Note 12 - Stockholders' Equity (Details Textual) | | | | | | 3 Months Ended | 5 Months Ended | 9 Months Ended | 12 Months Ended | | | | | | | | | | | |
May 01, 2023 USD ($) $ / shares shares | Apr. 27, 2023 USD ($) $ / shares | Nov. 15, 2022 $ / shares | Sep. 09, 2022 USD ($) $ / shares shares | Oct. 29, 2021 USD ($) $ / shares shares | Sep. 30, 2023 USD ($) $ / shares shares | Sep. 30, 2022 USD ($) | Sep. 30, 2023 USD ($) $ / shares shares | Sep. 30, 2023 USD ($) $ / shares shares | Sep. 30, 2022 USD ($) | Dec. 31, 2019 shares | Jun. 30, 2023 USD ($) | Apr. 30, 2023 USD ($) $ / shares shares | Apr. 26, 2023 USD ($) | Dec. 31, 2022 $ / shares shares | Nov. 10, 2022 USD ($) | Sep. 08, 2022 USD ($) $ / shares | Jan. 31, 2022 USD ($) | Dec. 31, 2021 USD ($) | Jan. 15, 2021 $ / shares shares | Sep. 30, 2020 $ / shares | Jul. 31, 2020 $ / shares |
Common Stock, Shares Authorized (in shares) | | | | | | 150,000,000 | | | 150,000,000 | 150,000,000 | | | | | | | 150,000,000 | | | | | | | |
Preferred Stock, Shares Authorized (in shares) | | | | | | | | | | | | | | | | | 5,000,000 | | | | | | | |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares | | | | | | $ 2.18 | | | $ 2.18 | $ 2.18 | | | | | | | $ 7.7 | | | | | | | |
Gain (Loss) on Modification of Warrants | $ | | | | | | $ 0 | $ (1,922,000) | | | $ (285,000) | $ (1,922,000) | | | | | | | | | | | | | |
Fair Value Adjustment of Warrants | $ | | | | | | 0 | (2,414,000) | | | (216,000) | (4,470,000) | | | | | | | | | | | | | |
Proceeds from Warrant Exercises | $ | | | | | | | | | | 0 | 1,703,000 | | | | | | | | | | | | | |
Preferred Stock, Change in Conversion Price, Income Statement Impact | $ | | | | | | 0 | 0 | | | $ 194,000 | 0 | | | | | | | | | | | | | |
Class of Warrant or Right, Issued During Period (in shares) | | | | | | | | | | 5,076,000 | | | | | | | | | | | | | | |
The 2022 Private Placement [Member] | | | | | | | | | | | | | | | | | | | | | | | | |
Proceeds from Issuance or Sale of Equity, Total | $ | | | | $ 3,200,000 | | | | | | | | | | | | | | | | | | | | |
The 2022 Private Placement [Member] | Conversion of Series C Preferred Stock to Common Stock [Member] | | | | | | | | | | | | | | | | | | | | | | | | |
Preferred Stock, Convertible, Shares Issuable (in shares) | | | | 516,750 | | | | | | | | | | | | | | | | | | | | |
The 2021 Private Placement Program [Member] | Conversion of Series B Preferred Stock to Common Stock [Member] | Stock Restatement From Reverse Stock Split [Member] | | | | | | | | | | | | | | | | | | | | | | | | |
Preferred Stock, Convertible, Shares Issuable (in shares) | | | | | 1,071,429 | | | | | | | | | | | | | | | | | | | |
Series C Preferred Stock [Member] | | | | | | | | | | | | | | | | | | | | | | | | |
Preferred Stock, Convertible, Conversion Price (in dollars per share) | $ / shares | | $ 6.3 | | | | | | | | | | | | | | | | | | | | | | |
Preferred Stock, Change in Conversion Price, Income Statement Impact | $ | | | | | | $ 0 | 0 | [1] | | $ 194,000 | 0 | [1] | | | | | | | | | | | | |
Preferred Stock, Shares Outstanding (in shares) | | | | | | 1,000 | | | 1,000 | 1,000 | | | | | | | 2,000 | | | | | | | |
Series C Preferred Stock [Member] | The 2022 Private Placement [Member] | | | | | | | | | | | | | | | | | | | | | | | | |
Stock Issued During Period, Shares, New Issues (in shares) | | | | 3,250 | | | | | | | | | | | | | | | | | | | | |
Preferred Stock, Purchase Price (in dollars per share) | $ / shares | | | | $ 1,000 | | | | | | | | | | | | | | | | | | | | |
Preferred Stock, Convertible, Conversion Price (in dollars per share) | $ / shares | | | | $ 6.3 | | | | | | | | | | | | | | | | | | | | |
Preferred Stock, Convertible, Conversion Ratio | | | | 159 | | | | | | | | | | | | | | | | | | | | |
Series C Preferred Stock [Member] | The 2023 Private Placement [Member] | | | | | | | | | | | | | | | | | | | | | | | | |
Preferred Stock, Convertible, Conversion Price (in dollars per share) | $ / shares | | | | | | $ 1.3 | | | $ 1.3 | $ 1.3 | | | | | | | | | | | | | | |
Preferred Stock, Convertible, Conversion Ratio | | 770 | | | | 770 | | | 770 | 770 | | | | | | | | | | | | | | |
Preferred Stock, Change in Conversion Price, Income Statement Impact | $ | | $ 194,000 | | | | | | | | | | | | | | | | | | | | | | |
Preferred Stock, Fair Value Disclosure | $ | | | | | | $ 1,100,000 | | | $ 1,100,000 | $ 1,100,000 | | | | | | $ 900,000 | | | | | | | | |
Conversion of Stock, Shares Converted (in shares) | | | | | | | | | 2,153 | | | | | | | | | | | | | | | |
Preferred Stock, Shares Outstanding (in shares) | | | | | | 1,097 | | | 1,097 | 1,097 | | | | | | | | | | | | | | |
Series B Preferred Stock [Member] | | | | | | | | | | | | | | | | | | | | | | | | |
Preferred Stock, Shares Authorized (in shares) | | | | | | 5,000,000 | | | 5,000,000 | 5,000,000 | | | | | | | 5,000,000 | | | | | | | |
Preferred Stock, Convertible, Conversion Price (in dollars per share) | $ / shares | | $ 6.3 | $ 6.3 | $ 0.18 | | | | | | | | | | | | | | | $ 0.4 | | | | | |
Preferred Stock, Convertible, Conversion Ratio | | | 159 | | | | | | | | | | | | | | | | | | | | | |
Preferred Stock, Change in Conversion Price, Income Statement Impact | $ | | | | $ 5,700,000 | | $ 0 | $ 5,657,000 | [1] | | $ 1,802,000 | $ 5,657,000 | [1] | | | | | | | | | | | | |
Preferred Stock, Fair Value Disclosure | $ | | | | $ 12.5 | | | | | | | | | | | | | | | $ 6,800,000 | | | | | |
Preferred Stock, Shares Outstanding (in shares) | | | | | | 6,000 | | | 6,000 | 6,000 | | | | | | | 12,000 | | | | | | | |
Convertible Preferred Stock, Shares Issued upon Conversion (in shares) | | | | 5,556 | | | | | | | | | | | | | | | | | | | | |
Series B Preferred Stock [Member] | The 2023 Private Placement [Member] | | | | | | | | | | | | | | | | | | | | | | | | |
Preferred Stock, Convertible, Conversion Price (in dollars per share) | $ / shares | | $ 1.3 | | | | | | | | | | | | | | | | | | | | | | |
Preferred Stock, Convertible, Conversion Ratio | | 770 | | | | | | | | | | | | | | | | | | | | | | |
Preferred Stock, Change in Conversion Price, Income Statement Impact | $ | | $ 1,800,000 | | | | | | | | | | | | | | | | | | | | | | |
Preferred Stock, Fair Value Disclosure | $ | | | | | | | | | | | | | | $ 10,500,000 | | 8,700,000 | | | | | | | | |
Conversion of Stock, Shares Converted (in shares) | | | | | | | | | 8,850 | | | | | | | | | | | | | | | |
Preferred Stock, Shares Outstanding (in shares) | | | | | | 6,150 | | | 6,150 | 6,150 | | | | | | | | | | | | | | |
Series B Preferred Stock [Member] | The 2021 Private Placement Program [Member] | | | | | | | | | | | | | | | | | | | | | | | | |
Stock Issued During Period, Shares, New Issues (in shares) | | | | | 15,000 | | | | | | | | | | | | | | | | | | | |
Preferred Stock, Purchase Price (in dollars per share) | $ / shares | | | | | $ 1,000 | | | | | | | | | | | | | | | | | | | |
Preferred Stock, Convertible, Conversion Price (in dollars per share) | $ / shares | | | | | $ 0.4 | | | | | | | | | | | | | | | | | | | |
Preferred Stock, Convertible, Conversion Ratio | | | | | 2,500 | | | | | | | | | | | | | | | | | | | |
Proceeds from Issuance of Preferred Stock and Preference Stock | $ | | | | | $ 14,900,000 | | | | | | | | | | | | | | | | | | | |
Certain Previously Issued Warrants [Member] | | | | | | | | | | | | | | | | | | | | | | | | |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | | | | | | | | | | | | | | | 1,724,455 | | | | | | | | | |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares | $ 1.5 | | | | | | | | | | | | | | $ 6.3 | | | | | | | | | |
The Amended November 2021 Warrants [Member] | | | | | | | | | | | | | | | | | | | | | | | | |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | | | | 803,574 | | | | | | | | | | | | | | | | | | | | |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares | | | | $ 6.3 | | | | | | | | | | | | | | | | | | | | |
Warrants and Rights Outstanding | $ | | | | $ 3,500,000 | | | | | | | | | | | | | | | | | | | | |
Amended November 2021 Warrants Exercisable for 1.50 [Member] | | | | | | | | | | | | | | | | | | | | | | | | |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | 535,716 | | | | | | | | | | | | | | | | | | | | | | | |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares | $ 1.5 | | | | | | | | | | | | | | | | | | | | | | | |
Amended November 2021 Warrants Exercisable for 6.50 [Member] | | | | | | | | | | | | | | | | | | | | | | | | |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | 267,858 | | | | | | | | | | | | | | | | | | | | | | | |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares | $ 6.3 | | | | | | | | | | | | | | | | | | | | | | | |
The Amended July 2020 Warrants [Member] | | | | | | | | | | | | | | | | | | | | | | | | |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | 77,145 | | | | | | | | | | | | | | | | | | | | | | | |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares | $ 1.5 | | | | | | | | | | | | | | | | | | | | | | | |
The July 2020 and November 2021 Warrants [Member] | | | | | | | | | | | | | | | | | | | | | | | | |
Gain (Loss) on Modification of Warrants | $ | $ 1,900,000 | | | | | | | | | | | | | | | | | | | | | | | |
Warrants and Rights Outstanding | $ | $ 5,200,000 | | | | | | | | | | | | | | $ 3,300,000 | | | | | | | | | |
September 2022 Warrants [Member] | | | | | | | | | | | | | | | | | | | | | | | | |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | | | | | | 327,860 | | | 327,860 | 327,860 | | | | | | | | | | | | | | |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares | | | | $ 0.18 | | | | | | | | | | | | | | | | | | | | |
Warrants and Rights Outstanding | $ | | | | $ 1,400,000 | | $ 94,000 | | | $ 94,000 | $ 94,000 | | | | | | 48,000 | | $ 500,000 | | | | | | |
Fair Value Adjustment of Warrants | $ | | | | | | | | | | $ 46,000 | | | | | | | | | | | | | | |
The November 2021 Warrants [Member] | | | | | | | | | | | | | | | | | | | | | | | | |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | | | | | | 803,574 | | | 803,574 | 803,574 | | | | | | | | | | | | | | |
Warrants and Rights Outstanding | $ | | | | | | $ 230,000 | | | $ 230,000 | $ 230,000 | | | | | | 112,000 | | 1,300,000 | | $ 7,500,000 | $ 9,600,000 | | | |
Fair Value Adjustment of Warrants | $ | | | | | | | | | | $ 117,000 | | | | | | | | | | | | | | |
Proceeds from Warrant Exercises | $ | | | | $ 700,000 | | | | | | | | | | | | | | | | | | | | |
The November 2021 Warrants [Member] | Stock Restatement From Reverse Stock Split [Member] | | | | | | | | | | | | | | | | | | | | | | | | |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares | | | | $ 6.3 | | | | | | | | | | | | | | | | | | | | |
Amended July 2020 Warrants [Member] | | | | | | | | | | | | | | | | | | | | | | | | |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | | | | | | 77,145 | | | 77,145 | 77,145 | | | | | | | | | | | | | | |
Warrants and Rights Outstanding | $ | | | | $ 300,000 | | | | | | | | | | | | | | $ 100,000 | | | | | | |
Proceeds from Warrant Exercises | $ | | | | 1,400,000 | | | | | | | | | | | | | | | | | | | | |
September 2022 Warrants Exercisable for 1.50 [Member] | | | | | | | | | | | | | | | | | | | | | | | | |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | 238,574 | | | | | | | | | | | | | | | | | | | | | | | |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares | $ 1.5 | | | | | | | | | | | | | | | | | | | | | | | |
September 2022 Warrants Exercisable for 6.50 [Member] | | | | | | | | | | | | | | | | | | | | | | | | |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | 89,286 | | | | | | | | | | | | | | | | | | | | | | | |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares | $ 6.3 | | | | | | | | | | | | | | | | | | | | | | | |
The 2022 Warrant Reprice Transaction [Member] | | | | | | | | | | | | | | | | | | | | | | | | |
Proceeds from Warrant Exercises | $ | | | | 2,100,000 | | | | | | | | | | | | | | | | | | | | |
Payments of Stock Issuance Costs | $ | | | | 529,000 | | | | | | | | | | | | | | | | | | | | |
Payments of Stock Issuance Costs Allocated to Warrants | $ | | | | 166,000 | | | | | | | | | | | | | | | | | | | | |
Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs | $ | | | | $ 363,000 | | | | | | | | | | | | | | | | | | | | |
The 2022 Warrant Reprice Transaction [Member] | Ladenburg Thalmann and Co. Inc. [Member] | | | | | | | | | | | | | | | | | | | | | | | | |
Exercise of Warrants, Commission, Percent | | | | 8% | | | | | | | | | | | | | | | | | | | | |
The 2022 Private Placement Short Term Warrants [Member] | | | | | | | | | | | | | | | | | | | | | | | | |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | | | | 515,876 | | | | | | | | | | | | | | | | | | | | |
The 2022 Private Placement Long Term Warrants [Member] | | | | | | | | | | | | | | | | | | | | | | | | |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | | | | 515,876 | | | | | | | | | | | | | | | | | | | | |
The 2022 Private Placement Long Term Warrants Exercisable for 1.50 [Member] | | | | | | | | | | | | | | | | | | | | | | | | |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | 873,020 | | | | | | | | | | | | | | | | | | | | | | | |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares | $ 1.5 | | | | | | | | | | | | | | | | | | | | | | | |
The 2022 Private Placement Long Term Warrants Exercisable for 6.50 [Member] | | | | | | | | | | | | | | | | | | | | | | | | |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | 158,732 | | | | | | | | | | | | | | | | | | | | | | | |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares | $ 6.3 | | | | | | | | | | | | | | | | | | | | | | | |
May 2023 Warrants [Member] | | | | | | | | | | | | | | | | | | | | | | | | |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares | | $ 1.3 | | | | | | | | | | | | | | | | | | | | | | |
Warrants and Rights Outstanding | $ | $ 1,600,000 | | | | | $ 1,400,000 | | | $ 1,400,000 | $ 1,400,000 | | | | | | | | | | | | | | |
Fair Value Adjustment of Warrants | $ | | | | | | | | | | $ 216,000 | | | | | | | | | | | | | | |
Preferred Stock, Convertible, Conversion Price (in dollars per share) | $ / shares | | $ 1.3 | | | | | | | | | | | | | | | | | | | | | | |
Series A-1 Warrants [Member] | | | | | | | | | | | | | | | | | | | | | | | | |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | | | | | | 515,876 | | | 515,876 | 515,876 | | | | | | | | | | | | | | |
Series A-2 Warrants [Member] | | | | | | | | | | | | | | | | | | | | | | | | |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | | | | | | 515,876 | | | 515,876 | 515,876 | | | | | | | | | | | | | | |
Series A-1 Warrants and Series A-2 Warrants [Member] | | | | | | | | | | | | | | | | | | | | | | | | |
Warrants and Rights Outstanding | $ | | | | | | $ 216,000 | | | $ 216,000 | $ 216,000 | | | | | | $ 93,000 | | | | | | | | |
Fair Value Adjustment of Warrants | $ | | | | | | | | | | $ 122,000 | | | | | | | | | | | | | | |
The 2021 Warrants [Member] | Stock Restatement From Reverse Stock Split [Member] | | | | | | | | | | | | | | | | | | | | | | | | |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | | | | | 1,071,429 | | | | | | | | | | | | | | | | | | | |
The 2019 Ladenburg Warrants [Member] | Stock Restatement From Reverse Stock Split [Member] | | | | | | | | | | | | | | | | | | | | | | | | |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares | | | | | | | | | | | | | | | | | | | | | | | $ 34.65 | |
Class of Warrant or Right, Issued During Period (in shares) | | | | | | | | | | | | | 4,799 | | | | | | | | | | | |
The July 2020 Warrants [Member] | | | | | | | | | | | | | | | | | | | | | | | | |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | | | | | | 59,960 | | | 59,960 | 59,960 | | | | | | | | | | | | | | |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares | | | | | | | | | | | | | | | | | | | | | | | | $ 57.75 |
TLF Bio Innovation 2021 Warrants [Member] | | | | | | | | | | | | | | | | | | | | | | | | |
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares) | | | | | | | | | | | | | | | | | | | | | | 429 | | |
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares | | | | | | | | | | | | | | | | | | | | | | $ 23.51 | | |
Reverse Stock Split [Member] | | | | | | | | | | | | | | | | | | | | | | | | |
Stockholders' Equity Note, Stock Split, Conversion Ratio | | | 35 | | | | | | | | | | | | | | | | | | | | | |
|
[1]After giving retroactive effect to a 1-for-35 reverse stock split that became effective November 15, 2022. |