1 | Names of Reporting Persons
Frazier Life Sciences Public Fund, L.P. |
2 | Check the appropriate box if a member of a Group (see
instructions)

(a) 
(b) |
3 | Sec Use Only |
4 | Citizenship or Place of Organization
DELAWARE |
Number of Shares Beneficially Owned by Each
Reporting Person With: | 5 | Sole Voting Power
0.00 | 6 | Shared Voting Power
878,080.00 | 7 | Sole Dispositive Power
0.00 | 8 | Shared Dispositive Power
878,080.00 |
|
9 | Aggregate Amount Beneficially Owned by Each Reporting
Person
878,080.00 |
10 | Check box if the aggregate amount in row (9) excludes
certain shares (See Instructions)
 |
11 | Percent of class represented by amount in row (9)
1.5 % |
12 | Type of Reporting Person (See Instructions)
PN |
Comment for Type of Reporting Person:
The shares listed in rows 6, 8 and 9 consist of 878,080 shares of Common Stock held directly by Frazier Life Sciences Public Fund, L.P. FHMLSP, L.P. is the general partner of Frazier Life Sciences Public Fund, L.P. and FHMLSP, L.L.C. is the general partner of FHMLSP, L.P. Patrick J. Heron, James N. Topper, Albert Cha and James Brush are the members of FHMLSP, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences Public Fund, L.P.
The percentage listed in row 11 is calculated based on 59,739,275 shares of Common Stock outstanding on November 8, 2024, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 12, 2024.
1 | Names of Reporting Persons
FHMLSP, L.P. |
2 | Check the appropriate box if a member of a Group (see
instructions)

(a) 
(b) |
3 | Sec Use Only |
4 | Citizenship or Place of Organization
DELAWARE |
Number of Shares Beneficially Owned by Each
Reporting Person With: | 5 | Sole Voting Power
0.00 | 6 | Shared Voting Power
878,080.00 | 7 | Sole Dispositive Power
0.00 | 8 | Shared Dispositive Power
878,080.00 |
|
9 | Aggregate Amount Beneficially Owned by Each Reporting
Person
878,080.00 |
10 | Check box if the aggregate amount in row (9) excludes
certain shares (See Instructions)
 |
11 | Percent of class represented by amount in row (9)
1.5 % |
12 | Type of Reporting Person (See Instructions)
PN |
Comment for Type of Reporting Person:
The shares listed in rows 6, 8 and 9 consist of 878,080 shares of Common Stock held directly by Frazier Life Sciences Public Fund, L.P. FHMLSP, L.P. is the general partner of Frazier Life Sciences Public Fund, L.P. and FHMLSP, L.L.C. is the general partner of FHMLSP, L.P. Patrick J. Heron, James N. Topper, Albert Cha and James Brush are the members of FHMLSP, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences Public Fund, L.P.
The percentage listed in row 11 is calculated based on 59,739,275 shares of Common Stock outstanding on November 8, 2024, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 12, 2024.
1 | Names of Reporting Persons
FHMLSP, L.L.C. |
2 | Check the appropriate box if a member of a Group (see
instructions)

(a) 
(b) |
3 | Sec Use Only |
4 | Citizenship or Place of Organization
DELAWARE |
Number of Shares Beneficially Owned by Each
Reporting Person With: | 5 | Sole Voting Power
0.00 | 6 | Shared Voting Power
878,080.00 | 7 | Sole Dispositive Power
0.00 | 8 | Shared Dispositive Power
878,080.00 |
|
9 | Aggregate Amount Beneficially Owned by Each Reporting
Person
878,080.00 |
10 | Check box if the aggregate amount in row (9) excludes
certain shares (See Instructions)
 |
11 | Percent of class represented by amount in row (9)
1.5 % |
12 | Type of Reporting Person (See Instructions)
OO |
Comment for Type of Reporting Person:
The shares listed in rows 6, 8 and 9 consist of 878,080 shares of Common Stock held directly by Frazier Life Sciences Public Fund, L.P. FHMLSP, L.P. is the general partner of Frazier Life Sciences Public Fund, L.P. and FHMLSP, L.L.C. is the general partner of FHMLSP, L.P. Patrick J. Heron, James N. Topper, Albert Cha and James Brush are the members of FHMLSP, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences Public Fund, L.P.
The percentage listed in row 11 is calculated based on 59,739,275 shares of Common Stock outstanding on November 8, 2024, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 12, 2024.
1 | Names of Reporting Persons
Frazier Life Sciences Public Overage Fund, L.P. |
2 | Check the appropriate box if a member of a Group (see
instructions)

(a) 
(b) |
3 | Sec Use Only |
4 | Citizenship or Place of Organization
DELAWARE |
Number of Shares Beneficially Owned by Each
Reporting Person With: | 5 | Sole Voting Power
0.00 | 6 | Shared Voting Power
258,998.00 | 7 | Sole Dispositive Power
0.00 | 8 | Shared Dispositive Power
258,998.00 |
|
9 | Aggregate Amount Beneficially Owned by Each Reporting
Person
258,998.00 |
10 | Check box if the aggregate amount in row (9) excludes
certain shares (See Instructions)
 |
11 | Percent of class represented by amount in row (9)
0.4 % |
12 | Type of Reporting Person (See Instructions)
PN |
Comment for Type of Reporting Person:
The shares listed in rows 6, 8 and 9 consist of 258,998 shares of Common Stock held directly by Frazier Life Sciences Public Overage Fund, L.P. FHMLSP Overage, L.P. is the general partner of Frazier Life Sciences Public Overage Fund, L.P. and FHMLSP Overage, L.L.C. is the general partner of FHMLSP Overage, L.P. Patrick J. Heron, James N. Topper, Albert Cha and James Brush are the members of FHMLSP Overage, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences Public Overage Fund, L.P.
The percentage listed in row 11 is calculated based on 59,739,275 shares of Common Stock outstanding on November 8, 2024, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 12, 2024.
1 | Names of Reporting Persons
FHMLSP Overage, L.P. |
2 | Check the appropriate box if a member of a Group (see
instructions)

(a) 
(b) |
3 | Sec Use Only |
4 | Citizenship or Place of Organization
DELAWARE |
Number of Shares Beneficially Owned by Each
Reporting Person With: | 5 | Sole Voting Power
0.00 | 6 | Shared Voting Power
258,998.00 | 7 | Sole Dispositive Power
0.00 | 8 | Shared Dispositive Power
258,998.00 |
|
9 | Aggregate Amount Beneficially Owned by Each Reporting
Person
258,998.00 |
10 | Check box if the aggregate amount in row (9) excludes
certain shares (See Instructions)
 |
11 | Percent of class represented by amount in row (9)
0.4 % |
12 | Type of Reporting Person (See Instructions)
PN |
Comment for Type of Reporting Person:
The shares listed in rows 6, 8 and 9 consist of 258,998 shares of Common Stock held directly by Frazier Life Sciences Public Overage Fund, L.P. FHMLSP Overage, L.P. is the general partner of Frazier Life Sciences Public Overage Fund, L.P. and FHMLSP Overage, L.L.C. is the general partner of FHMLSP Overage, L.P. Patrick J. Heron, James N. Topper, Albert Cha and James Brush are the members of FHMLSP Overage, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences Public Overage Fund, L.P.
The percentage listed in row 11 is calculated based on 59,739,275 shares of Common Stock outstanding on November 8, 2024, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 12, 2024.
1 | Names of Reporting Persons
FHMLSP Overage, L.L.C. |
2 | Check the appropriate box if a member of a Group (see
instructions)

(a) 
(b) |
3 | Sec Use Only |
4 | Citizenship or Place of Organization
DELAWARE |
Number of Shares Beneficially Owned by Each
Reporting Person With: | 5 | Sole Voting Power
0.00 | 6 | Shared Voting Power
258,998.00 | 7 | Sole Dispositive Power
0.00 | 8 | Shared Dispositive Power
258,998.00 |
|
9 | Aggregate Amount Beneficially Owned by Each Reporting
Person
258,998.00 |
10 | Check box if the aggregate amount in row (9) excludes
certain shares (See Instructions)
 |
11 | Percent of class represented by amount in row (9)
0.4 % |
12 | Type of Reporting Person (See Instructions)
OO |
Comment for Type of Reporting Person:
The shares listed in rows 6, 8 and 9 consist of 258,998 shares of Common Stock held directly by Frazier Life Sciences Public Overage Fund, L.P. FHMLSP Overage, L.P. is the general partner of Frazier Life Sciences Public Overage Fund, L.P. and FHMLSP Overage, L.L.C. is the general partner of FHMLSP Overage, L.P. Patrick J. Heron, James N. Topper, Albert Cha and James Brush are the members of FHMLSP Overage, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences Public Overage Fund, L.P.
The percentage listed in row 11 is calculated based on 59,739,275 shares of Common Stock outstanding on November 8, 2024, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 12, 2024.
1 | Names of Reporting Persons
Frazier Life Sciences X, L.P. |
2 | Check the appropriate box if a member of a Group (see
instructions)

(a) 
(b) |
3 | Sec Use Only |
4 | Citizenship or Place of Organization
DELAWARE |
Number of Shares Beneficially Owned by Each
Reporting Person With: | 5 | Sole Voting Power
0.00 | 6 | Shared Voting Power
13,062.00 | 7 | Sole Dispositive Power
0.00 | 8 | Shared Dispositive Power
13,062.00 |
|
9 | Aggregate Amount Beneficially Owned by Each Reporting
Person
13,062.00 |
10 | Check box if the aggregate amount in row (9) excludes
certain shares (See Instructions)
 |
11 | Percent of class represented by amount in row (9)
0.0 % |
12 | Type of Reporting Person (See Instructions)
PN |
Comment for Type of Reporting Person:
The shares listed in rows 6, 8 and 9 consist of 13,062 shares of Common Stock held directly by Frazier Life Sciences X, L.P. FHMLS X, L.P. is the general partner of Frazier Life Sciences X, L.P. and FHMLS X, L.L.C. is the general partner of FHMLS X, L.P. Patrick J. Heron and James N. Topper are the members of FHMLS X, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences X, L.P.
The percentage listed in row 11 is calculated based on 59,739,275 shares of Common Stock outstanding on November 8, 2024, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 12, 2024.
1 | Names of Reporting Persons
FHMLS X, L.P. |
2 | Check the appropriate box if a member of a Group (see
instructions)

(a) 
(b) |
3 | Sec Use Only |
4 | Citizenship or Place of Organization
DELAWARE |
Number of Shares Beneficially Owned by Each
Reporting Person With: | 5 | Sole Voting Power
0.00 | 6 | Shared Voting Power
13,062.00 | 7 | Sole Dispositive Power
0.00 | 8 | Shared Dispositive Power
13,062.00 |
|
9 | Aggregate Amount Beneficially Owned by Each Reporting
Person
13,062.00 |
10 | Check box if the aggregate amount in row (9) excludes
certain shares (See Instructions)
 |
11 | Percent of class represented by amount in row (9)
0.0 % |
12 | Type of Reporting Person (See Instructions)
PN |
Comment for Type of Reporting Person:
The shares listed in rows 6, 8 and 9 consist of 13,062 shares of Common Stock held directly by Frazier Life Sciences X, L.P. FHMLS X, L.P. is the general partner of Frazier Life Sciences X, L.P. and FHMLS X, L.L.C. is the general partner of FHMLS X, L.P. Patrick J. Heron and James N. Topper are the members of FHMLS X, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences X, L.P.
The percentage listed in row 11 is calculated based on 59,739,275 shares of Common Stock outstanding on November 8, 2024, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 12, 2024.
1 | Names of Reporting Persons
FHMLS X, L.L.C. |
2 | Check the appropriate box if a member of a Group (see
instructions)

(a) 
(b) |
3 | Sec Use Only |
4 | Citizenship or Place of Organization
DELAWARE |
Number of Shares Beneficially Owned by Each
Reporting Person With: | 5 | Sole Voting Power
0.00 | 6 | Shared Voting Power
13,062.00 | 7 | Sole Dispositive Power
0.00 | 8 | Shared Dispositive Power
13,062.00 |
|
9 | Aggregate Amount Beneficially Owned by Each Reporting
Person
13,062.00 |
10 | Check box if the aggregate amount in row (9) excludes
certain shares (See Instructions)
 |
11 | Percent of class represented by amount in row (9)
0.0 % |
12 | Type of Reporting Person (See Instructions)
OO |
Comment for Type of Reporting Person:
The shares listed in rows 6, 8 and 9 consist of 13,062 shares of Common Stock held directly by Frazier Life Sciences X, L.P. FHMLS X, L.P. is the general partner of Frazier Life Sciences X, L.P. and FHMLS X, L.L.C. is the general partner of FHMLS X, L.P. Patrick J. Heron and James N. Topper are the members of FHMLS X, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences X, L.P.
The percentage listed in row 11 is calculated based on 59,739,275 shares of Common Stock outstanding on November 8, 2024, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 12, 2024.
1 | Names of Reporting Persons
Frazier Life Sciences XI, L.P. |
2 | Check the appropriate box if a member of a Group (see
instructions)

(a) 
(b) |
3 | Sec Use Only |
4 | Citizenship or Place of Organization
DELAWARE |
Number of Shares Beneficially Owned by Each
Reporting Person With: | 5 | Sole Voting Power
0.00 | 6 | Shared Voting Power
26,595.00 | 7 | Sole Dispositive Power
0.00 | 8 | Shared Dispositive Power
26,595.00 |
|
9 | Aggregate Amount Beneficially Owned by Each Reporting
Person
26,595.00 |
10 | Check box if the aggregate amount in row (9) excludes
certain shares (See Instructions)
 |
11 | Percent of class represented by amount in row (9)
0.0 % |
12 | Type of Reporting Person (See Instructions)
PN |
Comment for Type of Reporting Person:
The shares listed in rows 6, 8 and 9 consist of 26,595 shares of Common Stock held directly by Frazier Life Sciences XI, L.P. FHMLS XI, L.P. is the general partner of Frazier Life Sciences XI, L.P. and FHMLS XI, L.L.C. is the general partner of FHMLS XI, L.P. Patrick J. Heron, James N. Topper and Daniel Estes are the members of FHMLS XI, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences XI, L.P.
The percentage listed in row 11 is calculated based on 59,739,275 shares of Common Stock outstanding on November 8, 2024, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 12, 2024.
1 | Names of Reporting Persons
FHMLS XI, L.P. |
2 | Check the appropriate box if a member of a Group (see
instructions)

(a) 
(b) |
3 | Sec Use Only |
4 | Citizenship or Place of Organization
DELAWARE |
Number of Shares Beneficially Owned by Each
Reporting Person With: | 5 | Sole Voting Power
0.00 | 6 | Shared Voting Power
26,595.00 | 7 | Sole Dispositive Power
0.00 | 8 | Shared Dispositive Power
26,595.00 |
|
9 | Aggregate Amount Beneficially Owned by Each Reporting
Person
26,595.00 |
10 | Check box if the aggregate amount in row (9) excludes
certain shares (See Instructions)
 |
11 | Percent of class represented by amount in row (9)
0.0 % |
12 | Type of Reporting Person (See Instructions)
PN |
Comment for Type of Reporting Person:
The shares listed in rows 6, 8 and 9 consist of 26,595 shares of Common Stock held directly by Frazier Life Sciences XI, L.P. FHMLS XI, L.P. is the general partner of Frazier Life Sciences XI, L.P. and FHMLS XI, L.L.C. is the general partner of FHMLS XI, L.P. Patrick J. Heron, James N. Topper and Daniel Estes are the members of FHMLS XI, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences XI, L.P.
The percentage listed in row 11 is calculated based on 59,739,275 shares of Common Stock outstanding on November 8, 2024, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 12, 2024.
1 | Names of Reporting Persons
FHMLS XI, L.L.C. |
2 | Check the appropriate box if a member of a Group (see
instructions)

(a) 
(b) |
3 | Sec Use Only |
4 | Citizenship or Place of Organization
DELAWARE |
Number of Shares Beneficially Owned by Each
Reporting Person With: | 5 | Sole Voting Power
0.00 | 6 | Shared Voting Power
26,595.00 | 7 | Sole Dispositive Power
0.00 | 8 | Shared Dispositive Power
26,595.00 |
|
9 | Aggregate Amount Beneficially Owned by Each Reporting
Person
26,595.00 |
10 | Check box if the aggregate amount in row (9) excludes
certain shares (See Instructions)
 |
11 | Percent of class represented by amount in row (9)
0.0 % |
12 | Type of Reporting Person (See Instructions)
OO |
Comment for Type of Reporting Person:
The shares listed in rows 6, 8 and 9 consist of 26,595 shares of Common Stock held directly by Frazier Life Sciences XI, L.P. FHMLS XI, L.P. is the general partner of Frazier Life Sciences XI, L.P. and FHMLS XI, L.L.C. is the general partner of FHMLS XI, L.P. Patrick J. Heron, James N. Topper and Daniel Estes are the members of FHMLS XI, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences XI, L.P.
The percentage listed in row 11 is calculated based on 59,739,275 shares of Common Stock outstanding on November 8, 2024, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 12, 2024.
1 | Names of Reporting Persons
James N. Topper |
2 | Check the appropriate box if a member of a Group (see
instructions)

(a) 
(b) |
3 | Sec Use Only |
4 | Citizenship or Place of Organization
UNITED STATES |
Number of Shares Beneficially Owned by Each
Reporting Person With: | 5 | Sole Voting Power
0.00 | 6 | Shared Voting Power
1,176,735.00 | 7 | Sole Dispositive Power
0.00 | 8 | Shared Dispositive Power
1,176,735.00 |
|
9 | Aggregate Amount Beneficially Owned by Each Reporting
Person
1,176,735.00 |
10 | Check box if the aggregate amount in row (9) excludes
certain shares (See Instructions)
 |
11 | Percent of class represented by amount in row (9)
2.0 % |
12 | Type of Reporting Person (See Instructions)
IN |
Comment for Type of Reporting Person:
The shares listed in rows 6, 8 and 9 consist of (i) 878,080 shares of Common Stock held directly by Frazier Life Sciences Public Fund, L.P., (ii) 258,998 shares of Common Stock held directly by Frazier Life Sciences Public Overage Fund, L.P., (iii) 13,062 shares of Common Stock held directly by Frazier Life Sciences X, L.P., and (iv) 26,595 shares of Common Stock held directly by Frazier Life Sciences XI, L.P. FHMLSP, L.P. is the general partner of Frazier Life Sciences Public Fund, L.P. and FHMLSP, L.L.C. is the general partner of FHMLSP, L.P. Patrick J. Heron, James N. Topper, Albert Cha and James Brush are the members of FHMLSP, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences Public Fund, L.P. FHMLSP Overage, L.P. is the general partner of Frazier Life Sciences Public Overage Fund, L.P. and FHMLSP Overage, L.L.C. is the general partner of FHMLSP Overage, L.P. Patrick J. Heron, James N. Topper, Albert Cha and James Brush are the members of FHMLSP Overage, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences Public Overage Fund, L.P. FHMLS X, L.P. is the general partner of Frazier Life Sciences X, L.P. and FHMLS X, L.L.C. is the general partner of FHMLS X, L.P. Patrick J. Heron and James N. Topper are the members of FHMLS X, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences X, L.P. FHMLS XI, L.P. is the general partner of Frazier Life Sciences XI, L.P. and FHMLS XI, L.L.C. is the general partner of FHMLS XI, L.P. Patrick J. Heron, James N. Topper and Daniel Estes are the members of FHMLS XI, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences XI, L.P.
The percentage listed in row 11 is calculated based on 59,739,275 shares of Common Stock outstanding on November 8, 2024, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 12, 2024.
1 | Names of Reporting Persons
Patrick J. Heron |
2 | Check the appropriate box if a member of a Group (see
instructions)

(a) 
(b) |
3 | Sec Use Only |
4 | Citizenship or Place of Organization
UNITED STATES |
Number of Shares Beneficially Owned by Each
Reporting Person With: | 5 | Sole Voting Power
0.00 | 6 | Shared Voting Power
1,176,735.00 | 7 | Sole Dispositive Power
0.00 | 8 | Shared Dispositive Power
1,176,735.00 |
|
9 | Aggregate Amount Beneficially Owned by Each Reporting
Person
1,176,735.00 |
10 | Check box if the aggregate amount in row (9) excludes
certain shares (See Instructions)
 |
11 | Percent of class represented by amount in row (9)
2.0 % |
12 | Type of Reporting Person (See Instructions)
IN |
Comment for Type of Reporting Person:
The shares listed in rows 6, 8 and 9 consist of (i) 878,080 shares of Common Stock held directly by Frazier Life Sciences Public Fund, L.P., (ii) 258,998 shares of Common Stock held directly by Frazier Life Sciences Public Overage Fund, L.P., (iii) 13,062 shares of Common Stock held directly by Frazier Life Sciences X, L.P., and (iv) 26,595 shares of Common Stock held directly by Frazier Life Sciences XI, L.P. FHMLSP, L.P. is the general partner of Frazier Life Sciences Public Fund, L.P. and FHMLSP, L.L.C. is the general partner of FHMLSP, L.P. Patrick J. Heron, James N. Topper, Albert Cha and James Brush are the members of FHMLSP, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences Public Fund, L.P. FHMLSP Overage, L.P. is the general partner of Frazier Life Sciences Public Overage Fund, L.P. and FHMLSP Overage, L.L.C. is the general partner of FHMLSP Overage, L.P. Patrick J. Heron, James N. Topper, Albert Cha and James Brush are the members of FHMLSP Overage, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences Public Overage Fund, L.P. FHMLS X, L.P. is the general partner of Frazier Life Sciences X, L.P. and FHMLS X, L.L.C. is the general partner of FHMLS X, L.P. Patrick J. Heron and James N. Topper are the members of FHMLS X, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences X, L.P. FHMLS XI, L.P. is the general partner of Frazier Life Sciences XI, L.P. and FHMLS XI, L.L.C. is the general partner of FHMLS XI, L.P. Patrick J. Heron, James N. Topper and Daniel Estes are the members of FHMLS XI, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences XI, L.P.
The percentage listed in row 11 is calculated based on 59,739,275 shares of Common Stock outstanding on November 8, 2024, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 12, 2024.
1 | Names of Reporting Persons
Albert Cha |
2 | Check the appropriate box if a member of a Group (see
instructions)

(a) 
(b) |
3 | Sec Use Only |
4 | Citizenship or Place of Organization
UNITED STATES |
Number of Shares Beneficially Owned by Each
Reporting Person With: | 5 | Sole Voting Power
0.00 | 6 | Shared Voting Power
1,137,078.00 | 7 | Sole Dispositive Power
0.00 | 8 | Shared Dispositive Power
1,137,078.00 |
|
9 | Aggregate Amount Beneficially Owned by Each Reporting
Person
1,137,078.00 |
10 | Check box if the aggregate amount in row (9) excludes
certain shares (See Instructions)
 |
11 | Percent of class represented by amount in row (9)
1.9 % |
12 | Type of Reporting Person (See Instructions)
IN |
Comment for Type of Reporting Person:
The shares listed in rows 6, 8 and 9 consist of (i) 878,080 shares of Common Stock held directly by Frazier Life Sciences Public Fund, L.P., and (ii) 258,998 shares of Common Stock held directly by Frazier Life Sciences Public Overage Fund, L.P. FHMLSP, L.P. is the general partner of Frazier Life Sciences Public Fund, L.P. and FHMLSP, L.L.C. is the general partner of FHMLSP, L.P. Patrick J. Heron, James N. Topper, Albert Cha and James Brush are the members of FHMLSP, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences Public Fund, L.P. FHMLSP Overage, L.P. is the general partner of Frazier Life Sciences Public Overage Fund, L.P. and FHMLSP Overage, L.L.C. is the general partner of FHMLSP Overage, L.P. Patrick J. Heron, James N. Topper, Albert Cha and James Brush are the members of FHMLSP Overage, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences Public Overage Fund, L.P.
The percentage listed in row 11 is calculated based on 59,739,275 shares of Common Stock outstanding on November 8, 2024, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 12, 2024.
1 | Names of Reporting Persons
James Brush |
2 | Check the appropriate box if a member of a Group (see
instructions)

(a) 
(b) |
3 | Sec Use Only |
4 | Citizenship or Place of Organization
UNITED STATES |
Number of Shares Beneficially Owned by Each
Reporting Person With: | 5 | Sole Voting Power
0.00 | 6 | Shared Voting Power
1,137,078.00 | 7 | Sole Dispositive Power
0.00 | 8 | Shared Dispositive Power
1,137,078.00 |
|
9 | Aggregate Amount Beneficially Owned by Each Reporting
Person
1,137,078.00 |
10 | Check box if the aggregate amount in row (9) excludes
certain shares (See Instructions)
 |
11 | Percent of class represented by amount in row (9)
1.9 % |
12 | Type of Reporting Person (See Instructions)
IN |
Comment for Type of Reporting Person:
The shares listed in rows 6, 8 and 9 consist of (i) 878,080 shares of Common Stock held directly by Frazier Life Sciences Public Fund, L.P., and (ii) 258,998 shares of Common Stock held directly by Frazier Life Sciences Public Overage Fund, L.P. FHMLSP, L.P. is the general partner of Frazier Life Sciences Public Fund, L.P. and FHMLSP, L.L.C. is the general partner of FHMLSP, L.P. Patrick J. Heron, James N. Topper, Albert Cha and James Brush are the members of FHMLSP, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences Public Fund, L.P. FHMLSP Overage, L.P. is the general partner of Frazier Life Sciences Public Overage Fund, L.P. and FHMLSP Overage, L.L.C. is the general partner of FHMLSP Overage, L.P. Patrick J. Heron, James N. Topper, Albert Cha and James Brush are the members of FHMLSP Overage, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences Public Overage Fund, L.P.
The percentage listed in row 11 is calculated based on 59,739,275 shares of Common Stock outstanding on November 8, 2024, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 12, 2024.
1 | Names of Reporting Persons
Daniel Estes |
2 | Check the appropriate box if a member of a Group (see
instructions)

(a) 
(b) |
3 | Sec Use Only |
4 | Citizenship or Place of Organization
UNITED STATES |
Number of Shares Beneficially Owned by Each
Reporting Person With: | 5 | Sole Voting Power
0.00 | 6 | Shared Voting Power
26,595.00 | 7 | Sole Dispositive Power
0.00 | 8 | Shared Dispositive Power
26,595.00 |
|
9 | Aggregate Amount Beneficially Owned by Each Reporting
Person
26,595.00 |
10 | Check box if the aggregate amount in row (9) excludes
certain shares (See Instructions)
 |
11 | Percent of class represented by amount in row (9)
0.0 % |
12 | Type of Reporting Person (See Instructions)
IN |
Comment for Type of Reporting Person:
The shares listed in rows 6, 8 and 9 consist of 26,595 shares of Common Stock held directly by Frazier Life Sciences XI, L.P. FHMLS XI, L.P. is the general partner of Frazier Life Sciences XI, L.P. and FHMLS XI, L.L.C. is the general partner of FHMLS XI, L.P. Patrick J. Heron, James N. Topper and Daniel Estes are the members of FHMLS XI, L.L.C. and therefore share voting and investment power over the shares held by Frazier Life Sciences XI, L.P.
The percentage listed in row 11 is calculated based on 59,739,275 shares of Common Stock outstanding on November 8, 2024, as set forth in the Issuer's Quarterly Report on Form 10-Q filed with the SEC on November 12, 2024.