EMI Holding 10-Q 6 Jun 16 2016 Q1 Quarterly report Financial data

Document and Entity Information

Document and Entity Information - shares	3 Months Ended
	Mar. 31, 2016	May. 31, 2016
Document And Entity Information
Entity Registrant Name	EMMAUS LIFE SCIENCES, INC.
Entity Central Index Key	1,420,031
Document Type	10-Q
Document Period End Date	Mar. 31, 2016
Amendment Flag	false
Current Fiscal Year End Date	--12-31
Entity a Well-known Seasoned Issuer	No
Entity a Voluntary Filer	No
Entity's Reporting Status Current	Yes
Entity Filer Category	Smaller Reporting Company
Entity Common Stock, Shares Outstanding		28,565,344
Document Fiscal Period Focus	Q1
Document Fiscal Year Focus	2,016

CONSOLIDATED BALANCE SHEETS (Un

CONSOLIDATED BALANCE SHEETS (Unaudited) - USD ($)	Mar. 31, 2016	Dec. 31, 2015
CURRENT ASSETS
Cash and cash equivalents	$ 323,938	$ 472,341
Accounts receivable	61,314	101,639
Inventories, net	302,030	219,163
Marketable securities, pledged to creditor	244,920	219,015
Prepaid expenses and other current assets	96,917	131,113
Total current assets	1,029,119	1,143,271
PROPERTY AND EQUIPMENT, net	55,079	58,227
OTHER ASSETS
Deposits	260,727	275,500
Total other assets	260,727	275,500
Total Assets	1,344,925	1,476,998
CURRENT LIABILITIES
Accounts payable and accrued expenses	3,943,670	3,780,494
Other current liability	67,589	88,331
Notes payable, net	4,780,349	4,656,749
Notes payable to related parties, net	2,961,838	2,766,304
Convertible notes payable, net	6,455,879	6,000,347
Convertible notes payable to related parties, net	254,000	298,000
Total current liabilities	18,463,325	17,590,225
LONG-TERM LIABILITIES
Deferred rent	59,555	59,886
Warrant derivative liabilities	8,726,000	7,863,000
Convertible notes payable, net	4,127,015	4,206,873
Convertible notes payable to related parties, net	320,000	320,000
Total long-term liabilities	13,232,570	12,449,759
Total Liabilities	$ 31,695,895	$ 30,039,984
COMMITMENTS AND CONTINGENCIES
STOCKHOLDERS' DEFICIT
Preferred stock - par value $0.001 per share, 20,000,000 shares authorized, none issued and outstanding
Common stock - par value $0.001 per share, 100,000,000 shares authorized, 28,563,478 and 28,163,478 shares issued and outstanding at March 31, 2016 and December 31, 2015, respectively	$ 28,563	$ 28,163
Additional paid-in capital	59,143,596	56,508,984
Accumulated other comprehensive loss	(281,415)	(318,324)
Accumulated deficit	(89,241,714)	(84,781,809)
Total Stockholders' Deficit	(30,350,970)	(28,562,986)
Total Liabilities & Stockholders' Deficit	$ 1,344,925	$ 1,476,998

CONSOLIDATED BALANCE SHEETS (U3

CONSOLIDATED BALANCE SHEETS (Unaudited) (Parenthetical) - $ / shares	Mar. 31, 2016	Dec. 31, 2015
Principal Outstanding, Current
Preferred stock, par (in dollars per share)	$ 0.001	$ 0.001
Preferred stock, authorized	20,000,000	20,000,000
Common stock, par (in dollars per share)	$ 0.001	$ 0.001
Common stock, authorized	100,000,000	100,000,000
Common stock, issued	28,563,478	28,163,478
Common stock, outstanding	28,563,478	28,163,478

CONSOLIDATED STATEMENTS OF COMP

CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS (Unaudited) - USD ($)	3 Months Ended
	Mar. 31, 2016	Mar. 31, 2015
Income Statement [Abstract]
REVENUES, Net	$ 79,399	$ 96,759
COST OF GOODS SOLD	28,066	49,990
GROSS PROFIT	51,333	46,769
OPERATING EXPENSES
Research and development	502,301	244,118
Selling	93,580	157,186
General and administrative	2,292,922	2,854,342
[OperatingExpenses]	2,888,803	3,255,646
LOSS FROM OPERATIONS	(2,837,470)	(3,208,877)
OTHER INCOME (EXPENSE)
Change in fair value of liability classified warrants		186,000
Change in fair value of warrant derivative liabilities	(863,000)	382,000
Interest and other income (loss)	(25,833)	43,538
Interest expense	(731,202)	(644,497)
[NonoperatingIncomeExpense]	(1,620,035)	(32,959)
LOSS BEFORE INCOME TAXES	(4,457,505)	(3,241,836)
INCOME TAXES	2,400	2,200
NET LOSS	(4,459,905)	(3,244,036)
COMPONENTS OF OTHER COMPREHENSIVE LOSS
Unrealized holding gian (loss) on securities available-for-sale	25,905	(133,026)
Unrealized foreign currency translation effect	11,004	915
[OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent]	36,909	(132,111)
COMPREHENSIVE LOSS	$ (4,422,996)	$ (3,376,147)
NET LOSS PER COMMON SHARE (in dollars per share)	$ (0.16)	$ (0.11)
WEIGHTED AVERAGE COMMON SHARES OUTSTANDING (in shares)	28,465,798	30,581,171

CONSOLIDATED STATEMENT OF CHANG

CONSOLIDATED STATEMENT OF CHANGES IN STOCKHOLDERS' DEFICIT (Unaudited) - 3 months ended Mar. 31, 2016 - USD ($)	Common Stock [Member]	Additional Paid-in Capital [Member]	Accumulated Other Comprehensive Loss [Member]	Accumulated Deficit [Member]	Total
Balance, beginning at Dec. 31, 2015	$ 28,163	$ 56,508,984	$ (318,324)	$ (84,781,809)	$ (28,562,986)
Balance, beginning (in shares) at Dec. 31, 2015	28,163,478
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Stock issued for cash	$ 400	1,799,599			1,799,999
Stock issued for cash (in shares)	400,000
Beneficial conversion feature relating to convertible and promissory notes payable		294,497			294,497
Share-based compensation		540,516			540,516
Unrealized loss on marketable securities, net of tax			25,905		25,905
Foreign currency translation effect			11,004		11,004
Net loss				(4,459,905)	(4,459,905)
Balance, ending at Mar. 31, 2016	$ 28,563	$ 59,143,596	$ (281,415)	$ (89,241,714)	$ (30,350,970)
Balance, ending (in shares) at Mar. 31, 2016	28,563,478

CONSOLIDATED STATEMENT OF CASH

CONSOLIDATED STATEMENT OF CASH FLOWS (Unaudited) - USD ($)	3 Months Ended
	Mar. 31, 2016	Mar. 31, 2015
CASH FLOWS FROM OPERATING ACTIVITIES
Net loss	$ (4,459,905)	$ (3,244,036)
Adjustments to reconcile net loss to net cash flows used in operating activities
Depreciation and amortization	3,668	59,094
Interest expense accrued from discount of convertible notes	238,130	339,006
Foreign exchange adjustments on convertible notes and notes payable	142,760	14,523
Share-based compensation	540,516	1,280,790
Change in fair value of liability classified warrants		(186,000)
Change in fair value of warrant derivative liabilities	863,000	(382,000)
Net changes in operating assets and liabilities
Accounts receivable	43,136	27,918
Inventories	(78,021)	(16,823)
Prepaid expenses and other current assets	57,246	21,283
Deposits	16,859	9,196
Accounts payable and accrued expenses	338,171	803,645
Other current liability	(65,000)
Deferred rent	(424)	44,957
Net cash flows used in operating activities	(2,359,864)	(1,228,447)
CASH FLOWS FROM INVESTING ACTIVITIES
Purchases of property and equipment		(1,467)
Net cash flows used in investing activities		(1,467)
CASH FLOWS FROM FINANCING ACTIVITIES
Proceeds from notes payable issued	400,000	698,783
Proceeds from convertible notes payable issued	279,950	$ 200,000
Payments of notes payable	(228,000)
Payments of convertible notes payable	$ (44,000)
Proceeds from exercise of warrants		$ 102,885
Proceeds from issuance of common stock	$ 1,799,999
Net cash flows from financing activities	2,207,949	$ 1,001,668
Effect of exchange rate changes on cash	3,512	287
Net decrease in cash and cash equivalents	(148,403)	(227,959)
Cash and cash equivalents, beginning of period	472,341	556,318
Cash and cash equivalents, end of period	323,938	328,359
SUPPLEMENTAL DISCLOSURES OF CASH FLOW ACTIVITIES
Interest paid	146,727	62,240
Income taxes paid	$ 2,400	$ 2,200

BASIS OF PRESENTATION

BASIS OF PRESENTATION	3 Months Ended
	Mar. 31, 2016
Basis Of Presentation
BASIS OF PRESENTATION	NOTE 1 — BASIS OF PRESENTATION The accompanying unaudited consolidated interim financial statements of Emmaus Life Sciences, Inc. and subsidiaries (the “Company” or “Emmaus”) The preparation of the consolidated financial statements requires the use of management estimates. Actual results could differ materially from those estimates. Correction of immaterial errors Pursuant to the guidance of Staff Accounting Bulletin (“SAB”) No. 99, Materiality, Considering the Effects of Prior Year Misstatements when Quantifying Misstatements in Current Year Financial Statements A reconciliation of the effects of the adjustment to the previously reported consolidated balance sheet at March 31, 2015 follows: As Previously Adjustment As Revised As of March 31, 2015 Additional paid in capital 53,216,812 290,720 53,507,532 Accumulated deficit (75,037,152 ) (290,720 ) (75,327,872 ) A reconciliation of the effect of the adjustment to the previously reported consolidated statement of comprehensive loss for the three months ended March 31, 2015 follows: As Previously Adjustment As Revised For Three Months Ended March 31, 2015 General and administrative 3,214,796 (360,454 ) 2,854,342 Loss from operations (3,569,331 ) 360,454 (3,208,877 ) Loss before income taxes (3,602,290 ) 360,454 (3,241,836 ) A reconciliation of the effect of the adjustments to the previously reported consolidated statement of cash flows for the three months ended March 31, 2015 follows: As Previously Adjustment As Revised For Three Months Ended March 31, 2015 Net loss (3,604,490 ) 360,454 (3,244,036 ) Share-based compensation 1,641,244 (360,454 ) 1,280,790

SUMMARY OF SIGNIFICANT ACCOUNTI

SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES	3 Months Ended
	Mar. 31, 2016
Accounting Policies [Abstract]
SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES	NOTE 2 — SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES Refer to the Company’s Annual Report for a summary of significant accounting policies. There have been no material changes to our significant accounting policies during the three months ended March 31, 2016. Below are disclosures of certain interim balances, transactions, and significant assumptions used in computing fair value as of and for the three months ended March 31, 2016 and comparative amounts from the prior fiscal periods: Inventories — Inventory by category March 31, 2016 December 31, 2015 Work-in-process $ 161,194 $ 45,355 Finished goods 140,836 173,808 $ 302,030 $ 219,163 Advertising cost — Marketable securities — As of March 31, 2016, 39,250 shares of CellSeed stock are pledged to secure a Prepaid expenses and other current assets March 31, 2016 December 31, 2015 Prepaid insurance $ 67,948 $ 97,708 Other prepaid expenses and current assets 28,969 33,405 $ 96,917 $ 131,113 Fair value measurements Period ended Liability Classified Warrants—Stock Purchase Warrants March 31, 2016 December 31, 2015 Balance, beginning of period $ — $ 3,206,000 Reclassification to warrant derivative liabilities — (2,545,000 ) Change in fair value included in the statements of comprehensive loss — (661,000 ) Balance, end of period $ — $ — Period ended Warrant Derivative Liabilities—Stock Purchase Warrants March 31, 2016 December 31, 2015 Balance, beginning of period $ 7,863,000 $ 6,520,000 Reclassification from liability classified warrants — 2,545,000 Change in fair value included in the statements of comprehensive loss 863,000 (1,202,000 ) Balance, end of period $ 8,726,000 $ 7,863,000 The value of the liability classified warrants, the value of warrant derivative liability and the change in fair value of the liability classified warrants and warrant derivative liability were determined using a Binomial Monte-Carlo Cliquet (aka “Ratchet”) Option Pricing Model. The model is similar to traditional Black-Scholes-type option pricing models, except that the exercise price resets at certain dates in the future. T March 31, 2016 December 31, 2015 Initial Value Stock price $ 5.00 $ 4.70 $ 3.60 Risk-free interest rate 0.79 % 1.23 % 1.72 % Expected volatility (peer group) 69.20 % 64.10 % 72.40 % Expected life (in years) 2.45 2.70 5.00 Number outstanding 3,320,501 3,320,501 3,320,501 Balance, end of period: Liability classified warrants $ — $ — $ 7,541,000 Warrant derivative liabilities $ 8,726,000 $ 7,863,000 $ — Debt and related party debt Type of Loan Term of Stated Original Conversion Beneficial Warrants Exercise Warrant Effective 2015 convertible notes payable Due on demand ~ 2 years 10 % 4,051,022 $3.50~ $4.50 1,388,201 110,417 $ 4.90 220,071 14% ~ 109% 2016 convertible notes payable Due on demand ~ 2 years 10 % 1,028,959 $3.60~ $4.50 294,497 — — — 14% ~ 49% Total $ 5,079,981 $ 1,682,698 110,417 $ 220,071 Related party notes are disclosed as separate line items in the Company’s balance sheet presentation. Net loss per share Recent accounting pronouncements In February 2016, the FASB issued ASU No. 2016-02, Leases. The amendments in this Update require a lessee to recognize in the statement of financial position a liability to make lease payments (the lease liability) and a right-of-use asset representing its right to use the underlying asset for the lease term for all leases with terms greater than twelve months. For leases less than twelve months, an entity is permitted to make an accounting policy election by class of underlying asset not to recognize lease assets and lease liabilities. If a lessee makes this election, it should recognize lease expense for such leases generally on a straight-line basis over the lease term. The amendments in this Update are effective for the Company for fiscal years beginning after December 15, 2018, including interim periods within those years, with early adoption permitted. The Company is currently in the process of evaluating the impact of adoption of the amendments in this Update on the Company’s consolidated financial position and results of operations; however, adoption of the amendments in this Update are expected to be material for most entities who have a material lease with a term of greater than twelve months. In March 2016, the FASB issued ASU 2016-09, Compensation — Stock Compensation (Topic 718): Improvements to Employee Share-Based Payment Accounting. The amendments in this Update simplify the accounting for share-based payment award transactions including: income tax consequences, classification of awards as either equity or liabilities and classification on the statement of cash flows. This Update is effective for annual periods beginning after December 15, 2016, including interim periods within those annual periods. Early adoption is permitted. The Company is currently in the process of evaluating this new Update.

PROPERTY AND EQUIPMENT

PROPERTY AND EQUIPMENT	3 Months Ended
	Mar. 31, 2016
Property, Plant and Equipment [Abstract]
PROPERTY AND EQUIPMENT	NOTE 3 — PROPERTY AND EQUIPMENT Property and equipment consisted of the following at: March 31, 2016 December 31, 2015 Equipment $ 165,196 $ 164,931 Leasehold improvements 31,123 30,579 Furniture and fixtures 74,868 74,682 Sub total 271,187 270,192 Less: accumulated depreciation (216,108 ) (211,965 ) Total $ 55,079 $ 58,227 During the three months ended March 31, 2016 and 2015, depreciation expense was $3,668 and $5,523, respectively.

INTANGIBLE ASSETS

INTANGIBLE ASSETS	3 Months Ended
	Mar. 31, 2016
Goodwill and Intangible Assets Disclosure [Abstract]
INTANGIBLE ASSETS	NOTE 4 — INTANGIBLE ASSETS Intangible assets, related to license fees and patent filing costs associated with March 31, 2016 December 31, 2015 License fees and patent filing costs $ 500,000 $ 2,000,000 Less: accumulated amortization (500,000 ) (1,321,429 ) Less: intangible asset impairment — (678,571 ) Total $ — $ — During the three months ended March 31, 2016 and 2015, amortization expense was $0 and $53,571, respectively.

ACCOUNTS PAYABLE AND ACCRUED EX

ACCOUNTS PAYABLE AND ACCRUED EXPENSES	3 Months Ended
	Mar. 31, 2016
Payables and Accruals [Abstract]
ACCOUNTS PAYABLE AND ACCRUED EXPENSES	NOTE 5 — ACCOUNTS PAYABLE AND ACCRUED EXPENSES Accounts payable and accrued expenses consisted of the following at: March 31, 2016 December 31, 2015 Accounts payable Clinical and regulatory expenses $ 145,003 $ 322,193 Legal expenses 209,196 242,384 Other vendors 1,116,151 959,333 Total accounts payable 1,470,350 1,523,910 Accrued interest payable, related parties 126,214 176,940 Accrued interest payable 1,853,934 1,586,472 Accrued expenses 201,506 201,506 Deferred salary 291,666 291,666 Total accounts payable and accrued expenses $ 3,943,670 $ 3,780,494

NOTES PAYABLE

NOTES PAYABLE	3 Months Ended
	Mar. 31, 2016
Debt Disclosure [Abstract]
NOTES PAYABLE	NOTE 6 — NOTES PAYABLE Notes payable consisted of the following at March 31, 2016 and December 31, 2015: Year Interest Rate Term of Notes Conversion Principal Discount Carrying Shares Principal Discount Amount Carrying Shares Notes payable 2013 10% Due on demand — $ 890,000 $ — $ 890,000 — $ 830,000 $ — $ 830,000 — 2014 11% Due on demand ~ 2 years — 613,614 — 613,614 — 1,446,950 — 1,446,950 — 2015 11% Due on demand ~ 2 years — 2,443,400 — 2,443,400 — 2,379,799 — 2,379,799 — 2016 11% Due on demand — 833,335 — 833,335 — — — — — $ 4,780,349 $ — $ 4,780,349 — $ 4,656,749 $ — $ 4,656,749 — Current $ 4,780,349 $ — $ 4,780,349 — $ 4,656,749 $ — $ 4,656,749 — Non-current $ — $ — $ — — $ — $ — $ — — Notes payable - related party 2012 8% ~ 10% Due on demand — $ 626,730 $ — $ 626,730 — $ 626,730 $ — $ 626,730 — 2013 8% Due on demand — 50,000 — 50,000 — 50,000 — 50,000 — 2014 11% Due on demand ~ 2 years — — — — — 240,308 — 240,308 — 2015 10% ~ 11% Due on demand ~ 2 years — 1,621,265 — 1,621,265 — 1,849,266 — 1,849,266 — 2016 11% Due on demand ~ 2 years — 663,843 663,843 — — — — — $ 2,961,838 $ — $ 2,961,838 — $ 2,766,304 $ — $ 2,766,304 — Current $ 2,961,838 $ — $ 2,961,838 — $ 2,766,304 $ — $ 2,766,304 — Non-current $ — $ — $ — — $ — $ — $ — — Convertible notes payable 2010 6% 5 years $3.05 $ 2,000 $ — $ 2,000 656 $ 2,000 $ — $ 2,000 656 2011 10% 5 years $3.05 500,000 — 500,000 165,173 500,000 — 500,000 163,809 2013 10% 2 years $3.60 200,257 — 200,257 71,446 525,257 — 525,257 185,553 2014 10% Due on demand ~ 2 years $3.05~$7.00 4,403,470 236,542 4,166,928 1,151,351 4,378,563 353,700 4,024,863 1,120,470 2015 10% Due on demand ~ 2 years $3.50~$7.00 5,384,340 420,490 4,963,850 1,462,149 5,681,166 526,066 5,155,100 1,517,996 2016 10% Due on demand ~ 2 years $3.60~$4.50 1,028,959 279,100 749,859 272,872 — — — — $ 11,519,026 $ 936,132 $ 10,582,894 3,123,647 $ 11,086,986 $ 879,766 $ 10,207,220 2,988,484 Current $ 6,913,862 $ 457,983 $ 6,455,879 1,915,803 $ 6,358,698 $ 358,351 $ 6,000,347 1,762,849 Non-current $ 4,605,164 $ 478,149 $ 4,127,015 1,207,844 $ 4,728,288 $ 521,415 $ 4,206,873 1,225,635 Convertible notes payable - related party 2012 10% Due on demand $3.30 $ 254,000 $ — $ 254,000 88,733 $ 298,000 $ — $ 298,000 108,505 2015 10% 2 years $4.50 320,000 — 320,000 74,127 320,000 — 320,000 72,354 $ 574,000 $ — $ 574,000 162,860 $ 618,000 $ — $ 618,000 180,859 Current $ 254,000 $ — $ 254,000 88,733 $ 298,000 $ — $ 298,000 108,505 Non-current $ 320,000 $ — $ 320,000 74,127 $ 320,000 $ — $ 320,000 72,354 Grand Total $ 19,835,213 $ 936,132 $ 18,899,081 3,286,507 $ 19,128,039 $ 879,766 $ 18,248,273 3,169,343 The average stated interest rate of notes payable as of March 31, 2016 and December 31, 2015 was 10%. The average effective interest rate of notes payable for each of the three-month period ended March 31, 2016 and the year ended December 31, 2015 was 23% and 23%, respectively after giving effect to discounts relating to beneficial conversion features and the fair value of warrants issued in connection with these notes. The notes payable and convertible notes payable do not have restrictive financial covenants or acceleration clauses associated with a material adverse change event. The holders of the convertible notes have the option to convert their notes into the Company’s common stock at the stated conversion price during the term of their convertible notes. Conversion prices on these convertible notes payable range from $3.05 to $3.60 per share. Certain notes with a $4.50 or a $7.00 stated conversion price in the second year of their two year term are subject to automatic conversion into shares of our common stock at a conversion price equal to 80% of the initial public offering price at the time of a qualified public offering. All due on demand notes are treated as current liabilities. Contractual principal payments due on notes payable are as follows: Year Ending at March 31, 2016 2016 $ 13,973,596 2017 5,239,167 2018 622,450 Total $ 19,835,213 The Company estimated the total fair value of any beneficial conversion feature and accompanying warrants in allocating the debt proceeds. The proceeds allocated to the beneficial conversion feature were determined by taking the estimated fair value of shares issuable under the convertible notes less the fair value of the number of shares that would be issued if the conversion rate equaled the fair value of the Company’s common stock as of the date of issuance (see Note 2). The fair value of the warrants issued in conjunction with notes was determined using the Black Scholes Merton option pricing model with the following inputs for the periods ended: March 31, 2016 December 31, 2015 Stock price $ — $ 4.50 Exercise price $ — $ 4.90 Term — 5 years Risk-free interest rate — % 1.57 % Expected dividend yield — — Expected volatility — % 67.3 % In situations where the debt included both a beneficial conversion feature and a warrant, the proceeds were allocated to the warrants and beneficial conversion feature based on their respective pro-rata fair values.

STOCKHOLDERS' DEFICIT

STOCKHOLDERS' DEFICIT	3 Months Ended
	Mar. 31, 2016
Stockholders' Equity Note [Abstract]
STOCKHOLDERS' DEFICIT	NOTE 7 — STOCKHOLDERS’ DEFICIT Private placement — The warrants issued in the Private Placement and the Broker Warrants entitle the holders thereof to purchase, at any time on or prior to September 11, 2018, shares of common stock of the Company at an exercise price of $3.50 per share. The warrants contain non-standard anti-dilution protection and, consequently, are being accounted for as liabilities, were originally recorded at fair value, and are adjusted to fair market value each reporting period. Because the shares of common stock underlying the Private Placement warrants and Broker Warrants were not effectively registered for resale by September 11, 2014, the warrant holders have an option to exercise the warrants using a cashless exercise feature. The shares have not been registered for resale as of March 31, 2016. The availability to warrant holders of the cashless exercise feature as of September 11, 2014 caused the then-outstanding 2,225,036 Private Placement warrants and Broker Warrants with fair value of $7,068,000 to be reclassified from liability classified warrants to warrant derivative liabilities and to continue to be remeasured at fair value each reporting period. On June 10, 2014, certain warrant holders exercised 1,095,465 warrants issued in the Private Placement for the exercise price of $3.50 per share, resulting in the Company receiving aggregate exercise proceeds of $3.8 million and issuing 1,095,465 shares of common stock. Prior to exercise, these Private Placement warrants were accounted for at fair value as liability classified warrants. As of June 10, 2014, immediately prior to exercise, the carrying value of these Private Placement warrants was reduced to their fair value immediately prior to exercise of $1.8 million, representing their intrinsic value, with this adjusted carrying value of $1.8 million being transferred to additional paid-in capital. Also on June 10, 2014, based on an offer made to holders of Private Placement warrants in connection with such exercises, the Company issued an aggregate of 1,095,465 replacement warrants to holders exercising Private Placement warrants, which replacement warrants have terms that are generally the same as the exercised warrants, including an expiration date of September 11, 2018 and an exercise price of $3.50 per share. The replacement warrants are treated for accounting purposes as liability classified warrants, and their issuance gave rise to a $3.5 million warrant exercise inducement expense based on their fair value as of issuance as determined using a Binomial Monte-Carlo Cliquet (aka Ratchet) Option Pricing Model. As of March 31, 2016, the fair value of these Private Placement warrants, replacement warrants, and Broker Warrants was $8,726,000 (see Note 2). For further details regarding registration rights associated with the Private Placement warrants, replacement warrants and Broker Warrants, see the Registration Rights section below in this footnote. A summary of outstanding warrants as of Three months ended Year ended Warrants outstanding, beginning of period 3,530,918 5,101,450 Granted — 110,417 Exercised — (148,256 ) Cancelled, forfeited or expired — (1,532,693 ) Warrants outstanding, end of period 3,530,918 3,530,918 A summary of outstanding warrants by year issued and exercise price as of Outstanding Exercisable Exercise Price Number of Weighted Average Weighted Total Weighted Balance 2013 $3.30 50,000 2.08 $ 3.30 50,000 $ 3.30 $3.50 2,225,036 2.45 $ 3.50 2,225,036 $ 3.50 2013 total 2,275,036 2,275,036 During 2014 $3.50 1,145,465 2.48 $ 3.50 1,145,465 $ 3.50 2014 total 1,145,465 1,145,465 During 2015 $4.90 110,417 3.93 $ 4.90 110,417 $ 4.90 Total 3,530,918 3,530,918 Stock options A summary of outstanding options as of March 31, 2016 is March 31, 2016 December 31, 2015 Number of Weighted- Number of Weighted- Options outstanding, beginning of period 4,753,335 $ 3.60 5,669,000 $ 3.68 Granted or deemed issued 300,000 $ 4.70 — $ — Exercised — — (2,000 ) $ 3.60 Cancelled, forfeited and expired (33,334 ) $ 5.10 (913,665 ) $ 4.05 Options outstanding, end of period 5,020,001 $ 3.85 4,753,335 $ 3.60 Options exercisable, end of period 4,628,112 $ 3.59 4,379,335 $ 3.60 Options available for future grant, end of period 3,979,999 4,246,665 No options were issued during the three months ended March 31, 2015. During the three months ended March 31, 2016 and 2015, the Company recognized $0.5 million and $1.3 million, respectively, of share-based compensation cost arising from stock options. As of March 31, 2016, there was $0.9 million of total unrecognized compensation cost related to unvested share-based compensation arrangements granted under the 2011 Stock Incentive Plan. That cost is expected to be recognized over the weighted average remaining period of 2.4 years. Registration rights — If the shares of common stock underlying these warrants to purchase 3,320,501 shares are not registered for resale at the time of exercise, and the registration rights described above then apply with respect to the holder of such warrants, such holder may exercise such warrants on a cashless basis. In such a cashless exercise of all the shares covered by the warrant, the warrant holder would receive a number of shares equal to the quotient of (i) the difference between the fair market value of the common stock, as defined, and the $3.50 exercise price, as adjusted, multiplied by the number of shares exercisable under the warrant, divided by (ii) the fair market value of the common stock, as defined. As of March 31, 2016, based on a fair market value of a share of the Company’s common stock of $5.00 and 3,320,501 warrants issued and outstanding and eligible for cashless exercise, the maximum number of shares the Company would be required to issue, if the warrant holders elected to exercise the cashless exercise feature with respect to all then eligible warrants, is 996,150 shares. If the fair market value of a share of the Company’s common stock were to increase by $1.00 from $5.00 to $6.00, the maximum number of shares the Company would be required to issue, if the warrant holders elected to exercise the cashless exercise feature with respect to all then eligible warrants, would increase to 1,383,542 shares as of March 31, 2016. The Company has not yet filed a registration statement with respect to the resale of the Registrable Securities because doing so is not feasible prior to the completion by the Company of its initial public offering. As previously reported, the Company has filed a draft registration statement with the SEC with respect to its proposed initial public offering. The Company believes that it has used commercially reasonable efforts to pursue an initial public offering and, accordingly, considers itself to be in compliance with its registration rights obligations notwithstanding that it has not filed a registration statement with respect to the resale of the Registrable Securities and the deadline for doing so has passed without extension.

COMMITMENTS AND CONTINGENCIES

COMMITMENTS AND CONTINGENCIES	3 Months Ended
	Mar. 31, 2016
Commitments and Contingencies Disclosure [Abstract]
COMMITMENTS AND CONTINGENCIES	NOTE 8 — COMMITMENTS AND CONTINGENCIES Distribution contract — Operating leases Future minimum lease payments under the agreements are as follows as of March 31, 2016: Year Amount 2016 (nine months) $ 415,702 2017 525,023 2018 491,240 2019 123,875 $ 1,555,840

RELATED PARTY TRANSACTIONS

RELATED PARTY TRANSACTIONS	3 Months Ended
	Mar. 31, 2016
Related Party Transactions [Abstract]
RELATED PARTY TRANSACTIONS	NOTE 9 — RELATED PARTY TRANSACTIONS On March 18, 2016, the Company issued 22,222 shares of common stock to Yutaka & Soomi Niihara, the Company’s Chairman and Chief Executive Officer for $99,999 or $4.50 per share price. The following table sets forth information relating to the Company’s loans from related persons outstanding as of March 31, 2016. Class Lender Interest Date of Term of Loan Principal Highest Amount of Amount of Conversion Shares Current, Promissory note payable to related parties: Hope Hospice (1) 8 % 1/17/2012 Due on demand $ 200,000 $ 200,000 $ — $ 8,000 $ — — Hope Hospice (1) 8 % 6/14/2012 Due on demand 200,000 200,000 — 4,000 — — Hope Hospice (1) 8 % 6/21/2012 Due on demand 100,000 100,000 — 2,000 — — Yutaka Niihara (2)(4) 10 % 12/5/2012 Due on demand 126,730 1,213,700 1,086,970 — — Hope Hospice (1) 8 % 2/11/2013 Due on demand 50,000 50,000 — 2,000 — — Hope Hospice (1) 10 % 1/7/2015 2 years (3) 100,000 100,000 — — — — James Lee (5) 10 % 1/26/2015 2 years (3) 50,000 50,000 — — — — Hope Hospice (1) 10 % 1/29/2015 2 years (3) — 30,000 30,000 2,770 — — Lan T. Tran (2) 10 % 2/9/2015 2 years (3) 10,000 10,000 — — — — Charles Stark (2) 10 % 2/10/2015 2 years (3) 10,000 10,000 — — — — IRA Service Trust Co. FBO Peter B. Ludlum (2) 10 % 2/20/2015 2 years (3) 10,000 10,000 — — — — Cuc T. Tran (5) 11 % 3/5/2015 1 year 13,161 13,161 — — — — Yutaka Niihara (2)(4) 10 % 4/7/2015 2 years (3) 302,000 500,000 198,000 15,603 — — Yutaka Niihara (2)(4) 10 % 5/21/2015 Due on demand 826,105 826,105 — 47,822 — — Masaharu & Emiko Osato (4) 11 % 12/29/2015 Due on demand 300,000 300,000 — — — — Lan Tran (2) 11 % 2/10/2016 2 years (3) 130,510 130,510 — — — — Hideki & Eiko Uehara (5) 11 % 2/15/2016 Due on demand 133,333 133,333 — — — — Masaharu & Emiko Osato (4) 11 % 2/25/2016 Due on demand 400,000 400,000 — — — — Sub total $ 2,961,838 $ 4,276,809 $ 1,314,970 $ 82,195 $ — — Current, Convertible notes payable to related parties: Yasushi Nagasaki (2) 10 % 6/29/2012 Due on demand $ 254,000 $ 388,800 $ 134,800 $ 27,824 $ 3.30 88,733 Sub total $ 254,000 $ 388,800 $ 134,800 $ 27,824 — 88,733 Non-Current, Convertible notes payable to related parties: Yutaka Niihara (2)(4) 10 % 9/29/2015 2 years $ 100,000 $ 100,000 $ — $ — $ 4.50 23,348 Charles & Kimxa Stark (2) 10 % 10/1/2015 2 years 20,000 20,000 — — 4.50 4,667 Yutaka & Soomi Niihara (2)(4) 10 % 11/16/2015 2 years 200,000 200,000 — — 4.50 46,112 Sub total $ 320,000 $ 320,000 $ — $ — $ — 74,127 Total $ 3,535,838 $ 4,985,609 $ 1,449,770 $ 110,019 $ — 162,860 (1) Dr. Niihara, a director and officer of the Company, is also the CEO of Hope Hospice. (2) Officer (3) Due on Demand (4) Director (5) Family of Officer/Director The following table sets forth information relating to the Company’s loans from related persons outstanding as of December 31, 2015. Class Lender Annual Date Term Principal Highest Amount Amount Conversion Shares Current, Notes payable to related parties: Hope Hospice(1) 8 % 1/17/2012 Due on demand $ 200,000 $ 200,000 $ — $ 8,000 $ — — Hope Hospice(1) 8 % 6/14/2012 Due on demand 200,000 200,000 — 8,000 — — Hope Hospice(1) 8 % 6/21/2012 Due on demand 100,000 100,000 — 4,000 — — Yutaka Niihara(2)(4) 10 % 12/5/2012 Due on demand 126,730 1,213,700 1,086,970 56,722 — — Hope Hospice(1) 8 % 2/11/2013 Due on demand 50,000 50,000 — 2,000 — — Lan T. Tran(2) 11 % 2/10/2014 2 years(3) 106,976 106,976 — — — — Hideki & Eiko Uehara(5) 11 % 2/15/2014 2 years 133,333 133,333 — — — — Hope Hospice(1) 10 % 1/7/2015 2 years(3) 100,000 100,000 — — — — James Lee(5) 10 % 1/26/2015 2 years(3) 50,000 50,000 — — — — Hope Hospice(1) 10 % 1/29/2015 2 years(3) 30,000 30,000 — — — — Yutaka Niihara(2)(4) 10 % 1/29/2015 Due on demand — 20,000 20,000 773 Lan T. Tran(2) 10 % 2/9/2015 2 years(3) 10,000 10,000 — — — — Charles Stark(2) 10 % 2/10/2015 2 years(3) 10,000 10,000 — — — — IRA Service Trust Co. FBO Peter B. Ludlum(2) 10 % 2/20/2015 2 years(3) 10,000 10,000 — — — — Cuc T. Tran(5) 11 % 3/5/2015 1 year 13,161 13,161 — — — — Yutaka Niihara(2)(4) 10 % 4/7/2015 2 years(3) 500,000 500,000 — — — — Yutaka Niihara(2)(4) 10 % 5/21/2015 Due on demand 826,105 826,105 — — — — Masaharu & Emiko Osato(4) 11 % 12/29/2015 Due on demand 300,000 300,000 — — — — Sub total $ 2,766,304 $ 3,873,275 $ 1,106,970 $ 79,495 $ — — Current, Convertible notes payable to related parties: Yasushi Nagasaki(2) 10 % 6/29/2012 Due on demand $ 298,000 $ 388,800 $ 90,800 $ — $ 3.30 108,505 Sub total $ 298,000 $ 388,800 $ 90,800 $ — $ — 108,505 Non-Current, convertible notes payable to related parties: Yutaka Niihara(2)(4) 10 % 9/29/2015 2 years $ 100,000 $ 100,000 $ — $ — $ 4.50 22,794 Charles & Kimxa Stark(2) 10 % 10/1/2015 2 years 20,000 20,000 4.50 4,556 Yutaka & Soomi Niihara(2)(4) 10 % 11/16/2015 2 years 200,000 200,000 4.50 45,004 Sub total 320,000 320,000 $ — $ — $ — 72,354 Total $ 3,384,304 $ 4,582,075 $ 1,197,770 $ — $ — 180,859 (1) Dr. Niihara, a director and officer of the Company, is also the CEO of Hope Hospice. (2) Officer (3) Due on Demand (4) Director (5) Family of Officer/Director

GEOGRAPHIC INFORMATION

GEOGRAPHIC INFORMATION	3 Months Ended
	Mar. 31, 2016
Segment Reporting [Abstract]
GEOGRAPHIC INFORMATION	NOTE 10 — GEOGRAPHIC INFORMATION For the three months ended March 31, 2016 and 2015, the Company earned revenue from countries outside of the United States as outlined in the table below: Country Revenues for % of total revenue for the Revenues for the % of total revenue for the Japan $ 51,074 64 % $ 42,743 44 % Taiwan 25,211 32 % 42,613 44 % The Company did not have any significant currency translation or foreign transaction adjustments during the three months ended March 31, 2016 and 2015.

SUBSEQUENT EVENTS

SUBSEQUENT EVENTS	3 Months Ended
	Mar. 31, 2016
Subsequent Events [Abstract]
SUBSEQUENT EVENTS	NOTE 11 — SUBSEQUENT EVENTS Subsequent to March 31, 2016, the Company issued the following: Notes issued after March 31, 2016 Loan Principal Outstanding Annual Interest Rate Term of Notes Conversion Price Convertible notes (1) $ 210,160 10.00 % 2 years $ 4.50 Promissory notes 550,000 11.00 % Due on demand - 6 months — Promissory notes — related party 409,700 10.00 % 2 years (Due on demand) — $ 1,169,860 (1) In April and May of 2016, the Company entered into secured loan agreements, pursuant to which it borrowed an aggregate amount of $1,295,000 at a fixed interest rate of 10% per annum. These loans will mature on the earlier of the closing of a new debt financing (subject to certain exceptions, including refinancings of the Company’s outstanding convertible notes) or May 1, 2017. These loans are secured by all personal property of the Company and are personally guaranteed by Dr. Niihara and secured by certain of his real property. Furthermore, the loan agreements contain certain negative covenants including restrictions on the Company’s ability to (1) acquire material assets outside of the ordinary course of business, (2) sell, lease, license transfer or dispose of its personal property outside of the ordinary course of business, (3) pay or declare dividends, (4) make investments in or loans to other persons, (5) redeem or repurchase its stock, (6) make deposits or investments unless they are subject to a deposit control account, (7) incur additional indebtedness other than permitted debt, (8) make payments on subordinated obligations, (9) undergo a merger, change in control or sale of a substantial portion of its assets, or (10) use loan proceeds to make payments to its affiliates. In connection with these loans, the Company also issued its lender warrants for the purchase of 62,500 shares of the Company’s common stock at an exercise price of $4.50 per share. In addition, if these loans remain outstanding for at least 30 days during the 90-day periods ending June 30, 2016, September 30, 2016 and December 31, 2016, the Company will be obligated to issue the lender additional warrants for the purchase of 37,500, 18,750 and 18,750 shares of its common stock, respectively, for an exercise price of the lowest of the fair market value of our common stock as of the start or end of such 90-day period or the lowest public sale price of our common stock during the quarter ended on the applicable measurement date. These warrants may be exercised through a cashless feature. Secured Loans after March 31, 2016 Principal Annual Term of Loans Secured loans $ 1,295,000 10 % Earlier of closing of new debt financing or May 1, 2017 Total $ 1,295,000 On May 1, 2016, U.S. Patent No. 5,693,671, entitled “L-glutamine Therapy for SCD and Thalassemia” issued on December 2, 1997 to Niihara et al., (the “SCD Patent”) expired and subsequently, the license agreement pursuant to which the Company was permitted utilize the SCD Patent to develop a treatment approach for SCD and thalassemia using L-glutamine has terminated. Since the SCD Patent is expired, competitors with more resources than the Company may develop similar products which may subject its product to greater competition than the Company expects and reduces its ability to generate revenue from its product candidate, possibly materially. These circumstances may also impair the Company’s ability to obtain license partners or other international commercialization opportunities on terms acceptable to the Company, if at all. Although the SCD patent is expired, the Company will continue to seek market exclusivity protection for the SCD treatment by way of its orphan designation which, if the product is approved, will grant the Company seven years market exclusivity. In addition, under the Title I of the Drug Price Competition and Patent Term Resolution Act or the Hatch/Waxman Act, the Company may be eligible for three-year period market exclusivity if approved by the FDA. The FDA may not agree that the Company’s product is entitled to data exclusivity under the Hatch/Waxman Act and, if granted, data exclusivity protection under the Hatch/Waxman Act will expire three years after its product is approved. With the termination of the license agreement, the Company will no longer be bound by the terms of the agreement which include but are not limited to paying royalties. The royalties were equal to 4.5% of net sales of Licensed Products in the United States until lifetime royalty payments made to the licensor total $100,000, at which time the royalty rate will decrease to 2.5% of net sales of the Licensed Products.

SUMMARY OF SIGNIFICANT ACCOUN18

SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Policies)	3 Months Ended
	Mar. 31, 2016
Accounting Policies [Abstract]
Inventories	Inventories — Inventory by category March 31, 2016 December 31, 2015 Work-in-process $ 161,694 $ 45,355 Finished goods 140,836 173,808 $ 302,030 $ 219,163
Advertising cost	Advertising cost —
Marketable securities	Marketable securities — As of March 31, 2016, 39,250 shares of CellSeed stock are pledged to secure a
Prepaid expenses and other current assets	Prepaid expenses and other current assets March 31, 2016 December 31, 2015 Prepaid insurance $ 67,948 $ 97,708 Other prepaid expenses and current assets 28,969 33,405 $ 96,917 $ 131,113
Fair value measurements	Fair value measurements Period ended Liability Classified Warrants—Stock Purchase Warrants March 31, 2016 December 31, 2015 Balance, beginning of period $ — $ 3,206,000 Reclassification to warrant derivative liabilities — (2,545,000 ) Change in fair value included in the statements of comprehensive loss — (661,000 ) Balance, end of period $ — $ — Period ended Warrant Derivative Liabilities—Stock Purchase Warrants March 31, 2016 December 31, 2015 Balance, beginning of period $ 7,863,000 $ 6,520,000 Reclassification from liability classified warrants — 2,545,000 Change in fair value included in the statements of comprehensive loss 863,000 (1,202,000 ) Balance, end of period $ 8,726,000 $ 7,863,000 The value of the liability classified warrants, the value of warrant derivative liability and the change in fair value of the liability classified warrants and warrant derivative liability were determined using a Binomial Monte-Carlo Cliquet (aka “Ratchet”) Option Pricing Model. The model is similar to traditional Black-Scholes-type option pricing models, except that the exercise price resets at certain dates in the future. T March 31, 2016 December 31, 2015 Initial Value Stock price $ 5.00 $ 4.70 $ 3.60 Risk-free interest rate 0.79 % 1.23 % 1.72 % Expected volatility (peer group) 69.20 % 64.10 % 72.40 % Expected life (in years) 2.45 2.70 5.00 Number outstanding 3,320,501 3,320,501 3,320,501 Balance, end of period: Liability classified warrants $ — $ — $ 7,541,000 Warrant derivative liabilities $ 8,726,000 $ 7,863,000 $ —
Debt and Related Party Debt	Debt and related party debt Type of Loan Term of Stated Original Conversion Beneficial Warrants Exercise Warrant Effective 2015 convertible notes payable Due on demand ~ 2 years 10 % 4,051,022 $3.50~ $4.50 1,388,201 110,417 $ 4.90 220,071 14% ~ 109% 2016 convertible notes payable Due on demand ~ 2 years 10 % 1,028,959 $3.60~ $4.50 294,497 — — — 14% ~ 49% Total $ 5,079,981 $ 1,682,698 110,417 $ 220,071 Related party notes are disclosed as separate line items in the Company’s balance sheet presentation.
Net loss per share	Net loss per share
Recent accounting pronouncements	Recent accounting pronouncements In February 2016, the FASB issued ASU No. 2016-02, Leases. The amendments in this Update require a lessee to recognize in the statement of financial position a liability to make lease payments (the lease liability) and a right-of-use asset representing its right to use the underlying asset for the lease term for all leases with terms greater than twelve months. For leases less than twelve months, an entity is permitted to make an accounting policy election by class of underlying asset not to recognize lease assets and lease liabilities. If a lessee makes this election, it should recognize lease expense for such leases generally on a straight-line basis over the lease term. The amendments in this Update are effective for the Company for fiscal years beginning after December 15, 2018, including interim periods within those years, with early adoption permitted. The Company is currently in the process of evaluating the impact of adoption of the amendments in this Update on the Company’s consolidated financial position and results of operations; however, adoption of the amendments in this Update are expected to be material for most entities who have a material lease with a term of greater than twelve months. In March 2016, the FASB issued ASU 2016-09, Compensation — Stock Compensation (Topic 718): Improvements to Employee Share-Based Payment Accounting. The amendments in this Update simplify the accounting for share-based payment award transactions including: income tax consequences, classification of awards as either equity or liabilities and classification on the statement of cash flows. This Update is effective for annual periods beginning after December 15, 2016, including interim periods within those annual periods. Early adoption is permitted. The Company is currently in the process of evaluating this new Update.

BASIS OF PRESENTATION (Tables)

BASIS OF PRESENTATION (Tables)	3 Months Ended
	Mar. 31, 2016
Basis Of Presentation Tables
Schedule of reconciliation of the effects of the adjustments to the previously reported balance sheet	A reconciliation of the effects of the adjustment to the previously reported consolidated balance sheet at March 31, 2015 follows: As Previously Adjustment As Revised As of March 31, 2015 Additional paid in capital 53,216,812 290,720 53,507,532 Accumulated deficit (75,037,152 ) (290,720 ) (75,327,872 )
Schedule of reconciliation of the effect of the adjustments to the previously reported statement of operations	A reconciliation of the effect of the adjustment to the previously reported consolidated statement of comprehensive loss for the three months ended March 31, 2015 follows: As Previously Adjustment As Revised For Three Months Ended March 31, 2015 General and administrative 3,214,796 (360,454 ) 2,854,342 Loss from operations (3,569,331 ) 360,454 (3,208,877 ) Loss before income taxes (3,602,290 ) 360,454 (3,241,836 )
Schedule of A reconciliation of the effect of the adjustments to the previously reported statement of cash flows	A reconciliation of the effect of the adjustments to the previously reported consolidated statement of cash flows for the three months ended March 31, 2015 follows: As Previously Adjustment As Revised For Three Months Ended March 31, 2015 Net loss (3,604,490 ) 360,454 (3,244,036 ) Share-based compensation 1,641,244 (360,454 ) 1,280,790

SUMMARY OF SIGNIFICANT ACCOUN20

SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Tables)	3 Months Ended
	Mar. 31, 2016
Accounting Policies [Abstract]
Schedule of inventory	The below table presents inventory by category: Inventory by category March 31, 2016 December 31, 2015 Work-in-process $ 161,694 $ 45,355 Finished goods 140,836 173,808 $ 302,030 $ 219,163
Schedule of prepaid expenses and other current assets	Prepaid expenses and other current assets consisted of the following at March 31, 2016 and December 31, 2015: March 31, 2016 December 31, 2015 Prepaid insurance $ 67,948 $ 97,708 Other prepaid expenses and current assets 28,969 33,405 $ 96,917 $ 131,113
Schedule of changes in fair value of Level 3 liabilities	The following table presents the activity for those items measured at fair value on a recurring basis using Level 3 inputs during the three months ended March 31, 2016 and the year ended December 31, 2015: Period ended Liability Classified Warrants—Stock Purchase Warrants March 31, 2016 December 31, 2015 Balance, beginning of period $ — $ 3,206,000 Reclassification to warrant derivative liabilities — (2,545,000 ) Change in fair value included in the statements of comprehensive loss — (661,000 ) Balance, end of period $ — $ — Period ended Warrant Derivative Liabilities—Stock Purchase Warrants March 31, 2016 December 31, 2015 Balance, beginning of period $ 7,863,000 $ 6,520,000 Reclassification from liability classified warrants — 2,545,000 Change in fair value included in the statements of comprehensive loss 863,000 (1,202,000 ) Balance, end of period $ 8,726,000 $ 7,863,000
Schedule of valuation assumptions for warrants	T March 31, 2016 December 31, 2015 Initial Value Stock price $ 5.00 $ 4.70 $ 3.60 Risk-free interest rate 0.79 % 1.23 % 1.72 % Expected volatility (peer group) 69.20 % 64.10 % 72.40 % Expected life (in years) 2.45 2.70 5.00 Number outstanding 3,320,501 3,320,501 3,320,501 Balance, end of period: Liability classified warrants $ — $ — $ 7,541,000 Warrant derivative liabilities $ 8,726,000 $ 7,863,000 $ —
Schedule of convertible notes payable	The following table presents the effective interest rates on the original loan principal amount for loans originated in the respective periods that either had a beneficial conversion feature or an attached warrant: Type of Loan Term of Stated Original Conversion Beneficial Warrants Exercise Warrant Effective 2015 convertible notes payable Due on demand ~ 2 years 10 % 4,051,022 $3.50~ $4.50 1,388,201 110,417 $ 4.90 220,071 14% ~ 109% 2016 convertible notes payable Due on demand ~ 2 years 10 % 1,028,959 $3.60~ $4.50 294,497 — — — 14% ~ 49% Total $ 5,079,981 $ 1,682,698 110,417 $ 220,071

PROPERTY AND EQUIPMENT (Tables)

PROPERTY AND EQUIPMENT (Tables)	3 Months Ended
	Mar. 31, 2016
Property, Plant and Equipment [Abstract]
Schedule of property and equipment	Property and equipment consisted of the following at: March 31, 2016 December 31, 2015 Equipment $ 165,196 $ 164,931 Leasehold improvements 31,123 30,579 Furniture and fixtures 74,868 74,682 Sub total 271,187 270,192 Less: accumulated depreciation (216,108 ) (211,965 ) Total $ 55,079 $ 58,227

INTANGIBLE ASSETS (Tables)

INTANGIBLE ASSETS (Tables)	3 Months Ended
	Mar. 31, 2016
Goodwill and Intangible Assets Disclosure [Abstract]
Schedule of Intangible Assets	Intangible assets, related to license fees and patent filing costs associated with March 31, 2016 December 31, 2015 License fees and patent filing costs $ 500,000 $ 2,000,000 Less: accumulated amortization (500,000 ) (1,321,429 ) Less: intangible asset impairment — (678,571 ) Total $ — $ —

ACCOUNTS PAYABLE AND ACCRUED 23

ACCOUNTS PAYABLE AND ACCRUED EXPENSES (Tables)	3 Months Ended
	Mar. 31, 2016
Payables and Accruals [Abstract]
Schedule of accounts payable and accrued expenses	Accounts payable and accrued expenses consisted of the following at: March 31, 2016 December 31, 2015 Accounts payable Clinical and regulatory expenses $ 145,003 $ 322,193 Legal expenses 209,196 242,384 Other vendors 1,116,151 959,333 Total accounts payable 1,470,350 1,523,910 Accrued interest payable, related parties 126,214 176,940 Accrued interest payable 1,853,934 1,586,472 Accrued expenses 201,506 201,506 Deferred salary 291,666 291,666 Total accounts payable and accrued expenses $ 3,943,670 $ 3,780,494

NOTES PAYABLE (Tables)

NOTES PAYABLE (Tables)	3 Months Ended
	Mar. 31, 2016
Debt Disclosure [Abstract]
Schedule of notes payable	Notes payable consisted of the following at March 31, 2016 and December 31, 2015: Year Interest Rate Term of Notes Conversion Principal Discount Carrying Shares Principal Discount Amount Carrying Shares Notes payable 2013 10% Due on demand — $ 890,000 $ — $ 890,000 — $ 830,000 $ — $ 830,000 — 2014 11% Due on demand ~ 2 years — 613,614 — 613,614 — 1,446,950 — 1,446,950 — 2015 11% Due on demand ~ 2 years — 2,443,400 — 2,443,400 — 2,379,799 — 2,379,799 — 2016 11% Due on demand — 833,335 — 833,335 — — — — — $ 4,780,349 $ — $ 4,780,349 — $ 4,656,749 $ — $ 4,656,749 — Current $ 4,780,349 $ — $ 4,780,349 — $ 4,656,749 $ — $ 4,656,749 — Non-current $ — $ — $ — — $ — $ — $ — — Notes payable - related party 2012 8% ~ 10% Due on demand — $ 626,730 $ — $ 626,730 — $ 626,730 $ — $ 626,730 — 2013 8% Due on demand — 50,000 — 50,000 — 50,000 — 50,000 — 2014 11% Due on demand ~ 2 years — — — — — 240,308 — 240,308 — 2015 10% ~ 11% Due on demand ~ 2 years — 1,621,265 — 1,621,265 — 1,849,266 — 1,849,266 — 2016 11% Due on demand ~ 2 years — 663,843 663,843 — — — — — $ 2,961,838 $ — $ 2,961,838 — $ 2,766,304 $ — $ 2,766,304 — Current $ 2,961,838 $ — $ 2,961,838 — $ 2,766,304 $ — $ 2,766,304 — Non-current $ — $ — $ — — $ — $ — $ — — Convertible notes payable 2010 6% 5 years $3.05 $ 2,000 $ — $ 2,000 656 $ 2,000 $ — $ 2,000 656 2011 10% 5 years $3.05 500,000 — 500,000 165,173 500,000 — 500,000 163,809 2013 10% 2 years $3.60 200,257 — 200,257 71,446 525,257 — 525,257 185,553 2014 10% Due on demand ~ 2 years $3.05~$7.00 4,403,470 236,542 4,166,928 1,151,351 4,378,563 353,700 4,024,863 1,120,470 2015 10% Due on demand ~ 2 years $3.50~$7.00 5,384,340 420,490 4,963,850 1,462,149 5,681,166 526,066 5,155,100 1,517,996 2016 10% Due on demand ~ 2 years $3.60~$4.50 1,028,959 279,100 749,859 272,872 — — — — $ 11,519,026 $ 936,132 $ 10,582,894 3,123,647 $ 11,086,986 $ 879,766 $ 10,207,220 2,988,484 Current $ 6,913,862 $ 457,983 $ 6,455,879 1,915,803 $ 6,358,698 $ 358,351 $ 6,000,347 1,762,849 Non-current $ 4,605,164 $ 478,149 $ 4,127,015 1,207,844 $ 4,728,288 $ 521,415 $ 4,206,873 1,225,635 Convertible notes payable - related party 2012 10% Due on demand $3.30 $ 254,000 $ — $ 254,000 88,733 $ 298,000 $ — $ 298,000 108,505 2015 10% 2 years $4.50 320,000 — 320,000 74,127 320,000 — 320,000 72,354 $ 574,000 $ — $ 574,000 162,860 $ 618,000 $ — $ 618,000 180,859 Current $ 254,000 $ — $ 254,000 88,733 $ 298,000 $ — $ 298,000 108,505 Non-current $ 320,000 $ — $ 320,000 74,127 $ 320,000 $ — $ 320,000 72,354 Grand Total $ 19,835,213 $ 936,132 $ 18,899,081 3,286,507 $ 19,128,039 $ 879,766 $ 18,248,273 3,169,343
Schedule of contractual principal payments of loans and notes payable	Contractual principal payments due on notes payable are as follows: Year Ending at March 31, 2016 2016 $ 13,973,596 2017 5,239,167 2018 622,450 Total $ 19,835,213
Schedule of fair value assumptions for warrants issued in conjunction with notes	The fair value of the warrants issued in conjunction with notes was determined using the Black Scholes Merton option pricing model with the following inputs for the periods ended: March 31, 2016 December 31, 2015 Stock price $ — $ 4.50 Exercise price $ — $ 4.90 Term — 5 years Risk-free interest rate — % 1.57 % Expected dividend yield — — Expected volatility — % 67.3 %

STOCKHOLDERS' EQUITY (DEFICIT)

STOCKHOLDERS' EQUITY (DEFICIT) (Tables)	3 Months Ended
	Mar. 31, 2016
Stockholders' Equity Note [Abstract]
Schedule of outstanding warrants	A summary of outstanding warrants as of Three months ended Year ended Warrants outstanding, beginning of period 3,530,918 5,101,450 Granted — 110,417 Exercised — (148,256 ) Cancelled, forfeited or expired — (1,532,693 ) Warrants outstanding, end of period 3,530,918 3,530,918
Schedule of outstanding warrants by year issued and exercise price	A summary of outstanding warrants by year issued and exercise price as of Outstanding Exercisable Exercise Price Number of Weighted Average Weighted Total Weighted Balance 2013 $3.30 50,000 2.08 $ 3.30 50,000 $ 3.30 $3.50 2,225,036 2.45 $ 3.50 2,225,036 $ 3.50 2013 total 2,275,036 2,275,036 During 2014 $3.50 1,145,465 2.48 $ 3.50 1,145,465 $ 3.50 2014 total 1,145,465 1,145,465 During 2015 $4.90 110,417 3.93 $ 4.90 110,417 $ 4.90 Total 3,530,918 3,530,918
Schedule of outstanding options	A summary of outstanding options as of March 31, 2016 is March 31, 2016 December 31, 2015 Number of Weighted- Number of Weighted- Options outstanding, beginning of period 4,753,335 $ 3.60 5,669,000 $ 3.68 Granted or deemed issued 300,000 $ 4.70 — $ — Exercised — — (2,000 ) $ 3.60 Cancelled, forfeited and expired (33,334 ) $ 5.10 (913,665 ) $ 4.05 Options outstanding, end of period 5,020,001 $ 3.85 4,753,335 $ 3.60 Options exercisable, end of period 4,628,112 $ 3.59 4,379,335 $ 3.60 Options available for future grant, end of period 3,979,999 4,246,665

COMMITMENTS AND CONTINGENCIES (

COMMITMENTS AND CONTINGENCIES (Tables)	3 Months Ended
	Mar. 31, 2016
Commitments and Contingencies Disclosure [Abstract]
Schedule of future minimum lease payments	Future minimum lease payments under the agreements are as follows as of March 31, 2016: Year Amount 2016 (nine months) $ 415,702 2017 525,023 2018 491,240 2019 123,875 $ 1,555,840

RELATED PARTY TRANSACTIONS (Tab

RELATED PARTY TRANSACTIONS (Tables)	3 Months Ended
	Mar. 31, 2016
Related Party Transactions [Abstract]
Schedule of related parties outstanding loans	The following table sets forth information relating to the Company’s loans from related persons outstanding as of March 31, 2016. Class Lender Interest Date of Term of Loan Principal Highest Amount of Amount of Conversion Shares Current, Promissory note payable to related parties: Hope Hospice (1) 8 % 1/17/2012 Due on demand $ 200,000 $ 200,000 $ — $ 8,000 $ — — Hope Hospice (1) 8 % 6/14/2012 Due on demand 200,000 200,000 — 4,000 — — Hope Hospice (1) 8 % 6/21/2012 Due on demand 100,000 100,000 — 2,000 — — Yutaka Niihara (2)(4) 10 % 12/5/2012 Due on demand 126,730 1,213,700 1,086,970 — — Hope Hospice (1) 8 % 2/11/2013 Due on demand 50,000 50,000 — 2,000 — — Hope Hospice (1) 10 % 1/7/2015 2 years (3) 100,000 100,000 — — — — James Lee (5) 10 % 1/26/2015 2 years (3) 50,000 50,000 — — — — Hope Hospice (1) 10 % 1/29/2015 2 years (3) — 30,000 30,000 2,770 — — Lan T. Tran (2) 10 % 2/9/2015 2 years (3) 10,000 10,000 — — — — Charles Stark (2) 10 % 2/10/2015 2 years (3) 10,000 10,000 — — — — IRA Service Trust Co. FBO Peter B. Ludlum (2) 10 % 2/20/2015 2 years (3) 10,000 10,000 — — — — Cuc T. Tran (5) 11 % 3/5/2015 1 year 13,161 13,161 — — — — Yutaka Niihara (2)(4) 10 % 4/7/2015 2 years (3) 302,000 500,000 198,000 15,603 — — Yutaka Niihara (2)(4) 10 % 5/21/2015 Due on demand 826,105 826,105 — 47,822 — — Masaharu & Emiko Osato (4) 11 % 12/29/2015 Due on demand 300,000 300,000 — — — — Lan Tran (2) 11 % 2/10/2016 2 years (3) 130,510 130,510 — — — — Hideki & Eiko Uehara (5) 11 % 2/15/2016 Due on demand 133,333 133,333 — — — — Masaharu & Emiko Osato (4) 11 % 2/25/2016 Due on demand 400,000 400,000 — — — — Sub total $ 2,961,838 $ 4,276,809 $ 1,314,970 $ 82,195 $ — — Current, Convertible notes payable to related parties: Yasushi Nagasaki (2) 10 % 6/29/2012 Due on demand $ 254,000 $ 388,800 $ 134,800 $ 27,824 $ 3.30 88,733 Sub total $ 254,000 $ 388,800 $ 134,800 $ 27,824 — 88,733 Non-Current, Convertible notes payable to related parties: Yutaka Niihara (2)(4) 10 % 9/29/2015 2 years $ 100,000 $ 100,000 $ — $ — $ 4.50 23,348 Charles & Kimxa Stark (2) 10 % 10/1/2015 2 years 20,000 20,000 — — 4.50 4,667 Yutaka & Soomi Niihara (2)(4) 10 % 11/16/2015 2 years 200,000 200,000 — — 4.50 46,112 Sub total $ 320,000 $ 320,000 $ — $ — $ — 74,127 Total $ 3,535,838 $ 4,985,609 $ 1,449,770 $ 110,019 $ — 162,860 (1) Dr. Niihara, a director and officer of the Company, is also the CEO of Hope Hospice. (2) Officer (3) Due on Demand (4) Director (5) Family of Officer/Director The following table sets forth information relating to the Company’s loans from related persons outstanding as of December 31, 2015. Class Lender Annual Date Term Principal Highest Amount Amount Conversion Shares Current, Notes payable to related parties: Hope Hospice(1) 8 % 1/17/2012 Due on demand $ 200,000 $ 200,000 $ — $ 8,000 $ — — Hope Hospice(1) 8 % 6/14/2012 Due on demand 200,000 200,000 — 8,000 — — Hope Hospice(1) 8 % 6/21/2012 Due on demand 100,000 100,000 — 4,000 — — Yutaka Niihara(2)(4) 10 % 12/5/2012 Due on demand 126,730 1,213,700 1,086,970 56,722 — — Hope Hospice(1) 8 % 2/11/2013 Due on demand 50,000 50,000 — 2,000 — — Lan T. Tran(2) 11 % 2/10/2014 2 years(3) 106,976 106,976 — — — — Hideki & Eiko Uehara(5) 11 % 2/15/2014 2 years 133,333 133,333 — — — — Hope Hospice(1) 10 % 1/7/2015 2 years(3) 100,000 100,000 — — — — James Lee(5) 10 % 1/26/2015 2 years(3) 50,000 50,000 — — — — Hope Hospice(1) 10 % 1/29/2015 2 years(3) 30,000 30,000 — — — — Yutaka Niihara(2)(4) 10 % 1/29/2015 Due on demand — 20,000 20,000 773 Lan T. Tran(2) 10 % 2/9/2015 2 years(3) 10,000 10,000 — — — — Charles Stark(2) 10 % 2/10/2015 2 years(3) 10,000 10,000 — — — — IRA Service Trust Co. FBO Peter B. Ludlum(2) 10 % 2/20/2015 2 years(3) 10,000 10,000 — — — — Cuc T. Tran(5) 11 % 3/5/2015 1 year 13,161 13,161 — — — — Yutaka Niihara(2)(4) 10 % 4/7/2015 2 years(3) 500,000 500,000 — — — — Yutaka Niihara(2)(4) 10 % 5/21/2015 Due on demand 826,105 826,105 — — — — Masaharu & Emiko Osato(4) 11 % 12/29/2015 Due on demand 300,000 300,000 — — — — Sub total $ 2,766,304 $ 3,873,275 $ 1,106,970 $ 79,495 $ — — Current, Convertible notes payable to related parties: Yasushi Nagasaki(2) 10 % 6/29/2012 Due on demand $ 298,000 $ 388,800 $ 90,800 $ — $ 3.30 108,505 Sub total $ 298,000 $ 388,800 $ 90,800 $ — $ — 108,505 Non-Current, convertible notes payable to related parties: Yutaka Niihara(2)(4) 10 % 9/29/2015 2 years $ 100,000 $ 100,000 $ — $ — $ 4.50 22,794 Charles & Kimxa Stark(2) 10 % 10/1/2015 2 years 20,000 20,000 4.50 4,556 Yutaka & Soomi Niihara(2)(4) 10 % 11/16/2015 2 years 200,000 200,000 4.50 45,004 Sub total 320,000 320,000 $ — $ — $ — 72,354 Total $ 3,384,304 $ 4,582,075 $ 1,197,770 $ — $ — 180,859 (1) Dr. Niihara, a director and officer of the Company, is also the CEO of Hope Hospice. (2) Officer (3) Due on Demand (4) Director (5) Family of Officer/Director

GEOGRAPHIC INFORMATION (Tables)

GEOGRAPHIC INFORMATION (Tables)	3 Months Ended
	Mar. 31, 2016
Segment Reporting [Abstract]
Schedule of revenue earned from countries outside of the United States	For the three months ended March 31, 2016 and 2015, the Company earned revenue from countries outside of the United States as outlined in the table below: Country Revenues for % of total revenue for the Revenues for the % of total revenue for the Japan $ 51,074 64 % $ 42,743 44 % Taiwan 25,211 32 % 42,613 44 %

SUBSEQUENT EVENTS (Tables)

SUBSEQUENT EVENTS (Tables)	3 Months Ended
	Mar. 31, 2016
Subsequent Events [Abstract]
Schedule of subsequent events notes payable	Subsequent to March 31, 2016, the Company issued the following: Notes issued after March 31, 2016 Loan Principal Outstanding Annual Interest Rate Term of Notes Conversion Price Convertible notes (1) $ 210,160 10.00 % 2 years $ 4.50 Promissory notes 550,000 11.00 % Due on demand - 6 months — Promissory notes — related party 409,700 10.00 % 2 years (Due on demand) — $ 1,169,860 (1) Secured Loans after March 31, 2016 Principal Annual Term of Loans Secured loans $ 1,295,000 10 % Earlier of closing of new debt financing or May 1, 2017 Total $ 1,295,000

BASIS OF PRESENTATION (Details

BASIS OF PRESENTATION (Details Narrative) - USD ($)	3 Months Ended
	Mar. 31, 2016	Mar. 31, 2015
Stock option accounting errors	$ 540,516	$ 1,280,790
Cumulative Adjustment [Member]
Stock option accounting errors		$ 360,454

BASIS OF PRESENTATION (Details)

BASIS OF PRESENTATION (Details) - USD ($)	Mar. 31, 2016	Dec. 31, 2015	Mar. 31, 2015
Additional paid in capital			$ 53,507,532
Accumulated deficit	$ (89,241,714)	$ (84,781,809)	(75,327,872)
Previously Reported [Member]
Additional paid in capital			53,216,812
Accumulated deficit			(75,037,152)
Adjustment [Member]
Additional paid in capital			290,720
Accumulated deficit			$ (290,720)

BASIS OF PRESENTATION (Detail32

BASIS OF PRESENTATION (Details 1) - USD ($)	3 Months Ended
	Mar. 31, 2016	Mar. 31, 2015
General and administrative	$ 2,292,922	$ 2,854,342
Loss from operations	(2,837,470)	(3,208,877)
Loss before income taxes	$ (4,457,505)	(3,241,836)
Previously Reported [Member]
General and administrative		3,214,796
Loss from operations		(3,569,331)
Loss before income taxes		(3,602,290)
Adjustment [Member]
General and administrative		(360,454)
Loss from operations		360,454
Loss before income taxes		$ 360,454

BASIS OF PRESENTATION (Detail33

BASIS OF PRESENTATION (Details 2) - USD ($)	3 Months Ended
	Mar. 31, 2016	Mar. 31, 2015
Net loss	$ (4,459,905)	$ (3,244,036)
Share-based compensation	$ 540,516	1,280,790
Previously Reported [Member]
Net loss		(3,604,490)
Share-based compensation		1,641,244
Adjustment [Member]
Net loss		360,454
Share-based compensation		$ (360,454)

SUMMARY OF SIGNIFICANT ACCOUN34

SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Details Narrative)	1 Months Ended	3 Months Ended
	Jan. 31, 2009USD ($)Number$ / sharesshares	Mar. 31, 2016USD ($)$ / sharesshares	Mar. 31, 2015USD ($)shares	Dec. 31, 2015$ / shares	Jul. 31, 2013USD ($)
Advertising costs | $		$ 3,939	$ 19,263
Potentially dilutive securities outstanding		11,837,427	12,838,502
Cell Seed Inc [Member]
Shares held as marketable securities		39,250
Shares originally purchased (in shares)	147,100
Investment, in dollars | $	$ 1,109,819
Investment, closing price | $ / shares		$ 6.24		$ 5.58
Convertible notes payable, carrying amount | $					$ 500,000
Available for sale securities, stock (in shares)		9,300
Available for sale securities, value | $		$ 71,517
Stock pledged against note		39,250
Cell Seed Inc [Member] | Japan, Yen
Investment, in yen | Number	100,028,000
Investment, in per share | $ / shares	$ 680
Investment, closing price | $ / shares		$ 701		$ 672

SUMMARY OF SIGNIFICANT ACCOUN35

SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Details) - USD ($)	Mar. 31, 2016	Dec. 31, 2015
Accounting Policies [Abstract]
Work-in-process	$ 161,194	$ 45,355
Finished goods	140,836	173,808
Total	$ 302,030	$ 219,163

SUMMARY OF SIGNIFICANT ACCOUN36

SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Details 1) - USD ($)	Mar. 31, 2016	Dec. 31, 2015
Accounting Policies [Abstract]
Prepaid insurance	$ 67,948	$ 97,708
Other prepaid expenses and current assets	28,969	33,405
Prepaid expenses and other current assets	$ 96,917	$ 131,113

SUMMARY OF SIGNIFICANT ACCOUN37

SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Details 2) - USD ($)	3 Months Ended	12 Months Ended
	Mar. 31, 2016	Dec. 31, 2015
Liability Classified Warrants - Stock Purchase Warrants [Member]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Balance, beginning of period		$ 3,206,000
Reclassification to warrant derivative liabilities		(2,545,000)
Change in fair value included in the statement of comprehensive loss		(661,000)
Warrant Derivative Liabilities - Stock Purchase Warrants [Member]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Balance, beginning of period	$ 7,863,000	6,520,000
Reclassification from liability classified warrants		2,545,000
Change in fair value included in the statement of comprehensive loss	863,000	(1,202,000)
Balance, end of period	$ 8,726,000	$ 7,863,000

SUMMARY OF SIGNIFICANT ACCOUN38

SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Details 3) - USD ($)	Sep. 11, 2013	Mar. 31, 2016	Dec. 31, 2015
Number outstanding		3,530,918
Warrants [Member]
Stock price	$ 3.60	$ 5	$ 4.70
Risk free interest rate	1.72%	0.79%	1.23%
Expected volatility (peer group)	72.40%	69.20%	64.10%
Expected life (in years)	5 years	2 years 5 months 12 days	2 years 8 months 12 days
Number outstanding	3,320,501	3,320,501	3,320,501
Balance, end of period:
Liability classified warrants	$ 7,541,000

SUMMARY OF SIGNIFICANT ACCOUN39

SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Details 4)	3 Months Ended
	Mar. 31, 2016USD ($)$ / shares$ / Warrantsshares
Original Loan Principal Amount	$ 5,079,981
Beneficial Conversion Discount Amount	1,682,698
Warrant FMV Discount Amount	$ 220,071
Minimum [Member]
Conversion Rate (in dollars per share) | $ / shares	$ 3.05
Maximum [Member]
Conversion Rate (in dollars per share) | $ / shares	$ 3.60
2015 Convertible Notes Payable [Member]
Term of Loans	Due on demand ~ 2 years
Stated Annual Interest Rate	10.00%
Original Loan Principal Amount	$ 4,051,022
Beneficial Conversion Discount Amount	$ 1,388,201
Issuance of warrants (in shares) | shares	110,417
Warrant FMV Discount Amount	$ 220,071
Excrcise Price (in dollars per share) | $ / Warrants	4.90
2015 Convertible Notes Payable [Member] | Minimum [Member]
Conversion Rate (in dollars per share) | $ / shares	$ 3.50
Effective Interest Rate Including Discounts	14.00%
2015 Convertible Notes Payable [Member] | Maximum [Member]
Conversion Rate (in dollars per share) | $ / shares	$ 4.50
Effective Interest Rate Including Discounts	109.00%
2016 Convertible Notes Payable [Member]
Term of Loans	Due on demand ~ 2 years
Stated Annual Interest Rate	10.00%
Original Loan Principal Amount	$ 1,028,959
Beneficial Conversion Discount Amount	$ 294,497
2016 Convertible Notes Payable [Member] | Minimum [Member]
Conversion Rate (in dollars per share) | $ / shares	$ 3.60
Effective Interest Rate Including Discounts	14.00%
2016 Convertible Notes Payable [Member] | Maximum [Member]
Conversion Rate (in dollars per share) | $ / shares	$ 4.50
Effective Interest Rate Including Discounts	49.00%

PROPERTY AND EQUIPMENT (Details

PROPERTY AND EQUIPMENT (Details Narrative) - USD ($)	3 Months Ended
	Mar. 31, 2016	Mar. 31, 2015
Property, Plant and Equipment [Abstract]
Depreciation expense	$ 3,668	$ 5,523

PROPERTY AND EQUIPMENT (Detai41

PROPERTY AND EQUIPMENT (Details) - USD ($)	Mar. 31, 2016	Dec. 31, 2015
Property and equipment
Property and equipment, gross	$ 271,187	$ 270,192
Less: accumulated depreciation	(216,108)	(211,965)
Property and equipment, net	55,079	58,227
Equipment [Member]
Property and equipment
Property and equipment, gross	165,196	164,931
Leasehold Improvements [Member]
Property and equipment
Property and equipment, gross	31,123	30,579
Furniture and Fixtures [Member]
Property and equipment
Property and equipment, gross	$ 74,868	$ 74,682

INTANGIBLE ASSETS (Details Narr

INTANGIBLE ASSETS (Details Narrative) - USD ($)	3 Months Ended
	Mar. 31, 2016	Mar. 31, 2015
Goodwill and Intangible Assets Disclosure [Abstract]
Amortization expense	$ 0	$ 53,571

INTANGIBLE ASSETS (Details)

INTANGIBLE ASSETS (Details) - USD ($)	12 Months Ended
	Dec. 31, 2015	Mar. 31, 2016
Intangible assets
License fees and patent filing costs	$ 2,000,000	$ 500,000
Less: accumulated amortization	(1,321,429)	$ (500,000)
Impairment	$ (678,571)

ACCOUNTS PAYABLE AND ACCRUED 44

ACCOUNTS PAYABLE AND ACCRUED EXPENSES (Details) - USD ($)	Mar. 31, 2016	Dec. 31, 2015
Accounts payable
Cinical and regulatory expenses	$ 145,003	$ 322,193
Legal expenses	209,196	242,384
Other vendors	1,116,151	959,333
Total accounts payable	1,470,350	1,523,910
Accrued interest payable, related parties	126,214	176,940
Accrued interest payable	1,853,934	1,586,472
Accrued expenses	201,506	201,506
Deferred salary	291,666	291,666
Total accounts payable and accrued expenses	$ 3,943,670	$ 3,780,494

NOTES PAYABLE (Details Narrativ

NOTES PAYABLE (Details Narrative) - $ / shares	Mar. 31, 2016	Dec. 31, 2015
Average stated interest rate	10.00%	10.00%
Average effective interest rate	23.00%	23.00%
Convertible notes payable [Member]
Mandatory conversion - initial public offering price (percent)	80.00%
Minimum [Member]
Conversion price	$ 3.05
Minimum [Member] | Convertible notes payable [Member]
Conversion price	4.50
Maximum [Member]
Conversion price	3.60
Maximum [Member] | Convertible notes payable [Member]
Conversion price	$ 7

NOTES PAYABLE (Details)

NOTES PAYABLE (Details) - USD ($)	3 Months Ended	12 Months Ended
	Mar. 31, 2016	Dec. 31, 2015
Principal Outstanding	$ 19,835,213	$ 19,128,039
Carrying Amount	18,899,081	18,248,273
Notes payable, Current	$ 4,780,349	$ 4,656,749
Minimum [Member]
Conversion price	$ 3.05
Maximum [Member]
Conversion price	$ 3.60
2013 Notes payable [Member]
Interest rate	10.00%	10.00%
Term of Notes	Due on demand
Principal Outstanding	$ 890,000	$ 830,000
Carrying Amount	$ 890,000	$ 830,000
2014 Notes payable [Member]
Interest rate	11.00%	11.00%
Term of Notes	Due on demand ~ 2 years
Principal Outstanding	$ 613,614	$ 1,446,950
Carrying Amount	$ 613,614	$ 1,446,950
2015 Notes payable [Member]
Interest rate	11.00%	11.00%
Term of Notes	Due on demand ~ 2 years
Principal Outstanding	$ 2,443,400	$ 2,379,799
Carrying Amount	$ 2,443,400	2,379,799
2016 Notes payable [Member]
Interest rate	11.00%
Term of Notes	Due on demand
Principal Outstanding	$ 833,335
Carrying Amount	833,335
Notes Payable [Member]
Principal Outstanding	4,780,349	4,656,749
Carrying Amount	4,780,349	4,656,749
Principal Outstanding, Current	4,780,349	4,656,749
Notes payable, Current	$ 4,780,349	4,656,749
2012 Notes payable - related party [Member]
Term of Notes	Due on demand
Principal Outstanding	$ 626,730	626,730
Carrying Amount	$ 626,730	$ 626,730
2012 Notes payable - related party [Member] | Minimum [Member]
Interest rate	8.00%
2012 Notes payable - related party [Member] | Maximum [Member]
Interest rate	10.00%
2013 Notes payable - related party [Member]
Interest rate	8.00%	8.00%
Term of Notes	Due on demand
Principal Outstanding	$ 50,000	$ 50,000
Carrying Amount	$ 50,000	$ 50,000
2014 Notes payable - related party [Member]
Interest rate		11.00%
Term of Notes		Due on demand ~ 2 years
Principal Outstanding		$ 240,308
Carrying Amount		240,308
2015 Notes payable - related party [Member]
Term of Notes	Due on demand ~ 2 years
Principal Outstanding	$ 1,621,265	1,849,266
Carrying Amount	$ 1,621,265	1,849,266
2015 Notes payable - related party [Member] | Minimum [Member]
Interest rate	10.00%
2015 Notes payable - related party [Member] | Maximum [Member]
Interest rate	11.00%
2016 Notes payable - related party [Member]
Interest rate	11.00%
Term of Notes	Due on demand ~ 2 years
Principal Outstanding	$ 663,843
Carrying Amount	663,843
Notes payable - related party [Member]
Principal Outstanding	2,961,838	2,766,304
Carrying Amount	2,961,838	2,766,304
Principal Outstanding, Current	$ 2,961,838	$ 2,766,304

NOTES PAYABLE (Details 1)

NOTES PAYABLE (Details 1)	3 Months Ended	12 Months Ended
	Mar. 31, 2016USD ($)sharesNumber$ / shares	Dec. 31, 2015USD ($)sharesNumber$ / shares
Principal Outstanding	$ 19,835,213	$ 19,128,039
Discount Amount	936,132	879,766
Total Carrying Amount	$ 18,899,081	$ 18,248,273
Shares Underlying Principal | shares	3,286,507	3,169,343
Convertible notes payable, Current	$ 6,455,879	$ 6,000,347
Convertible notes payable, Non Current	$ 4,127,015	$ 4,206,873
Minimum [Member]
Conversion price | $ / shares	$ 3.05
Maximum [Member]
Conversion price | $ / shares	$ 3.60
2010 Convertible notes payable [Member]
Interest rate	6.00%	6.00%
Term of Notes	5 years
Conversion price | $ / shares	$ 3.05	$ 3.05
Principal Outstanding	$ 2,000	$ 2,000
Total Carrying Amount	$ 2,000	$ 2,000
Shares Underlying Principal | shares	656	656
2011 Convertible notes payable [Member]
Interest rate	10.00%	10.00%
Term of Notes	5 years
Conversion price | $ / shares	$ 3.05	$ 3.05
Principal Outstanding	$ 500,000	$ 500,000
Total Carrying Amount	$ 500,000	$ 500,000
Shares Underlying Principal | shares	165,173	163,809
2013 Convertible notes payable [Member]
Interest rate	10.00%	10.00%
Term of Notes	2 years
Conversion price | $ / shares	$ 3.60	$ 3.60
Principal Outstanding	$ 200,257	$ 525,257
Total Carrying Amount	$ 200,257	$ 525,257
Shares Underlying Principal | shares	71,446	185,553
2014 Convertible notes payable [Member]
Interest rate	10.00%	10.00%
Term of Notes	Due on demand ~ 2 years
Principal Outstanding	$ 4,403,470	$ 4,378,563
Discount Amount	236,542	353,700
Total Carrying Amount	$ 4,166,928	$ 4,024,863
Shares Underlying Principal | shares	1,151,351	1,120,470
2014 Convertible notes payable [Member] | Minimum [Member]
Conversion price | $ / shares	$ 3.05
2014 Convertible notes payable [Member] | Maximum [Member]
Conversion price | $ / shares	$ 7
2015 Convertible notes payable [Member]
Interest rate	10.00%	10.00%
Term of Notes	Due on demand ~ 2 years
Principal Outstanding	$ 5,384,340	$ 5,681,166
Discount Amount	420,490	526,066
Total Carrying Amount	$ 4,963,850	$ 5,155,100
Shares Underlying Principal | shares	1,462,149	1,517,996
2015 Convertible notes payable [Member] | Minimum [Member]
Conversion price | $ / shares	$ 3.50
2015 Convertible notes payable [Member] | Maximum [Member]
Conversion price | $ / shares	$ 7
2016 Convertible Notes Payable [Member]
Interest rate	10.00%
Term of Notes	Due on demand ~ 2 years
Principal Outstanding	$ 1,028,959
Discount Amount	279,100
Total Carrying Amount	$ 749,859
Shares Underlying Principal | shares	272,872
2016 Convertible Notes Payable [Member] | Minimum [Member]
Conversion price | $ / shares	$ 3.60
2016 Convertible Notes Payable [Member] | Maximum [Member]
Conversion price | $ / shares	$ 4.50
Convertible notes payable [Member]
Principal Outstanding	$ 11,519,026	$ 11,086,986
Discount Amount	936,132	879,766
Total Carrying Amount	$ 10,582,894	$ 10,207,220
Shares Underlying Principal | shares	3,123,647	2,988,484
Principal Outstanding, Current	$ 6,913,862	$ 6,358,698
Principal Outstanding, Non Current	4,605,164	4,728,288
Discount Amount Current	457,983	358,351
Discount Amount Non Current	478,149	521,415
Convertible notes payable, Current	6,455,879	6,000,347
Convertible notes payable, Non Current	$ 4,127,015	$ 4,206,873
Shares Underlying Principal Current | Number	1,915,803	1,762,849
Shares Underlying Principal Non Current | Number	1,207,844	1,225,635
Convertible notes payable [Member] | Minimum [Member]
Conversion price | $ / shares	$ 4.50
Convertible notes payable [Member] | Maximum [Member]
Conversion price | $ / shares	$ 7
2012 Convertible notes payable - related party [Member]
Interest rate	10.00%	10.00%
Term of Notes	Due on demand
Conversion price | $ / shares	$ 3.30	$ 3.30
Principal Outstanding	$ 254,000	$ 298,000
Total Carrying Amount	$ 254,000	$ 298,000
Shares Underlying Principal | shares	88,733	108,505
2015 Convertible notes payable - related party [Member]
Interest rate	10.00%	10.00%
Term of Notes	2 years
Conversion price | $ / shares	$ 4.50	$ 4.50
Principal Outstanding	$ 320,000	$ 320,000
Total Carrying Amount	$ 320,000	$ 320,000
Shares Underlying Principal | shares	74,127	72,354
Convertible notes payable - related party [Member]
Principal Outstanding	$ 574,000	$ 618,000
Total Carrying Amount	$ 254,000	$ 298,000
Shares Underlying Principal | shares	88,733	108,505
Principal Outstanding, Current	$ 254,000	$ 298,000
Principal Outstanding, Non Current	320,000	320,000
Convertible notes payable related parties, Current	254,000	298,000
Convertible notes payable related parties, Non Current	$ 320,000	$ 320,000
Shares Underlying Principal Current | Number	88,733	108,505
Shares Underlying Principal Non Current | Number	74,127	72,354

NOTES PAYABLE (Details 2)

NOTES PAYABLE (Details 2)	Dec. 31, 2015USD ($)
Contractual principal payments due on loans and notes payable for the year ending
2,016	$ 13,973,596
2,017	5,239,167
2,018	622,450
Total	$ 19,835,213

NOTES PAYABLE (Details 3)

NOTES PAYABLE (Details 3) - Warrants [Member] - $ / shares	Sep. 11, 2013	Mar. 31, 2016	Dec. 31, 2015
Stock price	$ 3.60	$ 5	$ 4.70
Term	5 years	2 years 5 months 12 days	2 years 8 months 12 days
Risk-free interest rate	1.72%	0.79%	1.23%
Expected volatility	72.40%	69.20%	64.10%
Convertible notes payable [Member]
Stock price			$ 4.50
Exercise Price			$ 4.90
Term			5 years
Risk-free interest rate			1.57%
Expected volatility			67.30%

STOCKHOLDERS' DEFICIT (Details

STOCKHOLDERS' DEFICIT (Details Narrative) - USD ($)	Jun. 10, 2014	Sep. 11, 2013	Mar. 31, 2016	Mar. 31, 2015	Dec. 31, 2015	Dec. 31, 2014	Sep. 11, 2014
Options granted			300,000
Vesting percentage			33.00%
Exercise price - options			$ 4.70
Share-based compensation			$ 540,516	$ 1,280,790
Warrants outstanding			3,530,918
Private Placement [Member]
Units issued in offering		$ 7,551,253
Units issued in offering (in units)		3,020,501
Unit price of offering		2.50
Warrants issued to broker of the offering		300,000
Exercise price	$ 3.50	$ 3.50
Warrants outstanding							2,225,036
Fair value of outstanding warrants	$ 1,800,000						$ 7,068,000
Number of warrants exercised	1,095,465
Proceeds from exercise of warrants	$ 3,800,000
Issuance of common stock for exercise of warrants	1,095,465
Adjustment ot additional paid-in capital - warrants	$ 1,800,000
Number of registrable securities (shares)							4,115,966
2011 Stock Incentive Option Plan [Member]
Options granted			300,000
Exercise price - options			$ 3.85		$ 3.60	$ 3.68
Total unrecognized compensation cost			$ 900,000
Unrecognized compensation cost weighted average remaining period			2 years 4 months 24 days
Options outstanding			5,020,001		4,753,335	5,669,000
Cashless Exercise Warrants [Member]
Warrants outstanding			3,320,501
Number of shares callable by warrants			996,150
Share price			$ 5
Increase fair value of common stock			$ 1
Cashless Exercise Warrants [Member] | Maximum [Member]
Number of shares callable by warrants			1,383,542
Share price			$ 6
Warrants [Member]
Warrants outstanding		3,320,501	3,320,501		3,320,501
Share price		$ 3.60	$ 5		$ 4.70
Warrants [Member] | Private Placement [Member]
Number of registrable securities (shares)							3,320,501
Replacement Warrants [Member] | Private Placement [Member]
Exercise price	$ 3.50
Warrants outstanding	1,095,465
Fair value of outstanding warrants	$ 2,545,000
Issuance of warrants (in shares)	1,095,465
Warrant exercise inducement expense	$ 3,500,000

STOCKHOLDERS' DEFICIT (Details)

STOCKHOLDERS' DEFICIT (Details) - Warrant [Member]	12 Months Ended
	Dec. 31, 2015shares
Warrants outstanding summary
Warrants outstanding	5,101,450
Granted	110,417
Exercised	(148,256)
Cancelled, forfeited and expired	(1,532,693)
Warrants outstanding	3,530,918

STOCKHOLDERS' DEFICIT (Detail52

STOCKHOLDERS' DEFICIT (Details 1)	3 Months Ended
	Mar. 31, 2016shares
Outstanding
Warrants outstanding	3,530,918
Exercisable	3,530,918
Warrants Issued in 2013 - Exercise Price $3.30 [Member]
Outstanding
Warrants outstanding	50,000
Weighted Average Remaining Contractual Life (Years)	2 years 29 days
Weighted Average Exercise Price	3.30
Exercisable	50,000
Weighted Average Exercise Price	3.30
Warrants Issued in 2013 - Exercise Price $3.50 [Member]
Outstanding
Warrants outstanding	2,225,036
Weighted Average Remaining Contractual Life (Years)	2 years 5 months 12 days
Weighted Average Exercise Price	3.50
Exercisable	2,225,036
Weighted Average Exercise Price	3.50
Warrants Issued in 2013 [Member]
Outstanding
Warrants outstanding	2,275,036
Exercisable	2,275,036
Warrants Issued in 2014 - Exercise Price $3.50 [Member]
Outstanding
Warrants outstanding	1,145,465
Weighted Average Remaining Contractual Life (Years)	2 years 5 months 23 days
Weighted Average Exercise Price	3.50
Exercisable	1,145,465
Weighted Average Exercise Price	3.50
Warrants Issued in 2014 [Member]
Outstanding
Warrants outstanding	1,145,465
Exercisable	1,145,465
Warrants Issued in 2015 - Exercise Price $4.90 [Member]
Outstanding
Warrants outstanding	110,417
Weighted Average Remaining Contractual Life (Years)	3 years 11 months 4 days
Weighted Average Exercise Price	4.90
Exercisable	110,417
Weighted Average Exercise Price	4.90

STOCKHOLDERS' DEFICIT (Detail53

STOCKHOLDERS' DEFICIT (Details 2) - $ / shares	3 Months Ended	12 Months Ended
	Mar. 31, 2016	Dec. 31, 2015
Options, Outstanding [Roll Forward]
Granted or deemed issued	300,000
Weighted Average Exercise Price [Roll Forward]
Options outstanding, end	$ 4.70
2011 Stock Incentive Option Plan [Member]
Options, Outstanding [Roll Forward]
Options outstanding, beginning	4,753,335	5,669,000
Granted or deemed issued	300,000
Exercised		(2,000)
Cancelled, forfeited and expired	(33,334)	(913,665)
Options outstanding, end	5,020,001	4,753,335
Options exercisable	4,628,112	4,379,335
Options available for future grant	3,979,999	4,246,665
Weighted Average Exercise Price [Roll Forward]
Options outstanding, beginning	$ 3.60	$ 3.68
Granted or deemed issued	4.70
Exercised		3.60
Cancelled, forfeited and expired	5.10	4.05
Options outstanding, end	3.85	3.60
Options exercisable	$ 3.59	$ 3.60

COMMITMENTS AND CONTINGENCIES54

COMMITMENTS AND CONTINGENCIES (Details Narrative) - USD ($)	3 Months Ended
	Mar. 31, 2016	Mar. 31, 2015
Commitments and Contingencies Disclosure [Abstract]
Monthly commercialization management fee	$ 5,000
Rent expense	$ 144,364	$ 118,192

COMMITMENTS AND CONTINGENCIES55

COMMITMENTS AND CONTINGENCIES (Details)	Dec. 31, 2015USD ($)
Future minimum lease payments
2,016	$ 415,702
2,017	525,023
2,018	491,240
2,019	123,875
Total	$ 1,555,840

RELATED PARTY TRANSACTIONS (Det

RELATED PARTY TRANSACTIONS (Details Narrative) - Yutaka & Soomi Niihara [Member]	Mar. 18, 2016USD ($)$ / sharesshares
Shares issued to related party | $	$ 99,999
Shares issued to related party (shares) | shares	22,222
Share price | $ / shares	$ 4.50

RELATED PARTY TRANSACTIONS (D57

RELATED PARTY TRANSACTIONS (Details)		3 Months Ended		12 Months Ended
		Mar. 31, 2016USD ($)shares$ / shares		Dec. 31, 2015USD ($)shares$ / shares	Dec. 31, 2015USD ($)$ / shares
Annual Interest Rate		23.00%		23.00%	23.00%
Principal Amount Outstanding		$ 18,899,081		$ 18,248,273	$ 18,248,273
Shares Underlying Principal | shares		3,286,507		3,169,343
Hope Hospice [Member]
Annual Interest Rate		8.00%	[1]	8.00%	8.00%
Date of Loan	[1]	Jan. 17, 2012		Jan. 17, 2012
Term of Loan		Due on demand	[1]	Due on Demand
Principal Amount Outstanding		$ 200,000	[1]	$ 200,000	$ 200,000
Highest Principal Outstanding		200,000	[1]	200,000	$ 200,000
Amount of Interest Paid		$ 8,000	[1]	$ 8,000
Hope Hospice [Member]
Annual Interest Rate		8.00%	[1]	8.00%	8.00%
Date of Loan		Jun. 14, 2012	[1]	Jun. 14, 2012
Term of Loan		Due on demand	[1]	Due on Demand
Principal Amount Outstanding		$ 200,000	[1]	$ 200,000	$ 200,000
Highest Principal Outstanding		200,000	[1]	200,000	$ 200,000
Amount of Interest Paid		$ 4,000	[1]	$ 8,000
Hope Hospice [Member]
Annual Interest Rate		8.00%	[1]	8.00%	8.00%
Date of Loan		Jun. 21, 2012	[1]	Jun. 21, 2012
Term of Loan		Due on demand	[1]	Due on Demand
Principal Amount Outstanding		$ 100,000	[1]	$ 100,000	$ 100,000
Highest Principal Outstanding		100,000	[1]	100,000	$ 100,000
Amount of Interest Paid		$ 2,000	[1]	$ 4,000
Yutaka Niihara [Member]
Annual Interest Rate		10.00%	[2],[3]	10.00%	10.00%
Date of Loan		Dec. 5, 2012	[2],[3]	Dec. 5, 2012
Term of Loan		Due on demand	[2],[3]	Due on Demand
Principal Amount Outstanding		$ 126,730	[2],[3]	$ 126,730	$ 126,730
Highest Principal Outstanding		1,213,700	[2],[3]	1,213,700	$ 1,213,700
Amount of Principal Repaid		$ 1,086,970	[2],[3]	1,086,970
Amount of Interest Paid				$ 56,722
Hope Hospice [Member]
Annual Interest Rate		8.00%	[1]	8.00%	8.00%
Date of Loan		Feb. 11, 2013	[1]	Feb. 11, 2013
Term of Loan		Due on demand	[1]	2 years
Principal Amount Outstanding		$ 50,000	[1],[4]	$ 50,000	$ 50,000
Highest Principal Outstanding		50,000	[1],[4]	50,000	$ 50,000
Amount of Interest Paid		$ 2,000	[1]	$ 2,000
Hope Hospice [Member]
Annual Interest Rate	[1]	10.00%
Date of Loan	[1]	Jan. 7, 2015
Term of Loan	[1]	2 years
Principal Amount Outstanding	[1],[4]	$ 100,000
Highest Principal Outstanding	[1],[4]	$ 100,000
James Lee [Member]
Annual Interest Rate		10.00%	[5]	10.00%	10.00%
Date of Loan		Jan. 26, 2015	[5]	Jan. 26, 2015
Term of Loan		2 years	[5]	2 years
Principal Amount Outstanding		$ 50,000	[4],[5]	$ 50,000	$ 50,000
Highest Principal Outstanding		$ 50,000	[4],[5]	$ 50,000	$ 50,000
Hope Hospice [Member]
Annual Interest Rate		10.00%	[1]	10.00%	10.00%
Date of Loan		Jan. 29, 2015	[1]	Jan. 29, 2015
Term of Loan		2 years	[1]	2 years
Principal Amount Outstanding				$ 30,000	$ 30,000
Highest Principal Outstanding		$ 30,000	[1],[4]	$ 30,000	$ 30,000
Amount of Principal Repaid	[1]	30,000
Amount of Interest Paid	[1]	$ 2,770
Lan T. Tran [Member]
Annual Interest Rate	[3]	10.00%		10.00%	10.00%
Date of Loan	[3]	Feb. 9, 2015		Feb. 9, 2015
Term of Loan	[3]	2 years		2 years
Principal Amount Outstanding	[3],[4]	$ 10,000		$ 10,000	$ 10,000
Highest Principal Outstanding	[3],[4]	$ 10,000		$ 10,000	$ 10,000
Charles Stark [Member]
Annual Interest Rate		10.00%	[3]	10.00%	10.00%
Date of Loan		Feb. 10, 2015	[3]	Feb. 10, 2015
Term of Loan		2 years	[3]	2 years
Principal Amount Outstanding		$ 10,000	[3],[4]	$ 10,000	$ 10,000
Highest Principal Outstanding		$ 10,000	[3],[4]	$ 10,000	$ 10,000
IRA Service Trust Co. FBO Peter B. Ludlum [Member]
Annual Interest Rate		10.00%	[3]	10.00%	10.00%
Date of Loan		Feb. 20, 2015	[3]	Feb. 20, 2015
Term of Loan		2 years	[3]	2 years
Principal Amount Outstanding		$ 10,000	[3],[4]	$ 10,000	$ 10,000
Highest Principal Outstanding		$ 10,000	[3],[4]	$ 10,000	$ 10,000
Cuc T. Tran [Member]
Annual Interest Rate		11.00%	[5]	11.00%	11.00%
Date of Loan		Mar. 5, 2015	[5]	Mar. 5, 2015
Term of Loan		1 years	[5]	1 year
Principal Amount Outstanding		$ 13,161	[5]	$ 13,161	$ 13,161
Highest Principal Outstanding		$ 13,161	[5]	$ 13,161	$ 13,161
Yutaka Niihara [Member]
Annual Interest Rate		10.00%	[2],[3]	10.00%	10.00%
Date of Loan		Apr. 7, 2015	[2],[3]	Apr. 7, 2015
Term of Loan		2 years	[2],[3]	2 years
Principal Amount Outstanding		$ 302,000	[2],[3],[4]	$ 500,000	$ 500,000
Highest Principal Outstanding		500,000	[2],[3],[4]	$ 500,000	$ 500,000
Amount of Principal Repaid	[2],[3]	198,000
Amount of Interest Paid	[2],[3]	$ 15,603
Yutaka Niihara [Member]
Annual Interest Rate		10.00%	[2],[3]	10.00%	10.00%
Date of Loan		May 21, 2015	[2],[3]	May 21, 2015
Term of Loan		Due on demand	[2],[3]	Due on Demand
Principal Amount Outstanding		$ 826,105	[2],[3]	$ 826,105	$ 826,105
Highest Principal Outstanding		826,105	[2],[3]	$ 826,105	$ 826,105
Amount of Interest Paid	[2],[3]	$ 47,822
Masaharu & Emiko Osato [Member]
Annual Interest Rate		11.00%	[2]	11.00%	11.00%
Date of Loan		Dec. 29, 2015	[2]	Dec. 29, 2015
Term of Loan		Due on demand		Due on Demand
Principal Amount Outstanding		$ 300,000	[2]	$ 300,000	$ 300,000
Highest Principal Outstanding		$ 300,000	[2]	300,000	300,000
Lan T. Tran [Member]
Annual Interest Rate	[3]	11.00%
Date of Loan		Feb. 10, 2016
Term of Loan		2 years
Principal Amount Outstanding	[3],[4]	$ 130,510
Highest Principal Outstanding	[3],[4]	$ 130,510
Hideki & Eiko Uehara [Member]
Annual Interest Rate	[5]	11.00%
Date of Loan		Feb. 15, 2016
Term of Loan		Due on demand
Principal Amount Outstanding	[5]	$ 133,333
Highest Principal Outstanding	[5]	$ 133,333
Masaharu & Emiko Osato [Member]
Annual Interest Rate	[2]	11.00%
Date of Loan		Feb. 25, 2016
Term of Loan		Due on demand
Principal Amount Outstanding	[2]	$ 400,000
Highest Principal Outstanding	[2]	400,000
Notes payable - related party [Member]
Principal Amount Outstanding		2,961,838		2,766,304	2,766,304
Highest Principal Outstanding		4,276,809		3,873,275	$ 3,873,275
Amount of Principal Repaid		1,314,970		1,106,970
Amount of Interest Paid		$ 82,195		$ 79,495
Yasushi Nagasaki [Member]
Annual Interest Rate		10.00%	[3]	10.00%	10.00%
Date of Loan		Jun. 29, 2012	[3]	Jun. 29, 2012
Term of Loan		Due on demand	[3]	Due on Demand
Principal Amount Outstanding		$ 254,000	[3]	$ 298,000	$ 298,000
Highest Principal Outstanding		388,800	[3]	388,800	$ 388,800
Amount of Principal Repaid		134,800	[3]	$ 90,800
Amount of Interest Paid	[3]	$ 27,824
Conversion price | $ / shares		$ 3.30		$ 3.30	$ 3.30
Shares Underlying Principal | shares		88,733	[3]	108,505
Convertible notes payable - related party [Member]
Principal Amount Outstanding		$ 254,000		$ 298,000	$ 298,000
Highest Principal Outstanding		388,800		388,800	$ 388,800
Amount of Principal Repaid		134,800		$ 90,800
Amount of Interest Paid		$ 27,824
Shares Underlying Principal | shares		88,733		108,505
Yutaka Niihara [Member]
Annual Interest Rate		10.00%	[2],[3]	10.00%	10.00%
Date of Loan		Sep. 29, 2015		Sep. 29, 2015
Term of Loan		2 years		2 years
Principal Amount Outstanding		$ 100,000	[2],[3]	$ 100,000	$ 100,000
Highest Principal Outstanding		$ 100,000	[2],[3]	$ 100,000	$ 100,000
Conversion price | $ / shares		$ 4.50	[2],[3]	$ 4.50	$ 4.50
Shares Underlying Principal | shares		23,348		22,794
Charles & Kimxa Stark [Member]
Annual Interest Rate		10.00%	[3]	10.00%	10.00%
Date of Loan		Oct. 1, 2015	[3]	Oct. 1, 2015
Term of Loan		2 years	[3]	2 years
Principal Amount Outstanding		$ 20,000	[3]	$ 20,000	$ 20,000
Highest Principal Outstanding		$ 20,000	[3]	$ 20,000	$ 20,000
Conversion price | $ / shares		$ 4.50	[3]	$ 4.50	$ 4.50
Shares Underlying Principal | shares		4,667	[3]	4,556
Yutaka & Soomi Niihara [Member]
Annual Interest Rate		10.00%	[2],[3]	10.00%	10.00%
Date of Loan		Nov. 16, 2015	[2],[3]	Nov. 16, 2015
Term of Loan		2 years	[2],[3]	2 years
Principal Amount Outstanding		$ 200,000	[2],[3]	$ 200,000	$ 200,000
Highest Principal Outstanding		$ 200,000	[2],[3]	$ 200,000	$ 200,000
Conversion price | $ / shares		$ 4.50	[2],[3]	$ 4.50	$ 4.50
Shares Underlying Principal | shares		46,112	[2],[3]	45,004
Long-term convertible notes payable - related party [Member]
Principal Amount Outstanding		$ 320,000		$ 320,000	$ 320,000
Highest Principal Outstanding		$ 320,000		$ 320,000	320,000
Shares Underlying Principal | shares		74,127		72,354
Notes payable and convertible notes payable - related party [Member]
Principal Amount Outstanding		$ 3,535,838		$ 3,384,304	3,384,304
Highest Principal Outstanding		4,985,609		4,582,075	$ 4,582,075
Amount of Principal Repaid		1,449,770		$ 1,197,770
Amount of Interest Paid		$ 110,019
Shares Underlying Principal | shares		162,860		180,859
Lan T. Tran [Member]
Annual Interest Rate	[3]			11.00%	11.00%
Date of Loan	[3]			Feb. 10, 2014
Term of Loan	[3]			2 years
Principal Amount Outstanding	[3],[4]			$ 106,976	$ 106,976
Highest Principal Outstanding	[3],[4]			$ 106,976	$ 106,976
Hideki & Eiko Uehara [Member]
Annual Interest Rate				11.00%	11.00%
Date of Loan					Feb. 15, 2014
Term of Loan					2 years
Principal Amount Outstanding				$ 133,333	$ 133,333
Highest Principal Outstanding				$ 133,333	$ 133,333
Hope Hospice [Member]
Date of Loan				Jan. 7, 2015
Term of Loan				2 years
Yutaka Niihara [Member]
Annual Interest Rate				10.00%	10.00%
Date of Loan				Jan. 29, 2015
Term of Loan				Due on Demand
Highest Principal Outstanding				$ 20,000	$ 20,000
Amount of Principal Repaid				20,000
Amount of Interest Paid				$ 773
[1]	Dr. Niihara, a director and officer of the Company, is also the CEO of Hope Hospice.
[2]	Director
[3]	Officer
[4]	Due on Demand
[5]	Family of Officer/Director

GEOGRAPHIC INFORMATION (Details

GEOGRAPHIC INFORMATION (Details) - USD ($)	3 Months Ended
	Mar. 31, 2016	Mar. 31, 2015
Japan [Member]
Company revenue earned from countries outside of the U.S.
Sales	$ 51,074	$ 42,743
Percentage of revenue (in percent)	64.00%	44.00%
Taiwan [Member]
Company revenue earned from countries outside of the U.S.
Sales	$ 25,211	$ 42,613
Percentage of revenue (in percent)	32.00%	44.00%

SUBSEQUENT EVENTS (Details Narr

SUBSEQUENT EVENTS (Details Narrative) - Subsequent Event [Member] - USD ($)	2 Months Ended
	May. 31, 2016	Dec. 31, 2016	Sep. 30, 2016	Jun. 30, 2016
License Agreement Terms [Member]
Percent of net sales - royalty	4.50%
Percent of net sales - decreased royalty based upon payments	2.50%
License Agreement Terms [Member] | Maximum [Member]
Royalty payment	$ 100,000
Secured Loans [Member]
Number of shares issueable upon warrant exercise	62,500
Number of additional shares issueable due to non-payment		18,750	18,750	37,500
Exercise price	$ 4.50
Number of days loan remains outstanding	30 days
Number of days in period	90 days

SUBSEQUENT EVENTS (Details)

SUBSEQUENT EVENTS (Details) - USD ($)		2 Months Ended
		May. 31, 2016	Mar. 31, 2016	Dec. 31, 2015
Principal Amount Outstanding			$ 18,899,081	$ 18,248,273
Maximum [Member]
Conversion price			$ 3.60
Notes Payable [Member]
Principal Amount Outstanding			$ 4,780,349	$ 4,656,749
Subsequent Event [Member]
Principal Amount Outstanding		$ 1,169,860
Subsequent Event [Member] | Convertible Notes [Member]
Principal Amount Outstanding	[1]	$ 210,160
Interest rate	[1]	10.00%
Term of Notes	[1]	2 years
Conversion price	[1]	$ 4.50
Mandatory conversion - initial public offering price (percent)	[1]	80.00%
Subsequent Event [Member] | Notes Payable [Member]
Principal Amount Outstanding		$ 550,000
Interest rate		11.00%
Subsequent Event [Member] | Notes Payable [Member] | Maximum [Member]
Term of Notes		6 months
Subsequent Event [Member] | Promissory Notes - Related Party [Member]
Principal Amount Outstanding		$ 409,700
Interest rate		10.00%
Term of Notes		2 years
[1]	Includes mandatory conversion at the time of an initial public offering at a conversion price equal to 80% of the initial public offering price.

SUBSEQUENT EVENTS (Details 1)

SUBSEQUENT EVENTS (Details 1) - USD ($)	May. 31, 2016	Mar. 31, 2016
Principal		$ 5,079,981
Subsequent Event [Member] | Secured Loans [Member]
Principal	$ 1,295,000
Interest rate	10.00%