EXHIBIT 99.1
Joint Filing Agreement
The undersigned acknowledge and agree that the foregoing statement on Schedule 13G is filed on behalf of each of the undersigned and that all subsequent amendments to this statement on Schedule 13G shall be filed on behalf of each of the undersigned without the necessity of filing additional joint filing statements. The undersigned acknowledge that each shall be responsible for the timely filing of such amendments, and for the completeness and accuracy of the information concerning him, her or it contained herein, but shall not be responsible for the completeness and accuracy of the information concerning the other entities or persons, except to the extent that he, she or it knows or has reason to believe that such information is inaccurate.
Dated: February 10, 2016
| THIRD ROCK VENTURES, L.P. | ||
| By: | THIRD ROCK VENTURES GP, L.P., | |
| General Partner | ||
| By: | TRV GP, LLC, | |
| General Partner | ||
| By: | /s/ Kevin Gillis | |
| Kevin Gillis | ||
| Chief Financial Officer | ||
| THIRD ROCK VENTURES GP, L.P. | ||
| By: | TRV GP, LLC, | |
| General Partner | ||
| By: | /s/ Kevin Gillis | |
| Kevin Gillis | ||
| Chief Financial Officer | ||
| TRV GP, LLC | ||
| By: | /s/ Kevin Gillis | |
| Kevin Gillis | ||
| Chief Financial Officer | ||
| MARK LEVIN | ||
/s/ Kevin Gillis, As attorney-in-fact | ||
| Mark Levin | ||
| KEVIN P. STARR | ||
/s/ Kevin Gillis, As attorney-in-fact | ||
| Kevin P. Starr | ||
| ROBERT I. TEPPER | ||
/s/ Kevin Gillis, As attorney-in-fact | ||
| Robert I. Tepper | ||