Significant Accounting Policies [Text Block] | Note 3. Summary of Significant Accounting Policies Use of Estimates The preparation of financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities, the disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the reporting period. Actual results could differ from those estimates. Significant estimates include those relating to revenue recognition, share-based compensation, right-of-use assets and lease liabilities and assumptions that have been used historically to value warrants and warrant modifications. Cash and Cash Equivalents Cash and cash equivalents are considered to be highly liquid investments with maturities of three Revenue Recognition The AffaMed Agreement, involving clinical development and commercialization of PH94B nine December 31, 2022 2022 2021. August 2020, Under Accounting Standards Codification ( ASC 606, Revenue from Contracts with Customers (ASC 606 606, five five Once a contract is determined to be within the scope of ASC 606, may We assess whether each promised good or service is distinct for the purpose of identifying the performance obligations in the contract. This assessment involves subjective determinations and requires judgments about the individual promised goods or services and whether such are separable from the other aspects of the contractual relationship. Promised goods and services are considered distinct provided that (i) the customer can benefit from the good or service either on its own or together with other resources that are readily available to the customer (that is, the good or service is capable of being distinct) and (ii) our promise to transfer the good or service to the customer is separately identifiable from other promises in the contract (that is, the promise to transfer the good or service is distinct within the context of the contract). In assessing whether a promised good or service is distinct in the evaluation of a collaboration arrangement subject to ASC 606, not The transaction price is then determined and allocated to the identified performance obligations in proportion to their standalone selling prices ( SSP not may If the consideration promised in a contract includes a variable amount, we estimate the amount of consideration to which we will be entitled in exchange for transferring the promised goods or services to a customer. We determine the amount of variable consideration by using the expected value method or the most likely amount method. We include the unconstrained amount of estimated variable consideration in the transaction price. The amount included in the transaction price is constrained to the amount for which it is probable that a significant reversal of cumulative revenue recognized will not If an arrangement includes development and regulatory milestone payments, we evaluate whether the milestones are considered probable of being reached and estimate the amount to be included in the transaction price using the most likely amount method. If it is probable that a significant revenue reversal would not not not In determining the transaction price, we adjust consideration for the effects of the time value of money if the timing of payments provides us with a significant benefit of financing. We do not one We then recognize as revenue the amount of the transaction price that is allocated to the respective performance obligation when (or as) each performance obligation is satisfied at a point in time or over time, and if over time, based on the use of an output or input method. For the single combined performance obligation under the AffaMed Agreement, the measure of progress is stand-ready straight-line over the period in which we expect to perform the services related to the license of PH94B. The difference between revenue recognized to date and the consideration invoiced or received to date is recognized as either a contract asset/unbilled revenue (revenue earned exceeds cash received) or a contract liability/deferred revenue (cash received exceeds revenue earned). As described more completely in Note 11, Sublicensing and Collaborative Agreements 1, 606, three six September 30, 2022, June 30, 2022. December 31, 2022. December 31, 2022, nine December 31, 2022 Balance at Balance at March 31, 2022 Additions Deductions December 31, 2022 Deferred Revenue - current portion $ 1,244,000 $ - $ (531,700 ) $ 712,300 Deferred Revenue - non-current portion 1,557,600 1,114,200 (179,600 ) 2,492,200 Total $ 2,801,600 $ 1,114,200 $ (711,300 ) $ 3,204,500 During the three nine December 31, 2022, three nine December 31, 2021, Contract Acquisition Costs During the quarter ended September 30, 2020, PH94B Pherin June 24, 2020, three six September 30, 2022, June 30, 2022, December 31, 2022, nine December 31, 2022. three nine December 31, 2021, no The following table summarizes our contract acquisition costs for the nine December 31, 2022 Balance at Balance at March 31, 2022 Additions Deductions December 31, 2022 Deferred Contract Acquisition Costs - current portion $ 116,900 $ - $ (49,900 ) $ 67,000 Deferred Contract Acquisition Costs - non-current portion 146,400 87,800 - 234,200 Total $ 263,300 $ 87,800 $ (49,900 ) $ 301,200 Research and Development Expense Research and development expense is composed of both internal and external costs. Internal costs include salaries and employment-related expense, including stock-based compensation expense, of scientific personnel and direct project costs. External research and development expense consists primarily of costs associated with clinical and nonclinical development of PH94B, PH10, 101. We also record accruals for estimated ongoing clinical trial costs. Clinical trial costs represent costs incurred by contract research organizations ( CRO Costs incurred in obtaining product or technology licenses are charged immediately to research and development expense if the product or technology licensed has not no PH94B PH10 March 31, 2019. Stock-Based Compensation We recognize compensation cost for all stock-based awards to employees, independent directors and non-employee consultants based on the grant date fair value of the award. We record stock-based compensation expense over the period during which the employee or other grantee is required to perform services in exchange for the award, which generally represents the scheduled vesting period. We have not The table below summarizes stock-based compensation expense included in the accompanying Condensed Consolidated Statements of Operations and Comprehensive Loss: Three Months Ended December 31, Nine Months Ended December 31, 2022 2021 2022 2021 Research and development expense $ 296,200 $ 281,800 $ 1,091,900 $ 836,200 General and administrative expense 450,100 442,000 1,643,000 1,242,500 Total stock-based compensation expense $ 746,300 $ 723,800 $ 2,734,900 $ 2,078,700 Expense amounts reported above include $9,500 and $34,900 in research and development expense for the three nine December 31, 2022, three nine December 31, 2022, 2019 three nine December 31, 2021, three nine December 31, 2021, 2019 During the nine December 31, 2022, 2019 2019 Board November 2022, first three twelve November 2022 nine December 31, 2022 Assumption: Weighted Average Range Market price per share at grant date $ 0.34 $ 0.12 1.51 Exercise price per share $ 0.34 $ 0.12 1.51 Risk-free interest rate 3.55 % 2.63% to 3.78 % Expected term in years 6.03 5.20 to 6.54 Volatility 158.35 % 79.14% to 191.71 % Dividend rate 0.0 % 0.0 % Shares 4,162,000 Fair Value per share $ 0.27 On September 12, 2022, Committee September 13, 2022 90 No three six September 30, 2022. Assumption: Pre-modification Post-modification Market price per share $ 0.2052 $ 0.2052 Exercise price per share $ 1.27 $ 1.27 Risk-free interest rate 2.62 % 3.17 % Remaining contractual term in years 0.003 0.249 Volatility 138.31 % 412.67 % Dividend rate 0.0 % 0.0 % Number of option shares 1,322,118 1,322,118 Weighted average fair value per share $ 0.00 $ 0.08 On December 12, 2022, March 31, 2023. No three December 31, 2022, nine December 31, 2022. Assumption: Pre-modification Post-modification Market price per share $ 0.1190 $ 0.1190 Exercise price per share $ 1.27 $ 1.27 Risk-free interest rate 3.86 % 4.38 % Remaining contractual term in years 0.0 0.299 Volatility 92.75 % 99.54 % Dividend rate 0.0 % 0.0 % Number of option shares 1,322,118 1,322,118 Weighted average fair value per share $ 0.00 $ 0.0001 During the nine December 31, 2022, 2019 December 31, 2022, 2016 2016 2019 2019 2016 Leases, Right-of-use Assets and Operating Lease Obligations We account for our leases following the guidance of Accounting Standards Update ( ASU No. 2016 02, Leases (Topic 842 ASU 2016 02 2016 02 Right-of-use assets not may Lease expense for minimum lease payments is recognized on a straight-line basis over the lease term. Short-term leases, defined as leases that have a lease term of 12 not Financing leases, formerly referred to as capitalized leases, are treated similarly to operating leases except that the asset subject to the lease is included in the appropriate fixed asset category, rather than recorded as a Right-of-use asset, and depreciated over its estimated useful life, or lease term, if shorter. Refer to Note 10, Commitments and Contingencies, 842 Concentrations of Credit Risk Financial instruments, which potentially subject us to concentrations of credit risk, consist of cash and cash equivalents. Our investment policies limit any such investments to short-term, low-risk instruments. We deposit cash and cash equivalents with quality financial institutions which are insured to the maximum of federal limitations. Balances in these accounts may Comprehensive Loss We have no Loss per Common Share Basic net loss attributable to common stockholders per share of common stock excludes the effect of dilution and has historically been computed by dividing net loss increased by the accrual of dividends on outstanding shares of our Series B 10% Series B Preferred third 2022, As a result of our net loss for all periods presented and the conversion of all series of our preferred stock prior to December 31, 2021, December 31, 2022 2021 At December 31, At December 31, 2022 2021 Outstanding options under the Company's Amended and Restated 2016 (formerly 2008) Stock Incentive Plan and 2019 Omnibus Equity Incentive Plan 22,567,914 15,903,139 Outstanding warrants to purchase common stock 2,397,594 9,307,858 Total 24,965,508 25,210,997 Fair Value Measurements We do not December 31, 2022 March 31, 2022, 1 December 31, 2022 March 31, 2022. Warrants Issued in Connection with Equity Financing We evaluate the appropriate balance sheet classification of warrants we issue as either equity or as a derivative liability. In accordance with ASC 815 40, Derivatives and Hedging-Contracts in the Entity s Own Equity ASC 815 40 not not 480, Distinguishing Liabilities from Equity, 815 40, December 31, 2022 March 31, 2022, Recent Accounting Pronouncements We believe the following recent accounting pronouncement is of significance or potential significance to the Company. In August 2020, FASB 2020 06, Debt Debt with Conversion and Other Options (Subtopic 470 20 Contracts in Entity s Own Equity (Subtopic 815 40 s Own Equity ASU 2020 06 The guidance in ASU 2020 06 470 20, Debt: Debt with Conversion and Other Options 470 20 not In addition, the amendments revise the scope exception from derivative accounting in ASC 815 40 not The amendments in ASU 2020 06 260, Earnings Per Share EPS may The amendments in ASU 2020 06 April 1, 2024. not 2020 06 Other accounting standards that have been issued or proposed by the FASB or other standard-setting bodies that do not not |