Exhibit 23.1
CONSENT OF INDEPENDENT AUDITOR
We consent to the incorporation by reference in RegistrationStatement Nos. 333-194490,333-203179,333-210172,333-216572,333-223589 and333-234734 onForm S-8 andNos. 333-203180, 333-208651, 333-215457 and 333-223584 onForm S-3 of our report dated August 2, 2019, which includes an emphasis-of-a-matter paragraph regarding Neoleukin Therapeutics, Inc.’s ability to continue as a going concern, relating to the financial statements of Neoleukin Therapeutics, Inc. appearing in this Current Report onForm 8-K/A of Neoleukin Therapeutics, Inc. dated December 17, 2019. We also consent to the reference to our Firm as experts.
/s/ CohnReznick LLP
Roseland, New Jersey
December 16, 2019