Pacira BioSciences (PCRX) 8-K Changes in Registrant's Certifying Accountant

Exhibit 16.1

December 14, 2015

Securities and Exchange Commission

100 F Street, N.E.

Washington, D.C. 20549-7561

Dear Sirs/Madams:

We have read the statements made by Pacira Pharmaceuticals, Inc., which we understand will be filed with the Securities and Exchange Commission, pursuant to Item 4.01 of Form 8-K, as part of the Form 8-K of Pacira Pharmaceuticals, Inc. dated December 17, 2015. We agree with the statements concerning our Firm in such Form 8-K.

Very truly yours,

Roseland, New Jersey