August 8, 2016
Via EDGAR Submission
Securities and Exchange Commission
Division of Corporation Finance
100 F Street N.E.
Washington, DC 20549-7010
| Re: | Protagonist Therapeutics, Inc. |
| Registration Statement on Form S-1 |
| Filed July 11, 2016 |
| File No. 333- 212476 |
Dear Ladies and Gentlemen:
In accordance with Rule 461 under the Securities Act of 1933, as amended (the “Act”), we, as the representative of the several underwriters, hereby join in the request of Protagonist Therapeutics, Inc. (the “Company”) for acceleration of the effective date of the above-named Registration Statement so that it becomes effective at 4:30 p.m. Eastern Time on August 10, 2016, or as soon thereafter as practicable.
Pursuant to Rule 460 under the Act, we, as the representatives of the several underwriters, wish to advise you that we have effected the following distribution of the Company’s Preliminary Prospectus dated August 1, 2016:
| (i) | Dates of distribution: August 1, 2016 through the date hereof |
| (ii) | Number of prospective underwriters to which the preliminary prospectus was furnished: 3 |
| (iii) | Number of prospectuses furnished to investors: approximately 520 |
| (iv) | Number of prospectuses distributed to others, including the Company, the Company’s counsel, independent accountants, and underwriters’ counsel: approximately 300 |
We, the undersigned, as the representative of the several underwriters, have complied and will comply, and we have been informed by the participating underwriters that they have complied and will comply, with the requirements of Rule 15c2-8 under the Securities Exchange Act of 1934.
(signature page follows)
| Very truly yours, | ||
| LEERINK PARTNERS LLC | ||
| As representative of the several underwriters | ||
| LEERINK PARTNERS LLC | ||
By: | /s/ Bryan Giraudo | |
Name: | Bryan Giraudo | |
Title: | Managing Director | |
BARCLAYS CAPITAL INC. | ||
As representative of the several underwriters | ||
| BARCLAYS CAPITAL INC. | ||
| By: | /s/ Victoria Hale | |
| Name: | Victoria Hale | |
| Title: | Vice President | |
(Signature Page to Acceleration Request Letter)
