EMI Holding 10-Q 15 May 18 2018 Q1 Quarterly report Financial data

Document and Entity Information

Document and Entity Information - shares	3 Months Ended
	Mar. 31, 2018	May 11, 2018
Document And Entity Information [Abstract]
Entity Registrant Name	EMMAUS LIFE SCIENCES, INC.
Entity Central Index Key	1,420,031
Document Type	10-Q
Trading Symbol	EMMA
Document Period End Date	Mar. 31, 2018
Amendment Flag	false
Current Fiscal Year End Date	--12-31
Entity a Well-known Seasoned Issuer	No
Entity a Voluntary Filer	No
Entity's Reporting Status Current	Yes
Entity Filer Category	Smaller Reporting Company
Entity Common Stock, Shares Outstanding		34,918,822
Document Fiscal Period Focus	Q1
Document Fiscal Year Focus	2,018

CONSOLIDATED BALANCE SHEETS

CONSOLIDATED BALANCE SHEETS - USD ($)	Mar. 31, 2018	Dec. 31, 2017
CURRENT ASSETS
Cash and cash equivalents	$ 5,113,233	$ 15,836,063
Restricted cash		6,720,000
Accounts receivable	684,927	26,814
Inventories, net	1,008,440	625,299
Investment in marketable securities	104,875,712	99,836,397
Marketable securities, pledged to creditor	657,045	160,925
Prepaid expenses and other current assets	226,998	290,371
Total current assets	112,566,355	123,495,869
PROPERTY AND EQUIPMENT, NET	110,502	105,302
OTHER ASSETS
Long-term investment at cost	565,202	65,520
Intangibles, net	63,840	67,200
Deposits	195,818	111,581
Total other assets	824,860	244,301
Total assets	113,501,717	123,845,472
CURRENT LIABILITIES
Accounts payable and accrued expenses	4,979,176	5,695,310
Deferred revenue	595,626
Deferred rent		30,078
Other current liabilities	51,107	10,109
Warrant derivative liabilities	19,491,000	26,377,000
Notes payable, net	4,506,635	7,871,143
Notes payable to related parties, net	2,044,973	2,036,261
Convertible notes payable, net	9,008,600	7,025,002
Convertible notes payable to related parties, net	400,000	400,000
Total current liabilities	41,077,117	49,444,903
LONG-TERM LIABILITIES
Deferred rent		10,821
Other long-term liabilities	41,841,500	36,852,290
Warrant derivative liabilities	1,742,000	1,882,000
Conversion option liabilities		1,289,000
Convertible notes payable, net	17,325,208	20,075,780
Total long-term liabilities	60,908,708	60,109,891
Total liabilities	101,985,825	109,554,794
STOCKHOLDERS’ EQUITY
Preferred stock — par value $0.001 per share, 20,000,000 shares authorized, none issued and outstanding
Common stock — par value $0.001 per share, 100,000,000 shares authorized, 34,910,506 shares and 34,885,506 shares issued and outstanding at March 31, 2018 and December 31, 2017, respectively	34,911	34,886
Additional paid-in capital	117,734,424	113,111,745
Accumulated other comprehensive income (loss)	(72,144)	41,275,785
Treasury stock, at cost — 700,000 shares and 0 shares at March 31, 2018 and December 31, 2017, respectively	(1,314,000)
Accumulated deficit	(104,867,299)	(140,131,738)
Total stockholders’ equity	11,515,892	14,290,678
Total liabilities & stockholders’ equity	$ 113,501,717	$ 123,845,472

CONSOLIDATED BALANCE SHEETS (Pa

CONSOLIDATED BALANCE SHEETS (Parenthetical) - $ / shares	Mar. 31, 2018	Dec. 31, 2017
Statement Of Financial Position [Abstract]
Preferred stock, par value (in dollars per share)	$ 0.001	$ 0.001
Preferred stock, authorized	20,000,000	20,000,000
Preferred stock, issued	0	0
Preferred stock, outstanding	0	0
Common stock, par value (in dollars per share)	$ 0.001	$ 0.001
Common stock, authorized	100,000,000	100,000,000
Common stock, issued	34,910,506	34,885,506
Common stock, outstanding	34,910,506	34,885,506
Treasury stock, shares	700,000	0

CONSOLIDATED STATEMENTS OF COMP

CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS (Unaudited) - USD ($)	3 Months Ended
	Mar. 31, 2018	Mar. 31, 2017
Income Statement [Abstract]
REVENUES, NET	$ 781,314	$ 107,477
COST OF GOODS SOLD	134,679	48,260
GROSS PROFIT	646,635	59,217
OPERATING EXPENSES
Research and development	411,401	755,728
Selling	870,139	101,661
General and administrative	3,806,583	2,799,040
Total operating expenses	5,088,123	3,656,429
LOSS FROM OPERATIONS	(4,441,488)	(3,597,212)
OTHER INCOME (EXPENSE)
Loss on debt extinguishment	(3,244,769)
Change in fair value of warrant derivative liabilities	840,000	(1,228,000)
Change in fair value of embedded conversion option	466,000
Unrealized gain on investment in marketable securities	5,535,435
Interest and other income (loss)	45,552	(13,231)
Interest expense	(5,298,021)	(1,653,891)
Total other expense	(1,655,803)	(2,895,122)
LOSS BEFORE INCOME TAXES	(6,097,291)	(6,492,334)
INCOME TAXES (BENEFIT)		2,400
NET LOSS	(6,097,291)	(6,494,734)
COMPONENTS OF OTHER COMPREHENSIVE INCOME (LOSS)
Unrealized gain on investment in marketable securities		48,970
Unrealized gain (loss) in foreign translation	13,801	(11,607)
Other comprehensive income	13,801	37,363
COMPREHENSIVE LOSS	$ (6,083,490)	$ (6,457,371)
NET LOSS PER COMMON SHARE	$ (0.17)	$ (0.19)
WEIGHTED AVERAGE COMMON SHARES OUTSTANDING	34,891,450	34,706,419

CONSOLIDATED STATEMENT OF CHANG

CONSOLIDATED STATEMENT OF CHANGES IN STOCKHOLDERS' EQUITY (unaudited) - 3 months ended Mar. 31, 2018 - USD ($)	Total	Common Stock [Member]	Additional Paid-In Capital [Member]	Accumulated Other Comprehensive Income (Loss) [Member]	Treasury Stock, at Cost [Member]	Accumulated Deficit [Member]
Balance, beginning at Dec. 31, 2017	$ 14,290,678	$ 34,886	$ 113,111,745	$ 41,275,785		$ (140,131,738)
Balance, beginning (in shares) at Dec. 31, 2017		34,885,506
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Cumulative effect adjustment on adoption of ASU 2016-01				(41,361,730)		41,361,730
Beneficial conversion feature relating to convertible notes	3,637,746		3,637,746
Stock issued for cash	275,000	$ 25	274,975
Stock issued for cash (in shares)		25,000
Repurchase of common stock	(1,314,000)				$ (1,314,000)
Share-based compensation	709,958		709,958
Foreign currency translation effect	13,801			13,801
Net loss	(6,097,291)					(6,097,291)
Balance, ending at Mar. 31, 2018	$ 11,515,892	$ 34,911	$ 117,734,424	$ (72,144)	$ (1,314,000)	$ (104,867,299)
Balance, ending (in shares) at Mar. 31, 2018		34,910,506

CONSOLIDATED STATEMENT OF CHAN6

CONSOLIDATED STATEMENT OF CHANGES IN STOCKHOLDERS' DEFICIT (unaudited) (Parenthetical) - $ / shares	Mar. 31, 2018	Dec. 31, 2017
Statement Of Stockholders Equity [Abstract]
Common stock, par value (in dollars per share)	$ 0.001	$ 0.001
Common stock, authorized	100,000,000	100,000,000

CONSOLIDATED STATEMENTS OF CASH

CONSOLIDATED STATEMENTS OF CASH FLOWS (Unaudited) - USD ($)	3 Months Ended
	Mar. 31, 2018	Mar. 31, 2017
CASH FLOWS FROM OPERATING ACTIVITIES
Net loss	$ (6,097,291)	$ (6,494,734)
Adjustments to reconcile net loss to net cash flows from operating activities
Depreciation and amortization	13,055	5,308
Cost of scrapped inventory written off	7,896
Amortization of discount of convertible notes	4,192,140	1,191,650
Foreign exchange adjustments on convertible notes and notes payable	135,180	103,908
Loss on debt extinguishment	3,244,769
Share-based compensation	709,958	1,028,350
Change in fair value of warrant derivative liabilities	(840,000)	1,228,000
Change in fair value of embedded conversion option	(466,000)
Unrealized gain on investment in marketable securities	(5,535,435)
Net changes in operating assets and liabilities
Accounts receivable	(657,614)	(12,093)
Inventories	(387,605)	(91,970)
Prepaid expenses and other current assets	94,056	51,633
Deposits	(83,500)	3,475
Accounts payable and accrued expenses	(539,266)	937,338
Deferred revenue	595,626
Deferred rent	(40,898)	(4,016)
Other current liabilities	39,790	4,019,339
Other long-term liabilities	5,000,000
Net cash flows provided by (used in) operating activities	(615,139)	1,966,188
CASH FLOWS FROM INVESTING ACTIVITIES
Purchases of property and equipment	(14,712)	(40,424)
Purchase of marketable securities and investment at cost	(469,052)
Net cash flows used in investing activities	(483,764)	(40,424)
CASH FLOWS FROM FINANCING ACTIVITIES
Repurchase of common stock and warrants	(7,500,000)
Proceeds from convertible notes payable issued, net of issuance cost and discount	14,394,700	200,000
Payments of notes payable	(3,500,000)
Payments of convertible notes	(20,000,000)
Proceeds from issuance of common stock	275,000	98,800
Net cash flows provided by (used in) financing activities	(16,330,300)	298,800
Effect of exchange rate changes on cash	(13,627)	2,969
Net increase (decrease) in cash, cash equivalents and restricted cash	(17,442,830)	2,227,533
Cash, cash equivalents and restricted cash, beginning of period	22,556,063	1,317,340
Cash, cash equivalents and restricted cash, end of period	5,113,233	3,544,873
SUPPLEMENTAL DISCLOSURES OF CASH FLOW ACTIVITIES
Interest paid	$ 371,165	69,859
Income taxes paid		$ 2,400

BASIS OF PRESENTATION

BASIS OF PRESENTATION	3 Months Ended
	Mar. 31, 2018
Organization Consolidation And Presentation Of Financial Statements [Abstract]
BASIS OF PRESENTATION	NOTE 1 — BASIS OF PRESENTATION The accompanying unaudited consolidated interim financial statements of Emmaus Life Sciences, Inc. and subsidiaries (collectively, the “Company” or “Emmaus”) have been prepared in accordance with accounting principles generally accepted in the United States of America (“GAAP”) on the basis that the Company will continue as a going concern. The consolidated financial statements include the accounts of the Company and its consolidated subsidiaries. All significant intercompany transactions have been eliminated. The Company’s unaudited consolidated interim financial statements contain adjustments, including normal recurring accruals necessary to present fairly the Company’s consolidated financial position, results of operations, comprehensive income (loss) and cash flows. Due to the uncertainty of the Company’s ability to meet its current operating and capital expenses, there is substantial doubt about the Company’s ability to continue as a going concern, as the continuation and expansion of its business is dependent upon obtaining further financing, successful and sufficient market acceptance of its products, and finally, achieving a profitable level of operations. The consolidated interim financial statements do not include any adjustments that might result from the outcome of these uncertainties. The consolidated interim financial statements should be read in conjunction with the Company’s Annual Report on Form 10-K for the year ended December 31, 2017, filed with the Securities and Exchange Commission (“SEC”) on April 16, 2018 (the “Annual Report”). Interim results for the periods presented herein are not necessarily indicative of the results that may be expected for the fiscal year ending December 31, 2018. The preparation of the consolidated financial statements requires the use of management estimates. Actual results could differ materially from those estimates.

SUMMARY OF SIGNIFICANT ACCOUNTI

SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES	3 Months Ended
	Mar. 31, 2018
Accounting Policies [Abstract]
SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES	NOTE 2 — SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES Refer to the Annual Report for a summary of significant accounting policies. There have been no material changes to the Company’s significant accounting policies during the three months ended March 31, 2018. Below are disclosures of certain interim balances, transactions, and significant assumptions used in computing fair value as of and for the three months ended March 31, 2018 and comparative amounts from the prior fiscal periods: Inventories — All of the raw material purchased during the three months ended March 31, 2018 and for the year ended December 31, 2017 were purchased from one vendor. The below table presents inventory by category: Inventories by category March 31, 2018 December 31, 2017 Raw materials and components $ 106,486 $ — Work-in-process 506,475 124,801 Finished goods 451,281 504,365 Inventory reserve (55,802 ) (3,867 ) Total $ 1,008,440 $ 625,299 Advertising cost — Advertising costs are expensed as incurred. Advertising costs for the three months ended March 31, 2018 and 2017 were $24,401 and $8,391, respectively. Marketable securities — The Company’s marketable securities consist of four securities; (a) 39,250 shares of capital stock of CellSeed, Inc. (“CellSeed”) which are part of 147,100 shares acquired in January 2009 for ¥100,028,000 Japanese Yen (JPY) (equivalent to $1.1 million USD), at ¥680 JPY per share; (b) 849,744 shares of capital stock of KPM Tech Co., Ltd. (“KPM”) which were acquired in October 2016 for ₩14,318,186,400 South Korean Won (KRW) (equivalent to $13 million USD) at ₩16,850 KRW per share; (c) 271,950 shares of capital stock of Hanil Vacuum Co., Ltd. (“Hanil”) which were acquired in October 2016 for ₩1,101,397,500 KRW (equivalent to $1 million USD) at ₩4,050 KRW per share; and (d) 6,643,559 shares of capital stock of Telcon, Inc. (“Telcon”) which were acquired in July 2017 for ₩36,001,446,221 KRW (equivalent to $31.8 million USD) at ₩5,419 KRW per share. As of March 31, 2018 and December 31, 2017, the closing price per share for CellSeed on the Tokyo Stock Exchange was ¥1,780 ($16.74 USD) and ¥462 JPY ($4.10 USD), respectively, the closing price per share for KPM on the Korean Securities Dealers Automated Quotations (“KOSDAQ”) was ₩2,050 ($1.93 USD) and ₩1,625 KRW ($1.52 USD) after 1-for-5 reverse stock split effected on June 28, 2017, respectively, the closing price per share for Hanil on KOSDAQ was ₩2,370 ($2.23 USD) and ₩2,830 KRW ($2.65 USD), respectively, and the closing price per share for Telcon on KOSDAQ was ₩15,350 ($14.46 USD) and ₩14,900 KRW ($13.95 USD), respectively. As of March 31, 2018 and December 31, 2017, 39,250 shares of CellSeed common stock were pledged to secure a $300,000 convertible note of the Company issued to Mitsubishi UFJ Capital III Limited Partnership that is due on demand and were classified as current assets, as marketable securities, pledged to creditor. Prepaid expenses and other current assets — Prepaid expenses and other current assets consisted of the following at March 31, 2018 and December 31, 2017: March 31, December 31, 2018 2017 Prepaid insurance $ 68,391 $ 132,387 Other prepaid expenses and current assets 158,607 157,984 $ 226,998 $ 290,371 Other long-term liabilities —Other long-term liabilities consisted of the following at March 31, 2018 and December 31, 2017: At March 31, 2018 December 31, 2017 Trade discount $ 31,841,500 $ 31,841,500 Unearned revenue 10,000,000 5,000,000 Other long-term liabilities — 10,790 Total other long-term liabilities $ 41,841,500 $ 36,852,290 The Company has entered into an API Supply Agreement (the “API Agreement”) with Telcon pursuant to which Telcon advanced to the Company approximately ₩36.0 billion KRW (approximately $31.8 million USD) as a trade discount to supply 25% of the Company’s requirements for bulk containers of pharmaceutical grade L-glutamine (“PGLG”) for a term of five years, with 10 one-year renewal terms . The agreement will automatically renew unless terminated by either party in writing. The agreement does not include yearly purchase commitments or margin guarantees. The advance trade discount shall be applied against purchases made by the Company from Telcon over the life of the agreement. Fair value measurements — The following table presents the activity for those items measured at fair value on a recurring basis using Level 3 inputs during the three months ended March 31, 2018 and the year ended December 31, 2017: Three months ended Year ended Warrant Derivative Liabilities—Stock Purchase Warrants March 31, 2018 December 31, 2017 Balance, beginning of period $ 26,377,000 $ 10,600,000 Repurchased (6,186,000 ) — Change in fair value included in the statement of comprehensive loss (700,000 ) 15,777,000 Balance, end of period $ 19,491,000 $ 26,377,000 The value of the liability classified warrants, the value of warrant derivative liabilities and the change in fair value of the liability classified warrants and warrant derivative liabilities were determined using a Binomial Monte-Carlo Cliquet (aka “Ratchet”) Option Pricing Model. The model is similar to traditional Black-Scholes-type option pricing models, except that the exercise price resets at certain dates in the future. The values as of March 31, 2018, December 31, 2017 and the initial value as of September 11, 2013 were calculated based on the following assumptions: March 31, 2018 December 31, 2017 December 31, 2016 December 31, 2015 December 31, 2014 December 31, 2013 Initial Value Stock price $ 11.20 $ 11.40 $ 6.00 $ 4.70 $ 4.90 $ 3.60 $ 3.60 Risk‑free interest rate 2.06 % 1.62 % 1.09 % 1.23 % 1.38 % 1.75 % 1.72 % Expected volatility (peer group) 57.10 % 55.80 % 68.30 % 64.10 % 71.50 % 63.20 % 72.40 % Expected life (in years) 0.45 0.70 1.70 2.70 3.70 4.70 5.00 Expected dividend yield — — — — — — — Number outstanding 2,520,501 3,320,501 3,320,501 3,320,501 3,320,501 3,320,501 3,320,501 Balance, end of period: Liability classified warrants $ — $ — $ — $ — $ 3,206,000 $ 6,517,000 $ 7,541,000 Warrant derivative liabilities $ 19,491,000 $ 26,377,000 $ 10,600,000 $ 7,863,000 $ 6,520,000 $ — $ — The following table presents warrants issued in conjunction with Purchase Agreement with GPB measured at fair value as of March 31, 2018: Three months ended March 31, 2018 Year ended December 31, 2017 Liability Instrument—GPB Warrants Embedded Conversion Option Warrants Embedded Conversion Option Balance, beginning of period $ 1,882,000 $ 1,289,000 $ — $ — Fair value at issuance date — — 1,882,000 1,289,000 Change in fair value included in the statement of comprehensive income (loss) (140,000 ) (466,000 ) — — Extinguished upon debt repayment — (823,000 ) — — Balance, end of period $ 1,742,000 $ — $ 1,882,000 $ 1,289,000 Debt and related party debt — The following table presents the effective interest rates on loans originated and refinanced in the respective periods that either had a beneficial conversion feature or an attached warrant: Type of Loan Term of Loan Stated Annual Interest Original Loan Principal Amount Conversion Rate Beneficial Conversion Discount Amount Warrants Issued with Notes Exercise Price Warrant FMV Discount Amount Effective Interest Rate Including Discounts 2017 convertible notes payable Due on demand - 3 years 10% - 13.5% $ 36,113,296 $3.50 - $10.31 $ 11,678,725 240,764 $ 10.80 $ 1,882,000 10% - 110% 2018 convertible notes payable Due on demand - 2 years 10% 16,511,998 $3.50 - $10.00 3,637,746 — — — 22% - 110% $ 52,625,294 $ 15,316,471 240,764 $ 1,882,000 Related party notes are disclosed as separate line items in the Company’s consolidated balance sheets. Net loss per share — As of March 31, 2018 and 2017, respectively, potentially dilutive securities exercisable or convertible into 17,122,176 and 15,554,439 shares of Company common stock were outstanding. No potentially dilutive securities were included in the calculation of diluted loss per share since their effect would be anti-dilutive for all periods presented. Recent accounting pronouncements —In January 2016, the Financial Accounting Standards Board (“FASB”) issued Accounting Standards Update (“ASU”) No. 2016-01, Recognition and Measurement of Financial Assets and Financial Liabilities . The amendments applicable to the Company in this Update (1) supersede the guidance to classify equity securities, except equity method securities, with readily determinable fair values into trading or available-for-sale categories and require equity securities to be measured at fair value with changes in the fair value recognized through net income, (2) allow equity investments that do not have readily determinable fair values to be remeasured at fair value either upon the occurrence of an observable price change or upon identification of an impairment, (3) require assessment for impairment of equity investments without readily determinable fair values qualitatively at each reporting period, (4) eliminate the requirement to disclose the methods and significant assumptions used in calculating the fair value of financial instruments required to be disclosed for financial instruments measured at amortized cost on the balance sheet, (5) require public business entities to use the exit price notion when measuring the fair value of financial instruments for disclosure purposes, (6) require separate presentation of financial assets and financial liabilities by measurement category and form of financial asset (that is, securities or loans and receivables) on the balance sheet or the accompanying notes to the financial statements, (7) clarify that an entity should evaluate the need for a valuation allowance on a deferred tax asset related to available-for-sale securities in combination with the entity’s other deferred tax assets. This Update was effective beginning January 1, 2018 and the Company is now recognizing any changes in the fair value of certain equity investments in net income as prescribed by the new standard rather than in other comprehensive income. We recognized a cumulative effect adjustment to increase the opening balance of retained earnings as of January 1, 2018 by $41.4 million, net of $12.3 million income tax benefit. Refer to Note 4 for additional disclosures required by this ASU. In February 2016, the FASB issued ASU No. 2016-02, Leases In April 2016, the FASB issued ASU 2016-10, Revenue from Contracts with Customers (Topic 606): Identifying Performance Obligations and Licensing In August 2016, the FASB issued ASU No. 2016-15, Statement of Cash Flows (Topic 230), Classification of Certain Cash Receipts and Cash Payments In May 2017, the FASB issued ASU No. 2017-09, Compensation — Stock Compensation (Topic 718): Scope of Modification Accounting In February 2018, the FASB issued ASU No. 2018-02, Income Statement – Reporting Comprehensive Income (Topic 220): Reclassification of Certain Tax Effects from Accumulated Other Comprehensive Income In February 2018, the FASB issued ASU No. 2018-03, Technical Corrections and Improvements to Financial Instruments—Overall (Subtopic 825-10): Recognition and Measurement of Financial Assets and Financial Liabilities Fair Value Measurement Derivatives and Hedging— Embedded Derivatives Financial Instruments— Overall

PROPERTY AND EQUIPMENT

PROPERTY AND EQUIPMENT	3 Months Ended
	Mar. 31, 2018
Property Plant And Equipment [Abstract]
PROPERTY AND EQUIPMENT	NOTE 3 — PROPERTY AND EQUIPMENT Property and equipment consisted of the following at: March 31, 2018 December 31, 2017 Equipment $ 237,449 $ 225,615 Leasehold improvements 64,394 61,054 Furniture and fixtures 74,090 74,090 Sub total 375,933 360,759 Less: accumulated depreciation (265,431 ) (255,457 ) Total $ 110,502 $ 105,302 During the three months ended March 31, 2018 and 2017, depreciation expense was $13,055 and $5,308, respectively.

INVESTMENTS

INVESTMENTS	3 Months Ended
	Mar. 31, 2018
Investments [Abstract]
INVESTMENTS	NOTE 4 — INVESTMENTS Equity Securities— Effective January 1, 2018, we adopted ASU 2016-01 which requires us to measure all equity investments that do not result in consolidation and are not accounted for under the equity method at fair value and recognize any changes in earnings. We use quoted market prices to determine the fair value of equity securities with readily determinable fair values. For equity securities without readily determinable fair values, we have elected the measurement alternative under which we measure these investments at cost minus impairment, if any, plus or minus changes resulting from observable price changes in orderly transactions for the identical or a similar investment of the same issuer. Management assesses each of these investments on an individual basis. Additionally, on a quarterly basis, management is required to make a qualitative assessment of whether the investment is impaired. During the three months ended March 31, 2018, the Company did not recognize any fair value adjustments for equity securities without readily determinable fair values. We recognized a cumulative effect adjustment of $41.4 million, net of $12.3 million income tax benefit, to increase the opening balance of retained earnings with an offset to accumulated other comprehensive income as of January 1, 2018, in connection with the adoption of ASU 2016-01. For fiscal periods beginning prior to January 1, 2018, marketable equity securities not accounted for under the equity method were classified as available-for-sale. There were no marketable equity securities classified as trading. For equity securities classified as available-for-sale, realized gains and losses were included in net loss. Unrealized gains and losses on equity securities classified as available-for-sale were recognized in accumulated other comprehensive income (loss), net of deferred taxes. In addition, the Company had equity securities without readily determinable fair values that were recorded at cost. For these cost method investments, we recorded dividend income, if any, when applicable dividends were declared. Cost method investments were reported as other investments in our consolidated balance sheets, and dividend income from cost method investments was reported in other income (loss) net in our consolidated statements of comprehensive loss. We reviewed all of our cost method investments quarterly to determine if impairment indicators were present; however, we were not required to determine the fair value of these investments unless impairment indicators existed. When impairment indicators did exist, we generally used discounted cash flow analyses to determine the fair value. We estimated that the fair values of our cost method investments approximated their carrying values as of December 31, 2017. Our cost method investments had a carrying value of $65,520 as of December 31, 2017. As of March 31, 2018, the carrying values of our equity securities were included in the following line items in our consolidated balance sheets: At March 31, 2018 Fair Value with Changes Recognized in Income Measurement Alternative - No Readily Determinable Fair Value Marketable securities $ 105,532,757 $ — Other investments — 565,202 Total equity securities $ 105,532,757 $ 565,202 The calculation of net unrealized gains and losses for the period that relate to equity securities still held at March 31, 2018 is as follows: Three Months Ended March 31, 2018 Net gains (losses) recognized during the period related to equity securities $ 5,535,435 Less: Net gains (losses) recognized during the period related to equity securities sold during the period — Unrealized gains (losses) recognized during the period related to equity securities still held at the end of the period $ 5,535,435 As of December 31, 2017, equity securities consisted of the following: Gross Unrealized Estimated Cost Gains Losses Fair Value Trading securities $ — $ — $ — $ — Available-for-sale securities 46,209,017 60,812,231 (6,958,406 ) 100,062,842 Total equity securities $ 46,209,017 $ 60,812,231 $ (6,958,406 ) $ 100,062,842 As of December 31, 2017, the Company had investments classified as available-for-sale in which our cost basis exceeded the fair value of our investment. Management assessed each of the investment in marketable securities that were in a gross unrealized loss position on an individual basis to determine if the decline in fair value was other than temporary. Management's assessment as to the nature of a decline in fair value is based on, among other things, the length of time and the extent to which the market value has been less than our cost basis; the financial condition and near-term prospects of the issuer; and our intent and ability to retain the investment for a period of time sufficient to allow for any anticipated recovery in market value. As a result of these assessments, management determined that the decline in fair value of these investments was not other than temporary and did not record any impairment charges. As of December 31, 2017, the fair values of our equity securities were included in the following line items in our consolidated balance sheets: Trading Securities Available-for-sale securities Marketable securities $ — $ 99,997,322 Long-term investment at cost — 65,520 Total equity securities $ — $ 100,062,842 There were no sale of available-for-sale equity securities during the three months ended March 31, 2018.

ACCOUNTS PAYABLE AND ACCRUED EX

ACCOUNTS PAYABLE AND ACCRUED EXPENSES	3 Months Ended
	Mar. 31, 2018
Payables And Accruals [Abstract]
ACCOUNTS PAYABLE AND ACCRUED EXPENSES	NOTE 5 — ACCOUNTS PAYABLE AND ACCRUED EXPENSES Accounts payable and accrued expenses consisted of the following at: March 31, 2018 December 31, 2017 Accounts payable: Regulatory fees $ — $ 715,999 Clinical and regulatory expenses 174,497 116,736 Commercialization consulting fees 12,321 30,000 Manufacturing cost 122,247 217,155 Legal expenses 68,703 87,701 Consulting fees 523,176 147,038 Accounting fees 86,799 67,293 Selling expenses 341,801 35,383 Investor relations and public relations expenses 36,812 45,526 Board member compensation 75,000 11,200 Other vendors 348,864 125,605 Total accounts payable 1,790,220 1,599,636 Accrued interest payable, related parties 346,901 318,120 Accrued interest payable 2,002,487 1,449,154 Accrued expenses: Wages and payroll taxes payable 118,453 1,711,541 Deferred salary 291,667 291,667 Paid vacation payable 241,071 186,978 Other accrued expenses 188,377 138,214 Total accrued expenses 839,568 2,328,400 Total accounts payable and accrued expenses $ 4,979,176 $ 5,695,310

NOTES PAYABLE

NOTES PAYABLE	3 Months Ended
	Mar. 31, 2018
Debt Disclosure [Abstract]
NOTES PAYABLE	NOTE 6 — NOTES PAYABLE Notes payable consisted of the following at March 31, 2018 and December 31, 2017: Year Issued Interest Rate Range Term of Notes Conversion Price Principal Outstanding March 31, 2018 Discount Amount March 31, 2018 Carrying Amount March 31, 2018 Shares Underlying Notes March 31, 2018 Principal Outstanding December 31, 2017 Discount Amount December 31, 2017 Carrying Amount December 31, 2017 Shares Underlying Notes December 31, 2017 Notes payable 2013 10% Due on demand — $ 940,500 $ — $ 940,500 — $ 887,600 $ — $ 887,600 — 2015 10% Due on demand — 10,000 — 10,000 — — — — — 2016 10% - 11% Due on demand — 843,335 — 843,335 — 833,335 — 833,335 — 2017 11% Due on demand — 2,712,800 — 2,712,800 — 6,150,208 — 6,150,208 — $ 4,506,635 $ — $ 4,506,635 — $ 7,871,143 $ — $ 7,871,143 — Current $ 4,506,635 $ — $ 4,506,635 — $ 7,871,143 $ — $ 7,871,143 — Non-current $ — $ — $ — — $ — $ — $ — — Notes payable - related party 2015 11% Due on demand — 300,000 — 300,000 — 310,000 — 310,000 — 2016 10% - 11% Due on demand — 670,000 — 670,000 — 810,510 — 810,510 — 2017 10% Due on demand — 915,751 — 915,751 — 915,751 — 915,751 — 2018 11% Due on demand — 159,222 — 159,222 — — — — — $ 2,044,973 $ — $ 2,044,973 — $ 2,036,261 $ — $ 2,036,261 — Current $ 2,044,973 $ — $ 2,044,973 — $ 2,036,261 $ — $ 2,036,261 — Non-current $ — $ — $ — — $ — $ — $ — — Convertible notes payable 2011 10% 5 years $ 3.05 $ 300,000 $ — $ 300,000 98,285 $ 300,000 $ — $ 300,000 98,285 2014 10% Due on demand - 2 years $3.05 - $3.60 512,600 — 512,600 178,285 486,878 — 486,878 168,766 2016 10% Due on demand - 2 years $3.50 - $4.50 922,829 38,957 883,872 265,463 1,516,329 83,298 1,433,031 441,048 2017 10% Due on demand - 2 years $3.50 - $10.00 15,202,887 3,587,673 11,615,214 3,219,371 36,113,296 11,232,423 24,880,873 5,357,488 2018 10% Due on demand - 2 years $3.50 - $10.00 16,511,998 3,489,876 13,022,122 1,965,523 — $ 33,450,314 $ 7,116,506 $ 26,333,808 5,726,927 $ 38,416,503 $ 11,315,721 $ 27,100,782 6,065,587 Current $ 12,550,522 $ 3,541,922 $ 9,008,600 3,393,245 $ 12,860,912 $ 5,835,910 $ 7,025,002 3,449,984 Non-current $ 20,899,792 $ 3,574,584 $ 17,325,208 2,615,603 $ 25,555,591 $ 5,479,811 $ 20,075,780 2,615,603 Convertible notes payable - related party 2012 10% Due on demand $ 3.30 $ 200,000 $ — $ 200,000 69,616 $ 200,000 $ — $ 200,000 68,122 2015 10% 2 years $ 4.50 200,000 — 200,000 55,001 200,000 — 200,000 53,905 $ 400,000 $ — $ 400,000 124,617 $ 400,000 $ — $ 400,000 122,027 Current $ 400,000 $ — $ 400,000 122,027 $ 400,000 $ — $ 400,000 122,027 Non-current $ — $ — $ — — $ — $ — $ — — Grand Total $ 40,401,922 $ 7,116,506 $ 33,285,416 5,851,544 $ 48,723,907 $ 11,315,721 $ 37,408,186 6,187,614 The weighted average stated interest rate of notes payable as of March 31, 2018 and December 31, 2017 was 10% and 11%, respectively. The weighted average effective interest rates of notes payable for the three-month period ended March 31, 2018 and the year ended December 31, 2017 were 37% and 24% respectively, after giving effect to discounts relating to beneficial conversion features and the fair value of warrants issued in connection with these notes. The notes payable and convertible notes payable do not have restrictive financial covenants or acceleration clauses associated with a material adverse change event. The holders of the convertible notes have the option to convert their notes into Company common stock at the stated conversion price during the term of their convertible notes. Conversion prices on these convertible notes payable range from $3.05 to $10.00 per share. Certain notes with a $4.50 or a $10.00 stated conversion price in the second year of their two-year term are subject to automatic conversion into shares of Company common stock at a conversion price equal to 80% of the initial public offering price at the time of a qualified public offering. All notes due on demand are treated as current liabilities. Contractual principal payments due on notes payable are as follows: Year Ending Amount 2018 $ 19,174,057 2019 5,883,665 2020 15,344,200 Total $ 40,401,922 The Company estimated the total fair value of any beneficial conversion feature and accompanying warrants in allocating the note proceeds. The proceeds allocated to the beneficial conversion feature were determined by taking the estimated fair value of shares issuable under the convertible notes less the fair value of the number of shares that would be issued if the conversion rate equaled the fair value of Company common stock as of the date of issuance (see Note 2). The fair value of the warrants issued in conjunction with notes was determined using the Black Scholes Merton Option Pricing Model with the following inputs for the periods ended December 31, 2017. The Company did not issue any warrants in conjunction with notes in the three months ended March 31, 2018. 2018 2017 Stock price — $ 11.40 Exercise price — $ 10.80 Term — 5 years Risk‑free interest rate — 2.20 % Expected dividend yield — — Expected volatility — 70.0 % In situations where the notes included both a beneficial conversion feature and a warrant, the proceeds were allocated to the warrants and beneficial conversion feature based on their respective pro rata fair values.

STOCKHOLDERS' DEFICIT

STOCKHOLDERS' DEFICIT	3 Months Ended
	Mar. 31, 2018
Stockholders Equity Note [Abstract]
STOCKHOLDERS' DEFICIT	NOTE 7 — STOCKHOLDERS’ DEFICIT Private placement — On September 11, 2013, the Company issued an aggregate of 3,020,501 units at a price of $2.50 per unit (the “Private Placement”). Each unit consisted of one share of common stock and one common stock warrant for the purchase of an additional share of common stock. The aggregate purchase price for the units was $7,551,253. In addition, 300,000 warrants for the purchase of a share of common stock were issued to a broker under the same terms as the Private Placement transaction (the “Broker Warrants”). The warrants issued in the Private Placement and the Broker Warrants entitle the holders thereof to purchase, at any time on or prior to September 11, 2018, shares of common stock of the Company at an exercise price of $3.50 per share. The warrants contain non-standard anti-dilution protection and, consequently, are being accounted for as liabilities, were originally recorded at fair value, and are adjusted to fair market value each reporting period. Because the shares of common stock underlying the Private Placement warrants and Broker Warrants were not effectively registered for resale by September 11, 2014, the warrant holders have an option to exercise the warrants using a cashless exercise feature. The shares have not been registered for resale as of March 31, 2018. The availability to warrant holders of the cashless exercise feature as of September 11, 2014 caused the then-outstanding 2,225,036 Private Placement warrants and Broker Warrants with fair value of $7,068,000 to be reclassified from liability classified warrants to warrant derivative liabilities and to continue to be remeasured at fair value each reporting period. On June 10, 2014, certain warrant holders exercised 1,095,465 warrants issued in the Private Placement for the exercise price of $3.50 per share, resulting in the Company receiving aggregate exercise proceeds of $3.8 million and issuing 1,095,465 shares of common stock. Prior to exercise, these Private Placement warrants were accounted for at fair value as liability classified warrants. As of June 10, 2014, immediately prior to exercise, the carrying value of these Private Placement warrants was reduced to their fair value immediately prior to exercise of $1.8 million, representing their intrinsic value, with this adjusted carrying value of $1.8 million being transferred to additional paid-in capital. Also on June 10, 2014, based on an offer made to holders of Private Placement warrants in connection with such exercises, the Company issued an aggregate of 1,095,465 replacement warrants to holders exercising Private Placement warrants, which replacement warrants have terms that are generally the same as the exercised warrants, including an expiration date of September 11, 2018 and an exercise price of $3.50 per share. The replacement warrants are treated for accounting purposes as liability classified warrants, and their issuance gave rise to a $3.5 million warrant exercise inducement expense based on their fair value as of issuance as determined using a Binomial Monte-Carlo Cliquet (aka Ratchet) Option Pricing Model. Because the shares of common stock underlying the replacement warrants were not effectively registered for resale by June 10, 2015, the warrant holders have an option to exercise the warrants using a cashless exercise feature. The shares have not been registered for resale as of March 31, 2018. The availability to warrant holders of the cashless exercise feature as of June 10, 2015 caused the then-outstanding 1,095,465 replacement warrants with fair value of $2,545,000 to be reclassified from liability classified warrants to warrant derivative liabilities and to continue to be remeasured at fair value each reporting period. As of March 31, 2018, the aggregate fair value of the Private Placement warrants, replacement warrants and the Broker Warrants was $19,491,000 (see Note 2). For further details regarding registration rights associated with the Private Placement warrants, replacement warrants and Broker Warrants, see the Registration Rights section below in this footnote. A summary of outstanding warrants as of March 31, 2018 and December 31, 2017 is presented below: Three months ended Year ended March 31, 2018 December 31, 2017 Warrants outstanding, beginning of period 5,265,432 5,024,668 Granted — 240,764 Exercised — — Cancelled, forfeited and expired (800,000 ) — Warrants outstanding, end of period 4,465,432 5,265,432 A summary of outstanding warrants by year issued and exercise price as of March 31, 2018 is presented below: Outstanding Exercisable Year issued and Exercise Price Number of Warrants Issued Weighted Average Remaining Contractual Life (Years) Weighted Average Exercise Price Total Weighted Average Exercise Price At December 31, 2013 $ 3.30 50,000 0.08 $ 3.30 50,000 $ 3.30 $ 3.50 1,822,693 0.45 $ 3.50 1,822,693 $ 3.50 2013 total 1,872,693 1,872,693 At December 31, 2014 $ 3.50 747,808 0.49 $ 3.50 747,808 $ 3.50 2014 Total 747,808 747,808 At December 31, 2015 $ 4.90 110,417 1.93 $ 4.90 110,417 $ 4.90 2015 Total 110,417 110,417 $ 4.50 118,750 3.25 $ 4.50 118,750 $ 4.50 $ 4.70 75,000 3.09 $ 4.70 75,000 $ 4.70 $ 5.00 1,300,000 3.11 $ 5.00 1,300,000 $ 5.00 2016 Total 1,493,750 1,493,750 At December 31, 2017 $ 10.80 240,764 5.25 $ 10.80 240,764 $ 10.80 At March 31, 2018 Total 4,465,432 4,465,432 Stock options — During the three months ended March 31, 2018, the Company granted 30,000 options to its directors. During the year ended December 31, 2017, 50,000 options were granted by the Company’s Board of Directors to a consultant. These options vested immediately, have an exercise price of $11.40 per share and are exercisable through 2027. As of March 31, 2018, there were 6,805,200 options outstanding under the Company’s 2011 Stock Incentive Plan. Summaries of outstanding options as of March 31, 2018 and December 31, 2017 are presented below. March 31, 2018 December 31, 2017 Number of Options Weighted‑ Average Exercise Price Number of Options Weighted‑ Average Exercise Price Options outstanding, beginning of period 6,775,200 $ 4.12 6,955,200 $ 4.10 Granted or deemed issued 30,000 $ 11.40 50,000 $ 11.40 Exercised — $ — (11,895 ) $ 4.19 Cancelled, forfeited and expired — $ — (218,105 ) $ 4.98 Options outstanding, end of period 6,805,200 $ 4.15 6,775,200 $ 4.12 Options exercisable at end of year 5,840,456 $ 3.99 5,604,439 $ 3.95 Options available for future grant 2,194,800 2,224,800 During the three months ended March 31, 2018 and 2017, the Company recognized $0.7 million and $1.0 million, respectively, of share-based compensation expense arising from stock options. As of March 31, 2018, there was $6.8 million of total unrecognized compensation expense related to unvested share-based compensation arrangements granted under the Company’s 2011 Stock Incentive Plan. That expense is expected to be recognized over the weighted-average remaining period of 1.2 years. Registration rights — Pursuant to the Purchase Warrant relating to the GPB Debt Holdings II, LLC issued by the Company on December 29, 2017, the Company entered into a Registration Rights Agreement (the “Registration Rights Agreement”) pursuant to which the Company has agreed to file a registration statement with the Securities and Exchange Commission (the “Commission”) relating to the offer and sale by GPB of the Company Shares underlying the Warrants. The Company is required to file a registration statement within one hundred eighty (180) days of closing of a public listing of the Company’s Common Stock for trading on any national securities exchange (excluding any over-the-counter market), whether through a direct listing application or merger transaction. The Company is required to have the registration statement become effective on the earlier of (A) the date that is two-hundred and forty (240) days following the later to occur of (i) the date of closing of the public listing or (ii) or in the event the registration statement receives a “full review” by the Commission, the date that is 300 days following the date of closing of the public listing, or (B) the date which is within three (3) business days after the date on which the Commission informs the Company (i) that the Commission will not review the registration statement or (ii) that the Company may request the acceleration of the effectiveness of the registration statement. If the Company does not effect such registration within that period of time, it will be required to pay GPB for liquidated damages an amount of cash equal to 2% of the product of (i) the number of Registrable Securities and (ii) the Closing Sale Price or Closing Bid Price as of the trading day immediately prior to the Event Date, such payments to be made on the Event Date and every thirty (30) day anniversary thereafter with a maximum penalty of 12% until the applicable Event is cured; provided, however, that in the event the Commission does not permit all of the Registrable Securities to be included in the Registration Statement because of its application of Rule 415, liquidated damages shall only be payable by the Company based on the portion of the Holder’s initial investment in the Securities that corresponds to the number of such Holder’s Registrable Securities permitted to be registered by the Commission in such Registration Statement pursuant to Rule 415. Pursuant to the Subscription Agreements relating to the Private Placement and certain warrants, as well as the replacement warrants issued by the Company on June 10, 2014, the Company agreed to use its commercially reasonable best efforts to have on file with the SEC, by September 11, 2014 and at the Company’s sole expense, a registration statement to permit the public resale of 4,115,966 shares of Company common stock and 3,320,501 shares of common stock underlying warrants (collectively, the “Registrable Securities”). In the event such registration statement includes securities to be offered and sold by the Company in a fully underwritten primary public offering pursuant to an effective registration under the Securities Act of 1933, as amended (the “Securities Act”), and the Company is advised in good faith by any managing underwriter of securities being offered pursuant to such registration statement that the number of Registrable Securities proposed to be sold in such offering is greater than the number of such securities which can be included in such offering without materially adversely affecting such offering, the Company will include in such registration the following securities in the following order of priority: (i) any securities the Company proposes to sell, and (ii) the Registrable Securities, with any reductions in the number of Registrable Securities actually included in such registration to be allocated on a pro rata basis among the holders thereof. The registration rights described above apply until all Registrable Securities have been sold pursuant to Rule 144 under the Securities Act or may be sold without registration in reliance on Rule 144 under the Securities Act without limitation as to volume and without the requirement of any notice filing. If the shares of common stock underlying these warrants to purchase 3,320,501 shares are not registered for resale at the time of exercise, and the registration rights described above then apply with respect to the holder of such warrants, such holder may exercise such warrants on a cashless basis. In such a cashless exercise of all the shares covered by the warrant, the warrant holder would receive a number of shares equal to the quotient of (i) the difference between the fair market value of the common stock, as defined, and the $3.50 exercise price, as adjusted, multiplied by the number of shares exercisable under the warrant, divided by (ii) the fair market value of the common stock, as defined. As of March 31, 2018, based on a fair market value of a share of Company common stock of $11.20 and 2,520,501 warrants issued and outstanding and eligible for cashless exercise after cancellation of 800,000 of such warrants as of March 29, 2018, the maximum number of shares the Company would be required to issue, if the warrant holders elected to exercise the cashless exercise feature with respect to all then eligible warrants, is 1,732,844 shares. If the fair market value of a share of Company common stock were to increase by $1.00 from $11.20 to $12.20, the maximum number of shares the Company would be required to issue, if the warrant holders elected to exercise the cashless exercise feature with respect to all then eligible warrants, would increase to 1,797,406 shares as of March 31, 2018. The Company has not yet filed a registration statement with respect to the resale of the Registrable Securities. The Company believes that it has used commercially reasonable efforts to file a registration statement with respect to the resale of Registrable Securities. Korean Private Placement — On September 12, 2016, the Company entered into Letter of Agreement with KPM and Hanil, both Korean-based public companies whose shares are listed on KOSDAQ, a trading board of Korea Exchange in South Korea. In the Letter of Agreement, the parties agreed that KPM and Hanil would purchase by September 30, 2016 $17 million and $3 million, respectively, of shares of the Company’s common stock at a price of $4.50 per share. In exchange, the Company agreed to invest $13 million and $1 million in future capital increases by KPM and Hanil, respectively, at prices based upon the trading prices of KPM and Hanil shares on KOSDAQ. In connection with the Letter of Agreement, KPM and Hanil entered into the Company’s standard form subscription agreement with respect to their purchase of shares which contains customary representations and warranties of the parties. On September 29, 2016, KPM and Hanil purchased from the Company 3,777,778 shares and 666,667 shares, respectively, of common stock at a price of $4.50 a share for $17 million and $3 million, respectively, or a total of $20 million. The Company recognized $720,000 as a reduction to its additional paid-in-capital for fees and commissions payable by the Company in connection with the transaction. Pursuant to the terms of the Letter of Agreement dated September 12, 2016, the Company invested $13 million and $1 million in capital increases by KPM and Hanil, respectively, at $15.32 and $3.68, respectively, per capital share. Pursuant to the terms of a subscription agreement dated as of September 11, 2013 among the Company and certain purchasers of shares of the Company’s common stock and warrants to purchase shares of our common stock, the purchasers are entitled to participation rights with respect to the sale of shares or placement of debt. To the extent the purchasers exercise their participation rights, the Company may be obliged to sell to them a specified number of shares of our common stock at the price per share and other terms set forth in the Letter of Agreement. There can be no assurance that any purchaser will exercise its participation rights or that any shares of the Company’s common stock will be issued to any purchaser.

COMMITMENTS AND CONTINGENCIES

COMMITMENTS AND CONTINGENCIES	3 Months Ended
	Mar. 31, 2018
Commitments And Contingencies Disclosure [Abstract]
COMMITMENTS AND CONTINGENCIES	NOTE 8 — COMMITMENTS AND CONTINGENCIES Distribution contract —The Company selected AmerisourceBergen for its integrated commercialization solution to support Endari sales, US Bioservices as the Specialty Pharmacy, ASD Healthcare for Specialty Distribution and ICS for Third-Party Logistics. Cardinal Health Specialty Pharmacy Services has been contracted to distribute NutreStore to other wholesale distributors and some independent pharmacies since April 2008. On August 29, 2017, the Company signed a distributor agreement, effective as of August 23, 2017, with Megapharm Ltd., an Israeli Corporation (“Megapharm”), under which the Company granted Megapharm the exclusive rights to distribute Endari™ (L-glutamine oral powder) in Israel and in the Palestinian Authority, or the territories. The term of the distributor agreement is for seven years from the product registration approval in the territories, unless earlier terminated as provided therein, and will renew automatically for successive one-year terms unless terminated by either party by written notice to the other party no less than 60 days prior to the date the term would renew. In the distributor agreement, Megapharm agrees to use its reasonable best efforts to actively and diligently promote the sale of Endari in the territories and to maintain a competent and experienced sales force to serve each of the territories. Megapharm also agrees in the distributor agreement to purchase from the Company specified annual minimum quantities of Endari during each of the first five years of the term. The distributor agreement contains customary representations and warranties of the parties and customary mutual indemnification provisions. Operating leases — The Company leases its office space under operating leases with unrelated entities. The Company has opened its New York office in February 2018 to support a sales team focused on commercial sales for Endari. The rent expense during the three months ended March 31, 2018 and 2017 amounted to $124,286 and $151,312, respectively. Future minimum lease payments under the agreements are as follows as of March 31, 2018: Year Amount 2018 (nine months) $ 238,673 2019 687,032 2020 611,012 2021 626,545 2022 646,047 Thereafter 777,344 Total $ 3,586,653 Management Control Acquisition Agreement — As previously reported in its Form 8-K filed on June 19, 2017 and Form 10-Q filed on August 17, 2017, that on June 12, 2017, the Company entered into a Management Control Acquisition Agreement (the “MCAA”) with Telcon Holdings, Inc. (“Telcon Holdings”), a Korean corporation, and Telcon (“Telcon”), a Korean-based public company whose shares are listed on KOSDAQ, a trading board of Korea Exchange in South Korea. In accordance with the MCAA, the Company invested ₩36.0 billion KRW (approximately $31.8 million USD) to purchase 6,643,559 shares of Telcon’s common stock shares at a purchase price of ₩5,419 KRW (approximately $4.79 USD) per share. Upon consummation of the MCAA, the Company became Telcon’s largest shareholder owning approximately 10.3% of Telcon’s outstanding common stock shares and received representation on its board of directors. Subsequent to entering into the MCAA, the Company held discussions with Telcon Holdings and Telcon to re-negotiate and clarify certain of the terms in the MCAA. On September 29, 2017, the Company executed a revised agreement with Telcon Holdings and Telcon which called for the Company’s representatives on Telcon’s board of directors to resign effective as of September 29, 2017 and granted the voting rights of the Company’s shares of Telcon’s common stock to Telcon Holdings to change the composition of the board of directors of Telcon. In addition, the revised agreement contains a provision for Telcon Holdings or any persons designated by Telcon Holdings to lend to the Company a bridge loan for $3.5 million. The Company has repaid the loan in full along with any interest accrued at 5% per annum immediately upon receipt of the $10 million due by December 31, 2017 under the distribution agreements for diverticulosis treatment for the geographical regions of Korea, Japan, China, and Australia. The loan was collateralized by a $5 million security interest in the amount due to the Company for the aforementioned distribution agreements as well as by shares of Telcon and KPM held by the Company pledged as additional security interest for the loan. API Supply Agreement — The Company had previously reported in its Form 8-K filed on June 19, 2017, that on June 12, 2017, the Company entered into an API Supply Agreement (the “API Agreement”) with Telcon pursuant to which Telcon paid the Company approximately ₩36 billion KRW (approximately $31.8 million USD) in consideration of the right to supply 25% of the Company’s requirements for bulk containers of PGLG for a fifteen-year term. Due to unforeseen circumstances, the Company and Telcon held new discussions to re-negotiate certain terms of the API Agreement. The Company and Telcon made significant changes to critical terms of the API Agreement, which resulted in the Company and Telcon signing a Raw Material Supply Agreement (“Revised API Agreement”) on July 12, 2017. The Revised API Agreement is effective for a term of five years with 10 one-year renewal periods for a maximum of 15 years and the agreement will automatically renew unless terminated by either party in writing. The Revised API Agreement does not include yearly purchase commitments or margin guarantees, but revises the API Agreement such that a unit price is established for 940,000 kilograms of PGLG at $50 USD per kilogram for a total of $47 million over the 15 years. The Revised API Supply Agreement is silent on yearly purchase commitments and margin guarantees on purchases of $5 million and $2.5 million, respectively.

RELATED PARTY TRANSACTIONS

RELATED PARTY TRANSACTIONS	3 Months Ended
	Mar. 31, 2018
Related Party Transactions [Abstract]
RELATED PARTY TRANSACTIONS	NOTE 9 — RELATED PARTY TRANSACTIONS The following table sets forth information relating to our loans from related persons outstanding as of the date hereof or at any time during the three months ended March 31, 2018. Class Lender Interest Rate Date of Loan Term of Loan Principal Amount Outstanding at March 31, 2018 Highest Principal Outstanding Amount of Principal Repaid or Converted into Stock Amount of Interest Paid Conversion Rate Shares Underlying Notes March 31, 2018 Current, Promissory note payable to related parties: Masaharu & Emiko Osato (3) 11% 12/29/2015 Due on Demand 300,000 300,000 — — — — Masaharu & Emiko Osato (3) 11% 2/25/2016 Due on Demand 400,000 400,000 — — — — Lan T. Tran (2) 10% 4/29/2016 Due on Demand 20,000 20,000 — — — — Hope Hospice (1) 10% 6/3/2016 Due on Demand 250,000 250,000 — — — — Lan T. Tran (2) 10% 2/9/2017 Due on Demand 12,000 12,000 — — — — Yutaka Niihara (2)(3) 10% 9/14/2017 Due on Demand 903,751 903,751 — — — — Lan T. Tran (2) 10% 2/10/2018 Due on Demand 159,222 159,222 — — — — Subtotal $ 2,044,973 $ 3,571,078 $ 794,339 $ 129,470 Current, Convertible notes payable to related parties: Yasushi Nagasaki (2) 10% 6/29/2012 Due on Demand $ 200,000 $ 388,800 $ 188,800 $ 57,886 $ 3.30 69,616 Yutaka & Soomi Niihara (2)(3) 10% 11/16/2015 2 years 200,000 200,000 — — $ 4.50 55,001 Subtotal $ 400,000 $ 608,800 $ 208,800 $ 62,291 124,617 Total $ 2,444,973 $ 4,179,878 $ 1,003,139 $ 191,761 124,617 (1) Dr. Niihara, a director and officer of the Company, is also the Chief Executive Officer of Hope Hospice. (2) Officer. (3) Director. (4) Family of Officer/Director. The following table sets forth information relating to our loans from related persons outstanding as of the date hereof or at any time during the year ended December 31, 2017. Class Lender Interest Rate Date of Loan Term of Loan Principal Amount Outstanding at December 31, 2017 Highest Principal Outstanding Amount of Principal Repaid or Converted into Stock Amount of Interest Paid Conversion Rate Shares Underlying Notes December 31, 2017 Current, Promissory note payable to related parties: Hope Hospice (1) 8% 1/17/2012 Due on Demand $ — $ 200,000 $ 200,000 $ 7,331 — — Hope Hospice (1) 8% 6/14/2012 Due on Demand — 200,000 200,000 14,762 — — Hope Hospice (1) 8% 6/21/2012 Due on Demand — 100,000 100,000 7,249 — — Hope Hospice (1) 8% 2/11/2013 Due on Demand — 50,000 50,000 1,559 — — Hope Hospice (1) 10% 1/7/2015 Due on Demand — 100,000 100,000 28,630 — — IRA Service Trust Co. FBO Peter B. Ludlum (2) 10% 2/20/2015 Due on Demand 10,000 10,000 — — — — Masaharu & Emiko Osato (3) 11% 12/29/2015 Due on Demand 300,000 300,000 — — — — Yutaka Niihara (2)(3) 10% 5/21/2015 Due on Demand — 826,105 94,339 61,829 — — Lan T. Tran (2) 11% 2/10/2016 Due on Demand 130,510 130,510 — — — — Masaharu & Emiko Osato (3) 11% 2/25/2016 Due on Demand 400,000 400,000 — — — — Hope Hospice (1) 10% 4/4/2016 Due on Demand — 50,000 50,000 8,110 — — Lan T. Tran (2) 10% 4/29/2016 Due on Demand 20,000 20,000 — — — — IRA Service Trust Co. FBO Peter B. Ludlum (2) 10% 5/5/2016 Due on Demand 10,000 10,000 — — — — Hope Hospice (1) 10% 6/3/2016 Due on Demand 250,000 250,000 — — — — Lan T. Tran (2) 10% 2/9/2017 Due on Demand 12,000 12,000 — — — — Yutaka Niihara (2)(3) 10% 9/14/2017 Due on Demand 903,751 903,751 — — — — Subtotal $ 2,036,261 $ 3,562,366 $ 794,339 $ 129,470 — Current, Convertible notes payable to related parties: Yasushi Nagasaki (2) 10% 6/29/2012 Due on Demand $ 200,000 $ 388,800 $ 188,800 $ 57,886 $ 3.30 68,122 Charles & Kimxa Stark (2) 10% 10/1/2015 2 years — 20,000 20,000 4,405 $ 4.50 — Yutaka & Soomi Niihara (2)(3) 10% 11/16/2015 2 years 200,000 200,000 — — $ 4.50 53,905 Subtotal $ 400,000 $ 608,800 $ 208,800 $ 62,291 122,027 Total $ 2,436,261 $ 4,171,166 $ 1,003,139 $ 191,761 122,027 (1) Dr. Niihara, a director and officer of the Company, is also the Chief Executive Officer of Hope Hospice. (2) Officer (3) Director (4) Family of Officer/Director

GEOGRAPHIC INFORMATION

GEOGRAPHIC INFORMATION	3 Months Ended
	Mar. 31, 2018
Segment Reporting [Abstract]
GEOGRAPHIC INFORMATION	NOTE 10 — GEOGRAPHIC INFORMATION For the three months ended March 31, 2018 and 2017, the Company earned revenue from countries as outlined in the table below: Country Revenue for the three months ended March 31, 2018 % of total revenue for the three months ended March 31, 2018 Revenue for the three months ended March 31, 2017 % of total revenue for the three months ended March 31, 2017 United States $ 675,046 86 % $ 14,619 13 % Japan 43,005 6 % 28,558 27 % Taiwan 26,100 3 % 64,300 60 % France 37,162 5 % — — % The Company did not have any significant currency translation or foreign transaction adjustments during the three months ended March 31, 2018 or 2017.

SUBSEQUENT EVENTS

SUBSEQUENT EVENTS	3 Months Ended
	Mar. 31, 2018
Subsequent Events [Abstract]
SUBSEQUENT EVENTS	NOTE 11 — SUBSEQUENT EVENTS Subsequent to March 31, 2018, the Company issued the following: Notes Issued after March 31, 2018 Principal Amounts Annual Interest Rate Term of Notes Conversion Price Convertible note $ 250,000 10% 2 Years $ 10.00 Subsequent to March 31, 2018, the Company issued the following shares upon cashless exercise by a warrant holder: Common Shares Issued after March 31, 2018 Amounts Number of Shares Issued Common shares $ — 8,316

SUMMARY OF SIGNIFICANT ACCOUN19

SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Policies)	3 Months Ended
	Mar. 31, 2018
Accounting Policies [Abstract]
Inventories	Inventories — All of the raw material purchased during the three months ended March 31, 2018 and for the year ended December 31, 2017 were purchased from one vendor. The below table presents inventory by category: Inventories by category March 31, 2018 December 31, 2017 Raw materials and components $ 106,486 $ — Work-in-process 506,475 124,801 Finished goods 451,281 504,365 Inventory reserve (55,802 ) (3,867 ) Total $ 1,008,440 $ 625,299
Advertising cost	Advertising cost — Advertising costs are expensed as incurred. Advertising costs for the three months ended March 31, 2018 and 2017 were $24,401 and $8,391, respectively.
Marketable securities	Marketable securities — The Company’s marketable securities consist of four securities; (a) 39,250 shares of capital stock of CellSeed, Inc. (“CellSeed”) which are part of 147,100 shares acquired in January 2009 for ¥100,028,000 Japanese Yen (JPY) (equivalent to $1.1 million USD), at ¥680 JPY per share; (b) 849,744 shares of capital stock of KPM Tech Co., Ltd. (“KPM”) which were acquired in October 2016 for ₩14,318,186,400 South Korean Won (KRW) (equivalent to $13 million USD) at ₩16,850 KRW per share; (c) 271,950 shares of capital stock of Hanil Vacuum Co., Ltd. (“Hanil”) which were acquired in October 2016 for ₩1,101,397,500 KRW (equivalent to $1 million USD) at ₩4,050 KRW per share; and (d) 6,643,559 shares of capital stock of Telcon, Inc. (“Telcon”) which were acquired in July 2017 for ₩36,001,446,221 KRW (equivalent to $31.8 million USD) at ₩5,419 KRW per share. As of March 31, 2018 and December 31, 2017, the closing price per share for CellSeed on the Tokyo Stock Exchange was ¥1,780 ($16.74 USD) and ¥462 JPY ($4.10 USD), respectively, the closing price per share for KPM on the Korean Securities Dealers Automated Quotations (“KOSDAQ”) was ₩2,050 ($1.93 USD) and ₩1,625 KRW ($1.52 USD) after 1-for-5 reverse stock split effected on June 28, 2017, respectively, the closing price per share for Hanil on KOSDAQ was ₩2,370 ($2.23 USD) and ₩2,830 KRW ($2.65 USD), respectively, and the closing price per share for Telcon on KOSDAQ was ₩15,350 ($14.46 USD) and ₩14,900 KRW ($13.95 USD), respectively. As of March 31, 2018 and December 31, 2017, 39,250 shares of CellSeed common stock were pledged to secure a $300,000 convertible note of the Company issued to Mitsubishi UFJ Capital III Limited Partnership that is due on demand and were classified as current assets, as marketable securities, pledged to creditor.
Prepaid expenses and other current assets	Prepaid expenses and other current assets — Prepaid expenses and other current assets consisted of the following at March 31, 2018 and December 31, 2017: March 31, December 31, 2018 2017 Prepaid insurance $ 68,391 $ 132,387 Other prepaid expenses and current assets 158,607 157,984 $ 226,998 $ 290,371
Other Non-Current Liabilities	Other long-term liabilities — Other long-term liabilities consisted of the following at March 31, 2018 and December 31, 2017: At March 31, 2018 December 31, 2017 Trade discount $ 31,841,500 $ 31,841,500 Unearned revenue 10,000,000 5,000,000 Other long-term liabilities — 10,790 Total other long-term liabilities $ 41,841,500 $ 36,852,290 The Company has entered into an API Supply Agreement (the “API Agreement”) with Telcon pursuant to which Telcon advanced to the Company approximately ₩36.0 billion KRW (approximately $31.8 million USD) as a trade discount to supply 25% of the Company’s requirements for bulk containers of pharmaceutical grade L-glutamine (“PGLG”) for a term of five years, with 10 one-year renewal terms . The agreement will automatically renew unless terminated by either party in writing. The agreement does not include yearly purchase commitments or margin guarantees. The advance trade discount shall be applied against purchases made by the Company from Telcon over the life of the agreement.
Fair value measurements	Fair value measurements — The following table presents the activity for those items measured at fair value on a recurring basis using Level 3 inputs during the three months ended March 31, 2018 and the year ended December 31, 2017: Three months ended Year ended Warrant Derivative Liabilities—Stock Purchase Warrants March 31, 2018 December 31, 2017 Balance, beginning of period $ 26,377,000 $ 10,600,000 Repurchased (6,186,000 ) — Change in fair value included in the statement of comprehensive loss (700,000 ) 15,777,000 Balance, end of period $ 19,491,000 $ 26,377,000 The value of the liability classified warrants, the value of warrant derivative liabilities and the change in fair value of the liability classified warrants and warrant derivative liabilities were determined using a Binomial Monte-Carlo Cliquet (aka “Ratchet”) Option Pricing Model. The model is similar to traditional Black-Scholes-type option pricing models, except that the exercise price resets at certain dates in the future. The values as of March 31, 2018, December 31, 2017 and the initial value as of September 11, 2013 were calculated based on the following assumptions: March 31, 2018 December 31, 2017 December 31, 2016 December 31, 2015 December 31, 2014 December 31, 2013 Initial Value Stock price $ 11.20 $ 11.40 $ 6.00 $ 4.70 $ 4.90 $ 3.60 $ 3.60 Risk‑free interest rate 2.06 % 1.62 % 1.09 % 1.23 % 1.38 % 1.75 % 1.72 % Expected volatility (peer group) 57.10 % 55.80 % 68.30 % 64.10 % 71.50 % 63.20 % 72.40 % Expected life (in years) 0.45 0.70 1.70 2.70 3.70 4.70 5.00 Expected dividend yield — — — — — — — Number outstanding 2,520,501 3,320,501 3,320,501 3,320,501 3,320,501 3,320,501 3,320,501 Balance, end of period: Liability classified warrants $ — $ — $ — $ — $ 3,206,000 $ 6,517,000 $ 7,541,000 Warrant derivative liabilities $ 19,491,000 $ 26,377,000 $ 10,600,000 $ 7,863,000 $ 6,520,000 $ — $ — The following table presents warrants issued in conjunction with Purchase Agreement with GPB measured at fair value as of March 31, 2018: Three months ended March 31, 2018 Year ended December 31, 2017 Liability Instrument—GPB Warrants Embedded Conversion Option Warrants Embedded Conversion Option Balance, beginning of period $ 1,882,000 $ 1,289,000 $ — $ — Fair value at issuance date — — 1,882,000 1,289,000 Change in fair value included in the statement of comprehensive income (loss) (140,000 ) (466,000 ) — — Extinguished upon debt repayment — (823,000 ) — — Balance, end of period $ 1,742,000 $ — $ 1,882,000 $ 1,289,000
Debt and related party debt	Debt and related party debt — The following table presents the effective interest rates on loans originated and refinanced in the respective periods that either had a beneficial conversion feature or an attached warrant: Type of Loan Term of Loan Stated Annual Interest Original Loan Principal Amount Conversion Rate Beneficial Conversion Discount Amount Warrants Issued with Notes Exercise Price Warrant FMV Discount Amount Effective Interest Rate Including Discounts 2017 convertible notes payable Due on demand - 3 years 10% - 13.5% $ 36,113,296 $3.50 - $10.31 $ 11,678,725 240,764 $ 10.80 $ 1,882,000 10% - 110% 2018 convertible notes payable Due on demand - 2 years 10% 16,511,998 $3.50 - $10.00 3,637,746 — — — 22% - 110% $ 52,625,294 $ 15,316,471 240,764 $ 1,882,000 Related party notes are disclosed as separate line items in the Company’s consolidated balance sheets.
Net loss per share	Net loss per share — As of March 31, 2018 and 2017, respectively, potentially dilutive securities exercisable or convertible into 17,122,176 and 15,554,439 shares of Company common stock were outstanding. No potentially dilutive securities were included in the calculation of diluted loss per share since their effect would be anti-dilutive for all periods presented.
Recent accounting pronouncements	Recent accounting pronouncements —In January 2016, the Financial Accounting Standards Board (“FASB”) issued Accounting Standards Update (“ASU”) No. 2016-01, Recognition and Measurement of Financial Assets and Financial Liabilities . The amendments applicable to the Company in this Update (1) supersede the guidance to classify equity securities, except equity method securities, with readily determinable fair values into trading or available-for-sale categories and require equity securities to be measured at fair value with changes in the fair value recognized through net income, (2) allow equity investments that do not have readily determinable fair values to be remeasured at fair value either upon the occurrence of an observable price change or upon identification of an impairment, (3) require assessment for impairment of equity investments without readily determinable fair values qualitatively at each reporting period, (4) eliminate the requirement to disclose the methods and significant assumptions used in calculating the fair value of financial instruments required to be disclosed for financial instruments measured at amortized cost on the balance sheet, (5) require public business entities to use the exit price notion when measuring the fair value of financial instruments for disclosure purposes, (6) require separate presentation of financial assets and financial liabilities by measurement category and form of financial asset (that is, securities or loans and receivables) on the balance sheet or the accompanying notes to the financial statements, (7) clarify that an entity should evaluate the need for a valuation allowance on a deferred tax asset related to available-for-sale securities in combination with the entity’s other deferred tax assets. This Update was effective beginning January 1, 2018 and the Company is now recognizing any changes in the fair value of certain equity investments in net income as prescribed by the new standard rather than in other comprehensive income. We recognized a cumulative effect adjustment to increase the opening balance of retained earnings as of January 1, 2018 by $41.4 million, net of $12.3 million income tax benefit. Refer to Note 4 for additional disclosures required by this ASU. In February 2016, the FASB issued ASU No. 2016-02, Leases In April 2016, the FASB issued ASU 2016-10, Revenue from Contracts with Customers (Topic 606): Identifying Performance Obligations and Licensing In August 2016, the FASB issued ASU No. 2016-15, Statement of Cash Flows (Topic 230), Classification of Certain Cash Receipts and Cash Payments In May 2017, the FASB issued ASU No. 2017-09, Compensation — Stock Compensation (Topic 718): Scope of Modification Accounting In February 2018, the FASB issued ASU No. 2018-02, Income Statement – Reporting Comprehensive Income (Topic 220): Reclassification of Certain Tax Effects from Accumulated Other Comprehensive Income In February 2018, the FASB issued ASU No. 2018-03, Technical Corrections and Improvements to Financial Instruments—Overall (Subtopic 825-10): Recognition and Measurement of Financial Assets and Financial Liabilities Fair Value Measurement Derivatives and Hedging— Embedded Derivatives Financial Instruments— Overall

SUMMARY OF SIGNIFICANT ACCOUN20

SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Tables)	3 Months Ended
	Mar. 31, 2018
Accounting Policies [Abstract]
Schedule of inventory	The below table presents inventory by category: Inventories by category March 31, 2018 December 31, 2017 Raw materials and components $ 106,486 $ — Work-in-process 506,475 124,801 Finished goods 451,281 504,365 Inventory reserve (55,802 ) (3,867 ) Total $ 1,008,440 $ 625,299
Schedule of prepaid expenses and other current assets	Prepaid expenses and other current assets consisted of the following at March 31, 2018 and December 31, 2017: March 31, December 31, 2018 2017 Prepaid insurance $ 68,391 $ 132,387 Other prepaid expenses and current assets 158,607 157,984 $ 226,998 $ 290,371
Schedule of other long-term liabilities	Other long-term liabilities consisted of the following at March 31, 2018 and December 31, 2017: At March 31, 2018 December 31, 2017 Trade discount $ 31,841,500 $ 31,841,500 Unearned revenue 10,000,000 5,000,000 Other long-term liabilities — 10,790 Total other long-term liabilities $ 41,841,500 $ 36,852,290
Schedule of changes in fair value of liabilities	Fair value measurements — The following table presents the activity for those items measured at fair value on a recurring basis using Level 3 inputs during the three months ended March 31, 2018 and the year ended December 31, 2017: Three months ended Year ended Warrant Derivative Liabilities—Stock Purchase Warrants March 31, 2018 December 31, 2017 Balance, beginning of period $ 26,377,000 $ 10,600,000 Repurchased (6,186,000 ) — Change in fair value included in the statement of comprehensive loss (700,000 ) 15,777,000 Balance, end of period $ 19,491,000 $ 26,377,000
Schedule of assumptions used in the valuation of warrants	The value of the liability classified warrants, the value of warrant derivative liabilities and the change in fair value of the liability classified warrants and warrant derivative liabilities were determined using a Binomial Monte-Carlo Cliquet (aka “Ratchet”) Option Pricing Model. The model is similar to traditional Black-Scholes-type option pricing models, except that the exercise price resets at certain dates in the future. The values as of March 31, 2018, December 31, 2017 and the initial value as of September 11, 2013 were calculated based on the following assumptions: March 31, 2018 December 31, 2017 December 31, 2016 December 31, 2015 December 31, 2014 December 31, 2013 Initial Value Stock price $ 11.20 $ 11.40 $ 6.00 $ 4.70 $ 4.90 $ 3.60 $ 3.60 Risk‑free interest rate 2.06 % 1.62 % 1.09 % 1.23 % 1.38 % 1.75 % 1.72 % Expected volatility (peer group) 57.10 % 55.80 % 68.30 % 64.10 % 71.50 % 63.20 % 72.40 % Expected life (in years) 0.45 0.70 1.70 2.70 3.70 4.70 5.00 Expected dividend yield — — — — — — — Number outstanding 2,520,501 3,320,501 3,320,501 3,320,501 3,320,501 3,320,501 3,320,501 Balance, end of period: Liability classified warrants $ — $ — $ — $ — $ 3,206,000 $ 6,517,000 $ 7,541,000 Warrant derivative liabilities $ 19,491,000 $ 26,377,000 $ 10,600,000 $ 7,863,000 $ 6,520,000 $ — $ —
Schedule of warrants issued in conjunction with Purchase Agreement with GPB	The following table presents warrants issued in conjunction with Purchase Agreement with GPB measured at fair value as of March 31, 2018: Three months ended March 31, 2018 Year ended December 31, 2017 Liability Instrument—GPB Warrants Embedded Conversion Option Warrants Embedded Conversion Option Balance, beginning of period $ 1,882,000 $ 1,289,000 $ — $ — Fair value at issuance date — — 1,882,000 1,289,000 Change in fair value included in the statement of comprehensive income (loss) (140,000 ) (466,000 ) — — Extinguished upon debt repayment — (823,000 ) — — Balance, end of period $ 1,742,000 $ — $ 1,882,000 $ 1,289,000
Schedule of notes payable with beneficial conversion feature or warrants	The following table presents the effective interest rates on loans originated and refinanced in the respective periods that either had a beneficial conversion feature or an attached warrant: Type of Loan Term of Loan Stated Annual Interest Original Loan Principal Amount Conversion Rate Beneficial Conversion Discount Amount Warrants Issued with Notes Exercise Price Warrant FMV Discount Amount Effective Interest Rate Including Discounts 2017 convertible notes payable Due on demand - 3 years 10% - 13.5% $ 36,113,296 $3.50 - $10.31 $ 11,678,725 240,764 $ 10.80 $ 1,882,000 10% - 110% 2018 convertible notes payable Due on demand - 2 years 10% 16,511,998 $3.50 - $10.00 3,637,746 — — — 22% - 110% $ 52,625,294 $ 15,316,471 240,764 $ 1,882,000

PROPERTY AND EQUIPMENT (Tables)

PROPERTY AND EQUIPMENT (Tables)	3 Months Ended
	Mar. 31, 2018
Property Plant And Equipment [Abstract]
Schedule of property and equipment	Property and equipment consisted of the following at: March 31, 2018 December 31, 2017 Equipment $ 237,449 $ 225,615 Leasehold improvements 64,394 61,054 Furniture and fixtures 74,090 74,090 Sub total 375,933 360,759 Less: accumulated depreciation (265,431 ) (255,457 ) Total $ 110,502 $ 105,302

INVESTMENTS (Tables)

INVESTMENTS (Tables)	3 Months Ended
	Mar. 31, 2018
Investments [Abstract]
Schedule of carrying values of equity securities	As of March 31, 2018, the carrying values of our equity securities were included in the following line items in our consolidated balance sheets: At March 31, 2018 Fair Value with Changes Recognized in Income Measurement Alternative - No Readily Determinable Fair Value Marketable securities $ 105,532,757 $ — Other investments — 565,202 Total equity securities $ 105,532,757 $ 565,202
Schedule of net unrealized gains and losses of equity securities	The calculation of net unrealized gains and losses for the period that relate to equity securities still held at March 31, 2018 is as follows: Three Months Ended March 31, 2018 Net gains (losses) recognized during the period related to equity securities $ 5,535,435 Less: Net gains (losses) recognized during the period related to equity securities sold during the period — Unrealized gains (losses) recognized during the period related to equity securities still held at the end of the period $ 5,535,435
Schedule of equity securities	As of December 31, 2017, equity securities consisted of the following: Gross Unrealized Estimated Cost Gains Losses Fair Value Trading securities $ — $ — $ — $ — Available-for-sale securities 46,209,017 60,812,231 (6,958,406 ) 100,062,842 Total equity securities $ 46,209,017 $ 60,812,231 $ (6,958,406 ) $ 100,062,842
Schedule of fair values of equity securities	As of December 31, 2017, the fair values of our equity securities were included in the following line items in our consolidated balance sheets: Trading Securities Available-for-sale securities Marketable securities $ — $ 99,997,322 Long-term investment at cost — 65,520 Total equity securities $ — $ 100,062,842

ACCOUNTS PAYABLE AND ACCRUED 23

ACCOUNTS PAYABLE AND ACCRUED EXPENSES (Tables)	3 Months Ended
	Mar. 31, 2018
Payables And Accruals [Abstract]
Schedule of accounts payable and accrued expenses	Accounts payable and accrued expenses consisted of the following at: March 31, 2018 December 31, 2017 Accounts payable: Regulatory fees $ — $ 715,999 Clinical and regulatory expenses 174,497 116,736 Commercialization consulting fees 12,321 30,000 Manufacturing cost 122,247 217,155 Legal expenses 68,703 87,701 Consulting fees 523,176 147,038 Accounting fees 86,799 67,293 Selling expenses 341,801 35,383 Investor relations and public relations expenses 36,812 45,526 Board member compensation 75,000 11,200 Other vendors 348,864 125,605 Total accounts payable 1,790,220 1,599,636 Accrued interest payable, related parties 346,901 318,120 Accrued interest payable 2,002,487 1,449,154 Accrued expenses: Wages and payroll taxes payable 118,453 1,711,541 Deferred salary 291,667 291,667 Paid vacation payable 241,071 186,978 Other accrued expenses 188,377 138,214 Total accrued expenses 839,568 2,328,400 Total accounts payable and accrued expenses $ 4,979,176 $ 5,695,310

NOTES PAYABLE (Tables)

NOTES PAYABLE (Tables)	3 Months Ended
	Mar. 31, 2018
Debt Disclosure [Abstract]
Schedule of notes payable	Notes payable consisted of the following at March 31, 2018 and December 31, 2017: Year Issued Interest Rate Range Term of Notes Conversion Price Principal Outstanding March 31, 2018 Discount Amount March 31, 2018 Carrying Amount March 31, 2018 Shares Underlying Notes March 31, 2018 Principal Outstanding December 31, 2017 Discount Amount December 31, 2017 Carrying Amount December 31, 2017 Shares Underlying Notes December 31, 2017 Notes payable 2013 10% Due on demand — $ 940,500 $ — $ 940,500 — $ 887,600 $ — $ 887,600 — 2015 10% Due on demand — 10,000 — 10,000 — — — — — 2016 10% - 11% Due on demand — 843,335 — 843,335 — 833,335 — 833,335 — 2017 11% Due on demand — 2,712,800 — 2,712,800 — 6,150,208 — 6,150,208 — $ 4,506,635 $ — $ 4,506,635 — $ 7,871,143 $ — $ 7,871,143 — Current $ 4,506,635 $ — $ 4,506,635 — $ 7,871,143 $ — $ 7,871,143 — Non-current $ — $ — $ — — $ — $ — $ — — Notes payable - related party 2015 11% Due on demand — 300,000 — 300,000 — 310,000 — 310,000 — 2016 10% - 11% Due on demand — 670,000 — 670,000 — 810,510 — 810,510 — 2017 10% Due on demand — 915,751 — 915,751 — 915,751 — 915,751 — 2018 11% Due on demand — 159,222 — 159,222 — — — — — $ 2,044,973 $ — $ 2,044,973 — $ 2,036,261 $ — $ 2,036,261 — Current $ 2,044,973 $ — $ 2,044,973 — $ 2,036,261 $ — $ 2,036,261 — Non-current $ — $ — $ — — $ — $ — $ — — Convertible notes payable 2011 10% 5 years $ 3.05 $ 300,000 $ — $ 300,000 98,285 $ 300,000 $ — $ 300,000 98,285 2014 10% Due on demand - 2 years $3.05 - $3.60 512,600 — 512,600 178,285 486,878 — 486,878 168,766 2016 10% Due on demand - 2 years $3.50 - $4.50 922,829 38,957 883,872 265,463 1,516,329 83,298 1,433,031 441,048 2017 10% Due on demand - 2 years $3.50 - $10.00 15,202,887 3,587,673 11,615,214 3,219,371 36,113,296 11,232,423 24,880,873 5,357,488 2018 10% Due on demand - 2 years $3.50 - $10.00 16,511,998 3,489,876 13,022,122 1,965,523 — $ 33,450,314 $ 7,116,506 $ 26,333,808 5,726,927 $ 38,416,503 $ 11,315,721 $ 27,100,782 6,065,587 Current $ 12,550,522 $ 3,541,922 $ 9,008,600 3,393,245 $ 12,860,912 $ 5,835,910 $ 7,025,002 3,449,984 Non-current $ 20,899,792 $ 3,574,584 $ 17,325,208 2,615,603 $ 25,555,591 $ 5,479,811 $ 20,075,780 2,615,603 Convertible notes payable - related party 2012 10% Due on demand $ 3.30 $ 200,000 $ — $ 200,000 69,616 $ 200,000 $ — $ 200,000 68,122 2015 10% 2 years $ 4.50 200,000 — 200,000 55,001 200,000 — 200,000 53,905 $ 400,000 $ — $ 400,000 124,617 $ 400,000 $ — $ 400,000 122,027 Current $ 400,000 $ — $ 400,000 122,027 $ 400,000 $ — $ 400,000 122,027 Non-current $ — $ — $ — — $ — $ — $ — — Grand Total $ 40,401,922 $ 7,116,506 $ 33,285,416 5,851,544 $ 48,723,907 $ 11,315,721 $ 37,408,186 6,187,614
Schedule of contractual principal payments of notes payable	Contractual principal payments due on notes payable are as follows: Year Ending Amount 2018 $ 19,174,057 2019 5,883,665 2020 15,344,200 Total $ 40,401,922
Schedule of fair value assumptions for warrants issued in conjunction with notes	The Company did not issue any warrants in conjunction with notes in the three months ended March 31, 2018. 2018 2017 Stock price — $ 11.40 Exercise price — $ 10.80 Term — 5 years Risk‑free interest rate — 2.20 % Expected dividend yield — — Expected volatility — 70.0 %

STOCKHOLDERS' DEFICIT (Tables)

STOCKHOLDERS' DEFICIT (Tables)	3 Months Ended
	Mar. 31, 2018
Stockholders Equity Note [Abstract]
Schedule of outstanding warrants	A summary of outstanding warrants as of March 31, 2018 and December 31, 2017 is presented below: Three months ended Year ended March 31, 2018 December 31, 2017 Warrants outstanding, beginning of period 5,265,432 5,024,668 Granted — 240,764 Exercised — — Cancelled, forfeited and expired (800,000 ) — Warrants outstanding, end of period 4,465,432 5,265,432 A summary of outstanding warrants by year issued and exercise price as of March 31, 2018 is presented below: Outstanding Exercisable Year issued and Exercise Price Number of Warrants Issued Weighted Average Remaining Contractual Life (Years) Weighted Average Exercise Price Total Weighted Average Exercise Price At December 31, 2013 $ 3.30 50,000 0.08 $ 3.30 50,000 $ 3.30 $ 3.50 1,822,693 0.45 $ 3.50 1,822,693 $ 3.50 2013 total 1,872,693 1,872,693 At December 31, 2014 $ 3.50 747,808 0.49 $ 3.50 747,808 $ 3.50 2014 Total 747,808 747,808 At December 31, 2015 $ 4.90 110,417 1.93 $ 4.90 110,417 $ 4.90 2015 Total 110,417 110,417 $ 4.50 118,750 3.25 $ 4.50 118,750 $ 4.50 $ 4.70 75,000 3.09 $ 4.70 75,000 $ 4.70 $ 5.00 1,300,000 3.11 $ 5.00 1,300,000 $ 5.00 2016 Total 1,493,750 1,493,750 At December 31, 2017 $ 10.80 240,764 5.25 $ 10.80 240,764 $ 10.80 At March 31, 2018 Total 4,465,432 4,465,432
Schedule of option activity	Summaries of outstanding options as of March 31, 2018 and December 31, 2017 are presented below. March 31, 2018 December 31, 2017 Number of Options Weighted‑ Average Exercise Price Number of Options Weighted‑ Average Exercise Price Options outstanding, beginning of period 6,775,200 $ 4.12 6,955,200 $ 4.10 Granted or deemed issued 30,000 $ 11.40 50,000 $ 11.40 Exercised — $ — (11,895 ) $ 4.19 Cancelled, forfeited and expired — $ — (218,105 ) $ 4.98 Options outstanding, end of period 6,805,200 $ 4.15 6,775,200 $ 4.12 Options exercisable at end of year 5,840,456 $ 3.99 5,604,439 $ 3.95 Options available for future grant 2,194,800 2,224,800

COMMITMENTS AND CONTINGENCIES (

COMMITMENTS AND CONTINGENCIES (Tables)	3 Months Ended
	Mar. 31, 2018
Commitments And Contingencies Disclosure [Abstract]
Schedule of future minimum lease payments	Future minimum lease payments under the agreements are as follows as of March 31, 2018: Year Amount 2018 (nine months) $ 238,673 2019 687,032 2020 611,012 2021 626,545 2022 646,047 Thereafter 777,344 Total $ 3,586,653

RELATED PARTY TRANSACTIONS (Tab

RELATED PARTY TRANSACTIONS (Tables)	3 Months Ended
	Mar. 31, 2018
Related Party Transactions [Abstract]
Schedule of outstanding loans from related persons	The following table sets forth information relating to our loans from related persons outstanding as of the date hereof or at any time during the three months ended March 31, 2018. Class Lender Interest Rate Date of Loan Term of Loan Principal Amount Outstanding at March 31, 2018 Highest Principal Outstanding Amount of Principal Repaid or Converted into Stock Amount of Interest Paid Conversion Rate Shares Underlying Notes March 31, 2018 Current, Promissory note payable to related parties: Masaharu & Emiko Osato (3) 11% 12/29/2015 Due on Demand 300,000 300,000 — — — — Masaharu & Emiko Osato (3) 11% 2/25/2016 Due on Demand 400,000 400,000 — — — — Lan T. Tran (2) 10% 4/29/2016 Due on Demand 20,000 20,000 — — — — Hope Hospice (1) 10% 6/3/2016 Due on Demand 250,000 250,000 — — — — Lan T. Tran (2) 10% 2/9/2017 Due on Demand 12,000 12,000 — — — — Yutaka Niihara (2)(3) 10% 9/14/2017 Due on Demand 903,751 903,751 — — — — Lan T. Tran (2) 10% 2/10/2018 Due on Demand 159,222 159,222 — — — — Subtotal $ 2,044,973 $ 3,571,078 $ 794,339 $ 129,470 Current, Convertible notes payable to related parties: Yasushi Nagasaki (2) 10% 6/29/2012 Due on Demand $ 200,000 $ 388,800 $ 188,800 $ 57,886 $ 3.30 69,616 Yutaka & Soomi Niihara (2)(3) 10% 11/16/2015 2 years 200,000 200,000 — — $ 4.50 55,001 Subtotal $ 400,000 $ 608,800 $ 208,800 $ 62,291 124,617 Total $ 2,444,973 $ 4,179,878 $ 1,003,139 $ 191,761 124,617 (1) Dr. Niihara, a director and officer of the Company, is also the Chief Executive Officer of Hope Hospice. (2) Officer. (3) Director. (4) Family of Officer/Director. The following table sets forth information relating to our loans from related persons outstanding as of the date hereof or at any time during the year ended December 31, 2017. Class Lender Interest Rate Date of Loan Term of Loan Principal Amount Outstanding at December 31, 2017 Highest Principal Outstanding Amount of Principal Repaid or Converted into Stock Amount of Interest Paid Conversion Rate Shares Underlying Notes December 31, 2017 Current, Promissory note payable to related parties: Hope Hospice (1) 8% 1/17/2012 Due on Demand $ — $ 200,000 $ 200,000 $ 7,331 — — Hope Hospice (1) 8% 6/14/2012 Due on Demand — 200,000 200,000 14,762 — — Hope Hospice (1) 8% 6/21/2012 Due on Demand — 100,000 100,000 7,249 — — Hope Hospice (1) 8% 2/11/2013 Due on Demand — 50,000 50,000 1,559 — — Hope Hospice (1) 10% 1/7/2015 Due on Demand — 100,000 100,000 28,630 — — IRA Service Trust Co. FBO Peter B. Ludlum (2) 10% 2/20/2015 Due on Demand 10,000 10,000 — — — — Masaharu & Emiko Osato (3) 11% 12/29/2015 Due on Demand 300,000 300,000 — — — — Yutaka Niihara (2)(3) 10% 5/21/2015 Due on Demand — 826,105 94,339 61,829 — — Lan T. Tran (2) 11% 2/10/2016 Due on Demand 130,510 130,510 — — — — Masaharu & Emiko Osato (3) 11% 2/25/2016 Due on Demand 400,000 400,000 — — — — Hope Hospice (1) 10% 4/4/2016 Due on Demand — 50,000 50,000 8,110 — — Lan T. Tran (2) 10% 4/29/2016 Due on Demand 20,000 20,000 — — — — IRA Service Trust Co. FBO Peter B. Ludlum (2) 10% 5/5/2016 Due on Demand 10,000 10,000 — — — — Hope Hospice (1) 10% 6/3/2016 Due on Demand 250,000 250,000 — — — — Lan T. Tran (2) 10% 2/9/2017 Due on Demand 12,000 12,000 — — — — Yutaka Niihara (2)(3) 10% 9/14/2017 Due on Demand 903,751 903,751 — — — — Subtotal $ 2,036,261 $ 3,562,366 $ 794,339 $ 129,470 — Current, Convertible notes payable to related parties: Yasushi Nagasaki (2) 10% 6/29/2012 Due on Demand $ 200,000 $ 388,800 $ 188,800 $ 57,886 $ 3.30 68,122 Charles & Kimxa Stark (2) 10% 10/1/2015 2 years — 20,000 20,000 4,405 $ 4.50 — Yutaka & Soomi Niihara (2)(3) 10% 11/16/2015 2 years 200,000 200,000 — — $ 4.50 53,905 Subtotal $ 400,000 $ 608,800 $ 208,800 $ 62,291 122,027 Total $ 2,436,261 $ 4,171,166 $ 1,003,139 $ 191,761 122,027 (1) Dr. Niihara, a director and officer of the Company, is also the Chief Executive Officer of Hope Hospice. (2) Officer (3) Director (4) Family of Officer/Director

GEOGRAPHIC INFORMATION (Tables)

GEOGRAPHIC INFORMATION (Tables)	3 Months Ended
	Mar. 31, 2018
Segment Reporting [Abstract]
Schedule of revenue earned from countries	For the three months ended March 31, 2018 and 2017, the Company earned revenue from countries as outlined in the table below: Country Revenue for the three months ended March 31, 2018 % of total revenue for the three months ended March 31, 2018 Revenue for the three months ended March 31, 2017 % of total revenue for the three months ended March 31, 2017 United States $ 675,046 86 % $ 14,619 13 % Japan 43,005 6 % 28,558 27 % Taiwan 26,100 3 % 64,300 60 % France 37,162 5 % — — %

SUBSEQUENT EVENTS (Tables)

SUBSEQUENT EVENTS (Tables)	3 Months Ended
	Mar. 31, 2018
Subsequent Events [Abstract]
Schedule of subsequent events	Subsequent to March 31, 2018, the Company issued the following: Notes Issued after March 31, 2018 Principal Amounts Annual Interest Rate Term of Notes Conversion Price Convertible note $ 250,000 10% 2 Years $ 10.00 Subsequent to March 31, 2018, the Company issued the following shares upon cashless exercise by a warrant holder: Common Shares Issued after March 31, 2018 Amounts Number of Shares Issued Common shares $ — 8,316

SUMMARY OF SIGNIFICANT ACCOUN30

SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Details Narrative)

Jan. 01, 2018USD ($)

Jun. 12, 2017USD ($)Number

Jun. 12, 2017KRW (₩)Number

Jul. 31, 2017USD ($)

Jul. 31, 2017KRW (₩)₩ / shares

Oct. 31, 2016USD ($)

Oct. 31, 2016KRW (₩)₩ / shares

Jan. 31, 2009USD ($)shares

Jan. 31, 2009JPY (¥)¥ / sharesshares

Mar. 31, 2018USD ($)VendorSecurity$ / sharesshares

Mar. 31, 2017USD ($)shares

Dec. 31, 2017USD ($)Vendor$ / sharesshares

Mar. 31, 2018¥ / shares

Mar. 31, 2018₩ / shares

Dec. 31, 2017¥ / shares

Dec. 31, 2017₩ / shares

Summary of Significant Accounting Policy [Line Items]

Number of vendor | Vendor

1

1

Advertising costs | $

$ 24,401

$ 8,391

Number of Marketable Securities | Security

4

Potentially dilutive securities outstanding

17,122,176

15,554,439

ASU 2016-01 [Member]

Summary of Significant Accounting Policy [Line Items]

Cumulative effect adjustment on adoption of ASU 2016-01 | $

$ 41,400,000

$ 41,400,000

Cumulative effect on retained earnings, tax | $

$ 12,300,000

12,300,000

Telcon, Inc. ("Telcon") [Member] | API Supply Agreement [Member]

Summary of Significant Accounting Policy [Line Items]

Proceeds from supply agreement | $

$ 31,800,000

Telcon, Inc. ("Telcon") [Member] | API Supply Agreement [Member] | Korea (South), Won

Summary of Significant Accounting Policy [Line Items]

Proceeds from supply agreement | ₩

₩ 36,000,000,000

Telcon, Inc. ("Telcon") [Member] | API Supply Agreement [Member] | Pharmaceutical Grade L-glutamine [Member]

Summary of Significant Accounting Policy [Line Items]

Percentage of right to supply

25.00%

25.00%

Agreement term

5 years

5 years

Number of renewals | Number

10

10

2011 Convertible notes payable [Member]

Summary of Significant Accounting Policy [Line Items]

Convertible notes payable, carrying amount | $

$ 300,000

$ 300,000

CellSeed, Inc. [Member]

Summary of Significant Accounting Policy [Line Items]

Shares held as marketable securities

39,250

Shares originally purchased (in shares)

147,100

147,100

Investment

$ 1,100,000

¥ 100,028,000

Investment, in per share | ¥ / shares

¥ 680

Investment, closing price | (per share)

$ 16.74

$ 4.10

¥ 1,780

¥ 462

Stock pledged against note

39,250

39,250

KPM Tech [Member]

Summary of Significant Accounting Policy [Line Items]

Shares held as marketable securities

849,744

Investment

$ 13,000,000

₩ 14,318,186,400

Investment, in per share | ₩ / shares

₩ 16,850

Investment, closing price | (per share)

$ 1.93

$ 1.52

₩ 2,050

₩ 1,625

Reverse stock split description

1-for-5 reverse stock split

Reverse stock split ratio

0.20

0.20

Hanil Vacuum [Member]

Summary of Significant Accounting Policy [Line Items]

Shares held as marketable securities

271,950

Investment

$ 1,000,000

₩ 1,101,397,500

Investment, in per share | ₩ / shares

₩ 4,050

Investment, closing price | (per share)

$ 2.23

$ 2.65

2,370

2,830

Telcon, Inc. ("Telcon") [Member]

Summary of Significant Accounting Policy [Line Items]

Shares held as marketable securities

6,643,559

Investment

$ 31,800,000

₩ 36,001,446,221

Investment, in per share | ₩ / shares

₩ 5,419

Investment, closing price | (per share)

$ 14.46

$ 13.95

₩ 15,350

₩ 14,900

Telcon, Inc. ("Telcon") [Member] | API Supply Agreement [Member]

Summary of Significant Accounting Policy [Line Items]

Proceeds from supply agreement | $

$ 31,800,000

Telcon, Inc. ("Telcon") [Member] | API Supply Agreement [Member] | Korea (South), Won

Summary of Significant Accounting Policy [Line Items]

Proceeds from supply agreement | ₩

₩ 36,000,000,000

Telcon, Inc. ("Telcon") [Member] | API Supply Agreement [Member] | Pharmaceutical Grade L-glutamine [Member]

Summary of Significant Accounting Policy [Line Items]

Percentage of right to supply

25.00%

25.00%

Agreement term

15 years

15 years

SUMMARY OF SIGNIFICANT ACCOUN31

SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Details 1) - USD ($)	Mar. 31, 2018	Dec. 31, 2017
Inventories by category
Raw materials and components	$ 106,486
Work-in-process	506,475	$ 124,801
Finished goods	451,281	504,365
Inventory reserve	(55,802)	(3,867)
Total	$ 1,008,440	$ 625,299

SUMMARY OF SIGNIFICANT ACCOUN32

SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Details 2) - USD ($)	Mar. 31, 2018	Dec. 31, 2017
Accounting Policies [Abstract]
Prepaid insurance	$ 68,391	$ 132,387
Other prepaid expenses and current assets	158,607	157,984
Prepaid expenses and other current assets	$ 226,998	$ 290,371

SUMMARY OF SIGNIFICANT ACCOUN33

SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Details 3) - USD ($)	Mar. 31, 2018	Dec. 31, 2017
Summary of Significant Accounting Policy [Line Items]
Other long-term liabilities	$ 41,841,500	$ 36,852,290
Other Long-Term Liabilities [Member]
Summary of Significant Accounting Policy [Line Items]
Other long-term liabilities		10,790
Unearned Revenue [Member]
Summary of Significant Accounting Policy [Line Items]
Other long-term liabilities	10,000,000	5,000,000
Trade Discount [Member]
Summary of Significant Accounting Policy [Line Items]
Other long-term liabilities	$ 31,841,500	$ 31,841,500

SUMMARY OF SIGNIFICANT ACCOUN34

SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Details 4) - USD ($)	3 Months Ended	12 Months Ended
	Mar. 31, 2018	Dec. 31, 2017
Warrant Derivative Liabilities - Stock Purchase Warrants [Member] | Level 3 [Member]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Balance, beginning of period	$ 26,377,000	$ 10,600,000
Repurchased	(6,186,000)
Change in fair value included in the statement of comprehensive loss	(700,000)	15,777,000
Balance, end of period	19,491,000	26,377,000
Liability Instrument - Warrants [Member] | GPB Debt Holdings II, LLC [Member]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Balance, beginning of period	1,882,000
Fair value at issuance date		1,882,000
Change in fair value included in the statement of comprehensive loss	(140,000)
Balance, end of period	1,742,000	1,882,000
Liability Instrument - Embedded Conversion Option [Member] | GPB Debt Holdings II, LLC [Member]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Balance, beginning of period	1,289,000
Fair value at issuance date		1,289,000
Change in fair value included in the statement of comprehensive loss	(466,000)
Extinguished upon debt repayment	$ (823,000)
Balance, end of period		$ 1,289,000

SUMMARY OF SIGNIFICANT ACCOUN35

SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Details 5) - Warrants [Member] - USD ($)	Sep. 11, 2013	Mar. 31, 2018	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Summary of Significant Accounting Policy [Line Items]
Stock price	$ 3.60	$ 11.20	$ 11.40	$ 6	$ 4.70	$ 4.90	$ 3.60
Risk‑free interest rate	1.72%	2.06%	1.62%	1.09%	1.23%	1.38%	1.75%
Expected volatility (peer group)	72.40%	57.10%	55.80%	68.30%	64.10%	71.50%	63.20%
Expected life (in years)	5 years	5 months 12 days	8 months 12 days	1 year 8 months 12 days	2 years 8 months 12 days	3 years 8 months 12 days	4 years 8 months 12 days
Number outstanding	3,320,501	2,520,501	3,320,501	3,320,501	3,320,501	3,320,501	3,320,501
Balance, end of period:
Liability classified warrants	$ 7,541,000					$ 3,206,000	$ 6,517,000
Warrant derivative liabilities		$ 19,491,000	$ 26,377,000	$ 10,600,000	$ 7,863,000	$ 6,520,000

SUMMARY OF SIGNIFICANT ACCOUN36

SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES (Details 6)	3 Months Ended
	Mar. 31, 2018USD ($)$ / shares$ / Warrantshares
Summary of Significant Accounting Policy [Line Items]
Original Loan Principal Amount	$ 52,625,294
Beneficial Conversion Discount Amount	$ 15,316,471
Warrants Issued with Notes (in shares) | shares	240,764
Warrant FMV Discount Amount	$ 1,882,000
Minimum [Member]
Summary of Significant Accounting Policy [Line Items]
Conversion Rate (in dollars per share) | $ / shares	$ 3.05
Maximum [Member]
Summary of Significant Accounting Policy [Line Items]
Conversion Rate (in dollars per share) | $ / shares	$ 10
2017 Convertible Notes Payable [Member]
Summary of Significant Accounting Policy [Line Items]
Original Loan Principal Amount	$ 36,113,296
Beneficial Conversion Discount Amount	$ 11,678,725
Warrants Issued with Notes (in shares) | shares	240,764
Exercise Price (in dollars per share) | $ / Warrant	10.80
Warrant FMV Discount Amount	$ 1,882,000
2017 Convertible Notes Payable [Member] | Minimum [Member]
Summary of Significant Accounting Policy [Line Items]
Term of Loan	Due on demand
Stated Annual Interest	10.00%
Conversion Rate (in dollars per share) | $ / shares	$ 3.50
Effective Interest Rate Including Discounts	10.00%
2017 Convertible Notes Payable [Member] | Maximum [Member]
Summary of Significant Accounting Policy [Line Items]
Term of Loans	3 years
Stated Annual Interest	13.50%
Conversion Rate (in dollars per share) | $ / shares	$ 10.31
Effective Interest Rate Including Discounts	110.00%
2018 Convertible Notes Payable [Member]
Summary of Significant Accounting Policy [Line Items]
Stated Annual Interest	10.00%
Original Loan Principal Amount	$ 16,511,998
Beneficial Conversion Discount Amount	$ 3,637,746
2018 Convertible Notes Payable [Member] | Minimum [Member]
Summary of Significant Accounting Policy [Line Items]
Term of Loan	Due on demand
Conversion Rate (in dollars per share) | $ / shares	$ 3.50
Effective Interest Rate Including Discounts	22.00%
2018 Convertible Notes Payable [Member] | Maximum [Member]
Summary of Significant Accounting Policy [Line Items]
Term of Loans	2 years
Conversion Rate (in dollars per share) | $ / shares	$ 10
Effective Interest Rate Including Discounts	110.00%

PROPERTY AND EQUIPMENT (Details

PROPERTY AND EQUIPMENT (Details) - USD ($)	Mar. 31, 2018	Dec. 31, 2017
Property and equipment
Property and equipment, gross	$ 375,933	$ 360,759
Less: accumulated depreciation	(265,431)	(255,457)
Property and equipment, net	110,502	105,302
Equipment [Member]
Property and equipment
Property and equipment, gross	237,449	225,615
Leasehold Improvements [Member]
Property and equipment
Property and equipment, gross	64,394	61,054
Furniture and Fixtures [Member]
Property and equipment
Property and equipment, gross	$ 74,090	$ 74,090

PROPERTY AND EQUIPMENT (Detai38

PROPERTY AND EQUIPMENT (Details Narrative) - USD ($)	3 Months Ended
	Mar. 31, 2018	Mar. 31, 2017
Property Plant And Equipment [Abstract]
Depreciation expense	$ 13,055	$ 5,308

INVESTMENTS (Details Narrative)

INVESTMENTS (Details Narrative) - USD ($)	Jan. 01, 2018	Mar. 31, 2018	Dec. 31, 2017	Mar. 31, 2017
Schedule Of Investments [Line Items]
Marketable equity securities classified as trading, value			$ 0
Cost method investments, carrying value			65,520
Equity securities		$ 105,532,757	$ 100,062,842	$ 0
ASU 2016-01 [Member]
Schedule Of Investments [Line Items]
Cumulative effect adjustment on adoption of ASU 2016-01	$ 41,400,000	41,400,000
Cumulative effect on retained earnings, tax	$ 12,300,000	$ 12,300,000

INVESTMENTS (Details 1)

INVESTMENTS (Details 1) - USD ($)	Mar. 31, 2018	Dec. 31, 2017	Mar. 31, 2017
Schedule Of Investments [Line Items]
Equity securities	$ 105,532,757	$ 100,062,842	$ 0
Other investments	565,202
Total equity securities	565,202
Marketable Equity Securties [Member]
Schedule Of Investments [Line Items]
Equity securities	$ 105,532,757	$ 99,997,322

INVESTMENTS (Details 2)

INVESTMENTS (Details 2) - USD ($)	3 Months Ended	12 Months Ended
	Mar. 31, 2018	Dec. 31, 2017
Investments [Abstract]
Unrealized gain on investment in marketable securities	$ 5,535,435	$ 100,062,842
Unrealized gains (losses) recognized during the period related to equity securities still held at the end of the period	$ 5,535,435

INVESTMENTS (Details 3)

INVESTMENTS (Details 3) - USD ($)	3 Months Ended	12 Months Ended
	Mar. 31, 2018	Dec. 31, 2017
Investments [Abstract]
Available-for-sale securities		$ 46,209,017
Total equity securities		46,209,017
Available-for-sale securities		60,812,231
Total equity securities		60,812,231
Available-for-sale securities		(6,958,406)
Total equity securities		(6,958,406)
Available-for-sale securities		100,062,842
Total equity securities	$ 5,535,435	$ 100,062,842

INVESTMENTS (Details 4)

INVESTMENTS (Details 4) - USD ($)	Mar. 31, 2018	Dec. 31, 2017	Mar. 31, 2017
Schedule Of Investments [Line Items]
Trading Securities		$ 0
Available-for-sale securities	$ 105,532,757	100,062,842	$ 0
Marketable Equity Securties [Member]
Schedule Of Investments [Line Items]
Available-for-sale securities	$ 105,532,757	99,997,322
Long-Term Investment At Cost [Member]
Schedule Of Investments [Line Items]
Available-for-sale securities		$ 65,520

ACCOUNTS PAYABLE AND ACCRUED 44

ACCOUNTS PAYABLE AND ACCRUED EXPENSES (Details) - USD ($)	Mar. 31, 2018	Dec. 31, 2017
Accounts payable:
Regulatory fees		$ 715,999
Clinical and regulatory expenses	$ 174,497	116,736
Commercialization consulting fees	12,321	30,000
Manufacturing cost	122,247	217,155
Legal expenses	68,703	87,701
Consulting fees	523,176	147,038
Accounting fees	86,799	67,293
Selling expenses	341,801	35,383
Investor relations and public relations expenses	36,812	45,526
Board member compensation	75,000	11,200
Other vendors	348,864	125,605
Total accounts payable	1,790,220	1,599,636
Accrued interest payable, related parties	346,901	318,120
Accrued interest payable	2,002,487	1,449,154
Accrued expenses:
Wages and payroll taxes payable	118,453	1,711,541
Deferred salary	291,667	291,667
Paid vacation payable	241,071	186,978
Other accrued expenses	188,377	138,214
Total accrued expenses	839,568	2,328,400
Total accounts payable and accrued expenses	$ 4,979,176	$ 5,695,310

NOTES PAYABLE (Details)

NOTES PAYABLE (Details)	3 Months Ended	12 Months Ended
	Mar. 31, 2018USD ($)Number$ / shares	Dec. 31, 2017USD ($)Number
Principal Outstanding	$ 40,401,922	$ 48,723,907
Discount Amount	7,116,506	11,315,721
Carrying Amount	$ 33,285,416	$ 37,408,186
Shares Underlying Principal | Number	5,851,544	6,187,614
Notes payable, current	$ 4,506,635	$ 7,871,143
Minimum [Member]
Conversion Price | $ / shares	$ 3.05
Maximum [Member]
Conversion Price | $ / shares	$ 10
2013 Notes payable [Member]
Interest rate	10.00%
Term of Notes	Due on demand
Principal Outstanding	$ 940,500	887,600
Carrying Amount	$ 940,500	887,600
2015 Notes payable [Member]
Interest rate	10.00%
Term of Notes	Due on demand
Principal Outstanding	$ 10,000
Carrying Amount	$ 10,000
2016 Notes payable [Member]
Term of Notes	Due on demand
Principal Outstanding	$ 843,335	833,335
Carrying Amount	$ 843,335	833,335
2016 Notes payable [Member] | Minimum [Member]
Interest rate	10.00%
2016 Notes payable [Member] | Maximum [Member]
Interest rate	11.00%
2017 Notes payable [Member]
Interest rate	11.00%
Term of Notes	Due on demand
Principal Outstanding	$ 2,712,800	6,150,208
Carrying Amount	2,712,800	6,150,208
Notes Payable [Member]
Principal Outstanding	4,506,635	7,871,143
Carrying Amount	4,506,635	7,871,143
Principal Outstanding, Current	4,506,635	7,871,143
Notes payable, current	$ 4,506,635	7,871,143
2015 Notes payable - related party [Member]
Interest rate	11.00%
Term of Notes	Due on demand
Principal Outstanding	$ 300,000	310,000
Carrying Amount	$ 300,000	310,000
2016 Notes payable - related party [Member]
Term of Notes	Due on demand
Principal Outstanding	$ 670,000	810,510
Carrying Amount	$ 670,000	810,510
2016 Notes payable - related party [Member] | Minimum [Member]
Interest rate	10.00%
2016 Notes payable - related party [Member] | Maximum [Member]
Interest rate	11.00%
2017 Notes payable - related party [Member]
Interest rate	10.00%
Term of Notes	Due on demand
Principal Outstanding	$ 915,751	915,751
Carrying Amount	$ 915,751	915,751
2018 Notes payable - related party [Member]
Interest rate	11.00%
Term of Notes	Due on demand
Principal Outstanding	$ 159,222
Carrying Amount	159,222
Notes payable - related party [Member]
Principal Outstanding	2,044,973	2,036,261
Carrying Amount	2,044,973	2,036,261
Principal Outstanding, Current	2,044,973	2,036,261
Notes payable, current	$ 2,044,973	$ 2,036,261

NOTES PAYABLE (Details 1)

NOTES PAYABLE (Details 1)		3 Months Ended		12 Months Ended
		Mar. 31, 2018USD ($)Number$ / shares		Dec. 31, 2017USD ($)Number
Principal Outstanding		$ 40,401,922		$ 48,723,907
Discount Amount		7,116,506		11,315,721
Carrying Amount		$ 33,285,416		$ 37,408,186
Shares Underlying Principal | Number		5,851,544		6,187,614
Convertible notes payable, Current		$ 9,008,600		$ 7,025,002
Convertible notes payable, Non Current		$ 17,325,208		20,075,780
Minimum [Member]
Conversion Price | $ / shares		$ 3.05
Maximum [Member]
Conversion Price | $ / shares		$ 10
2011 Convertible notes payable [Member]
Interest rate		10.00%
Term of Notes		5 years
Conversion Price | $ / shares		$ 3.05
Principal Outstanding		$ 300,000		300,000
Carrying Amount		$ 300,000		$ 300,000
Shares Underlying Principal | Number		98,285		98,285
2014 Convertible notes payable [Member]
Interest rate		10.00%
Principal Outstanding		$ 512,600		$ 486,878
Carrying Amount		$ 512,600		$ 486,878
Shares Underlying Principal | Number		178,285		168,766
2014 Convertible notes payable [Member] | Minimum [Member]
Term of Notes		Due on demand
Conversion Price | $ / shares		$ 3.05
2014 Convertible notes payable [Member] | Maximum [Member]
Term of Notes		2 years
Conversion Price | $ / shares		$ 3.60
2016 Convertible Notes Payable [Member]
Interest rate		10.00%
Principal Outstanding		$ 922,829		$ 1,516,329
Discount Amount		38,957		83,298
Carrying Amount		$ 883,872		$ 1,433,031
Shares Underlying Principal | Number		265,463		441,048
2016 Convertible Notes Payable [Member] | Minimum [Member]
Term of Notes		Due on demand
Conversion Price | $ / shares		$ 3.50
2016 Convertible Notes Payable [Member] | Maximum [Member]
Term of Notes		2 years
Conversion Price | $ / shares		$ 4.50
2017 Convertible Notes Payable [Member]
Interest rate		10.00%
Principal Outstanding		$ 15,202,887		$ 36,113,296
Discount Amount		3,587,673		11,232,423
Carrying Amount		$ 11,615,214		$ 24,880,873
Shares Underlying Principal | Number		3,219,371		5,357,488
2017 Convertible Notes Payable [Member] | Minimum [Member]
Term of Notes		Due on demand
Conversion Price | $ / shares		$ 3.50
2017 Convertible Notes Payable [Member] | Maximum [Member]
Term of Notes		2 years
Conversion Price | $ / shares		$ 10
2018 Convertible Notes Payable [Member]
Interest rate		10.00%
Principal Outstanding		$ 16,511,998
Discount Amount		3,489,876
Carrying Amount		$ 13,022,122
Shares Underlying Principal | Number		1,965,523
2018 Convertible Notes Payable [Member] | Minimum [Member]
Term of Notes		Due on demand
Conversion Price | $ / shares		$ 3.50
2018 Convertible Notes Payable [Member] | Maximum [Member]
Term of Notes		2 years
Conversion Price | $ / shares		$ 10
Convertible Notes Payable [Member]
Principal Outstanding		$ 33,450,314		$ 38,416,503
Discount Amount		7,116,506		11,315,721
Carrying Amount		$ 26,333,808		$ 27,100,782
Shares Underlying Principal | Number		5,726,927		6,065,587
Principal Outstanding, Current		$ 12,550,522		$ 12,860,912
Principal Outstanding, Non Current		20,899,792		25,555,591
Discount Amount Current		3,541,922		5,835,910
Discount Amount Non Current		3,574,584		5,479,811
Convertible notes payable, Current		9,008,600		7,025,002
Convertible notes payable, Non Current		$ 17,325,208		$ 20,075,780
Shares Underlying Principal Current | Number		3,393,245		3,449,984
Shares Underlying Principal Non Current | Number		2,615,603		2,615,603
2012 Convertible notes payable - related party [Member]
Interest rate		10.00%
Term of Notes		Due on demand
Conversion Price | $ / shares		$ 3.30
Principal Outstanding		$ 200,000		$ 200,000
Carrying Amount		$ 200,000		$ 200,000
Shares Underlying Principal | Number		69,616		68,122
2015 Convertible notes payable - related party [Member]
Interest rate		10.00%
Term of Notes		2 years
Conversion Price | $ / shares		$ 4.50
Principal Outstanding		$ 200,000		$ 200,000
Carrying Amount		$ 200,000		$ 200,000
Shares Underlying Principal | Number		55,001		53,905
Convertible notes payable - related party [Member]
Term of Notes	[1],[2]	2 years
Principal Outstanding		$ 400,000		$ 400,000
Carrying Amount		$ 400,000	[1],[2]	$ 400,000
Shares Underlying Principal | Number		124,617	[1],[2]	122,027
Principal Outstanding, Current		$ 400,000		$ 400,000
Convertible notes payable, Current		$ 400,000		$ 400,000
Shares Underlying Principal Current | Number		122,027		122,027
[1]	Director.
[2]	Officer.

NOTES PAYABLE (Details Narrativ

NOTES PAYABLE (Details Narrative) - $ / shares	3 Months Ended
	Mar. 31, 2018	Dec. 31, 2017
Average stated interest rate	10.00%	11.00%
Average effective interest rate	37.00%	24.00%
Description of debt conversion	Certain notes with a $4.50 or a $10.00 stated conversion price in the second year of their two-year term are subject to automatic conversion into shares of Company common stock at a conversion price equal to 80% of the initial public offering price at the time of a qualified public offering.
Percentage of initial public offering price	80.00%
Warrants [Member]
Method of calculation of fair value of warrants	Black Scholes Merton Option Pricing Model
Minimum [Member]
Conversion Price	$ 3.05
Maximum [Member]
Conversion Price	$ 10

NOTES PAYABLE (Details 2)

NOTES PAYABLE (Details 2)	Mar. 31, 2018USD ($)
Long Term Debt By Maturity [Abstract]
2,018	$ 19,174,057
2,019	5,883,665
2,020	15,344,200
Total	$ 40,401,922

NOTES PAYABLE (Details 3)

NOTES PAYABLE (Details 3) - Warrants [Member] - $ / shares	Sep. 11, 2013	Mar. 31, 2018	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Stock price	$ 3.60	$ 11.20	$ 11.40	$ 6	$ 4.70	$ 4.90	$ 3.60
Term	5 years	5 months 12 days	8 months 12 days	1 year 8 months 12 days	2 years 8 months 12 days	3 years 8 months 12 days	4 years 8 months 12 days
Risk‑free interest rate	1.72%	2.06%	1.62%	1.09%	1.23%	1.38%	1.75%
Expected volatility	72.40%	57.10%	55.80%	68.30%	64.10%	71.50%	63.20%
Convertible Notes Payable [Member]
Stock price			$ 11.40
Exercise price			$ 10.80
Term			5 years
Risk‑free interest rate			2.20%
Expected volatility			70.00%

STOCKHOLDERS' DEFICIT (Details

STOCKHOLDERS' DEFICIT (Details Narrative) - USD ($)	Mar. 29, 2018	Dec. 29, 2017	Sep. 29, 2016	Sep. 12, 2016	Jun. 10, 2015	Jun. 10, 2014	Sep. 11, 2013	Mar. 31, 2018	Mar. 31, 2017	Dec. 31, 2017	Dec. 31, 2016	Sep. 11, 2014	Jun. 10, 2010
Warrants outstanding								4,465,432
Fair value of outstanding warrants								$ 19,491,000
Warrants Issued with Notes (in shares)								240,764
Exercise price - options vested								$ 11.40
Share-based compensation								$ 709,958	$ 1,028,350
Period remaining for recognition of unrecognized compensation cost								1 year 2 months 12 days
Letter of Agreement [Member] | K P M Tech Co
Common stock price				$ 15.32
Future capital increases				$ 13,000,000
Letter of Agreement [Member] | Hanil Vacuum Co
Common stock price				$ 3.68
Future capital increases				$ 1,000,000
GPB Debt Holdings II, LLC [Member] | Purchase Warrant [Member]
Percent of product of registrable securities and closing sale price liable upon non registration as liquidation damages		2.00%
GPB Debt Holdings II, LLC [Member] | Purchase Warrant [Member] | Maximum [Member]
Penalty percent of product of registrable securities and closing sale price liable upon non registration as liquidation damages		12.00%
2011 Stock Incentive Option Plan [Member]
Options granted										50,000
Exercise price - options vested								$ 11.40		$ 11.40
Exercise price - options								$ 4.15		$ 4.12	$ 4.10
Options outstanding								6,805,200		6,775,200	6,955,200
Total unrecognized compensation cost								$ 6,800,000
2011 Stock Incentive Option Plan [Member] | Employee Stock Option
Options granted								30,000
2011 Stock Incentive Option Plan [Member] | Equity Option
Share-based compensation								$ 700,000	$ 1,000,000
Private Placement
Units issued in offering (in units)							3,020,501
Unit price of offering (in dollars per share)							2.50
Units issued in offering							$ 7,551,253
Warrants issued to broker of the offering							300,000
Exercise price						$ 3.50	$ 3.50
Warrants outstanding												2,225,036
Fair value of outstanding warrants						$ 1,800,000						$ 7,068,000
Number of warrants exercised						1,095,465
Proceeds from exercise of warrants						$ 3,800,000
Issuance of common stock for exercise of warrants						1,095,465
Adjustment to additional paid-in capital - warrants						$ 1,800,000
Private Placement | Letter of Agreement [Member]
Future capital investment				13,000,000
Reduction in additional paid in capital			$ 720,000
Private Placement | Letter of Agreement [Member] | K P M Tech Co
Purchase of common stock				$ 17,000,000
Common stock price				$ 4.50
Number of shares issued			3,777,778
Private Placement | Letter of Agreement [Member] | Hanil Vacuum Co
Purchase of common stock				$ 3,000,000
Future capital investment				$ 1,000,000
Number of shares issued			666,667
Private Placement | Letter of Agreement [Member] | K P M Tech Co And Hanil Vacuum Co
Purchase of common stock			$ 20,000,000
Private Placement | Common Class A
Common stock subscription													4,115,966
Private Placement | Warrant
Warrants outstanding								2,520,501
Common stock subscription													3,320,501
Share price								$ 11.20
Warrants cancelled	800,000
Private Placement | Warrant | Maximum [Member]
Share price								$ 12.20
Number of shares callable by warrants								1,797,406
Private Placement | Warrant | Minimum [Member]
Share price								$ 11.20
Number of shares callable by warrants								1,732,844
Increase in share price								$ 1
Private Placement | Replacement Warrants [Member]
Exercise price													$ 3.50
Private Placement | Replacement Warrants [Member]
Exercise price						$ 3.50
Warrants outstanding					1,095,465
Fair value of outstanding warrants					$ 2,545,000
Warrants Issued with Notes (in shares)						1,095,465
Warrant exercise inducement expense					$ 3,500,000

STOCKHOLDERS' DEFICIT (Details)

STOCKHOLDERS' DEFICIT (Details) - shares	3 Months Ended	12 Months Ended
	Mar. 31, 2018	Dec. 31, 2017
Warrants outstanding, ending	4,465,432
Warrant
Warrants outstanding, beginning	5,265,432	5,024,668
Granted		240,764
Cancelled, forfeited and expired	(800,000)
Warrants outstanding, ending	4,465,432	5,265,432

STOCKHOLDERS' DEFICIT (Detail52

STOCKHOLDERS' DEFICIT (Details 1)	3 Months Ended
	Mar. 31, 2018$ / sharesshares
Outstanding	4,465,432
Exercisable	4,465,432
Warrants Issued in 2013 - Exercise Price $3.30 [Member]
Outstanding	50,000
Outstanding	29 days
Outstanding | $ / shares	$ 3.30
Exercisable	50,000
Exercisable | $ / shares	$ 3.30
Warrants Issued in 2013 - Exercise Price $3.50 [Member]
Outstanding	1,822,693
Outstanding	5 months 12 days
Outstanding | $ / shares	$ 3.50
Exercisable	1,822,693
Exercisable | $ / shares	$ 3.50
Warrants Issued in 2013 [Member]
Outstanding	1,872,693
Exercisable	1,872,693
Warrants Issued in 2014 - Exercise Price $3.50 [Member]
Outstanding	747,808
Outstanding	5 months 26 days
Outstanding | $ / shares	$ 3.50
Exercisable	747,808
Exercisable | $ / shares	$ 3.50
Warrants Issued in 2014 [Member]
Outstanding	747,808
Exercisable	747,808
Warrants Issued in 2015 - Exercise Price $4.90 [Member]
Outstanding	110,417
Outstanding	1 year 11 months 4 days
Outstanding | $ / shares	$ 4.90
Exercisable	110,417
Exercisable | $ / shares	$ 4.90
Warrants Issued in 2015 [Member]
Outstanding	110,417
Exercisable	110,417
Warrants Issued in 2016 - Exercise Price $4.50 [Member]
Outstanding	118,750
Outstanding	3 years 2 months 30 days
Outstanding | $ / shares	$ 4.50
Exercisable	118,750
Exercisable | $ / shares	$ 4.50
Warrants Issued in 2016 - Exercise Price $4.70 [Member]
Outstanding	75,000
Outstanding	3 years 1 month 2 days
Outstanding | $ / shares	$ 4.70
Exercisable	75,000
Exercisable | $ / shares	$ 4.70
Warrants Issued in 2016 - Exercise Price $5.00 [Member]
Outstanding	1,300,000
Outstanding	3 years 1 month 9 days
Outstanding | $ / shares	$ 5
Exercisable	1,300,000
Exercisable | $ / shares	$ 5
Warrants Issued in 2016 [Member]
Outstanding	1,493,750
Exercisable	1,493,750
Warrants Issued in 2017 - Exercise Price $ 10.80 [Member]
Outstanding	240,764
Outstanding	5 years 2 months 30 days
Outstanding | $ / shares	$ 10.80
Exercisable	240,764
Exercisable | $ / shares	$ 10.80

STOCKHOLDERS' DEFICIT (Detail53

STOCKHOLDERS' DEFICIT (Details 3) - $ / shares	3 Months Ended	12 Months Ended
	Mar. 31, 2018	Dec. 31, 2017
Exercise price - options vested	$ 11.40
2011 Stock Incentive Option Plan [Member]
Options outstanding, beginning	6,775,200	6,955,200
Granted or deemed issued	30,000	50,000
Exercised		(11,895)
Cancelled, forfeited and expired		(218,105)
Options outstanding, end	6,805,200	6,775,200
Options exercisable	5,840,456	5,604,439
Options available for future grant	2,194,800	2,224,800
Options outstanding, beginning	$ 4.12	$ 4.10
Exercise price - options vested	11.40	11.40
Exercised		4.19
Cancelled, forfeited and expired		4.98
Options outstanding, end	4.15	4.12
Options exercisable	$ 3.99	$ 3.95

COMMITMENTS AND CONTINGENCIES54

COMMITMENTS AND CONTINGENCIES (Details Narrative)	Jul. 12, 2017USD ($)Numberkg$ / kg	Jun. 12, 2017USD ($)$ / sharesshares	Jun. 12, 2017KRW (₩)₩ / shares	Jul. 31, 2017USD ($)	Jul. 31, 2017KRW (₩)₩ / shares	Mar. 31, 2018USD ($)$ / shares	Mar. 31, 2017USD ($)	Mar. 31, 2018₩ / shares	Dec. 31, 2017$ / shares	Dec. 31, 2017₩ / shares	Sep. 29, 2016USD ($)
Rent expense						$ 124,286	$ 151,312
Telcon, Inc. ("Telcon") [Member]
Investment				$ 31,800,000	₩ 36,001,446,221
Investment, in per share | ₩ / shares					₩ 5,419
Investment, closing price | (per share)						$ 14.46		₩ 15,350	$ 13.95	₩ 14,900
Telcon, Inc. ("Telcon") [Member] | Bridge Loan [Member]
Bridge loan borrowing capacity											$ 3,500,000
Interest rate											5.00%
Receivable from distribution agreement trigger											$ 5,000,000
Collaterized debt - security interest											$ 10,000,000
Telcon, Inc. ("Telcon") [Member] | Management Control Acquistion Agreement [Member]
Investment		$ 31,800,000
Investment, closing price | $ / shares		$ 4.79
Ownership interest		10.30%
Telcon, Inc. ("Telcon") [Member] | Management Control Acquistion Agreement [Member] | Korea (South), Won
Investment | ₩			₩ 36,000,000,000
Shares originally purchased (in shares) | shares		6,643,559
Investment, in per share | ₩ / shares			₩ 5,419
Telcon, Inc. ("Telcon") [Member] | API Supply Agreement [Member]
Proceeds from supply agreement		$ 31,800,000
Telcon, Inc. ("Telcon") [Member] | API Supply Agreement [Member] | Pharmaceutical Grade L-glutamine [Member]
Percentage of right to supply		25.00%	25.00%
Agreement term		15 years	15 years
Telcon, Inc. ("Telcon") [Member] | API Supply Agreement [Member] | Korea (South), Won
Proceeds from supply agreement | ₩			₩ 36,000,000,000
Telcon, Inc. ("Telcon") [Member] | Revised API Agreement [Member]
Agreement term	5 years
Number of renewals | Number	10
Weight of drug per supply agreement | kg	940,000
Unit price of grade L-glutamine | $ / kg	50
Purchase amount	$ 47,000,000
Telcon, Inc. ("Telcon") [Member] | Revised API Agreement [Member] | Maximum [Member]
Agreement term	15 years
Yearly purchase commitments	$ 2,500,000
Telcon, Inc. ("Telcon") [Member] | Revised API Agreement [Member] | Minimum [Member]
Yearly purchase commitments	$ 5,000,000

COMMITMENTS AND CONTINGENCIES55

COMMITMENTS AND CONTINGENCIES (Details)	Mar. 31, 2018USD ($)
Future minimum lease payments
2018 (nine months)	$ 238,673
2,019	687,032
2,020	611,012
2,021	626,545
2,022	646,047
Thereafter	777,344
Total	$ 3,586,653

RELATED PARTY TRANSACTIONS (Det

RELATED PARTY TRANSACTIONS (Details)		3 Months Ended		12 Months Ended
		Mar. 31, 2018USD ($)Number$ / shares		Dec. 31, 2017USD ($)Number$ / shares
Short-term Debt [Line Items]
Principal Amount Outstanding		$ 33,285,416		$ 37,408,186
Shares Underlying Principal | Number		5,851,544		6,187,614
Masaharu & Emiko Osato [Member]
Short-term Debt [Line Items]
Interest Rate		11.00%	[1]	11.00%	[2]
Date of Loan		Dec. 29, 2015	[1]	Dec. 29, 2015	[2]
Term of Loan	[1]	Due on Demand
Principal Amount Outstanding		$ 300,000	[1]	$ 300,000	[2]
Highest Principal Outstanding		$ 300,000	[1]	$ 300,000	[2]
Masaharu & Emiko Osato [Member]
Short-term Debt [Line Items]
Interest Rate		11.00%	[1]	11.00%	[2]
Date of Loan		Feb. 25, 2016	[1]	Feb. 25, 2016	[2]
Term of Loan	[1]	Due on Demand
Principal Amount Outstanding		$ 400,000	[1]	$ 400,000	[2]
Highest Principal Outstanding		$ 400,000	[1]	$ 400,000	[2]
Lan T. Tran [Member]
Short-term Debt [Line Items]
Interest Rate		10.00%	[1]	11.00%	[3]
Date of Loan		Apr. 29, 2016	[1]	Feb. 10, 2016	[3]
Term of Loan	[1]	Due on Demand
Principal Amount Outstanding		$ 20,000	[1]	$ 130,510	[3]
Highest Principal Outstanding		$ 20,000	[1]	$ 130,510	[3]
Hope Hospice [Member]
Short-term Debt [Line Items]
Interest Rate	[1]	10.00%		10.00%
Date of Loan	[1]	Jun. 3, 2016		Apr. 4, 2016
Term of Loan	[1]	Due on Demand
Principal Amount Outstanding	[1]	$ 250,000
Highest Principal Outstanding	[1]	$ 250,000		$ 50,000
Amount of Principal Repaid	[1]			50,000
Amount of Interest Paid	[1]			$ 8,110
Lan T. Tran [Member]
Short-term Debt [Line Items]
Interest Rate		10.00%	[1]	10.00%	[3]
Date of Loan		Feb. 9, 2017	[1]	Apr. 29, 2016	[3]
Term of Loan	[1]	Due on Demand
Principal Amount Outstanding		$ 12,000	[1]	$ 20,000	[3]
Highest Principal Outstanding		$ 12,000	[1]	$ 20,000	[3]
Yutaka Niihara [Member]
Short-term Debt [Line Items]
Interest Rate	[2]	10.00%		10.00%	[3]
Date of Loan	[2]	Sep. 14, 2017		Sep. 14, 2017	[3]
Term of Loan	[2]	Due on Demand
Principal Amount Outstanding	[2]	$ 903,751		$ 903,751	[3]
Highest Principal Outstanding	[2]	$ 903,751		903,751	[3]
Lan T. Tran [Member]
Short-term Debt [Line Items]
Interest Rate	[2],[3]	10.00%
Date of Loan	[2],[3]	Feb. 10, 2018
Term of Loan	[2],[3]	Due on Demand
Principal Amount Outstanding		$ 159,222	[2],[3]	2,036,261
Highest Principal Outstanding		$ 159,222	[2],[3]	3,562,366
Amount of Principal Repaid				794,339
Amount of Interest Paid				$ 129,470
Promissory Note Payable To Related Parties [Member]
Short-term Debt [Line Items]
Interest Rate	[3]			10.00%
Date of Loan	[3]			Feb. 9, 2017
Term of Loan	[2]	Subtotal
Principal Amount Outstanding		$ 2,044,973	[2]	$ 12,000	[3]
Highest Principal Outstanding		3,571,078	[2]	$ 12,000	[3]
Amount of Principal Repaid	[2]	794,339
Amount of Interest Paid	[2]	$ 129,470
Yasushi Nagasaki [Member]
Short-term Debt [Line Items]
Interest Rate	[3]	10.00%		10.00%
Date of Loan	[3]	Jun. 29, 2012		Jun. 29, 2012
Term of Loan	[3]	Due on Demand
Principal Amount Outstanding	[3]	$ 200,000		$ 200,000
Highest Principal Outstanding	[3]	388,800		388,800
Amount of Principal Repaid	[3]	188,800		188,800
Amount of Interest Paid	[3]	$ 57,886		$ 57,886
Conversion Rate (in dollars per share) | $ / shares	[3]	$ 3.30		$ 3.30
Shares Underlying Principal | Number	[3]	69,616		68,122
Yutaka & Soomi Niihara [Member]
Short-term Debt [Line Items]
Interest Rate	[3]	10.00%		10.00%	[2]
Date of Loan	[3]	Nov. 16, 2015		Nov. 16, 2015	[2]
Term of Loans	[3]	2 years		2 years	[2]
Principal Amount Outstanding	[3]	$ 200,000		$ 200,000	[2]
Highest Principal Outstanding	[3]	$ 200,000		$ 200,000	[2]
Conversion Rate (in dollars per share) | $ / shares	[3]	$ 4.50		$ 4.50	[2]
Shares Underlying Principal | Number	[3]	55,001		53,905	[2]
Convertible notes payable - related party [Member]
Short-term Debt [Line Items]
Term of Loans	[2],[3]	2 years
Principal Amount Outstanding		$ 400,000	[2],[3]	$ 400,000
Highest Principal Outstanding		608,800	[2],[3]	608,800
Amount of Principal Repaid		208,800	[2],[3]	208,800
Amount of Interest Paid		$ 62,291	[2],[3]	$ 62,291
Shares Underlying Principal | Number		124,617	[2],[3]	122,027
Promissory note payable and convertible notes payable - related party [Member]
Short-term Debt [Line Items]
Principal Amount Outstanding		$ 2,444,973		$ 2,436,261
Highest Principal Outstanding		4,179,878		4,171,166
Amount of Principal Repaid		1,003,139		1,003,139
Amount of Interest Paid		$ 191,761		$ 191,761
Shares Underlying Principal | Number		124,617		122,027
Hope Hospice [Member]
Short-term Debt [Line Items]
Interest Rate	[1]			8.00%
Date of Loan	[1]			Jan. 17, 2012
Highest Principal Outstanding	[1]			$ 200,000
Amount of Principal Repaid	[1]			200,000
Amount of Interest Paid	[1]			$ 7,331
Hope Hospice [Member]
Short-term Debt [Line Items]
Interest Rate	[1]			8.00%
Date of Loan	[1]			Jun. 14, 2012
Highest Principal Outstanding	[1]			$ 200,000
Amount of Principal Repaid	[1]			200,000
Amount of Interest Paid	[1]			$ 14,762
Hope Hospice [Member]
Short-term Debt [Line Items]
Interest Rate	[1]			8.00%
Date of Loan	[1]			Jun. 21, 2012
Highest Principal Outstanding	[1]			$ 100,000
Amount of Principal Repaid	[1]			100,000
Amount of Interest Paid	[1]			$ 7,249
Hope Hospice [Member]
Short-term Debt [Line Items]
Interest Rate	[1]			8.00%
Date of Loan	[1]			Feb. 11, 2013
Highest Principal Outstanding	[1]			$ 50,000
Amount of Principal Repaid	[1]			50,000
Amount of Interest Paid	[1]			$ 1,559
Hope Hospice [Member]
Short-term Debt [Line Items]
Interest Rate	[1]			10.00%
Date of Loan	[1]			Jan. 7, 2015
Highest Principal Outstanding	[1]			$ 100,000
Amount of Principal Repaid	[1]			100,000
Amount of Interest Paid	[1]			$ 28,630
IRA Service Trust Co. FBO Peter B. Ludlum [Member]
Short-term Debt [Line Items]
Interest Rate	[3]			10.00%
Date of Loan	[3]			Feb. 20, 2015
Principal Amount Outstanding	[3]			$ 10,000
Highest Principal Outstanding	[3]			$ 10,000
Yutaka Niihara [Member]
Short-term Debt [Line Items]
Interest Rate				10.00%
Date of Loan				May 21, 2015
Highest Principal Outstanding				$ 826,105
Amount of Principal Repaid				94,339
Amount of Interest Paid				$ 61,829
IRA Service Trust Co. FBO Peter B. Ludlum Member]
Short-term Debt [Line Items]
Interest Rate	[3]			10.00%
Date of Loan	[3]			May 5, 2016
Principal Amount Outstanding	[3]			$ 10,000
Highest Principal Outstanding	[3]			$ 10,000
Hope Hospice [Member]
Short-term Debt [Line Items]
Interest Rate	[1]			10.00%
Date of Loan	[1]			Jun. 3, 2016
Principal Amount Outstanding	[1]			$ 250,000
Highest Principal Outstanding	[1]			$ 250,000
Charles & Kimxa Stark [Member]
Short-term Debt [Line Items]
Interest Rate	[3]			10.00%
Date of Loan	[3]			Oct. 1, 2015
Term of Loans	[3]			2 years
Highest Principal Outstanding	[3]			$ 20,000
Amount of Principal Repaid	[3]			20,000
Amount of Interest Paid	[3]			$ 4,405
Conversion Rate (in dollars per share) | $ / shares	[3]			$ 4.50
[1]	Dr. Niihara, a director and officer of the Company, is also the Chief Executive Officer of Hope Hospice.
[2]	Director.
[3]	Officer.

GEOGRAPHIC INFORMATION (Details

GEOGRAPHIC INFORMATION (Details) - USD ($)	3 Months Ended
	Mar. 31, 2018	Mar. 31, 2017
United States [Member]
Entity Wide Revenue Major Customer [Line Items]
Revenue	$ 675,046	$ 14,619
Percentage of revenue (in percent)	86.00%	13.00%
Japan [Member]
Entity Wide Revenue Major Customer [Line Items]
Revenue	$ 43,005	$ 28,558
Percentage of revenue (in percent)	6.00%	27.00%
Taiwan [Member]
Entity Wide Revenue Major Customer [Line Items]
Revenue	$ 26,100	$ 64,300
Percentage of revenue (in percent)	3.00%	60.00%
France [Member]
Entity Wide Revenue Major Customer [Line Items]
Revenue	$ 37,162
Percentage of revenue (in percent)	5.00%

SUBSEQUENT EVENTS (Details)

SUBSEQUENT EVENTS (Details) - USD ($)	Apr. 01, 2018	Mar. 31, 2018
Principal Amounts		$ 52,625,294
Convertible Notes Payable [Member] | Subsequent Event [Member]
Principal Amounts	$ 250,000
Stated Annual Interest	10.00%
Term of Notes	2 Years
Conversion Price	$ 10

SUBSEQUENT EVENTS (Details 1)

SUBSEQUENT EVENTS (Details 1) - USD ($)	Apr. 01, 2018	Mar. 31, 2018
Common shares		$ 275,000
Common Stock [Member]
Common shares		$ 25
Number of Shares Issued		25,000
Common Stock [Member] | Subsequent Event [Member]
Number of Shares Issued	8,316