Exhibit 16.1
January 8, 2015
Securities and Exchange Commission
100 F Street, N.E.
Washington, DC 20549
Commissioners:
We have read the statements made by Zafgen, Inc. under the heading “Change in Accounting Firm Relationships”, in this registration statement on Form S-1 and we agree with the statements concerning our Firm under that heading.
Very truly yours,
/s/ Edelstein and Company LLP
Edelstein and Company LLP
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