Kubota Pharmaceutical (KBBTF) 8-K Amendments to Articles of Incorporation or Bylaws

Exhibit 3.1

Amended text of Section 2.1of the Bylaws of Acucela Inc.:

2.1 Annual Meeting

The annual meeting of the shareholders to elect Directors and transact such other business as may properly come before the meeting shall be held on a date not more than 180 days after the end of the corporation’s fiscal year, such date

and time to be determined by the Board.