Document and Entity Information
Document and Entity Information - shares | 6 Months Ended | |
Jun. 30, 2019 | Jul. 31, 2019 | |
Document And Entity Information [Abstract] | ||
Document Type | 10-Q | |
Amendment Flag | false | |
Document Period End Date | Jun. 30, 2019 | |
Document Fiscal Year Focus | 2019 | |
Document Fiscal Period Focus | Q2 | |
Trading Symbol | ZFGN | |
Entity Registrant Name | ZAFGEN, INC. | |
Entity Central Index Key | 0001374690 | |
Current Fiscal Year End Date | --12-31 | |
Entity Filer Category | Accelerated Filer | |
Entity Small Business | true | |
Entity Emerging Growth Company | true | |
Entity Ex Transition Period | true | |
Entity Common Stock, Shares Outstanding | 37,370,301 | |
Entity Current Reporting Status | Yes | |
Entity Shell Company | false | |
Entity File Number | 001-36510 | |
Entity Tax Identification Number | 203857670 | |
Entity Address, Address Line One | 3 Center Plaza | |
Entity Address, Address Line Two | Suite 610 | |
Entity Address, City or Town | Boston | |
Entity Address, State or Province | Massachusetts | |
Entity Address, Postal Zip Code | 02108 | |
City Area Code | 617 | |
Local Phone Number | 622-4003 |
Condensed Consolidated Balance
Condensed Consolidated Balance Sheets - USD ($) $ in Thousands | Jun. 30, 2019 | Dec. 31, 2018 |
Current assets: | ||
Cash and cash equivalents | $ 37,240 | $ 49,331 |
Marketable securities | 54,418 | 68,735 |
Tax incentive receivable | 1,532 | 1,536 |
Prepaid expenses and other current assets | 811 | 1,728 |
Total current assets | 94,001 | 121,330 |
Property and equipment, net | 968 | 375 |
Operating lease right-of-use assets | 7,342 | |
Tax incentive receivable, net of current portion | 214 | |
Restricted cash | 1,339 | |
Other assets | 20 | 57 |
Total assets | 103,884 | 121,762 |
Current liabilities: | ||
Accounts payable | 2,056 | 3,590 |
Accrued expenses | 3,516 | 4,261 |
Operating lease liabilities, current | 618 | |
Notes payable, current | 7,273 | 5,455 |
Total current liabilities | 13,463 | 13,306 |
Notes payable, long-term | 11,853 | 15,185 |
Operating lease liabilities | 6,429 | |
Total liabilities | 31,745 | 28,491 |
Commitments and contingencies (Note 7) | ||
Stockholders' equity: | ||
Preferred stock; $0.001 par value per share; 5,000,000 shares authorized as of June 30, 2019 and December 31, 2018; no shares issued and outstanding as of June 30, 2019 and December 31, 2018 | ||
Common stock, $0.001 par value per share; 115,000,000 shares authorized as of June 30, 2019 and December 31, 2018; 37,326,895 and 37,287,221 shares issued and outstanding as of June 30, 2019 and December 31, 2018, respectively | 37 | 37 |
Additional paid-in capital | 448,258 | 444,212 |
Accumulated deficit | (376,186) | (350,945) |
Accumulated other comprehensive income (loss) | 30 | (33) |
Total stockholders' equity | 72,139 | 93,271 |
Total liabilities and stockholders' equity | $ 103,884 | $ 121,762 |
Condensed Consolidated Balanc_2
Condensed Consolidated Balance Sheets (Parenthetical) - $ / shares | Jun. 30, 2019 | Dec. 31, 2018 |
Statement Of Financial Position [Abstract] | ||
Preferred stock, par value per share | $ 0.001 | $ 0.001 |
Preferred stock, shares authorized | 5,000,000 | 5,000,000 |
Preferred stock, shares issued | 0 | 0 |
Preferred stock, shares outstanding | 0 | 0 |
Common stock, par value per share | $ 0.001 | $ 0.001 |
Common stock, shares authorized | 115,000,000 | 115,000,000 |
Common stock, shares issued | 37,326,895 | 37,287,221 |
Common stock, shares outstanding | 37,326,895 | 37,287,221 |
Condensed Consolidated Statemen
Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended | ||
Jun. 30, 2019 | Jun. 30, 2018 | Jun. 30, 2019 | Jun. 30, 2018 | |
Income Statement [Abstract] | ||||
Revenue | $ 0 | $ 0 | $ 0 | $ 0 |
Operating expenses: | ||||
Research and development | 8,572 | 12,209 | 18,203 | 24,642 |
General and administrative | 3,618 | 3,351 | 7,264 | 6,620 |
Total operating expenses | 12,190 | 15,560 | 25,467 | 31,262 |
Loss from operations | (12,190) | (15,560) | (25,467) | (31,262) |
Other income (expense): | ||||
Interest income | 561 | 324 | 1,203 | 591 |
Interest expense | (478) | (466) | (978) | (924) |
Foreign currency transaction (losses) gains, net | (22) | (73) | 1 | (136) |
Total other income (expense), net | 61 | (215) | 226 | (469) |
Net loss | $ (12,129) | $ (15,775) | $ (25,241) | $ (31,731) |
Net loss per share, basic and diluted | $ (0.32) | $ (0.57) | $ (0.68) | $ (1.15) |
Weighted average common shares outstanding, basic and diluted | 37,326,853 | 27,565,064 | 37,320,436 | 27,553,394 |
Comprehensive loss: | ||||
Net loss | $ (12,129) | $ (15,775) | $ (25,241) | $ (31,731) |
Other comprehensive income: | ||||
Unrealized gain on marketable securities | 29 | 43 | 63 | 52 |
Total other comprehensive income | 29 | 43 | 63 | 52 |
Total comprehensive loss | $ (12,100) | $ (15,732) | $ (25,178) | $ (31,679) |
Condensed Consolidated Statem_2
Condensed Consolidated Statements of Changes in Stockholders' Equity - USD ($) $ in Thousands | Total | Common Stock [Member] | Additional Paid-in Capital [Member] | Accumulated Deficit [Member] | Accumulated Other Comprehensive Loss [Member] |
Beginning balance at Dec. 31, 2017 | $ 78,217 | $ 27 | $ 367,825 | $ (289,577) | $ (58) |
Beginning balance, shares at Dec. 31, 2017 | 27,489,457 | ||||
Issuance of common stock upon exercise of stock options and employee stock purchase plan | 261 | $ 1 | 260 | ||
Issuance of common stock upon exercise of stock options and employee stock purchase plan, shares | 63,893 | ||||
Issuance of restricted stock units, shares | 5,533 | ||||
Stock-based compensation expense | 2,466 | 2,466 | |||
Unrealized gain on marketable securities | 9 | 9 | |||
Net loss | (15,956) | (15,956) | |||
Ending balance at Mar. 31, 2018 | 64,997 | $ 28 | 370,551 | (305,533) | (49) |
Ending balance, shares at Mar. 31, 2018 | 27,558,883 | ||||
Beginning balance at Dec. 31, 2017 | 78,217 | $ 27 | 367,825 | (289,577) | (58) |
Beginning balance, shares at Dec. 31, 2017 | 27,489,457 | ||||
Net loss | (31,731) | ||||
Ending balance at Jun. 30, 2018 | 52,022 | $ 28 | 373,308 | (321,308) | (6) |
Ending balance, shares at Jun. 30, 2018 | 27,578,989 | ||||
Beginning balance at Mar. 31, 2018 | 64,997 | $ 28 | 370,551 | (305,533) | (49) |
Beginning balance, shares at Mar. 31, 2018 | 27,558,883 | ||||
Issuance of common stock upon exercise of stock options and employee stock purchase plan | 86 | 86 | |||
Issuance of common stock upon exercise of stock options and employee stock purchase plan, shares | 15,643 | ||||
Issuance of restricted stock units, shares | 4,463 | ||||
Stock-based compensation expense | 2,671 | 2,671 | |||
Unrealized gain on marketable securities | 43 | 43 | |||
Net loss | (15,775) | (15,775) | |||
Ending balance at Jun. 30, 2018 | 52,022 | $ 28 | 373,308 | (321,308) | (6) |
Ending balance, shares at Jun. 30, 2018 | 27,578,989 | ||||
Beginning balance at Dec. 31, 2018 | 93,271 | $ 37 | 444,212 | (350,945) | (33) |
Beginning balance, shares at Dec. 31, 2018 | 37,287,221 | ||||
Issuance of common stock upon exercise of stock options and employee stock purchase plan | 95 | 95 | |||
Issuance of common stock upon exercise of stock options and employee stock purchase plan, shares | 31,391 | ||||
Issuance of restricted stock units, shares | 4,467 | ||||
Stock-based compensation expense | 2,076 | 2,076 | |||
Unrealized gain on marketable securities | 34 | 34 | |||
Net loss | (13,112) | (13,112) | |||
Ending balance at Mar. 31, 2019 | 82,364 | $ 37 | 446,383 | (364,057) | 1 |
Ending balance, shares at Mar. 31, 2019 | 37,323,079 | ||||
Beginning balance at Dec. 31, 2018 | 93,271 | $ 37 | 444,212 | (350,945) | (33) |
Beginning balance, shares at Dec. 31, 2018 | 37,287,221 | ||||
Net loss | (25,241) | ||||
Ending balance at Jun. 30, 2019 | 72,139 | $ 37 | 448,258 | (376,186) | 30 |
Ending balance, shares at Jun. 30, 2019 | 37,326,895 | ||||
Beginning balance at Mar. 31, 2019 | 82,364 | $ 37 | 446,383 | (364,057) | 1 |
Beginning balance, shares at Mar. 31, 2019 | 37,323,079 | ||||
Issuance of restricted stock units, shares | 3,816 | ||||
Stock-based compensation expense | 1,875 | 1,875 | |||
Unrealized gain on marketable securities | 29 | 29 | |||
Net loss | (12,129) | (12,129) | |||
Ending balance at Jun. 30, 2019 | $ 72,139 | $ 37 | $ 448,258 | $ (376,186) | $ 30 |
Ending balance, shares at Jun. 30, 2019 | 37,326,895 |
Condensed Consolidated Statem_3
Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 6 Months Ended | |
Jun. 30, 2019 | Jun. 30, 2018 | |
Cash flows from operating activities: | ||
Net loss | $ (25,241) | $ (31,731) |
Adjustments to reconcile net loss to net cash used in operating activities | ||
Stock-based compensation expense | 3,951 | 5,137 |
Depreciation expense | 108 | 102 |
Unrealized foreign currency transaction losses | 5 | 74 |
Premium on marketable securities, net | (3) | |
Amortization of discount on marketable securities | (546) | (96) |
Changes in operating assets and liabilities: | ||
Prepaid expenses and other current assets | 917 | 638 |
Tax incentive receivable | (215) | (961) |
Accounts payable | (1,591) | (150) |
Accrued expenses and other | (672) | 413 |
Other assets | 37 | |
Net cash used in operating activities | (23,247) | (26,577) |
Cash flows from investing activities: | ||
Proceeds from sales and maturities of marketable securities | 76,069 | 62,193 |
Purchases of marketable securities | (61,143) | (35,871) |
Purchases of property and equipment | (409) | (20) |
Payments for leasehold improvements on right-of-use assets | (299) | |
Net cash provided by investing activities | 14,218 | 26,302 |
Cash flows from financing activities: | ||
Repayments of notes payable | (1,818) | |
Proceeds from exercise of common stock options and employee stock purchase plan | 95 | 347 |
Payment of public offering costs | (104) | |
Net cash (used in) provided by financing activities | (1,723) | 243 |
Net decrease in cash, cash equivalents and restricted cash | (10,752) | (32) |
Cash, cash equivalents and restricted cash at beginning of period | 49,331 | 40,777 |
Cash, cash equivalents and restricted cash at end of period | 38,579 | 40,745 |
Supplemental disclosure of non-cash investing and financing activities: | ||
Property and equipment included in accounts payable and accrued expenses | 292 | 26 |
Public offering costs included in accounts payable and accrued expenses and other | 196 | |
Supplemental disclosure of cash flow information: | ||
Cash paid for interest | $ 669 | $ 502 |
Nature of the Business and Basi
Nature of the Business and Basis of Presentation | 6 Months Ended |
Jun. 30, 2019 | |
Accounting Policies [Abstract] | |
Nature of the Business and Basis of Presentation | 1. Nature of the Business and Basis of Presentation Zafgen, Inc., or the Company, was incorporated on November 22, 2005 under the laws of the State of Delaware. in vivo in vitro in vivo Each of the Company’s product candidates is in the research and development stage. There can be no assurance that the Company’s research and development will be successfully completed, that adequate protection for the Company’s intellectual property will be obtained, that any product candidates developed will obtain necessary government regulatory approval or that any approved products will be commercially viable. Even if the Company’s product development efforts are successful, it is uncertain when, if ever, the Company will generate significant revenue from product sales. The Company operates in an environment of rapid change in technology and substantial competition from pharmaceutical and biotechnology companies. In addition, the Company is dependent upon the services of its employees and consultants. The Company has incurred losses and negative cash flows from operations since its inception. As of June 30, 2019, the Company had an accumulated deficit of $376.2 million. From its inception through June 30, 2019, the Company received net proceeds of $397.9 million from the sales of redeemable convertible preferred stock, the issuance of convertible promissory notes, the proceeds from its initial public offering (“IPO”) in June 2014 and its follow-on offerings in January 2015 and July 2018. On July 2, 2018, the Company completed a public offering of its common stock, which resulted in the sale of 9,200,000 shares at a price of $7.50 per share, resulting in net proceeds of approximately $64.6 million after deducting underwriting discounts and commissions, as well as offering costs. As disclosed in Note 5 to the condensed consolidated financial statements, the Company has a term loan with an aggregate principal balance of $18.2 million as of June 30, 2019. The loan agreement requires that the Company maintain certain minimum liquidity at all times, which as of June 30, 2019, was approximately $19.1 million. If the minimum liquidity covenant is not met, the Company may be required to repay the loan prior to scheduled maturity dates. Until such time, if ever, as the Company can generate substantial product revenue, the Company expects to finance its cash needs through a combination of equity offerings, debt financings, collaborations, strategic alliances, licensing arrangements and other sources of funding. Based on its current operating plans, the Company believes its cash, cash equivalents and marketable securities of $91.7 million as of June 30, 2019 will be sufficient to fund its anticipated level of operations, capital expenditures and satisfy debt repayments for a period of at least 12 months from the issuance date of this Quarterly Report. The Company expects to generate operating losses for the foreseeable future. If the Company is unable to raise additional funds through equity or debt financings, the Company may be required to delay, limit, reduce or terminate product development or future commercialization efforts or grant rights to develop and market products or product candidates that the Company would otherwise prefer to develop and market itself. The condensed consolidated financial statements include the accounts of the Company and its wholly owned subsidiaries Zafgen Securities Corporation, Zafgen Australia Pty Limited, and Zafgen Animal Health, LLC. All intercompany balances and transactions have been eliminated. Unaudited Interim Financial Information The condensed consolidated balance sheet as of December 31, 2018 was derived from the Company’s audited financial statements, but does not include all disclosures required by accounting principles generally accepted in the United States of America (“GAAP”). The accompanying unaudited condensed consolidated financial statements as of June 30, 2019 and for the three and six months ended June 30, 2019 and 2018, have been prepared by the Company, pursuant to the rules and regulations of the Securities and Exchange Commission (“SEC”), for interim financial statements. Certain information and footnote disclosures normally included in financial statements prepared in accordance with GAAP have been condensed or omitted pursuant to such rules and regulations. However, the Company believes that the disclosures are adequate to make the information presented not misleading. These condensed consolidated financial statements should be read in conjunction with the Company’s audited consolidated financial statements and the notes thereto for the year ended December 31, 2018, included in the Company’s Annual Report on Form 10-K, for the year ended December 31, 2018, on file with the SEC. In the opinion of management, all adjustments, consisting only of normal recurring adjustments necessary for a fair statement of the Company’s condensed consolidated financial position as of June 30, 2019 and condensed consolidated results of operations and cash flows for the three and six months ended June 30, 2019 and 2018 have been made. The results of operations for the three and six months ended June 30, 2019 are not necessarily indicative of the results of operations that may be expected for the year ending December 31, 2019. |
Summary of Significant Accounti
Summary of Significant Accounting Policies | 6 Months Ended |
Jun. 30, 2019 | |
Accounting Policies [Abstract] | |
Summary of Significant Accounting Policies | 2. Summary of Significant Accounting Policies Use of Estimates The preparation of financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities, the disclosure of contingent assets and liabilities as of the date of the condensed consolidated financial statements, and the reported amounts of expenses during the reporting periods. Significant estimates and assumptions reflected in these condensed consolidated financial statements include, but are not limited to, the accrual of research and development expenses and the valuation of stock-based awards. Estimates are periodically reviewed in light of changes in circumstances, facts and experience. Actual results could differ from the Company’s estimates. Marketable securities Marketable securities consist of investments with original maturities greater than ninety days. The Company has classified its investments with maturities beyond one year as short term, based on their highly liquid nature and because such marketable securities represent the investment of cash that is available for current operations. The Company classifies its marketable securities as available-for-sale. Accordingly, these investments are recorded at fair value, which is based on quoted market prices. Unrealized gains and losses are reported as a component of accumulated other comprehensive income (loss) in stockholders’ equity. Realized gains and losses and declines in value judged to be other than temporary are included as a component of other income (expense), net, based on the specific identification method. When determining whether a decline in value is other than temporary, the Company considers various factors, including whether the Company has the intent to sell the security, and whether it is more likely than not that the Company will be required to sell the security prior to recovery of its amortized cost basis. Fair value is determined based on quoted market prices. Net Loss Per Share Basic net loss per share is computed by dividing the net loss attributable to common stockholders by the weighted average number of common shares outstanding for the period. Diluted net loss per share attributable to common stockholders is computed by dividing the diluted net loss attributable to common stockholders by the weighted average number of common shares, including potential dilutive common shares assuming the dilutive effect of outstanding stock options and unvested restricted common shares, as determined using the treasury stock method. For periods in which the Company has reported net losses, diluted net loss per common share attributable to common stockholders is the same as basic net loss per common share attributable to common stockholders, since dilutive common shares are not assumed to have been issued if their effect is antidilutive. The Company excluded the following common stock equivalents, outstanding as of June 30, 2019 and 2018, from the computation of diluted net loss per share for the three and six months ended June 30, 2019 and 2018 because they had an anti-dilutive impact due to the net loss incurred for the periods: As of June 30, 2019 2018 Options to purchase common stock 6,717,144 6,261,528 Unvested restricted common stock 322,381 8,929 7,039,525 6,270,457 Recently Issued and Adopted Accounting Pronouncements In February 2016, the Financial Accounting Standards Board (the “FASB”) issued ASU No. 2016-02, Leases and in July 2018, the FASB issued ASU No. 2018-11, Leases (Topic 842): Targeted Improvements The new leasing standards generally require lessees to recognize operating and financing lease liabilities and corresponding right-of-use assets on the consolidated balance sheet and to provide enhanced disclosures surrounding the amount, timing and uncertainty of cash flows arising from leasing arrangements. We adopted the new leasing standards using the modified retrospective transition approach, as of January 1, 2019, with no restatement of prior periods or cumulative adjustment to retained earnings. Upon adoption, we elected the package of transition practical expedients, which allowed us to carry forward prior conclusions related to whether any expired or existing contracts are or contain leases, the lease classification for any expired or existing leases and initial direct costs for existing leases. In addition, the Company elected the hindsight practical expedient to determine the lease term for existing leases. The Company elected not to record leases with an initial term of 12 months or less on the balance sheet and recognize the associated lease payments in the consolidated statements of operations on a straight-line basis over the lease term. We determine if an arrangement is a lease at contract inception. Operating lease assets represent our right to use an underlying asset for the lease term and operating lease liabilities represent our obligation to make lease payments arising from the lease. Operating lease assets and liabilities are recognized at the commencement date of the lease based upon the present value of lease payments over the lease term. When determining the lease term, we include options to extend or terminate the lease when it is reasonably certain that we will exercise that option. We use the implicit rate when readily determinable and use our incremental borrowing rate when the implicit rate is not readily determinable based upon the information available at the commencement date in determining the present value of the lease payments. Our incremental borrowing rate is determined using a secured borrowing rate for the same currency and term as the associated lease. The lease payments used to determine our operating lease assets may include lease incentives, stated rent increases and escalation clauses linked to rates of inflation when determinable and are recognized in our operating lease assets in our condensed consolidated balance sheets. Our operating leases are reflected in operating lease right-of-use assets, accrued expenses and in long-term operating lease liabilities in our condensed consolidated balance sheets. Lease expense for minimum lease payments is recognized on a straight-line basis over the lease term. For additional information on the adoption of the new leasing standards, please read Note 7, Commitments and Contingencies In June 2018, the FASB issued ASU No. 2018-07, Compensation—Stock Compensation (Topic 718): Improvements to Nonemployee Share-Based Payment Accounting |
Fair Value Measurements and Mar
Fair Value Measurements and Marketable Securities | 6 Months Ended |
Jun. 30, 2019 | |
Fair Value Disclosures [Abstract] | |
Fair Value Measurements and Marketable Securities | 3. Fair Value Measurements and Marketable Securities Fair Value Measurements The following tables present information about the Company’s financial assets that have been measured at fair value as of June 30, 2019 and December 31, 2018 and indicate the fair value of the hierarchy of the valuation inputs utilized to determine such fair value. In general, fair values determined by Level 1 inputs utilize quoted prices (unadjusted) in active markets for identical assets or liabilities. Fair value determined by Level 2 inputs utilize observable inputs other than Level 1 prices, such as quoted prices, for similar assets or liabilities, quoted market prices in markets that are not active or other inputs that are observable or can be corroborated by observable market data for substantially the full term of the related assets or liabilities. Fair values determined by Level 3 inputs are unobservable data points for the asset or liability, and include situations where there is little, if any, market activity for the asset or liability. During the three and six months ended June 30, 2019 and the year ended December 31, 2018, there were no transfers between Level 1 and Level 2 financial assets. The following tables summarize the Company’s cash equivalents and marketable securities as of June 30, 2019 and December 31, 2018: June 30, 2019 Quoted Significant Prices in Other Significant Active Observable Unobservable Markets Inputs Inputs Total (Level 1) (Level 2) (Level 3) (in thousands) Cash equivalents: Money market funds $ 18,578 $ 18,578 $ — $ — Commercial paper 7,939 — 7,939 — Corporate bonds 3,381 — 3,381 — U.S. Government securities 1,897 — 1,897 — Total cash equivalents 31,795 18,578 13,217 — Marketable securities: Commercial paper 20,211 — 20,211 — U.S. Government securities 16,743 — 16,743 — Corporate bonds 17,464 — 17,464 — Total marketable securities 54,418 — 54,418 — Total cash equivalents and marketable securities $ 86,213 $ 18,578 $ 67,635 $ — December 31, 2018 Quoted Significant Prices in Other Significant Active Observable Unobservable Markets Inputs Inputs Total (Level 1) (Level 2) (Level 3) (in thousands) Cash equivalents: Money market funds $ 40,231 $ 40,231 $ — $ — Commercial paper 4,979 — 4,979 — Total cash equivalents 45,210 40,231 4,979 — Marketable securities: Commercial paper 38,911 — 38,911 — Corporate bonds 25,830 — 25,830 — U.S. Government securities 3,994 — 3,994 — Total marketable securities 68,735 — 68,735 — Total cash equivalents and marketable securities $ 113,945 $ 40,231 $ 73,714 $ — The carrying amounts reflected in the condensed consolidated balance sheets for tax incentive receivable, accounts payable, and accrued expenses and other approximate fair value due to their short-term maturities. The carrying value of the Company’s outstanding notes payable approximates fair value (a Level 2 fair value measurement), reflecting interest rates currently available to the Company. Marketable Securities The following tables summarize the Company’s marketable securities as of June 30, 2019 and December 31, 2018: June 30, 2019 Gross Gross Amortized Unrealized Unrealized Cost Gains Losses Fair Value (in thousands) Assets: Commercial paper (due within 1 year) $ 20,211 $ — $ — $ 20,211 Corporate bonds (due within 1 year) 15,930 20 (1 ) 15,949 Corporate bonds (due after 1 year) 1,507 8 — 1,515 U.S. Government securities (due within 1 year) 16,738 5 — 16,743 $ 54,386 $ 33 $ (1 ) $ 54,418 December 31, 2018 Gross Gross Amortized Unrealized Unrealized Cost Gains Losses Fair Value (in thousands) Assets: Commercial paper (due within 1 year) $ 38,921 $ — $ (10 ) $ 38,911 Corporate bonds (due within 1 year) 25,851 3 (24 ) 25,830 U.S. Government securities (due within 1 year) 3,995 — (1 ) 3,994 $ 68,767 $ 3 $ (35 ) $ 68,735 |
Accrued Expenses and Other
Accrued Expenses and Other | 6 Months Ended |
Jun. 30, 2019 | |
Payables And Accruals [Abstract] | |
Accrued Expenses and Other | 4. Accrued Expenses and Other Accrued expenses and other consisted of the following as of June 30, 2019 and December 31, 2018: June 30, December 31, 2019 2018 (in thousands) Accrued research and development expenses $ 1,346 $ 1,526 Accrued payroll and related expenses 1,343 2,291 Accrued professional fees 322 221 Accrued other 505 223 $ 3,516 $ 4,261 |
Notes Payable
Notes Payable | 6 Months Ended |
Jun. 30, 2019 | |
Debt Disclosure [Abstract] | |
Notes Payable | 5. Notes Payable On December 29, 2017, the Company entered into a loan and security agreement with Silicon Valley Bank (the “Term Loan”). The Term Loan provided for borrowings of $20.0 million. On December 29, 2017, the Company received proceeds of $20.0 million from the issuance of a promissory note. The promissory note issued under the Term Loan is collateralized by substantially all of the Company’s personal property, other than its intellectual property. Upon entering into the Term Loan, the Company became obligated to make monthly, interest-only payments until March 29, 2019 and, thereafter, to pay 33 consecutive, equal monthly installments of principal and interest from April 1, 2019 through December 1, 2021. The outstanding Term Loan bears a variable interest at an annual rate of 1.25% above the prime rate, which at June 30, 2019 was 5.5%. In addition, a final payment equal to 8.0% of the Term Loan is due upon the earlier of the maturity date, acceleration of the Term Loan or prepayment of all or part of the Term Loan. The Company accrues the final payment amount of $1.6 million, to outstanding debt by charges to interest expense using the effective-interest method from the date of issuance through the maturity date. Additionally, the Company, as borrower, is required to maintain a minimum cash, cash equivalents and marketable securities balance at Silicon Valley Bank of no less than 105% of the total outstanding principal balance of the Term Loan, which was $19.1 million and $21.0 million as of June 30, 2019 and December 31, 2018 , respectively Further, from 45 days after the Term Loan was entered in, the Company has met its obligation to maintain a balance of unrestricted cash, cash equivalents and marketable securities at Silicon Valley Bank in an amount not less than the greater of (i) $55.0 million and (ii) sixty-five percent (65%) of all the Company’s cash, cash equivalents and marketable securities. If the Company does not meet this requirement it will not be considered an event of default provided it immediately secures 87.5% of the principal balance in a restricted cash account. There are negative covenants restricting the Company’s activities, including limitations on dispositions, mergers or acquisitions; encumbering or granting a security interest in its intellectual property; incurring indebtedness or liens; paying dividends; making certain investments; limiting the aggregate value of cash maintained by its Australian subsidiary not to exceed $4.0 million and certain other business transactions. The Term Loan also includes events of default, the occurrence and continuation of any of which provides the lenders the right to exercise remedies against the Company and the collateral securing the amounts due under the Term Loan, including cash in the amount of the outstanding balance. These events of default include, among other things, failure to pay any amounts due under the Term Loan, insolvency, the occurrence of a material adverse event, the occurrence of any default under certain other indebtedness and a final judgment against the Company in an amount greater than $0.3 million. As of June 30, 2019 and December 31, 2018, notes payable consist of the following: June 30, December 31, 2019 2018 (in thousands) Notes payable $ 18,181 $ 20,000 Less: current portion (7,273 ) (5,455 ) Notes payable, net of current portion 10,908 14,545 Accretion related to final payment 945 640 Notes payable, long term $ 11,853 $ 15,185 As of June 30, 2019, the estimated future principal payments due are as follows: Year Ending December 31, (in thousands) 2019 (July - December) $ 3,636 2020 7,273 2021 7,272 Total $ 18,181 During the three and six months ended June 30, 2019, the Company recognized $0.5 million and $1.0 million, respectively, of interest expense related to the Term Loan. During the three and six months ended June 30, 2018, the Company recognized $0.5 million and $0.9 million, respectively, of interest expense related to the Term Loan. The effective annual interest rate as of June 30, 2019 on the outstanding debt under the Term Loan was approximately 9.9%. |
Stock-Based Awards
Stock-Based Awards | 6 Months Ended |
Jun. 30, 2019 | |
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract] | |
Stock-Based Awards | 6. Stock-Based Awards The Company’s 2014 Stock Option and Incentive Plan, as amended (the “2014 Plan”) provides for the grant of stock options, stock appreciation rights, restricted stock awards, restricted stock units, unrestricted stock awards, performance-share awards, cash-based awards and dividend equivalent rights to employees, members of the board of directors and consultants of the Company. The Company has outstanding stock-based awards under its Amended and Restated 2006 Stock Option Plan but is no longer granting awards under this plan. The Company also issues common stock under its 2014 Employee Stock Purchase Plan (the “ESPP”). As of June 30, 2019, 2,332,985 shares are available for grant under the 2014 Plan, including 1,491,488 shares automatically added to the 2014 Plan on January 1, 2019, and 109,120 shares are available for issuance to participating employees under the ESPP. The Company recorded stock-based compensation expense related to stock options, restricted common stock and the ESPP in the following expense categories within its condensed consolidated statements of operations for the three and six months ended June 30, 2019 and 2018 as follows: Three Months Ended June 30, Six Months Ended June 30, 2019 2018 2019 2018 (in thousands) Research and development $ 736 $ 1,664 $ 1,696 $ 3,236 General and administrative 1,139 1,007 2,255 1,901 $ 1,875 $ 2,671 $ 3,951 $ 5,137 |
Commitments and Contingencies
Commitments and Contingencies | 6 Months Ended |
Jun. 30, 2019 | |
Commitments And Contingencies Disclosure [Abstract] | |
Commitments and Contingencies | 7. Commitments and Contingencies Leases On February 12, 2019, the Company entered into a lease with Shigo Center Plaza Owners, LLC, for approximately 17,705 square feet of office space for a new headquarters located at 3 Center Plaza, Boston, Massachusetts. The lease has a term of 124 months with an option to extend the lease for 60 additional months. As part of the agreement the Company is required to maintain a letter of credit, which upon signing was $1.3 million and is classified as restricted cash within the condensed consolidated financial statements. Under the lease agreement, the Company will pay monthly rent beginning four months after June 21, 2019 with total lease payments over the initial term of $10.7 million. The Company also had a lease for office space in Boston, Massachusetts, effective as of July 28, 2014, with a term expiring July 31, 2020. On June 28, 2019, the Company amended the lease to terminate the lease effective as of June 30, 2019. In March 2015, the Company entered into an operating lease for additional office space in Boston, Massachusetts, effective as of April 15, 2015, with a term expiring on July 31, 2020, and an option to extend this lease for three additional years. In addition, with the landlord’s consent, the Company has subleased 2,976 square feet of office space in Boston, Massachusetts to an unrelated third party beginning on January 1, 2017 and expiring on June 30, 2020, and the Company expects to receive approximately $0.1 million in sublease rental income from July 1, 2019 through the end of the sublease term. In October 2015, the Company entered into an operating lease for office space in San Diego, California, effective as of October 1, 2015, with a term extended to expire on December 31, 2024. The future minimum lease payments for the next five years and thereafter as of June 30, 2019, are as follows: Year Ending December 31, Operating (in thousands) Leases 2019 (July - December) $ 508 2020 1,090 2021 1,120 2022 1,143 2023 1,165 Thereafter 6,585 Total lease payments 11,611 Less: imputed interest (4,564 ) Present value of lease liabilities $ 7,047 Under the prior lease guidance minimum rental commitments under non-cancelable leases for each of the next five years and thereafter as of December 31, 2018, were as follows: Year Ending December 31, Operating (in thousands) Leases 2019 $ 464 2020 226 2021 — 2022 — 2023 — Thereafter — Total lease payments $ 690 During the three months ended June 30, 2019 we incurred $0.1 million of lease expense associated with research and Three Months Six Months Ended June 30, Ended June 30, 2019 2019 (in thousands) (in thousands) Operating lease cost $ 120 $ 247 Short-term lease cost 72 113 Sublease income (28 ) (55 ) Total lease cost $ 164 $ 305 During the three months ended June 30, 2018 the Company recognized $0.1 million of rental expense related to office space. During the six months ended June 30, 2018 the Company recognized $0.2 million of rental expense related to office space. The following table summarizes the presentation in our condensed consolidated balance sheet information related to our operating leases: As of June 30, 2019 (in thousands) Assets Operating lease right-of-use assets $ 7,342 Liabilities Operating lease liabilities, short-term 618 Operating lease liabilities, long-term 6,429 Total operating lease liabilities $ 7,047 The weighted average remaining lease term and weighted average discount rate of our operating leases are as follows: As of June 30, 2019 Weighted average remaining lease term in years 9.97 Weighted average discount rate 11.1 % Supplemental cash flow information related to leases was as follow: Three Months Six Months Ended June 30, Ended June 30, 2019 2019 (in thousands) (in thousands) Cash paid for amounts included in the measurement of lease liabilities: Operating cash flows from operating leases $ 94 $ 188 Investing cash flows from operating leases 299 299 Right-of-use assets obtained in exchange for lease obligations: Operating leases 6,518 6,518 Intellectual Property Licenses The Company has acquired exclusive rights to develop patented compounds and related know-how for beloranib under two licensing agreements with two third parties in the course of its research and development activities. The licensing rights obligate the Company to make payments to the licensors for license fees, milestones, license maintenance fees and royalties. The Company is also responsible for patent prosecution costs. As of June 30, 2019, the Company is obligated to make additional milestone payments of up to $12.3 million upon reaching certain pre-commercialization milestones, such as clinical trials and government approvals (including the FDA, approval of a New Drug application (“NDA”), and up to $12.5 million upon reaching certain product commercialization milestones related to the development of beloranib. Under one of the license agreements, the Company is also obligated to pay up to $1.3 million with respect to each subsequent licensed product, if any, that is a new chemical entity. In addition, the Company will owe single-digit royalties on sales of commercial products developed using these licensed technologies, if any. There were no milestones achieved during the three and six months ended June 30, 2019 and 2018 and the development related to this technology is no longer active. The Company is also obligated to pay to the licensors a percentage of fees received if and when the Company sublicenses the technology. As of June 30, 2019, the Company has not yet developed a commercial product using the licensed technologies and it has not entered into any sublicense agreements for the technologies. Indemnification Agreements In the ordinary course of business, the Company may provide indemnification of varying scope and terms to vendors, lessors, business partners, and other parties with respect to certain matters including, but not limited to, losses arising out of breach of such agreements or from intellectual property infringement claims made by third parties. In addition, the Company has entered into indemnification agreements with members of its management team and its board of directors that will require the Company, among other things, to indemnify them against certain liabilities that may arise by reason of their status or service as directors or officers. The maximum potential amount of future payments the Company could be required to make under these indemnification agreements is, in many cases, unlimited. To date, the Company has not incurred any material costs as a result of such indemnifications. The Company does not believe that the outcome of any claims under indemnification arrangements will have a material effect on its financial position, results of operations or cash flows, and it has not accrued any liabilities related to such obligations in its condensed consolidated financial statements as of June 30, 2019. Legal Proceedings The Company accrues a liability for legal contingencies when it believes that it is both probable that a liability has been incurred and that the Company can reasonably estimate the amount of the loss. The Company reviews these accruals and adjusts them to reflect ongoing negotiations, settlements, rulings, advice of legal counsel and other relevant information. To the extent new information is obtained and the views on the probable outcomes of claims, suits, assessments, investigations or legal proceedings change, changes in the Company’s accrued liabilities would be recorded in the period in which such determination is made. In addition, in accordance with the relevant authoritative guidance, for any matters in which the likelihood of material loss is at least reasonably possible, the Company will provide disclosure of the possible loss or range of loss. If a reasonable estimate cannot be made, however, the Company will provide disclosure to that effect. The Company expenses legal costs as they are incurred. The Company may periodically become subject to other legal proceedings and claims arising in connection with ongoing business activities, including claims or disputes related to patents that have been issued or that are pending in the field of research on which the Company is focused. The Company is not aware of any material claims as of June 30, 2019. |
Retirement Plan
Retirement Plan | 6 Months Ended |
Jun. 30, 2019 | |
Compensation And Retirement Disclosure [Abstract] | |
Retirement Plan | 8. Retirement Plan Effective January 1, 2018, the Company adopted a 401(k) plan for its employees. Under the terms of the plan, the Company contributes 3% of an employee’s annual base salary, up to a maximum of the annual Internal Revenue Service compensation limits, for all full-time employees. During the three and six months ended June 30, 2019, the Company recognized $0.1 million of expense related to its contributions to the 401(k) plan. During the three and six months ended June 30, 2018 the Company recognized $0.1 million and $0.2 million, respectively, of expense related to its contributions to the 401(k) plan. |
Australia Research and Developm
Australia Research and Development Tax Incentive | 6 Months Ended |
Jun. 30, 2019 | |
Research And Development [Abstract] | |
Australia Research and Development Tax Incentive | 9. Australia Research and Development Tax Incentive The Company’s wholly owned subsidiary, Zafgen Australia Pty Limited, which conducts core research and development activities on behalf of the Company, is eligible to receive a 43.5% refundable tax incentive for qualified research and development activities through December 31, 2018 and 41% beginning January 1, 2019. For the three months ended June 30, 2019 and 2018, $0.1 million and $0.4 million, respectively, were recorded as a reduction to research and development expenses in the condensed consolidated statements of operations. For the six months ended June 30, 2019 and 2018, $0.2 million and $1.0 million, respectively, were recorded as a reduction to research and development expenses in the condensed consolidated statements of operations. These amounts represented 41% and 43.5%, respectively, of the Company’s qualified research and development spending in Australia. The refund is denominated in Australian dollars and, therefore, the related receivable is re-measured into U.S. dollars as of each reporting date. For the three months ended June 30, 2019 and 2018, the Company recorded in its condensed consolidated statements of operations unrealized foreign currency exchange losses of less than $0.1 million and $0.1 million, respectively, related to this tax incentive receivable. For the six months ended June 30, 2019 and 2018, the Company recorded in its condensed consolidated statements of operations unrealized foreign currency exchange losses of less than $0.1 million and $0.1 million, respectively, related to this tax incentive receivable. As of June 30, 2019 and December 31, 2018, the Company’s tax incentive receivable from the Australian government was $1.7 million and $1.5 million, respectively. |
Subsequent Events
Subsequent Events | 6 Months Ended |
Jun. 30, 2019 | |
Subsequent Events [Abstract] | |
Subsequent Events | 10. Subsequent Events On July 24, 2019, the Company implemented plans to reduce its operating expenses and prioritize key resources, with an immediate corporate restructuring as well as other strategies to preserve resources. This restructuring includes a workforce reduction of approximately 25%, in addition to other attrition in 2019. |
Summary of Significant Accoun_2
Summary of Significant Accounting Policies (Policies) | 6 Months Ended |
Jun. 30, 2019 | |
Accounting Policies [Abstract] | |
Unaudited Interim Financial Information | Unaudited Interim Financial Information The condensed consolidated balance sheet as of December 31, 2018 was derived from the Company’s audited financial statements, but does not include all disclosures required by accounting principles generally accepted in the United States of America (“GAAP”). The accompanying unaudited condensed consolidated financial statements as of June 30, 2019 and for the three and six months ended June 30, 2019 and 2018, have been prepared by the Company, pursuant to the rules and regulations of the Securities and Exchange Commission (“SEC”), for interim financial statements. Certain information and footnote disclosures normally included in financial statements prepared in accordance with GAAP have been condensed or omitted pursuant to such rules and regulations. However, the Company believes that the disclosures are adequate to make the information presented not misleading. These condensed consolidated financial statements should be read in conjunction with the Company’s audited consolidated financial statements and the notes thereto for the year ended December 31, 2018, included in the Company’s Annual Report on Form 10-K, for the year ended December 31, 2018, on file with the SEC. In the opinion of management, all adjustments, consisting only of normal recurring adjustments necessary for a fair statement of the Company’s condensed consolidated financial position as of June 30, 2019 and condensed consolidated results of operations and cash flows for the three and six months ended June 30, 2019 and 2018 have been made. The results of operations for the three and six months ended June 30, 2019 are not necessarily indicative of the results of operations that may be expected for the year ending December 31, 2019. |
Use of Estimates | Use of Estimates The preparation of financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities, the disclosure of contingent assets and liabilities as of the date of the condensed consolidated financial statements, and the reported amounts of expenses during the reporting periods. Significant estimates and assumptions reflected in these condensed consolidated financial statements include, but are not limited to, the accrual of research and development expenses and the valuation of stock-based awards. Estimates are periodically reviewed in light of changes in circumstances, facts and experience. Actual results could differ from the Company’s estimates. |
Marketable securities | Marketable securities Marketable securities consist of investments with original maturities greater than ninety days. The Company has classified its investments with maturities beyond one year as short term, based on their highly liquid nature and because such marketable securities represent the investment of cash that is available for current operations. The Company classifies its marketable securities as available-for-sale. Accordingly, these investments are recorded at fair value, which is based on quoted market prices. Unrealized gains and losses are reported as a component of accumulated other comprehensive income (loss) in stockholders’ equity. Realized gains and losses and declines in value judged to be other than temporary are included as a component of other income (expense), net, based on the specific identification method. When determining whether a decline in value is other than temporary, the Company considers various factors, including whether the Company has the intent to sell the security, and whether it is more likely than not that the Company will be required to sell the security prior to recovery of its amortized cost basis. Fair value is determined based on quoted market prices. |
Net Loss Per Share | Net Loss Per Share Basic net loss per share is computed by dividing the net loss attributable to common stockholders by the weighted average number of common shares outstanding for the period. Diluted net loss per share attributable to common stockholders is computed by dividing the diluted net loss attributable to common stockholders by the weighted average number of common shares, including potential dilutive common shares assuming the dilutive effect of outstanding stock options and unvested restricted common shares, as determined using the treasury stock method. For periods in which the Company has reported net losses, diluted net loss per common share attributable to common stockholders is the same as basic net loss per common share attributable to common stockholders, since dilutive common shares are not assumed to have been issued if their effect is antidilutive. The Company excluded the following common stock equivalents, outstanding as of June 30, 2019 and 2018, from the computation of diluted net loss per share for the three and six months ended June 30, 2019 and 2018 because they had an anti-dilutive impact due to the net loss incurred for the periods: As of June 30, 2019 2018 Options to purchase common stock 6,717,144 6,261,528 Unvested restricted common stock 322,381 8,929 7,039,525 6,270,457 |
Recently Issued and Adopted Accounting Pronouncements | Recently Issued and Adopted Accounting Pronouncements In February 2016, the Financial Accounting Standards Board (the “FASB”) issued ASU No. 2016-02, Leases and in July 2018, the FASB issued ASU No. 2018-11, Leases (Topic 842): Targeted Improvements The new leasing standards generally require lessees to recognize operating and financing lease liabilities and corresponding right-of-use assets on the consolidated balance sheet and to provide enhanced disclosures surrounding the amount, timing and uncertainty of cash flows arising from leasing arrangements. We adopted the new leasing standards using the modified retrospective transition approach, as of January 1, 2019, with no restatement of prior periods or cumulative adjustment to retained earnings. Upon adoption, we elected the package of transition practical expedients, which allowed us to carry forward prior conclusions related to whether any expired or existing contracts are or contain leases, the lease classification for any expired or existing leases and initial direct costs for existing leases. In addition, the Company elected the hindsight practical expedient to determine the lease term for existing leases. The Company elected not to record leases with an initial term of 12 months or less on the balance sheet and recognize the associated lease payments in the consolidated statements of operations on a straight-line basis over the lease term. We determine if an arrangement is a lease at contract inception. Operating lease assets represent our right to use an underlying asset for the lease term and operating lease liabilities represent our obligation to make lease payments arising from the lease. Operating lease assets and liabilities are recognized at the commencement date of the lease based upon the present value of lease payments over the lease term. When determining the lease term, we include options to extend or terminate the lease when it is reasonably certain that we will exercise that option. We use the implicit rate when readily determinable and use our incremental borrowing rate when the implicit rate is not readily determinable based upon the information available at the commencement date in determining the present value of the lease payments. Our incremental borrowing rate is determined using a secured borrowing rate for the same currency and term as the associated lease. The lease payments used to determine our operating lease assets may include lease incentives, stated rent increases and escalation clauses linked to rates of inflation when determinable and are recognized in our operating lease assets in our condensed consolidated balance sheets. Our operating leases are reflected in operating lease right-of-use assets, accrued expenses and in long-term operating lease liabilities in our condensed consolidated balance sheets. Lease expense for minimum lease payments is recognized on a straight-line basis over the lease term. For additional information on the adoption of the new leasing standards, please read Note 7, Commitments and Contingencies In June 2018, the FASB issued ASU No. 2018-07, Compensation—Stock Compensation (Topic 718): Improvements to Nonemployee Share-Based Payment Accounting |
Summary of Significant Accoun_3
Summary of Significant Accounting Policies (Tables) | 6 Months Ended |
Jun. 30, 2019 | |
Accounting Policies [Abstract] | |
Summary of Common Stock Equivalents Outstanding | The Company excluded the following common stock equivalents, outstanding as of June 30, 2019 and 2018, from the computation of diluted net loss per share for the three and six months ended June 30, 2019 and 2018 because they had an anti-dilutive impact due to the net loss incurred for the periods: As of June 30, 2019 2018 Options to purchase common stock 6,717,144 6,261,528 Unvested restricted common stock 322,381 8,929 7,039,525 6,270,457 |
Fair Value Measurements and M_2
Fair Value Measurements and Marketable Securities (Tables) | 6 Months Ended |
Jun. 30, 2019 | |
Fair Value Disclosures [Abstract] | |
Summary of Cash Equivalents and Marketable Securities | The following tables summarize the Company’s cash equivalents and marketable securities as of June 30, 2019 and December 31, 2018: June 30, 2019 Quoted Significant Prices in Other Significant Active Observable Unobservable Markets Inputs Inputs Total (Level 1) (Level 2) (Level 3) (in thousands) Cash equivalents: Money market funds $ 18,578 $ 18,578 $ — $ — Commercial paper 7,939 — 7,939 — Corporate bonds 3,381 — 3,381 — U.S. Government securities 1,897 — 1,897 — Total cash equivalents 31,795 18,578 13,217 — Marketable securities: Commercial paper 20,211 — 20,211 — U.S. Government securities 16,743 — 16,743 — Corporate bonds 17,464 — 17,464 — Total marketable securities 54,418 — 54,418 — Total cash equivalents and marketable securities $ 86,213 $ 18,578 $ 67,635 $ — December 31, 2018 Quoted Significant Prices in Other Significant Active Observable Unobservable Markets Inputs Inputs Total (Level 1) (Level 2) (Level 3) (in thousands) Cash equivalents: Money market funds $ 40,231 $ 40,231 $ — $ — Commercial paper 4,979 — 4,979 — Total cash equivalents 45,210 40,231 4,979 — Marketable securities: Commercial paper 38,911 — 38,911 — Corporate bonds 25,830 — 25,830 — U.S. Government securities 3,994 — 3,994 — Total marketable securities 68,735 — 68,735 — Total cash equivalents and marketable securities $ 113,945 $ 40,231 $ 73,714 $ — |
Summary of Marketable Securities | The following tables summarize the Company’s marketable securities as of June 30, 2019 and December 31, 2018: June 30, 2019 Gross Gross Amortized Unrealized Unrealized Cost Gains Losses Fair Value (in thousands) Assets: Commercial paper (due within 1 year) $ 20,211 $ — $ — $ 20,211 Corporate bonds (due within 1 year) 15,930 20 (1 ) 15,949 Corporate bonds (due after 1 year) 1,507 8 — 1,515 U.S. Government securities (due within 1 year) 16,738 5 — 16,743 $ 54,386 $ 33 $ (1 ) $ 54,418 December 31, 2018 Gross Gross Amortized Unrealized Unrealized Cost Gains Losses Fair Value (in thousands) Assets: Commercial paper (due within 1 year) $ 38,921 $ — $ (10 ) $ 38,911 Corporate bonds (due within 1 year) 25,851 3 (24 ) 25,830 U.S. Government securities (due within 1 year) 3,995 — (1 ) 3,994 $ 68,767 $ 3 $ (35 ) $ 68,735 |
Accrued Expenses and Other (Tab
Accrued Expenses and Other (Tables) | 6 Months Ended |
Jun. 30, 2019 | |
Payables And Accruals [Abstract] | |
Schedule of Accrued Expenses and Other | Accrued expenses and other consisted of the following as of June 30, 2019 and December 31, 2018: June 30, December 31, 2019 2018 (in thousands) Accrued research and development expenses $ 1,346 $ 1,526 Accrued payroll and related expenses 1,343 2,291 Accrued professional fees 322 221 Accrued other 505 223 $ 3,516 $ 4,261 |
Notes Payable (Tables)
Notes Payable (Tables) | 6 Months Ended |
Jun. 30, 2019 | |
Debt Disclosure [Abstract] | |
Schedule of Notes Payable | As of June 30, 2019 and December 31, 2018, notes payable consist of the following: June 30, December 31, 2019 2018 (in thousands) Notes payable $ 18,181 $ 20,000 Less: current portion (7,273 ) (5,455 ) Notes payable, net of current portion 10,908 14,545 Accretion related to final payment 945 640 Notes payable, long term $ 11,853 $ 15,185 |
Schedule of Estimated Future Principal Payments | As of June 30, 2019, the estimated future principal payments due are as follows: Year Ending December 31, (in thousands) 2019 (July - December) $ 3,636 2020 7,273 2021 7,272 Total $ 18,181 |
Stock-Based Awards (Tables)
Stock-Based Awards (Tables) | 6 Months Ended |
Jun. 30, 2019 | |
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract] | |
Summary of Stock-Based Compensation Expense Related to Stock Options, Restricted Common Stock and ESPP | The Company recorded stock-based compensation expense related to stock options, restricted common stock and the ESPP in the following expense categories within its condensed consolidated statements of operations for the three and six months ended June 30, 2019 and 2018 as follows: Three Months Ended June 30, Six Months Ended June 30, 2019 2018 2019 2018 (in thousands) Research and development $ 736 $ 1,664 $ 1,696 $ 3,236 General and administrative 1,139 1,007 2,255 1,901 $ 1,875 $ 2,671 $ 3,951 $ 5,137 |
Commitments and Contingencies (
Commitments and Contingencies (Tables) | 6 Months Ended |
Jun. 30, 2019 | |
Commitments And Contingencies Disclosure [Abstract] | |
Schedule of Future Minimum Lease Payments for Operating Leases | The future minimum lease payments for the next five years and thereafter as of June 30, 2019, are as follows: Year Ending December 31, Operating (in thousands) Leases 2019 (July - December) $ 508 2020 1,090 2021 1,120 2022 1,143 2023 1,165 Thereafter 6,585 Total lease payments 11,611 Less: imputed interest (4,564 ) Present value of lease liabilities $ 7,047 Under the prior lease guidance minimum rental commitments under non-cancelable leases for each of the next five years and thereafter as of December 31, 2018, were as follows: Year Ending December 31, Operating (in thousands) Leases 2019 $ 464 2020 226 2021 — 2022 — 2023 — Thereafter — Total lease payments $ 690 |
Schedule of Components of Leases Expense | The components of lease expense are as follows: Three Months Six Months Ended June 30, Ended June 30, 2019 2019 (in thousands) (in thousands) Operating lease cost $ 120 $ 247 Short-term lease cost 72 113 Sublease income (28 ) (55 ) Total lease cost $ 164 $ 305 |
Summary of Balance Sheet Information Related to Leases | The following table summarizes the presentation in our condensed consolidated balance sheet information related to our operating leases: As of June 30, 2019 (in thousands) Assets Operating lease right-of-use assets $ 7,342 Liabilities Operating lease liabilities, short-term 618 Operating lease liabilities, long-term 6,429 Total operating lease liabilities $ 7,047 |
Schedule of Weighted Average Remaining Lease Term and Weighted Average Discount Rate of Operating Leases | The weighted average remaining lease term and weighted average discount rate of our operating leases are as follows: As of June 30, 2019 Weighted average remaining lease term in years 9.97 Weighted average discount rate 11.1 % |
Schedule of Supplemental Cash Flow Information Related to Leases | Supplemental cash flow information related to leases was as follow: Three Months Six Months Ended June 30, Ended June 30, 2019 2019 (in thousands) (in thousands) Cash paid for amounts included in the measurement of lease liabilities: Operating cash flows from operating leases $ 94 $ 188 Investing cash flows from operating leases 299 299 Right-of-use assets obtained in exchange for lease obligations: Operating leases 6,518 6,518 |
Nature of the Business and Ba_2
Nature of the Business and Basis of Presentation - Additional Information (Detail) - USD ($) $ / shares in Units, $ in Thousands | Jul. 02, 2018 | Jun. 30, 2019 | Jun. 30, 2019 | Dec. 31, 2018 | Dec. 29, 2017 |
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] | |||||
Entity incorporation date | Nov. 22, 2005 | ||||
Accumulated deficit | $ 376,186 | $ 376,186 | $ 350,945 | ||
Net proceeds from sale of securities | 397,900 | ||||
Total cash, cash equivalents and marketable securities | 91,700 | 91,700 | |||
Term Loan [Member] | |||||
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] | |||||
Aggregate principal balance | 18,200 | 18,200 | $ 20,000 | ||
Loan agreement minimum liquidity required | $ 19,100 | $ 19,100 | $ 21,000 | ||
Public Offering [Member] | |||||
Organization Consolidation And Presentation Of Financial Statements Disclosure [Line Items] | |||||
Issuance of common stock | 9,200,000 | ||||
Share price per share | $ 7.50 | ||||
Net proceeds from public offering, after underwriting discount, commission and offering expenses | $ 64,600 |
Summary of Significant Accoun_4
Summary of Significant Accounting Policies - Summary of Common Stock Equivalents Outstanding (Detail) - shares | 6 Months Ended | |
Jun. 30, 2019 | Jun. 30, 2018 | |
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] | ||
Total potentially dilutive shares | 7,039,525 | 6,270,457 |
Options to Purchase Common Stock [Member] | ||
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] | ||
Total potentially dilutive shares | 6,717,144 | 6,261,528 |
Unvested Restricted Common Stock [Member] | ||
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] | ||
Total potentially dilutive shares | 322,381 | 8,929 |
Summary of Significant Accoun_5
Summary of Significant Accounting Policies - Additional Information (Detail) - USD ($) $ in Thousands | Jun. 30, 2019 | Jan. 01, 2019 |
New Accounting Pronouncements Or Change In Accounting Principle [Line Items] | ||
Operating lease right-of-use assets | $ 7,342 | |
Operating lease liabilities | $ 6,429 | |
ASU 2016-02 [Member] | ||
New Accounting Pronouncements Or Change In Accounting Principle [Line Items] | ||
Operating lease right-of-use assets | $ 1,000 | |
Operating lease liabilities | $ 1,000 |
Fair Value Measurements and M_3
Fair Value Measurements and Marketable Securities - Summary of Cash Equivalents and Marketable Securities (Detail) - USD ($) $ in Thousands | Jun. 30, 2019 | Dec. 31, 2018 |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Cash equivalents | $ 31,795 | $ 45,210 |
Marketable securities | 54,418 | 68,735 |
Total cash equivalents and marketable securities | 86,213 | 113,945 |
Money Market Funds [Member] | ||
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Cash equivalents | 18,578 | 40,231 |
Commercial Paper [Member] | ||
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Cash equivalents | 7,939 | 4,979 |
Marketable securities | 20,211 | 38,911 |
Corporate Bonds [Member] | ||
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Cash equivalents | 3,381 | |
Marketable securities | 17,464 | 25,830 |
U.S. Government Securities [Member] | ||
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Cash equivalents | 1,897 | |
Marketable securities | 16,743 | 3,994 |
Quoted Prices in Active Markets, (Level 1) [Member] | ||
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Cash equivalents | 18,578 | 40,231 |
Total cash equivalents and marketable securities | 18,578 | 40,231 |
Quoted Prices in Active Markets, (Level 1) [Member] | Money Market Funds [Member] | ||
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Cash equivalents | 18,578 | 40,231 |
Significant Other Observable Inputs (Level 2) [Member] | ||
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Cash equivalents | 13,217 | 4,979 |
Marketable securities | 54,418 | 68,735 |
Total cash equivalents and marketable securities | 67,635 | 73,714 |
Significant Other Observable Inputs (Level 2) [Member] | Commercial Paper [Member] | ||
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Cash equivalents | 7,939 | 4,979 |
Marketable securities | 20,211 | 38,911 |
Significant Other Observable Inputs (Level 2) [Member] | Corporate Bonds [Member] | ||
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Cash equivalents | 3,381 | |
Marketable securities | 17,464 | 25,830 |
Significant Other Observable Inputs (Level 2) [Member] | U.S. Government Securities [Member] | ||
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Cash equivalents | 1,897 | |
Marketable securities | $ 16,743 | $ 3,994 |
Fair Value Measurements and M_4
Fair Value Measurements and Marketable Securities - Summary of Marketable Securities (Detail) - USD ($) $ in Thousands | Jun. 30, 2019 | Dec. 31, 2018 |
Schedule of Available-for-sale Securities [Line Items] | ||
Amortized Cost | $ 54,386 | $ 68,767 |
Gross Unrealized Gains | 33 | 3 |
Gross Unrealized Losses | (1) | (35) |
Fair Value | 54,418 | 68,735 |
Commercial Paper (Due within 1 Year) [Member] | ||
Schedule of Available-for-sale Securities [Line Items] | ||
Amortized Cost | 20,211 | 38,921 |
Gross Unrealized Losses | (10) | |
Fair Value | 20,211 | 38,911 |
Corporate Bonds (Due within 1 Year) [Member] | ||
Schedule of Available-for-sale Securities [Line Items] | ||
Amortized Cost | 15,930 | 25,851 |
Gross Unrealized Gains | 20 | 3 |
Gross Unrealized Losses | (1) | (24) |
Fair Value | 15,949 | 25,830 |
Corporate Bonds (Due after 1 Year) [Member] | ||
Schedule of Available-for-sale Securities [Line Items] | ||
Amortized Cost | 1,507 | |
Gross Unrealized Gains | 8 | |
Fair Value | 1,515 | |
U.S. Government Securities (Due within 1 Year) [Member] | ||
Schedule of Available-for-sale Securities [Line Items] | ||
Amortized Cost | 16,738 | 3,995 |
Gross Unrealized Gains | 5 | |
Gross Unrealized Losses | (1) | |
Fair Value | $ 16,743 | $ 3,994 |
Accrued Expenses and Other - Sc
Accrued Expenses and Other - Schedule of Accrued Expenses and Other (Detail) - USD ($) $ in Thousands | Jun. 30, 2019 | Dec. 31, 2018 |
Payables And Accruals [Abstract] | ||
Accrued research and development expenses | $ 1,346 | $ 1,526 |
Accrued payroll and related expenses | 1,343 | 2,291 |
Accrued professional fees | 322 | 221 |
Accrued other | 505 | 223 |
Total accrued expenses and other | $ 3,516 | $ 4,261 |
Notes Payable - Additional Info
Notes Payable - Additional Information (Detail) - USD ($) | Dec. 29, 2017 | Jun. 30, 2019 | Jun. 30, 2018 | Jun. 30, 2019 | Jun. 30, 2018 | Dec. 31, 2018 |
Debt Instrument [Line Items] | ||||||
Proceeds from issuance of notes payable | $ 20,000,000 | |||||
Unrestricted cash, cash equivalents and marketable securities | $ 91,700,000 | $ 91,700,000 | ||||
Credit facility default amount | 300,000 | 300,000 | ||||
Maximum [Member] | ||||||
Debt Instrument [Line Items] | ||||||
Aggregate value of cash maintained by Australian subsidiary, limit | 4,000,000 | |||||
Term Loan [Member] | ||||||
Debt Instrument [Line Items] | ||||||
Maximum borrowings under term loan | $ 20,000,000 | $ 18,200,000 | $ 18,200,000 | |||
Debt facility description | Upon entering into the Term Loan, the Company became obligated to make monthly, interest-only payments until March 29, 2019 and, thereafter, to pay 33 consecutive, equal monthly installments of principal and interest from April 1, 2019 through December 1, 2021. The outstanding Term Loan bears a variable interest at an annual rate of 1.25% above the prime rate, which at June 30, 2019 was 5.5%. In addition, a final payment equal to 8.0% of the Term Loan is due upon the earlier of the maturity date, acceleration of the Term Loan or prepayment of all or part of the Term Loan. | |||||
Debt maturity date | Dec. 1, 2021 | |||||
Debt facility interest rate description | 1.25% above the prime rate | |||||
Debt facility variable interest at annual rate | 1.25% | |||||
Debt facility effective interest rate | 5.50% | 5.50% | ||||
Debt facility fee percentage | 8.00% | |||||
Charges to interest expense of debt outstanding | $ 1,600,000 | |||||
Loan agreement minimum liquidity required | $ 19,100,000 | $ 19,100,000 | $ 21,000,000 | |||
Debt facility covenant description | Further, from 45 days after the Term Loan was entered in, the Company has met its obligation to maintain a balance of unrestricted cash, cash equivalents and marketable securities at Silicon Valley Bank in an amount not less than the greater of (i) $55.0 million and (ii) sixty-five percent (65%) of all the Company’s cash, cash equivalents and marketable securities. If the Company does not meet this requirement it will not be considered an event of default provided it immediately secures 87.5% of the principal balance in a restricted cash account. | |||||
Percentage of principal balance to be secured in restricted cash account for not to be considered an event of default | 87.50% | |||||
Interest expense on term loan | 500,000 | $ 500,000 | $ 1,000,000 | $ 900,000 | ||
Debt facility effective interest rate | 9.90% | |||||
Term Loan [Member] | Minimum [Member] | ||||||
Debt Instrument [Line Items] | ||||||
Percentage equivalent of cash, cash equivalents and marketable securities balance | 105.00% | |||||
Unrestricted cash, cash equivalents and marketable securities | $ 55,000,000 | $ 55,000,000 | ||||
Percentage of cash, cash equivalents and marketable securities | 65.00% | 65.00% |
Notes Payable - Schedule of Not
Notes Payable - Schedule of Notes Payable (Detail) - USD ($) $ in Thousands | Jun. 30, 2019 | Dec. 31, 2018 |
Debt Instruments [Abstract] | ||
Notes payable | $ 18,181 | $ 20,000 |
Less: current portion | (7,273) | (5,455) |
Notes payable, net of current portion | 10,908 | 14,545 |
Accretion related to final payment | 945 | 640 |
Notes payable, long term | $ 11,853 | $ 15,185 |
Notes Payable - Schedule of Est
Notes Payable - Schedule of Estimated Future Principal Payments (Detail) $ in Thousands | Jun. 30, 2019USD ($) |
Debt Instruments [Abstract] | |
2019 (July - December) | $ 3,636 |
2020 | 7,273 |
2021 | 7,272 |
Total | $ 18,181 |
Stock-Based Awards - Additional
Stock-Based Awards - Additional Information (Detail) - shares | Jan. 01, 2019 | Jun. 30, 2019 |
2014 Stock Option and Incentive Plan [Member] | ||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | ||
Common stock available for issuance | 2,332,985 | |
Shares added to plan | 1,491,488 | |
2014 Employee Stock Purchase Plan [Member] | ||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | ||
Common stock available for issuance | 109,120 |
Stock-Based Awards - Summary of
Stock-Based Awards - Summary of Stock-Based Compensation Expense Related to Stock Options, Restricted Common Stock and ESPP (Detail) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended | ||
Jun. 30, 2019 | Jun. 30, 2018 | Jun. 30, 2019 | Jun. 30, 2018 | |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | ||||
Total stock-based compensation expense | $ 1,875 | $ 2,671 | $ 3,951 | $ 5,137 |
Research and Development [Member] | ||||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | ||||
Total stock-based compensation expense | 736 | 1,664 | 1,696 | 3,236 |
General and Administrative [Member] | ||||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | ||||
Total stock-based compensation expense | $ 1,139 | $ 1,007 | $ 2,255 | $ 1,901 |
Commitments and Contingencies -
Commitments and Contingencies - Additional Information (Detail) | Jun. 28, 2019 | Feb. 12, 2019USD ($)ft² | Jan. 01, 2017ft² | Oct. 01, 2015 | Apr. 15, 2015Option | Jul. 28, 2014 | Jun. 30, 2019USD ($) | Jun. 30, 2018USD ($) | Jun. 30, 2019USD ($) | Jun. 30, 2018USD ($) | Jun. 30, 2020USD ($) |
Other Commitments [Line Items] | |||||||||||
Total lease payments over the initial term | $ 11,611,000 | $ 11,611,000 | |||||||||
Sublease rental income | 28,000 | 55,000 | |||||||||
Lease expense | 164,000 | 305,000 | |||||||||
Operating lease, rental expense | $ 100,000 | $ 200,000 | |||||||||
Subsequent Licensed Product [Member] | |||||||||||
Other Commitments [Line Items] | |||||||||||
Licensing fees per product maximum | 1,300,000 | 1,300,000 | |||||||||
Development Based Milestones [Member] | |||||||||||
Other Commitments [Line Items] | |||||||||||
Milestone payments due | 0 | $ 0 | 0 | $ 0 | |||||||
Maximum [Member] | Pre Commercialization Milestones [Member] | |||||||||||
Other Commitments [Line Items] | |||||||||||
Milestone payments | 12,300,000 | 12,300,000 | |||||||||
Maximum [Member] | Product Commercialization Milestones [Member] | |||||||||||
Other Commitments [Line Items] | |||||||||||
Milestone payments | 12,500,000 | 12,500,000 | |||||||||
Research and Development [Member] | |||||||||||
Other Commitments [Line Items] | |||||||||||
Lease expense | 100,000 | 200,000 | |||||||||
General and Administrative [Member] | |||||||||||
Other Commitments [Line Items] | |||||||||||
Lease expense | $ 100,000 | ||||||||||
General and Administrative [Member] | Maximum [Member] | |||||||||||
Other Commitments [Line Items] | |||||||||||
Lease expense | $ 100,000 | ||||||||||
Boston Office Space [Member] | |||||||||||
Other Commitments [Line Items] | |||||||||||
Lease expiration date | Jul. 31, 2020 | ||||||||||
Amendement of lease, effective date of termination | Jun. 30, 2019 | ||||||||||
Boston Office Space [Member] | Unrelated Third Party [Member] | |||||||||||
Other Commitments [Line Items] | |||||||||||
Subleased area | ft² | 2,976 | ||||||||||
Sublease expiration date | Jun. 30, 2020 | ||||||||||
Boston Office Space [Member] | Unrelated Third Party [Member] | Scenario Forecast [Member] | |||||||||||
Other Commitments [Line Items] | |||||||||||
Sublease rental income | $ 100,000 | ||||||||||
Additional Boston Office Space [Member] | |||||||||||
Other Commitments [Line Items] | |||||||||||
Lease extension period | 3 years | ||||||||||
Operating lease, existence of option to extend | true | ||||||||||
Lease expiration date | Jul. 31, 2020 | ||||||||||
Number of options to extend lease | Option | 1 | ||||||||||
San Diego Office Space [Member] | |||||||||||
Other Commitments [Line Items] | |||||||||||
Lease expiration date | Dec. 31, 2024 | ||||||||||
Center Plaza, Boston [Member] | Massachusetts [Member] | Shigo Center Plaza Owners LLC [Member] | |||||||||||
Other Commitments [Line Items] | |||||||||||
Area of office space | ft² | 17,705 | ||||||||||
Operating lease term | 124 months | ||||||||||
Lease extension period | 60 months | ||||||||||
Letter of credit | $ 1,300,000 | ||||||||||
Operating lease, existence of option to extend | true | ||||||||||
Total lease payments over the initial term | $ 10,700,000 |
Commitments and Contingencies_2
Commitments and Contingencies - Schedule of Future Minimum Lease Payments for Operating Leases (Detail) $ in Thousands | Jun. 30, 2019USD ($) |
Leases [Abstract] | |
2019 (July - December) | $ 508 |
2020 | 1,090 |
2021 | 1,120 |
2022 | 1,143 |
2023 | 1,165 |
Thereafter | 6,585 |
Total lease payments | 11,611 |
Less: imputed interest | (4,564) |
Present value of lease liabilities | $ 7,047 |
Commitments and Contingencies_3
Commitments and Contingencies - Schedule of Future Minimum Rental Commitments under Prior Lease Guidance (Detail) $ in Thousands | Dec. 31, 2018USD ($) |
Commitments And Contingencies Disclosure [Abstract] | |
2019 | $ 464 |
2020 | 226 |
Total lease payments | $ 690 |
Commitments and Contingencies_4
Commitments and Contingencies - Schedule of Components of Leases Expense (Detail) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended |
Jun. 30, 2019 | Jun. 30, 2019 | |
Leases [Abstract] | ||
Operating lease cost | $ 120 | $ 247 |
Short-term lease cost | 72 | 113 |
Sublease income | (28) | (55) |
Total lease cost | $ 164 | $ 305 |
Commitments and Contingencies_5
Commitments and Contingencies - Summary of Balance Sheet Information Related to Leases (Detail) $ in Thousands | Jun. 30, 2019USD ($) |
Assets | |
Operating lease right-of-use assets | $ 7,342 |
Liabilities | |
Operating lease liabilities, short-term | 618 |
Operating lease liabilities | 6,429 |
Total operating lease liabilities | $ 7,047 |
Commitments and Contingencies_6
Commitments and Contingencies - Schedule of Weighted Average Remaining Lease Term and Weighted Average Discount Rate of Operating Leases (Detail) | Jun. 30, 2019 |
Leases [Abstract] | |
Weighted average remaining lease term in years | 9 years 11 months 19 days |
Weighted average discount rate | 11.10% |
Commitments and Contingencies_7
Commitments and Contingencies - Schedule of Supplemental Cash Flow Information Related to Leases (Detail) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended |
Jun. 30, 2019 | Jun. 30, 2019 | |
Cash paid for amounts included in the measurement of lease liabilities: | ||
Operating cash flows from operating leases | $ 94 | $ 188 |
Investing cash flows from operating leases | 299 | 299 |
Right-of-use assets obtained in exchange for lease obligations: | ||
Operating leases | $ 6,518 | $ 6,518 |
Retirement Plan - Additional In
Retirement Plan - Additional Information (Detail) - USD ($) $ in Millions | 3 Months Ended | 6 Months Ended | ||
Jun. 30, 2019 | Jun. 30, 2018 | Jun. 30, 2019 | Jun. 30, 2018 | |
Defined Contribution Plan Disclosure [Line Items] | ||||
Percentage of employer's contribution on employee's base salary | 3.00% | |||
Retirement 401K Plan [Member] | ||||
Defined Contribution Plan Disclosure [Line Items] | ||||
Contribution expense | $ 0.1 | $ 0.1 | $ 0.1 | $ 0.2 |
Australia Research and Develo_2
Australia Research and Development Tax Incentive - Additional Information (Detail) - USD ($) | Jan. 01, 2019 | Jun. 30, 2019 | Jun. 30, 2018 | Jun. 30, 2019 | Jun. 30, 2018 | Dec. 31, 2018 |
Research and Development Tax Incentive [Line Items] | ||||||
Unrealized foreign currency exchange losses | $ 5,000 | $ 74,000 | ||||
Zafgen Australia Pty Limited [Member] | ||||||
Research and Development Tax Incentive [Line Items] | ||||||
Unrealized foreign currency exchange losses | $ 100,000 | 100,000 | ||||
Zafgen Australia Pty Limited [Member] | Australia [Member] | ||||||
Research and Development Tax Incentive [Line Items] | ||||||
Tax incentive receivable | $ 1,700,000 | 1,700,000 | $ 1,500,000 | |||
Zafgen Australia Pty Limited [Member] | Maximum [Member] | ||||||
Research and Development Tax Incentive [Line Items] | ||||||
Unrealized foreign currency exchange losses | 100,000 | 100,000 | ||||
Research and Development [Member] | Zafgen Australia Pty Limited [Member] | ||||||
Research and Development Tax Incentive [Line Items] | ||||||
Percentage of refundable tax incentive | 41.00% | 43.50% | ||||
Reduction to research and development expenses | $ 100,000 | $ 400,000 | $ 200,000 | $ 1,000,000 | ||
Percentage of reduction in research and development costs | 41.00% | 43.50% |
Subsequent Events - Additional
Subsequent Events - Additional Information (Detail) | Jul. 24, 2019 |
Subsequent Event [Member] | |
Subsequent Event [Line Items] | |
Restructuring percentage of workforce reduction | 25.00% |