EMI Holding Inactive 10-Q12 May 172017 Q1 Quarterly reportFinancial data

Company Profile

Document and Entity Information

Document and Entity Information - shares	3 Months Ended
Document and Entity Information - shares	Mar. 31, 2017	May 12, 2017
Document And Entity Information
Entity Registrant Name	EMMAUS LIFE SCIENCES, INC.
Entity Central Index Key	1,420,031
Document Type	10-Q
Trading Symbol	EMMA
Document Period End Date	Mar. 31, 2017
Amendment Flag	false
Current Fiscal Year End Date	--12-31
Entity a Well-known Seasoned Issuer	No
Entity a Voluntary Filer	No
Entity's Reporting Status Current	Yes
Entity Filer Category	Smaller Reporting Company
Entity Common Stock, Shares Outstanding		34,742,219
Document Fiscal Period Focus	Q1
Document Fiscal Year Focus	2,017

CONSOLIDATED BALANCE SHEETS (Un

CONSOLIDATED BALANCE SHEETS (Unaudited) - USD ($)	Mar. 31, 2017	Dec. 31, 2016
CURRENT ASSETS
Cash and cash equivalents	$ 3,544,873	$ 1,317,340
Accounts receivable	27,100	14,221
Inventories, net	261,422	166,209
Investment in available-for-sale securities	10,948,608	10,917,301
Marketable securities, pledged to creditor	197,428	179,765
Prepaid expenses and other current assets	101,097	129,204
Total current assets	15,080,528	12,724,040
PROPERTY AND EQUIPMENT, Net	93,008	53,730
OTHER ASSETS
Deposits	212,815	214,808
Total other assets	212,815	214,808
Total Assets	15,386,351	12,992,578
CURRENT LIABILITIES
Accounts payable and accrued expenses	3,886,433	3,201,154
Other current liability	4,019,728
Notes payable, net	4,292,539	4,094,429
Notes payable to related parties, net	1,926,850	1,924,850
Convertible notes payable, net	9,783,487	9,205,007
Convertible notes payable to related parties, net	474,000	474,000
Total current liabilities	24,383,037	18,899,440
LONG-TERM LIABILITIES
Deferred rent	53,075	57,081
Warrant derivative liabilities	11,828,000	10,600,000
Convertible notes payable, net	703,094	997,957
Total long-term liabilities	12,584,169	11,655,038
Total Liabilities	36,967,206	30,554,478
STOCKHOLDERS' DEFICIT
Preferred stock - par value $0.001 per share, 20,000,000 shares authorized, none issued and outstanding
Common stock - par value $0.001 per share, 100,000,000 shares authorized, 34,714,219 and 34,701,219 shares issued and outstanding at March 31, 2017 and December 31, 2016, respectively	34,714	34,701
Additional paid-in capital	95,053,204	92,614,801
Accumulated other comprehensive loss	(3,413,383)	(3,450,746)
Accumulated deficit	(113,255,390)	(106,760,656)
Total stockholders' deficit	(21,580,855)	(17,561,900)
Total Liabilities and Stockholders' Deficit	$ 15,386,351	$ 12,992,578

CONSOLIDATED BALANCE SHEETS (U3

CONSOLIDATED BALANCE SHEETS (Unaudited) (Parenthetical) - $ / shares	Mar. 31, 2017	Dec. 31, 2016
Statement of Financial Position [Abstract]
Preferred stock, par (in dollars per share)	$ 0.001	$ 0.001
Preferred stock, authorized	20,000,000	20,000,000
Common stock, par (in dollars per share)	$ 0.001	$ 0.001
Common stock, authorized	100,000,000	100,000,000
Common stock, issued	34,714,219	34,701,219
Common stock, outstanding	34,714,219	34,701,219

CONSOLIDATED STATEMENTS OF COMP

CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS (Unaudited) - USD ($)	3 Months Ended
	Mar. 31, 2017	Mar. 31, 2016
Income Statement [Abstract]
REVENUES, net	$ 107,477	$ 79,399
COST OF GOODS SOLD	48,260	28,066
GROSS PROFIT	59,217	51,333
OPERATING EXPENSES
Research and development	755,728	502,301
Selling	101,661	93,580
General and administrative	2,799,040	2,292,922
[us-gaap:OperatingExpenses]	3,656,429	2,888,803
LOSS FROM OPERATIONS	(3,597,212)	(2,837,470)
OTHER INCOME (EXPENSE)
Change in fair value of warrant derivative liabilities	(1,228,000)	(863,000)
Interest and other income (loss)	(13,231)	(25,833)
Interest expense	(1,653,891)	(731,202)
[us-gaap:NonoperatingIncomeExpense]	(2,895,122)	(1,620,035)
LOSS BEFORE INCOME TAXES	(6,492,334)	(4,457,505)
INCOME TAXES	2,400	2,400
NET LOSS	(6,494,734)	(4,459,905)
COMPONENTS OF OTHER COMPREHENSIVE INCOME (LOSS)
Unrealized holding gain on securities available-for-sale	48,970	25,905
Unrealized foreign currency translation	(11,607)	11,004
[us-gaap:OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent]	37,363	36,909
COMPREHENSIVE LOSS	$ (6,457,371)	$ (4,422,996)
NET LOSS PER COMMON SHARE (in dollars per share)	$ (0.19)	$ (0.16)
WEIGHTED-AVERAGE COMMON SHARES OUTSTANDING (in shares)	34,706,419	28,465,798

CONSOLIDATED STATEMENT OF CHANG

CONSOLIDATED STATEMENT OF CHANGES IN STOCKHOLDERS' DEFICIT (Unaudited) - 3 months ended Mar. 31, 2017 - USD ($)	Common Stock [Member]	Additional Paid-in Capital [Member]	Accumulated Other Comprehensive Income (Loss) [Member]	Accumulated Deficit [Member]	Total
Balance, beginning at Dec. 31, 2016	$ 34,701	$ 92,614,801	$ (3,450,746)	$ (106,760,656)	$ (17,561,900)
Balance, beginning (in shares) at Dec. 31, 2016	34,701,219
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Stock issued for cash	$ 13	98,787			98,800
Stock issued for cash (in shares)	13,000
Beneficial conversion feature related to convertible and promissory notes payable		1,311,266			1,311,266
Share-based compensation		1,028,350			1,028,350
Unrealized gain on marketable securities, net of tax			48,970		48,970
Foreign currency translation effect			(11,607)		(11,607)
Net loss				(6,494,734)	(6,494,734)
Balance, ending at Mar. 31, 2017	$ 34,714	$ 95,053,204	$ (3,413,383)	$ (113,255,390)	$ (21,580,855)
Balance, ending (in shares) at Mar. 31, 2017	34,714,219

CONSOLIDATED STATEMENTS OF CASH

CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited) - USD ($)	3 Months Ended
CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited) - USD ($)	Mar. 31, 2017	Mar. 31, 2016
CASH FLOWS FROM OPERATING ACTIVITIES
Net loss	$ (6,494,734)	$ (4,459,905)
Adjustments to reconcile net loss to net cash flows used in operating activities
Depreciation and amortization	5,308	3,668
Amortization of discount of convertible notes	1,191,650	238,130
Foreign exchange adjustments on convertible notes and notes payable	103,908	142,760
Share-based compensation	1,028,350	540,516
Change in fair value of warrant derivative liabilities	1,228,000	863,000
Net changes in operating assets and liabilities
Accounts receivable	(12,093)	43,136
Inventories	(91,970)	(78,021)
Prepaid expenses and other current assets	51,633	57,246
Deposits	3,475	16,859
Accounts payable and accrued expenses	937,338	338,171
Other current liability	4,019,339	(65,000)
Deferred rent	(4,016)	(424)
Net cash flows used in operating activities	1,966,188	(2,359,864)
CASH FLOWS USED IN INVESTING ACTIVITIES
Purchases of property and equipment	(40,424)
Net cash flows used in investing activities	(40,424)
CASH FLOWS FROM FINANCING ACTIVITIES
Proceeds from notes payable issued		400,000
Proceeds from convertible notes payable issued	200,000	279,950
Payments of notes payable		(228,000)
Payments of convertible notes		(44,000)
Proceeds from issuance of common stock	98,800	1,799,999
Net cash flows from financing activities	298,800	2,207,949
Effect of exchange rate changes on cash	2,969	3,512
Net increase (decrease) in cash and cash equivalents	2,227,533	(148,403)
Cash and cash equivalents, beginning of period	1,317,340	472,341
Cash and cash equivalents, end of period	3,544,873	323,938
SUPPLEMENTAL DISCLOSURES OF CASH FLOW ACTIVITIES
Interest paid	69,859	146,727
Income taxes paid	$ 2,400	$ 2,400

BASIS OF PRESENTATION

BASIS OF PRESENTATION	3 Months Ended
BASIS OF PRESENTATION	Mar. 31, 2017
Organization, Consolidation and Presentation of Financial Statements [Abstract]
BASIS OF PRESENTATION	NOTE 1 — BASIS OF PRESENTATION The accompanying unaudited consolidated interim financial statements of Emmaus Life Sciences, Inc. and subsidiaries (collectively, the “Company” or “Emmaus”) have been prepared in accordance with accounting principles generally accepted in the United States of America (“GAAP”) on the basis that the Company will continue as a going concern. The consolidated financial statements include the accounts of the Company and its consolidated subsidiaries. All significant intercompany transactions have been eliminated. The Company’s unaudited consolidated interim financial statements contain adjustments, including normal recurring accruals necessary to present fairly the Company’s consolidated financial position, results of operations, comprehensive income (loss) and cash flows. Due to the uncertainty of the Company’s ability to meet its current operating and capital expenses, there is substantial doubt about the Company’s ability to continue as a going concern, as the continuation and expansion of its business is dependent upon obtaining further financing, successful and sufficient market acceptance of its products, and finally, achieving a profitable level of operations. The consolidated interim financial statements do not include any adjustments that might result from the outcome of these uncertainties. The consolidated interim financial statements should be read in conjunction with the Company’s Annual Report on Form 10-K for the year ended December 31, 2016, filed with the Securities and Exchange Commission (“SEC”) on March 31, 2017 (the “Annual Report”). Interim results for the periods presented herein are not necessarily indicative of the results that may be expected for the fiscal year ending December 31, 2017. The preparation of the consolidated financial statements requires the use of management estimates. Actual results could differ materially from those estimates.

SUMMARY OF SIGNIFICANT ACCOUNTI

SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES	3 Months Ended
SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES	Mar. 31, 2017
Accounting Policies [Abstract]
SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES	NOTE 2 — SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES Refer to the Annual Report for a summary of significant accounting policies. There have been no material changes to the Company’s significant accounting policies during the three months ended March 31, 2017. Below are disclosures of certain interim balances, transactions, and significant assumptions used in computing fair value as of and for the three months ended March 31, 2017 and comparative amounts from the prior fiscal periods: Inventories — Inventory by category March 31, 2017 December 31, 2016 Work-in-process $ 139,181 $ 34,462 Finished goods 122,241 131,747 $ 261,422 $ 166,209 Advertising cost — Marketable securities — As of March 31, 2017, 39,250 shares of CellSeed stock were pledged to secure a $300,000 convertible note issued to Mitsubishi UFJ Capital III Limited Partnership that is due on demand and are classified as current assets, as marketable securities, pledged to creditor. Prepaid expenses and other current assets March 31, 2017 December 31, 2016 Prepaid insurance $ 65,016 $ 100,060 Other prepaid expenses and current assets 36,081 29,144 $ 101,097 $ 129,204 Other Current Liabilities Fair value measurements Period ended Warrant Derivative Liabilities—Stock Purchase Warrants March 31, 2017 December 31, 2016 Balance, beginning of period $ 10,600,000 $ 7,863,000 Change in fair value included in consolidated statements of comprehensive loss 1,228,000 2,737,000 Balance, end of period $ 11,828,000 $ 10,600,000 The value of the liability classified warrants, the value of warrant derivative liabilities and the change in fair value of the liability classified warrants and warrant derivative liabilities were determined using a Binomial Monte-Carlo Cliquet (aka “Ratchet”) Option Pricing Model. The model is similar to traditional Black-Scholes-type option pricing models, except that the exercise price resets at certain dates in the future. The values as of March 31, 2017, December 31, 2016 and the initial value as of September 11, 2013 were calculated based on the following assumptions: March 31, 2017 December 31, 2016 Initial Value Stock price $ 6.60 $ 6.00 $ 3.60 Risk-free interest rate 1.14 % 1.09 % 1.72 % Expected volatility (peer group) 64.70 % 68.30 % 72.40 % Expected life (in years) 1.45 1.70 5.00 Number outstanding 3,320,501 3,320,501 3,320,501 Balance, end of period: Liability classified warrants $ — $ — $ 7,541,000 Warrant derivative liabilities $ 11,828,000 $ 10,600,000 $ — Debt and related party debt Type of Loan Term of Loan Stated Annual Interest Rate Original Loan Principal Amount Conversion Rate Beneficial Conversion Discount Amount Warrants Issued with Notes Exercise Price Warrant FMV Discount Amount Effective Interest Rate Including Discounts 2016 convertible notes payable Due on demand - 2 years 10 % 10,866,291 $3.50- $4.50 3,196,544 75,000 $ 4.70 161,658 14% - 102% 2017 convertible notes payable Due on demand - 2 years 10 % 1,834,848 $3.50- $7.60 1,311,266 — $ — — 10% - 99% Total $ 12,701,139 $ 4,507,810 75,000 $ 161,658 Related party notes are disclosed as separate line items in the Company’s balance sheets. Net loss per share Recent accounting pronouncements Presentation of Financial Statements—Going Concern (Subtopic 205-40): Disclosure of Uncertainties about an Entity’s Ability to Continue as a Going Concern. In January 2016, the Financial Accounting Standards Board (“FASB”) issued Accounting Standards Update (“ASU”) No. 2016-01, Recognition and Measurement of Financial Assets and Financial Liabilities In February 2016, the FASB issued ASU No. 2016-02, Leases In March 2016, the FASB issued ASU 2016-09, Compensation—Stock Compensation (Topic 718): Improvements to Employee Share-Based Payment Accounting In April 2016, the FASB issued ASU 2016-10, Revenue from Contracts with Customers (Topic 606): Identifying Performance Obligations and Licensing In August 2016, the FASB issued ASU No. 2016-15, Statement of Cash Flows (Topic 230), Classification of Certain Cash Receipts and Cash Payments In January 2017, the FASB issued ASU No. 2017-01, Business Combinations (Topic 805): Clarifying the Definition of a Business

PROPERTY AND EQUIPMENT

PROPERTY AND EQUIPMENT	3 Months Ended
PROPERTY AND EQUIPMENT	Mar. 31, 2017
Property, Plant and Equipment [Abstract]
PROPERTY AND EQUIPMENT	NOTE 3 — PROPERTY AND EQUIPMENT Property and equipment consisted of the following at: March 31, 2017 December 31, 2016 Equipment $ 180,914 $ 175,410 Leasehold improvements 69,189 30,804 Furniture and fixtures 75,867 74,760 Subtotal 325,970 280,974 Less: accumulated depreciation (232,962 ) (227,244 ) Total $ 93,008 $ 53,730 During the three months ended March 31, 2017 and 2016, depreciation expense was $5,308 and $3,668, respectively.

ACCOUNTS PAYABLE AND ACCRUED EX

ACCOUNTS PAYABLE AND ACCRUED EXPENSES	3 Months Ended
ACCOUNTS PAYABLE AND ACCRUED EXPENSES	Mar. 31, 2017
Payables and Accruals [Abstract]
ACCOUNTS PAYABLE AND ACCRUED EXPENSES	NOTE 4 — ACCOUNTS PAYABLE AND ACCRUED EXPENSES Accounts payable and accrued expenses consisted of the following at: March 31, 2017 December 31, 2016 Accounts payable Clinical and regulatory expenses $ 322,603 $ 145,239 Legal expenses 99,859 43,700 Consulting fees 191,473 99,800 Accounting fees 42,500 65,267 Selling expenses 24,991 60,724 Investor relations and public relations expenses 11,099 19,931 Other vendors 259,620 41,640 Total accounts payable 952,145 476,301 Accrued interest payable, related parties 262,766 274,851 Accrued interest payable 1,562,739 1,441,450 Accrued expenses 817,117 716,886 Deferred salary 291,666 291,666 Total accounts payable and accrued expenses $ 3,886,433 $ 3,201,154

NOTES PAYABLE

NOTES PAYABLE	3 Months Ended
NOTES PAYABLE	Mar. 31, 2017
Debt Disclosure [Abstract]
NOTES PAYABLE	NOTE 5 — NOTES PAYABLE Notes payable consisted of the following at March 31, 2017 and December 31, 2016: Year Issued Interest Rate Range Term of Notes Conversion Price Principal Outstanding March 31, 2017 Discount Amount March 31, 2017 Carrying Amount March 31, 2017 Shares Underlying Notes March 31, 2017 Principal Outstanding December 31, 2016 Discount Amount December 31, 2016 Carrying Amount December 31, 2016 Shares Underlying Notes December 31, 2016 Notes payable 2013 10% Due on demand — $ 897,400 $ — $ 897,400 — $ 854,900 $ — $ 854,900 — 2015 11% Due on demand — 1,948,700 — 1,948,700 — 2,406,194 — 2,406,194 — 2016 11% Due on demand — 833,335 — 833,335 — 833,335 — 833,335 — 2017 11% Due on demand — 613,104 — 613,104 — — — — — $ 4,292,539 $ — $ 4,292,539 — $ 4,094,429 $ — $ 4,094,429 — Current $ 4,292,539 $ — $ 4,292,539 — $ 4,094,429 $ — $ 4,094,429 — Non-current $ — $ — $ — — $ — $ — $ — — Notes payable - related party 2012 8% Due on demand — $ 500,000 $ — $ 500,000 — $ 500,000 $ — $ 500,000 — 2013 8% Due on demand — 50,000 — 50,000 — 50,000 — 50,000 — 2015 10% - 11% Due on demand — 504,340 — 504,340 — 514,340 — 514,340 — 2016 10% - 11% Due on demand — 860,510 — 860,510 — 860,510 — 860,510 — 2017 10% Due on demand — 12,000 — 12,000 — — — — — $ 1,926,850 $ — $ 1,926,850 — $ 1,924,850 $ — $ 1,924,850 — Current $ 1,926,850 $ — $ 1,926,850 — $ 1,924,850 $ — $ 1,924,850 — Non-current $ — $ — $ — — $ — $ — $ — — Convertible notes payable 2011 10% 5 years $3.05 $ 300,000 $ — $ 300,000 98,285 $ 300,000 $ — $ 300,000 98,285 2014 10% Due on demand - 2 years $3.05-$3.60 472,636 — 472,636 160,782 452,168 — 452,168 152,986 2015 10% 2 years $3.50-$3.60 2,279,226 28,731 2,250,495 693,814 2,904,800 104,389 2,800,411 889,115 2016 10% Due on demand — 1 year $3.50-$4.50 7,299,620 478,884 6,820,736 1,994,045 8,126,129 1,475,744 6,650,385 2,193,687 2017 10% Due on demand — 1 year $3.50-$7.60 1,834,848 1,192,134 642,714 493,089 — — — — $ 12,186,330 $ 1,699,749 $ 10,486,581 3,440,015 $ 11,783,097 $ 1,580,133 $ 10,202,964 3,334,073 Current $ 11,325,037 $ 1,541,550 $ 9,783,487 3,211,532 $ 10,499,303 $ 1,294,296 $ 9,205,007 2,984,161 Non-current $ 861,293 $ 158,199 $ 703,094 228,483 $ 1,283,794 $ 285,837 $ 997,957 349,912 Convertible notes payable - related party 2012 10% Due on demand $3.30 $ 254,000 $ — $ 254,000 78,888 $ 254,000 $ — $ 254,000 94,532 2015 10% 2 years $4.50 220,000 — 220,000 55,668 220,000 — 220,000 54,463 $ 474,000 $ — $ 474,000 134,556 $ 474,000 $ — $ 474,000 148,995 Current $ 474,000 $ — $ 474,000 134,556 $ 474,000 $ — $ 474,000 148,995 Non-current $ — $ — $ — — $ — $ — $ — — Grand Total $ 18,879,719 $ 1,699,749 $ 17,179,970 3,574,571 $ 18,276,376 $ 1,580,133 $ 16,696,243 3,483,068 The weighted average stated interest rate of notes payable as of March 31, 2017 and December 31, 2016 was 10%. The weighted average effective interest rate of notes payable for the three-month period ended March 31, 2017 and the year ended December 31, 2016 was 28% and 27% respectively, after giving effect to discounts relating to beneficial conversion features and the fair value of warrants issued in connection with these notes. The notes payable and convertible notes payable do not have restrictive financial covenants or acceleration clauses associated with a material adverse change event. The holders of the convertible notes have the option to convert their notes into Company common stock at the stated conversion price during the term of their convertible notes. Conversion prices on these convertible notes payable range from $3.05 to $3.60 per share. Certain notes with a $4.50 or a $7.00 stated conversion price in the second year of their two-year term are subject to automatic conversion into shares of Company common stock at a conversion price equal to 80% of the initial public offering price at the time of a qualified public offering. All notes due on demand are treated as current liabilities. Contractual principal payments due on notes payable are as follows: Year Ending March 31, 2017 2017 $ 17,473,957 2018 1,405,762 Total $ 18,879,719 The Company estimated the total fair value of any beneficial conversion feature and accompanying warrants in allocating the note proceeds. The proceeds allocated to the beneficial conversion feature were determined by taking the estimated fair value of shares issuable under the convertible notes less the fair value of the number of shares that would be issued if the conversion rate equaled the fair value of Company common stock as of the date of issuance (see Note 2). The fair value of the warrants issued in conjunction with notes was determined using the Black Scholes Merton Option Pricing Model with the following inputs for the periods ended December 31, 2016. The Company did not issue any warrants in conjunction with notes in the three months ended March 31, 2017. December 31, 2016 Stock price $ 5.00 Exercise price $ 4.50 - 4.70 Term 5 years Risk-free interest rate 1.01 - 1.28 % Expected dividend yield — Expected volatility 65.4 - 69.6 % In situations where the notes included both a beneficial conversion feature and a warrant, the proceeds were allocated to the warrants and beneficial conversion feature based on their respective pro rata fair values.

STOCKHOLDERS' DEFICIT

STOCKHOLDERS' DEFICIT	3 Months Ended
STOCKHOLDERS' DEFICIT	Mar. 31, 2017
Stockholders' Equity Note [Abstract]
STOCKHOLDERS' DEFICIT	NOTE 6 — STOCKHOLDERS’ DEFICIT Private placement — The warrants issued in the Private Placement and the Broker Warrants entitle the holders thereof to purchase, at any time on or prior to September 11, 2018, shares of common stock of the Company at an exercise price of $3.50 per share. The warrants contain non-standard anti-dilution protection and, consequently, are being accounted for as liabilities, were originally recorded at fair value, and are adjusted to fair market value each reporting period. Because the shares of common stock underlying the Private Placement warrants and Broker Warrants were not effectively registered for resale by September 11, 2014, the warrant holders have an option to exercise the warrants using a cashless exercise feature. The shares have not been registered for resale as of March 31, 2017. The availability to warrant holders of the cashless exercise feature as of September 11, 2014 caused the then-outstanding 2,225,036 Private Placement warrants and Broker Warrants with fair value of $7,068,000 to be reclassified from liability classified warrants to warrant derivative liabilities and to continue to be remeasured at fair value each reporting period. On June 10, 2014, certain warrant holders exercised 1,095,465 warrants issued in the Private Placement for the exercise price of $3.50 per share, resulting in the Company receiving aggregate exercise proceeds of $3.8 million and issuing 1,095,465 shares of common stock. Prior to exercise, these Private Placement warrants were accounted for at fair value as liability classified warrants. As of June 10, 2014, immediately prior to exercise, the carrying value of these Private Placement warrants was reduced to their fair value immediately prior to exercise of $1.8 million, representing their intrinsic value, with this adjusted carrying value of $1.8 million being transferred to additional paid-in capital. Also on June 10, 2014, based on an offer made to holders of Private Placement warrants in connection with such exercises, the Company issued an aggregate of 1,095,465 replacement warrants to holders exercising Private Placement warrants, which replacement warrants have terms that are generally the same as the exercised warrants, including an expiration date of September 11, 2018 and an exercise price of $3.50 per share. The replacement warrants are treated for accounting purposes as liability classified warrants, and their issuance gave rise to a $3.5 million warrant exercise inducement expense based on their fair value as of issuance as determined using a Binomial Monte-Carlo Cliquet (aka Ratchet) Option Pricing Model. Because the shares of common stock underlying the replacement warrants were not effectively registered for resale by June 10, 2015, the warrant holders have an option to exercise the warrants using a cashless exercise feature. The shares have not been registered for resale as of March 31, 2017. The availability to warrant holders of the cashless exercise feature as of June 10, 2015 caused the then-outstanding 1,095,465 replacement warrants with fair value of $2,545,000 to be reclassified from liability classified warrants to warrant derivative liabilities and to continue to be remeasured at fair value each reporting period. As of March 31, 2017, the aggregate fair value of the Private Placement warrants, replacement warrants and the Broker Warrants was $11,828,000 (see Note 2). For further details regarding registration rights associated with the Private Placement warrants, replacement warrants and Broker Warrants, see the Registration Rights section below in this footnote. A summary of outstanding warrants as of March 31, 2017 and December 31, 2016 is presented below: Three months ended March 31, 2017 Year ended December 31, 2016 Warrants outstanding, beginning of period 5,024,668 3,530,918 Granted — 1,493,750 Exercised — — Cancelled, forfeited or expired — — Warrants outstanding, end of period 5,024,668 5,024,668 A summary of outstanding warrants by year issued and exercise price as of March 31, 2017 is presented below: Outstanding Exercisable Exercise Price Number of Warrants Issued Weighted Average Remaining Contractual Life (Years) Weighted Average Exercise Price Total Weighted Average Exercise Price At December 31, 2013 $ 3.30 50,000 1.08 $ 3.30 50,000 $ 3.30 $ 3.50 2,225,036 1.45 $ 3.50 2,225,036 $ 3.50 2013 total 2,275,036 2,275,036 At December 31, 2014 $ 3.50 1,145,465 1.48 $ 3.50 1,145,465 $ 3.50 2014 total 1,145,465 1,145,465 At December 31, 2015 $ 4.90 110,417 2.93 $ 4.90 110,417 $ 4.90 2015 total 110,417 110,417 At December 31, 2016 $ 4.50 118,750 4.25 $ 4.50 118,750 $ 4.50 $ 4.70 75,000 4.09 $ 4.70 75,000 $ 4.70 $ 5.00 1,300,000 4.11 $ 5.00 1,300,000 $ 5.00 2016 Total 1,493,750 1,493,750 Total 5,024,668 5,024,668 Stock options Summaries of outstanding options as of March 31, 2017 and December 31, 2016 are presented below. March 31, 2017 December 31, 2016 Number of Options Weighted- Average Exercise Price Number of Options Weighted- Average Exercise Price Options outstanding, beginning of period 6,955,200 $ 4.10 4,753,335 $ 3.60 Granted or deemed issued — $ — 2,596,200 $ 4.97 Exercised — $ — (15,866 ) $ 3.60 Cancelled, forfeited and expired — $ — (378,469 ) $ 3.91 Options outstanding, end of period 6,955,200 $ 4.10 6,955,200 $ 4.10 Options exercisable, end of period 4,503,000 $ 3.62 4,372,667 $ 3.59 Options available for future grant, end of period 2,044,800 2,044,800 During the three months ended March 31, 2017 and 2016, the Company recognized $1.0 million and $0.5 million, respectively, of share-based compensation expense arising from stock options. As of March 31, 2017, there was $7.0 million of total unrecognized compensation expense related to unvested share-based compensation arrangements granted under the Company’s 2011 Stock Incentive Plan. That expense is expected to be recognized over the weighted-average remaining period of 1.9 years. Registration rights — The Company has not yet filed a registration statement with respect to the resale of the Registrable Securities. The Company believes that it has used commercially reasonable efforts to file a registration statement with respect to the resale of Registrable Securities. Korean Private Placement On September 29, 2016, KPM and Hanil purchased and acquired from the Company 3,777,778 shares and 666,667 shares, respectively, of common stock at a price of $4.50 a share for $17 million and $3 million, respectively, for a gross total of $20 million. The Company recognized $720,000 as a reduction to its additional paid-in-capital for fees and commissions payable by the Company in connection with the transaction. Pursuant to the terms of the Letter of Agreement dated September 12, 2016, the Company invested $13 million and $1 million in capital increases by KPM and Hanil, respectively, at $15.32 and $3.68, respectively, per capita share. Pursuant to the terms of a subscription agreement dated as of September 11, 2013 among the Company and certain purchasers of shares of our common stock and warrants to purchase shares of our common stock, the purchasers are entitled to participation rights with respect to the sale of shares pursuant to the Letter of Agreement. To the extent the purchasers exercise their participation rights, we may be obliged to sell to them a specified number of shares of our common stock at the price per share and other terms set forth in the Letter of Agreement. There can be no assurance that any purchaser will exercise its participation rights or that any shares of our common stock will be issued to any purchaser.

COMMITMENTS AND CONTINGENCIES

COMMITMENTS AND CONTINGENCIES	3 Months Ended
COMMITMENTS AND CONTINGENCIES	Mar. 31, 2017
Commitments and Contingencies Disclosure [Abstract]
COMMITMENTS AND CONTINGENCIES	NOTE 7 — COMMITMENTS AND CONTINGENCIES Distribution contract — Operating leases Future minimum lease payments under the agreements are as follows as of March 31, 2017: Year Amount 2017 (nine months) $ 413,194 2018 537,279 2019 126,115 $ 1,076,588

RELATED PARTY TRANSACTIONS

RELATED PARTY TRANSACTIONS	3 Months Ended
RELATED PARTY TRANSACTIONS	Mar. 31, 2017
Related Party Transactions [Abstract]
RELATED PARTY TRANSACTIONS	NOTE 8 — RELATED PARTY TRANSACTIONS The following table sets forth information relating to the Company’s loans from related parties outstanding as of March 31, 2017. Class Lender Annual Interest Rate Date of Loan Term of Loan Principal Amount Outstanding at March 31, 2017 Highest Principal Outstanding Amount of Principal Repaid or Converted into Stock Amount of Interest Paid Conversion Rate Shares Underlying Notes at March 31, 2017 Notes payable to related parties—current: Hope Hospice(1) 8 % 1/17/2012 Due on demand $ 200,000 $ 200,000 $ — $ 4,000 $ — — Hope Hospice(1) 8 % 6/14/2012 Due on demand 200,000 200,000 — — — — Hope Hospice(1) 8 % 6/21/2012 Due on demand 100,000 100,000 — — — — Hope Hospice(1) 8 % 2/11/2013 Due on demand 50,000 50,000 — — — — Hope Hospice(1) 10 % 1/7/2015 Due on demand 100,000 100,000 — — — — IRA Service Trust Co. FBO Peter B. Ludlum(2) 10 % 2/20/2015 Due on demand 10,000 10,000 — — — — Yutaka Niihara(2)(3) 10 % 5/21/2015 Due on demand 94,340 826,105 731,765 — — — Masaharu & Emiko Osato(3) 11 % 12/29/2015 Due on demand 300,000 300,000 — — — — Lan T. Tran(2) 11 % 2/10/2016 Due on demand 130,510 130,510 — — — — Masaharu & Emiko Osato(3) 11 % 2/25/2016 Due on demand 400,000 400,000 — — — — Hope Hospice(1) 10 % 4/4/2016 Due on demand 50,000 50,000 — — — — Lan T. Tran(2) 10 % 4/29/2016 Due on demand 20,000 20,000 — — — — IRA Service Trust Co. FBO Peter B. Ludlum(2) 10 % 5/5/2016 Due on demand 10,000 10,000 — — — — Hope Hospice(1) 10 % 6/3/2016 Due on demand 250,000 250,000 — — — — Lan T. Tran(2) 10 % 2/9/2017 Due on demand 12,000 12,000 — — — — Sub total $ 1,926,850 $ 2,658,615 $ 731,765 $ 4,000 $ — — Convertible notes payable to related parties—current: Yasushi Nagasaki(2) 10 % 6/29/2012 Due on demand $ 254,000 $ 388,800 $ 134,800 $ 57,886 $ 3.30 78,888 Charles & Kimxa Stark(2) 10 % 10/1/2015 2 years 20,000 20,000 — — 4.50 5,111 Yutaka & Soomi Niihara(2)(3) 10 % 11/16/2015 2 years 200,000 200,000 — — 4.50 50,557 Sub total $ 474,000 $ 608,800 $ 134,800 $ 57,886 — 134,556 Total $ 2,400,850 $ 3,267,415 $ 866,565 $ 61,886 — 134,556 (1) Dr. Niihara, a director and officer of the Company, is also the Chief Executive Officer of Hope Hospice. (2) Officer. (3) Director. (4) Family of Officer/Director. The following table sets forth information relating to the Company’s loans from related persons outstanding as of December 31, 2016. Class Lender Annual Interest Rate Date of Loan Term of Loan Principal Amount Outstanding at December 31, 2016 Highest Principal Outstanding Amount of Principal Repaid or Converted into Stock Amount of Interest Paid Conversion Rate Shares Underlying Notes at December 31, 2016 Notes payable to related parties—current: Hope Hospice(1) 8 % 1/17/2012 Due on demand $ 200,000 $ 200,000 $ — $ 20,000 $ — — Hope Hospice(1) 8 % 6/14/2012 Due on demand 200,000 200,000 — 20,000 — — Hope Hospice(1) 8 % 6/21/2012 Due on demand 100,000 100,000 — 10,000 — — Hope Hospice(1) 8 % 2/11/2013 Due on demand 50,000 50,000 — 5,000 — — Hope Hospice(1) 10 % 1/7/2015 Due on demand 100,000 100,000 — — — — Lan T. Tran(2) 10 % 2/9/2015 Due on demand 10,000 10,000 — — — — IRA Service Trust Co. FBO Peter B. Ludlum(2) 10 % 2/20/2015 Due on demand 10,000 10,000 — — — — Yutaka Niihara(2)(3) 10 % 5/21/2015 Due on demand 94,340 826,105 731,765 47,822 — — Masaharu & Emiko Osato(3) 11 % 12/29/2015 Due on demand 300,000 300,000 — — — — Lan T. Tran(2) 11 % 2/10/2016 Due on demand 130,510 130,510 — — — — Hideki & Eiko Uehara(4) 11 % 2/15/2016 Due on demand — 133,333 133,333 12,226 — — Masaharu & Emiko Osato(3) 11 % 2/25/2016 Due on demand 400,000 400,000 — — — — Hope Hospice(1) 10 % 4/4/2016 Due on demand 50,000 50,000 — — — — Willis C. Lee(2)(3) 10 % 4/8/2016 Due on demand — 79,700 79,700 1,288 — — Lan T. Tran(2) 10 % 4/29/2016 Due on demand 20,000 20,000 — — — — IRA Service Trust Co. FBO Peter B. Ludlum(2) 10 % 5/5/2016 Due on demand 10,000 10,000 — — — — Hope Hospice(1) 10 % 6/3/2016 Due on demand 250,000 250,000 — — — — Sub total $ 1,924,850 $ 2,869,648 $ 944,798 $ 116,336 $ — — Convertible notes payable to related parties—current: Yasushi Nagasaki(2) 10 % 6/29/2012 Due on demand $ 254,000 $ 388,800 $ 134,800 $ 27,824 $ 3.30 94,532 Charles & Kimxa Stark(2) 10 % 10/1/2015 2 years 20,000 20,000 — — 4.50 5,002 Yutaka & Soomi Niihara(2)(3) 10 % 11/16/2015 2 years 200,000 200,000 — — 4.50 49,461 Sub total $ 474,000 $ 608,800 $ 134,800 $ 27,824 — 148,995 Total $ 2,398,850 $ 3,478,448 $ 1,079,598 $ 144,160 — 148,995 (1) Dr. Niihara, who is the Company’s CEO, is also the CEO of Hope Hospice. (2) Officer (3) Director (4) Family of Officer/Director

GEOGRAPHIC INFORMATION

GEOGRAPHIC INFORMATION	3 Months Ended
GEOGRAPHIC INFORMATION	Mar. 31, 2017
Segment Reporting [Abstract]
GEOGRAPHIC INFORMATION	NOTE 9 — GEOGRAPHIC INFORMATION For the three months ended March 31, 2017 and 2016, the Company earned revenue from countries outside of the United States as outlined in the table below: Country Revenues for the three months ended March 31, 2017 % of total revenue for the three months ended March 31, 2017 Revenues for the three months ended March 31, 2016 % of total revenue for the three months ended March 31, 2016 Japan $ 28,558 27 % $ 51,074 64 % Taiwan 64,300 60 % 25,211 32 % The Company did not have any significant currency translation or foreign transaction adjustments during the three months ended March 31, 2017 or 2016.

SUBSEQUENT EVENTS

SUBSEQUENT EVENTS	3 Months Ended
SUBSEQUENT EVENTS	Mar. 31, 2017
Subsequent Events [Abstract]
SUBSEQUENT EVENTS	NOTE 10 — SUBSEQUENT EVENTS Subsequent to March 31, 2017, the Company issued the following: Note issued after March 31, 2017 Amount Annual Interest Rate Term of Note Conversion Price Convertible notes $ 4,085,587 10.00 % Due on demand ~ 2 Years $ 3.50 Convertible notes $ 555,591 10.00 % 2 years $ 3.60 Promissory note $ 1,500,000 11.00 % Due on demand ~ 2 Years — Total $ 6,141,178 Subsequent to March 31, 2017, the Company issued the following: Common Shares Issued after March 31, 2017 Amount Number of Shares Issued Common shares $ 212,800 28,000 Total $ 212,800 28,000 Subsequent to March 31, 2017, the Company announced that the Oncologic Drug Advisory Committee of the U.S. Food and Drug Administration (FDA) has set a date of May 24, 2017 to review the Company’s New Drug Application (NDA) for its orally-administered pharmaceutical grade L-glutamine product (Endari™), for the treatment of sickle cell disease.

SUMMARY OF SIGNIFICANT ACCOUN17

SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Policies)	3 Months Ended
SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Policies)	Mar. 31, 2017
Accounting Policies [Abstract]
Inventories	Inventories — Inventory by category March 31, 2017 December 31, 2016 Work-in-process $ 139,181 $ 34,462 Finished goods 122,241 131,747 $ 261,422 $ 166,209
Advertising cost	Advertising cost —
Marketable securities	Marketable securities — As of March 31, 2017, 39,250 shares of CellSeed stock were pledged to secure a $300,000 convertible note issued to Mitsubishi UFJ Capital III Limited Partnership that is due on demand and are classified as current assets, as marketable securities, pledged to creditor.
Prepaid expenses and other current assets	Prepaid expenses and other current assets March 31, 2017 December 31, 2016 Prepaid insurance $ 65,016 $ 100,060 Other prepaid expenses and current assets 36,081 29,144 $ 101,097 $ 129,204
Other Current Liabilities	Other Current Liabilities
Fair value measurements	Fair value measurements Period ended Warrant Derivative Liabilities—Stock Purchase Warrants March 31, 2017 December 31, 2016 Balance, beginning of period $ 10,600,000 $ 7,863,000 Change in fair value included in consolidated statements of comprehensive loss 1,228,000 2,737,000 Balance, end of period $ 11,828,000 $ 10,600,000 The value of the liability classified warrants, the value of warrant derivative liabilities and the change in fair value of the liability classified warrants and warrant derivative liabilities were determined using a Binomial Monte-Carlo Cliquet (aka “Ratchet”) Option Pricing Model. The model is similar to traditional Black-Scholes-type option pricing models, except that the exercise price resets at certain dates in the future. The values as of March 31, 2017, December 31, 2016 and the initial value as of September 11, 2013 were calculated based on the following assumptions: March 31, 2017 December 31, 2016 Initial Value Stock price $ 6.60 $ 6.00 $ 3.60 Risk-free interest rate 1.14 % 1.09 % 1.72 % Expected volatility (peer group) 64.70 % 68.30 % 72.40 % Expected life (in years) 1.45 1.70 5.00 Number outstanding 3,320,501 3,320,501 3,320,501 Balance, end of period: Liability classified warrants $ — $ — $ 7,541,000 Warrant derivative liabilities $ 11,828,000 $ 10,600,000 $ —
Debt and related party debt	Debt and related party debt Type of Loan Term of Loan Stated Annual Interest Rate Original Loan Principal Amount Conversion Rate Beneficial Conversion Discount Amount Warrants Issued with Notes Exercise Price Warrant FMV Discount Amount Effective Interest Rate Including Discounts 2016 convertible notes payable Due on demand - 2 years 10 % 10,866,291 $3.50- $4.50 3,196,544 75,000 $ 4.70 161,658 14% - 102% 2017 convertible notes payable Due on demand - 2 years 10 % 1,834,848 $3.50- $7.60 1,311,266 — $ — — 10% - 99% Total $ 12,701,139 $ 4,507,810 75,000 $ 161,658 Related party notes are disclosed as separate line items in the Company’s balance sheets.
Net loss per share	Net loss per share
Recent accounting pronouncements	Recent accounting pronouncements Presentation of Financial Statements—Going Concern (Subtopic 205-40): Disclosure of Uncertainties about an Entity’s Ability to Continue as a Going Concern. In January 2016, the Financial Accounting Standards Board (“FASB”) issued Accounting Standards Update (“ASU”) No. 2016-01, Recognition and Measurement of Financial Assets and Financial Liabilities In February 2016, the FASB issued ASU No. 2016-02, Leases In March 2016, the FASB issued ASU 2016-09, Compensation—Stock Compensation (Topic 718): Improvements to Employee Share-Based Payment Accounting In April 2016, the FASB issued ASU 2016-10, Revenue from Contracts with Customers (Topic 606): Identifying Performance Obligations and Licensing In August 2016, the FASB issued ASU No. 2016-15, Statement of Cash Flows (Topic 230), Classification of Certain Cash Receipts and Cash Payments In January 2017, the FASB issued ASU No. 2017-01, Business Combinations (Topic 805): Clarifying the Definition of a Business

SUMMARY OF SIGNIFICANT ACCOUN18

SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Tables)	3 Months Ended
SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Tables)	Mar. 31, 2017
Accounting Policies [Abstract]
Schedule of inventory	The below table presents inventory by category: Inventory by category March 31, 2017 December 31, 2016 Work-in-process $ 139,181 $ 34,462 Finished goods 122,241 131,747 $ 261,422 $ 166,209
Schedule of prepaid expenses and other current assets	Prepaid expenses and other current assets consisted of the following at March 31, 2017 and December 31, 2016: March 31, 2017 December 31, 2016 Prepaid insurance $ 65,016 $ 100,060 Other prepaid expenses and current assets 36,081 29,144 $ 101,097 $ 129,204
Schedule of changes in fair value of Level 3 liabilities	The following table presents the activity for those items measured at fair value on a recurring basis using Level 3 inputs during the three months ended March 31, 2017 and the year ended December 31, 2016: Period ended Warrant Derivative Liabilities—Stock Purchase Warrants March 31, 2017 December 31, 2016 Balance, beginning of period $ 10,600,000 $ 7,863,000 Change in fair value included in consolidated statements of comprehensive loss 1,228,000 2,737,000 Balance, end of period $ 11,828,000 $ 10,600,000
Schedule of assumptions used in the valuation of warrants	The values as of March 31, 2017, December 31, 2016 and the initial value as of September 11, 2013 were calculated based on the following assumptions: March 31, 2017 December 31, 2016 Initial Value Stock price $ 6.60 $ 6.00 $ 3.60 Risk-free interest rate 1.14 % 1.09 % 1.72 % Expected volatility (peer group) 64.70 % 68.30 % 72.40 % Expected life (in years) 1.45 1.70 5.00 Number outstanding 3,320,501 3,320,501 3,320,501 Balance, end of period: Liability classified warrants $ — $ — $ 7,541,000 Warrant derivative liabilities $ 11,828,000 $ 10,600,000 $ —
Schedule of notes payable with beneficial conversion feature or warrants	The following table presents the effective interest rates on loans originated and refinanced in the respective periods that either had a beneficial conversion feature or an attached warrant: Type of Loan Term of Loan Stated Annual Interest Rate Original Loan Principal Amount Conversion Rate Beneficial Conversion Discount Amount Warrants Issued with Notes Exercise Price Warrant FMV Discount Amount Effective Interest Rate Including Discounts 2016 convertible notes payable Due on demand - 2 years 10 % 10,866,291 $3.50- $4.50 3,196,544 75,000 $ 4.70 161,658 14% - 102% 2017 convertible notes payable Due on demand - 2 years 10 % 1,834,848 $3.50- $7.60 1,311,266 — $ — — 10% - 99% Total $ 12,701,139 $ 4,507,810 75,000 $ 161,658

PROPERTY AND EQUIPMENT (Tables)

PROPERTY AND EQUIPMENT (Tables)	3 Months Ended
PROPERTY AND EQUIPMENT (Tables)	Mar. 31, 2017
Property, Plant and Equipment [Abstract]
Schedule of property and equipment	Property and equipment consisted of the following at: March 31, 2017 December 31, 2016 Equipment $ 180,914 $ 175,410 Leasehold improvements 69,189 30,804 Furniture and fixtures 75,867 74,760 Subtotal 325,970 280,974 Less: accumulated depreciation (232,962 ) (227,244 ) Total $ 93,008 $ 53,730

ACCOUNTS PAYABLE AND ACCRUED 20

ACCOUNTS PAYABLE AND ACCRUED EXPENSES (Tables)	3 Months Ended
ACCOUNTS PAYABLE AND ACCRUED EXPENSES (Tables)	Mar. 31, 2017
Payables and Accruals [Abstract]
Schedule of accounts payable and accrued expenses	Accounts payable and accrued expenses consisted of the following at: March 31, 2017 December 31, 2016 Accounts payable Clinical and regulatory expenses $ 322,603 $ 145,239 Legal expenses 99,859 43,700 Consulting fees 191,473 99,800 Accounting fees 42,500 65,267 Selling expenses 24,991 60,724 Investor relations and public relations expenses 11,099 19,931 Other vendors 259,620 41,640 Total accounts payable 952,145 476,301 Accrued interest payable, related parties 262,766 274,851 Accrued interest payable 1,562,739 1,441,450 Accrued expenses 817,117 716,886 Deferred salary 291,666 291,666 Total accounts payable and accrued expenses $ 3,886,433 $ 3,201,154

NOTES PAYABLE (Tables)

NOTES PAYABLE (Tables)	3 Months Ended
NOTES PAYABLE (Tables)	Mar. 31, 2017
Debt Disclosure [Abstract]
Schedule of notes payable	Notes payable consisted of the following at March 31, 2017 and December 31, 2016: Year Issued Interest Rate Range Term of Notes Conversion Price Principal Outstanding March 31, 2017 Discount Amount March 31, 2017 Carrying Amount March 31, 2017 Shares Underlying Notes March 31, 2017 Principal Outstanding December 31, 2016 Discount Amount December 31, 2016 Carrying Amount December 31, 2016 Shares Underlying Notes December 31, 2016 Notes payable 2013 10% Due on demand — $ 897,400 $ — $ 897,400 — $ 854,900 $ — $ 854,900 — 2015 11% Due on demand — 1,948,700 — 1,948,700 — 2,406,194 — 2,406,194 — 2016 11% Due on demand — 833,335 — 833,335 — 833,335 — 833,335 — 2017 11% Due on demand — 613,104 — 613,104 — — — — — $ 4,292,539 $ — $ 4,292,539 — $ 4,094,429 $ — $ 4,094,429 — Current $ 4,292,539 $ — $ 4,292,539 — $ 4,094,429 $ — $ 4,094,429 — Non-current $ — $ — $ — — $ — $ — $ — — Notes payable - related party 2012 8% Due on demand — $ 500,000 $ — $ 500,000 — $ 500,000 $ — $ 500,000 — 2013 8% Due on demand — 50,000 — 50,000 — 50,000 — 50,000 — 2015 10% - 11% Due on demand — 504,340 — 504,340 — 514,340 — 514,340 — 2016 10% - 11% Due on demand — 860,510 — 860,510 — 860,510 — 860,510 — 2017 10% Due on demand — 12,000 — 12,000 — — — — — $ 1,926,850 $ — $ 1,926,850 — $ 1,924,850 $ — $ 1,924,850 — Current $ 1,926,850 $ — $ 1,926,850 — $ 1,924,850 $ — $ 1,924,850 — Non-current $ — $ — $ — — $ — $ — $ — — Convertible notes payable 2011 10% 5 years $3.05 $ 300,000 $ — $ 300,000 98,285 $ 300,000 $ — $ 300,000 98,285 2014 10% Due on demand - 2 years $3.05-$3.60 472,636 — 472,636 160,782 452,168 — 452,168 152,986 2015 10% 2 years $3.50-$3.60 2,279,226 28,731 2,250,495 693,814 2,904,800 104,389 2,800,411 889,115 2016 10% Due on demand — 1 year $3.50-$4.50 7,299,620 478,884 6,820,736 1,994,045 8,126,129 1,475,744 6,650,385 2,193,687 2017 10% Due on demand — 1 year $3.50-$7.60 1,834,848 1,192,134 642,714 493,089 — — — — $ 12,186,330 $ 1,699,749 $ 10,486,581 3,440,015 $ 11,783,097 $ 1,580,133 $ 10,202,964 3,334,073 Current $ 11,325,037 $ 1,541,550 $ 9,783,487 3,211,532 $ 10,499,303 $ 1,294,296 $ 9,205,007 2,984,161 Non-current $ 861,293 $ 158,199 $ 703,094 228,483 $ 1,283,794 $ 285,837 $ 997,957 349,912 Convertible notes payable - related party 2012 10% Due on demand $3.30 $ 254,000 $ — $ 254,000 78,888 $ 254,000 $ — $ 254,000 94,532 2015 10% 2 years $4.50 220,000 — 220,000 55,668 220,000 — 220,000 54,463 $ 474,000 $ — $ 474,000 134,556 $ 474,000 $ — $ 474,000 148,995 Current $ 474,000 $ — $ 474,000 134,556 $ 474,000 $ — $ 474,000 148,995 Non-current $ — $ — $ — — $ — $ — $ — — Grand Total $ 18,879,719 $ 1,699,749 $ 17,179,970 3,574,571 $ 18,276,376 $ 1,580,133 $ 16,696,243 3,483,068
Schedule of contractual principal payments of notes payable	Contractual principal payments due on notes payable are as follows: Year Ending March 31, 2017 2017 $ 17,473,957 2018 1,405,762 Total $ 18,879,719
Schedule of fair value assumptions for warrants issued in conjunction with notes	The Company estimated the total fair value of any beneficial conversion feature and accompanying warrants in allocating the note proceeds. The proceeds allocated to the beneficial conversion feature were determined by taking the estimated fair value of shares issuable under the convertible notes less the fair value of the number of shares that would be issued if the conversion rate equaled the fair value of Company common stock as of the date of issuance (see Note 2). The fair value of the warrants issued in conjunction with notes was determined using the Black Scholes Merton Option Pricing Model with the following inputs for the periods ended December 31, 2016. The Company did not issue any warrants in conjunction with notes in the three months ended March 31, 2017. December 31, 2016 Stock price $ 5.00 Exercise price $ 4.50 - 4.70 Term 5 years Risk-free interest rate 1.01 - 1.28 % Expected dividend yield — Expected volatility 65.4 - 69.6 %

STOCKHOLDERS' DEFICIT (Tables)

STOCKHOLDERS' DEFICIT (Tables)	3 Months Ended
STOCKHOLDERS' DEFICIT (Tables)	Mar. 31, 2017
Stockholders' Equity Note [Abstract]
Schedule of outstanding warrants	A summary of outstanding warrants as of March 31, 2017 and December 31, 2016 is presented below: Three months ended March 31, 2017 Year ended December 31, 2016 Warrants outstanding, beginning of period 5,024,668 3,530,918 Granted — 1,493,750 Exercised — — Cancelled, forfeited or expired — — Warrants outstanding, end of period 5,024,668 5,024,668 A summary of outstanding warrants by year issued and exercise price as of March 31, 2017 is presented below: Outstanding Exercisable Exercise Price Number of Warrants Issued Weighted Average Remaining Contractual Life (Years) Weighted Average Exercise Price Total Weighted Average Exercise Price At December 31, 2013 $ 3.30 50,000 1.08 $ 3.30 50,000 $ 3.30 $ 3.50 2,225,036 1.45 $ 3.50 2,225,036 $ 3.50 2013 total 2,275,036 2,275,036 At December 31, 2014 $ 3.50 1,145,465 1.48 $ 3.50 1,145,465 $ 3.50 2014 total 1,145,465 1,145,465 At December 31, 2015 $ 4.90 110,417 2.93 $ 4.90 110,417 $ 4.90 2015 total 110,417 110,417 At December 31, 2016 $ 4.50 118,750 4.25 $ 4.50 118,750 $ 4.50 $ 4.70 75,000 4.09 $ 4.70 75,000 $ 4.70 $ 5.00 1,300,000 4.11 $ 5.00 1,300,000 $ 5.00 2016 Total 1,493,750 1,493,750 Total 5,024,668 5,024,668
Schedule of outstanding options	Summaries of outstanding options as of March 31, 2017 and December 31, 2016 are presented below. March 31, 2017 December 31, 2016 Number of Options Weighted- Average Exercise Price Number of Options Weighted- Average Exercise Price Options outstanding, beginning of period 6,955,200 $ 4.10 4,753,335 $ 3.60 Granted or deemed issued — $ — 2,596,200 $ 4.97 Exercised — $ — (15,866 ) $ 3.60 Cancelled, forfeited and expired — $ — (378,469 ) $ 3.91 Options outstanding, end of period 6,955,200 $ 4.10 6,955,200 $ 4.10 Options exercisable, end of period 4,503,000 $ 3.62 4,372,667 $ 3.59 Options available for future grant, end of period 2,044,800 2,044,800

COMMITMENTS AND CONTINGENCIES (

COMMITMENTS AND CONTINGENCIES (Tables)	3 Months Ended
COMMITMENTS AND CONTINGENCIES (Tables)	Mar. 31, 2017
Commitments and Contingencies Disclosure [Abstract]
Schedule of future minimum lease payments	Future minimum lease payments under the agreements are as follows as of March 31, 2017: Year Amount 2017 (nine months) $ 413,194 2018 537,279 2019 126,115 $ 1,076,588

RELATED PARTY TRANSACTIONS (Tab

RELATED PARTY TRANSACTIONS (Tables)	3 Months Ended
RELATED PARTY TRANSACTIONS (Tables)	Mar. 31, 2017
Related Party Transactions [Abstract]
Schedule of outstanding loans from related parties	The following table sets forth information relating to the Company’s loans from related parties outstanding as of March 31, 2017. Class Lender Annual Interest Rate Date of Loan Term of Loan Principal Amount Outstanding at March 31, 2017 Highest Principal Outstanding Amount of Principal Repaid or Converted into Stock Amount of Interest Paid Conversion Rate Shares Underlying Notes at March 31, 2017 Notes payable to related parties—current: Hope Hospice(1) 8 % 1/17/2012 Due on demand $ 200,000 $ 200,000 $ — $ 4,000 $ — — Hope Hospice(1) 8 % 6/14/2012 Due on demand 200,000 200,000 — — — — Hope Hospice(1) 8 % 6/21/2012 Due on demand 100,000 100,000 — — — — Hope Hospice(1) 8 % 2/11/2013 Due on demand 50,000 50,000 — — — — Hope Hospice(1) 10 % 1/7/2015 Due on demand 100,000 100,000 — — — — IRA Service Trust Co. FBO Peter B. Ludlum(2) 10 % 2/20/2015 Due on demand 10,000 10,000 — — — — Yutaka Niihara(2)(3) 10 % 5/21/2015 Due on demand 94,340 826,105 731,765 — — — Masaharu & Emiko Osato(3) 11 % 12/29/2015 Due on demand 300,000 300,000 — — — — Lan T. Tran(2) 11 % 2/10/2016 Due on demand 130,510 130,510 — — — — Masaharu & Emiko Osato(3) 11 % 2/25/2016 Due on demand 400,000 400,000 — — — — Hope Hospice(1) 10 % 4/4/2016 Due on demand 50,000 50,000 — — — — Lan T. Tran(2) 10 % 4/29/2016 Due on demand 20,000 20,000 — — — — IRA Service Trust Co. FBO Peter B. Ludlum(2) 10 % 5/5/2016 Due on demand 10,000 10,000 — — — — Hope Hospice(1) 10 % 6/3/2016 Due on demand 250,000 250,000 — — — — Lan T. Tran(2) 10 % 2/9/2017 Due on demand 12,000 12,000 — — — — Sub total $ 1,926,850 $ 2,658,615 $ 731,765 $ 4,000 $ — — Convertible notes payable to related parties—current: Yasushi Nagasaki(2) 10 % 6/29/2012 Due on demand $ 254,000 $ 388,800 $ 134,800 $ 57,886 $ 3.30 78,888 Charles & Kimxa Stark(2) 10 % 10/1/2015 2 years 20,000 20,000 — — 4.50 5,111 Yutaka & Soomi Niihara(2)(3) 10 % 11/16/2015 2 years 200,000 200,000 — — 4.50 50,557 Sub total $ 474,000 $ 608,800 $ 134,800 $ 57,886 — 134,556 Total $ 2,400,850 $ 3,267,415 $ 866,565 $ 61,886 — 134,556 (1) Dr. Niihara, a director and officer of the Company, is also the Chief Executive Officer of Hope Hospice. (2) Officer. (3) Director. (4) Family of Officer/Director. The following table sets forth information relating to the Company’s loans from related persons outstanding as of December 31, 2016. Class Lender Annual Interest Rate Date of Loan Term of Loan Principal Amount Outstanding at December 31, 2016 Highest Principal Outstanding Amount of Principal Repaid or Converted into Stock Amount of Interest Paid Conversion Rate Shares Underlying Notes at December 31, 2016 Notes payable to related parties—current: Hope Hospice(1) 8 % 1/17/2012 Due on demand $ 200,000 $ 200,000 $ — $ 20,000 $ — — Hope Hospice(1) 8 % 6/14/2012 Due on demand 200,000 200,000 — 20,000 — — Hope Hospice(1) 8 % 6/21/2012 Due on demand 100,000 100,000 — 10,000 — — Hope Hospice(1) 8 % 2/11/2013 Due on demand 50,000 50,000 — 5,000 — — Hope Hospice(1) 10 % 1/7/2015 Due on demand 100,000 100,000 — — — — Lan T. Tran(2) 10 % 2/9/2015 Due on demand 10,000 10,000 — — — — IRA Service Trust Co. FBO Peter B. Ludlum(2) 10 % 2/20/2015 Due on demand 10,000 10,000 — — — — Yutaka Niihara(2)(3) 10 % 5/21/2015 Due on demand 94,340 826,105 731,765 47,822 — — Masaharu & Emiko Osato(3) 11 % 12/29/2015 Due on demand 300,000 300,000 — — — — Lan T. Tran(2) 11 % 2/10/2016 Due on demand 130,510 130,510 — — — — Hideki & Eiko Uehara(4) 11 % 2/15/2016 Due on demand — 133,333 133,333 12,226 — — Masaharu & Emiko Osato(3) 11 % 2/25/2016 Due on demand 400,000 400,000 — — — — Hope Hospice(1) 10 % 4/4/2016 Due on demand 50,000 50,000 — — — — Willis C. Lee(2)(3) 10 % 4/8/2016 Due on demand — 79,700 79,700 1,288 — — Lan T. Tran(2) 10 % 4/29/2016 Due on demand 20,000 20,000 — — — — IRA Service Trust Co. FBO Peter B. Ludlum(2) 10 % 5/5/2016 Due on demand 10,000 10,000 — — — — Hope Hospice(1) 10 % 6/3/2016 Due on demand 250,000 250,000 — — — — Sub total $ 1,924,850 $ 2,869,648 $ 944,798 $ 116,336 $ — — Convertible notes payable to related parties—current: Yasushi Nagasaki(2) 10 % 6/29/2012 Due on demand $ 254,000 $ 388,800 $ 134,800 $ 27,824 $ 3.30 94,532 Charles & Kimxa Stark(2) 10 % 10/1/2015 2 years 20,000 20,000 — — 4.50 5,002 Yutaka & Soomi Niihara(2)(3) 10 % 11/16/2015 2 years 200,000 200,000 — — 4.50 49,461 Sub total $ 474,000 $ 608,800 $ 134,800 $ 27,824 — 148,995 Total $ 2,398,850 $ 3,478,448 $ 1,079,598 $ 144,160 — 148,995 (1) Dr. Niihara, who is the Company’s CEO, is also the CEO of Hope Hospice. (2) Officer (3) Director (4) Family of Officer/Director

GEOGRAPHIC INFORMATION (Tables)

GEOGRAPHIC INFORMATION (Tables)	3 Months Ended
GEOGRAPHIC INFORMATION (Tables)	Mar. 31, 2017
Segment Reporting [Abstract]
Schedule of revenue earned from countries outside of the United States	For the three months ended March 31, 2017 and 2016, the Company earned revenue from countries outside of the United States as outlined in the table below: Country Revenues for the three months ended March 31, 2017 % of total revenue for the three months ended March 31, 2017 Revenues for the three months ended March 31, 2016 % of total revenue for the three months ended March 31, 2016 Japan $ 28,558 27 % $ 51,074 64 % Taiwan 64,300 60 % 25,211 32 %

SUBSEQUENT EVENTS (Tables)

SUBSEQUENT EVENTS (Tables)	3 Months Ended
SUBSEQUENT EVENTS (Tables)	Mar. 31, 2017
Subsequent Events [Abstract]
Schedule of subsequent events	Subsequent to March 31, 2017, the Company issued the following: Note issued after March 31, 2017 Amount Annual Interest Rate Term of Note Conversion Price Convertible notes $ 4,085,587 10.00 % Due on demand ~ 2 Years $ 3.50 Convertible notes $ 555,591 10.00 % 2 years $ 3.60 Promissory note $ 1,500,000 11.00 % Due on demand ~ 2 Years — Total $ 6,141,178 Subsequent to March 31, 2017, the Company issued the following: Common Shares Issued after March 31, 2017 Amount Number of Shares Issued Common shares $ 212,800 28,000 Total $ 212,800 28,000

SUMMARY OF SIGNIFICANT ACCOUN27

SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Details) - USD ($)	Mar. 31, 2017	Dec. 31, 2016
Accounting Policies [Abstract]
Work-in-process	$ 139,181	$ 34,462
Finished goods	122,241	131,747
Total	$ 261,422	$ 166,209

SUMMARY OF SIGNIFICANT ACCOUN28

SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Details 1) - USD ($)	Mar. 31, 2017	Dec. 31, 2016
Accounting Policies [Abstract]
Prepaid insurance	$ 65,016	$ 100,060
Other prepaid expenses and current assets	36,081	29,144
Prepaid expenses and other current assets	$ 101,097	$ 129,204

SUMMARY OF SIGNIFICANT ACCOUN29

SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Details 2) - Warrant Derivative Liabilities - Stock Purchase Warrants [Member] - USD ($)	3 Months Ended	12 Months Ended
	Mar. 31, 2017	Dec. 31, 2016
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Balance, beginning of period	$ 10,600,000	$ 7,863,000
Change in fair value included in consolidated statements of comprehensive loss	1,228,000	2,737,000
Balance, end of period	$ 11,828,000	$ 10,600,000

SUMMARY OF SIGNIFICANT ACCOUN30

SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Details 3) - USD ($)	Sep. 11, 2013	Mar. 31, 2017	Dec. 31, 2016
Balance, end of period:
Warrant derivative liabilities		$ 11,828,000	$ 10,600,000
Warrants [Member]
Stock price	$ 3.60	$ 6.60	$ 6
Risk-free interest rate	1.72%	1.14%	1.09%
Expected volatility (peer group)	72.40%	64.70%	68.30%
Expected life (in years)	5 years	1 year 5 months 12 days	1 year 8 months 12 days
Number outstanding	3,320,501	3,320,501	3,320,501
Balance, end of period:
Liability classified warrants	$ 7,541,000
Warrant derivative liabilities		$ 11,828,000	$ 10,600,000

SUMMARY OF SIGNIFICANT ACCOUN31

SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Details 4)	3 Months Ended
SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Details 4)	Mar. 31, 2017USD ($)$ / shares$ / Warrantsshares
Original Loan Principal Amount	$ 12,701,139
Beneficial Conversion Discount Amount	$ 4,507,810
Warrants Issued with Notes (in shares) \| shares	75,000
Warrant FMV Discount Amount	$ 161,658
Minimum [Member]
Conversion Rate (in dollars per share) \| $ / shares	$ 3.05
Maximum [Member]
Conversion Rate (in dollars per share) \| $ / shares	$ 3.60
2016 Convertible Notes Payable [Member]
Stated Annual Interest Rate	10.00%
Original Loan Principal Amount	$ 10,866,291
Beneficial Conversion Discount Amount	$ 3,196,544
Warrants Issued with Notes (in shares) \| shares	75,000
Exercise Price (in dollars per share) \| $ / Warrants	4.70
Warrant FMV Discount Amount	$ 161,658
2016 Convertible Notes Payable [Member] \| Minimum [Member]
Conversion Rate (in dollars per share) \| $ / shares	$ 3.50
Effective Interest Rate Including Discounts	14.00%
2016 Convertible Notes Payable [Member] \| Maximum [Member]
Conversion Rate (in dollars per share) \| $ / shares	$ 4.50
Effective Interest Rate Including Discounts	102.00%
2017 Convertible Notes Payable [Member]
Stated Annual Interest Rate	10.00%
Original Loan Principal Amount	$ 1,834,848
Beneficial Conversion Discount Amount	$ 1,311,266
2017 Convertible Notes Payable [Member] \| Minimum [Member]
Conversion Rate (in dollars per share) \| $ / shares	$ 3.50
Effective Interest Rate Including Discounts	10.00%
2017 Convertible Notes Payable [Member] \| Maximum [Member]
Conversion Rate (in dollars per share) \| $ / shares	$ 7.60
Effective Interest Rate Including Discounts	99.00%

SUMMARY OF SIGNIFICANT ACCOUN32

SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Details Narrative)	Oct. 31, 2016USD ($)	Oct. 31, 2016KRW (₩)₩ / shares	Jan. 31, 2009USD ($)shares	Jan. 31, 2009JPY (¥)¥ / sharesshares	Mar. 31, 2017USD ($)$ / sharesshares	Mar. 31, 2016USD ($)shares	Mar. 31, 2017₩ / shares	Mar. 31, 2017¥ / shares	Dec. 31, 2016$ / shares	Dec. 31, 2016₩ / shares	Dec. 31, 2016¥ / shares
Advertising costs					$ 8,391	$ 3,939
Potentially dilutive securities outstanding \| shares					15,554,439	11,837,427
Other current liabilities					$ 4,019,728
Generex Biotechnology Corporation [Member]
Other current liabilities					4,000,000
2011 Convertible notes payable [Member]
Convertible notes payable, carrying amount					$ 300,000
Cell Seed Inc [Member]
Shares held as marketable securities \| shares					39,250
Shares originally purchased (in shares) \| shares			147,100	147,100
Investment			$ 1,109,819
Investment, closing price \| $ / shares					$ 5.03				$ 4.58
Stock pledged against note \| shares					39,250
Cell Seed Inc [Member] \| Japan, Yen
Investment \| ¥				¥ 100,028,000
Investment, in per share \| ¥ / shares				¥ 680
Investment, closing price \| ¥ / shares								¥ 560			¥ 536
KPM Tech [Member]
Shares held as marketable securities \| shares					849,744
Investment	$ 13,000,000
Investment, closing price \| $ / shares					$ 12.14				12.08
KPM Tech [Member] \| Korea (South), Won
Investment \| ₩		₩ 14,318,186,400
Investment, in per share \| ₩ / shares		₩ 16,850
Investment, closing price \| ₩ / shares							₩ 13,550			₩ 14,600
Hanil Vacuum [Member]
Shares held as marketable securities \| shares					271,950
Investment	$ 1,000,000
Investment, closing price \| $ / shares					$ 2.33				$ 2.40
Hanil Vacuum [Member] \| Korea (South), Won
Investment \| ₩		₩ 1,101,397,500
Investment, in per share \| ₩ / shares		₩ 4,050
Investment, closing price \| ₩ / shares							₩ 2,595			₩ 2,895

PROPERTY AND EQUIPMENT (Details

PROPERTY AND EQUIPMENT (Details) - USD ($)	Mar. 31, 2017	Dec. 31, 2016
Property and equipment
Property and equipment, gross	$ 325,970	$ 280,974
Less: accumulated depreciation	(232,962)	(227,244)
Property and equipment, net	93,008	53,730
Equipment [Member]
Property and equipment
Property and equipment, gross	180,914	175,410
Leasehold Improvements [Member]
Property and equipment
Property and equipment, gross	69,189	30,804
Furniture and Fixtures [Member]
Property and equipment
Property and equipment, gross	$ 75,867	$ 74,760

PROPERTY AND EQUIPMENT (Detai34

PROPERTY AND EQUIPMENT (Details Narrative) - USD ($)	3 Months Ended
PROPERTY AND EQUIPMENT (Details Narrative) - USD ($)	Mar. 31, 2017	Mar. 31, 2016
Property, Plant and Equipment [Abstract]
Depreciation expense	$ 5,308	$ 3,668

ACCOUNTS PAYABLE AND ACCRUED 35

ACCOUNTS PAYABLE AND ACCRUED EXPENSES (Details) - USD ($)	Mar. 31, 2017	Dec. 31, 2016
Accounts payable
Clinical and regulatory expenses	$ 322,603	$ 145,239
Legal expenses	99,859	43,700
Consulting fees	191,473	99,800
Accounting fees	42,500	65,267
Selling expenses	24,991	60,724
Investor relations and public relations expenses	11,099	19,931
Other vendors	259,620	41,640
Total accounts payable	952,145	476,301
Accrued interest payable, related parties	262,766	274,851
Accrued interest payable	1,562,739	1,441,450
Accrued expenses	817,117	716,886
Deferred salary	291,666	291,666
Total accounts payable and accrued expenses	$ 3,886,433	$ 3,201,154

NOTES PAYABLE (Details)

NOTES PAYABLE (Details) - USD ($)	3 Months Ended
NOTES PAYABLE (Details) - USD ($)	Mar. 31, 2017	Dec. 31, 2016
Principal Outstanding	$ 18,879,719	$ 18,276,376
Discount Amount	1,699,749	1,580,133
Carrying Amount	17,179,970	16,696,243
Notes payable, current	$ 4,292,539	4,094,429
Minimum [Member]
Conversion price	$ 3.05
Maximum [Member]
Conversion price	$ 3.60
2013 Notes payable [Member]
Interest rate	10.00%
Term of Notes	Due on demand
Principal Outstanding	$ 897,400	854,900
Carrying Amount	$ 897,400	854,900
2015 Notes payable [Member]
Interest rate	11.00%
Term of Notes	Due on demand
Principal Outstanding	$ 1,948,700	2,406,194
Carrying Amount	$ 1,948,700	2,406,194
2016 Notes payable [Member]
Interest rate	11.00%
Term of Notes	Due on demand
Principal Outstanding	$ 833,335	833,335
Carrying Amount	$ 833,335	833,335
2017 Notes payable [Member]
Interest rate	11.00%
Term of Notes	Due on demand
Principal Outstanding	$ 613,104
Carrying Amount	613,104
Notes Payable [Member]
Principal Outstanding	4,292,539	4,094,429
Carrying Amount	4,292,539	4,094,429
Principal Outstanding, current	4,292,539	4,094,429
Notes payable, current	$ 4,292,539	4,094,429
2012 Notes payable - related party [Member]
Interest rate	8.00%
Term of Notes	Due on demand
Principal Outstanding	$ 500,000	500,000
Carrying Amount	$ 500,000	500,000
2013 Notes payable - related party [Member]
Interest rate	8.00%
Term of Notes	Due on demand
Principal Outstanding	$ 50,000	50,000
Carrying Amount	$ 50,000	50,000
2015 Notes payable - related party [Member]
Term of Notes	Due on demand
Principal Outstanding	$ 504,340	514,340
Carrying Amount	$ 504,340	514,340
2015 Notes payable - related party [Member] \| Minimum [Member]
Interest rate	10.00%
2015 Notes payable - related party [Member] \| Maximum [Member]
Interest rate	11.00%
2016 Notes payable - related party [Member]
Term of Notes	Due on demand
Principal Outstanding	$ 860,510	860,510
Carrying Amount	$ 860,510	860,510
2016 Notes payable - related party [Member] \| Minimum [Member]
Interest rate	10.00%
2016 Notes payable - related party [Member] \| Maximum [Member]
Interest rate	11.00%
2017 Notes payable - related party [Member]
Interest rate	10.00%
Term of Notes	Due on demand
Principal Outstanding	$ 12,000
Carrying Amount	12,000
Notes payable - related party [Member]
Principal Outstanding	1,926,850	1,924,850
Carrying Amount	1,926,850	1,924,850
Principal Outstanding, current	1,926,850	1,924,850
Notes payable, current	$ 1,926,850	$ 1,924,850

NOTES PAYABLE (Details 1)

NOTES PAYABLE (Details 1)	3 Months Ended	12 Months Ended
NOTES PAYABLE (Details 1)	Mar. 31, 2017USD ($)Number$ / shares	Dec. 31, 2016USD ($)Number
Principal Outstanding	$ 18,879,719	$ 18,276,376
Discount Amount	1,699,749	1,580,133
Total Carrying Amount	$ 17,179,970	$ 16,696,243
Shares Underlying Principal \| Number	3,574,571	3,483,068
Convertible notes payable, Current	$ 9,783,487	$ 9,205,007
Convertible notes payable, Non Current	$ 703,094	997,957
Minimum [Member]
Conversion price \| $ / shares	$ 3.05
Maximum [Member]
Conversion price \| $ / shares	$ 3.60
2011 Convertible notes payable [Member]
Interest rate	10.00%
Term of Notes	5 years
Conversion price \| $ / shares	$ 3.05
Principal Outstanding	$ 300,000	300,000
Total Carrying Amount	$ 300,000	$ 300,000
Shares Underlying Principal \| Number	98,285	98,285
2014 Convertible notes payable [Member]
Interest rate	10.00%
Term of Notes	Due on demand - 2 years
Term of Notes	2 years
Principal Outstanding	$ 472,636	$ 452,168
Total Carrying Amount	$ 472,636	$ 452,168
Shares Underlying Principal \| Number	160,782	152,986
2014 Convertible notes payable [Member] \| Minimum [Member]
Conversion price \| $ / shares	$ 3.05
2014 Convertible notes payable [Member] \| Maximum [Member]
Conversion price \| $ / shares	$ 3.60
2015 Convertible notes payable [Member]
Interest rate	10.00%
Term of Notes	2 years
Principal Outstanding	$ 2,279,226	$ 2,904,800
Discount Amount	28,731	104,389
Total Carrying Amount	$ 2,250,495	$ 2,800,411
Shares Underlying Principal \| Number	693,814	889,115
2015 Convertible notes payable [Member] \| Minimum [Member]
Conversion price \| $ / shares	$ 3.50
2015 Convertible notes payable [Member] \| Maximum [Member]
Conversion price \| $ / shares	$ 3.60
2016 Convertible Notes Payable [Member]
Interest rate	10.00%
Term of Notes	Due on demand -1 year
Term of Notes	1 year
Principal Outstanding	$ 7,299,620	$ 8,126,129
Discount Amount	478,884	1,475,744
Total Carrying Amount	$ 6,820,736	$ 6,650,385
Shares Underlying Principal \| Number	1,994,045	2,193,687
2016 Convertible Notes Payable [Member] \| Minimum [Member]
Conversion price \| $ / shares	$ 3.50
2016 Convertible Notes Payable [Member] \| Maximum [Member]
Conversion price \| $ / shares	$ 4.50
2017 Convertible Notes Payable [Member]
Interest rate	10.00%
Term of Notes	Due on demand - 1 year
Term of Notes	1 year
Principal Outstanding	$ 1,834,848
Discount Amount	1,192,134
Total Carrying Amount	$ 642,714
Shares Underlying Principal \| Number	493,089
2017 Convertible Notes Payable [Member] \| Minimum [Member]
Conversion price \| $ / shares	$ 3.50
2017 Convertible Notes Payable [Member] \| Maximum [Member]
Conversion price \| $ / shares	$ 7.60
Convertible Notes Payable [Member]
Principal Outstanding	$ 12,186,330	$ 11,783,097
Discount Amount	1,699,749	1,580,133
Total Carrying Amount	$ 10,486,581	$ 10,202,964
Shares Underlying Principal \| Number	3,440,015	3,334,073
Principal Outstanding, Current	$ 11,325,037	$ 10,499,303
Principal Outstanding, Non Current	861,293	1,283,794
Discount Amount Current	1,541,550	1,294,296
Discount Amount Non Current	158,199	285,837
Convertible notes payable, Current	9,783,487	9,205,007
Convertible notes payable, Non Current	$ 703,094	$ 997,957
Shares Underlying Principal Current \| Number	3,211,532	2,984,161
Shares Underlying Principal Non Current \| Number	228,483	349,912
2012 Convertible notes payable - related party [Member]
Interest rate	10.00%
Term of Notes	Due on demand
Conversion price \| $ / shares	$ 3.30
Principal Outstanding	$ 254,000	$ 254,000
Total Carrying Amount	$ 254,000	$ 254,000
Shares Underlying Principal \| Number	78,888	94,532
2015 Convertible notes payable - related party [Member]
Interest rate	10.00%
Term of Notes	2 years
Conversion price \| $ / shares	$ 4.50
Principal Outstanding	$ 220,000	$ 220,000
Total Carrying Amount	$ 220,000	$ 220,000
Shares Underlying Principal \| Number	55,668	54,463
Convertible notes payable - related party [Member]
Principal Outstanding	$ 474,000	$ 474,000
Total Carrying Amount	$ 474,000	$ 474,000
Shares Underlying Principal \| Number	134,556	148,995
Principal Outstanding, Current	$ 474,000	$ 474,000
Convertible notes payable related parties, Current	$ 474,000	$ 474,000
Shares Underlying Principal Current \| Number	134,556	148,995

NOTES PAYABLE (Details 2)

NOTES PAYABLE (Details 2)	Mar. 31, 2017USD ($)
Contractual principal payments due on loans and notes payable for the year ending
2,017	$ 17,473,957
2,018	1,405,762
Total	$ 18,879,719

NOTES PAYABLE (Details 3)

NOTES PAYABLE (Details 3) - Warrants [Member] - $ / shares	Sep. 11, 2013	Mar. 31, 2017	Dec. 31, 2016
Stock price	$ 3.60	$ 6.60	$ 6
Term	5 years	1 year 5 months 12 days	1 year 8 months 12 days
Risk-free interest rate	1.72%	1.14%	1.09%
Expected volatility	72.40%	64.70%	68.30%
Convertible Notes Payable [Member]
Stock price			$ 5
Term			5 years
Convertible Notes Payable [Member] \| Minimum [Member]
Exercise Price			$ 4.50
Risk-free interest rate			1.01%
Expected volatility			65.40%
Convertible Notes Payable [Member] \| Maximum [Member]
Exercise Price			$ 4.70
Risk-free interest rate			1.28%
Expected volatility			69.60%

NOTES PAYABLE (Details Narrativ

NOTES PAYABLE (Details Narrative) - $ / shares	3 Months Ended
NOTES PAYABLE (Details Narrative) - $ / shares	Mar. 31, 2017	Dec. 31, 2016
Average stated interest rate	10.00%	10.00%
Average effective interest rate	28.00%	27.00%
Description of debt conversion	Certain notes with a $4.50 or a $7.00 stated conversion price in the second year of their two-year term are subject to automatic conversion into shares of Company common stock at a conversion price equal to 80% of the initial public offering price at the time of a qualified public offering.
Warrants [Member]
Method of calculation of fair value of warrants	Black-Scholes-Merton option pricing model
Minimum [Member]
Conversion price	$ 3.05
Maximum [Member]
Conversion price	$ 3.60

STOCKHOLDERS' DEFICIT (Details)

STOCKHOLDERS' DEFICIT (Details) - shares	3 Months Ended	12 Months Ended
STOCKHOLDERS' DEFICIT (Details) - shares	Mar. 31, 2017	Dec. 31, 2016
Warrants outstanding summary
Warrants outstanding, ending	5,024,668
Warrants [Member]
Warrants outstanding summary
Warrants outstanding, beginning	5,024,668	3,530,918
Granted		1,493,750
Warrants outstanding, ending	5,024,668	5,024,668

STOCKHOLDERS' DEFICIT (Details

STOCKHOLDERS' DEFICIT (Details 1)	3 Months Ended
STOCKHOLDERS' DEFICIT (Details 1)	Mar. 31, 2017Numbershares
Outstanding
Warrants outstanding	5,024,668
Exercisable	5,024,668
Warrants Issued in 2013 - Exercise Price $3.30 [Member]
Outstanding
Warrants outstanding	50,000
Weighted Average Remaining Contractual Life (Years)	1 year 29 days
Weighted Average Exercise Price \| Number	3.30
Exercisable	50,000
Weighted Average Exercise Price \| Number	3.30
Warrants Issued in 2013 - Exercise Price $3.50 [Member]
Outstanding
Warrants outstanding	2,225,036
Weighted Average Remaining Contractual Life (Years)	1 year 5 months 12 days
Weighted Average Exercise Price \| Number	3.50
Exercisable	2,225,036
Weighted Average Exercise Price \| Number	3.50
Warrants Issued in 2013 [Member]
Outstanding
Warrants outstanding	2,275,036
Exercisable	2,275,036
Warrants Issued in 2014 - Exercise Price $3.50 [Member]
Outstanding
Warrants outstanding	1,145,465
Weighted Average Remaining Contractual Life (Years)	1 year 5 months 23 days
Weighted Average Exercise Price \| Number	3.50
Exercisable	1,145,465
Weighted Average Exercise Price \| Number	3.50
Warrants Issued in 2014 [Member]
Outstanding
Warrants outstanding	1,145,465
Exercisable	1,145,465
Warrants Issued in 2015 - Exercise Price $4.90 [Member]
Outstanding
Warrants outstanding	110,417
Weighted Average Remaining Contractual Life (Years)	2 years 11 months 5 days
Weighted Average Exercise Price \| Number	4.90
Exercisable	110,417
Weighted Average Exercise Price \| Number	4.90
Warrants Issued in 2015 [Member]
Outstanding
Warrants outstanding	110,417
Exercisable	110,417
Warrants Issued in 2016 - Exercise Price $4.50 [Member]
Outstanding
Warrants outstanding	118,750
Weighted Average Remaining Contractual Life (Years)	4 years 3 months
Weighted Average Exercise Price \| Number	4.50
Exercisable	118,750
Weighted Average Exercise Price \| Number	4.50
Warrants Issued in 2016 - Exercise Price $4.70 [Member]
Outstanding
Warrants outstanding	75,000
Weighted Average Remaining Contractual Life (Years)	4 years 1 month 2 days
Weighted Average Exercise Price \| Number	4.70
Exercisable	75,000
Weighted Average Exercise Price \| Number	4.70
Warrants Issued in 2016 - Exercise Price $5.00 [Member]
Outstanding
Warrants outstanding	1,300,000
Weighted Average Remaining Contractual Life (Years)	4 years 4 months 10 days
Weighted Average Exercise Price \| Number	5
Exercisable	1,300,000
Weighted Average Exercise Price \| Number	5
Warrants Issued in 2016 [Member]
Outstanding
Warrants outstanding	1,493,750
Exercisable	1,493,750

STOCKHOLDERS' DEFICIT (Detail43

STOCKHOLDERS' DEFICIT (Details 2) - $ / shares	3 Months Ended	12 Months Ended
STOCKHOLDERS' DEFICIT (Details 2) - $ / shares	Mar. 31, 2017	Dec. 31, 2016
Options, Outstanding [Roll Forward]
Granted or deemed issued	2,596,200
2011 Stock Incentive Option Plan [Member]
Options, Outstanding [Roll Forward]
Options outstanding, beginning	6,955,200	4,753,335
Granted or deemed issued		2,596,200
Exercised		(15,866)
Cancelled, forfeited and expired		(378,469)
Options outstanding, end	6,955,200	6,955,200
Options exercisable	4,503,000	4,372,667
Options available for future grant	2,044,800	2,044,800
Weighted Average Exercise Price [Roll Forward]
Options outstanding, beginning	$ 4.10	$ 3.60
Granted or deemed issued		4.97
Exercised		3.60
Cancelled, forfeited and expired		3.91
Options outstanding, end	4.10	4.10
Options exercisable	$ 3.62	$ 3.59

STOCKHOLDERS' DEFICIT (Detail44

STOCKHOLDERS' DEFICIT (Details Narrative) - USD ($)	Sep. 12, 2016	Jun. 10, 2014	Sep. 11, 2013	Mar. 31, 2017	Mar. 31, 2016	Dec. 31, 2016	Dec. 31, 2015	Jun. 10, 2015	Sep. 11, 2014
Warrants outstanding				5,024,668
Fair value of outstanding warrants				$ 11,828,000
Issuance of warrants (in shares)				75,000
Options granted				2,596,200
Share-based compensation				$ 1,028,350	$ 540,516
KPM Tech Co., Ltd [Member] \| Letter of Agreement [Member]
Common stock price	$ 15.32
Future capital increases	$ 13,000,000
Hanil Vacuum Co Ltd [Member] \| Letter of Agreement [Member]
Common stock price	$ 3.68
Future capital increases	$ 1,000,000
2011 Stock Incentive Option Plan [Member]
Options granted						2,596,200
Exercise price - options				$ 4.10		$ 4.10	$ 3.60
Options outstanding				6,955,200		6,955,200	4,753,335
Total unrecognized compensation cost				$ 7,000,000
Period remaining for recognition of unrecognized compensation cost				1 year 10 months 24 days
2011 Stock Incentive Option Plan [Member] \| 2016 Stock Options Tranche 1 [Member]
Options granted				300,000
Exercise price - options				$ 4.70
Vesting percentage				33.00%
2011 Stock Incentive Option Plan [Member] \| 2016 Stock Options Tranche 2 [Member]
Options granted				2,296,200
Exercise price - options				$ 5
Vesting percentage				33.00%
2011 Stock Incentive Option Plan [Member] \| Stock Options [Member]
Expiration period				10 years
Vesting period				3 years
Share-based compensation				$ 1,000,000	$ 500,000
Warrants [Member]
Warrants outstanding				3,320,501
Share price			$ 3.60	$ 6.60		$ 6
Cashless Exercise Warrants [Member]
Number of shares callable by warrants				1,791,323
Cashless Exercise Warrants [Member] \| Minimum [Member]
Share price				$ 6.60
Cashless Exercise Warrants [Member] \| Maximum [Member]
Share price				$ 7.60
Private Placement [Member]
Units issued in offering (in units)			3,020,501
Unit price of offering (in dollars per share)			2.50
Units issued in offering			$ 7,551,253
Warrants issued to broker of the offering			300,000
Exercise price		$ 3.50	$ 3.50
Warrants outstanding									2,225,036
Fair value of outstanding warrants		$ 1,800,000							$ 7,068,000
Number of warrants exercised		1,095,465
Proceeds from exercise of warrants		$ 3,800,000
Issuance of common stock for exercise of warrants		1,095,465
Adjustment ot additional paid-in capital - warrants		$ 1,800,000
Number of registrable securities (in shares)									4,115,966
Private Placement [Member] \| Letter of Agreement [Member]
Common stock price	$ 4.50
Reduction in additional paid in capital	$ 720,000
Private Placement [Member] \| KPM Tech Co., Ltd [Member] \| Letter of Agreement [Member]
Purchase of common stock	$ 17,000,000
Common stock price	$ 4.50
Future capital investment	$ 13,000,000
Number of shares issued	3,777,778
Private Placement [Member] \| Hanil Vacuum Co Ltd [Member] \| Letter of Agreement [Member]
Purchase of common stock	$ 3,000,000
Common stock price	$ 4.50
Future capital investment	$ 1,000,000
Number of shares issued	666,667
Private Placement [Member] \| Replacement Warrants [Member]
Exercise price		$ 3.50
Warrants outstanding								1,095,465
Fair value of outstanding warrants								$ 2,545,000
Issuance of warrants (in shares)		1,095,465
Warrant exercise inducement expense		$ 3,500,000
Private Placement [Member] \| Warrants [Member]
Number of registrable securities (in shares)									3,320,501

COMMITMENTS AND CONTINGENCIES45

COMMITMENTS AND CONTINGENCIES (Details)	Mar. 31, 2017USD ($)
Future minimum lease payments
2017 (nine months)	$ 413,194
2,018	537,279
2,019	126,115
Total	$ 1,076,588

COMMITMENTS AND CONTINGENCIES46

COMMITMENTS AND CONTINGENCIES (Details Narrative) - USD ($)	3 Months Ended
COMMITMENTS AND CONTINGENCIES (Details Narrative) - USD ($)	Mar. 31, 2017	Mar. 31, 2016
Commitments and Contingencies Disclosure [Abstract]
Monthly commercialization management fee	$ 4,500
Rent expense	$ 151,312	$ 144,364

RELATED PARTY TRANSACTIONS (Det

RELATED PARTY TRANSACTIONS (Details)		3 Months Ended	12 Months Ended
RELATED PARTY TRANSACTIONS (Details)		Mar. 31, 2017USD ($)Number$ / shares	Dec. 31, 2016USD ($)Number$ / shares
Short-term Debt [Line Items]
Principal Amount Outstanding		$ 17,179,970	$ 16,696,243
Shares Underlying Principal \| Number		3,574,571	3,483,068
Less discount		$ (1,699,749)	$ (1,580,133)
Total		$ 18,879,719
Hope Hospice [Member]
Short-term Debt [Line Items]
Annual Interest Rate	[1]	8.00%	8.00%
Date of Loan	[1]	Jan. 17, 2012	Jan. 17, 2012
Term of Loan	[1]	Due on demand	Due on demand
Principal Amount Outstanding	[1]	$ 200,000	$ 200,000
Highest Principal Outstanding	[1]	200,000	200,000
Amount of Interest Paid	[1]	$ 4,000	$ 20,000
Hope Hospice [Member]
Short-term Debt [Line Items]
Annual Interest Rate	[1]	8.00%	8.00%
Date of Loan	[1]	Jun. 14, 2012	Jun. 14, 2012
Term of Loan	[1]	Due on demand	Due on demand
Principal Amount Outstanding	[1]	$ 200,000	$ 200,000
Highest Principal Outstanding	[1]	$ 200,000	200,000
Amount of Interest Paid	[1]		$ 20,000
Hope Hospice [Member]
Short-term Debt [Line Items]
Annual Interest Rate	[1]	8.00%	8.00%
Date of Loan	[1]	Jun. 21, 2012	Jun. 21, 2012
Term of Loan	[1]	Due on demand	Due on demand
Principal Amount Outstanding	[1]	$ 100,000	$ 100,000
Highest Principal Outstanding	[1]	$ 100,000	100,000
Amount of Interest Paid	[1]		$ 10,000
Hope Hospice [Member]
Short-term Debt [Line Items]
Annual Interest Rate	[1]	8.00%	8.00%
Date of Loan	[1]	Feb. 11, 2013	Feb. 11, 2013
Term of Loan	[1]	Due on demand	Due on demand
Principal Amount Outstanding	[1]	$ 50,000	$ 50,000
Highest Principal Outstanding	[1]	$ 50,000	50,000
Amount of Interest Paid	[1]		$ 5,000
Hope Hospice [Member]
Short-term Debt [Line Items]
Annual Interest Rate	[1]	10.00%	10.00%
Date of Loan	[1]	Jan. 7, 2015	Jan. 7, 2015
Term of Loan	[1]	Due on demand	Due on demand
Principal Amount Outstanding	[1]	$ 100,000	$ 100,000
Highest Principal Outstanding	[1]	$ 100,000	$ 100,000
IRA Service Trust Co. FBO Peter B. Ludlum [Member]
Short-term Debt [Line Items]
Annual Interest Rate	[2]	10.00%	10.00%
Date of Loan	[2]	Feb. 20, 2015	Feb. 20, 2015
Term of Loan	[2]	Due on demand	Due on demand
Principal Amount Outstanding	[2]	$ 10,000	$ 10,000
Highest Principal Outstanding	[2]	$ 10,000	$ 10,000
Yutaka Niihara [Member]
Short-term Debt [Line Items]
Annual Interest Rate	[2],[3]	10.00%	10.00%
Date of Loan	[2],[3]	May 21, 2015	May 21, 2015
Term of Loan	[2],[3]	Due on demand	Due on demand
Principal Amount Outstanding	[2],[3]	$ 94,340	$ 94,340
Highest Principal Outstanding	[2],[3]	826,105	826,105
Amount of Principal Repaid	[2],[3]	$ 731,765	731,765
Amount of Interest Paid	[2],[3]		$ 47,822
Masaharu & Emiko Osato [Member]
Short-term Debt [Line Items]
Annual Interest Rate	[3]	11.00%	11.00%
Date of Loan	[3]	Dec. 29, 2015	Dec. 29, 2015
Term of Loan	[3]	Due on demand	Due on demand
Principal Amount Outstanding	[3]	$ 300,000	$ 300,000
Highest Principal Outstanding	[3]	$ 300,000	$ 300,000
Lan T. Tran [Member]
Short-term Debt [Line Items]
Annual Interest Rate	[2]	11.00%	11.00%
Date of Loan	[2]	Feb. 10, 2016	Feb. 10, 2016
Term of Loan	[2]	Due on demand	Due on demand
Principal Amount Outstanding	[2]	$ 130,510	$ 130,510
Highest Principal Outstanding	[2]	$ 130,510	$ 130,510
Masaharu & Emiko Osato [Member]
Short-term Debt [Line Items]
Annual Interest Rate	[3]	11.00%	11.00%
Date of Loan	[3]	Feb. 25, 2016	Feb. 25, 2016
Term of Loan	[3]	Due on demand	Due on demand
Principal Amount Outstanding	[3]	$ 400,000	$ 400,000
Highest Principal Outstanding	[3]	$ 400,000	$ 400,000
Hope Hospice [Member]
Short-term Debt [Line Items]
Annual Interest Rate	[1]	10.00%	10.00%
Date of Loan	[1]	Apr. 4, 2016	Apr. 4, 2016
Term of Loan	[1]	Due on demand	Due on demand
Principal Amount Outstanding	[1]	$ 50,000	$ 50,000
Highest Principal Outstanding	[1]	$ 50,000	$ 50,000
Lan T. Tran [Member]
Short-term Debt [Line Items]
Annual Interest Rate	[2]	10.00%	10.00%
Date of Loan	[2]	Apr. 29, 2016	Apr. 29, 2016
Term of Loan	[2]	Due on demand	Due on demand
Principal Amount Outstanding	[2]	$ 20,000	$ 20,000
Highest Principal Outstanding	[2]	$ 20,000	$ 20,000
IRA Service Trust Co. FBO Peter B. Ludlum [Member]
Short-term Debt [Line Items]
Annual Interest Rate	[2]	10.00%	10.00%
Date of Loan	[2]	May 5, 2016	May 5, 2016
Term of Loan	[2]	Due on demand	Due on demand
Principal Amount Outstanding	[2]	$ 10,000	$ 10,000
Highest Principal Outstanding	[2]	$ 10,000	$ 10,000
Hope Hospice [Member]
Short-term Debt [Line Items]
Annual Interest Rate	[1]	10.00%	10.00%
Date of Loan	[1]	Jun. 3, 2016	Jun. 3, 2016
Term of Loan	[1]	Due on demand	Due on demand
Principal Amount Outstanding	[1]	$ 250,000	$ 250,000
Highest Principal Outstanding	[1]	$ 250,000	250,000
Lan T. Tran [Member]
Short-term Debt [Line Items]
Annual Interest Rate	[2]	10.00%
Date of Loan	[2]	Feb. 9, 2017
Term of Loan	[2]	Due on demand
Principal Amount Outstanding	[2]	$ 12,000
Highest Principal Outstanding	[2]	12,000
Notes payable - related party [Member]
Short-term Debt [Line Items]
Principal Amount Outstanding		1,926,850	1,924,850
Highest Principal Outstanding		2,658,615	2,869,648
Amount of Principal Repaid		731,765	944,798
Amount of Interest Paid		$ 4,000	$ 116,336
Yasushi Nagasaki [Member]
Short-term Debt [Line Items]
Annual Interest Rate	[2]	10.00%	10.00%
Date of Loan	[2]	Jun. 29, 2012	Jun. 29, 2012
Term of Loan	[2]	Due on demand	Due on demand
Principal Amount Outstanding	[2]	$ 254,000	$ 254,000
Highest Principal Outstanding	[2]	388,800	388,800
Amount of Principal Repaid	[2]	134,800	134,800
Amount of Interest Paid	[2]	$ 57,886	$ 27,824
Conversion price \| $ / shares	[2]	$ 3.30	$ 3.30
Shares Underlying Principal \| Number	[2]	78,888	94,532
Charles & Kimxa Stark [Member]
Short-term Debt [Line Items]
Annual Interest Rate	[2]	10.00%	10.00%
Date of Loan	[2]	Oct. 1, 2015	Oct. 1, 2015
Term of Loans	[2]	2 years	2 years
Principal Amount Outstanding	[2]	$ 20,000	$ 20,000
Highest Principal Outstanding	[2]	$ 20,000	$ 20,000
Conversion price \| $ / shares	[2]	$ 4.50	$ 4.50
Shares Underlying Principal \| Number	[2]	5,111	5,002
Yutaka & Soomi Niihara [Member]
Short-term Debt [Line Items]
Annual Interest Rate	[2],[3]	10.00%	10.00%
Date of Loan	[2],[3]	Nov. 16, 2015	Nov. 16, 2015
Term of Loans	[2],[3]	2 years	2 years
Principal Amount Outstanding	[2],[3]	$ 200,000	$ 200,000
Highest Principal Outstanding	[2],[3]	$ 200,000	$ 200,000
Conversion price \| $ / shares	[2],[3]	$ 4.50	$ 4.50
Shares Underlying Principal \| Number	[2],[3]	50,557	49,461
Convertible notes payable - related party [Member]
Short-term Debt [Line Items]
Principal Amount Outstanding		$ 474,000	$ 474,000
Highest Principal Outstanding		608,800	608,800
Amount of Principal Repaid		134,800	134,800
Amount of Interest Paid		$ 57,886	$ 27,824
Shares Underlying Principal \| Number		134,556	148,995
Notes payable and convertible notes payable - related party [Member]
Short-term Debt [Line Items]
Principal Amount Outstanding		$ 2,400,850	$ 2,398,850
Highest Principal Outstanding		3,267,415	3,478,448
Amount of Principal Repaid		866,565	1,079,598
Amount of Interest Paid		$ 61,886	$ 144,160
Shares Underlying Principal \| Number		134,556	148,995
Lan T. Tran [Member]
Short-term Debt [Line Items]
Annual Interest Rate	[2]		10.00%
Date of Loan	[2]		Feb. 9, 2015
Term of Loan	[2]		Due on demand
Principal Amount Outstanding	[2]		$ 10,000
Highest Principal Outstanding	[2]		$ 10,000
Hideki & Eiko Uehara [Member]
Short-term Debt [Line Items]
Annual Interest Rate	[4]		11.00%
Date of Loan	[4]		Feb. 15, 2016
Term of Loan	[4]		Due on demand
Highest Principal Outstanding	[4]		$ 133,333
Amount of Principal Repaid	[4]		133,333
Amount of Interest Paid	[4]		$ 12,226
Willis C. Lee [Member]
Short-term Debt [Line Items]
Annual Interest Rate	[2],[3]		10.00%
Date of Loan	[2],[3]		Apr. 8, 2016
Term of Loan	[2],[3]		Due on demand
Highest Principal Outstanding	[2],[3]		$ 79,700
Amount of Principal Repaid	[2],[3]		79,700
Amount of Interest Paid	[2],[3]		$ 1,288

[1]	Dr. Niihara, a director and officer of the Company, is also the Chief Executive Officer of Hope Hospice.
[2]	Officer.
[3]	Director.
[4]	Family of Officer/Director

GEOGRAPHIC INFORMATION (Details

GEOGRAPHIC INFORMATION (Details) - USD ($)	3 Months Ended
GEOGRAPHIC INFORMATION (Details) - USD ($)	Mar. 31, 2017	Mar. 31, 2016
Japan [Member]
Company revenue earned from countries outside of the U.S.
Revenue	$ 28,558	$ 51,074
Percentage of revenue (in percent)	27.00%	64.00%
Taiwan [Member]
Company revenue earned from countries outside of the U.S.
Revenue	$ 64,300	$ 25,211
Percentage of revenue (in percent)	60.00%	32.00%

SUBSEQUENT EVENTS (Details)

SUBSEQUENT EVENTS (Details) - USD ($)	Apr. 01, 2017	Mar. 31, 2017
Principal Amounts		$ 12,701,139
Subsequent Event [Member]
Principal Amounts	$ 6,141,178
Subsequent Event [Member] \| Convertible Notes Payable [Member]
Principal Amounts	$ 4,085,587
Annual Interest Rate	10.00%
Term of Notes	Due on demand ~ 2 Years
Conversion Price	$ 3.50
Subsequent Event [Member] \| Convertible Notes Payable [Member]
Principal Amounts	$ 555,591
Annual Interest Rate	10.00%
Term of Notes	2 years
Conversion Price	$ 3.60
Subsequent Event [Member] \| Promissory Notes Payable [Member]
Principal Amounts	$ 1,500,000
Annual Interest Rate	11.00%
Term of Notes	Due on demand ~ 2 Years

SUBSEQUENT EVENTS (Details 1)

SUBSEQUENT EVENTS (Details 1) - USD ($)	Apr. 01, 2017	Mar. 31, 2017
Common shares		$ 98,800
Subsequent Event [Member]
Common shares	$ 212,800
Number of Shares Issued	28,000