Targanta Therapeutics 10-Q 2008 Q2 Quarterly report

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 10-Q

(Mark One)

x Quarterly report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934:

For the quarterly period ended June 30, 2008

OR

¨ Transition report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934:

For the transition period from              to             

Commission file number:

Targanta Therapeutics Corporation

(Exact Name of Registrant as Specified in Its Charter)

Delaware	20-3971077
(State or Other Jurisdiction of Incorporation or Organization)	(I.R.S. Employer Identification No.)

222 Third Street, Suite 2300, Cambridge, Massachusetts 02142-1122

(Address of Principal Executive Offices) (Zip Code)

(617) 577-9020

(Registrant’s Telephone Number, Including Area Code)

Indicate by check mark whether the registrant:(1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days.    Yes  x    No  ¨

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of “large accelerated filer,” “accelerated filer” and “smaller reporting company” in Rule 12b-2 of the Exchange Act.

Large accelerated filer	¨	Accelerated filer	¨
Non-accelerated filer	x  (Do not check if a smaller reporting company)	Smaller reporting company	¨

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).    ¨  Yes    x  No

As of July 31, 2008, there were 20,971,834 shares of the Registrant’s common stock outstanding.

TARGANTA THERAPEUTICS CORPORATION

QUARTERLY REPORT

ON FORM 10-Q

INDEX

		Page
PART I. FINANCIAL INFORMATION
Item 1.	Financial Statements (Unaudited)	3
	Condensed Consolidated Balance Sheets as of June 30, 2008 and December 31, 2007	4
	Condensed Consolidated Statements of Operations for the Three and Six Months Ended June 30, 2008 and 2007 and the cumulative period from May 20, 1997 (date of inception) through June 30, 2008	5
	Condensed Consolidated Statements of Cash Flows for the Six Months Ended June 30, 2008 and 2007 and the cumulative period from May 20, 1997 (date of inception) through June 30, 2008	6
	Notes to Condensed Consolidated Financial Statements	8
Item 2.	Management’s Discussion and Analysis of Financial Condition and Results of Operations	16
Item 3.	Quantitative and Qualitative Disclosures about Market Risk	22
Item 4.	Controls and Procedures	23
PART II. OTHER INFORMATION
Item 1.	Legal Proceedings	24
Item 1A.	Risk Factors	24
Item 2.	Unregistered Sales of Equity Securities and Use of Proceeds	24
Item 3.	Defaults Upon Senior Securities	24
Item 4.	Submission of Matters to a Vote of Security Holders	24
Item 5.	Other Information	25
Item 6.	Exhibits	25
Signatures		26

2

PART I. FINANCIAL INFORMATION

FORWARD-LOOKING STATEMENTS

This Quarterly Report on Form 10-Q contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that involve risks and uncertainties, as well as assumptions that, if they never materialize or prove incorrect, could cause the results of Targanta Therapeutics Corporation to differ materially from those expressed or implied by such forward-looking statements. All statements other than statements of historical fact are statements that could be deemed forward-looking statements, including any projections of financing needs, revenue, expenses, earnings or losses from operations, or other financial items; any statements of the plans, strategies and objectives of management for future operations, any statements concerning product research, development and commercialization plans and timelines; any statements regarding safety and efficacy of product candidates, any statements of expectation or belief; and any statements of assumptions underlying any of the foregoing. In addition, forward looking statements may contain the words “believe,” “anticipate,” “expect,” “estimate,” “intend,” “plan,” “project,” “will be,” “will continue,” “will result,” “seek,” “could,” “may,” “might,” or any variations of such words or other words with similar meanings.

The risks, uncertainties and assumptions referred to above include risks that are described under the title “Risk Factors” in our Annual Report on Form 10-K for the fiscal year ended December 31, 2007 filed on March 27, 2008 and our Quarterly Report on Form 10-Q for the quarterly period ended March 31, 2008 filed on May 13, 2008 with the Securities and Exchange Commission, and that are otherwise described from time to time in our Securities and Exchange Commission reports filed after this report.

The forward-looking statements included in this quarterly report represent our estimates as of the date of this quarterly report. We specifically disclaim any obligation to update these forward-looking statements in the future. These forward-looking statements should not be relied upon as representing our estimates or views as of any date subsequent to the date of this quarterly report.

Item 1. Financial Statements – Unaudited

The financial information set forth below should be read in conjunction with our “Management’s Discussion and Analysis of Financial Condition and Results of Operations” appearing elsewhere in this Quarterly Report on Form 10-Q.

3

Targanta Therapeutics Corporation

(A development-stage company)

Condensed Consolidated Balance Sheets

(in thousands, except share and per share amounts)

(Unaudited)

	June 30, 2008			December 31, 2007
Assets
Current assets:
Cash and cash equivalents	$	36,363		$	32,955
Short-term investments		22,319			56,798
Restricted cash		491			506
Investment tax credits recoverable		516			757
Prepaid expenses and other current assets		1,372			1,630
Total current assets		61,061			92,646
Property and equipment, net		1,276			1,350
Deferred financing costs		86			103
Deposits		72			50
Total assets	$	62,495		$	94,149
Liabilities and Stockholders’ Equity
Current liabilities:
Accounts payable	$	2,848		$	718
Accrued expenses		9,730			5,873
Income tax payable		674			2,731
Current portion of deferred rent		34			24
Current portion of long-term debt		6,591			5,480
Total current liabilities		19,877			14,826
Deferred rent		78			100
Other long-term liabilities		181			63
Long-term debt		10,991			14,287
Commitments (Note 4)
Stockholders’ equity:
Preferred Stock, par value $0.0001; 5,000,000 shares authorized, no shares issued and outstanding		—			—
Common stock, par value $0.0001; 35,000,000 shares authorized, 20,971,834 and 20,969,257 shares issued and outstanding at June 30, 2008 and December 31, 2007, respectively		2			2
Additional paid-in capital		191,476			190,137
Accumulated other comprehensive income		1,551			1,665
Deficit accumulated during the development stage		(161,661	)		(126,931	)
Total stockholders’ equity		31,368			64,873
Total liabilities and stockholders’ equity	$	62,495		$	94,149

The accompanying notes are an integral part of these consolidated financial statements.

4

Targanta Therapeutics Corporation

(A development-stage company)

Condensed Consolidated Statements of Operations

(in thousands, except share and per share amounts)

(Unaudited)

	Three Months Ended June 30,						Six Months Ended June 30,						For the Period from May 20, 1997 (date of inception) through June 30, 2008
	2008			2007			2008			2007
Operating expenses
Research and development (1)	$	12,859		$	9,405		$	27,138		$	14,844		$	92,533
Acquired in-process research and development		—			—			—			9,500			29,000
General and administrative (1)		4,189			2,847			7,807			4,782			28,771
Total operating expenses		17,048			12,252			34,945			29,126			150,304
Other income (expense)
Interest income		466			556			1,334			1,014			4,791
Interest expense		(602	)		273			(1,245	)		(1,937	)		(20,360	)
Foreign exchange gain (loss)		5			(789	)		(14	)		(853	)		(1,948	)
Gain on disposal of property and equipment		—			—			—			—			47
Other income (expense), net		(131	)		40			75			(1,776	)		(17,470	)
Loss before income tax benefit		(17,179	)		(12,212	)		(34,870	)		(30,902	)		(167,774	)
Income tax benefit		74			83			140			54			6,113
Net loss	$	(17,105	)	$	(12,129	)	$	(34,730	)	$	(30,848	)	$	(161,661	)
Net loss per share—basic and diluted	$	(0.82	)	$	(479.78	)	$	(1.66	)	$	(1,229.07	)
Weighted average number of common shares used in net loss per share—basic and diluted		20,970,490			25,282			20,969,873			25,282
(1)    Amounts include stock-based compensation expense, as follows:
Research and development	$	312		$	739		$	569		$	747		$	2,461
General and administrative	$	546		$	592		$	761		$	603		$	2,547

The accompanying notes are an integral part of these consolidated financial statements.

5

Targanta Therapeutics Corporation

(A development-stage company)

Condensed Consolidated Statements of Cash Flows

(in thousands)

(Unaudited)

	Six Months Ended June 30,						For the Period from May 20, 1997 (date of inception) through June 30, 2008
	2008			2007
Cash flows from operating activities:
Net loss	$	(34,730	)	$	(30,848	)	$	(161,661	)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization		327			226			3,232
Stock-based compensation expense		1,330			1,350			5,008
Gain on disposal of property and equipment		—			—			(47	)
Amortization of deferred financing costs		16			338			695
Deferred rent		(10	)		17			70
Acquired in-process research and development		—			7,500			26,000
Non-cash interest expense		154			1,419			17,481
Unrealized foreign exchange loss		17			1,080			1,675
Changes in operating assets and liabilities:
Investment tax credits recoverable		230			(156	)		75
Prepaid expenses and other current assets		258			(634	)		(1,271	)
Deposits		(23	)		—			(70	)
Accounts payable		2,130			(142	)		3,124
Accrued expenses		3,863			2,772			7,191
Income tax payable		(2,055	)		2,336			282
Reimbursement from landlord		—			30			30
Deferred income tax		—			(2,212	)		(222	)
Net cash used in operating activities		(28,493	)		(16,924	)		(98,408	)
Cash flows from investing activities:
Purchases of property and equipment		(253	)		(660	)		(3,063	)
Proceeds from sale of property and equipment		—			—			105
Increase in restricted cash		—			—			(282	)
Proceeds from sales and maturities of short-term investments		47,262			—			66,551
Purchases of short-term investments		(12,896	)		(14,852	)		(88,174	)
Net cash provided by (used in) investing activities		34,113			(15,512	)		(24,863	)
Cash flows from financing activities:
Proceeds from bank loan		—			—			327
Payments on bank loan		—			—			(337	)
Proceeds from issuance of note payable		—			—			6,470
Payments on note payable		—			—			(10,044	)
Principal payments under capital leases		—			—			(1,273	)
Proceeds from issuance of convertible notes		—			—			11,763
Payments on convertible notes		—			(2,177	)		(2,177	)
Proceeds from issuance of convertible debentures		—			—			14,028
Proceeds from issuance of long-term debt		—			—			20,000
Payments on long-term debt		(2,222	)		—			(2,222	)
Proceeds from issuance of preferred stock and warrants, net of issuance costs		—			57,825			69,154
Proceeds from issuance of common stock, net of issuance costs		10			—			53,693
Deferred financing costs		—			(802	)		(812	)
Net cash (used in) provided by financing activities		(2,212	)		54,846			158,570
Net increase in cash and cash equivalents		3,408			22,410			35,299
Effect of foreign currency on cash and cash equivalents		—			—			1,064
Cash and cash equivalents, beginning of period		32,955			12,104			—
Cash and cash equivalents, end of period	$	36,363		$	34,514		$	36,363

6

Targanta Therapeutics Corporation

(A development-stage company)

Condensed Consolidated Statements of Cash Flows — (continued)

(in thousands)

(Unaudited)

	Six Months Ended June 30,					For the Period from May 20, 1997 (date of inception) Through June 30, 2008
	2008		2007
Supplemental disclosure of cash flow information
Cash paid for interest	$	908	$	180		$	1,957
Cash paid for income taxes	$	2,027	$	—		$	2,027
Supplemental disclosure of non-cash financing activities
Discount to note payable for warrant valuation	$	—	$	—		$	406
Issuance of InterMune convertible note	$	—	$	7,500		$	24,000
Reduction of InterMune convertible note	$	—	$	(3,000	)	$	(3,000	)
Discount to convertible notes for warrant valuation and beneficial conversion features	$	—	$	—		$	11,715
Discount to convertible debentures for beneficial conversion features	$	—	$	—		$	8,724
Conversion of convertible debt into preferred stock	$	—	$	(38,990	)	$	(46,642	)
Reversal of beneficial conversion features in connection with conversion of convertible debentures	$	—	$	(7,026	)	$	(7,026	)
Discount to long-term debt for warrant valuation	$	—	$	—		$	253
Accretion of redeemable convertible preferred stock to redemption value	$	—	$	225		$	5,327
Conversion of preferred stock into common stock	$	—	$	—		$	121,534

The accompanying notes are an integral part of these consolidated financial statements.

7

Targanta Therapeutics Corporation

(A development-stage company)

Notes to Condensed Consolidated Financial Statements

(in thousands, except share and per share amounts)

(Unaudited)

1. Basis of Presentation

Targanta Therapeutics Corporation (“Parent”), a Delaware corporation, was incorporated on December 6, 2005 to become the parent entity of Targanta Therapeutics Inc. (“Targanta Québec”) (previously PhageTech Inc.) and Targanta Therapeutics (Ontario) Inc. (“Targanta Ontario”) as part of a reorganization that was effective December 23, 2005. Targanta Québec, a Canadian company, was incorporated on May 20, 1997 and Targanta Ontario, a Canadian company, was incorporated on December 22, 2005. Targanta Therapeutics Corporation together with its subsidiaries (the “Company”) is a biopharmaceutical company focused on developing and commercializing antibacterial drugs to treat serious infections acquired or treated in the hospital or other institutional settings. Oritavancin, the Company’s lead product candidate, is a once-daily, semi-synthetic lipoglycopeptide antibiotic with rapid bactericidal activity against all studied clinically relevant serious gram-positive pathogens, including multi-resistant strains. The Company has commenced its planned principal operations; however, the Company has not generated any revenue from its operations. Accordingly, the Company is considered to be in the development stage as defined in Statement of Financial Accounting Standards (“SFAS”) No. 7,Accounting and Reporting by Development Stage Enterprises. The Company’s activities are carried out at its facilities in Cambridge, Massachusetts; Indianapolis, Indiana; and Montreal, Québec, Canada.

The accompanying unaudited condensed consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States (“GAAP”) for interim financial reporting and as required by Regulation S-X, Rule 10-01. Accordingly, they do not include all of the information and footnotes required by GAAP for complete financial statements. In the opinion of management, all adjustments (including those which are normal and recurring) considered necessary for a fair presentation of the interim financial information have been included. When preparing financial statements in conformity with GAAP, the Company must make estimates and assumptions that affect the reported amounts of assets, liabilities, revenues, expenses and related disclosures at the date of the financial statements. Actual results could differ from those estimates. Additionally, operating results for the three and six months ended June 30, 2008 are not necessarily indicative of the results that may be expected for any other interim period or for the year ending December 31, 2008.

The accompanying unaudited condensed consolidated financial statements and notes thereto should be read in conjunction with the audited consolidated financial statements for the year ended December 31, 2007 included in the Company’s Annual Report on Form 10-K.

2. Summary of Significant Accounting Policies

Principles of Consolidation

The unaudited condensed consolidated financial statements include the accounts of the Parent and its wholly-owned subsidiaries. All significant intercompany accounts and transactions have been eliminated.

Cash and Cash Equivalents

The Company considers all short-term, highly liquid investments with original maturities of three months or less at acquisition date to be cash equivalents. At June 30, 2008, the Company had invested its excess cash in money market accounts, overnight investment accounts, certificates of deposit, commercial paper, United States treasury bills and debt obligations of government agencies. At December 31, 2007, the Company had invested its excess cash in money market accounts, overnight investment accounts, certificates of deposit and commercial paper. The Company did not hold any investments in mortgage-backed or auction rate securities at June 30, 2008 or December 31, 2007.

8

Targanta Therapeutics Corporation

(A development-stage company)

Notes to Condensed Consolidated Financial Statements — (continued)

(in thousands, except share and per share amounts)

(Unaudited)

Short-term Investments

The Company accounts for its investments in accordance with SFAS No. 115,Accounting for Certain Investments in Debt and Equity Securities (“SFAS No. 115”). In accordance with SFAS No. 115, the Company has classified all of its investments as available-for-sale. The Company’s investments are reported at fair value, with any unrealized gains or losses reported as a separate component of stockholders’ equity as accumulated other comprehensive income.

Short-term investments included the following at June 30, 2008 and December 31, 2007:

	Amortized cost		Unrealized gains		Unrealized losses			Fair value
June 30, 2008—
Commercial paper	$	9,846	$	12	$	—		$	9,858
Asset backed securities		8,857		20		—			8,877
Debt obligations of government agencies		3,585		—		(1	)		3,584
	$	22,288	$	32	$	(1	)	$	22,319
December 31, 2007—
Commercial paper	$	34,080	$	121	$	—		$	34,201
Corporate obligations		4,861		—		(6	)		4,855
Asset backed securities		17,725		18		(1	)		17,742
	$	56,666	$	139	$	(7	)	$	56,798

All short-term investments have contractual maturities of less than one year.

The aggregate fair value of investments with unrealized losses was $3,584 and approximately $6,824 at June 30, 2008 and December 31, 2007, respectively. At June 30, 2008, 4 investments were in an unrealized loss position. The Company reviews its investments for other-than-temporary impairment whenever the fair value of an investment is less than amortized cost and evidence indicates that an investment’s carrying amount is not recoverable within a reasonable period of time. To determine whether an impairment is other-than-temporary, the Company considers whether it has the ability and intent to hold the investment until a market price recovery and considers whether evidence indicating the cost of the investment is recoverable outweighs evidence to the contrary.

The cost of securities sold is determined based on the specific identification method for purposes of recording realized gains and losses. Gross realized gains and losses on the sales of investments have not been material to the Company’s consolidated results of operations.

Restricted Cash

The Company maintains restricted cash in the form of a guaranteed investment certificate of approximately $491 (CAN$500) collateralizing an available credit facility of approximately $491 (CAN$500), comprised of a credit line of approximately $275 (CAN$280) and letters of guarantee maturing in March 2009 amounting to approximately $216 (CAN$220).

Concentration of Credit Risk

The Company maintains its cash, cash equivalents, short-term investments and restricted cash with high quality financial institutions, and accordingly, is subject to minimal credit risk. The Company performs periodic evaluations of the relative credit quality of investments and the Company’s policy is designed to limit exposure to any one institution or type of investment. The primary objective of the Company’s investment strategy is the preservation of the principal invested. Investment tax credits recoverable were due from the Canadian federal and Québec provincial governments. The Company does not maintain foreign exchange contracts or other off-balance sheet financial instruments.

9

Targanta Therapeutics Corporation

(A development-stage company)

Notes to Condensed Consolidated Financial Statements — (continued)

(in thousands, except share and per share amounts)

(Unaudited)

Fair Value of Financial Instruments

Cash, cash equivalents, short-term investments, restricted cash, investment tax credits recoverable, accounts payable, accrued expenses and the current portion of long-term debt are carried at amounts that approximate fair value at June 30, 2008 and December 31, 2007 due to their short-term maturities.

Long-term debt approximates fair value at June 30, 2008, as it bears interest at a rate approximating a market interest rate.

On January 1, 2008, the Company adopted the provisions of SFAS No. 157,Fair Value Measurements (“SFAS No. 157”) for its financial assets and other items that are recognized or disclosed at fair value on a recurring basis. This statement, among other things, defines fair value, establishes a framework for measuring fair value and expands disclosures about fair value measurements. In February 2008, the Financial Accounting Standards Board (“FASB”) issued FASB Staff Position 157-2 (“FSP 157-2”), which delays the effective date of SFAS No. 157 for all nonfinancial assets and nonfinancial liabilities, except those that are recognized or disclosed at fair value in the financial statements on a recurring basis, until fiscal years beginning after November 15, 2008 and interim periods within those years. The partial adoption of SFAS No. 157 for financial assets and liabilities recognized at fair value on a recurring basis, in accordance with FSP 157-2, did not have a material effect on the Company’s consolidated financial statements.

SFAS No. 157 clarifies that fair value is an exit price, representing the amount that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants. As such, fair value is a market-based measurement that should be determined based on assumptions that market participants would use in pricing an asset or liability. As a basis for considering such assumption, SFAS No. 157 established a three-tier fair value hierarchy, which prioritizes the inputs used in measuring fair value as follows:

• Level 1 — Observable inputs such as quoted prices in active markets;

• Level 2 — Inputs, other than the quoted prices in active markets, that are observable either directly or indirectly; and

• Level 3 — Unobservable inputs in which there is little or no market data, which require the reporting entity to develop its own assumptions.

The Company’s investment portfolio includes many fixed income securities that do not always trade on a daily basis. As a result, the pricing services used by the Company applied other available information as applicable through processes such as benchmark yields, benchmarking of like securities, sector groupings and matrix pricing to prepare evaluations. In addition, model processes were used to assess interest rate impact and develop prepayment scenarios. These models take into consideration relevant credit information, perceived market movements, sector news and economic events. The inputs into these models may include benchmark yields, reported trades, broker-dealer quotes, issuer spreads and other relevant data.

In accordance with the disclosure provisions of SFAS No. 157, the Company has classified assets measured at fair value on a recurring basis as follows:

			Fair Value Measurements at Reporting Date Using
Description	June 30, 2008		Quoted Prices in Active Markets for Identical Assets (Level 1)		Significant Other Observable Inputs (Level 2)		Significant Unobservable Inputs (Level 3)
Cash equivalents	$	18,158	$	16,660	$	1,498	$	—
Available-for-sale securities	$	22,319	$	3,584	$	18,735	$	—

10

Targanta Therapeutics Corporation

(A development-stage company)

Notes to Condensed Consolidated Financial Statements — (continued)

(in thousands, except share and per share amounts)

(Unaudited)

Research and Development Costs

The Company charges research and development costs to operations as incurred in accordance with SFAS No. 2,Accounting for Research and Development Costs and EITF Issue No. 07-3,Accounting for Nonrefundable Advance Payments for Goods or Services to Be Used in Future Research and Development Activities. Research and development costs are comprised of costs incurred in performing research and development activities, including salaries, benefits, facilities, research-related overhead, contracted services, license fees, and other external costs. Acquired in-process research and development having no alternative future use is written off at the time of acquisition. In addition, as pre-established research and development milestones under the Company’s various agreements are achieved, they are charged to acquired in-process research and development expense. Acquired in-process research and development expense for the six months ended June 30, 2007 includes a $2,000 cash payment and the fair value of the securities issued to InterMune, Inc. (“InterMune”) in connection with the Company’s achievement of certain milestones.

Net Loss per Share

The Company calculates net loss per share in accordance with SFAS No. 128,Earnings Per Share. Basic and diluted net loss per common share was determined by dividing net loss by the weighted average number of shares of common stock outstanding during the period. The Company’s potentially dilutive shares, which include convertible preferred stock, outstanding stock options exercisable for shares of common stock and warrants exercisable for common and preferred stock, have not been included in the computation of diluted net loss per share for all periods as the result would be anti-dilutive.

	Three Months Ended June 30,						Six Months Ended June 30,
	2008			2007			2008			2007
As reported:
Net loss	$	(17,105	)	$	(12,129	)	$	(34,730	)	$	(30,848	)
Accretion of Series B Redeemable Convertible Preferred Stock dividends		—			—			—			(225	)
Net loss applicable to common stockholders		(17,105	)		(12,129	)		(34,730	)		(31,073	)
Weighted average number of shares of common stock used in net loss per share – basic and diluted		20,970,490			25,282			20,969,873			25,282
Net loss per share applicable to common stockholders – basic and diluted	$	(0.82	)	$	(479.78	)	$	(1.66	)	$	(1,229.07	)

The following potentially dilutive securities have been excluded from the computation of diluted weighted average shares outstanding during the three and six months ended June 30, 2008 and 2007.

	Three and Six Months Ended June 30,
	2008	2007
Convertible preferred stock	—	9,935,665
Warrants outstanding	850,287	529,867
Options outstanding	3,685,391	2,250,914

11

Targanta Therapeutics Corporation

(A development-stage company)

Notes to Condensed Consolidated Financial Statements — (continued)

(in thousands, except share and per share amounts)

(Unaudited)

Comprehensive Income (Loss)

The Company has applied the provisions of SFAS No. 130,Reporting Comprehensive Income, which requires that all components of comprehensive income (loss) be reported in the period in which they are recognized. Comprehensive income (loss) is defined as the change in equity of a business enterprise during a period from transactions and other events and circumstances from non-owner sources. Other than the Company’s net loss, the other element of comprehensive income (loss) impacting the Company is unrealized gains on marketable securities.

	Three Months Ended June 30,						Six Months Ended June 30,
	2008			2007			2008			2007
As reported:
Net loss applicable to common stockholders	$	(17,105	)	$	(12,129	)	$	(34,730	)	$	(31,073	)
Other comprehensive income (loss):
Unrealized gain (loss) on marketable securities		(137	)		22			(114	)		22
Comprehensive loss	$	(17,242	)	$	(12,107	)	$	(34,844	)	$	(31,051	)

Canadian Part VI.I Tax

The Company has accrued the potential Canadian Part VI.I tax related to the cumulative dividend on its Series B Redeemable Convertible Preferred Stock. The Company applied the provisions of EITF Issue No. 95-9,Accounting for Tax Effects of Dividends in France in Accordance with FASB Statement No. 109, in accounting for the Canadian Part VI.I tax, which states that unless specific criteria are met, taxes on distributions should be treated as an income tax expense. The Part VI.I tax liability of approximately $2,731 was presented as a current tax liability in the December 31, 2007 condensed consolidated balance sheet. In February 2008, the Company paid approximately $2,026 of the Part VI.I tax liability to the Canadian tax authority. The Canadian government voted to approve, but has not given final approval to, a reduction in the Part VI.I tax rate. The February 2008 payment was made at the reduced tax rate. The remaining Part VI.I tax liability of approximately $662 is presented as a current tax liability in the June 30, 2008 condensed consolidated balance sheet and will be reversed if and when the Canadian government finally approves the Part VI.I tax rate reduction.

Investment Tax Credits

Canadian federal and Québec and Ontario provincial investment tax credits are accounted for as a reduction of the income tax expense in the period in which the credits are earned and when there is reasonable assurance of their recovery.

Segment and Geographic Information

SFAS No. 131,Disclosures about Segments of an Enterprise and Related Information (“SFAS No. 131”), established standards for reporting information about operating segments in annual financial statements and requires selected information about operating segments to be presented in interim financial reports issued to stockholders. SFAS No. 131 also established standards for disclosures about products and services and geographic areas. Operating segments are defined as components of an enterprise about which separate discrete financial information is available for evaluation by the chief operating decision maker, or decision-making group, in deciding how to allocate resources and in assessing performance. The Company views its operations and manages its business in one operating segment and the Company operates in only two geographic segments, the United States and Canada.

12

Targanta Therapeutics Corporation

(A development-stage company)

Notes to Condensed Consolidated Financial Statements — (continued)

(in thousands, except share and per share amounts)

(Unaudited)

The Company’s long-lived assets included the following:

	June 30, 2008		December 31, 2007
Domestic	$	830	$	850
Canada		446		500
	$	1,276	$	1,350

Recent Accounting Pronouncements

In December, 2007, EITF 07-01,Accounting for Collaborative Arrangements Related to the Development and Commercialization of Intellectual Property (“EITF 07-01”), was issued. EITF 07-01 prescribes the accounting for collaborations, requiring that, when certain characteristics exist in collaboration relationships, certain transactions between collaborators be recorded within expenses in the statement of operations on either a gross or net basis. The Company currently has no collaborations that are impacted by EITF 07-01. The Company will evaluate any future collaborations under this guidance, as appropriate.

Reclassifications

Certain reclassifications were made to prior year balances to conform to the current year’s presentation.

3. Accrued Expenses

Accrued expenses consist of the following:

	June 30, 2008		December 31, 2007
Payroll and benefits	$	1,388	$	1,382
Professional fees		364		545
Clinical expenses		3,513		3,202
Manufacturing and process development expenses		2,774		301
Other		1,691		443
	$	9,730	$	5,873

4. Commitments

The Company leases its laboratory and office space under operating lease agreements with various terms and renewal options with lease expirations ranging from 2009 through 2012. In addition to minimum lease commitments, these lease agreements require the Company to pay its pro rata share of property taxes and building operating expenses.

13

Targanta Therapeutics Corporation

(A development-stage company)

Notes to Condensed Consolidated Financial Statements — (continued)

(in thousands, except share and per share amounts)

(Unaudited)

5. Stock-Based Compensation

Stock Option Plans

At June 30, 2008, the Company’s 2005 Stock Option Plan (“2005 Plan”) provided for the grant of options for the purchase of 2,318,956 shares of common stock plus any shares of common stock covered by outstanding options under the Re-Amended and Restated Stock Option Plan of Targanta Québec (“Targanta Québec Plan”) that are forfeited and returned for reissuance under the Targanta Québec Plan, such number not to exceed 3,597 shares of common stock. The Company is no longer permitted to make grants under the 2005 Plan or the Targanta Québec Plan. As a result, at June 30, 2008, the maximum aggregate number of shares of common stock available for issuance under the 2005 Plan was 2,322,553, including 433 shares of common stock which are not available for future grant.

At June 30, 2008, the Company’s 2007 Stock Option and Incentive Plan (“2007 Plan”) provided for the grant of options for the purchase of 2,047,446 shares of common stock. The 2007 Plan permits the Company to make grants of incentive stock options, non-qualified stock options, stock appreciation rights, deferred stock awards, restricted stock awards, unrestricted stock awards and cash-based awards. The number of shares available for future grant under the 2007 Plan may be increased each year by an amount determined by the Company’s board of directors not to exceed 3.5% of all shares of the Company’s capital stock outstanding on December 31st of each preceding year. Accordingly, on February 6, 2008, the Company’s board of directors increased the aggregate number of shares available for grant under the 2007 Plan by 733,921. Generally, shares that are forfeited or canceled from awards under the 2007 Plan also will be available for future awards. In addition, awards that are returned to the Company’s 2005 Plan as a result of their expiration, cancellation, termination or repurchase are automatically made available for issuance under the 2007 Plan.

The Company adopted SFAS No. 123 (revised 2004),Share Based Payment (“SFAS No. 123(R)”), effective January 1, 2006. In connection with the adoption of SFAS No. 123(R), the Company reassessed the valuation methodology for stock options and the related input assumptions. The assessment of the valuation methodology resulted in the continued use of the Black-Scholes model. Prior to October 9, 2007, the date the Company’s Registration Statement on Form S-1, as amended, was declared effective, the Company was a private company and did not have relevant historical data to support its expected term and volatility. As such, the Company analyzed the expected term and volatility of several peer companies to support the assumptions used in its fair value calculations. The Company averaged the volatilities and expected terms of the peer companies with sufficient trading history, similar vesting terms and similar in-the-money option status to generate the assumptions detailed below.

The following table summarizes the weighted average assumptions the Company used in its grant date fair value calculations under SFAS No. 123(R):

	Three Months Ended June 30,				Six Months Ended June 30,
	2008		2007		2008		2007
Risk-free interest rate	2.91	%	4.50	%	2.90	%	4.50	%
Expected dividend yield	None		None		None		None
Expected option term	4.8 years		5.4 years		5.0 years		5.4 years
Volatility	49.9	%	64.1	%	51.1	%	64.1	%

SFAS No. 123(R) requires the application of an estimated forfeiture rate to current period expense to recognize compensation expense only for those awards expected to vest. The Company estimates forfeitures based upon comparable companies’ data and adjusts its estimate of forfeitures if actual forfeitures differ, or are expected to differ from the Company’s estimates. Subsequent changes in estimated forfeitures will be recognized through a cumulative catch-up adjustment in the period of change and will also impact the amount of stock-based compensation expense in future periods.

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Targanta Therapeutics Corporation

(A development-stage company)

Notes to Condensed Consolidated Financial Statements — (continued)

(in thousands, except share and per share amounts)

(Unaudited)

The weighted average grant date fair value of options granted during the three months ended June 30, 2008 and 2007 was $3.53 and $2.32, respectively, and the weighted average grant date fair value of options granted during the six months ended June 30, 2008 and 2007 was $3.92 and $2.32, respectively, based on the assumptions in the Black-Scholes valuation model discussed above.

As of June 30, 2008, there was $7,249 of unrecognized stock-based compensation expense. These costs are expected to be recognized over a weighted average period of 2.95 years.

For the three and six months ended June 30, 2008 and 2007 and the period from May 20, 1997 (date of inception) to June 30, 2008, the total stock-based compensation expense in connection with stock options issued and outstanding amounted to:

	Three Months Ended June 30,				Six Months Ended June 30,				For the Period from May 20, 1997 (date of inception) through June 30, 2008
	2008		2007		2008		2007
Stock-based compensation	$	858	$	1,331	$	1,330	$	1,350	$	5,008

A summary of the status of the Company’s stock option plans at June 30, 2008 and changes during the six months then ended is presented in the table below:

	Shares of Common Stock Attributable to Options		Weighted Average Exercise Price of Options		Weighted Average Remaining Contractual Term (in years)	Aggregate Intrinsic Value
Outstanding at December 31, 2007	2,538,155		$	4.44
Granted	1,256,050			8.32
Exercised	(2,577	)		4.00
Cancelled	(106,237	)		6.46
Outstanding at June 30, 2008	3,685,391		$	5.70	9.08	$	4,049
Vested or expected to vest at June 30, 2008	3,563,339		$	5.69	9.08	$	3,942
Exercisable at June 30, 2008	1,244,347		$	4.65	8.77	$	1,910

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Item 2. Management’s Discussion and Analysis of Financial Condition and Results of Operations

The following discussion contains forward-looking statements, which involve risks and uncertainties. Our actual results could differ materially from those anticipated in these forward-looking statements as a result of various factors, including those set forth under the title “Risk Factors” in our Annual Report on Form 10-K for the fiscal year ended December 31, 2007. The interim financial statements and this Management’s Discussion and Analysis of Financial Condition and Results of Operations should be read in conjunction with the financial statements and notes thereto for the year ended December 31, 2007 and the related Management’s Discussion and Analysis of Financial Condition and Results of Operations, both of which are contained in our Annual Report on Form 10-K filed with Securities and Exchange Commission on March 27, 2008. Except as required by law, we assume no obligation to update these forward-looking statements, whether as a result of new information, future events or otherwise.

Overview

We are a biopharmaceutical company focused on the development and commercialization of innovative antibiotics for serious infections treated or acquired in hospitals and other institutional settings. Our lead product candidate is oritavancin, a novel intravenous antibiotic, for the treatment of serious gram-positive bacterial infections including complicated skin and skin structure infections (“cSSSI”) and bacteremia. In February 2008, we submitted a New Drug Application (“NDA”) to the U.S. Food and Drug Administration (“FDA”) seeking to commercialize oritavancin for the treatment of cSSSI, including infections caused by methicillin-resistantStaphylococcus aureus (“MRSA”). We are hopeful oritavancin will receive U.S. regulatory approval by the end of 2008. In June 2008, we submitted an application for Marketing Authorization Approval (“MAA”) to the European Medicines Agency (“EMEA”) seeking approval to commercialize oritavancin for the treatment of complicated skin and soft tissue infections (“cSSTI”) in Europe. We are hopeful oritavancin will receive European Union regulatory approval in 2009. We plan on commercializing oritavancin through our own direct sales force in the U.S. and in select other countries, and to out-license oritavancin to third parties in other countries as we deem appropriate. In addition, we have completed our planned pre-clinical development of another antiobiotic in osteomyelitis, and we continually evaluate opportunities for potential in-licensing of other antibiotics for the treatment of hospital-based infections.

We acquired worldwide rights to oritavancin from InterMune, Inc. (“InterMune”) in December 2005, and believe that since then we have greatly improved the commercial and economic prospects for the drug by resolving several important issues with the FDA and by substantially lowering the royalty rate that may be payable to Eli Lilly and Company (“Lilly”), the original discoverer of oritavancin. Our strategy is to capitalize on the unique attributes of oritavancin to develop it into a leading therapy worldwide for the treatment of serious gram-positive infections, initially for cSSSI and subsequently for other indications.

We were incorporated as a Delaware corporation on December 6, 2005 and initiated operations through our Québec subsidiary in May 1997 in Montreal, Québec. To date, we have dedicated substantially all of our activities to the research and development of our drug candidates. Accordingly, we are considered to be in the development stage at June 30, 2008, as defined in SFAS No. 7,Accounting and Reporting by Development Stage Enterprises. Our fiscal year ends on December 31 and we operate as one reportable segment. Prior to our acquisition of oritavancin in December 2005, we were focused on early-stage research in the area of antibiotics and the application of our proprietary phage technology.

On October 9, 2007, the Securities and Exchange Commission (“SEC”) declared our Registration Statement on Form S-1, as amended, for our initial public offering of 5.75 million shares of our common stock (Registration No. 333-142842) effective. We sold the shares of common stock in this initial public offering at a price of $10.00 per share. We received net proceeds of approximately $51.1 million after deducting underwriting discounts and commissions and offering expenses of approximately $2.3 million.

We have not generated any revenue to date from product sales and have incurred significant operating losses since our inception in 1997. We incurred net losses of $63.3 million for the year ended December 31, 2007 and $34.7 million for the six months ended June 30, 2008. As of June 30, 2008, we had a deficit accumulated during the development stage of $161.7 million and we expect to incur losses for the foreseeable future.

We expect to incur substantial expenditures in the foreseeable future for the continued development of our product candidates and, if we obtain regulatory approval, for the commercialization of those products. We expect to continue to incur operating losses for at least the next several years and we will need additional financing to support our activities. We will seek to fund our operations through public or private equity or debt financings or other sources, such as collaborations and revenue from the sale of oritavancin, if approved by the FDA. Adequate additional funding may not be available to us on acceptable terms, or at all. Our failure to raise capital as and when needed could have a negative impact on our financial condition and our ability to pursue our business strategies. If adequate funds are not available to us, we may be required to delay, reduce or eliminate research and development programs, reduce or eliminate commercialization efforts, obtain funds through arrangements with collaborators or others on terms unfavorable to us or pursue merger or acquisition strategies.

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Critical Accounting Policies

We believe that several accounting policies are important to understanding our historical and future performance. We refer to these policies as “critical” because these specific areas generally require us to make judgments and estimates about matters that are uncertain at the time we make the estimate, and different estimates – which also would have been reasonable – could have been used, which would have resulted in different financial results. It is important that the discussion of our operating results that follows be read in conjunction with the critical accounting policies disclosed in our Annual Report on Form 10-K for the fiscal year ended December 31, 2007. There have been no changes to these critical accounting policies in the three months ended June 30, 2008.

Results of Operations

Three and six months ended June 30, 2008 compared to three and six months ended June 30, 2007

Revenue. We recorded no revenue during the three and six months ended June 30, 2008 or 2007.

Operating Expenses

The following table summarizes our operating expenses for the three and six months ended June 30, 2008 and 2007:

	Three Months Ended June 30,				Percentage Increase (Decrease)		Six Months Ended June 30,				Percentage Increase (Decrease)
	2008		2007				2008		2007
	(in thousands)						(in thousands)
Operating expenses
Research and development (1)	$	12,859	$	9,405	37	%	$	27,138	$	14,844	83	%
Acquired in-process research and development	$	—	$	—	—	%	$	—	$	9,500	(100	)%
General and administrative (1)	$	4,189	$	2,847	47	%	$	7,807	$	4,782	63	%
(1) Includes stock-based compensation expense of:
Research and development	$	312	$	739			$	569	$	747
General and administrative	$	546	$	592			$	761	$	603

Research and development expense

Research and development expense for the three months ended June 30, 2008 was $12.9 million, compared to $9.4 million for the three months ended June 30, 2007. The $3.5 million increase during the three months ended June 30, 2008 was primarily the result of a $2.3 million increase in contract research expense, which included an increase of $0.9 million in pre-clinical and clinical trials expense resulting from clinical trials conducted and in-vitro clinical database work performed for the oritavancin program, as well as an increase of $1.5 million in third-party product manufacturing, validation and process development expense incurred in preparation for the commercial launch of oritavancin. Additional factors that contributed to the increase in research and development expense were a $0.4 million increase in regulatory filing fees, due to the filing of our MAA with the EMEA and a $0.8 million increase in salaries and benefits expense, mainly due to an increased number of employees working on the oritavancin program. Our research and development expense also increased as a result of a $0.2 million increase in professional services, primarily due to increased consulting and recruiting fees. This was offset by a $0.4 million decrease in stock-based compensation expense as a result of a charge recorded in May 2007 related to the grant of replacement and new options as well as the cancellation of options upon the acceptance of the replacement options.

Research and development expense for the six months ended June 30, 2008 was $27.1 million, compared to $14.8 million for the six months ended June 30, 2007. The $12.3 million increase during the six months ended June 30, 2008 was primarily the result of a $7.9 million increase in contract research expense, which included an increase of $4.8 million in pre-clinical and clinical trials expense resulting from clinical trials conducted and in-vitro clinical database work performed for the oritavancin program, as well as an increase of $3.1 million in third-party product manufacturing, validation and process development expense incurred in preparation

17

for the commercial launch of oritavancin. Additional factors that contributed to the increase in research and development expense were a $1.6 million increase in regulatory filing fees, due to the filing of our NDA with the FDA and our MAA with the EMEA, and a $1.8 million increase in salaries and benefits expense, mainly due to an increased number of employees working on the oritavancin program. Our research and development expense also increased as a result of a $0.7 million increase in professional services, primarily due to increased consulting and recruiting fees. This was offset by a $0.2 million decrease in stock-based compensation expense as a result of a charge recorded in May 2007 related to the grant of replacement and new options as well as the cancellation of options upon the acceptance of the replacement options.

Acquired in-process research and development expense

We did not record any acquired in-process research and development expense for the three months ended June 30, 2008 or 2007.

We did not record any acquired in-process research and development expense for the six months ended June 30, 2008, compared to $9.5 million for the six months ended June 30, 2007. The $9.5 million acquired in-process research and development expense we incurred during the six months ended June 30, 2007 was due to a $2.0 million cash milestone payment to InterMune and a total of $7.5 million of expense related to our achievement of the first milestone under the convertible note we had initially issued to InterMune in December 2005 in connection with our acquisition of oritavancin. This $7.5 million expense reflects the fair value of the shares of our preferred stock and warrants to purchase shares of our preferred stock that we issued to InterMune upon our achievement of this milestone.

General and administrative expense

General and administrative expense for the three months ended June 30, 2008 was $4.2 million, compared to $2.8 million for the three months ended June 30, 2007. The $1.4 million increase during the three months ended June 30, 2008 was primarily the result of a $0.6 million increase in salaries and benefits expense resulting from the hiring of additional administrative staff as we develop our infrastructure to support the commercial launch of oritavancin and a $0.6 million increase in professional and consulting fees, comprised of a $0.3 million increase in consulting fees primarily related to oritavancin pre-launch expenses, investor relations/public relations and administrative support expenses and a $0.3 million increase in insurance, legal fees and patent expenses. An additional factor contributing to the increase in general and administrative expense during the three months ended June 30, 2008 was a $0.1 million increase in expense related to meeting the regulatory requirements associated with being a public company.

General and administrative expense for the six months ended June 30, 2008 was $7.8 million, compared to $4.8 million for the six months ended June 30, 2007. The $3.0 million increase during the six months ended June 30, 2008 was primarily the result of a $1.1 million increase in salaries and benefits expense resulting from the hiring of additional administrative staff as we develop our infrastructure to support the commercial launch of oritavancin; and a $1.5 million increase in professional and consulting fees, comprised of a $0.8 million increase in consulting fees primarily related to oritavancin pre-launch expenses, investor relations/public relations and administrative support expenses and a $0.7 million increase in insurance, legal fees and patent expenses. Additional factors contributing to the increase in general and administrative expense during the six months ended June 30, 2008 were a $0.2 million increase in expense related to meeting the regulatory requirements associated with being a public company and $0.2 million increase in stock-based compensation expense due to the granting of 1.3 million options in the six months ended June 30, 2008.

Interest income

Interest income for the three and six months ended June 30, 2008 was $0.5 million and $1.3 million, respectively, compared to $0.6 million and $1.0 million for the three and six months ended June 30, 2007, respectively. The $0.1 million, or 17%, decrease for the three months ended June 30, 2008 was primarily due to lower market interest rates on higher average cash, cash equivalents and short-term investments balances. The $0.3 million, or 30% increase for the six months ended June 30, 2008 was due to higher average cash, cash equivalents and short-term investments balances. Our cash, cash equivalents and short-term investments balances were higher in 2008 as a result of the $20.0 million of proceeds we received upon our issuance of the term notes to Merrill Lynch Capital and the two other lenders in late September 2007 (the “MLC Term Note”) and the $51.1 million of net proceeds from our October 2007 initial public offering.

Interest expense

Interest expense for the three months ended June 30, 2008 was $0.6 million compared to $(0.3) million for the three months ended June 30, 2007. The increase of $0.9 million, or 300%, for the three months ended June 30, 2008 was primarily due to a $0.6

18

million increase in interest expense related to the MLC Term Note, partially offset by a $0.3 million decrease in interest expense related to the repayment of the loan to our former lender Investissement Québec (“IQ”) by our Québec subsidiary. Additionally, in the three months ended June 30, 2007, we reversed $0.5 million of interest expense related to an error in the calculation of the fair value of the warrants issued to IQ due to the use of a contractual term of 8.4 years rather than 2.2 years in the Black-Scholes option pricing model. The reduction in the contractual term resulted in $0.5 million less of interest expense in the three months ended June 30, 2007.

Interest expense for the six months ended June 30, 2008 was $1.2 million compared to $1.9 million for the six months ended June 30, 2007. The decrease of $0.7 million, or 37%, for the six months ended June 30, 2008 was primarily due to a $2.0 million decrease in interest expense and $0.3 million decrease in amortization of deferred financing costs resulting from the January 2007 conversion of the outstanding convertible notes and convertible debentures into shares of our preferred stock and the repayment of the loan to IQ by our Québec subsidiary; partially offset by a $1.2 million increase in interest expense related to the MLC Term Note in the six months ended June 30, 2008 and a reduction of interest expense in the six months ended June 30, 2007 of $0.4 million related to the change in the fair value of the IQ warrant.

Foreign Exchange gain (loss)

Foreign exchange gain for the three months ended June 30, 2008 was $5,000, compared to a foreign exchange loss of $789,000 in the three months ended June 30, 2007. Foreign exchange loss for the six months ended June 30, 2008 was $14,000, compared to $853,000 in the six months ended June 30, 2007. The change in the foreign exchange loss of $794,000, or 101%, and $839,000, or 98%, in the three and six months ended June 30, 2008, respectively, resulted from the strengthening of the Canadian dollar as the foreign exchange gain (loss) is primarily a result of the translation adjustments resulting from the financial statements of our Canadian subsidiaries.

Income tax benefit

Income tax benefit for the three and six months ended June 30, 2008 was $74,000 and $140,000, respectively, compared to an income tax benefit of $83,000 and $54,000 for the three and six months ended June 30, 2007, respectively. The $9,000, or 11%, decrease in income tax benefit for the three months ended June 30, 2008 primarily resulted from the strengthening of the Canadian dollar. The $86,000 increase in income tax benefit for the six months ended June 30, 2008 primarily resulted from no longer recording any Canadian Part VI.I income tax expense on the accumulated dividends related to our Series B Redeemable Convertible Preferred Stock as a result of the January 2007 payment of the accrued dividend (and the associated termination of the cumulative dividend) on those shares.

Liquidity and Capital Resources

On October 9, 2007, our Registration Statement on Form S-1, as amended, for our initial public offering of 5.75 million shares of our common stock was declared effective by the SEC. On October 15, 2007, we sold these 5.75 million registered shares at a price of $10.00 per share. We received net proceeds of approximately $51.1 million from the offering after deducting underwriting discounts and commissions and offering expenses of approximately $2.3 million.

Prior to our October 9, 2007 initial public offering, we financed our operations primarily through the sale of preferred stock and common stock, debt financings, interest earned on investments and investment tax credits. Prior to our initial public offering, we had received aggregate gross proceeds of $125.8 million from financings, of which $70.4 million was from the issuance of preferred stock, $2.7 million was from the issuance of common stock and $52.7 million was from debt financings. Our cash, cash equivalents, short-term investments and restricted cash include amounts held in money market accounts, overnight investment accounts, guaranteed investment certificates, certificates of deposit, commercial paper, asset backed securities, United States treasury bills, debt obligations of government agencies and corporate obligations, stated at cost plus accrued interest, which approximates fair market value. We invest cash in excess of immediate requirements in accordance with our investment policy, which is focused primarily on the preservation of capital, fulfillment of liquidity needs, fiduciary control of cash and investments and the maximization of income from our investments without assuming significant risk. At June 30, 2008, we did not own any mortgage backed securities or auction rate securities.

As of June 30, 2008, we had cash, cash equivalents and short-term investments of approximately $58.7 million. We intend to use our cash to fund internal and external costs related to regulatory filings in Europe; to fund clinical trials for oritavancin in cSSSI using a single administration, including our Phase 2 clinical trial entitled “Single or Infrequent Doses for the Treatment of Complicated Skin and Skin Structure Infections,” or SIMPLIFI, which completed enrollment in May 2008; and to continue the clinical development of oritavancin for other indications such as bacteremia; in anticipation of regulatory approval, to fund commercial launch related expenses for oritavancin including manufacturing, marketing, and sales; to make regularly scheduled payments on our existing debt facilities, namely the MLC Term Note; and to apply the remaining funds for general corporate purposes and the potential acquisition of, or investment in, technologies, products, or companies that complement our business.

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The amounts and timing of our actual expenditures will depend upon numerous factors, including whether we obtain FDA and foreign regulatory approvals for oritavancin and, if so, the timing of such approval; the success of the commercial launch of oritavancin if approved by the FDA; our cash flows from operations; any potential acquisitions of or investments in technologies, products or companies; and the anticipated growth of our business.

We expect our existing resources to be sufficient to fund our planned operations into the third quarter of 2009.

Cash Flows

The following table summarizes our net increase in cash and cash equivalents for the six months ended June 30, 2008 and 2007:

	Six Months Ended June 30,
	2008			2007
	(in thousands)
Net cash provided by (used in):
Operating activities	$	(28,493	)	$	(16,924	)
Investing activities		34,113			(15,512	)
Financing activities		(2,212	)		54,846
Net increase in cash and cash equivalents	$	3,408		$	22,410

Net cash used in operating activities. Net cash used in operating activities was $28.5 million and $16.9 million for the six months ended June 30, 2008 and 2007, respectively, and primarily reflects our net loss for those periods. The increase in net cash used in the six months ended June 30, 2008 compared to the six months ended June 30, 2007 was due primarily to a $7.5 million decrease in non-cash acquired in-process research and development expense; a $1.3 million decrease in non-cash interest expense; a $0.3 million decrease in amortization of deferred financing costs expense; a $1.1 million decrease in unrealized foreign exchange loss and a $3.9 million increase in net loss; offset by a $2.4 million increase in net changes in working capital items relating to operations.

Net cash provided by (used in) investing activities. Net cash provided by investing activities was $34.1 million for the six months ended June 30, 2008 and net cash used in investing activities was $15.5 million in the six months ended June 30, 2007. Investing activities consist primarily of purchases and sales of short-term securities and capital purchases. The increase in cash provided by investing activities in the six months ended June 30, 2008 compared to the six months ended June 30, 2007 was primarily due to a $47.3 million increase in the proceeds from the sales and maturities of short-term investments and a decrease of $2.0 million of cash used to purchase short-term investments.

Net cash (used in) provided by financing activities. Net cash used in financing activities was $2.2 million for the six months ended June 30, 2008 and net cash provided by financing activities was $54.8 million for the six months ended June 30, 2007. The increase in net cash used in the six months ended June 30, 2008 compared to the six months ended June 30, 2007 was primarily due to a decrease in proceeds from the issuance of preferred stock and warrants of $57.8 million; an increase of payments on long-term debt of $2.2 million; offset by a decrease in payments on convertible notes of $2.2 million.

Contractual obligations

During the fiscal quarter ended June 30, 2008, we did not incur any additional obligations that materially change the disclosure of our contractual obligations in our Annual Report on Form 10-K for the fiscal year ended December 31, 2007.

Off-balance sheet arrangements

We do not have any relationships with unconsolidated entities or financial partnerships, such as entities often referred to as structured finance or special purpose entities, that would have been established for the purpose of facilitating off-balance sheet arrangements (as that term is defined in Item 303(a)(4)(ii) of Regulation S-K) or other contractually narrow or limited purposes. As such, we are not exposed to any financing, liquidity, market or credit risk that could arise if we had engaged in those types of relationships.

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Recently issued accounting pronouncements

In December, 2007, EITF 07-01, Accounting for Collaborative Arrangements Related to the Development and Commercialization of Intellectual Property (“EITF 07-01”), was issued. EITF 07-01 prescribes the accounting for collaborations, requiring that, when certain characteristics exist in collaboration relationships, certain transactions between collaborators be recorded within expenses in the income statement on either a gross or net basis. EITF 07-01 is effective for all of our collaborations existing after January 1, 2009. We currently have no collaborations that are impacted by EITF 07-01. We will evaluate any future collaborations under this guidance, as appropriate.

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Item 3. Quantitative and Qualitative Disclosures about Market Risk

Interest Rate Risk

We are exposed to market risk related to changes in interest rates. As of June 30, 2008, we had cash, cash equivalents and short-term investments of approximately $58.7 million. In accordance with our investment policy, this amount is invested in a mix of cash and highly liquid short-term investments. The goals of our investment policy are preservation of capital, fulfillment of liquidity needs and fiduciary control of cash and investments. We also seek to maximize income from our investments without assuming significant risk.

Our primary exposure to market risk is interest income sensitivity, which is affected by changes in the general level of interest rates, particularly because our investments are in short-term marketable securities. Due to the short-term duration of our investment portfolio and the low risk profile of our investments, an immediate 10% change in interest rates would not have a material effect on the fair market value of our portfolio. Accordingly, we would not expect our operating results or cash flows to be affected to any significant degree by the effect of a sudden change in market interest rates on our securities portfolio.

As of June 30, 2008, our outstanding MLC Term Note has a fixed interest rate and therefore has minimal exposure to changes in interest rates.

Foreign Currency Risk

Most of our transactions are conducted in U.S. dollars, although we do have some development and clinical trial agreements with vendors located outside the U.S. Transactions under certain of these agreements are conducted in U.S. dollars while others are transacted in the applicable local currency. The expenses and capital spending of our Canadian subsidiaries are transacted in Canadian dollars and subject to foreign exchange rate risk. Our foreign currency transactions are translated into U.S. dollars at prevailing rates. Gains or losses resulting from foreign currency transactions are included in current period income or loss as incurred. All material transactions are denominated in U.S. dollars and we have not entered into any material transactions that are denominated in foreign currencies. As a result, we do not believe that an immediate 10% change in the exchange rate applicable to our international business dealings would have a material impact on our results of operations or cash flows.

Effects of Inflation

We do not believe that inflation and changing prices over the three and six months ended June 30, 2008 and 2007 had a significant impact on our results of operations.

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Item 4. Controls and Procedures

Evaluation of Disclosure Controls and Procedures

As required by Rule 13a–15(b) of the Securities and Exchange Act of 1934, as amended (the “1934 Act”), our management, including the principal executive officer and the principal financial officer, conducted an evaluation as of the end of the period covered by this Quarterly Report on Form 10-Q of the effectiveness of the design and operation of our disclosure controls and procedures. Based on that evaluation, our principal executive officer and principal financial officer concluded that our disclosure controls and procedures are effective at a reasonable assurance level in ensuring that information required to be disclosed by us in the reports that we file or submit under the 1934 Act is recorded, processed, summarized and reported within the time periods specified in the SEC’s rules and forms. Disclosure controls and procedures include, without limitation, controls and procedures designed to ensure that information required to be disclosed by us in the reports we file under the 1934 Act is accumulated and communicated to our management, including our principal executive officer and principal financial officer, as appropriate to allow timely decisions regarding required disclosure.

Changes in Internal Control

As required by Rule 13a-15(d) of the 1934 Act, our management, including the principal executive officer and the principal financial officer, conducted an evaluation of the internal control over financial reporting to determine whether any changes occurred during the period covered by this Quarterly Report on Form 10-Q that have materially affected, or are reasonably likely to materially affect, our internal control over financial reporting. Based on that evaluation, the principal executive officer and principal financial officer concluded no such changes during the fiscal quarter covered by this Quarterly Report on Form 10-Q materially affected, or were reasonably likely to materially affect, our internal control over financial reporting.

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PART II. OTHER INFORMATION

Item 1. Legal Proceedings

We currently are not a party to any material legal proceedings.

Item 1A. Risk Factors

In addition to the other information set forth in this Quarterly Report on Form 10-Q, you should carefully consider the factors discussed under the title “Risk Factors” in our Annual Report on Form 10-K for the fiscal year ended December 31, 2007 and our Quarterly Report on Form 10-Q for the quarterly period ended March 31, 2008, which risks could materially affect our business, financial condition and/or future results. The risks described in our Annual Report on Form 10-K are not the only risks facing our Company. Additional risks and uncertainties not currently known to us or that we currently deem to be immaterial also may materially adversely affect our business, financial condition and/or operating results.

Item 2. Unregistered Sales of Equity Securities and Use of Proceeds.

Unregistered Sales of Equity Securities

None.

Use of Proceeds

On October 9, 2007, our Registration Statement on Form S-1, as amended (File No. 333-142842), relating to the initial public offering was declared effective by the SEC. On October 15, 2007, we closed the sale of 5.75 million shares of common stock in the initial public offering for net proceeds to us of approximately $51.1 million. As of June 30, 2008, $51.1 million of the net proceeds remained available and were primarily invested in highly liquid short-term investments, including money market accounts, overnight investment accounts, certificates of deposit, commercial paper, corporate bonds, asset backed securities, United States treasury bills and debt obligations of various government agencies, pending their use to fund our operations and expansion. There has been no material change in our planned use of proceeds from the initial public offering from that described in our Annual Report on Form 10-K for the fiscal year ended December 31, 2007.

Item 3. Defaults Upon Senior Securities

None.

Item 4. Submission of Matters to a Vote of Security Holders

We held our annual meeting of stockholders on June 2, 2008. The following proposals were voted upon at the meeting.

(a) A proposal to elect two Class I directors, each to serve a term of three years:

	Number of Votes
	For	Withheld	For All Except
Mark W. Leuchtenberger	19,949,296	—	—
William W. Crouse	19,949,296	—	—

Each nominee received a plurality of the votes cast and, therefore, was duly re-elected as a director of the Company. The terms of office of the other directors: Garen Bohlin, Jeffrey Courtney, Eric M. Gordon, Ph.D., Dilip J. Mehta, M.D., Ph.D., and Jay Venkatesan, M.D., continued after the meeting.

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(b) A proposal to ratify the selection of Ernst & Young LLP as the Company’s independent registered public accounting firm for the fiscal year ending December 31, 2008:

Number of Votes For	Number of Votes Against	Number of Votes Abstaining	Number of Broker Non-Votes
19,941,792	7,504	—	—

The number of votes cast in favor of the proposal exceeded the number of votes cast against the proposal and, therefore, the proposal was adopted.

Item 5. Other Information

None.

Item 6. Exhibits

The Exhibits listed in the Exhibit Index immediately preceding the Exhibits are filed as a part of this Quarterly Report on Form 10-Q.

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SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, as amended, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.

	TARGANTA THERAPEUTICS CORPORATION
Date: August 7, 2008	By:	/s/ Mark W. Leuchtenberger
		Mark W. Leuchtenberger
		Director, President and Chief Executive Officer (principal executive officer)
Date: August 7, 2008	By:	/s/ George A. Eldridge
		George A. Eldridge
		Senior Vice President, Finance and Administration, Chief Financial Officer, Treasurer and Assistant Secretary (principal accounting and financial officer)

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EXHIBIT INDEX

Exhibit No:	Description
31.1	Certification of Chief Executive Officer pursuant to Rules 13a-14 or 15d-14 of the 1934 Act
31.2	Certification of Chief Financial Officer pursuant to Rules 13a-14 or 15d-14 of the 1934 Act
32.1	Certification of Chief Executive Officer pursuant to Rules 13a-14(b) or 15d-14(b) of the 1934 Act and 18 U.S.C. Section 1350
32.2	Certification of Chief Financial Officer pursuant to Rules 13a-14(b) or 15d-14(b) of the 1934 Act and 18 U.S.C. Section 1350

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