![Graphic](https://capedge.com/proxy/DEFA14A/0001558370-22-014511/tmb-20220921xdefa14a001.jpg)
**** IMPORTANT REMINDER ****
Dear Aytu BioPharma, Inc. Stockholder:
By now, you should have received your proxy material for the Aytu BioPharma, Inc. Special Meeting which is scheduled to be held on October 5, 2022. You are receiving this reminder letter because your votes were not yet processed at the time that this letter was mailed. If you have already voted, we would like to thank you for your vote.
****PLEASE VOTE TODAY****
Your Board recommends that you vote FOR proposals 1, and 2. Even if you plan on attending the meeting, we urge you to vote your shares now, so they can be tabulated prior to the meeting.
Your vote is extremely important. PLEASE CAST YOUR VOTE TODAY. The fastest and easiest way to vote is by telephone or over the Internet. Instructions on how to vote your shares over the telephone or Internet are enclosed with this letter. Alternatively, you may sign and return the enclosed voting form in the envelope provided.
If you sign and return the enclosed voting form without indicating a different choice your shares will be voted as recommended by your Board of Directors.
WE URGE YOU TO EXERCISE YOUR RIGHT TO VOTE TODAY.
If you have questions or need help voting your shares, please call our proxy solicitation firm, Morrow Sodali LLC at 1-800-607-0088.
Thank you for your investment in Aytu BioPharma, Inc. and for taking the time to vote your shares.
Sincerely,
Joshua Disbrow
Chairman and Chief Executive Officer