Certification Pursuant to 18 U.S.C. 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002; provided by the Chief Executive Officer and Chief Financial Officer, based on each such officer's knowledge and belief.
The undersigned officers of Nuveen Municipal High Income Opportunity Fund 2 (the “Fund”), certify that, to the best of each such officer's knowledge and belief:
| 1. | The Form N-CSR of the Fund for the period ended April 30, 2011 (the “Report”) fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and |
| 2. | The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Fund. |
Date: July 8, 2011
/s/ Gifford R. Zimmerman
Gifford R. Zimmerman
Chief Administrative Officer
(principal executive officer)
/s/ Stephen D. Foy
Stephen D. Foy
Vice President, Controller
(principal financial officer)