as foreign exchange contracts, option contracts, or other foreign hedging arrangements. Comprehensive Loss Comprehensive loss is defined as the change in stockholders’ equity during a period from transactions and other events and circumstances from non-owner sources. The foreign currency translation adjustments are the Company’s only component of other comprehensive loss. Stock-Based Compensation Stock-based compensation represents the cost related to stock-based awards granted to employees and others. The Company measures stock-based compensation cost to employees and non-employees at grant date, based on the estimated fair value of the award. Compensation cost for employee awards is recognized as expense on a straight-line basis over the employee requisite service period. The Company estimates the fair value of stock options using the Black-Scholes valuation model. The Company recorded compensation expense for non-employee awards with graded vesting using the accelerated expense attribution method. The Company’s policy is to record forfeitures as they occur. Net Loss per Share – Basic and Diluted Basic and diluted net loss per share is computed by dividing net loss available to common shareholders by the weighted-average number of common shares outstanding for the period, which, for basic net loss per share, does not include the weighted-average unvested restricted common stock that has been issued but is subject to forfeiture of 229,373 shares for year ended December 31, 2023 and 30,000 shares for the year ended December 31, 2022. Dilutive common equivalent shares consist of stock options, warrants, and preferred stock and are calculated using the treasury stock method, which assumes the repurchase of common shares at the average market price during the period. Under the treasury stock method, options and warrants will have a dilutive effect when the average price of common stock during the period exceeds the exercise price of options or warrants. Common equivalent shares do not qualify as participating securities. In periods where the Company records a net loss, including the years ended December 31, 2023 and 2022, unvested restricted common stock and potential common stock equivalents are not included in the calculation of diluted net loss per share as their effect would be anti-dilutive. All shares of Common Stock that may potentially be issued in the future are as follows: Year Ended December 31, 2023 2022 Common Stock Warrants 13,064,299 1,597,606 Employee Stock Options 812,945 84,751 Restricted Stock 229,373 30,000 Preferred Stock 381,832 52 Total Shares of Common Stock Issuable 14,488,449 1,712,409 Related-Party Transactions During the year ended December 31, 2023, the Company entered into certain related-party transactions, making payments for services to one vendor, three employees and fifteen consultants, all of whom also are stockholders of the Company. These transactions generally involve a stockholder or option holder of the Company to whom the Company also makes payments during the year, typically as a consultant or a service provider. The Company made payments of approximately $0.1 million for services to the related party vendor Ora, Inc. where one of the Company’s directors is an executive and who the Company has engaged for KIO-301 clinical study services. The Company made payments of $0.5 million to consultants for advisory services. The Company employs a family member of our Chief Development Officer and incurred approximately $0.1 million in employment related costs. Additionally, in December 2023, in connection with the acquisition of Bayon Therapeutics, Inc., the Company issued $0.5 million in milestone payments to former shareholders of Bayon Therapeutics, Inc., including our President and CEO and Chief Development Officer. Fair Value Measurements Fair value accounting is applied to all financial assets and liabilities that are recognized or disclosed at fair value in the consolidated financial statements on a recurring basis (at least annually). As of December 31, 2023 and 2022, the carrying amounts of cash equivalents, tax receivables, accounts payable, and accrued liabilities approximated their fair values due to their relatively short maturities. Assets and liabilities recorded at fair value on a recurring basis on the consolidated balance sheets are categorized based upon the level of judgment associated with the inputs used to measure their fair values. Fair value is defined as the exchange price that would be received for an asset or an exit price that would be paid to transfer a liability in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. Valuation techniques used to measure fair value must maximize the use of observable inputs and minimize the use of unobservable inputs. The authoritative guidance on fair value measurements establishes a three-tier fair value hierarchy for disclosure of fair value measurements as follows: Level 1 - Observable inputs such as unadjusted, quoted prices in active markets for identical assets or liabilities at the measurement date. Level 2 - Inputs (other than quoted prices in active markets included in Level 1) are either directly or indirectly observable for the asset or liability. These include quoted prices for similar assets or liabilities in active markets and quoted prices for identical or similar assets or liabilities in markets that are not active. Level 3 - Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities. There were no assets or liabilities valued at fair value using Level 1 or 2 inputs. The following table provides information for assets and liabilities measured at fair value on a recurring basis using Level 3 inputs: December 31, 2023 December 31, 2022 Contingent Consideration: Current — 322,385 Noncurrent 5,128,959 3,309,175 Total Contingent Consideration $ 5,128,959 $ 3,631,560 The Company's in-process R&D is measured at fair value on a nonrecurring basis. As of December 31, 2023 and 2022, the in-process R&D balance was $8.7 million and $10.6 million, respectively.

Fair Value

Fair Value	12 Months Ended
	Dec. 31, 2023
Fair Value Disclosures [Abstract]
Fair Value	Fair Value Contingent Consideration Each period the Company revalues its contingent consideration obligations associated with business acquisitions to their fair value. The estimate of the fair value of contingent consideration is determined by applying probability of success, discount rate, and updated timing of the payment. The outstanding payments relate to obligation from acquisitions made by the Company. Below is the list of obligations for each relevant transaction as of December 31, 2023 as follows: Acquisition Milestone Achievement Condition Contingent Consideration Payable Bayon Successful completion of Phase 2 $ 1.0 million Successful completion of Phase 3 $ 4.0 million FDA approval $ 1.7 million Panoptes Beginning of Phase 3 $ 4.8 million FDA approval $ 4.8 million Jade FDA approval $ 2.2 million Changes in the fair value of contingent consideration are included within “Operating Expenses” in the Company's Consolidated Statements of Operations and Comprehensive Loss. Below are the status of each transaction's contingent consideration: Bayon : The Bayon acquisition closed on October 21, 2021. As of December 31, 2022, the Company recorded contingent consideration of $1.1 million. During the year ended December 31, 2023, the Company recorded an increase in estimated fair value of $1.7 million, partially offset by a milestone payment of $0.5 million. The estimated fair value of contingent consideration as of December 31, 2023 was $2.4 million. Panoptes : The Panoptes transaction closed December 18, 2020. As of December 31, 2022, the Company recorded contingent consideration of $1.7 million. During the year ended December 31, 2023, the Company recorded an increase in estimated fair value of $0.2 million. The estimated fair value of contingent consideration as of December 31, 2023 was $2.0 million. Jade : As of December 31, 2022, the Company recorded contingent consideration of $0.7 million. During the year ended December 31, 2023, the Company recorded an increase in estimated fair value of $37.4 thousand. The estimated fair value of contingent consideration as of December 31, 2023 was $0.8 million. At December 31, 2023 and 2022, the Company had no other assets or liabilities that are subject to fair value methodology and estimation in accordance with U.S. GAAP. The Company initially values contingent consideration related to business combinations using a probability-weighted calculation of potential payment scenarios discounted at rates reflective of the risks associated with the expected future cash flows for certain milestones. Key assumptions used to estimate the fair value of contingent consideration include projected financial information, market data and the probability and timing of achieving the specific targets as discussed above. Fair Value of Financial Instruments. After the initial valuation, the Company generally uses its best estimate to measure contingent consideration at each subsequent reporting period using the following unobservable Level 3 inputs: Valuation Technique Unobservable Inputs December 31, 2023 December 31, 2022 Discounted cash flow Payment discount rate 13.1% 14.7% Bayon Payment period 2025 - 2027 2023 - 2028 Panoptes Payment period 2026 - 2028 2024 - 2028 Jade Payment period 2027 2026 Bayon Probability of Success for milestone 42% - 71% 17% - 67% Panoptes Probability of Success for milestone 30% - 33% 17% - 36% Jade Probability of Success for milestone 56% 56% Significant changes in these assumptions could result in a significantly higher or lower fair value. The contingent consideration reported in the above table is adjusted quarterly based upon the passage of time or the anticipated success or failure of achieving certain milestones. The changes in contingent consideration of $1.5 million as of December 31, 2023, was primarily driven by higher estimated probabilities of success and a decreased discount factor and was recorded as a change in fair value of contingent consideration of $2 million within the Consolidated Statements of Operations and Comprehensive Loss, which was partially offset by a milestone payment of $0.5 million. In-process R&D The Company records in-process R&D projects acquired in asset acquisitions that have not reached technological feasibility and which have no alternative future use. For in-process R&D projects acquired in business combinations, the Company capitalizes the in-process R&D project as an indefinite-lived intangible asset and evaluates this asset annually for impairment until the R&D process has been completed. Once the R&D process is complete, the Company amortizes the R&D asset over its remaining useful life. ASC 350 allows an entity to first assess qualitative factors to determine whether events and circumstances indicate that it is more likely than not (that is, a likelihood of more than 50 percent) that an indefinite-lived intangible asset is impaired. If it is more likely than not that the asset is impaired, the entity must calculate the fair value of the asset and record an impairment charge if the carrying amount exceeds fair value. If an entity concludes that it is not more likely than not that the asset is impaired, no further action is required. An indefinite-lived intangible asset should be tested for impairment if events or changes in circumstances indicate that it is more likely than not that the asset is impaired. If such events or changes have occurred, a quantitative assessment is required. If an entity bypasses the qualitative assessment or determines from its qualitative assessment that an indefinite-lived intangible asset is more likely than not impaired, a quantitative impairment test should be performed. The quantitative impairment test compares the fair value of an indefinite-lived intangible asset with the asset’s carrying amount. If the fair value of the indefinite-lived intangible asset is less than the carrying amount, an impairment loss should be recognized in an amount equal to the difference in accordance with ASC 350-30-35-19. The Company values in-process R&D related to asset acquisitions using the Income Approach which measures the value of an asset by the present value of its future economic benefits. These benefits can include earnings, cost savings, tax deductions, or proceeds from its disposition. Value indications are developed by discounting expected cash flows at a rate of return that incorporates the risk-free rate for the use of funds, the expected rate of inflation, and risks associated with the particular investment. The selected discount rate is the Company’s weighted average cost of capital (“WACC”), which provides an expected rate of return based on the Company’s capital structure, the required yield on the Company’s equity, and the required yield on the interest-bearing debt of which there is currently none. Management completed, with the assistance of a third party valuation firm, a quantitative assessment of in-process R&D as of August 31, 2023, the Company's annual impairment test date, which includes the following unobservable Level 3 inputs: Valuation Technique Unobservable Inputs Input Discount Rate KIO-101 Relief from Royalty Method Probability of success for next development phase 17% 30% KIO-104 Multi-Period Excess Earnings Method Probability of success for next development phase 17% to 36% 25% KIO-201 Relief from Royalty Method Probability of success for next development phase 17% to 46% 30% KIO-301 Multi-Period Excess Earnings Method Probability of success for next development phase 17% to 67% 25%

Property and Equipment

Property and Equipment	12 Months Ended
	Dec. 31, 2023
Property, Plant and Equipment [Abstract]
Property and Equipment	Property and Equipment Property and equipment at December 31, 2023 and 2022 consists of the following: Estimated Useful 2023 2022 Laboratory Equipment 3 $ 11,832 $ 88,399 Office Equipment 3 2,521 3,409 Office Furniture 5 — 58,119 Leasehold Improvements 2 — 22,569 Total Property and Equipment, Gross 14,353 172,496 Less Accumulated Depreciation 6,289 117,319 Total Property and Equipment, Net $ 8,065 $ 55,177 Depreciation expense was $30 thousand and $17 thousand for the years ended December 31, 2023 and 2022, respectively.

Accrued Expenses

Accrued Expenses	12 Months Ended
	Dec. 31, 2023
Accrued Liabilities [Abstract]
Accrued Expenses	Accrued Expenses Accrued expenses consist of the following: December 31, 2023 2022 Payroll and Benefits $ 875,254 $ 1,312,443 Professional Fees 43,387 282,721 Clinical Trials 397,465 57,020 Other 64,560 183,750 Total Accrued Expenses $ 1,380,666 $ 1,835,934

Intangible Assets and In-Proces

Intangible Assets and In-Process R&D	12 Months Ended
	Dec. 31, 2023
Goodwill and Intangible Assets Disclosure [Abstract]
Intangible Assets and In-Process R&D	Intangible Assets and In-Process R&D Intangible assets at December 31, 2023 and 2022 consist of the rights to trade-secrets and know-how related to the manufacturing of KIO-201. During the third quarter of 2018, the Company entered into an intellectual property license agreement with SentrX Animal Care, Inc. (“SentrX”) with respect to certain rights relating to the manufacturing of KIO-201. The intangible assets were recorded at $0.3 million, representing the upfront payment paid to SentrX. Additionally, SentrX was eligible to receive milestone payments totaling up to $4.8 million, upon and subject to the achievement of certain specified development and commercial milestones. These future milestone payments to SentrX would have increased the carrying value of the intangible assets, however, on June 7, 2023, the Company entered into an amendment agreement (the "SentrX First Amendment") whereby SentrX removed the Company's obligation to make any further payments, milestone or otherwise. The term of the agreement is until the product is no longer in the commercial marketplace. In addition, on June 7, 2023, we entered into a new exclusive license agreement (the "New SentrX Agreement") with SentrX, whereby we out-licensed certain KIO-201 patents for use in animal health and veterinary medicine. Under the New SentrX Agreement, SentrX is obligated to pay the Company a flat low single-digit royalty on net sales and is effective until the last licensed patent terminates. The Company’s intangible assets are amortized on a straight-line basis over the estimated useful lives. Additionally, in-process R&D as of December 31, 2023 and 2022 consists of projects acquired from the acquisitions of Jade, Bayon and Panoptes that have not reached technological feasibility and which have no alternative future use. Once the R&D process is complete, the Company will amortize the R&D asset over its remaining useful life. The Company periodically evaluates these assets for impairment. Intangible assets and in-process R&D at December 31, 2023 and 2022 consists of the following: Estimated Useful 2023 2022 Trade Secrets 10 $ 250,000 $ 250,000 Less: Accumulated Amortization (131,250) (106,250) Intangible Assets, Net 118,750 143,750 In-Process R&D 8,695,100 10,599,414 Total Intangible Assets and In-Process R&D, Net $ 8,813,850 $ 10,743,164 Amortization expense on intangible assets was $25 thousand for each of the years ended December 31, 2023 and 2022. Expected future amortization expense is as follows for the years ending December 31,: Intangible Assets 2024 $ 25,000 2025 25,000 2026 25,000 2027 25,000 2028 18,750 Total $ 118,750

Capital Stock

Capital Stock	12 Months Ended
	Dec. 31, 2023
Equity [Abstract]
Capital Stock	Capital Stock On June 18, 2022, in connection with the Company’s acquisition of Panoptes in December 2020 (“Panoptes Acquisition”), the Company issued an aggregate of 10,087 shares of common stock to former shareholders of Panoptes, which had been held back for a period of eighteen months following the closing of the Panoptes acquisition to satisfy post-closing adjustment and indemnification obligations pursuant to the terms of the Share Purchase Agreement between the Company and the former shareholders of Panoptes. On July 22, 2022, the Company entered into an underwriting agreement to issue and sell stock and warrants in a public offering (the “Public Offering”). On July 25, 2022, the underwriter fully exercised the over-allotment option granted by the Company to purchase stock and warrants (the “Option”). On July 26, 2022, the Public Offering closed, and the Company issued and sold (i) 592,392 shares of common stock (the “Common Shares”) (including 98,138 Common Shares sold pursuant to the exercise of the Option), (ii) 1,280 shares of Series E Convertible Preferred Stock (the “Preferred Shares”) convertible into up to 160,000 shares of common stock, (iii) 30,095,697 Class A Warrants (including 3,925,525 Class A Warrants sold pursuant to the exercise of the Option), and (iv) Each Warrant is exercisable at a price per share of common stock of $8.00. The Class A Warrants expired on September 23, 2023 and the Class B Warrants will expire on September 23, 2027. The exercise prices of the Warrants are subject to appropriate adjustment in the event of recapitalization events, stock dividends, stock splits, stock combinations, reclassifications, reorganizations or similar events affecting the Company’s common stock. During August 2022, all holders of the Series E Preferred Shares issued in the Public Offering, elected to convert their Series E Preferred Shares into 160,000 shares of Common Stock. On November 17, 2022, the Company entered into warrant exercise inducement offer letters with some of the Class A Warrant holders who agreed to exercise for cash all of their Class A Warrants to purchase 654,609 shares of common stock originally issued in the Public Offering in exchange for the Company's agreement to issue new warrants (the “Inducement Warrants”) on substantially the same terms as the Class A Warrants to purchase up to 654,609 shares of common stock. Each Inducement Warrant is exercisable at a price per share of common stock of $5.97. Each Inducement Warrant will initially be exercisable six months following its date of issuance, and will expire on the eighteen month anniversary of their initial exercise date. The Company received aggregate gross proceeds of approximately $3.1 million from the exercise of the Class A Warrants by the selling stockholders and the sale of the Inducement Warrants. The Company paid its placement agent in connection with the inducement transactions a fee equal to 8% of gross proceeds from the exercise of the Class A Warrants. On February 10, 2023, a holder exercised Class C warrants Exercised resulting in the issuance of 50,000 shares of common stock and proceeds of $0.3 million. On February 3, 2023, the Company completed a private placement with Lincoln Park Capital, LLC ("Lincoln Park") for 52,798 shares of common stock and warrants to purchase up to 105,596 shares of common stock. The total net proceeds from the private placement were approximately $0.1 million. The warrants have an exercise price of $3.538 per share, subject to adjustments as provided under the terms of the warrants, and became exercisable on the six-month anniversary of the closing date. The warrants are exercisable for five years from the issuance date. On February 3, 2023, the Company also entered into a purchase agreement with Lincoln Park, pursuant to which Lincoln Park agreed to purchase from the Company up to an aggregate of $10,000,000 of common stock (subject to certain limitations), from time to time and at the Company's sole discretion over the term of the purchase agreement. On February 22, 2023, the Company completed its first issuance under this agreement for a total of 20,000 shares sold to Lincoln Park for proceeds of $0.1 million. In April 2023, the Company completed additional issuances for a total of 105,000 shares sold to Lincoln Park for proceeds of $0.3 million. On March 30, 2023, the Company entered into an underwriting agreement to issue and sell stock and warrants in a public offering. On June 6, 2023, the public offering closed, and the Company issued and sold (i) 2,197,628 shares of common stock (including 750,000 shares of common stock sold pursuant to the exercise of the over-allotment option), (ii) 3,908 shares of Series F Convertible Preferred Stock convertible into up to 3,552,372 shares of common stock, (iii) 5,750,000 Class C Warrants (including 750,000 Class C Warrants sold pursuant to the exercise of the over-allotment option), and (iv) 5,750,000 Class D Warrants (including 750,000 Class D Warrants sold pursuant to the exercise of the over-allotment option). The public offering price of $1.10 per share of common stock, Class C Warrant and Class D Warrant, and $999.90 per share of Series F Convertible Preferred Stock, 909 Class C Warrants and 909 Class D Warrants, resulted in net proceeds to the Company of approximately $5.6 million net of underwriting discount and commissions of $0.5 million and other expenses of $0.2 million. On June 6, 2023, the underwriter fully exercised the over-allotment option granted by the Company to purchase stock and warrants. Each Warrant is exercisable at a price per share of common stock of $1.10. The Class C Warrants will expire on June 6, 2028 and the Class D Warrants will expire on June 6, 2024. The exercise prices of the warrants are subject to appropriate adjustment in the event of recapitalization events, stock dividends, stock splits, stock combinations, reclassifications, reorganizations or similar events affecting the Company’s common stock. In addition, on August 5, 2023, the 60th calendar day immediately following the initial exercise day, the exercise price of the warrants was reduced to $0.5231 per share pursuant to the reset provision which stated that the warrants would be reduced to the lesser of (i) the exercise price then in effect and (ii) 90% of the average of the volume weighted average price of the Company's common stock for the five (5) trading day period immediately prior to the reset date. In accordance with ASU 2021-04, the warrant reset of the exercise price was evaluated as a modification of equity-classified written call options. Modifications or exchanges that are not related to debt or equity financings, compensation for goods or services, or other exchange transactions within the scope of other guidance should be recognized as a dividend consistent with ASC 815-40-35-17(d). The dividend amount is measured as the excess, if any, of the fair value of the modified or exchanged instrument over the fair value of that instrument immediately before it is modified or exchanged in accordance with ASC 815-40-35-16. The Company considered the guidance in paragraphs 815-40-35-14 through 35-17 and determined that the circumstances of the warrant modification indicate that the modification is executed separate from a new equity offering, debt origination or debt modification. As such, on August 7, 2023, the date on which the modification became effective, the incremental change in the fair value of the 11,500,000 outstanding warrants was recognized as a deemed dividend totaling $0.5 million that increases net loss attributable to common stockholders in accordance with paragraph 815-40-35-17(d) and ASC 260-10-45-15. During June 2023, 2,958 shares of Series F Convertible Preferred Stock were converted into 2,688,822 shares of common stock. During July and August 2023, 530 shares of Series F Convertible Preferred Stock were converted into 481,770 shares of common stock. In addition to the 50,000 shares of Class C warrants exercised in February 2023, during November 2023, 8,200 shares of Class C warrants and 8,200 shares of Class D warrants were exercised for $8.6 thousand.

Warrants

Warrants	12 Months Ended
	Dec. 31, 2023
Warrants
Warrants	Warrants At December 31, 2023 and 2022, the following warrants were outstanding: Number of Weighted Weighted Outstanding at December 31, 2021 168,932 $ 199.65 3.42 Issued 2,159,395 7.38 2.55 Exercised (719,609) 5.06 Expired (11,112) 900.00 Outstanding at December 31, 2022 1,597,606 $ 21.22 3.07 Issued 11,605,596 0.55 3.02 Exercised (66,400) 5.97 Expired (72,503) 108.80 Outstanding at December 31, 2023 13,064,299 $ 2.40 2.43 All of the warrant agreements provide for a cashless exercise in the event a registration statement covering the issuance of the shares of common stock underlying the warrants is not effective, whereby the number of shares to be issued upon exercise of such warrants will be reduced based on the exercise price and the market value of the shares at the time of exercise. The outstanding warrants expire from 2024 through 2028.

Equity Incentive Plan

Equity Incentive Plan	12 Months Ended
	Dec. 31, 2023
Equity Incentive Plan
Equity Incentive Plan	Equity Incentive Plan In 2005, the Company approved the 2005 Equity Incentive Plan (the “2005 Plan”). The 2005 Plan provides for the granting of options, restricted stock or other stock-based awards to employees, officers, directors, consultants, and advisors. During 2010, the maximum number of shares of Common Stock that may be issued pursuant to the 2005 Plan was increased to 59,414 shares. The Board of Directors (the “Board”) is responsible for administration of the 2005 Plan. The Company’s Board determines the term of each option, the option exercise price, the number of shares for which each option is granted and the rate at which each option is exercisable. Incentive stock options may be granted to any officer or employee at an exercise price per share of not less than the fair value per common share on the date of the grant (not less than 110% of fair value in the case of holders of more than 10% of the Company’s voting stock) and with a term not to exceed ten years from the date of the grant (five years for incentive stock options granted to holders of more than 10% of the Company’s voting stock). Nonqualified stock options may be granted to any officer, employee, consultant, or director at an exercise price per share of not less than the par value per share. Following adoption of the 2014 Equity Incentive Plan (the “2014 Plan”), no further grants were made under the 2005 Plan. General terms of the 2014 Plan remain the same as that of the 2005 plan. The Company’s Board adopted the 2014 Plan and the Employee Stock Purchase Plan (the “ESPP”), and the Company’s Stockholders approved the 2014 Plan and the ESPP Plan in February 2015. As of December 31, 2023, the maximum number of shares of Common Stock that may be issued pursuant to the 2014 Plan and the ESPP was 1,298,848 and 284 shares, respectively. In January 2023, the number of shares of common stock issuable under the 2014 Plan automatically increased by 76,632 shares pursuant to the terms of the 2014 Plan. Additionally, in September 2023, the number of shares of common stock issuable under the 2014 Plan was increased by 1,000,000 shares, as approved by the Company’s Stockholders. These additional shares are included in the total of 1,298,848 shares issuable under the 2014 Plan. As of December 31, 2023, there were 183,604 shares of Common Stock available for grant under the 2014 Plan and 191 shares available under the Company’s ESPP. The following is a summary of stock option activity for the years ended December 31, 2023 and 2022: Number of Weighted Average Weighted Average Outstanding at December 31, 2021 12,954 $ 426.25 5.56 Granted 78,641 8.49 Expired (14) 842.57 Forfeited (6,830) 446.34 Outstanding at December 31, 2022 84,751 $ 36.92 9.59 Exercisable at December 31, 2022 4,939 $ 442.52 7.27 Vested and Expected to Vest at December 31, 2022 84,751 $ 36.92 9.59 Granted 764,400 1.11 Expired (927) 373.32 Forfeited (35,279) 5.08 Outstanding at December 31, 2023 812,945 $ 4.26 9.56 Exercisable at December 31, 2023 173,394 $ 13.79 9.46 Vested and Expected to Vest at December 31, 2023 812,945 $ 4.26 9.56 During the years ended December 31, 2023 and 2022, the Board approved the grant of options to purchase 764,400 and 78,641 shares of its Common Stock, respectively. All option grants were pursuant to the 2014 Plan. The Company grants time-based stock options which generally vest one-third of the underlying shares on the one-year anniversary of the grant date and the remainder ratably over a 24-month period. The Company has also issued grants with a four-year vesting term, of which one-fourth of the underlying shares vested immediately, one-fourth on the one-year anniversary of the grant date and the remainder vest ratably over a 24-month period. The fair value of time-based stock options is determined using the Black-Scholes Option Pricing Model, with such value recognized as expense over the service period, which is typically three years, net of actual forfeitures. For the years ended December 31, 2023 and 2022, the fair value of each option grant has been estimated on the date of grant using the Black-Scholes Option Pricing Model with the following weighted-average assumptions: 2023 2022 Risk-Free Interest Rate 3.95% - 4.61% 2.42% Expected Life 5.0 - 5.6 years 5.0 years Expected Average Volatility 141.0% - 145.2% 140% Expected Dividend Yield 0% 0% Using the Black-Scholes Option Pricing Model, the estimated weighted average fair value of an option to purchase one share of common stock granted during the years ended December 31, 2023 and 2022 was $1.11 and $27.08 respectively. The expected term of the options granted is calculated in accordance with the simplified method, whereby for service-based awards the expected life is calculated as a midpoint between the vest and expiry period. The Company uses the simplified method as there is not a sufficient history of share option exercises. Expected volatility is based on the historical volatility of the Company’s common stock. The risk-free interest rate is determined based upon a constant U.S. Treasury security rate with a contractual life that approximates the expected term of the option. The following is a summary of restricted stock activity for the years ended December 31, 2023 and 2022: Number of Weighted-Average Weighted-Average Non-vested Outstanding at December 31, 2021 375 $ 261.47 1.09 Awarded 30,000 6.78 Released (248) 261.45 Forfeited (127) 261.51 Non-vested Outstanding at December 31, 2022 30,000 $ 6.78 2.79 Awarded 270,050 1.06 Released (67,377) 1.49 Forfeited (3,300) 3.83 Non-vested Outstanding at December 31, 2023 229,373 $ 1.64 2.57 During the years ended December 31, 2023 and 2022, 3,300 and 127 shares of restricted stock, which had not vested, were forfeited and returned to the Company, respectively. During the years ended December 31, 2023 and 2022, the Board approved the grant of 270,050 and 30,000 restricted shares of Common Stock, respectively. All grants of restricted shares were pursuant to the 2014 Plan. These vest with respect to one-third of the underlying shares on the one-year anniversary of the grant date and the remainder ratably over a 24-month period. The total stock-based compensation expense for employees and non-employees is included in the accompanying Consolidated Statements of Operations and as follows: Year Ended December 31, 2023 2022 General and Administrative $ 345,488 $ 343,475 Research and Development 409,456 118,975 Total Stock-Based Compensation Expense $ 754,944 $ 462,450 The fair value of options granted for the years ended December 31, 2023 and 2022 was approximately $0.8 million and $0.6 million, respectively. As of December 31, 2023 and 2022, there was approximately $0.8 million and $0.7 million of total unrecognized compensation expense related to unvested stock-based compensation arrangements granted, which cost is expected to be recognized over a weighted average period of 2.1 and 2.4 years, respectively. The stock options outstanding and exercisable as of December 31, 2023 and 2022 had an aggregate intrinsic value of $0. The aggregate intrinsic value is calculated as the difference between the exercise price of the underlying options and the market price of the Company’s common stock for options that had exercise prices lower than $0.5220 and $3.43, the closing price of the Company’s stock on December 31, 2023 and 2022, respectively. Unamortized compensation expense related to the restricted stock awards amounted to $0.3 million and $0.2 million as of December 31, 2023 and 2022, respectively, and is expected to be recognized over a weighted average period of approximately 2.3 and 2.8 years, respectively.

Income Taxes

Income Taxes	12 Months Ended
	Dec. 31, 2023
Income Tax Disclosure [Abstract]
Income Taxes	Income Taxes The components of loss before income taxes are as follows: Year Ended December 31, 2023 2022 Domestic $ (9,384,178) $ (10,563,302) Foreign (3,039,399) (3,133,318) Total Loss Before Income Taxes $ (12,423,577) $ (13,696,620) The components of income tax expense (benefit) are as follows: Year Ended December 31, 2023 2022 Deferred Taxes: Federal $ (280,954) $ 4,954 State 371,273 (117,964) Total Deferred Taxes $ 90,319 $ (113,010) Income Tax Expense (Benefit) $ 90,319 $ (113,010) The difference between the effective rate reflected in the provision for income taxes and the amounts determined by applying the applicable statutory U.S. tax rate are analyzed below: Year Ended December 31, 2023 2022 United States Federal Income Tax Rate 21.00 % 21.00 % State Taxes, Net of Federal Benefit 13.26 (2.59) Non-deductible R&D Expenses (3.49) — Contingent Consideration (3.36) — GILTI Inclusion (1.12) — Other Permanent Differences (0.65) (9.24) Change in Valuation Allowance (27.61) (9.53) Research and Development Credits 0.24 0.58 Tax Rate Differential 0.32 2.89 True Up Credit (0.08) — Other 0.76 (0.26) Effective Tax Rate Expense (0.73) % 2.85 % The Company’s deferred tax assets and liabilities consist of the following: Year Ended December 31, 2023 2022 Net Deferred Tax Liability: Net Operating Loss Carryforwards $ 25,982,646 $ 22,809,667 Research and Development Credit Carryforwards 2,955,627 2,925,890 Capitalized Research and Development 4,743,068 4,606,902 Stock-Based Compensation 784,366 782,355 Cash Versus Accrual Adjustments 77,729 336,360 Total Deferred Tax Assets 34,543,436 31,461,174 Valuation Allowance (33,025,829) (29,593,286) Net Deferred Tax Asset 1,517,607 1,867,888 Depreciation and Amortization — (477) In-Process Research and Development (2,297,047) (2,556,532) Net Deferred Tax Liability $ (779,440) $ (689,121) As of December 31, 2023, the Company has federal and state net operating loss carryforwards of approximately $90.2 million and $63.6 million, respectively, to offset future federal and state taxable income. Federal NOL carryforwards generated during the years ended December 31, 2017 and prior totaling $46.1 million will expire at various dates through 2037, and state NOL carryforwards totaling $63.6 million will expire at various dates through 2042. Federal NOL carryforwards generated during the years ended December 31, 2018 and forward totaling $44.1 million will carry forward indefinitely, but their utilization will be limited to 80% of taxable income. The Company has foreign net operating loss carryforwards of $12.2 million as of December 31, 2023, which can be carried forward indefinitely. As of December 31, 2023, the Company also has federal and state research and development tax credit carryforwards of approximately $2.5 million and $0.5 million, respectively, to offset future income taxes, which expire at various times through 2042. The federal and state net operating loss and research tax credit carryforwards may be subject to the limitations provided in the Internal Revenue Code (“IRC”) Sections 382 and 383. Approximately $0.6 million of the federal net operating loss attributable to Jade is subject to a Section 382 limitation. Jade’s carryover of its research and development credits will be subject to the Section 383 limitation. The Company files United States federal income tax returns and income tax returns in the Commonwealth of Massachusetts, California, North Carolina and Utah, as well as foreign tax returns for its subsidiaries in Austria and Australia. The Company is not under examination by any jurisdiction for any tax year. The Company has recorded a valuation allowance against its United States and foreign deferred tax assets in each of the years ended December 31, 2023, and 2022 because the Company’s management believes that it is more likely than not that these assets will not be realized. The valuation allowance increased by approximately $3.4 million and $1.3 million during the years ended December 31, 2023 and 2022, respectively, primarily as a result of the increase in net operating losses and credits, adjustments for accrual to cash basis items, and capitalized research and development expenses. As of December 31, 2023 and 2022, the Company had no unrecognized tax benefits or related interest and penalties accrued. The Company will recognize interest and penalties related to income taxes in income tax expense. The Company has not, as yet, conducted a study of R&D credit carryforwards, which are fully reserved for. This study may result in an adjustment to the Company’s R&D credit carryforwards and related valuation allowance, however, until a study is completed and any adjustment is known, no amounts are being presented as an uncertain tax position. The net operating loss and tax credit carryforwards are subject to review by the Internal Revenue Service in accordance with the provisions of Section 382 of the Internal Revenue Code. Under this Internal Revenue Code section, substantial changes in the Company’s ownership may limit the amount of net operating loss carryforwards that could be utilized annually in the future to offset the Company’s taxable income. Specifically, this limitation may arise in the event of a cumulative change in ownership of the Company of more than 50% within a three-year period. Any such annual limitation may significantly reduce the utilization of the Company’s net operating loss carryforwards before they expire. The closing of the Company’s initial public offering, alone or together with transactions that have occurred or that may occur in the future, may trigger an ownership change pursuant to Section 382, which could limit the amount of research and development tax credit and net operating loss carryforwards that could be utilized annually in the future to offset the Company’s taxable income, if any. Any such limitation as the result of the Company’s additional sales of common stock by the Company could have a material adverse effect on the Company’s results of operations in future years.

Commitments and Contingencies

Commitments and Contingencies	12 Months Ended
	Dec. 31, 2023
Commitments and Contingencies Disclosure [Abstract]
Commitments and Contingencies	Commitments and Contingencies Leases The Company is a party to three real property operating leases for the rental of office space. In February 2022, the Company entered into an 18-month lease in Encinitas, California (the "Encinitas Lease"), which is now used for its corporate headquarters. The Encinitas Lease commenced in May 2022 and was amended to extend its term through April 30, 2025. The Company recorded a right-of-use (ROU) asset and lease liability upon lease commencement and lease amendment in May 2022 and November 2023, respectively. In May 2022, the Company entered into a 12-month lease for office space in Adelaide Australia (the "Adelaide Lease") which expired in May 2023. Following expiration, the landlord agreed to extend the Adelaide Lease on a month-month basis, whereby the Company must provide 90-day notice of termination. The Adelaide Lease is a short-term lease which is exempt for ROU asset and lease liability reporting. The Company also entered into a lease for 910 square feet of office space in Vienna, Austria ("the Vienna Lease"). The Vienna Lease commenced on October 15, 2023 with a term of 5 years through October 14, 2028. The Company recorded a ROU asset and lease liability upon lease commencement in October 2023. Operating lease assets and liabilities are recognized at the lease commencement date at the present value of lease payments to be paid. Operating lease assets represent the Company’s right to use an underlying asset and are based upon the operating lease liabilities adjusted for prepayments or accrued lease payments. To determine the present value of lease payments to be paid, the Company estimated incremental secured borrowing rates corresponding to the maturities of the leases. The Company estimated a rate of 8.50% based on prevailing financial market conditions, comparable company and credit analysis, and management judgment. The Company recognizes expense for its leases on a straight-line basis over the lease term. Operating lease expense, consisting of the reduction of the right-of-use asset and the imputed interest on the lease liability, totaled $0.2 million and $0.1 million for the years ended December 31, 2023 and 2022, respectively. Future annual minimum lease payments were as follows as of December 31, 2023: Operating Leases 2024 $ 53,966 2025 27,566 2026 14,366 2027 14,372 2028 11,373 Less: Amounts Representing Interest (14,755) Lease Liabilities $ 106,890 License Agreements The Company is a party to seven license agreements as described below. These license agreements require the Company to pay or receive royalties or fees to or from the licensor based on revenue or milestones related to the licensed technology. On July 2, 2013, the Company (through its subsidiary, Kiora Pharmaceuticals GmbH) entered into a patent and know-how assignment agreement with 4SC Discovery GmbH (“4SC”) transferring to it all patent rights and know-how to the compound used in KIO-101 and KIO-104. The Company is responsible for paying royalties of 3.25% on net sales of KIO-101, KIO-104 or any other therapeutic product that uses the compound. On July 2, 2013, the Company (through its subsidiary, Kiora Pharmaceuticals, GmbH) entered into an out-license agreement with 4SC granting 4SC the exclusive worldwide right to commercialize the compound used in KIO-101 and KIO-104 for rheumatoid arthritis and inflammatory bowel disease, including Crohn’s Disease and Ulcerative Colitis. The Company is eligible to receive milestone payments totaling up to €155 million, upon and subject to the achievement of certain specified developmental and commercial milestones. We have not received any milestones from 4SC. In addition, the Company is eligible to receive royalties of 3.25% on net sales of any product commercialized by 4SC using the compound in KIO-101 and KIO-104. On September 12, 2013, the Company (through its subsidiary, Jade Therapeutics, Inc.) entered into an agreement with Lineage Cell Therapeutics, Inc. (“Lineage”), formerly known as BioTime, Inc. granting to the Company the exclusive worldwide right to commercialize cross-linked thiolated carboxymethyl hyaluronic acid (“modified HA”) for ophthalmic treatments in humans. The agreement requires the Company to pay an annual fee of $30,000 and a royalty of 6% on net sales of KIO-201 to Lineage based on revenue relating to any product incorporating the modified HA technology. The agreement expires when patent protection for the modified HA technology lapses in August 2027. On November 17, 2014, the Company (through its subsidiary Kiora Pharmaceuticals GmbH) entered into an intellectual property and know-how licensing agreement with Laboratoires Leurquin Mediolanum S.A.S. (“Mediolanum”) for the commercialization of KIO-101 in specific territories. Under the Mediolanum agreement, the Company out-licensed rights to commercialize KIO-101 for uveitis, dry eye and viral conjunctivitis in Italy, and France. This agreement was amended on December 10, 2015 to also include Belgium and The Netherlands. Under the Mediolanum agreement, Mediolanum is obligated to pay up to approximately €20.0 million in development and commercial milestones and a 7% royalty on net sales of KIO-101 in the territories through the longer of the expiration of the valid patents covering KIO-101 or 10 years from the first commercial sale. The royalty is reduced to 5% after patent expiry. On September 7, 2023, the Company (through its subsidiary Kiora Pharmaceuticals GmbH) agreed to a settlement agreement with Mediolanum to terminate the existing out-licensing rights by Mediolanum to commercialize KIO-101 for uveitis, dry eye and viral conjunctivitis in Italy, France, Belgium and Netherlands including all related commercial milestone payments and royalty obligations. The Company agreed to pay a termination fee of $0.1 million, of which $50,000 was paid upon execution of the agreement, and $50,000 is payable on the one year anniversary of the termination and is accrued for in the accompanying condensed consolidated financial statements. On September 26, 2018, the Company entered into an intellectual property licensing agreement (the “SentrX Agreement”) with SentrX, a veterinary medical device company that develops and manufactures veterinary wound care products. Under the SentrX Agreement, the Company in-licensed the rights to trade secrets and know-how related to the manufacturing of KIO-201. The SentrX Agreement enables the Company to pursue a different vendor with a larger capacity for manufacturing and an FDA-inspected facility for commercialization of a product for human use. Under the SentrX Agreement, SentrX is eligible to receive milestone payments totaling up to $4.75 million, upon and subject to the achievement of certain specified developmental and commercial milestones. On June 7, 2023, the Company entered into an amendment agreement (the "SentrX First Amendment") whereby SentrX removed the Company's obligation to make any further payments, milestone or otherwise.The term of the amendment agreement remains unchanged, which is until the product is no longer in the commercial marketplace. In addition, on June 7, 2023, the Company entered into a new exclusive license agreement (the "New SentrX Agreement") with SentrX, whereby the Company out-licensed certain KIO-201 patents for use in animal health and veterinary medicine. Under the New SentrX Agreement, SentrX is obligated to pay the Company a flat low single-digit royalty on net sales, and is effective until the last licensed patent terminates. On May 1, 2020, the Company (through its subsidiary, Bayon Therapeutics, Inc.) entered into an agreement with the University of California (“UC”) granting to the Company the exclusive rights to its pipeline of photoswitch molecules. The agreement requires the Company to pay an annual fee to UC of $5,000, as well as payments to UC upon the achievement of certain development milestone and royalties based on KIO-301 revenue. The Company is obligated to pay royalties on net sales of two percent (2%) of the first $250 million of net sales, one and a quarter percent (1.25%) of net sales between $250 million and $500 million, and one half of one percent (0.5%) of net sales over $500 million. The agreement expires on the date of the last-to-expire patent included in the licensed patent portfolio which is January 2030. On May 1, 2020, the Company (through its subsidiary, Bayon Therapeutics, Inc.) entered into an agreement with Photoswitch Therapeutics, Inc. (“Photoswitch”) granting to the Company access to certain patent applications and IP rights with last-to-expire patent terms of January 2030. The agreement calls for payments to Photoswitch upon the achievement of certain development and upon first commercial sale of the product. On October 30, 2023, the Company, through its subsidiary, Bayon Therapeutics, Inc., entered into an agreement with the University of California (“UC”) to amend its licensing agreement dated May 1, 2020 effective November 5, 2023, granting the Company exclusive rights to a patent application covering specific formulations of KIO-301, which was previously jointly owned by UC and Bayon. Further, Bayon has the ability to assign or transfer the agreement providing written notice is given within at least 15 days prior to any such assignment, providing written assignment agreement by successor within 30 days, and by paying an assignment fee of $30,000 within 30 days of the assignment. Per the terms of the agreement, upon execution of the amendment the Company was required to pay UC $15,000.

Employee Benefit Plans

Employee Benefit Plans	12 Months Ended
	Dec. 31, 2023
Postemployment Benefits [Abstract]
Employee Benefit Plans	Employee Benefit Plans The Company has an employee benefit plan for its United States-based employees under Section 401(k) of the Internal Revenue Code. The Plan allows all eligible employees to make contributions up to a specified percentage of their compensation. Under the Plan, the Company may, but is not obligated to, match a portion of the employee contribution up to a defined maximum. The Company made no matching contribution for the year ended December 31, 2023. As a result of the 401(k) plan compliance review for the year ended December 31, 2021, the Company contributed approximately $29.2 thousand to eligible participants during the third quarter of 2022. As of December 31, 2022, the Company accrued an additional estimate of $8.5 thousand for contributions that were expected to be owed as a result of the 401(k) plan compliance review, however upon completion of the review no additional payments were owed and the accrual was reversed in the first quarter of 2023. No payments are accrued for the 401(k) plan compliance review for the year ended December 31, 2023.

Subsequent Events

Subsequent Events	12 Months Ended
	Dec. 31, 2023
Subsequent Events [Abstract]
Subsequent Events	Subsequent Events On January 25, 2024, the Company entered into a strategic development and commercialization agreement with Théa Open Innovation (TOI), a sister company of the global ophthalmic specialty company Laboratoires Théa (Théa). Under the agreement, Kiora granted TOI exclusive worldwide development and commercialization rights, excluding certain countries in Asia, to KIO-301 for the treatment of degenerative retinal diseases. In exchange, Kiora will receive an upfront, payment of $16 million; up to $285 million upon achievement of pre-specified clinical development, regulatory and commercial milestones; tiered royalties of up to low 20% on net sales; and reimbursement of certain KIO-301 research and development expenses. On January 31, 2024, the Company terminated its Equity Line of Credit with Lincoln Park. On February 05, 2024, the Company entered into a private placement with Maxim Group LLC serving as placement agent for 15,800,000 shares of common stock, pre-funded warrants to purchase up to 11,354,237 shares of common stock, and accompanying Tranche A and Tranche B warrants to purchase up to an aggregate of 49,374,590 shares of common stock. The total net proceeds from the private placement were approximately $13.8 million. The exercise of the accompanying warrants (excluding the pre-funded warrants) is subject to shareholder approval. The Tranche A warrants are exercisable for up to 24,687,295 shares of common stock at an exercise price of $0.6076 per share for an aggregate of up to approximately $15 million and will expire at the earlier of (i) 30 days following the announcement of full data (expected in the second quarter of 2025) from the Company's Phase 2 clinical trial (ABACUS-2) of KIO-301 in patients with retinitis pigmentosa and the daily VWAP of the Company's common stock equaling or exceeding $1.1048 per share for 30 consecutive trading days following the announcement and (ii) five years from the date of shareholder approval of the warrants. The Tranche B warrants are exercisable for up to 24,687,295 shares of common stock at an exercise price of $0.6076 per share for an aggregate of up to approximately $15 million and will expire at the earlier of (i) 30 days following the announcement of topline data (expected in 2026) from the planned Phase 2 trial of KIO-104 in posterior non-infectious uveitis and the daily VWAP of the Company's common stock equaling or exceeding $1.3810 per share for 30 consecutive trading days following the announcement and (ii) five years from the date of shareholder approval of the warrants. In February 2024, 914,155 Class C warrants were exercised at $0.5231 per share for aggregate proceeds of approximately $0.4 million. Additionally, 1,836,402 Class D warrants were exercised at $0.5231 per share for aggregate proceeds of approximately $1.0 million. In March 2024, the Company made a payment of $0.7 million to Regents of the University of California related to a sublicense fee owed as a result of the TOI transaction.

Summary of Significant Accoun_2

Summary of Significant Accounting Policies (Policies)	12 Months Ended
	Dec. 31, 2023
Accounting Policies [Abstract]
Adoption of Accounting Standards	Adoption of Accounting Standards In August 2020, the Financial Accounting Standards Board (FASB) issued Accounting Standards Update (ASU) 2020-06, Debt—Debt with Conversion and Other Options (Subtopic 470-20) and Derivatives and Hedging—Contracts in Entity's Own Equity (Subtopic 815-40): Accounting for Convertible Instruments and Contracts in an Entity's Own Equity. This guidance removes the liability and equity separation models for convertible instruments with a cash conversion feature or beneficial conversion feature. As a result, companies will more likely account for a convertible debt instrument wholly as debt, and for convertible preferred stock wholly as preferred stock (i.e., as a single unit of account). In addition, the guidance simplifies the settlement assessment that issuers perform to determine whether a contract in their own equity qualifies for equity classification. Finally, the guidance requires entities to use the if-converted method to calculate earnings per share for all convertible instruments. The Company adopted ASU 2020-06 on January 1, 2022. The adoption of ASU 2020-06 did not have a material effect for the Company. In May 2021, the FASB issued ASU 2021-04, Earnings Per Share (Topic 260), Debt—Modifications and Extinguishments (Subtopic 470-50), Compensation—Stock Compensation (Topic 718), and Derivatives and Hedging—Contracts in Entity’s Own Equity (Subtopic 815-40) to clarify an issuer’s accounting for certain modifications or exchanges of freestanding equity-classified written call options (for example, warrants) that remain equity classified after modification or exchange. Specifically, the ASU provides a principles-based framework to determine whether an issuer should recognize the modification or exchange as an adjustment to equity or an expense. The guidance is effective for annual reporting periods beginning after December 15, 2021, and interim periods within those fiscal years. The Company adopted ASU 2021-04 on January 1, 2022. The adoption of ASU 2021-04 did not have a material effect for the Company. In November 2021, the FASB issued ASU 2021-10, which requires business entities to disclose information about certain government assistance they receive. Such disclosure requirements include the nature of the transactions and the related accounting policy used, the line items on the balance sheet and income statement that are affected and the amounts applicable to each financial statement line item and significant terms and conditions of the transactions. ASU 2021-10 was effective for the Company January 1, 2022. The adoption of ASU 2021-10 did not have a material effect for the Company. In June 2016, the FASB issued ASU No. 2016-13, Financial Instruments - Credit Losses, to improve financial reporting by requiring timely recording of credit losses on loans and other financial instruments held by financial institutions and other organizations. The ASU requires the measurement of all expected credit losses for financial assets held at the reporting date based on historical experience, current conditions and reasonable and supportable forecasts. This guidance became effective for the Company on January 1, 2023. The adoption of ASU 2016-13 did not have a material effect for the Company. Accounting Pronouncements Pending Adoption In December 2023, the FASB issued ASU 2023-07, Segment Reporting (Topic 280) - Improvements to Reportable Segment Disclosures. The new standard requires a company to disclose incremental segment information on an annual and interim basis, including significant segment expenses and measures of profit or loss that are regularly provided to the chief operating decision maker (CODM). The standard is effective for us beginning in fiscal year 2024 and interim periods within fiscal year 2025, with early adoption permitted. We do not expect to early adopt the new standard. We are currently evaluating the impact of ASU 2023-07 on the consolidated financial statements and related disclosures and will adopt the new standard using a retrospective approach. In December 2023, the FASB also issued ASU 2023-09, Income Taxes (Topic 740) - Improvements to Income Tax Disclosures. The new standard requires a company to expand its existing income tax disclosures, specifically related to the rate reconciliation and income taxes paid. The standard is effective for us beginning in fiscal year 2025, with early adoption permitted. We do not expect to early adopt the new standard. The new standard is expected to be applied prospectively, but retrospective application is permitted. We are currently evaluating the impact of ASU 2023-09 on the consolidated financial statements and related disclosures.
Basis of Presentation and Principles of Consolidation	Basis of Presentation and Principles of Consolidation The accompanying Consolidated Financial Statements include the accounts of the Company and its subsidiaries, Jade Therapeutics, Inc. (“Jade”), Kiora Pharmaceuticals, GmbH (“Kiora GmbH”) (formerly known as Panoptes Pharma Ges.m.b.H or “Panoptes”) (effective December 18, 2020 when the Company acquired all of the capital stock of Panoptes), Bayon Therapeutics, Inc. ("Bayon") (effective October 21, 2021 when the Company acquired all of the capital stock of Bayon), and Kiora Pharmaceuticals Pty Ltd (“Kiora Pty”) (formerly known as Bayon Therapeutics Pty Ltd), collectively referred to as “the Company”. All inter-company balances and transactions have been eliminated in consolidation. These Consolidated Financial Statements have been prepared in accordance with accounting principles generally accepted in the United States (“U.S. GAAP”).
Use of Estimates	Use of Estimates The preparation of financial statements in conformity with U.S. GAAP requires management to make significant estimates and assumptions that affect the reported amounts of assets and liabilities, and disclosure of contingent assets and liabilities, at the date of the financial statements, and the reported amounts of expenses during the reporting periods. The Company makes significant estimates and assumptions in recording the accruals for the Company’s clinical trial and research activities, establishing the useful lives of intangible assets and property and equipment, conducting impairment reviews of in-process research and development (IPR&D), stock-based compensation, assumptions used to value warrants including warrant modifications and inducements, and contingent considerations payable. The Company bases its estimates on historical experience and various other assumptions that it believes to be reasonable under the circumstances. Although the Company monitors and regularly assesses these estimates, actual results could differ significantly from these estimates. The Company records changes in estimates in the period that it becomes aware of the change.
Foreign Currency Translation	Foreign Currency Translation Operations of Kiora GmbH are conducted in euros, which represent its functional currency. Operations of Kiora Pty are conducted in Australian dollars, which represent its functional currency. Balance sheet accounts of such subsidiaries were translated into U.S. dollars at the exchange rate in effect at the balance sheet date and income statement accounts were translated to the average rate of exchange prevailing during the period. Translation adjustments resulting from this process, are included in accumulated other comprehensive loss on the Consolidated Balance Sheets and a component of other comprehensive income (loss) on the Consolidated Statements of Operations and Comprehensive Loss.
Cash and Cash Equivalents and Restricted Cash	Cash and Cash Equivalents and Restricted Cash
Property and Equipment	Property and Equipment Property and equipment is stated at cost less accumulated depreciation. Depreciation is provided for on a straight-line basis over the estimated useful life of 2 to 5 years for all assets. Maintenance and repair costs are expensed as incurred. The Company reviews its property and equipment whenever events or changes in circumstances indicate that the carrying value of certain assets might not be recoverable and recognizes an impairment loss when it is probable that the estimated cash flows are less than the carrying value of the asset.
Impairment of Long-Lived Assets	Impairment of Long-Lived Assets The Company evaluates potential impairment of long-lived assets and long-lived assets to be disposed of and considers whether long-lived assets held for use have been impaired whenever events or changes in circumstances indicate that the related carrying amount may not be recoverable, or that the period of their recovery may have changed. Management makes significant estimates and assumptions regarding future sales, cost trends, productivity and market maturity in order to test for impairment. Management reports those long-lived assets to be disposed of and assets held for sale at the lower of carrying amount or fair value less cost to sell. Based on current facts, estimates and assumptions, management believes that no assets are impaired at December 31, 2023. There is no assurance that management’s estimates and assumptions will not change in future periods.
Research and Development Expenses	Research and Development Expenses The Company expenses research and development (“R&D”) expenditures as incurred. R&D expenses are comprised of costs incurred in performing R&D activities, including salaries, benefits, facilities, research-related overhead, sponsored research costs, contracted services, license fees, expenses related to generating, filing, and maintaining intellectual property and other external costs. Because the Company believes that, under its current process for developing its products, the viability of the products is essentially concurrent with the establishment of technological feasibility, no costs have been capitalized to date.
In-Process Research and Development	In-Process Research and Development
Accrued Clinical Expenses	Accrued Clinical Expenses As part of the Company’s process of preparing the Consolidated Financial Statements, the Company is required to estimate its accrued expenses. This process includes reviewing open contracts and purchase orders, communicating with its applicable personnel to identify services that have been performed on its behalf and estimating the level of service performed and the associated costs incurred for the service when the Company has not yet been invoiced or otherwise notified of actual costs. The majority of the Company’s service providers invoice monthly in arrears for services performed. The Company makes estimates of its accrued expenses as of each balance sheet date in the financial statements based on facts and circumstances known at the time. The Company periodically confirms the accuracy of these estimates with the service providers and makes adjustments if necessary.
Business Segment and Geographical Information	Business Segment and Geographical Information The Company identifies operating segments as components of the enterprise for which separate discrete financial information is available for evaluation by the chief operating decision maker, or decision-making group, in making decisions on how to allocate resources and assess performance. The Company views its operations and manages its business as fully integrated and operating in one business segment (research and development), and the Company operates in three geographic areas.
Income Taxes	Income Taxes The Company will record a deferred income tax asset and liability for the expected future income tax consequences of events that have been recognized in the Company’s consolidated financial statements and income tax returns. The Company will record a deferred income tax asset and liability based on differences between the financial statement carrying, or “book”, amounts of assets and liabilities, and the tax bases of the assets and liabilities using the enacted income tax regulations in effect in the years in which the differences are expected to reverse. A valuation allowance against deferred income tax asset will be recorded if, based on the weight of available evidence, it is more likely than not that some or all of the deferred income tax assets will not be realized. As of December 31, 2023 and 2022, all of the Company’s net deferred income tax assets were subject to a full valuation allowance. As of December 31, 2023 and 2022, the Company has a net deferred tax liability of $0.8 million and $0.7 million, respectively.
Warrant Liability	Warrant Liability The Company classifies warrants to purchase shares of its common stock as a liability on its Consolidated Balance Sheets when the warrant is a free-standing financial instrument that may require the Company to transfer cash consideration upon exercise and that cash transfer event would be out of the Company’s control. Such a “warrant liability” is initially recorded at fair value on date of grant using the Black-Scholes model, and it is subsequently re-measured to fair value at each subsequent balance sheet date. Changes in the fair value of the warrant are recognized as a component of other income (expense), net in the Consolidated Statements of Operations and Comprehensive Loss. The Company will adjust the liability for changes in fair value until the earlier of the exercise or expiration of the warrant or meeting the requirements to be reclassified to equity. For warrants that do not meet the criteria of a liability warrant and are classified on the Company’s Consolidated Balance Sheets as equity instruments, the Company uses the Black-Scholes model to measure the value of the warrants at issuance and then applies the relative fair-value of the equity transaction between common stock, preferred stock and warrants. Common stock and equity-classified warrants each are considered permanent equity.
Refunds for Research and Development	Refunds for Research and Development
Concentration of Credit Risk and Off-Balance-Sheet Risk	Concentration of Credit Risk and Off-Balance-Sheet Risk Financial instruments that potentially subject the Company to significant concentrations of credit risk consist principally of cash and cash equivalents. The Company invests cash in accredited financial institutions and cash equivalents in widely held money market funds. Consequently, such funds are subject to minimal credit risk. The Company has no significant off-balance-sheet risk such as foreign exchange contracts, option contracts, or other foreign hedging arrangements.
Comprehensive Loss	Comprehensive Loss Comprehensive loss is defined as the change in stockholders’ equity during a period from transactions and other events and circumstances from non-owner sources. The foreign currency translation adjustments are the Company’s only component of other comprehensive loss.
Stock-Based Compensation	Stock-Based Compensation Stock-based compensation represents the cost related to stock-based awards granted to employees and others. The Company measures stock-based compensation cost to employees and non-employees at grant date, based on the estimated fair value of the award. Compensation cost for employee awards is recognized as expense on a straight-line basis over the employee requisite service period. The Company estimates the fair value of stock options using the Black-Scholes valuation model. The Company recorded compensation expense for non-employee awards with graded vesting using the accelerated expense attribution method. The Company’s policy is to record forfeitures as they occur.
Net Loss per Share - Basic and Diluted	Net Loss per Share – Basic and Diluted Basic and diluted net loss per share is computed by dividing net loss available to common shareholders by the weighted-average number of common shares outstanding for the period, which, for basic net loss per share, does not include the weighted-average unvested restricted common stock that has been issued but is subject to forfeiture of 229,373 shares for year ended December 31, 2023 and 30,000 shares for the year ended December 31, 2022.
Related-Party Transactions	Related-Party Transactions During the year ended December 31, 2023, the Company entered into certain related-party transactions, making payments for services to one vendor, three employees and fifteen consultants, all of whom also are stockholders of the Company. These transactions generally involve a stockholder or option holder of the Company to whom the Company also makes payments during the year, typically as a consultant or a service provider. The Company made payments of approximately $0.1 million for services to the related party vendor Ora, Inc. where one of the Company’s directors is an executive and who the Company has engaged for KIO-301 clinical study services. The Company made payments of $0.5 million to consultants for advisory services. The Company employs a family member of our Chief Development Officer and incurred approximately $0.1 million in employment related costs. Additionally, in December 2023, in connection with the acquisition of Bayon Therapeutics, Inc., the Company issued $0.5 million in milestone payments to former shareholders of Bayon Therapeutics, Inc., including our President and CEO and Chief Development Officer.
Fair Value Measurements	Fair Value Measurements Fair value accounting is applied to all financial assets and liabilities that are recognized or disclosed at fair value in the consolidated financial statements on a recurring basis (at least annually). As of December 31, 2023 and 2022, the carrying amounts of cash equivalents, tax receivables, accounts payable, and accrued liabilities approximated their fair values due to their relatively short maturities. Assets and liabilities recorded at fair value on a recurring basis on the consolidated balance sheets are categorized based upon the level of judgment associated with the inputs used to measure their fair values. Fair value is defined as the exchange price that would be received for an asset or an exit price that would be paid to transfer a liability in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. Valuation techniques used to measure fair value must maximize the use of observable inputs and minimize the use of unobservable inputs. The authoritative guidance on fair value measurements establishes a three-tier fair value hierarchy for disclosure of fair value measurements as follows: Level 1 - Observable inputs such as unadjusted, quoted prices in active markets for identical assets or liabilities at the measurement date. Level 2 - Inputs (other than quoted prices in active markets included in Level 1) are either directly or indirectly observable for the asset or liability. These include quoted prices for similar assets or liabilities in active markets and quoted prices for identical or similar assets or liabilities in markets that are not active. Level 3 - Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities.

Summary of Significant Accoun_3

Summary of Significant Accounting Policies (Tables)	12 Months Ended
	Dec. 31, 2023
Accounting Policies [Abstract]
Shares of common stock that may potentially be issued in the future	All shares of Common Stock that may potentially be issued in the future are as follows: Year Ended December 31, 2023 2022 Common Stock Warrants 13,064,299 1,597,606 Employee Stock Options 812,945 84,751 Restricted Stock 229,373 30,000 Preferred Stock 381,832 52 Total Shares of Common Stock Issuable 14,488,449 1,712,409
Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis	There were no assets or liabilities valued at fair value using Level 1 or 2 inputs. The following table provides information for assets and liabilities measured at fair value on a recurring basis using Level 3 inputs: December 31, 2023 December 31, 2022 Contingent Consideration: Current — 322,385 Noncurrent 5,128,959 3,309,175 Total Contingent Consideration $ 5,128,959 $ 3,631,560

Fair Value (Tables)

Fair Value (Tables)	12 Months Ended
	Dec. 31, 2023
Fair Value Disclosures [Abstract]
Schedule of fair value unobservable level 3 inputs	Below is the list of obligations for each relevant transaction as of December 31, 2023 as follows: Acquisition Milestone Achievement Condition Contingent Consideration Payable Bayon Successful completion of Phase 2 $ 1.0 million Successful completion of Phase 3 $ 4.0 million FDA approval $ 1.7 million Panoptes Beginning of Phase 3 $ 4.8 million FDA approval $ 4.8 million Jade FDA approval $ 2.2 million Valuation Technique Unobservable Inputs December 31, 2023 December 31, 2022 Discounted cash flow Payment discount rate 13.1% 14.7% Bayon Payment period 2025 - 2027 2023 - 2028 Panoptes Payment period 2026 - 2028 2024 - 2028 Jade Payment period 2027 2026 Bayon Probability of Success for milestone 42% - 71% 17% - 67% Panoptes Probability of Success for milestone 30% - 33% 17% - 36% Jade Probability of Success for milestone 56% 56% Management completed, with the assistance of a third party valuation firm, a quantitative assessment of in-process R&D as of August 31, 2023, the Company's annual impairment test date, which includes the following unobservable Level 3 inputs: Valuation Technique Unobservable Inputs Input Discount Rate KIO-101 Relief from Royalty Method Probability of success for next development phase 17% 30% KIO-104 Multi-Period Excess Earnings Method Probability of success for next development phase 17% to 36% 25% KIO-201 Relief from Royalty Method Probability of success for next development phase 17% to 46% 30% KIO-301 Multi-Period Excess Earnings Method Probability of success for next development phase 17% to 67% 25%

Property and Equipment (Tables)

Property and Equipment (Tables)	12 Months Ended
	Dec. 31, 2023
Property, Plant and Equipment [Abstract]
Schedule of property and equipment	Property and equipment at December 31, 2023 and 2022 consists of the following: Estimated Useful 2023 2022 Laboratory Equipment 3 $ 11,832 $ 88,399 Office Equipment 3 2,521 3,409 Office Furniture 5 — 58,119 Leasehold Improvements 2 — 22,569 Total Property and Equipment, Gross 14,353 172,496 Less Accumulated Depreciation 6,289 117,319 Total Property and Equipment, Net $ 8,065 $ 55,177

Accrued Expenses (Tables)

Accrued Expenses (Tables)	12 Months Ended
	Dec. 31, 2023
Accrued Liabilities [Abstract]
Schedule of accrued expenses	Accrued expenses consist of the following: December 31, 2023 2022 Payroll and Benefits $ 875,254 $ 1,312,443 Professional Fees 43,387 282,721 Clinical Trials 397,465 57,020 Other 64,560 183,750 Total Accrued Expenses $ 1,380,666 $ 1,835,934

Intangible Assets and In-Proc_2

Intangible Assets and In-Process R&D (Tables)	12 Months Ended
	Dec. 31, 2023
Goodwill and Intangible Assets Disclosure [Abstract]
Schedule of intangible assets and in-process R&D	Intangible assets and in-process R&D at December 31, 2023 and 2022 consists of the following: Estimated Useful 2023 2022 Trade Secrets 10 $ 250,000 $ 250,000 Less: Accumulated Amortization (131,250) (106,250) Intangible Assets, Net 118,750 143,750 In-Process R&D 8,695,100 10,599,414 Total Intangible Assets and In-Process R&D, Net $ 8,813,850 $ 10,743,164
Schedule of future annual intangible amortization	Expected future amortization expense is as follows for the years ending December 31,: Intangible Assets 2024 $ 25,000 2025 25,000 2026 25,000 2027 25,000 2028 18,750 Total $ 118,750

Warrants (Tables)

Warrants (Tables)	12 Months Ended
	Dec. 31, 2023
Warrants
Schedule of warrant activity	At December 31, 2023 and 2022, the following warrants were outstanding: Number of Weighted Weighted Outstanding at December 31, 2021 168,932 $ 199.65 3.42 Issued 2,159,395 7.38 2.55 Exercised (719,609) 5.06 Expired (11,112) 900.00 Outstanding at December 31, 2022 1,597,606 $ 21.22 3.07 Issued 11,605,596 0.55 3.02 Exercised (66,400) 5.97 Expired (72,503) 108.80 Outstanding at December 31, 2023 13,064,299 $ 2.40 2.43

Equity Incentive Plan (Tables)

Equity Incentive Plan (Tables)	12 Months Ended
	Dec. 31, 2023
Equity Incentive Plan
Schedule of stock option activity	The following is a summary of stock option activity for the years ended December 31, 2023 and 2022: Number of Weighted Average Weighted Average Outstanding at December 31, 2021 12,954 $ 426.25 5.56 Granted 78,641 8.49 Expired (14) 842.57 Forfeited (6,830) 446.34 Outstanding at December 31, 2022 84,751 $ 36.92 9.59 Exercisable at December 31, 2022 4,939 $ 442.52 7.27 Vested and Expected to Vest at December 31, 2022 84,751 $ 36.92 9.59 Granted 764,400 1.11 Expired (927) 373.32 Forfeited (35,279) 5.08 Outstanding at December 31, 2023 812,945 $ 4.26 9.56 Exercisable at December 31, 2023 173,394 $ 13.79 9.46 Vested and Expected to Vest at December 31, 2023 812,945 $ 4.26 9.56
Schedule of weighted average assumptions	For the years ended December 31, 2023 and 2022, the fair value of each option grant has been estimated on the date of grant using the Black-Scholes Option Pricing Model with the following weighted-average assumptions: 2023 2022 Risk-Free Interest Rate 3.95% - 4.61% 2.42% Expected Life 5.0 - 5.6 years 5.0 years Expected Average Volatility 141.0% - 145.2% 140% Expected Dividend Yield 0% 0%
Schedule of restricted stock activity	The following is a summary of restricted stock activity for the years ended December 31, 2023 and 2022: Number of Weighted-Average Weighted-Average Non-vested Outstanding at December 31, 2021 375 $ 261.47 1.09 Awarded 30,000 6.78 Released (248) 261.45 Forfeited (127) 261.51 Non-vested Outstanding at December 31, 2022 30,000 $ 6.78 2.79 Awarded 270,050 1.06 Released (67,377) 1.49 Forfeited (3,300) 3.83 Non-vested Outstanding at December 31, 2023 229,373 $ 1.64 2.57
Schedule of stock-based compensation expense	The total stock-based compensation expense for employees and non-employees is included in the accompanying Consolidated Statements of Operations and as follows: Year Ended December 31, 2023 2022 General and Administrative $ 345,488 $ 343,475 Research and Development 409,456 118,975 Total Stock-Based Compensation Expense $ 754,944 $ 462,450

Income Taxes (Tables)

Income Taxes (Tables)	12 Months Ended
	Dec. 31, 2023
Income Tax Disclosure [Abstract]
Schedule of components of loss before income taxes	The components of loss before income taxes are as follows: Year Ended December 31, 2023 2022 Domestic $ (9,384,178) $ (10,563,302) Foreign (3,039,399) (3,133,318) Total Loss Before Income Taxes $ (12,423,577) $ (13,696,620)
Schedule of components of income tax expense	The components of income tax expense (benefit) are as follows: Year Ended December 31, 2023 2022 Deferred Taxes: Federal $ (280,954) $ 4,954 State 371,273 (117,964) Total Deferred Taxes $ 90,319 $ (113,010) Income Tax Expense (Benefit) $ 90,319 $ (113,010)
Schedule of effective income tax rate reconciliation	The difference between the effective rate reflected in the provision for income taxes and the amounts determined by applying the applicable statutory U.S. tax rate are analyzed below: Year Ended December 31, 2023 2022 United States Federal Income Tax Rate 21.00 % 21.00 % State Taxes, Net of Federal Benefit 13.26 (2.59) Non-deductible R&D Expenses (3.49) — Contingent Consideration (3.36) — GILTI Inclusion (1.12) — Other Permanent Differences (0.65) (9.24) Change in Valuation Allowance (27.61) (9.53) Research and Development Credits 0.24 0.58 Tax Rate Differential 0.32 2.89 True Up Credit (0.08) — Other 0.76 (0.26) Effective Tax Rate Expense (0.73) % 2.85 %
Schedule of deferred tax assets and liabilities	The Company’s deferred tax assets and liabilities consist of the following: Year Ended December 31, 2023 2022 Net Deferred Tax Liability: Net Operating Loss Carryforwards $ 25,982,646 $ 22,809,667 Research and Development Credit Carryforwards 2,955,627 2,925,890 Capitalized Research and Development 4,743,068 4,606,902 Stock-Based Compensation 784,366 782,355 Cash Versus Accrual Adjustments 77,729 336,360 Total Deferred Tax Assets 34,543,436 31,461,174 Valuation Allowance (33,025,829) (29,593,286) Net Deferred Tax Asset 1,517,607 1,867,888 Depreciation and Amortization — (477) In-Process Research and Development (2,297,047) (2,556,532) Net Deferred Tax Liability $ (779,440) $ (689,121)

Commitments and Contingencies (

Commitments and Contingencies (Tables)	12 Months Ended
	Dec. 31, 2023
Commitments and Contingencies Disclosure [Abstract]
Schedule of maturities of lease Liabilities	Future annual minimum lease payments were as follows as of December 31, 2023: Operating Leases 2024 $ 53,966 2025 27,566 2026 14,366 2027 14,372 2028 11,373 Less: Amounts Representing Interest (14,755) Lease Liabilities $ 106,890

Business, Presentation and Re_2

Business, Presentation and Recent Accounting Pronouncements (Details)		3 Months Ended	12 Months Ended
	Sep. 27, 2022 shares	Mar. 25, 2024 USD ($)	Dec. 31, 2023 USD ($) segment_asset shares	Dec. 31, 2022 USD ($) shares	Sep. 26, 2022 shares
Accounting Policies [Line Items]
Number of anterior segment assets | segment_asset			2
Cash and cash equivalents | $			$ 2,454,684	$ 5,964,556
Accumulated deficit | $			$ 146,976,855	$ 134,462,959
Management's evaluation, forward looking period			24 months
Reverse stock split, conversion ratio	0.025
Common stock, authorized (in shares) | shares	50,000,000		50,000,000	50,000,000
Reverse stock split, number of fractional shares issued (in shares) | shares	0
Common stock, outstanding (in shares) | shares	1,079,045		7,705,640	1,796,472	43,163,123
Subsequent event
Accounting Policies [Line Items]
Cash receipts | $		$ 32,400,000

Summary of Significant Accoun_4

Summary of Significant Accounting Policies - Additional Information (Details)	1 Months Ended	12 Months Ended
	Dec. 31, 2023 USD ($) shares	Dec. 31, 2023 USD ($) director vendor segment employee consultant shares	Dec. 31, 2022 USD ($) shares
Accounting Policies [Line Items]
Restricted cash	$ 4,267	$ 4,267	$ 49,260
Tangible asset impairment		0
In-Process R&D Impairment		1,904,314	0
Business combination, finite-lived intangibles	8,700,000	$ 8,700,000	10,600,000
Business segment | segment		1
Geographic segments | segment		3
Deferred tax liabilities, net	779,440	$ 779,440	689,121
Unrecognized uncertain income tax	0	0	0
Tax receivable	$ 1,900,000	$ 1,900,000	$ 1,300,000
Unvested restricted common stock (in shares) | shares	229,373	229,373	30,000
Related party transactions, number of vendors | vendor		1
Related party transactions, number of employees | employee		3
Related party transactions, number of consultants | consultant		15
In-process R&D, fair value	$ 8,700,000	$ 8,700,000	$ 10,600,000
Consultant advisory services
Accounting Policies [Line Items]
Expenses from transactions with related party		500,000
Employment related costs
Accounting Policies [Line Items]
Expenses from transactions with related party	100,000
Ora, Inc | Clinical study services
Accounting Policies [Line Items]
Expenses from transactions with related party		$ 100,000
Related party transactions, number of directors | director		1
Bayon | Milestone payments to former shareholders
Accounting Policies [Line Items]
Expenses from transactions with related party	$ 500,000
Minimum
Accounting Policies [Line Items]
Estimated useful life (Years)	2 years	2 years
Maximum
Accounting Policies [Line Items]
Estimated useful life (Years)	5 years	5 years

Summary of Significant Accoun_5

Summary of Significant Accounting Policies - Net Loss per Share - Basic and Diluted (Details) - shares	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Total Shares of Common Stock Issuable (in shares)	14,488,449	1,712,409
Restricted Stock
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Total Shares of Common Stock Issuable (in shares)	229,373	30,000
Common Stock
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Total Shares of Common Stock Issuable (in shares)	13,064,299	1,597,606
Preferred Stock
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Total Shares of Common Stock Issuable (in shares)	381,832	52
Employee Stock Options
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Total Shares of Common Stock Issuable (in shares)	812,945	84,751

Summary of Significant Accoun_6

Summary of Significant Accounting Policies - Liabilities Measured At Fair Value Recurring Basis Using Level 3 (Details) - USD ($)	Dec. 31, 2023	Dec. 31, 2022
Contingent Consideration:
Current	$ 0	$ 322,385
Noncurrent	5,128,959	3,309,175
Recurring | Level 3
Contingent Consideration:
Current	0	322,385
Noncurrent	5,128,959	3,309,175
Total Contingent Consideration	$ 5,128,959	$ 3,631,560

Fair Value - Obligations for Ea

Fair Value - Obligations for Each Relevant Transaction (Details) - USD ($)	Dec. 31, 2023	Dec. 31, 2022
Business Acquisition [Line Items]
Contingent Consideration Payable	$ 0	$ 322,385
Bayon | Successful completion of Phase 2
Business Acquisition [Line Items]
Contingent Consideration Payable	1,000,000
Bayon | Successful completion of Phase 3
Business Acquisition [Line Items]
Contingent Consideration Payable	4,000,000
Bayon | FDA approval
Business Acquisition [Line Items]
Contingent Consideration Payable	1,700,000
Jade | FDA approval
Business Acquisition [Line Items]
Contingent Consideration Payable	2,200,000
Panoptes | FDA approval
Business Acquisition [Line Items]
Contingent Consideration Payable	4,800,000
Panoptes | Beginning of Phase 3
Business Acquisition [Line Items]
Contingent Consideration Payable	$ 4,800,000

Fair Value - Schedule of Obliga

Fair Value - Schedule of Obligations for Each Relevant Transaction (Details) - USD ($)	Dec. 31, 2023	Dec. 31, 2022
Business Acquisition [Line Items]
Contingent Consideration Payable	$ 0	$ 322,385
Bayon | Successful completion of Phase 2
Business Acquisition [Line Items]
Contingent Consideration Payable	1,000,000
Bayon | Successful completion of Phase 3
Business Acquisition [Line Items]
Contingent Consideration Payable	4,000,000
Bayon | FDA approval
Business Acquisition [Line Items]
Contingent Consideration Payable	1,700,000
Panoptes | FDA approval
Business Acquisition [Line Items]
Contingent Consideration Payable	4,800,000
Panoptes | Beginning of Phase 3
Business Acquisition [Line Items]
Contingent Consideration Payable	4,800,000
Jade | FDA approval
Business Acquisition [Line Items]
Contingent Consideration Payable	$ 2,200,000

Fair Value - Narrative (Details

Fair Value - Narrative (Details) - USD ($)	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Increase (decrease) in contingent consideration	$ 1,992,399	$ 582,605
Payment of contingent consideration	495,000	0
Other assets or liabilities that are subject to fair value methodology and estimation	0	0
Changes in contingent consideration	1,500,000
Bayon
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair value of contingent consideration	2,400,000	1,100,000
Increase (decrease) in contingent consideration	1,700,000
Payment of contingent consideration	500,000
Panoptes
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair value of contingent consideration	2,000,000	1,700,000
Increase (decrease) in contingent consideration	200,000
Jade
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair value of contingent consideration	800,000	$ 700,000
Increase (decrease) in contingent consideration	$ 37,400

Fair Value - Estimate to Measur

Fair Value - Estimate to Measure Contingent Consideration Unobservable Level 3 (Details) - Discounted cash flow	Dec. 31, 2023	Dec. 31, 2022
Payment discount rate
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]
Fair value contingent consideration measurement input	0.131	0.147
Probability of Success for milestone | Bayon | Minimum
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]
Fair value contingent consideration measurement input	0.42	0.17
Probability of Success for milestone | Bayon | Maximum
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]
Fair value contingent consideration measurement input	0.71	0.67
Probability of Success for milestone | Panoptes | Minimum
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]
Fair value contingent consideration measurement input	0.30	0.17
Probability of Success for milestone | Panoptes | Maximum
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]
Fair value contingent consideration measurement input	0.33	0.36
Probability of Success for milestone | Jade
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]
Fair value contingent consideration measurement input	0.56	0.56

Fair Value - Estimate to Meas_2

Fair Value - Estimate to Measure Contingent Consideration Unobservable Level 3 In-process R&D (Details)	Aug. 31, 2023
Probability of success for next development phase | Relief from Royalty Method | KIO-101
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]
In-process R&D	0.17
Probability of success for next development phase | Relief from Royalty Method | KIO-201 | Minimum
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]
In-process R&D	17
Probability of success for next development phase | Relief from Royalty Method | KIO-201 | Maximum
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]
In-process R&D	46
Probability of success for next development phase | Multi-Period Excess Earnings Method | KIO-104 | Minimum
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]
In-process R&D	17
Probability of success for next development phase | Multi-Period Excess Earnings Method | KIO-104 | Maximum
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]
In-process R&D	36
Probability of success for next development phase | Multi-Period Excess Earnings Method | KIO-301 | Minimum
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]
In-process R&D	17
Probability of success for next development phase | Multi-Period Excess Earnings Method | KIO-301 | Maximum
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]
In-process R&D	67
Payment discount rate | Relief from Royalty Method | KIO-101
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]
In-process R&D	0.30
Payment discount rate | Relief from Royalty Method | KIO-201
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]
In-process R&D	0.30
Payment discount rate | Multi-Period Excess Earnings Method | KIO-104
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]
In-process R&D	0.25
Payment discount rate | Multi-Period Excess Earnings Method | KIO-301
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]
In-process R&D	0.25

Property and Equipment (Details

Property and Equipment (Details) - USD ($)	Dec. 31, 2023	Dec. 31, 2022
Property, Plant and Equipment [Line Items]
Total Property and Equipment, Gross	$ 14,353	$ 172,496
Less Accumulated Depreciation	6,289	117,319
Total Property and Equipment, Net	$ 8,065	55,177
Laboratory Equipment
Property, Plant and Equipment [Line Items]
Estimated Useful Life (Years)	3 years
Total Property and Equipment, Gross	$ 11,832	88,399
Office Equipment
Property, Plant and Equipment [Line Items]
Estimated Useful Life (Years)	3 years
Total Property and Equipment, Gross	$ 2,521	3,409
Office Furniture
Property, Plant and Equipment [Line Items]
Estimated Useful Life (Years)	5 years
Total Property and Equipment, Gross	$ 0	58,119
Leasehold Improvements
Property, Plant and Equipment [Line Items]
Estimated Useful Life (Years)	2 years
Total Property and Equipment, Gross	$ 0	$ 22,569

Property and Equipment - Additi

Property and Equipment - Additional Information (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Property, Plant and Equipment [Abstract]
Depreciation expense	$ 30	$ 17

Accrued Expenses (Details)

Accrued Expenses (Details) - USD ($)	Dec. 31, 2023	Dec. 31, 2022
Accrued Liabilities [Abstract]
Payroll and Benefits	$ 875,254	$ 1,312,443
Professional Fees	43,387	282,721
Clinical Trials	397,465	57,020
Other	64,560	183,750
Total Accrued Expenses	$ 1,380,666	$ 1,835,934

Intangible Assets and In-Proc_3

Intangible Assets and In-Process R&D - Additional Information (Details) - USD ($)	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Sep. 30, 2018	Sep. 26, 2018
Intangible Assets and In-Process R&D, Net	$ 8,813,850	$ 10,743,164
Amortization expense	$ 25,000	$ 25,000
SentrX Animal Care Inc
Intangible Assets and In-Process R&D, Net			$ 300,000
Intangible assets, expected milestone payments			$ 4,800,000	$ 4,750,000

Intangible Assets and In-Proc_4

Intangible Assets and In-Process R&D -Intangible assets and in-process R&D (Details) - USD ($)	Dec. 31, 2023	Dec. 31, 2022
Intangible Assets, Net	$ 118,750
Trade Secrets
Estimated Useful Life (Years)	10 years
Trade Secrets	$ 250,000	$ 250,000
Less: Accumulated Amortization	(131,250)	(106,250)
Intangible Assets, Net	118,750	143,750
In-Process R&D	8,695,100	10,599,414
Total Intangible Assets and In-Process R&D, Net	$ 8,813,850	$ 10,743,164

Intangible Assets and In-Proc_5

Intangible Assets and In-Process R&D - Future Annual Intangible Amortization (Details)	Dec. 31, 2023 USD ($)
Goodwill and Intangible Assets Disclosure [Abstract]
2024	$ 25,000
2025	25,000
2026	25,000
2027	25,000
2028	18,750
Intangible Assets, Net	$ 118,750

Capital Stock (Details)

Capital Stock (Details)

1 Months Ended

12 Months Ended

Aug. 07, 2023 USD ($) shares

Aug. 05, 2023 day $ / shares

Jun. 06, 2023 USD ($) $ / shares shares

Feb. 22, 2023 USD ($) shares

Feb. 10, 2023 USD ($) shares

Feb. 03, 2023 USD ($) $ / shares shares

Nov. 17, 2022 USD ($) $ / shares shares

Jul. 26, 2022 USD ($) $ / shares shares

Jun. 18, 2022 shares

Nov. 30, 2023 USD ($) shares

Aug. 31, 2023 shares

Jul. 31, 2023 shares

Jun. 30, 2023 shares

Apr. 30, 2023 USD ($) shares

Feb. 28, 2023 shares

Dec. 31, 2023 USD ($) shares

Dec. 31, 2022 USD ($) shares

Class of Stock [Line Items]

Net proceeds from sale | $

$ 5,600,000

Underwriting discount and commissions | $

500,000

Underwriting expenses | $

$ 200,000

Exercise price (in usd per share) | $ / shares

$ 8

Proceeds from warrant exercise and sale | $

$ 3,100,000

Placement agent transaction fees, equal to percentage of gross proceeds from sale

8%

Proceeds from exercise of warrants | $

$ 8,600

$ 307,079

$ 520,000

Proceeds from private placement, net of issuance costs | $

115,715

0

Warrants outstanding (in shares)

11,500,000

Deemed dividends from warrant reset provision | $

$ 500,000

$ 530,985

$ 0

Lincoln Park

Class of Stock [Line Items]

Proceeds from issuance of common stock, net of offering costs | $

$ 100,000

$ 300,000

Common Stock

Class of Stock [Line Items]

Issuance of Panoptes holdback shares (in shares)

10,087

Issuance of shares of common stock from warrant exercises (in shares)

66,400

65,000

Class A Warrant

Class of Stock [Line Items]

Warrants exercised (in shares)

654,609

Inducement Warrant

Class of Stock [Line Items]

Exercise price (in usd per share) | $ / shares

$ 5.97

Period from issuance that warrant becomes exercisable

6 months

Warrants and rights outstanding, term

18 months

Class C Warrant

Class of Stock [Line Items]

Issuance of shares of common stock from warrant exercises (in shares)

50,000

8,200

50,000

Proceeds from exercise of warrants | $

$ 300,000

Class D Warrants

Class of Stock [Line Items]

Issuance of shares of common stock from warrant exercises (in shares)

8,200

Public Offering

Class of Stock [Line Items]

Public offering price (in usd per share) | $ / shares

8

Shares issued, price per preferred share, five thousand Class A warrants and five thousand Class B warrants (in usd per share) | $ / shares

$ 1,000

Net proceeds from sale | $

$ 5,300,000

Underwriting discount and commissions | $

400,000

Underwriting expenses | $

$ 300,000

Proceeds from issuance of common stock, net of offering costs | $

$ 5,595,962

$ 5,377,719

Public Offering | Common Stock

Class of Stock [Line Items]

Issuance of Stock (in shares)

2,197,628

592,392

Public Offering | Class A Warrant

Class of Stock [Line Items]

Number of warrants issued to purchase the shares (in shares)

30,095,697

Number of warrants considered for determination of public offering price of preferred shares issued with warrants (in shares)

5,000

Public Offering | Class A Warrants, Exercise of Option

Class of Stock [Line Items]

Number of warrants issued to purchase the shares (in shares)

3,925,525

Public Offering | Class B Warrant

Class of Stock [Line Items]

Number of warrants issued to purchase the shares (in shares)

30,095,697

Number of warrants considered for determination of public offering price of preferred shares issued with warrants (in shares)

5,000

Public Offering | Class B Warrant, Exercise Of Option

Class of Stock [Line Items]

Number of warrants issued to purchase the shares (in shares)

3,925,525

Public Offering | Class C Warrant

Class of Stock [Line Items]

Number of warrants issued to purchase the shares (in shares)

5,750,000

Public Offering | Class D Warrants

Class of Stock [Line Items]

Number of warrants issued to purchase the shares (in shares)

5,750,000

Public Offering | Class C and Class D Warrants

Class of Stock [Line Items]

Exercise price (in usd per share) | $ / shares

$ 0.5231

$ 1.10

Warrants exercise price reduction, trading day period immediately following initial exercise day | day

60

Warrant exercise price reduction percentage of average of the volume weighted average price for trading day period immediately prior to reset date

90%

Warrants exercise price reduction, trading day period immediately prior to reset date | day

5

Private Placement

Class of Stock [Line Items]

Issuance of Stock (in shares)

52,798

Number of warrants issued to purchase the shares (in shares)

105,596

Warrants and rights outstanding, term

5 years

Proceeds from private placement, net of issuance costs | $

$ 100,000

Warrants exercisable, anniversary of closing date

6 months

Private Placement | Common Stock

Class of Stock [Line Items]

Exercise price (in usd per share) | $ / shares

$ 3.538

Private Placement | Common Stock

Class of Stock [Line Items]

Issuance of Stock (in shares)

52,798

Over-Allotment Option | Class C Warrants, Exercise Option

Class of Stock [Line Items]

Number of warrants issued to purchase the shares (in shares)

750,000

Over-Allotment Option | Class D Warrants, Exercise Option

Class of Stock [Line Items]

Number of warrants issued to purchase the shares (in shares)

750,000

Common Shares

Class of Stock [Line Items]

Number of warrants issued to purchase the shares (in shares)

98,138

Common Shares | Public Offering

Class of Stock [Line Items]

Issuance of Stock (in shares)

592,392

Number of warrants issued to purchase the shares (in shares)

160,000

Number of securities called by each warrant or right (in shares)

40

Warrants convertible into common stock (in shares)

1,504,785

Series E Convertible Preferred Stock | Public Offering

Class of Stock [Line Items]

Number of shares issued upon conversion (in shares)

1,280

Common Stock

Class of Stock [Line Items]

Number of shares issued upon conversion (in shares)

481,770

481,770

2,688,822

Common Stock | Lincoln Park

Class of Stock [Line Items]

Issuance of Stock (in shares)

20,000

105,000

Equity line of credit (up to) | $

$ 10,000,000

Common Stock | Inducement Warrant

Class of Stock [Line Items]

Number of warrants issued to purchase the shares (in shares)

654,609

Common Stock | Public Offering

Class of Stock [Line Items]

Issuance of Stock (in shares)

2,197,628

Number of warrants issued to purchase the shares (in shares)

3,552,372

Common Stock | Over-Allotment Option

Class of Stock [Line Items]

Number of warrants issued to purchase the shares (in shares)

750,000

Series F Convertible Preferred Stock

Class of Stock [Line Items]

Conversion of stock, shares converted (in shares)

530

530

2,958

Series F Convertible Preferred Stock | Public Offering

Class of Stock [Line Items]

Number of shares issued upon conversion (in shares)

3,908

Series F Convertible Preferred Stock | Public Offering | 909 Class C and 909 Class D Warrants

Class of Stock [Line Items]

Purchase price (in usd per share) | $ / shares

$ 999.90

Panoptes Pharma Ges .m.b.h.

Class of Stock [Line Items]

Issuance of Panoptes holdback shares (in shares)

10,087

Holdback shares, term

18 months

Warrants (Details)

Warrants (Details) - $ / shares	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Number of Awards
Non-vested Outstanding at beginning of year (in shares)	30,000
Non-vested Outstanding at end of year (in shares)	229,373	30,000
Common Stock Warrants
Number of Awards
Non-vested Outstanding at beginning of year (in shares)	1,597,606	168,932
Issued (in shares)	11,605,596	2,159,395
Exercised (in shares)	(66,400)	(719,609)
Expired (in shares)		(11,112)
Expired (in shares)	(72,503)
Non-vested Outstanding at end of year (in shares)	13,064,299	1,597,606	168,932
Weighted Average Exercise Price
Outstanding at beginning of year (in usd per share)	$ 21.22	$ 199.65
Issued (in usd per share)	0.55	7.38
Exercised (in usd per share)	5.97	5.06
Expired (in usd per share)	108.80	900
Outstanding at end of year (in usd per share)	$ 2.40	$ 21.22	$ 199.65
Weighted Average Remaining Term in Years
Outstanding	2 years 5 months 4 days	3 years 25 days	3 years 5 months 1 day
Issued	3 years 7 days	2 years 6 months 18 days

Equity Incentive Plan - Additio

Equity Incentive Plan - Additional Information (Details) - USD ($)	1 Months Ended	12 Months Ended
	Jan. 31, 2023	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2010	Sep. 30, 2023
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Maximum number of shares that may be issued (in shares)				59,414
Options granted (in shares)		764,400	78,641
Weighted average fair value of options granted (in usd per share)		$ 1.11	$ 27.08
Fair value of options granted		$ 600,000	$ 800,000
Unrecognized compensation expense		$ 700,000	$ 800,000
Unrecognized compensation expense, period for recognition		2 years 4 months 24 days	2 years 1 month 6 days
Aggregate intrinsic value of options outstanding		$ 0	$ 0
Aggregate intrinsic value of options exercisable		$ 0	$ 0
Share price (in usd per share)		$ 0.5220	$ 3.43
2014 Plan
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Common stock available for grant (in shares)		183,604
ESPP
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Total shares issuable (in shares)		284
Common stock available for grant (in shares)		191
Employee Stock Options
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Vesting period		4 years
Award service period		3 years
Employee Stock Options | Tranche One
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Vesting period		1 year
Vesting percentage		25%
Employee Stock Options | Tranche Two
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Vesting period		24 months
Employee Stock Options | 2014 Plan
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Maximum number of shares that may be issued (in shares)					1,000,000
Total shares issuable (in shares)		1,298,848
Number of shares of common stock issuable (in shares)	76,632
Employee Stock Options | 2014 Plan | Tranche One
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Vesting period		1 year
Vesting percentage		33%
Employee Stock Options | 2014 Plan | Tranche Two
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Vesting period		24 months
Restricted Stock
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Forfeited (in shares)		3,300	127
Issued (in shares)		270,050	30,000
Unrecognized compensation expense		$ 300,000	$ 200,000
Unrecognized compensation expense, period for recognition		2 years 3 months 18 days	2 years 9 months 18 days
Restricted Stock | Tranche One
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Vesting period		1 year
Vesting percentage		33%
Restricted Stock | Tranche Two
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Vesting period		24 months
Holders Owing More Than Ten Percentage Voting Rights
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Vesting period				5 years
Minimum | Holders Owing More Than Ten Percentage Voting Rights
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Percentage of exercise price				110%
Maximum | Holders Owing More Than Ten Percentage Voting Rights
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Vesting period				10 years

Equity Incentive Plan - Schedul

Equity Incentive Plan - Schedule of stock option activity (Details) - $ / shares	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Number of Options
Outstanding at beginning of year (in shares)	84,751	12,954
Granted (in shares)	764,400	78,641
Expired (in shares)	(927)	(14)
Forfeited (in shares)	(35,279)	(6,830)
Outstanding at end of year (in shares)	812,945	84,751	12,954
Exercisable at end of year (in shares)	173,394	4,939
Vested and expected to vest at end of year (in shares)	812,945	84,751
Weighted Average Exercise Price
Outstanding at beginning of year (in usd per share)	$ 36.92	$ 426.25
Granted (in usd per share)	1.11	8.49
Expired (in usd per share)	373.32	842.57
Forfeited (in usd per share)	5.08	446.34
Outstanding at end of year (in usd per share)	4.26	36.92	$ 426.25
Exercisable at end of year (in usd per share)	13.79	442.52
Vested and expected to vest at end of year (in usd per share)	$ 4.26	$ 36.92
Weighted Average Contractual Life
Outstanding	9 years 6 months 21 days	9 years 7 months 2 days	5 years 6 months 21 days
Exercisable at end of year	9 years 5 months 15 days	7 years 3 months 7 days
Vested and expected to vest at end of year	9 years 6 months 21 days	9 years 7 months 2 days

Equity Incentive Plan - Weighte

Equity Incentive Plan - Weighted-Average Assumptions (Details)	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Risk-Free Interest Rate, Minimum	3.95%
Risk-Free Interest Rate, Maximum	4.61%
Risk-Free Interest Rate		2.42%
Expected Life		5 years
Expected Average Volatility, Minimum	141%
Expected Average Volatility, Maximum	145.20%
Expected Average Volatility		140%
Expected Dividend Yield	0%	0%
Maximum
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Expected Life	5 years 7 months 6 days
Minimum
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Expected Life	5 years

Equity Incentive Plan - Restric

Equity Incentive Plan - Restricted Stock Activity (Details) - $ / shares	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Number of Shares
Non-vested Outstanding at beginning of year (in shares)	30,000
Non-vested Outstanding at end of year (in shares)	229,373	30,000
Restricted Stock
Number of Shares
Non-vested Outstanding at beginning of year (in shares)	30,000	375
Awarded (in shares)	270,050	30,000
Released (in shares)	(67,377)	(248)
Expired (in shares)	(3,300)	(127)
Non-vested Outstanding at end of year (in shares)	229,373	30,000	375
Weighted-Average Grant Date Fair Value
Non-vested Outstanding at beginning of year (in usd per share)	$ 6.78	$ 261.47
Awarded (in usd per share)	1.06	6.78
Released (in usd per share)	1.49	261.45
Forfeited (in usd per share)	3.83	261.51
Non-vested Outstanding at end of year (in usd per share)	$ 1.64	$ 6.78	$ 261.47
Weighted-Average Remaining Recognition Period
Non-vested Outstanding	2 years 6 months 25 days	2 years 9 months 14 days	1 year 1 month 2 days

Equity Incentive Plan - Stock-b

Equity Incentive Plan - Stock-based Compensation (Details) - USD ($)	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Total Stock-Based Compensation Expense	$ 754,944	$ 462,450
General and Administrative
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Total Stock-Based Compensation Expense	345,488	343,475
Research and Development
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Total Stock-Based Compensation Expense	$ 409,456	$ 118,975

Income Taxes -Components of los

Income Taxes -Components of loss before income taxes (Details) - USD ($)	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Income Tax Disclosure [Abstract]
Domestic	$ (9,384,178)	$ (10,563,302)
Foreign	(3,039,399)	(3,133,318)
Loss Before Income Tax (Expense) Benefit	$ (12,423,577)	$ (13,696,620)

Income Taxes - Components of in

Income Taxes - Components of income tax (benefit) expense (Details) - USD ($)	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Deferred Taxes:
Federal	$ (280,954)	$ 4,954
State	371,273	(117,964)
Total Deferred Taxes	90,319	(113,010)
Income Tax Expense (Benefit)	$ 90,319	$ (113,010)

Income Taxes - Reconciliation o

Income Taxes - Reconciliation of effective tax rate (Details)	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Income Tax Disclosure [Abstract]
United States Federal Income Tax Rate	21%	21%
State Taxes, Net of Federal Benefit	13.26%	(2.59%)
Non-deductible R&D Expenses	(3.49%)	0%
Contingent Consideration	(3.36%)	0%
GILTI Inclusion	(1.12%)	0%
Other Permanent Differences	(0.65%)	(9.24%)
Change in Valuation Allowance	(27.61%)	(9.53%)
Research and Development Credits	0.24%	0.58%
Tax Rate Differential	0.32%	2.89%
True Up Credit	(0.08%)	0%
Other	0.76%	(0.26%)
Effective Tax Rate Expense	(0.73%)	2.85%

Income Taxes - Deferred tax ass

Income Taxes - Deferred tax assets and liabilities (Details) - USD ($)	Dec. 31, 2023	Dec. 31, 2022
Net Deferred Tax Liability:
Net Operating Loss Carryforwards	$ 25,982,646	$ 22,809,667
Research and Development Credit Carryforwards	2,955,627	2,925,890
Capitalized Research and Development	4,743,068	4,606,902
Stock-Based Compensation	784,366	782,355
Cash Versus Accrual Adjustments	77,729	336,360
Total Deferred Tax Assets	34,543,436	31,461,174
Valuation Allowance	(33,025,829)	(29,593,286)
Net Deferred Tax Asset	1,517,607	1,867,888
Depreciation and Amortization	0	(477)
In-Process Research and Development	(2,297,047)	(2,556,532)
Net Deferred Tax Liability	$ (779,440)	$ (689,121)

Income Taxes - Additional Infor

Income Taxes - Additional Information (Details) - USD ($)	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2018	Dec. 31, 2017
Income Taxes
Net operating loss carryforwards	$ 90,200,000
Increase (decrease) in valuation allowance	3,400,000	$ 1,300,000
Unrecognized uncertain income tax	0	$ 0
Domestic Tax Authority
Income Taxes
Net operating loss carryforwards	600,000		$ 44,100,000	$ 46,100,000
Foreign Tax Authority
Income Taxes
Net operating loss carryforwards	12,200,000
State and Local Jurisdiction
Income Taxes
Net operating loss carryforwards	63,600,000
Tax credit carryforwards	500,000
Research Tax Credit Carryforward | Domestic Tax Authority
Income Taxes
Tax credit carryforwards	$ 2,500,000

Commitments and Contingencies -

Commitments and Contingencies - Additional Information (Details) € in Millions

1 Months Ended

12 Months Ended

Oct. 30, 2023 USD ($)

Sep. 07, 2023 USD ($)

May 01, 2020 USD ($)

Nov. 17, 2014 EUR (€)

Sep. 12, 2013 USD ($)

Jul. 02, 2013 EUR (€)

May 31, 2022

Dec. 31, 2023 USD ($) licenseAgreement operatingLease

Dec. 31, 2022 USD ($)

Oct. 15, 2023 ft²

Sep. 30, 2018 USD ($)

Sep. 26, 2018 USD ($)

Commitments and Contingencies [Line Items]

Number of operating leases | operatingLease

3

Cease payments not yet paid based on prevailing financial market conditions

8.50%

Operating lease expense

$ 200,000

$ 100,000

Number of license agreements | licenseAgreement

7

Payment of annual fee

$ 5,000

University of California

Commitments and Contingencies [Line Items]

Licensing agreement transfer, written notice period

15 days

Licensing agreement, successor written assignment agreement, notice period

30 days

Licensing agreement, assignment fee amount

$ 30,000

Licensing agreement, execution payment amount

$ 15,000

For The First 250 Million Net Sales

Commitments and Contingencies [Line Items]

Percentage of royalties on net sales

2%

Between 250 And 500 Million Net Sales

Commitments and Contingencies [Line Items]

Percentage of royalties on net sales

1.25%

Net Sales Over 500 Million

Commitments and Contingencies [Line Items]

Percentage of royalties on net sales

0.50%

SentrX Animal Care Inc

Commitments and Contingencies [Line Items]

Intangible assets, expected milestone payments

$ 4,800,000

$ 4,750,000

License

Commitments and Contingencies [Line Items]

Cost of sales

$ 30,000

€ 155

License | Licensing Agreements

Commitments and Contingencies [Line Items]

Percentage of royalties on net sales

6%

3.25%

KIO-101 | Mediolanum Agreement

Commitments and Contingencies [Line Items]

Percentage of royalties on net sales

7%

Contractual obligation | €

€ 20

Development and commercial milestones term

10 years

Percentage of decreased royalty after patent expiry

5%

Termination fee

$ 100,000

Termination fee payment

50,000

Termination fee payable

$ 50,000

Encinitas Lease

Commitments and Contingencies [Line Items]

Lessee term

18 months

Adelaide Lease

Commitments and Contingencies [Line Items]

Lessee term

12 months

Termination period

90 days

Vienna Lease

Commitments and Contingencies [Line Items]

Lessee term

5 years

Area of land | ft²

910

Commitments and Contingencies_2

Commitments and Contingencies - Maturities of Lease Liabilities (Details)	Dec. 31, 2023 USD ($)
Commitments and Contingencies Disclosure [Abstract]
2024	$ 53,966
2025	27,566
2026	14,366
2027	14,372
2028	11,373
Less: Amounts Representing Interest	(14,755)
Lease Liabilities	$ 106,890

Employee Benefit Plans (Details

Employee Benefit Plans (Details) - USD ($)	3 Months Ended	12 Months Ended
	Sep. 30, 2022	Dec. 31, 2023	Dec. 31, 2022
Postemployment Benefits [Abstract]
Matching contributions		0%
Company contributions	$ 29,200
Accrual of additional estimate of contributions			$ 8,500

Subsequent Events (Details)

Subsequent Events (Details)		1 Months Ended		3 Months Ended	12 Months Ended
	Feb. 05, 2024 USD ($) day $ / shares shares	Feb. 29, 2024 USD ($) $ / shares shares	Nov. 30, 2023 USD ($) shares	Mar. 25, 2024 USD ($)	Dec. 31, 2023 USD ($)	Dec. 31, 2022 USD ($)	Jan. 25, 2024 USD ($)	Jul. 26, 2022 $ / shares
Subsequent Event [Line Items]
Proceeds from private placement, net of issuance costs					$ 115,715	$ 0
Exercise price (in usd per share) | $ / shares								$ 8
Proceeds from warrant inducements					0	2,738,831
Proceeds from exercise of warrants			$ 8,600		$ 307,079	$ 520,000
Class D Warrants
Subsequent Event [Line Items]
Issuance of shares of common stock from warrant exercises (in shares) | shares			8,200
Subsequent event
Subsequent Event [Line Items]
Payment for sublicense fee				$ 700,000
Subsequent event | Théa Open Innovation
Subsequent Event [Line Items]
Milestone payment earned							$ 16,000,000
Maximum achievement milestone payment earned							$ 285,000,000
Percentage of royalties on net sales							20%
Subsequent event | Maxim Group LLC
Subsequent Event [Line Items]
Number of shares Issued in transaction | shares	15,800,000
Proceeds from private placement, net of issuance costs	$ 13,800,000
Subsequent event | Pre Funded Warrants | Maxim Group LLC
Subsequent Event [Line Items]
Number of warrants issued to purchase the shares (in shares) | shares	11,354,237
Subsequent event | Tranche A and tranche B warrants | Maxim Group LLC
Subsequent Event [Line Items]
Number of warrants issued to purchase the shares (in shares) | shares	49,374,590
Subsequent event | Tranche A warrants | Maxim Group LLC
Subsequent Event [Line Items]
Number of warrants issued to purchase the shares (in shares) | shares	24,687,295
Exercise price (in usd per share) | $ / shares	$ 0.6076
Proceeds from warrant inducements	$ 15,000,000
Volume weighted average price of common stock (in usd per share) | $ / shares	$ 1.1048
Number of threshold consecutive trading days | day	30
Warrants and rights outstanding, term	5 years
Subsequent event | Tranche B warrants | Maxim Group LLC
Subsequent Event [Line Items]
Number of warrants issued to purchase the shares (in shares) | shares	24,687,295
Exercise price (in usd per share) | $ / shares	$ 0.6076
Proceeds from warrant inducements	$ 15,000,000
Volume weighted average price of common stock (in usd per share) | $ / shares	$ 1.3810
Number of threshold consecutive trading days | day	30
Warrants and rights outstanding, term	5 years
Subsequent event | Class C warrants
Subsequent Event [Line Items]
Exercise price (in usd per share) | $ / shares		$ 0.5231
Issuance of shares of common stock from warrant exercises (in shares) | shares		914,155
Proceeds from exercise of warrants		$ 400,000
Subsequent event | Class D Warrants
Subsequent Event [Line Items]
Exercise price (in usd per share) | $ / shares		$ 0.5231
Issuance of shares of common stock from warrant exercises (in shares) | shares		1,836,402
Proceeds from exercise of warrants		$ 1,000,000