DiaMedica Therapeutics (DMAC) 10-Q 10 Aug 22 2022 Q2 Quarterly report Financial data

Document And Entity Information

Document And Entity Information - shares	6 Months Ended
	Jun. 30, 2022	Aug. 09, 2022
Document Information [Line Items]
Entity Central Index Key	0001401040
Amendment Flag	false
Current Fiscal Year End Date	--12-31
Document Fiscal Year Focus	2022
Document Fiscal Period Focus	Q2
Document Type	10-Q
Document Quarterly Report	true
Document Period End Date	Jun. 30, 2022
Document Transition Report	false
Entity File Number	001-36291
Entity Registrant Name	DIAMEDICA THERAPEUTICS INC.
Entity Incorporation, State or Country Code	A1
Entity Address, Address Line One	Two Carlson Parkway, Suite 260
Entity Address, City or Town	Minneapolis
Entity Address, State or Province	MN
Entity Address, Postal Zip Code	55447
City Area Code	763
Local Phone Number	312-6755
Title of 12(b) Security	Voting common shares, no par value per share
Trading Symbol	DMAC
Security Exchange Name	NASDAQ
Entity Current Reporting Status	Yes
Entity Interactive Data Current	Yes
Entity Filer Category	Non-accelerated Filer
Entity Small Business	true
Entity Emerging Growth Company	true
Entity Ex Transition Period	true
Entity Shell Company	false
Entity Common Stock, Shares Outstanding		26,443,067

Condensed Consolidated Balance

Condensed Consolidated Balance Sheets (Unaudited) - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Current assets:
Cash and cash equivalents	$ 3,062	$ 4,707
Marketable securities	35,381	40,405
Amounts receivable	88	130
Deposits	108	113
Prepaid expenses and other assets	534	84
Total current assets	39,173	45,439
Non-current assets:
Property and equipment, net	74	70
Operating lease right-of-use asset	11	42
Total non-current assets	85	112
Total assets	39,258	45,551
Current liabilities:
Accounts payable	624	509
Accrued liabilities	894	966
Finance lease obligation	7	4
Operating lease obligation	11	45
Total current liabilities	1,536	1,524
Non-current liabilities:
Finance lease obligation, non-current	7	3
Total non-current liabilities	7	3
Shareholders’ equity:
Common shares, no par value; unlimited authorized; 26,443,067 shares issued and outstanding as of June 30, 2022 and December 31, 2021	0	0
Paid-in capital	127,249	126,576
Accumulated other comprehensive loss	(167)	(51)
Accumulated deficit	(89,367)	(82,501)
Total shareholders’ equity	37,715	44,024
Total liabilities and shareholders’ equity	$ 39,258	$ 45,551

Condensed Consolidated Balanc_2

Condensed Consolidated Balance Sheets (Unaudited)-parentheticals (Parentheticals) - $ / shares $ / shares in Thousands	6 Months Ended	12 Months Ended
	Jun. 30, 2022	Dec. 31, 2021
Common shares, par value (in dollars per share)	$ 0	$ 0
Common shares, authorized	Unlimited	Unlimited
Common Stock, Shares, Issued (in shares)	26,443,067	26,443,067
Common Stock, Shares, Outstanding, Ending Balance (in shares)	26,443,067	26,443,067

Condensed Consolidated Statemen

Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Operating expenses:
Research and development	$ 1,955	$ 2,156	$ 3,929	$ 4,562
General and administrative	1,409	1,209	2,971	2,422
Operating loss	(3,364)	(3,365)	(6,900)	(6,984)
Other income:
Other income, net	13	98	48	102
Loss before income tax expense	(3,351)	(3,267)	(6,852)	(6,882)
Income tax expense	(7)	(7)	(14)	(14)
Net loss	(3,358)	(3,274)	(6,866)	(6,896)
Other comprehensive income (loss)
Unrealized gain (loss) on marketable securities	(60)	1	(116)	(1)
Net loss and comprehensive loss	$ (3,418)	$ (3,273)	$ (6,982)	$ (6,897)
Basic and diluted net loss per share (in dollars per share)	$ (0.13)	$ (0.17)	$ (0.26)	$ (0.37)
Weighted average shares outstanding – basic and diluted (in shares)	26,443,067	18,786,157	26,443,067	18,776,461

Condensed Consolidated Statem_2

Condensed Consolidated Statements of Shareholders' Equity (Unaudited) - USD ($)	Common Stock [Member]	Additional Paid-in Capital [Member]	AOCI Attributable to Parent [Member]	Retained Earnings [Member]	Total
Balance (in shares) at Dec. 31, 2020	18,746,157
Balance at Dec. 31, 2020		$ 94,925,000	$ (2,000)	$ (68,909,000)	$ 26,014,000
Share-based compensation expense		511,000	0	0	511,000
Unrealized gain (loss) on marketable securities		0	(2,000)	0	(2,000)
Net loss		0	0	(3,622,000)	(3,622,000)
Balance (in shares) at Mar. 31, 2021	18,786,157
Balance at Mar. 31, 2021		95,680,000	(4,000)	(72,531,000)	23,145,000
Exercise of common stock options (in shares)	40,000
Exercise of common stock options		244,000	0	0	244,000
Balance (in shares) at Dec. 31, 2020	18,746,157
Balance at Dec. 31, 2020		94,925,000	(2,000)	(68,909,000)	26,014,000
Unrealized gain (loss) on marketable securities					(1,000)
Net loss					(6,896,000)
Balance (in shares) at Jun. 30, 2021	18,786,157
Balance at Jun. 30, 2021		96,126,000	(3,000)	(75,805,000)	20,318,000
Exercise of common stock options (in shares)	40,000
Balance (in shares) at Mar. 31, 2021	18,786,157
Balance at Mar. 31, 2021		95,680,000	(4,000)	(72,531,000)	23,145,000
Share-based compensation expense		446,000	0	0	446,000
Unrealized gain (loss) on marketable securities		0	1,000	0	1,000
Net loss		0	0	(3,274,000)	(3,274,000)
Balance (in shares) at Jun. 30, 2021	18,786,157
Balance at Jun. 30, 2021		96,126,000	(3,000)	(75,805,000)	20,318,000
Balance (in shares) at Dec. 31, 2021	26,443,067
Balance at Dec. 31, 2021		126,576,000	(51,000)	(82,501,000)	44,024,000
Share-based compensation expense		308,000	0	0	308,000
Unrealized gain (loss) on marketable securities		0	(56,000)	0	(56,000)
Net loss		0	0	(3,508,000)	(3,508,000)
Balance (in shares) at Mar. 31, 2022	26,443,067
Balance at Mar. 31, 2022		126,884,000	(107,000)	(86,009,000)	40,768,000
Balance (in shares) at Dec. 31, 2021	26,443,067
Balance at Dec. 31, 2021		126,576,000	(51,000)	(82,501,000)	44,024,000
Unrealized gain (loss) on marketable securities					(116,000)
Net loss					(6,866,000)
Balance (in shares) at Jun. 30, 2022	26,443,067
Balance at Jun. 30, 2022		127,249,000	(167,000)	(89,367,000)	$ 37,715,000
Exercise of common stock options (in shares)					0
Exercise of common stock options	$ 132,000
Balance (in shares) at Mar. 31, 2022	26,443,067
Balance at Mar. 31, 2022		126,884,000	(107,000)	(86,009,000)	$ 40,768,000
Share-based compensation expense		365,000	0	0	365,000
Unrealized gain (loss) on marketable securities		0	(60,000)	0	(60,000)
Net loss		0	0	(3,358,000)	(3,358,000)
Balance (in shares) at Jun. 30, 2022	26,443,067
Balance at Jun. 30, 2022		$ 127,249,000	$ (167,000)	$ (89,367,000)	$ 37,715,000

Condensed Consolidated Statem_3

Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
Cash flows from operating activities:
Net loss	$ (6,866,000)	$ (6,896,000)
Adjustments to reconcile net loss to net cash used in operating activities:
Share-based compensation	673,000	957,000
Amortization of premium on marketable securities	160,000	38,000
Non-cash lease expense	31,000	28,000
Depreciation	12,000	12,000
Changes in operating assets and liabilities:
Amounts receivable	42,000	324,000
Deposits	5,000	6,000
Prepaid expenses and other assets	(450,000)	(250,000)
Accounts payable	115,000	(860,000)
Accrued liabilities	(106,000)	239,000
Net cash used in operating activities	(6,384,000)	(6,402,000)
Cash flows from investing activities:
Purchase of marketable securities	(27,510,000)	(25,244,000)
Maturities of marketable securities	32,258,000	26,235,000
Purchases of property and equipment	(6,000)	(13,000)
Proceeds from disposition of property and equipment	0	2,000
Net cash provided by investing activities	4,742,000	980,000
Cash flows from financing activities:
Proceeds from the exercise of stock options	0	244,000
Principal payments on finance lease obligations	(3,000)	(3,000)
Net cash provided by (used in) financing activities	(3,000)	241,000
Net decrease in cash and cash equivalents	(1,645,000)	(5,181,000)
Cash and cash equivalents at beginning of period	4,707,000	7,409,000
Cash and cash equivalents at end of period	3,062,000	2,228,000
Supplemental disclosure of non-cash transactions:
Assets acquired under financing lease	$ 10,000	$ 0

Note 1 - Business

Note 1 - Business	6 Months Ended
	Jun. 30, 2022
Notes to Financial Statements
Business Description and Basis of Presentation [Text Block]	1. Business DiaMedica Therapeutics Inc. and its wholly-owned subsidiaries, DiaMedica USA, Inc. and DiaMedica Australia Pty Ltd. (collectively we, us, our, DiaMedica and the Company), exists for the primary purpose of advancing the clinical and commercial development of our proprietary recombinant KLK1 protein, DM199, for the treatment of neurological and kidney diseases. Currently, our primary focus is on developing DM199, a proprietary recombinant form of the human tissue kallikrein-1 (KLK1) protein for the treatment of acute ischemic stroke (AIS) and chronic kidney disease (CKD). Our parent company is governed under British Columbia’s Business Corporations Act, and our common shares are publicly traded on The Nasdaq Capital Market under the symbol “DMAC.”

Note 2 - Risks and Uncertaintie

Note 2 - Risks and Uncertainties	6 Months Ended
	Jun. 30, 2022
Notes to Financial Statements
Unusual Risks and Uncertainties [Table Text Block]	2. Risks and Uncertainties DiaMedica operates in a highly regulated and competitive environment. The development, manufacturing and marketing of pharmaceutical products require approval from, and are subject to ongoing oversight by, the Food and Drug Administration (FDA) in the United States, the European Medicines Agency (EMA) in the European Union and comparable agencies in other countries. We are in the clinical stage of development of our initial product candidate, DM199, for the treatment of AIS and CKD. The Company has not completed the development of any product candidate and does not generate any revenues from the commercial sale of any product candidate. DM199 requires significant additional clinical testing and investment prior to seeking marketing approval and is not expected to be commercially available for at least three to four years, if at all. On July 6, 2022, the Company announced that the FDA placed a clinical hold on the Company’s Phase 2/3 ReMEDy2 trial, which is an adaptive design, randomized, double-blind, placebo-controlled trial studying the use of DM199 to treat AIS patients. The clinical hold was issued following the Company voluntarily pausing patient enrollment in the trial to investigate three unexpected instances of clinically significant hypotension (low blood pressure) occurring shortly after initiation of the intravenous (IV) dose of DM199. The blood pressure levels of the three patients recovered back to their baseline blood pressure within minutes after IV infusion was stopped and the patients suffered no further adverse events. The Company may not enroll any additional patients in the ReMEDy2 trial until the Company provides the FDA with the Company’s analysis of the events leading to or causing the hypotension, its protocol modifications to address the mitigation of these events, its rationale and supporting data for the protocol modifications, and the FDA notifies the Company that it may resume enrollment in the clinical trial. Based on information received to date, the Company believes that the use of IV administration bags made from a different type of plastic in the ReMEDy2 study is responsible for the unexpected hypotension and that a proportionate reduction in the DM199 dose level for the initial IV dose will effectively mitigate the hypotension issue in future ReMEDy2 patients. The Company plans to submit a revised ReMEDy2 trial protocol with the supporting rationale and data to the FDA in September 2022. However, there can be no assurance that our belief as to the cause of the hypotension events or our response to prevent future events is correct, or that we will be able to fully respond to the FDA’s questions sufficiently for the FDA to lift the clinical hold. It is also possible that the FDA may subsequently make additional requests that we would need to fulfill prior to the lifting of the clinical hold, such as requiring us to complete additional clinical trials or imposing stricter approval conditions than we currently expect for our DM199 product candidate. Prior to voluntarily halting enrollment, our Phase 2/3 ReMEDy2 trial has been adversely impacted by the COVID-19 pandemic and other factors. Specifically, we have experienced, and when we resume enrollment we may continue to experience, slower than expected site activations and enrollment in our ReMEDy2 trial. We believe this may be due to a number of factors, including the reduction or suspension of research activities at our current and targeted clinical study sites, as well as staffing shortages, due to COVID-19 and concerns managing logistics and protocol compliance for patients discharged from the hospital to an intermediate care facility during the three-week treatment period. While we are encouraged that COVID-19 related hospitalizations are down compared to prior periods and while we have taken and will continue to take certain actions to assist study sites in overcoming these issues, no assurances can be provided as to if and when these issues will resolve. The Company’s future success is dependent upon the success of its development efforts, its ability to demonstrate clinical progress for its DM199 product candidate in the United States or other markets, its ability to obtain required governmental approvals of its product candidate, its ability to license or market and sell its DM199 product candidate and its ability to obtain additional financing to fund these efforts. As of June 30, 2022, we have incurred losses of $89.4 million since our inception in 2000. For the six months ended June 30, 2022, we incurred a net loss of $6.9 million and negative cash flows from operating activities of $6.4 million. We expect to continue to incur operating losses until such time as any future product sales, royalty payments, licensing fees, and/or milestone payments generate revenue sufficient to fund our continuing operations. For the foreseeable future, we expect to incur significant operating losses as we continue the development and clinical studies of, and to seek regulatory approval for, our DM199 product candidate. As of June 30, 2022, DiaMedica had combined cash, cash equivalents and marketable securities of $38.4 million, working capital of $37.6 million and shareholders’ equity of $37.7 million. Our principal source of cash has been net proceeds from the issuance of equity securities. Although the Company has previously been successful in obtaining financing through equity securities offerings, there is no assurance that we will be able to do so in the future. This is particularly true if we are unable to resolve the clinical hold on our ReMEDy2 trial, if our clinical data is not positive or if economic and market conditions do not improve or further deteriorate. We expect that we will need substantial additional capital to further our research and development activities, complete the required clinical studies, regulatory activities and manufacturing development for our product candidate, DM199, or any future product candidates, to a point where they may be licensed or commercially sold. We expect our current cash, cash equivalents and marketable securities to fund our planned operations for at least the next twelve months from the date of issuance of these condensed consolidated financial statements. The amount and timing of our future funding requirements will depend on many factors, including the timing and results of our ongoing development efforts, including the duration of the current clinical hold, the rate of site activation and enrollment in our clinical studies, the potential expansion of our current development programs, potential new development programs, the effects of the COVID-19 pandemic, staffing shortages and other factors on our clinical trials and our operating expenses. We may require significant additional funds earlier than we currently expect and there is no assurance that we will not need or seek additional funding prior to such time, especially if market conditions for raising capital are favorable.

Note 3 - Summary of Significant

Note 3 - Summary of Significant Accounting Policies	6 Months Ended
	Jun. 30, 2022
Notes to Financial Statements
Liquidity and Management Plans [Text Block]	3. Summary of Significant Accounting Policies Interim financial statements We have prepared the accompanying condensed consolidated financial statements in accordance with accounting principles generally accepted in the United States (US GAAP) for interim financial information and with the instructions to Form 10-Q and Regulation S-X of the Securities and Exchange Commission (SEC). Accordingly, they do not include all of the information and footnotes required by US GAAP for complete financial statements. These condensed consolidated financial statements reflect all adjustments consisting of normal recurring accruals which, in the opinion of management, are necessary to present fairly our consolidated financial position, consolidated results of operations, consolidated statement of shareholders’ equity and consolidated cash flows for the periods and as of the dates presented. Our fiscal year ends on December 31. The condensed consolidated balance sheet as of December 31, 2021 was derived from our audited consolidated financial statements. Certain prior year amounts have been reclassified to conform to the current year presentation. These condensed consolidated financial statements should be read in conjunction with our annual consolidated financial statements and the notes thereto. The nature of our business is such that the results of any interim period may not be indicative of the results to be expected for the entire year. Cash and cash equivalents The Company considers all bank deposits, including money market funds, and other investments, purchased with an original maturity to the Company of three months or less, to be cash and cash equivalents. The carrying amount of our cash equivalents approximates fair value due to the short maturity of the investments. Concentration of credit risk Financial instruments that potentially expose the Company to concentration of credit risk consist primarily of cash, cash equivalents and marketable securities. The Company maintains its cash balances primarily with two financial institutions. These balances generally exceed federally insured limits. The Company has not experienced any losses in such accounts and believes it is not exposed to any significant credit risk in cash and cash equivalents. The Company believes that the credit risk related to marketable securities is limited due to the adherence to an investment policy focused on the preservation of principal. Marketable securities The Company’s marketable securities typically consist of obligations of the United States government and its agencies and investment grade corporate obligations, which are classified as available-for-sale and included in current assets as they are intended to fund current operations. Securities are valued based on market prices for similar assets using third party certified pricing sources. Available-for-sale securities are carried at fair value with unrealized gains and losses reported as a component of shareholders’ equity in accumulated other comprehensive loss. The amortized cost of debt securities is adjusted for amortization of premiums and accretion of discounts to maturity. Such amortization or accretion is included in interest income. Realized gains and losses, if any, are calculated on the specific identification method and are included in other income in the condensed consolidated statements of operations. Available-for-sale securities are reviewed for possible impairment at least quarterly, or more frequently if circumstances arise that may indicate impairment. When the fair value of the securities declines below the amortized cost basis, impairment is indicated and it must be determined whether it is other than temporary. Impairment is considered to be other than temporary if the Company: (i) intends to sell the security, (ii) will more likely than not be forced to sell the security before recovering its cost, or (iii) does not expect to recover the security’s amortized cost basis. If the decline in fair value is considered other than temporary, the cost basis of the security is adjusted to its fair market value and the realized loss is reported in earnings. Subsequent increases or decreases in fair value are reported as a component of shareholders’ equity in accumulated other comprehensive loss. There were no other-than-temporary unrealized losses as of June 30, 2022. Fair value measurements Under the authoritative guidance for fair value measurements, fair value is defined as the exit price, or the amount that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants as of the measurement date. The authoritative guidance also establishes a hierarchy for inputs used in measuring fair value that maximizes the use of observable inputs and minimizes the use of unobservable inputs by requiring that the most observable inputs be used when available. Observable inputs are inputs market participants would use in valuing the asset or liability developed based on market data obtained from sources independent of the Company. Unobservable inputs are inputs that reflect the Company’s assumptions about the factors market participants would use in valuing the asset or liability developed based upon the best information available in the circumstances. The categorization of financial assets and financial liabilities within the valuation hierarchy is based upon the lowest level of input that is significant to the fair value measurement. The hierarchy is broken down into three levels defined as follows: Level 1 Inputs Level 2 Inputs Level 3 Inputs As of June 30, 2022, the Company believes that the carrying amounts of its other financial instruments, including amounts receivable, accounts payable and accrued liabilities, approximate their fair value due to the short-term maturities of these instruments. See Note 4, titled “ Marketable Securities Patent costs Costs associated with applying for, prosecuting and maintaining patents are expensed as incurred given the uncertainty of patent approval and, if approved, the resulting probable future economic benefit to the Company. Patent-related costs, consisting primarily of legal expenses and filing/maintenance fees, are included in general and administrative costs and were $90,000 and $68,000 for the six months ended June 30, 2022 and 2021, respectively.

Note 4 - Marketable Securities

Note 4 - Marketable Securities	6 Months Ended
	Jun. 30, 2022
Notes to Financial Statements
Investments in Debt and Marketable Equity Securities (and Certain Trading Assets) Disclosure [Text Block]	4. Marketable Securities The available-for-sale marketable securities are primarily comprised of investments in commercial paper, corporate bonds and government securities and consist of the following, measured at fair value on a recurring basis (in thousands): Fair Value Measurements Using Inputs Considered as of: June 30, 2022 December 31, 2021 Total Level 1 Level 2 Level 3 Total Level 1 Level 2 Level 3 Government securities $ 24,286 $ — $ 24,286 $ — $ 29,421 $ — $ 29,421 $ — Commercial paper and corporate bonds 11,095 — 11,095 — 10,984 — 10,984 — Total $ 35,381 $ — $ 35,381 $ — $ 40,405 $ — $ 40,405 $ — Accrued interest receivable on available-for-sale securities is included in amounts receivable and was $88,000 and $130,000 as of June 30, 2022 and December 31, 2021, respectively. There were no transfers of assets between Level 1 and Level 2 of the fair value measurement hierarchy during the six months ended June 30, 2022. Under the terms of the Company’s investment policy, purchases of marketable securities are limited to investment grade governmental and corporate obligations and bank certificates of deposit with a primary objective of principal preservation. Maturities of individual securities are less than one year and the amortized cost of all securities approximated fair value as of June 30, 2022 and December 31, 2021.

Note 5 - Amounts Receivable

Note 5 - Amounts Receivable	6 Months Ended
	Jun. 30, 2022
Notes to Financial Statements
Loans, Notes, Trade and Other Receivables Disclosure [Text Block]	5. Amounts Receivable Amounts receivable consisted of accrued interest receivable on marketable securities of $88,000 and $130,000 as of June 30, 2022 and December 31, 2021, respectively.

Note 6 - Deposits

Note 6 - Deposits	6 Months Ended
	Jun. 30, 2022
Notes to Financial Statements
Other Assets Disclosure [Text Block]	6. Deposits Deposits consisted of the following (in thousands): June 30, 2022 December 31, 2021 Advances to vendors, current $ 108 $ 113 We periodically advance funds to vendors engaged to support the performance of our clinical trials and related supporting activities. The funds advanced are held, interest free, for varying periods of time and may be recovered by DiaMedica through full or partial reductions of ongoing invoices, application against final study/project invoices or refunded upon completion of services to be provided. Deposits are classified as current based upon their expected recovery time.

Note 7 - Property and Equipment

Note 7 - Property and Equipment	6 Months Ended
	Jun. 30, 2022
Notes to Financial Statements
Property, Plant and Equipment Disclosure [Text Block]	7. Property and Equipment Property and equipment consisted of the following (in thousands): June 30, 2022 December 31, 2021 Furniture and equipment $ 71 $ 70 Computer equipment 70 67 141 137 Less accumulated depreciation (67 ) (67 ) Property and equipment, net $ 74 $ 70

Note 8 - Accrued Liabilities

Note 8 - Accrued Liabilities	6 Months Ended
	Jun. 30, 2022
Notes to Financial Statements
Accounts Payable and Accrued Liabilities Disclosure [Text Block]	8. Accrued Liabilities Accrued liabilities consisted of the following (in thousands): June 30, 2022 December 31, 2021 Accrued clinical trial costs $ 529 $ 284 Accrued compensation 207 484 Accrued research and other professional fees 151 191 Other liabilities 7 7 Total accrued liabilities $ 894 $ 966

Note 9 - Operating Lease

Note 9 - Operating Lease	6 Months Ended
	Jun. 30, 2022
Notes to Financial Statements
Lessee, Operating Leases [Text Block]	9. Operating Lease We lease certain office space under a non-cancelable operating lease. This lease does not have significant rent escalation holidays, concessions, leasehold improvement incentives or other build-out clauses. Further this lease does not contain contingent rent provisions. This lease terminates on August 31, 2022 and we do not have an option to renew. This lease does include both lease (e.g., fixed rent) and non-lease components (e.g., common-area and other maintenance costs). The non-lease components are deemed to be executory costs and are therefore excluded from the minimum lease payments used to determine the present value of the operating lease obligation and related right-of-use asset. Our operating lease cost and variable lease costs were $32,000 and $ 26,000, Maturities of our operating lease obligation are as follows as of June 30, 2022 (in thousands): 2022 11 Total lease payments $ 11 Less interest portion — Present value of lease obligation $ 11 New office lease In June 2022, we entered into an agreement to lease approximately 6,000 square feet of office space in Minneapolis, MN, near our current office space. The lease commencement date is expected to coincide with the initiation of the lease term on September 1, 2022. The lease term is 65 months, expiring on January 31, 2028. The aggregate base rent due over the initial term under the terms of the lease agreement is approximately $ 608,000, 5-year

Note 10 - Shareholders' Equity

Note 10 - Shareholders' Equity	6 Months Ended
	Jun. 30, 2022
Notes to Financial Statements
Stockholders' Equity Note Disclosure [Text Block]	10. Shareholders Equity Authorized capital stock The Company has authorized share capital of an unlimited number of voting common shares and the shares do not have a stated par value. Common shareholders are entitled to receive dividends as declared by the Company, if any, and are entitled to one vote per share at the Company's annual general meeting and any special meeting. Equity issued during the six months ended June 30, 2022 During the six months ended June 30, 2022, we did not Equity issued during the six months ended June 30, 2021 During the six months ended June 30, 2021, 40,000 common shares were issued upon the exercise of options for gross proceeds of $244,000 with an aggregate intrinsic value of $132,000 and no warrants were exercised. Shares reserved Common shares reserved for future issuance are as follows: June 30, 2022 Common shares issuable upon exercise of employee and non-employee stock options 2,623,998 Common shares issuable upon settlement of deferred stock units 134,402 Common shares issuable upon exercise of common share purchase warrants 265,000 Shares available for grant under the 2019 Omnibus Incentive Plan 2,026,010 Shares available for grant under the 2021 Employment Inducement Incentive Plan 675,000 Total 5,724,410

Note 11 - Net Loss Per Share

Note 11 - Net Loss Per Share	6 Months Ended
	Jun. 30, 2022
Notes to Financial Statements
Earnings Per Share [Text Block]	11. Net Loss Per Share We compute net loss per share by dividing our net loss (the numerator) by the weighted-average number of common shares outstanding (the denominator) during the period. Shares issued during the period and shares reacquired during the period, if any, are weighted for the portion of the period that they were outstanding. The computation of diluted earnings per share, or EPS, is similar to the computation of basic EPS except that the denominator is increased to include the number of additional common shares that would have been outstanding if the dilutive potential common shares had been issued. Our diluted EPS is the same as basic EPS due to common equivalent shares being excluded from the calculation, as their effect is anti-dilutive. The following table summarizes our calculation of net loss per common share for the periods (in thousands, except share and per share data): Three Months Ended June 30, Six Months Ended June 30, 2022 2021 2022 2021 Net loss $ (3,358 ) $ (3,274 ) $ (6,866 ) $ (6,896 ) Weighted average shares outstanding—basic and diluted 26,443,067 18,786,157 26,443,067 18,776,461 Basic and diluted net loss per share $ (0.13 ) $ (0.17 ) $ (0.26 ) $ (0.37 ) The following outstanding potential common shares were not included in the diluted net loss per share calculations as their effects were not dilutive: Three Months Ended June 30, Six Months Ended June 30, 2022 2021 2022 2021 Employee and non-employee stock options 2,623,998 1,421,092 2,623,998 1,421,092 Common shares issuable under common share purchase warrants 265,000 265,000 265,000 265,000 Common shares issuable under deferred stock units 134,402 72,142 134,402 72,142

Note 12 - Share-based Compensat

Note 12 - Share-based Compensation	6 Months Ended
	Jun. 30, 2022
Notes to Financial Statements
Share-Based Payment Arrangement [Text Block]	12. Share-Based Compensation Amended and Restated 2019 Omnibus Incentive Plan At the 2022 Annual General Meeting of Shareholders on May 18, 2022, our shareholders, upon recommendation of our Board of Directors (Board), approved the DiaMedica Therapeutics Inc. Amended and Restated 2019 Omnibus Incentive Plan (the 2019 Plan). The Board approved the 2019 Plan, subject to approval by our shareholders, on March 10, 2022. The 2019 Plan permits the Board, or a committee or subcommittee thereof, to grant to the Company’s eligible employees, non-employee directors and certain consultants non-statutory and incentive stock options, stock appreciation rights, restricted stock awards, restricted stock units, deferred stock units (DSUs), performance awards, non-employee director awards and other stock-based awards. We grant options to purchase common shares under the 2019 Plan at no less than the fair market value of the underlying common shares as of the date of grant. Options granted to employees and non-employee directors have a maximum term of ten one four five one 2021 Employment Inducement Incentive Plan On December 3, 2021, the Board adopted the DiaMedica Therapeutics Inc. 2021 Employment Inducement Incentive Plan (Inducement Plan) to facilitate the granting of equity awards as an inducement material to new employees joining the Company. The Inducement Plan is administered by the Compensation Committee of the Board of Directors. The Board reserved 1,000,000 common shares of the Company for issuance under the Inducement Plan. The only persons eligible to receive awards under the Inducement Plan are individuals who are new employees and satisfy the standards for inducement grants under Nasdaq Listing Rule 5635(c)(4) or 5635(c)(3), as applicable. As of June 30, 2022, options to purchase an aggregate of 325,000 common shares were outstanding under the Inducement Plan. Prior Stock Option Plan The DiaMedica Therapeutics Inc. Stock Option Plan, Amended and Restated November 6, 2018 (Prior Plan), was terminated by the Board of Directors in conjunction with the shareholder approval of the 2019 Plan. Awards outstanding under the Prior Plan remain outstanding in accordance with and pursuant to the terms thereof. Options granted under the Prior Plan have terms similar to those used under the 2019 Plan. As of June 30, 2022, options to purchase an aggregate of 465,410 common shares were outstanding under the Prior Plan. Prior Deferred Stock Unit Plan The DiaMedica Therapeutics Inc. Amended and Restated Deferred Stock Unit Plan (Prior DSU Plan) was terminated by the Board of Directors in conjunction with the shareholder approval of the 2019 Plan. Awards outstanding under the Prior DSU Plan remain outstanding in accordance with and pursuant to the terms thereof. As of June 30, 2022, there were 17,333 common shares reserved for issuance upon settlement of DSUs outstanding under the Prior DSU Plan. Share-based compensation expense for each of the periods presented is as follows (in thousands): Three Months Ended June 30 Six Months Ended June 30 2022 2021 2022 2021 Research and development $ 108 $ 140 $ 199 $ 271 General and administrative 257 306 474 686 Total share-based compensation $ 365 $ 446 $ 673 $ 957 We recognize share-based compensation based on the fair value of each award as estimated using the Black-Scholes option valuation model. Ultimately, the actual expense recognized over the vesting period will only be for those shares that actually vest. A summary of option activity is as follows (in thousands except share and per share amounts): Shares Underlying Options Outstanding Weighted Average Exercise Price Per Share Aggregate Intrinsic Value Balances at December 31, 2021 1,896,600 $ 5.22 $ 169 Granted 837,398 2.81 Exercised — — Expired/cancelled (57,813 ) 8.46 Forfeited (52,187 ) 3.90 Balances at June 30, 2022 2,623,998 $ 4.37 $ — Information about stock options outstanding, vested and expected to vest as of June 30, 2022, is as follows: Outstanding, Vested and Expected to Vest Options Vested and Exercisable Per Share Exercise Price Shares Weighted Average Remaining Contractual Life (Years) Weighted Average Exercise Price Options Exercisable Weighted Average Remaining Contractual Life (Years) $2.00 - $2.99 800,398 8.6 $ 2.53 133,000 4.0 $3.00 - $3.99 328,008 8.6 3.82 85,472 6.9 $4.00 - $4.99 943,567 6.8 4.55 871,399 6.7 $5.00 - $9.99 512,025 8.0 7.96 237,338 6.7 $10.00 - $27.06 40,000 4.0 13.42 31,250 2.7 2,623,998 7.8 $ 4.37 1,358,459 6.3

Significant Accounting Policies

Significant Accounting Policies (Policies)	6 Months Ended
	Jun. 30, 2022
Accounting Policies [Abstract]
Basis of Accounting, Policy [Policy Text Block]	Interim financial statements
Cash and Cash Equivalents, Policy [Policy Text Block]	Cash and cash equivalents
Concentration Risk, Credit Risk, Policy [Policy Text Block]	Concentration of credit risk
Marketable Securities, Policy [Policy Text Block]	Marketable securities
Fair Value Measurement, Policy [Policy Text Block]	Fair value measurements Level 1 Inputs Level 2 Inputs Level 3 Inputs Marketable Securities
Patent Costs [Policy Text Block]	Patent costs

Note 4 - Marketable Securities

Note 4 - Marketable Securities (Tables)	6 Months Ended
	Jun. 30, 2022
Notes Tables
Fair Value, Marketable Securities Measured on a Recurring Basis [Table Text Block]	Fair Value Measurements Using Inputs Considered as of: June 30, 2022 December 31, 2021 Total Level 1 Level 2 Level 3 Total Level 1 Level 2 Level 3 Government securities $ 24,286 $ — $ 24,286 $ — $ 29,421 $ — $ 29,421 $ — Commercial paper and corporate bonds 11,095 — 11,095 — 10,984 — 10,984 — Total $ 35,381 $ — $ 35,381 $ — $ 40,405 $ — $ 40,405 $ —

Note 6 - Deposits (Tables)

Note 6 - Deposits (Tables)	6 Months Ended
	Jun. 30, 2022
Notes Tables
Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Table Text Block]	June 30, 2022 December 31, 2021 Advances to vendors, current $ 108 $ 113

Note 7 - Property and Equipme_2

Note 7 - Property and Equipment (Tables)	6 Months Ended
	Jun. 30, 2022
Notes Tables
Property, Plant and Equipment [Table Text Block]	June 30, 2022 December 31, 2021 Furniture and equipment $ 71 $ 70 Computer equipment 70 67 141 137 Less accumulated depreciation (67 ) (67 ) Property and equipment, net $ 74 $ 70

Note 8 - Accrued Liabilities (T

Note 8 - Accrued Liabilities (Tables)	6 Months Ended
	Jun. 30, 2022
Notes Tables
Schedule of Accrued Liabilities [Table Text Block]	June 30, 2022 December 31, 2021 Accrued clinical trial costs $ 529 $ 284 Accrued compensation 207 484 Accrued research and other professional fees 151 191 Other liabilities 7 7 Total accrued liabilities $ 894 $ 966

Note 9 - Operating Lease (Table

Note 9 - Operating Lease (Tables)	6 Months Ended
	Jun. 30, 2022
Notes Tables
Lessee, Operating Lease, Liability, Maturity [Table Text Block]	2022 11 Total lease payments $ 11 Less interest portion — Present value of lease obligation $ 11

Note 10 - Shareholders' Equity

Note 10 - Shareholders' Equity (Tables)	6 Months Ended
	Jun. 30, 2022
Notes Tables
Common Stock Reserved for Future Issuance [Table Text Block]	June 30, 2022 Common shares issuable upon exercise of employee and non-employee stock options 2,623,998 Common shares issuable upon settlement of deferred stock units 134,402 Common shares issuable upon exercise of common share purchase warrants 265,000 Shares available for grant under the 2019 Omnibus Incentive Plan 2,026,010 Shares available for grant under the 2021 Employment Inducement Incentive Plan 675,000 Total 5,724,410

Note 11 - Net Loss Per Share (T

Note 11 - Net Loss Per Share (Tables)	6 Months Ended
	Jun. 30, 2022
Notes Tables
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]	Three Months Ended June 30, Six Months Ended June 30, 2022 2021 2022 2021 Net loss $ (3,358 ) $ (3,274 ) $ (6,866 ) $ (6,896 ) Weighted average shares outstanding—basic and diluted 26,443,067 18,786,157 26,443,067 18,776,461 Basic and diluted net loss per share $ (0.13 ) $ (0.17 ) $ (0.26 ) $ (0.37 )
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]	Three Months Ended June 30, Six Months Ended June 30, 2022 2021 2022 2021 Employee and non-employee stock options 2,623,998 1,421,092 2,623,998 1,421,092 Common shares issuable under common share purchase warrants 265,000 265,000 265,000 265,000 Common shares issuable under deferred stock units 134,402 72,142 134,402 72,142

Note 12 - Share-based Compens_2

Note 12 - Share-based Compensation (Tables)	6 Months Ended
	Jun. 30, 2022
Notes Tables
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]	Three Months Ended June 30 Six Months Ended June 30 2022 2021 2022 2021 Research and development $ 108 $ 140 $ 199 $ 271 General and administrative 257 306 474 686 Total share-based compensation $ 365 $ 446 $ 673 $ 957
Share-Based Payment Arrangement, Option, Activity [Table Text Block]	Shares Underlying Options Outstanding Weighted Average Exercise Price Per Share Aggregate Intrinsic Value Balances at December 31, 2021 1,896,600 $ 5.22 $ 169 Granted 837,398 2.81 Exercised — — Expired/cancelled (57,813 ) 8.46 Forfeited (52,187 ) 3.90 Balances at June 30, 2022 2,623,998 $ 4.37 $ —
Share-Based Payment Arrangement, Option, Exercise Price Range [Table Text Block]	Outstanding, Vested and Expected to Vest Options Vested and Exercisable Per Share Exercise Price Shares Weighted Average Remaining Contractual Life (Years) Weighted Average Exercise Price Options Exercisable Weighted Average Remaining Contractual Life (Years) $2.00 - $2.99 800,398 8.6 $ 2.53 133,000 4.0 $3.00 - $3.99 328,008 8.6 3.82 85,472 6.9 $4.00 - $4.99 943,567 6.8 4.55 871,399 6.7 $5.00 - $9.99 512,025 8.0 7.96 237,338 6.7 $10.00 - $27.06 40,000 4.0 13.42 31,250 2.7 2,623,998 7.8 $ 4.37 1,358,459 6.3

Note 2 - Risks and Uncertaint_2

Note 2 - Risks and Uncertainties (Details Textual) - USD ($) $ in Thousands	3 Months Ended				6 Months Ended
	Jun. 30, 2022	Mar. 31, 2022	Jun. 30, 2021	Mar. 31, 2021	Jun. 30, 2022	Jun. 30, 2021	Dec. 31, 2021
Retained Earnings (Accumulated Deficit), Total	$ (89,367)				$ (89,367)		$ (82,501)
Net Income (Loss) Attributable to Parent, Total	(3,358)	$ (3,508)	$ (3,274)	$ (3,622)	(6,866)	$ (6,896)
Net Cash Provided by (Used in) Operating Activities, Total					(6,384)	$ (6,402)
Cash, Cash Equivalents, and Short-Term Investments, Total	38,400				38,400
Working Capital	$ 37,600				$ 37,600

Note 3 - Summary of Significa_2

Note 3 - Summary of Significant Accounting Policies (Details Textual) - USD ($)	6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021
General and Administrative Expense [Member]
Patent Expense	$ 90,000	$ 68,000

Note 4 - Marketable Securitie_2

Note 4 - Marketable Securities (Details Textual) - USD ($)	Jun. 30, 2022	Dec. 31, 2021
Accrued Interest Receivable On Available For Sale Securities [Member]
Interest Receivable	$ 88,000	$ 130,000,000,000

Note 4 - Marketable Securitie_3

Note 4 - Marketable Securities - Fair Value of Marketable Securities (Details) - Fair Value, Recurring [Member] - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Total marketable securities	$ 35,381	$ 40,405
Fair Value, Inputs, Level 1 [Member]
Total marketable securities	0	0
Fair Value, Inputs, Level 2 [Member]
Total marketable securities	35,381	40,405
Fair Value, Inputs, Level 3 [Member]
Total marketable securities	0	0
US Government Agencies Debt Securities [Member]
Total marketable securities	24,286	29,421
US Government Agencies Debt Securities [Member] | Fair Value, Inputs, Level 1 [Member]
Total marketable securities	0	0
US Government Agencies Debt Securities [Member] | Fair Value, Inputs, Level 2 [Member]
Total marketable securities	24,286	29,421
US Government Agencies Debt Securities [Member] | Fair Value, Inputs, Level 3 [Member]
Total marketable securities	0	0
Commercial Paper and Corporate Bonds [Member]
Total marketable securities	11,095	10,984
Commercial Paper and Corporate Bonds [Member] | Fair Value, Inputs, Level 1 [Member]
Total marketable securities	0	0
Commercial Paper and Corporate Bonds [Member] | Fair Value, Inputs, Level 2 [Member]
Total marketable securities	11,095	10,984
Commercial Paper and Corporate Bonds [Member] | Fair Value, Inputs, Level 3 [Member]
Total marketable securities	$ 0	$ 0

Note 5 - Amounts Receivable (De

Note 5 - Amounts Receivable (Details Textual) - USD ($)	Jun. 30, 2022	Dec. 31, 2021
Interest Payable, Current	$ 88,000	$ 130,000

Note 6 - Deposits - Deposits (D

Note 6 - Deposits - Deposits (Details) - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Advances to vendors, current	$ 108	$ 113

Note 7 - Property and Equipme_3

Note 7 - Property and Equipment - Property and Equipment (Details) - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Property, plant and equipment, gross	$ 141	$ 137
Less accumulated depreciation	(67)	(67)
Property and equipment, net	74	70
Furniture and Fixtures [Member]
Property, plant and equipment, gross	71	70
Computer Equipment [Member]
Property, plant and equipment, gross	$ 70	$ 67

Note 8 - Accrued Liabilities -

Note 8 - Accrued Liabilities - Accrued Liabilities (Details) - USD ($) $ in Thousands	Jun. 30, 2022	Dec. 31, 2021
Accrued clinical trial costs	$ 529	$ 284
Accrued compensation	207	484
Accrued research and other professional fees	151	191
Other liabilities	7	7
Total accrued liabilities	$ 894	$ 966

Note 9 - Operating Lease (Detai

Note 9 - Operating Lease (Details Textual)	1 Months Ended	6 Months Ended
	Jun. 30, 2022 USD ($) ft²	Jun. 30, 2022 USD ($) ft²
Operating Lease, Cost		$ 32,000
Variable Lease, Cost		$ 26,000
Minneapolis, MN [Member]
Area of Real Estate Property (Square Foot) | ft²	6,000	6,000
Lessee, Operating Lease, Term of Contract (Month)	65 months	65 months
Operating Lease, Expense	$ 608,000
Lessee, Operating Lease, Renewal Term (Year)	5 years	5 years

Note 9 - Operating Lease - Matu

Note 9 - Operating Lease - Maturity of Operating Lease Liability (Details) $ in Thousands	Jun. 30, 2022 USD ($)
2022	$ 11
Total lease payments	11
Less interest portion	0
Present value of lease obligation	$ 11

Note 10 - Shareholders' Equit_2

Note 10 - Shareholders' Equity (Details Textual) - USD ($)	3 Months Ended	6 Months Ended
	Mar. 31, 2021	Jun. 30, 2022	Jun. 30, 2021
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period (in shares)		0
Proceeds from Stock Options Exercised		$ 0	$ 244,000
Stock Issued During Period, Shares, Exercise of Common Stock Warrants (in shares)		0
Common Stock [Member]
Stock Issued During Period, Shares, New Issues (in shares)		0
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period (in shares)	40,000		40,000
Proceeds from Stock Options Exercised			$ 244,000

Note 10 - Shareholders' Equit_3

Note 10 - Shareholders' Equity - Shares Reserved (Details)	Jun. 30, 2022 shares
Common stock reserved for future issuance (in shares)	5,724,410
Stock Options Outstanding [Member]
Common stock reserved for future issuance (in shares)	2,623,998
Deferred Share Units [Member]
Common stock reserved for future issuance (in shares)	134,402
Common Share Purchase Warrants [Member]
Common stock reserved for future issuance (in shares)	265,000
The 2019 Omnibus Incentive Plan [Member]
Common stock reserved for future issuance (in shares)	2,026,010
The 2021 Employment Inducement Incentive Plan [Member]
Common stock reserved for future issuance (in shares)	675,000

Note 11 - Net Loss Per Share -

Note 11 - Net Loss Per Share - Summary of Significant Accounting Policies - Net Loss Per Common Share (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended				6 Months Ended
	Jun. 30, 2022	Mar. 31, 2022	Jun. 30, 2021	Mar. 31, 2021	Jun. 30, 2022	Jun. 30, 2021
Net loss	$ (3,358)	$ (3,508)	$ (3,274)	$ (3,622)	$ (6,866)	$ (6,896)
Weighted average shares outstanding—basic and diluted (in shares)	26,443,067		18,786,157		26,443,067	18,776,461
Basic and diluted net loss per share (in dollars per share)	$ (0.13)		$ (0.17)		$ (0.26)	$ (0.37)

Note 11 - Net Loss Per Share _2

Note 11 - Net Loss Per Share - Schedule of Antidilutive Shares Excluded from Computation of Net Loss Per Share (Details) - shares	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Employee and Non-employee Stock Options [Member]
Antidilutive Securities (in shares)	2,623,998	1,421,092	2,623,998	1,421,092
Warrant [Member]
Antidilutive Securities (in shares)	265,000	265,000	265,000	265,000
Common Stock, Deferred Stock Units Settlement [Member]
Antidilutive Securities (in shares)	134,402	72,142	134,402	72,142

Note 12 - Share-based Compens_3

Note 12 - Share-based Compensation (Details Textual) - shares		6 Months Ended
	May 18, 2022	Jun. 30, 2022	Dec. 31, 2021
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross (in shares)		837,398
Common Stock, Capital Shares Reserved for Future Issuance (in shares)		5,724,410
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number, Ending Balance (in shares)		2,623,998	1,896,600
The 2019 Omnibus Incentive Plan [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Authorized (in shares)	4,000,000
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross (in shares)		1,833,588
Common Stock, Capital Shares Reserved for Future Issuance (in shares)		117,069
The 2019 Omnibus Incentive Plan [Member] | Employee and Non-employee Stock Options [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award, Expiration Period (Year)	10 years
The 2019 Omnibus Incentive Plan [Member] | Employee and Non-employee Stock Options [Member] | Minimum [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period (Year)	1 year
The 2019 Omnibus Incentive Plan [Member] | Phantom Share Units (PSUs) [Member] | Maximum [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period (Year)	4 years
The 2019 Omnibus Incentive Plan [Member] | Nonemployee Stock Options [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award, Expiration Period (Year)	5 years
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period (Year)	1 year
The 2021 Employment Inducement Incentive Plan [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Authorized (in shares)		1,000,000
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross (in shares)		325,000
Stock Option Prior Plan [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number, Ending Balance (in shares)		465,410
The 2012 DSU Plan [Member]
Common Stock, Capital Shares Reserved for Future Issuance (in shares)		17,333

Note 12 - Share-based Compens_4

Note 12 - Share-based Compensation - Share-based Compensation Expense (Details) - USD ($) $ in Thousands	3 Months Ended		6 Months Ended
	Jun. 30, 2022	Jun. 30, 2021	Jun. 30, 2022	Jun. 30, 2021
Total share-based compensation	$ 365	$ 446	$ 673	$ 957
Research and Development Expense [Member]
Total share-based compensation	108	140	199	271
General and Administrative Expense [Member]
Total share-based compensation	$ 257	$ 306	$ 474	$ 686

Note 12 - Share-based Compens_5

Note 12 - Share-based Compensation - Stock Option Activity (Details) - USD ($) $ / shares in Units, $ in Thousands	6 Months Ended
	Jun. 30, 2022	Dec. 31, 2021
Balance (in shares)	1,896,600
Balance, weighted average exercise price (in dollars per share)	$ 5.22
Balance, aggregate intrinsic value	$ 0	$ 169
Granted (in shares)	837,398
Granted, weighted average exercise price (in dollars per share)	$ 2.81
Exercised (in shares)	0
Exercised, weighted average exercise price (in dollars per share)	$ 0
Expired/cancelled (in shares)	(57,813)
Expired / cancelled, weighted average exercise price (in dollars per share)	$ 8.46
Forfeited (in shares)	(52,187)
Forfeited, weighted average exercise price (in dollars per share)	$ 3.90
Balance (in shares)	2,623,998
Balance, weighted average exercise price (in dollars per share)	$ 4.37

Note 12 - Share-based Compens_6

Note 12 - Share-based Compensation - Stock Options Outstanding (Details)	6 Months Ended
	Jun. 30, 2022 $ / shares shares
Outstanding, shares (in shares) | shares	2,623,998
Outstanding, weighted average remaining contractual life (Year)	7 years 9 months 18 days
Outstanding, weighted average exercise price (in dollars per share)	$ 4.37
Exercisable, shares (in shares) | shares	1,358,459
Exercisable, weighted average remaining contractual life (Year)	6 years 3 months 18 days
Exercise Price Range 1 [Member]
Per share exercise price, lower range (in dollars per share)	$ 2
Share-Based Payment Arrangement, Option, Exercise Price Range, Upper Range Limit (in dollars per share)	$ 2.99
Outstanding, shares (in shares) | shares	800,398
Outstanding, weighted average remaining contractual life (Year)	8 years 7 months 6 days
Outstanding, weighted average exercise price (in dollars per share)	$ 2.53
Exercisable, shares (in shares) | shares	133,000
Exercisable, weighted average remaining contractual life (Year)	4 years
Exercise Price Range 2 [Member]
Per share exercise price, lower range (in dollars per share)	$ 3
Share-Based Payment Arrangement, Option, Exercise Price Range, Upper Range Limit (in dollars per share)	$ 3.99
Outstanding, shares (in shares) | shares	328,008
Outstanding, weighted average remaining contractual life (Year)	8 years 7 months 6 days
Outstanding, weighted average exercise price (in dollars per share)	$ 3.82
Exercisable, shares (in shares) | shares	85,472
Exercisable, weighted average remaining contractual life (Year)	6 years 10 months 24 days
Exercise Price Range 3 [Member]
Per share exercise price, lower range (in dollars per share)	$ 4
Share-Based Payment Arrangement, Option, Exercise Price Range, Upper Range Limit (in dollars per share)	$ 4.99
Outstanding, shares (in shares) | shares	943,567
Outstanding, weighted average remaining contractual life (Year)	6 years 9 months 18 days
Outstanding, weighted average exercise price (in dollars per share)	$ 4.55
Exercisable, shares (in shares) | shares	871,399
Exercisable, weighted average remaining contractual life (Year)	6 years 8 months 12 days
Exercise Price Range 4 [Member]
Per share exercise price, lower range (in dollars per share)	$ 5
Share-Based Payment Arrangement, Option, Exercise Price Range, Upper Range Limit (in dollars per share)	$ 9.99
Outstanding, shares (in shares) | shares	512,025
Outstanding, weighted average remaining contractual life (Year)	8 years
Outstanding, weighted average exercise price (in dollars per share)	$ 7.96
Exercisable, shares (in shares) | shares	237,338
Exercisable, weighted average remaining contractual life (Year)	6 years 8 months 12 days
Exercise Price Range 5 [Member]
Per share exercise price, lower range (in dollars per share)	$ 10
Share-Based Payment Arrangement, Option, Exercise Price Range, Upper Range Limit (in dollars per share)	$ 27.06
Outstanding, shares (in shares) | shares	40,000
Outstanding, weighted average remaining contractual life (Year)	4 years
Outstanding, weighted average exercise price (in dollars per share)	$ 13.42
Exercisable, shares (in shares) | shares	31,250
Exercisable, weighted average remaining contractual life (Year)	2 years 8 months 12 days