Aadi Bioscience (AADI) 10-K 28 Mar 23 2022 FY Annual report Financial data

Cover Page

Cover Page - USD ($)	12 Months Ended
	Dec. 31, 2022	Mar. 23, 2023	Jun. 30, 2022
Cover [Abstract]
Document Type	10-K
Document Annual Report	true
Document Period End Date	Dec. 31, 2022
Current Fiscal Year End Date	--12-31
Document Transition Report	false
Entity File Number	001-38560
Entity Registrant Name	AADI BIOSCIENCE, INC.
Entity Incorporation, State or Country Code	DE
Entity Tax Identification Number	61-1547850
Entity Address, Address Line One	17383 Sunset Boulevard
Entity Address, Address Line Two	Suite A250
Entity Address, City or Town	Pacific Palisades
Entity Address, State or Province	CA
Entity Address, Postal Zip Code	90272
City Area Code	424
Local Phone Number	744-8055
Title of 12(b) Security	Common stock, $0.0001 par value per share
Trading Symbol	AADI
Security Exchange Name	NASDAQ
Entity Well Known Seasoned Issuer	No
Entity Voluntary Filers	No
Entity Current Reporting Status	Yes
Entity Interactive Data Current	Yes
Entity Filer Category	Non-accelerated Filer
Entity Emerging Growth Company	false
Entity Small Business	true
ICFR Auditor Attestation Flag	false
Entity Shell Company	false
Entity Public Float			$ 177,896,069
Entity Common Stock, Shares Outstanding		24,436,990
Documents Incorporated by Reference	DOCUMENTS INCORPORATED BY REFERENCE Portions of the Registrant’s definitive Proxy Statement relating to its 2023 Annual Meeting of Stockholders to be filed with the Securities and Exchange Commission pursuant to Regulation 14A not later than 120 days after the end of the fiscal year covered by this Annual Report on Form 10-K are incorporated herein by reference in Part III of this Annual Report on Form 10-K where indicated.
Amendment Flag	false
Document Fiscal Year Focus	2022
Document Fiscal Period Focus	FY
Entity Central Index Key	0001422142

Audit Information

Audit Information	12 Months Ended
	Dec. 31, 2022
Auditor Information [Abstract]
Auditor Name	BDO USA, LLP
Auditor Location	San Diego, California
Auditor Firm ID	243

Consolidated Balance Sheets

Consolidated Balance Sheets - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Current assets:
Cash and cash equivalents	$ 39,019	$ 148,989
Short-term investments	133,541	0
Accounts receivable, net	1,862	0
Inventory	1,861	0
Prepaid expenses and other current assets	3,746	2,283
Total current assets	180,029	151,272
Property and equipment, net	508	57
Operating lease right-of-use assets	1,522	557
Intangible asset, net	0	3,811
Other assets	2,178	2,213
Total assets	184,237	157,910
Current liabilities:
Accounts payable	3,519	6,439
Accrued liabilities	14,922	8,703
Operating lease liabilities, current portion	394	131
Total current liabilities	18,835	15,273
Operating lease liabilities, net of current portion	1,267	474
Due to licensor	5,757	5,757
Total liabilities	25,859	21,504
Commitments and contingencies
Preferred stock, shares issued (in shares)	0	0
Stockholders’ equity:
Preferred stock, $0.0001 par value, 10,000,000 shares authorized; no shares issued and outstanding as of December 31, 2022 and 2021	$ 0	$ 0
Common stock, $0.0001 par value, 300,000,000 shares authorized; 24,435,007 and 20,894,695 shares issued and outstanding as of December 31, 2022 and 2021, respectively	2	2
Additional paid-in capital	361,689	279,089
Accumulated other comprehensive loss	(115)	0
Accumulated deficit	(203,198)	(142,685)
Total stockholders’ equity	158,378	136,406
Total liabilities and stockholders’ equity	$ 184,237	$ 157,910

Consolidated Balance Sheets (Pa

Consolidated Balance Sheets (Parenthetical) - $ / shares	Dec. 31, 2022	Dec. 31, 2021
Statement of Financial Position [Abstract]
Preferred stock, par value (in dollars per share)	$ 0.0001	$ 0.0001
Preferred stock, shares authorized (in shares)	10,000,000	10,000,000
Preferred stock, shares issued (in shares)	0	0
Preferred stock, shares outstanding (in shares)	0	0
Common stock, par value (in dollars per share)	$ 0.0001	$ 0.0001
Common stock, shares authorized (in shares)	300,000,000	300,000,000
Common stock, shares issued (in shares)	24,435,007	20,894,695
Common stock, shares outstanding (in shares)	24,435,007	20,894,695

Consolidated Statements of Oper

Consolidated Statements of Operations - USD ($)	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Total revenue	$ 15,216,000	$ 1,120,000
Operating expenses
Selling, general and administrative	40,176,000	18,511,000
Research and development	32,662,000	19,670,000
Cost of goods sold	1,335,000	0
Impairment of acquired contract intangible asset	3,724,000	74,156,000
Total operating expenses	77,897,000	112,337,000
Loss from operations	(62,681,000)	(111,217,000)
Other income (expense)
Change in fair value of convertible promissory notes	0	1,585,000
Gain upon extinguishment of debt	0	196,000
Interest income	2,398,000	13,000
Interest expense	(230,000)	(665,000)
Total other income, net	2,168,000	1,129,000
Loss before income tax expense	(60,513,000)	(110,088,000)
Income tax expense	0	(2,000)
Net loss	(60,513,000)	(110,090,000)
Cumulative dividends on convertible preferred stock	0	(647,000)
Net loss attributable to common shareholders, basic	(60,513,000)	(110,737,000)
Net loss attributable to common shareholders, diluted	$ (60,513,000)	$ (110,737,000)
Net loss per share attributable to common stockholders, basic (in dollars per share)	$ (2.69)	$ (12.41)
Net loss per share attributable to common stockholders, diluted (in dollars per share)	$ (2.69)	$ (12.41)
Weighted average number of common shares outstanding used in computing net loss per share attributable to common stockholders, basic (in shares)	22,511,237	8,923,369
Weighted average number of common shares outstanding used in computing net loss per share attributable to common stockholders, diluted (in shares)	22,511,237	8,923,369
Product sales, net
Total revenue	$ 15,216,000	$ 0
License revenue
Total revenue	0	1,000,000
Grant revenue
Total revenue	$ 0	$ 120,000

Consolidated Statements of Comp

Consolidated Statements of Comprehensive Loss - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Statement of Comprehensive Income [Abstract]
Net loss	$ (60,513)	$ (110,090)
Change in unrealized loss on short-term investments	(115)	0
Comprehensive loss	$ (60,628)	$ (110,090)

Consolidated Statements of Stoc

Consolidated Statements of Stockholders' Equity (Deficit) - USD ($) $ in Thousands	Total	Promissory Note	PIPE Investors	Former Stockholders of Aerpio Upon Merger	Preferred Stock Series Seed Preferred Stock	Preferred Stock Series A Preferred Stock	Common Stock	Common Stock Promissory Note	Common Stock PIPE Investors	Common Stock Former Stockholders of Aerpio Upon Merger	Additional Paid-In Capital	Additional Paid-In Capital Promissory Note	Additional Paid-In Capital PIPE Investors	Additional Paid-In Capital Former Stockholders of Aerpio Upon Merger	Accumulated Other Comprehensive Loss	Accumulated Deficit
Balance (in shares) at Dec. 31, 2020	$ (12,432)					$ 1	$ 1				$ 20,161				$ 0	$ (32,595)
Balance at Dec. 31, 2020					734,000	7,212,000	2,542,000
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock upon exercise of stock options (in shares)							73,000
Issuance of common stock upon exercise of stock options	833										833
Issuance of common stock (in shares)									11,853,000	3,209,000
Issuance of common stock			$ 145,384	$ 105,888					$ 1				$ 145,383	$ 105,888
Conversion of convertible promissory note/preferred stock in to common stock upon merger (in shares)					(734,000)	(7,212,000)	2,520,000	698,000
Conversion of convertible promissory note/preferred stock in to common stock upon merger	(1)	$ 9,130				$ (1)						$ 9,130
Share-based compensation expense	2,106										2,106
Cumulative dividends paid on Series A preferred stock	(4,412)										(4,412)
Net loss	(110,090)															(110,090)
Balance (in shares) at Dec. 31, 2021	$ 136,406					$ 0	$ 2				279,089				0	(142,685)
Balance at Dec. 31, 2021					0	0	20,895,000
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock upon exercise of stock options (in shares)	132,084						132,000
Issuance of common stock upon exercise of stock options	$ 401										401
Issuance of common stock upon exercise of warrants (in shares)							7,000
Issuance of common stock upon exercise of warrants	55										55
Issuance of common stock (in shares)									3,374,000
Issuance of common stock			$ 72,178										$ 72,178
Share-based compensation expense	9,643										9,643
Issuance of shares under the employee stock purchase plan (in shares)							27,000
Issuance of shares under the employee stock purchase plan	323										323
Other comprehensive loss	(115)														(115)
Net loss	(60,513)															(60,513)
Balance (in shares) at Dec. 31, 2022	$ 158,378					$ 0	$ 2				$ 361,689				$ (115)	$ (203,198)
Balance at Dec. 31, 2022					0	0	24,435,000

Consolidated Statements of Cash

Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Cash flows from operating activities:
Net loss	$ (60,513)	$ (110,090)
Adjustments to reconcile net loss to net cash used in operating activities:
Impairment of acquired contract intangible asset	3,724	74,156
Share-based compensation expense	9,643	2,106
Amortization of premiums and discounts on short-term investments, net	(1,215)	0
Change in fair value of convertible promissory notes	0	(1,585)
Non-cash interest expense	0	665
Gain upon extinguishment of debt	0	(196)
Non-cash lease expense	382	171
Depreciation and amortization expense	159	105
Changes in operating assets and liabilities:
Accounts receivable	(1,862)	14,149
Inventory	(1,861)	0
Prepaid expenses and other current assets	(1,463)	(2,166)
Other non-current assets	437	481
Operating lease liabilities, net	(291)	(129)
Accounts payable and accrued liabilities	3,220	8,290
Other liabilities	0	(8,380)
Net cash used in operating activities	(49,640)	(22,423)
Investing activities:
Purchases of property and equipment	(444)	(46)
Purchases of short-term investments	(145,192)	0
Maturities of short-term investments	12,750	0
Cash acquired in connection with the Merger	0	29,700
Transaction expenses related to the Merger	0	(4,501)
Net cash (used in) provided by investing activities	(132,886)	25,153
Financing activities:
Proceeds from issuance of common stock and prefunded warrants to PIPE Investors	72,500	0
Issuance of common stock upon exercise of stock options	401	833
Proceeds from issuance under employee stock purchase plan	323	0
Issuance of common stock upon exercise of warrants	55	0
Deferred offering costs paid for financing	(337)	0
Costs incurred in connection with issuance of common stock	(322)	(9,617)
Proceeds from the issuance of common stock to PIPE Investors	0	155,000
Dividends paid	0	(4,412)
Net cash provided by financing activities	72,620	141,804
Net (decrease) increase in cash, cash equivalents and restricted cash	(109,906)	144,534
Cash, cash equivalents and restricted cash at beginning of year	148,989	4,455
Cash, cash equivalents and restricted cash at end of year	39,083	148,989
Supplemental disclosure of cash flow information:
Interest paid during the period	230	22
Costs incurred in connection with issuance of common stock paid during the period	322	0
Supplemental disclosure of non-cash activities:
Issuance of common stock upon Merger	0	105,888
Conversion of convertible promissory note into common stock upon Merger	0	9,130
Amounts accrued for purchases of property and equipment	80	0
Right-of-use assets obtained in exchange for operating lease liabilities	$ 1,241	$ 610

Nature of Organization and Oper

Nature of Organization and Operations	12 Months Ended
	Dec. 31, 2022
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Nature of Organization and Operations	Nature of Organization and Operations Aadi Bioscience, Inc. (together with its subsidiaries, the “Company” or “Aadi”) is a biopharmaceutical company focused on developing and commercializing precision therapies for genetically defined cancers with alterations in mTOR pathway genes. Aadi’s lead drug product, FYARRO ® , is a form of sirolimus bound to albumin. Sirolimus is a potent inhibitor of the mTOR biological pathway, the activation of which pathway can promote tumor growth, and inhibits downstream signaling from mTOR. In November 2021, the U.S. Food and Drug Administration (the “FDA”) approved FYARRO sirolimus protein-bound particles for injectable suspension (albumin-bound) for the treatment of adult patients with locally advanced unresectable or metastatic malignant perivascular epithelioid cell tumor (“PEComa”). On February 22, 2022, Aadi launched FYARRO in the United States for treatment of advanced malignant PEComa. FYARRO is licensed to Aadi by Abraxis BioScience, LLC, a wholly owned subsidiary of Celgene Corporation. The Company’s historical operations have consisted principally of performing research and development activities and raising capital. The Company’s activities are subject to significant risks and uncertainties, including failing to secure additional funding before sustainable revenues and profit from operations are achieved. Merger with Aerpio Pharmaceuticals, Inc. and Name Change On May 16, 2021, the Company, then operating as Aerpio Pharmaceuticals, Inc. (“Aerpio”), entered into the Agreement and Plan of Merger (“Merger Agreement”) with Aspen Merger Subsidiary, Inc., a Delaware corporation and a direct, wholly owned subsidiary of Aerpio (“Merger Sub”) and Aadi Subsidiary, Inc. (formerly known as Aadi Bioscience, Inc. (“Private Aadi”)). Pursuant to the terms set forth in the Merger Agreement and effective August 26, 2021 (the “Effective Time”): (i) Merger Sub merged with and into Private Aadi, with Private Aadi surviving as a wholly owned subsidiary of Aerpio (the “Merger”), (ii) Aerpio changed its name to Aadi Bioscience, Inc. in connection with and immediately prior to the Effective Time, and (iii) Aerpio effected a 15:1 reverse stock split of the Aerpio common stock (“Reverse Stock Split”) immediately prior to the Effective Time. At the Effective Time, each share of Private Aadi common stock outstanding immediately prior to the Effective Time, including the shares of Private Aadi common stock issuable upon the conversion of all shares of preferred stock and convertible promissory notes immediately prior to the closing of the Merger, were converted into the right to receive shares of the Company’s common stock based on an exchange ratio of 0.3172 (the “Exchange Ratio”), after taking into account the Reverse Stock Split. Pursuant to the Merger Agreement, Aerpio assumed all of the outstanding and unexercised options to purchase shares of Private Aadi capital stock under the Private Aadi Amended and Restated 2014 Equity Incentive Plan (the “Private Aadi Plan”), and, in connection with the Merger, such options were converted into options to purchase shares of the Company’s common stock based on the Exchange Ratio. At the closing of the Merger at the Effective Time, the Company issued an aggregate of 5,776,660 shares of common stock to holders of Private Aadi common stock, including in respect of shares of Private Aadi common stock issued upon the conversion of all shares of preferred stock and convertible promissory notes outstanding immediately prior to the Effective Time. The Merger has been accounted for using the reverse asset acquisition method under U.S. generally accepted accounting principles (“GAAP”). For accounting purposes, Private Aadi is considered to have acquired the Company and the Merger has been accounted for as a reverse asset acquisition. The estimated fair value of total consideration given was $110.4 million based on 3,208,718 shares of common stock at $33.00 per share, after taking into account the Reverse Stock Split, outstanding immediately prior to the Effective Time, plus Private Aadi’s transaction costs. Private Aadi is considered the accounting acquirer even though the Company issued the common stock in the Merger based on the terms of the Merger Agreement and other factors including: (i) following the Merger, the stockholders of Private Aadi collectively owned a substantial portion of the voting rights of the Company; (ii) three (3) of seven (7) members of the board of directors of the Company post-Merger were composed of directors designated by Private Aadi under the terms of the Merger Agreement, and one (1) member of the board of directors of the Company post-Merger was a director mutually designated by Private Aadi and Aerpio; (iii) existing members of Private Aadi’s management became the management of the Company post-Merger; (iv) the 2021 Private Investment in Public Equity (PIPE) Investors (as defined below) consist of individuals and funds, and for purpose of this analysis, as of immediately following the Merger (and after giving effect to the 2021 PIPE Financing), no one individual or fund held more shares than the holders of Private Aadi collectively owned immediately following the Merger and they are not considered to be a single voting group; and (v) following the Merger, the Company is named “Aadi Bioscience, Inc.” and headquartered in Pacific Palisades, California, and all ongoing operations of the Company are those of Private Aadi. To determine the accounting for this transaction under GAAP, a company must assess whether an integrated set of assets and activities should be accounted for as an acquisition of a business or an asset acquisition. Upon closing of the Merger, substantially all of the fair value is concentrated in cash, working capital and a long-lived contract intangible asset. As such, the acquisition was treated as an asset acquisition. The net assets of Aerpio have been recorded at their relative fair value in the consolidated financial statements of the Company and the reported operating results prior to the Merger will be those of Private Aadi. In connection with the closing of the Merger, Private Aadi’s board of directors declared a 4% cumulative dividend on its preferred stock of $4.4 million which was paid at the Effective Time. Contingent Value Rights and Contingent Value Rights Agreement In connection with the Merger, the Company entered into a Contingent Value Rights Agreement, dated as of August 26, 2021 (the “CVR Agreement”), with a legacy director of the Company, as Holder Representative (as defined in the CVR Agreement), and American Stock Transfer & Trust Company, LLC, as Rights Agent (as defined in the CVR Agreement), in accordance with the terms of the Merger Agreement. The CVR Agreement entitled each holder of Aerpio common stock as of immediately prior to the closing of the Merger (each, a “CVR Holder”) to receive one contingent value right (“CVR”) for each outstanding share of the Company common stock held by such CVR Holder as of immediately prior to the closing of the Merger, each representing the right to receive certain net proceeds, if any, derived from the CVR completed during a CVR Payment Period, which means successive six-month periods, prior to the expiration of the CVR Term (as defined in the CVR Agreement), with any potential payment obligations continuing until the earlier of (a) the 20-year anniversary of the Effective Time and (b) the time at which the license agreement dated June 24, 2018, as amended (the “Gossamer License Agreement”) with Gossamer Bio, Inc. (“Gossamer”), the underlying basis for the CVR, has expired or been terminated. On April 25, 2022, the Company received a formal notice of termination from Gossamer for the Gossamer License Agreement (the “Notice of Termination”), that related to Gossamer’s GB004 product candidate, a legacy product candidate of the Company's predecessor, Aerpio, after Gossamer announced that its Phase 2 SHIFT-UC clinical trial studying GB004 in patients with mild-to-moderate active ulcerative colitis did not meet the primary or secondary endpoints at week 12 and the study was being terminated for lack of treatment benefit. The Gossamer License Agreement terminated effective July 24, 2022. Based on the Notice of Termination, the Company fully impaired the Gossamer License Agreement intangible asset during the year ended December 31, 2022. In connection with the termination of the Gossamer License Agreement, the CVR Agreement automatically terminated in accordance with its terms and the CVRs were automatically cancelled and forfeited without any consideration or payment, in each case effective July 24, 2022. 2021 Private Investment in Public Equity (PIPE) Financing and Subscription Agreement On May 16, 2021, the Company entered into a subscription agreement (“Subscription Agreement”) with certain investors (the “2021 PIPE Investors”), pursuant to which it would sell shares of its Common Stock concurrently with the closing of the Merger (the “2021 PIPE Financing”). The 2021 PIPE Investors purchased an aggregate of 11,852,862 shares of common stock of the Company (the “2021 PIPE Shares”) for an aggregate purchase price of $155.0 million pursuant to the Subscription Agreement. The aggregate net proceeds for the issuance and sale of the 2021 PIPE Shares were $145.4 million, after deducting certain expenses incurred that were direct and incremental to the issuance of the 2021 PIPE Shares. At the closing of the 2021 PIPE Financing, the Company entered into a Registration Rights Agreement, dated August 26, 2021 (“Registration Rights Agreement”), with the 2021 PIPE Investors. Immediately following the Effective Time, and after giving effect to the Reverse Stock Split and the 2021 PIPE Financing, there were approximately 20.8 million shares of common stock of the Company outstanding. Immediately following the Effective Time and after giving effect to the Reverse Stock Split and the 2021 PIPE Financing: (i) the Private Aadi stockholders owned approximately 29.2% of the outstanding shares of common stock; (ii) Aerpio’s stockholders immediately prior to the Merger, whose shares of common stock, as adjusted for the Reverse Stock Split, remain outstanding after the Merger, owned approximately 15.2% of the outstanding shares of common stock; and (iii) the 2021 PIPE Investors owned approximately 55.6% of the outstanding shares of common stock, in each case as calculated on a fully-diluted basis. 2022 Private Investment in Public Equity (PIPE) Financing On September 22, 2022, the Company entered into a securities purchase agreement (“Purchase Agreement”) with certain investors (“2022 PIPE Investors”) for a private placement of shares of common stock and pre-funded warrants to purchase shares of common stock (the “2022 PIPE Financing”). Upon the closing of the 2022 PIPE Financing on September 26, 2022, the Company sold (i) 3,373,526 shares of its common stock at a purchase price of $12.50 per share, and (ii) 2,426,493 pre-funded warrants (the “Pre-Funded Warrants”) to purchase shares of common stock at a purchase price of $12.4999 per pre-funded warrant. The Pre-Funded Warrants have an exercise price of $0.0001 per share of common stock, are immediately exercisable and remain exercisable until exercised in full. The holders of Pre-Funded Warrants may not exercise a Pre-Funded Warrant if the holder, together with its affiliates, would beneficially own more than 4.99% of the number of shares of the Company's common stock outstanding immediately after giving effect to such exercise; provided, that the holders of Pre-Funded Warrants may increase or decrease such percentages not in excess of 19.99% by providing at least 61 days’ prior notice to the Company. The aggregate net proceeds for the 2022 PIPE Financing were $72.2 million after deducting certain expenses incurred that were direct and incremental to the issuance of the shares of $0.3 million. On September 26, 2022, the Company and the 2022 PIPE Investors entered into a Registration Rights Agreement, (the “2022 PIPE Registration Rights Agreement”), providing for the registration for resale of the securities sold under the Purchase Agreement, including the shares issuable upon the exercise of the Pre-Funded Warrants, that are not then registered on an effective registration statement, pursuant to a registration statement filed with the Securities and Exchange Commission (the “SEC”). The Company has granted the 2022 PIPE Investors customary indemnification rights in connection with the 2022 PIPE Registration Rights Agreement. The Purchasers have also granted the Company customary indemnification rights in connection with the 2022 PIPE Registration Rights Agreement. Liquidity Since inception, the Company has devoted substantially all of its resources to research and development activities, business planning, establishing and maintaining its intellectual property portfolio, hiring personnel, raising capital and providing general and administrative support for these operations and has only recently begun to realize revenues from its planned principal operations commencing with the commercial sale of FYARRO. The Company has experienced net losses since its inception and expects to continue to incur net losses into the foreseeable future. The Company had an accumulated deficit of $203.2 million as of December 31, 2022 and a net loss of $60.5 million and $110.1 million for the years ended December 31, 2022 and 2021, respectively. T o date, these operating losses have been funded primarily from outside sources of invested capital through the issuance of convertible promissory notes, grant funding, the sale of securities, and proceeds from license agreements. The Company had cash, cash equivalents and short term investments of $172.6 million at December 31, 2022. Management believes the Company’s current cash, cash equivalents and short-term investments will provide sufficient funds to enable the Company to meet its obligations for at least twelve months from the filing date of this report. If the Company is unable to achieve and maintain profitability, it will need additional financing to support its continuing operations and pursue its strategic objectives. Additional financing may be achieved through a combination of equity offerings, and debt financings. The Company may be unable to raise additional funds or enter into such other agreements when needed on favorable terms or at all. On March 17, 2022, the Company entered into a Sales Agreement (the “Sales Agreement”) with Cowen and Company, LLC (“Cowen”), pursuant to which the Company may offer and sell, from time to time at the Company’s sole discretion, shares of its common stock having an aggregate offering price of up to $75.0 million through Cowen as its sales agent for an at-the-marketing-offering. As of December 31, 2022, no shares of common stock had been sold under the Sales Agreement.

Summary of Significant Accounti

Summary of Significant Accounting Policies	12 Months Ended
	Dec. 31, 2022
Accounting Policies [Abstract]
Summary of Significant Accounting Policies	Summary of Significant Accounting Policies Basis of Presentation The consolidated financial statements, and the related disclosures, have been prepared in accordance with GAAP and SEC regulations and, in the opinion of management include all adjustments necessary for a fair presentation of the results of operations, financial position, changes in stockholders’ equity and cash flows for each period presented. Any reference in these notes to applicable guidance is meant to refer to the authoritative GAAP as found in the Accounting Standards Codification (“ASC”) and Accounting Standards Updates (“ASU”) of the Financial Accounting Standards Board (“FASB”). All adjustments are of a normal recurring nature. The Company’s consolidated financial statements are stated in U.S. dollars. Certain prior year amounts have been reclassified to conform to the current year presentation. On August 26, 2021, when the Company closed the Merger, all outstanding shares of common stock along with preferred stock of Private Aadi were exchanged for new shares of common stock of the Company and the approximately 8.1 million shares of Private Aadi capital stock held by stockholders of Private Aadi immediately prior to the Merger were exchanged for approximately 2.5 million shares of common stock of the Company based on the Exchange Ratio. The authorized number of shares of common stock was not reduced and remains at 300.0 million. The par value of the Company’s common stock remains unchanged at $0.0001 per share. Also on August 26, 2021, and immediately prior to the closing of the Merger, the Company effected the Reverse Stock Split. Accordingly, all share and per share amounts for the period presented in the accompanying consolidated financial statements and notes thereto have been adjusted retroactively, where applicable, to reflect the Reverse Stock Split. No fractional shares were issued in connection with the Reverse Stock Split. Unless otherwise noted, all references to shares of the Company’s common stock and per share amounts have also been adjusted to reflect the Exchange Ratio. Comprehensive Loss Comprehensive loss is defined as the change in equity during a period from transactions and other events and circumstances from non-owner sources, including unrealized gains and losses on short-term investments. Comprehensive loss has been reflected in the statements of operations and comprehensive loss for all periods presented. Segment Information Operating segments are defined as components of an enterprise about which separate discrete information is available for evaluation by the chief operating decision maker, or decision-making group, in deciding how to allocate resources and in assessing performance. The Company has identified its Chief Executive Officer as the chief operating decision maker and the Company views its operations and manages its business in one operating segment, which is the business of developing and commercializing proprietary therapeutics. All the assets and operations of the Company’s sole operating and reportable segment are located in the United States. Use of Estimates The preparation of financial statements in conformity with GAAP requires management to make estimates and assumptions that impact the reported amounts of assets, liabilities, revenues and expenses, and the disclosure of contingent assets and liabilities in the Company’s consolidated financial statements and accompanying notes. In the opinion of management, all adjustments that are considered necessary for fair presentation have been included. The most significant estimates in the Company’s consolidated financial statements relate to fair value of the intangible asset, fair value of the convertible promissory notes, gross-to-net accruals, share-based compensation expense and accrued research and development costs. Although these estimates are based on the Company’s knowledge of current events and actions it may undertake in the future, actual results may materially differ from these estimates and assumptions. Concentrat ion of Credit Risk Financial instruments, which potentially subject the Company to concentration of credit risk, consist primarily of cash and cash equivalents, and investments in money market funds, United States government treasury bills, commercial paper, corporate bonds, and government agency debt securities. The Company maintains deposits in federally insured financial institutions in excess of federally insured limits. Management believes that the Company is not exposed to significant credit risk due to the financial position of the depository institutions in which those deposits are held. While the Company has not experienced any losses in such deposits, the recent failure of Silicon Valley Bank, at which the Company holds cash and cash equivalents in multiple accounts, exposed the Company to credit risk prior to the resolution by the Federal Deposit Insurance Corporation in a manner that fully protected all depositors. The Company has not experienced any losses on deposits since inception. The Company’s accounts receivable is derived from customers located principally in the United States. The Company performs ongoing credit evaluations of its customers and maintains allowances for potential credit losses on customers’ accounts when deemed necessary. The Company does not typically require collateral from its customers. Credit losses historically have not been material. The Company continuously monitors customer payments and maintains an allowance for doubtful accounts based on its assessment of various factors including historical experience, age of the receivable balances, and other current economic conditions or other factors that may affect customers’ ability to pay. Customer Concentration The majority of the Company's revenue for the year ended December 31, 2022 was from two companies at 58% and 41% of the Company’s revenue, respectively. Additionally, one customer accounted for 100% of the net accounts receivable as of December 31, 2022 . Cash, Cash Equivalents and Restricted Cash The Company considers all highly liquid marketable securities purchased with original maturities of three months or less at the time of purchase date to be cash equivalents. As of December 31, 2022 and 2021, cash and cash equivalents included money market investments totaling $32.0 million and $140.0 million, respectively. Restricted cash consists of a letter of credit secured by restricted cash in connection with one of the Company's office leases described in Note 8, and is included in other assets on the consolidated balance sheet. The following table provides a reconciliation of cash, cash equivalents and restricted cash reported within the consolidated statements of cash flows (amounts in thousands): As of December 31, 2022 2021 Cash and cash equivalents $ 39,019 $ 148,989 Restricted cash, non-current 64 — Total cash, cash equivalents and restricted cash $ 39,083 $ 148,989 Fair Value Option The Company elected the fair value option to account for its convertible promissory notes which were issued in 2019 and 2020. The Company recorded the convertible promissory notes at fair value with changes in fair value recorded in the statements of operations. As of December 31, 2022 and 2021, there were no convertible notes outstanding as they were converted to shares of Private Aadi common stock immediately prior to the closing of the Merger. Fair Value of Financial Instruments The accounting guidance defines fair value, establishes a consistent framework for measuring fair value, and expands disclosure for each major asset and liability category measured at fair value on either a recurring or nonrecurring basis. Fair value is defined as an exit price representing the amount that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants. As such, fair value is a market-based measurement that should be determined based on assumptions that market participants would use in pricing an asset or liability. As a basis for considering such assumptions, the accounting guidance establishes a three-tier fair value hierarchy, which prioritizes the inputs used in measuring fair value as follows: Level 1: Observable inputs, such as quoted prices in active markets Level 2: Inputs, other than the quoted prices in active markets that are observable either directly or indirectly Level 3: Unobservable inputs in which there is little or no market data, which require the reporting entity to develop its own assumptions which reflect those that a market participant would use Financial assets and liabilities are classified in their entirety based on the lowest level of input that is significant to the fair value measurement. The Company’s assessment of the significance of a particular input to the fair value measurement requires judgment and may affect the valuation of fair value assets and liabilities and their placement within the fair value hierarchy levels. In determining the fair value of its financial instruments, the Company considers the source of observable market data inputs, liquidity of the instrument, the credit risk of the counterparty to the contract, and its risk of nonperformance. In the case fair value is not observable, for the items subject to fair value measurements, the Company applies valuation techniques deemed the most appropriate under the GAAP guidance based on the nature of the assets and liabilities being measured. The carrying amounts of cash and cash equivalents, accounts receivable, prepaid expenses and other current assets and accounts payable are reasonable estimates of their fair value because of the short maturity of these items. Short-term investments The Company invests in various types of securities, including United States government and commercial paper and corporate debt securities. The Company classifies its investments as available-for-sale and records them at fair value based upon market prices at period end. Unrealized gains and losses that are deemed temporary in nature are recorded in accumulated other comprehensive loss as a separate component of stockholders’ equity. Dividend and interest income are recognized when earned. Realized gains and losses are included in earnings and are derived using the specific identification method for determining the cost of investments sold. The Company classifies short-term investments wi th remaining maturities greater than one year as current assets because such short-term investments are available to fund the Company’s current operations. At each balance sheet date, the Company assesses available-for-sale securities in an unrealized loss position to determine whether the unrealized loss is other-than-temporary. When the Company determines that a decline in the fair value below its cost basis is other-than-temporary, the Company recognizes an impairment loss in the period in which the other-than-temporary decline occurred. There have been no other-than-temporary impairments recognized during any of the periods presented. See Note 4 for further informatio n. Accounts Receivable, Net Accounts receivable are recorded net of customer allowances for chargebacks and allowance for doubtful accounts. Allowance for chargebacks is based on contractual terms. The Company estimates the allowance for doubtful accounts based on existing contractual payment terms, actual payment patterns of its customers and individual customer circumstances. As of December 31, 2022, $0.1 million of customer allowances for chargebacks was recorded. No allowances were recorded as of December 31, 2021. No receivables were written off for the years ended December 31, 2022 and 2021. Inventory Inventory is stated at the lower of cost or estimated net realizable value. The Company uses actual costing methodology determined on a first-in, first-out method. The Company capitalizes inventory costs associated with its products based upon regulatory approval when, based on management’s judgment, future commercialization is considered probable and the future economic benefit is expected to be realized; otherwise, such costs are expensed. Prior to FDA approval of FYARRO, all costs related to the manufacturing of FYARRO were charged to research and development expense in the period incurred, therefore the inventory balance was zero at December 31, 2021. Details of inventory are presented as follows (amounts in thousands). As of December 31, 2022 Raw materials $ 944 Work in process — Finished goods 917 Total $ 1,861 Property and Equipment, Net Property and equipment, consisting of computers, furniture and fixtures, office equipment, construction in process and leasehold improvements are stated at cost, less accumulated depreciation. Property and equipment is depreciated using the straight-line method over the estimated useful lives of the assets, generally three Details of property and equipment are presented as follows (amounts in thousands). As of December 31, 2022 2021 Computers and software $ 338 $ 51 Construction in process 77 — Furniture and fixtures 65 36 Leasehold improvements 129 — Total $ 609 $ 87 Accumulated depreciation (101) (30) Property and equipment, net $ 508 $ 57 Intangible Asset, Net The Company’s intangible asset consisted of a single asset, the Gossamer License Agreement, assumed in the Merger. The intangible asset was stated at fair value and amortized using the straight-line method over its estimated useful life of 14.3 years. During the year ended December 31, 2021, the acquired intangible asset was reduced to its estimated fair value of $3.9 million at the Effective Time. During the year ended December 31, 2022, the intangible asset's fair value was reduced to zero based on the termination of the Gossamer License Agreement effective July 24, 2022 (see Note 6). Impairment of Long-Lived Assets The Company reviews long-lived assets, including property, equipment, and the intangible asset for impairment whenever events or changes in circumstances indicate that the carrying amount of the assets may not be recoverable. An impairment loss would be recognized when estimated undiscounted future cash flows expected to result from the use of the asset and its eventual disposition are less than the carrying amount. The impairment loss, if recognized, would be based on the excess of the carrying value of the impaired asset over its respective fair value. An impairment was recorded for the long-lived intangible asset during the year ended December 31, 2022 based on the termination of the Gossamer License Agreement effective July 24, 2022 (see Note 6). Leases At the inception of a contractual arrangement, the Company determines whether the contract contains a lease by assessing whether there is an identified asset and whether the contract conveys the right to control the use of the identified asset in exchange for consideration over a period of time. If both criteria are met, the Company records the associated lease liability and corresponding right-of-use asset upon commencement of the lease using the implicit rate or a discount rate based on a credit-adjusted secured borrowing rate commensurate with the term of the lease. The Company does not recognize assets or liabilities for leases with lease terms of less than 12 months. The Company additionally evaluates leases at their inception to determine if they are to be accounted for as an operating lease or a finance lease. A lease is accounted for as a finance lease if it meets one of the following five criteria: (i) the lease has a purchase option that is reasonably certain of being exercised, (ii) the present value of the future cash flows is substantially all of the fair market value of the underlying asset, (iii) the lease term is for a significant portion of the remaining economic life of the underlying asset, (iv) the title to the underlying asset transfers at the end of the lease term, or (v) if the underlying asset is of such a specialized nature that it is expected to have no alternative uses to the lessor at the end of the term. Leases that do not meet the finance lease criteria are accounted for as an operating lease. Operating lease assets represent a right to use an underlying asset for the lease term and operating lease liabilities represent an obligation to make lease payments arising from the lease. Operating lease liabilities with a term greater than one year and their corresponding right-of-use assets are recognized on the balance sheet at the commencement date of the lease based on the present value of lease payments over the expected lease term. Certain adjustments to the right-of-use asset may be required for items such as initial direct costs paid or incentives received. As the Company’s leases do not typically provide an implicit rate, the Company utilizes the appropriate incremental borrowing rate, determined as the rate of interest that the Company would have to pay to borrow on a collateralized basis over a similar term and in a similar economic environment. For finance leases, depreciation expense is recognized for the leased asset acquired and interest expense is recognized related to the portion of the financing in the statements of operations and comprehensive loss. For operating leases, lease cost is recognized on a straight-line basis over the lease term and variable lease payments are recognized as operating expense in the period in which the obligation for those payments is incurred. Variable lease payments primarily include common area maintenance, utilities, real estate taxes, insurance, and other operating costs that are passed on from the lessor in proportion to the space leased by the Company. The Company has elected the practical expedient to not separate between lease and non-lease components. Commitments and Contingencies The Company recognizes a liability with regard to loss contingencies when it believes it is probable a liability has been incurred, and the amount can be reasonably estimated. If some amount within a range of loss appears at the time to be a better estimate than any other amount within the range, the Company accrues that amount. When no amount within the range is a better estimate than any other amount the Company accrues the minimum amount in the range. The Company has not recorded any such liabilities as of December 31, 2022 and 2021 . Revenue Recognition and Related Allowances The Company recognizes revenue when its customer obtains control of promised goods or services, in an amount that reflects the consideration which the entity expects to receive in exchange for those goods or services. To determine revenue recognition for arrangements that the Company determines are within the scope of ASC Topic 606, Revenue from Contracts with Customers (“Topic 606”), the Company performs the following five steps: (i) identify the contract(s) with a customer; (ii) identify the performance obligations in the contract; (iii) determine the transaction price; (iv) allocate the transaction price to the performance obligations in the contract; and (v) recognize revenue when (or as) the Company satisfies a performance obligation. The Company only applies the five-step model to contracts when it is probable that it will collect the consideration it is entitled to in exchange for the goods or services it transfers to the customer. At contract inception, once the contract is determined to be within the scope of Topic 606, the Company assesses the goods or services promised within each contract and determines those that are performance obligations and assesses whether each promised good or service is distinct. The Company then recognizes as revenue the amount of the transaction price that is allocated to the respective performance obligation when (or as) the performance obligation is satisfied. Product Net Sales FYARRO was approved by the FDA in November 2021. On February 22, 2022, the Company launched sales of FYARRO to specialty distributors (“SDs”) and a specialty pharmacy (“SP”). The Company recognizes product sales when the SDs and SP obtain control of the product. Product sales are recorded at the net sales price, which includes provisions for the following allowances which are reflected either as a reduction to the related account receivable or as an accrued liability, depending on how the allowance is settled: Distribution Fees : Distribution fees include distribution service fees paid to the SDs and SP based on a contractually fixed percentage of the wholesale acquisition cost (“WAC”). Distribution fees are recorded as an offset to product sales based on contractual terms at the time revenue from the sale is recognized. Rebates : Allowance for rebates includes mandated discounts under the Medicaid Drug Rebate Program and TRICARE program. Rebates are amounts owed after the final dispensing of the product to a benefit plan participant and are based upon contractual agreements or statutory requirements. The allowance for rebates is based on contracted or statutory discount rates and expected utilization by benefit plan participants. The Company’s estimates for expected utilization of rebates are based on utilization data received from the SDs and SP since product launch. Rebates are generally invoiced and paid in arrears so that the accrual balance consists of an estimate of the amount expected to be incurred for the current quarter’s activity. If actual future rebates vary from estimates, the Company may need to adjust prior period accruals, which would affect product sales in the period of adjustment. Chargebacks: Chargebacks are discounts and fees that relate to contracts with government and other entities purchasing from the SDs and SP at a discounted price. The SDs and SP charge back to the Company the difference between the price initially paid by the SDs and SP and the discounted price paid to the SDs and SP by these entities. If actual future chargebacks vary from these estimates, the Company may need to adjust prior period accruals, which would affect product sales in the period of adjustment. Co-Payment Assistance: The Company offers co-payment assistance to commercially insured patients meeting certain eligibility requirement. Co-payment assistance is accrued at the time of product sale to SDs and SP based on estimated patient participation and average co-pay benefit to be paid per a claim. The Company estimated amounts are compared to actual program participation and co-pay amounts paid using data provided by third-party administrators. If actual amounts differ from the original estimates the assumptions being applied are updated and adjustment for prior period accruals will be adjusted in the current period. Product Returns: Consistent with industry practice, the Company offers the SDs and SP limited product return rights for damages, shipment errors, and expiring product, provided that the return is within a specified period around the product expiration date as set forth in the applicable individual distribution agreement. The Company does not allow product returns for product that has been dispensed to a patient. As the Company receives inventory reports from the SDs and SP and has the ability to control the amount of product that is sold to the SDs and SP the Company’s estimate of future potential product returns is based on the on-hand channel inventory data and sell-through data obtained from the SDs and SP. In arriving at its estimate, the Company also considers historical product returns, the underlying product demand, and industry data specific to the specialty pharmaceutical distribution industry. The total amount deducted from gross product sales for the allowances described above for the year ended December 31, 2022 was $2.4 million. The following table summarizes the consolidated activities and ending balance of all of the Company's gross-to-net sales adjustments (amounts in thousands): Balance at Beginning of Year Provision for Current Period Sales Payments Balance at End of Year Year ended December 31, 2022 $ — $ 2,438 $ (1,004) $ 1,434 Grant Revenue The Company’s grant revenues are derived from federal grants with the FDA. The Company has determined that the government agencies providing grants to the Company are not customers. Grant revenue is recognized when there is reasonable assurance of compliance with the conditions of the grant and reasonable assurance that the grant revenue will be received. The Company recognizes grant revenues as reimbursable grant costs are incurred. The costs associated with these reimbursements are reflected as a component of research and development expense in the accompanying statements of operations and comprehensive loss. With respect to grant revenue derived from reimbursement of direct out-of-pocket expenses for research costs associated with federal contracts, where the Company acts as principal with discretion to choose suppliers, bears credit risk, and performs part of the services required in the transaction, the Company records revenue for the gross amount of the reimbursement. The costs associated with these reimbursements are reflected as a component of research and development expense in the accompanying statements of operations and comprehensive loss. Revenue Under License Agreement The Company generates revenues from payments received under a license agreement. Under such license agreement, the Company recognizes revenue when it transfers promised goods or services to partners in an amount that reflects the consideration to which the Company expects to be entitled in exchange for those goods or services. To determine revenue recognition for contracts with partners, the Company performs the following five steps: (i) identifies the promised goods or services in the contract; (ii) identifies the performance obligations in the contract, including whether they are distinct in the context of the contract; (iii) determines the transaction price, including the constraint on variable consideration; (iv) allocates the transaction price to the performance obligations in the contract; and (v) recognizes revenue when (or as) the Company satisfies the performance obligations. For revenue from such license agreement, the Company generally collects an upfront license payment from the license partner and is also entitled to receive event-based payments subject to the license partner’s achievement of specified development, regulatory and sales-based milestones. In addition, the Company is generally entitled to royalties if products under the license agreement are commercialized. Transaction price for a contract represents the amount to which the Company is entitled in exchange for providing goods and services to the partner. Transaction price does not include amounts subject to uncertainties unless it is probable that there will be no significant reversal of revenue when the uncertainty is resolved. Apart from the upfront license payment, all other fees the Company may earn under such license agreements are subject to significant uncertainties of product development. Achievement of many of the event-based development and regulatory milestones may not be probable until such milestones are actually achieved. This generally relates to milestones such as obtaining regulatory approvals and successful completion of clinical trials. With respect to other development milestones, e.g., dosing of a first patient in a clinical trial, achievement could be considered probable prior to its actual occurrence, based on the progress towards commencement of the trial. The Company does not include any amounts subject to uncertainties in the transaction price until it is probable that the amount will not result in a significant reversal of revenue in the future. At the end of each reporting period, the Company re-evaluates the probability of achievement of such milestones and any related constraint, and if necessary, adjusts the estimate of the overall transaction price. Because such agreements generally only have one type of performance obligation, a license, which is generally all transferred at the same time as agreement inception, allocation of the transaction price among multiple performance obligations is not required. Upfront amounts allocated to licenses are recognized as revenue when the licenses are transferred to the partners. Development milestones and other fees are recognized in revenue when their occurrence becomes probable. Research and Development Research and development expenses consist of costs incurred in performing research and development activities, including salaries and benefits, materials and supplies, preclinical expenses, share-based compensation expense, contract services, and other external development expenses. The Company records research and development activities conducted by third-party service providers, which include work related to preclinical studies, clinical trials, and contract manufacturing activities, to research and development expense as incurred. The Company is required to estimate the amount of services provided but not yet invoiced and include these expenses in accrued expenses on the balance sheet and within research and development expenses in the statements of operations and comprehensive loss. These expenses are a significant component of the Company’s research and development expenses and require significant estimates and judgments. The Company accrues for these expenses based on factors such as estimates of the work completed and in accordance with agreements established with its third-party service providers. As actual expenses become known, the Company adjusts its accrued expenses. Share-Based Compensation The Company recognizes all share-based payments to employees, including grants of employee stock options in the consolidated statements of operations and comprehensive loss based on their fair values. All of the Company’s share-based awards, to employees, non-employees, officers, and directors, are subject only to service-based vesting conditions. The Company estimates the fair value of its share-based awards using the Black-Scholes option pricing model, which requires the input of assumptions, including (i) the expected stock price volatility, (ii) the calculation of expected term of the award, (iii) the risk-free interest rate and (iv) expected dividends. Options granted during the year have a maximum contractual term of ten years. Forfeitures are recognized and accounted for as they occur. Due to the historical lack of a public market for the trading of the Company’s securities and a lack of company-specific historical and implied volatility data, the Company has based its estimate of expected volatility on the historical volatility of a group of similar companies that are publicly traded. The computation of expected volatility is based on the historical volatility of a representative group of companies with similar characteristics to the Company, including stage of product development and life science industry focus. The Company believes the group selected has sufficient similar economic and industry characteristics and includes companies that are most representative of the Company. The Company has limited historical stock option activity and therefore estimates the expected term of stock options granted to employees, officers, and directors using the simplified method, which represents the average of the contractual term of the stock option and its weighted-average vesting period, to calculate the expected term, as it does not have sufficient historical exercise data to provide a reasonable basis upon which to estimate the expected term for options granted to employees, and utilizes the contractual term for options granted to non-employees. The expected term is applied to the stock option grant group as a whole, as the Company does not expect substantially different exercise or post-vesting termination behavior among its employee population. The risk-free interest rate is based on the U.S. Treasury yield in effect at the time of the grant for zero-coupon U.S. Treasury notes with maturities approximately equal to the expected term of the stock options. Compensation expense related to awards to employees is calculated on a straight-line basis by recognizing the grant date fair value over the associated service period of the award, which is generally the vesting term. Employee Stock Purchase Plan Stock-based compensation expense for employee stock purchases under the Company’s 2021 Employee Stock Purchase Plan (the “2021 ESPP”) is recorded at the estimated fair value of the purcha

Fair Value Measurement

Fair Value Measurement	12 Months Ended
	Dec. 31, 2022
Fair Value Disclosures [Abstract]
Fair Value Measurement	Fair Value Measurement The following table sets forth the recurring fair value of the Company’s financial assets and liabilities, allocated into the Level 1, Level 2 and Level 3 hierarchy that were measured at fair value on a recurring basis (amounts in thousands): Fair Value Measurements as of December 31, 2022 Level 1 Level 2 Level 3 Total Assets: Money market funds (1) $ 32,035 $ — $ — $ 32,035 U.S. government treasury bills 70,708 — — 70,708 Commercial paper — 53,296 — 53,296 Corporate bonds — 4,250 — 4,250 Government agency — 5,287 — 5,287 Total financial assets $ 102,743 $ 62,833 $ — $ 165,576 Fair Value Measurements as of December 31, 2021 Level 1 Level 2 Level 3 Total Assets: Money market funds (1) $ 140,032 $ — $ — $ 140,032 (1) Included in cash and cash equivalents in the accompanying balance sheets. As of December 31, 2022 gross unrealized losses for cash equivalents and investments was $0.1 million. As of December 31, 2022, all marketable securities had a contractual maturity of less than one year. Intangible Asset Impairment During the year ended December 31, 2021, the Company recognized an impairment of $74.2 million of the contract intangible asset acquired in connection with the Merger and reduced the contract intangible asset to its estimated fair value of $3.9 million at the Effective Time. This represented a Level 3 fair value measurement as factors used to develop the estimated fair value are unobservable inputs that are not supported by market activity. During the year ended December 31, 2022, upon receipt of the Notice of Termination, the Company impaired the contract intangible asset by $3.7 million to its estimated fair value of zero (which represented a Level 3 fair value measurement) based on receipt of the formal notice of termination from Gossamer for the Gossamer License Agreement.

Short-Term Investments and Cash

Short-Term Investments and Cash and Cash Equivalents	12 Months Ended
	Dec. 31, 2022
Investments, Debt and Equity Securities [Abstract]
Short-Term Investments and Cash and Cash Equivalents	Short-Term Investments and Cash and Cash Equivalents The Company's short-term investments, which consist of highly liquid securities, are classified as available-for-sale and are stated at fair value. The following table summarizes the Company's short-term investments (in thousands): Maturity (In Years) Amortized Cost Unrealized Gains Unrealized Losses Fair Value Money market funds $ 32,035 $ — $ — $ 32,035 U.S. government treasury bills Less than 1 70,812 4 (108) 70,708 Commercial paper Less than 1 53,296 — — 53,296 Corporate bonds Less than 1 4,276 — (26) 4,250 Government agency Less than 1 5,272 15 — 5,287 Total $ 165,691 $ 19 $ (134) $ 165,576

Merger

Merger	12 Months Ended
	Dec. 31, 2022
Business Combinations [Abstract]
Merger	Merger The Merger was accounted for as a reverse asset acquisition because substantially all of the fair value was concentrated in cash, working capital, and a long-lived contract intangible asset (See Note 1). The estimated fair value of total consideration given was $110.4 million as detailed below and is based on 3,208,718 shares of common stock, after taking into account the Reverse Stock Split, outstanding immediately prior to the Effective Time. Number of common shares of the combined company to be owned by Aerpio shareholders 3,208,718 Multiplied by the fair value per share of Aerpio common stock on August 26, 2021 $ 33.00 Fair value of Aerpio common stock 105,887,694 Aadi transaction costs 4,500,864 Purchase price $ 110,388,558 The allocation of the purchase price is as follows (amounts in thousands): August 26, 2021 Cash and cash equivalents $ 29,700 Other current assets 2,709 Intangible asset (1) 78,062 Deposits 20 Accounts payable and accrued liabilities (103) Purchase price $ 110,388 (1) The long-lived intangible asset represented Aerpio’s out-licensing agreement with Gossamer Bio., Inc. In accordance with GAAP for asset acquisitions, the excess purchase price over the fair value of the acquired assets and liabilities was ascribed to the acquired contract intangible asset. Subsequently, the Company recorded an impairment and the licensing agreement was terminated. See Note 6 for additional information.

Intangible Asset

Intangible Asset	12 Months Ended
	Dec. 31, 2022
Goodwill and Intangible Assets Disclosure [Abstract]
Intangible Asset	Intangible Asset The Company recorded a long-lived contract intangible asset as a result of the Merger, related to the Gossamer License Agreement, which was assumed in the Merger. In accordance with GAAP, for asset acquisitions, the excess purchase price over the fair value of the acquired assets and liabilities was ascribed to the acquired contract intangible asset. Due to the significant excess purchase price being allocated over the fair value of the acquired contract intangible asset, the Company determined that an indicator of impairment was present. The contract intangible asset was assessed for recoverability using an undiscounted cash flow model, which resulted in undiscounted cash flows below the carrying amount. At the Effective Time, the Company recognized an impairment of $74.2 million to bring the carrying amount of the contract intangible asset down to its estimated fair value of $3.9 million. The fair value estimate of the intangible asset relates to contingent cash flows expected from the out-licensing arrangement, of which 90% of any future net cash proceeds will be remitted to CVR Holders and paid through the CVRs. The useful life of the intangible asset was estimated to be approximately 14.3 years. On April 25, 2022, the Company received a formal notice of termination from Gossamer for the Gossamer License Agreement, relating to Gossamer’s GB004 product candidate, a legacy product candidate of the Company's predecessor, Aerpio, after Gossamer announced that its Phase 2 SHIFT-UC clinical trial studying GB004 in patients with mild-to-moderate active ulcerative colitis did not meet the primary or secondary endpoints at week 12 and the study was being terminated for lack of treatment benefit. The Gossamer License Agreement terminated effective July 24, 2022. Based on the termination of the Gossamer License Agreement, the Company fully impaired the intangible asset, $3.7 million, of which the Gossamer License Agreement is the underlying asset, during the year ended December 31, 2022. Amortization expense was $87,000 and $95,000 for the years ended December 31, 2022 and 2021, respectively. The following table presents a roll forward of the finite-lived intangible asset for the years ended December 31, (amounts in thousands): Year Ended December 31, 2022 2021 Intangible asset, net, beginning of year $ 3,811 $ — Additions — 78,062 Amortization (87) (95) Impairment of contract intangible (3,724) (74,156) Intangible asset, net, end of year $ — $ 3,811

Accrued Liabilities

Accrued Liabilities	12 Months Ended
	Dec. 31, 2022
Accrued Liabilities, Current [Abstract]
Accrued Liabilities	Accrued Liabilities Details of accrued liabilities are presented as follows (amounts in thousands): As of December 31, 2022 2021 Accrued bonus $ 5,463 $ 1,465 Accrued clinical 2,399 2,507 Accrued professional fees 1,814 1,948 Advanced customer payments 1,571 — Accrued salaries and payroll 1,299 152 Accrued contract manufacturing 405 2,287 Accrued other - sales related 1,435 — Accrued other 536 344 Total accrued liabilities $ 14,922 $ 8,703

Operating Lease

Operating Lease	12 Months Ended
	Dec. 31, 2022
Leases [Abstract]
Operating Lease	Operating Lease In April 2019, the Company entered into a twenty-eight month facility lease agreement for office space in Pacific Palisades, California (the “Pacific Palisades Lease”). The Pacific Palisades Lease commenced on May 1, 2019, included four months of rent abatement and a rent escalation clause and was set to expire on August 31, 2021. In August 2021, the Company exercised its option to extend the term of the Pacific Palisades Lease for an additional three-year period and entered into an amendment to the lease agreement (the “Pacific Palisades Lease Amendment”). Pursuant to the Pacific Palisades Lease Amendment, the Company and the landlord agreed to extend the term for an additional period of three (3) years and six (6) months, until February 28, 2025, with an option to renew for an additional three (3) years in accordance with the terms of the Pacific Palisades Lease. Included in the Pacific Palisades Lease Amendment were nine months of rent abatement and a rent escalation clause. In April 2022, the Company entered into a lease agreement for office space in Morristown, New Jersey (the “Morristown Lease”). The Morristown Lease has a term of seventy-three months, unless terminated sooner, and includes rent abatement for the first three months and the forty-seventh and forty-eighth calendar months after lease commencement. Included in the Morristown Lease are fixed rent escalations of approximately 2% on each anniversary year of the lease term. The following table summarizes information related to the Company’s lease (amounts in thousands): As of December 31, 2022 2021 Assets: Operating lease right-of-use assets $ 1,522 $ 557 Liabilities: Operating lease liabilities, current $ 394 $ 131 Operating lease liabilities, non-current 1,267 474 Total operating lease liabilities $ 1,661 $ 605 Rent expense for the years ended December 31, is presented on the following table (amounts in thousands): Year Ended December 31, 2022 2021 Operating lease rent expense $ 382 $ 188 Cash paid for leases and included in operating cash flows for the years ended December 31, is presented on the following table (amounts in thousands): Year Ended December 31, 2022 2021 Cash paid included in operating cash flows $ 291 $ 129 The future minimum lease payments required under the operating lease as of December 31, 2022, are summarized below (amounts in thousands): Future Minimum Lease Payments: 2023 $ 500 2024 512 2025 320 2026 231 2027 280 Thereafter 110 Total minimum lease payments $ 1,953 Less: amount representing interest (292) Present value of operating lease liabilities $ 1,661 Less: operating lease liabilities, current (394) Operating lease liabilities, non-current $ 1,267 Weighted average remaining lease term (in years) 4.53 Weighted average incremental borrowing rate 7.5 %

License Agreements

License Agreements	12 Months Ended
	Dec. 31, 2022
Revenue from Contract with Customer [Abstract]
License Agreements	License Agreements Bristol-Meyers Squibb Company License Agreement On April 9, 2014, the Company entered into a license agreement (as amended the “BMS License Agreement”) with Bristol-Myers Squibb Company (“BMS”) for exclusive rights for certain patents and a non-exclusive license for certain technology and know-how pertaining to FYARRO. The BMS License Agreement will remain in effect from the effective date of April 9, 2014 until expiration of all milestone and royalty payment obligations under the agreement, unless terminated by either of the parties upon giving an advance notice as specified in the BMS License Agreement. Under the terms of the BMS License Agreement, BMS agreed to supply the Company with licensed products of FYARRO necessary for clinical or non-clinical development. Under the terms of the BMS License Agreement, BMS is entitled to receive certain development milestone payments, royalties on net sales from licensed products under the agreement and any sublicense fees. During the year ended December 31, 2022, royalties on net product sales were $1.1 million, of which $0.4 million in royalties were accrued as of December 31, 2022. No payments related to milestones were paid during the years ended December 31, 2022 and 2021. On August 30, 2021, the Company and BMS entered into Amendment No. 1 (the “Amendment”) to the BMS License Agreement related to certain intellectual property rights of BMS pertaining to the compound known as FYARRO. Under the terms of the Amendment, the Company paid BMS $5.8 million representing 50% of the previously outstanding payment obligation under the terms of the BMS License Agreement, following the Effective Time of the 2021 PIPE Financing. Pursuant to the terms of the Amendment, the remaining previously outstanding payment obligation of $5.8 million, is due on the third anniversary of the Effective Time, or August 26, 2024 plus any accrued and unpaid interest due thereon (“Balloon Payment”). The Balloon Payment shall accrue interest, beginning August 26, 2021 until paid in full, at a rate equal to 4.00% per annum based on the weighted average amount outstanding during the applicable calendar quarter, and interest is payable quarterly in arrears. In addition, the parties agreed to amend the royalty rates payable to BMS based on net sales of products subject to the BMS License Agreement. On December 8, 2020, the Company entered into a license agreement (“EOC License Agreement”) with EOC Pharma (Hong Kong) Limited (“EOC”) under which the Company received $14.0 million in January 2021 in non-refundable upfront consideration as partial payment for the rights and licenses granted to EOC by the Company for the further development and commercialization of FYARRO in the People’s Republic of China, Hong Kong Special Administration Region, Macao Special Administrative Region and Taiwan (the “Licensed Territory”). In accordance with the BMS License Agreement, the Company is required to pay 20% of all sublicense fees to BMS. As such, the Company recognized $2.8 million of license expense in the year ended December 31, 2021 and had a corresponding $2.8 million sublicense payable to BMS on the balance sheet as of December 31, 2021, which was paid in 2022. During the year ended December 31, 2021, the Company recognized license revenue and received $1.0 million from EOC for achieving the FDA approval milestone on November 22, 2021. In accordance with the BMS License Agreement, the Company recognized $0.2 million of license expense in the year ended December 31, 2021 and had a corresponding $0.2 million sublicense payable to BMS on the balance sheet as of December 31, 2021, which was paid in 2022. EOC License Agreement In December 2021, the Company entered into the EOC License Agreement with EOC for the further development of ABI-009, now called FYARRO, and commercialization of FYARRO in the Licensed Territory. Under the terms of the agreement, the Company granted to EOC an exclusive, royalty-bearing license to develop and commercialize the product in the Licensed Territory. The term of the EOC License Agreement was set to continue until the expiration of the royalty obligations under the agreement. On June 27, 2022, the Company received written notice from EOC that EOC elected to terminate the EOC License Agreement, effective immediately, due to alleged material breaches by the Company under such agreement. The Company disagrees with EOC’s allegations of material breach and does not believe that EOC had a right to terminate the EOC License Agreement for material breach, and accordingly believes that the termination of the EOC License Agreement is a termination for convenience. EOC had the right to terminate the agreement for convenience upon 120 days advance written notice. The Company waived such notice period in connection with EOC's termination notice and, as a result, the EOC License Agreement was terminated effective June 27, 2022. Either party had the right to terminate the EOC License Agreement in the event that the other party breaches the agreement and fails to cure the breach, becomes insolvent or challenges certain of the intellectual property rights licensed under the agreement. On June 27, 2022, EOC filed a Request for Arbitration with the International Chamber of Commerce’s International Court of Arbitration against the Company. The arbitration process is ongoing. The Company assessed the EOC License Agreement and concluded that EOC is a customer and identified the license of ABI-009 provided to EOC as the sole performance obligation. The $14.0 million upfront payment received from EOC is non-refundable and non-creditable and is considered fixed consideration. The Company recognized revenue of $14.0 million in the year ended December 31, 2020 when the EOC License Agreement was signed, and the $14.0 million upfront payment was received in January 2021. The potential milestone payments and royalty payments under the EOC License Agreement were considered variable consideration and were constrained with respect to revenue recognition notification from EOC that the milestone and royalty payments had been achieved. The Company was eligible to receive an additional $257.0 million in the aggregate upon achievement of certain development, regulatory, and sales milestones, as well as tiered royalties on net sales in the Licensed Territory. Under the terms of the EOC License Agreement, EOC was obligated to fund all research, development, regulatory, marketing and

Convertible Notes

Convertible Notes	12 Months Ended
	Dec. 31, 2022
Debt Disclosure [Abstract]
Convertible Notes	Convertible Notes Private Aadi received $8.1 million in October 2019 (“October 2019 Convertible Notes”) and $1.0 million in January 2020 for the proceeds in connection with the issuance of convertible promissory notes (“January 2020 Convertible Notes,” and together with October 2019 Convertible Notes “Convertible Notes”). The October 2019 Convertible Notes were issued to existing equity holders of Private Aadi. The Convertible Notes originally had a maturity date of one year from the date of issuance and an escalating interest rate of 6% per annum for the first four months following the effective date of the loan agreement, 8% per annum for the fifth and sixth months, and 10% per annum for the remaining six months of the note term until maturity at twelve months. In November 2020, Private Aadi entered into an amendment to the Convertible Notes, whereby the term was extended from one year to two years. The amendment was accounted for as a debt modification. In May 2021, Private Aadi entered into an amendment to the Convertible Notes, whereby upon the closing of the Merger (see Note 1), the outstanding principal amount of the Convertible Notes and all accrued and unpaid interest as of immediately prior to the closing of the Merger would automatically convert into fully paid and nonassessable shares of Private Aadi common stock at a price per share equal to $4.80 and would be concurrently exchanged for shares of the Company’s common stock based on the Exchange Ratio. In conjunction with the closing of the Merger on August 26, 2021, the outstanding Convertible Notes were converted into shares of Private Aadi common stock which were concurrently exchanged for 698,018 shares of the Company’s common stock based on the Exchange Ratio . At the date of conversion, the Convertible Notes were marked to market and valued at $9.5 million, resulting in a gain on conversion of $0.4 million in the year ended December 31, 2021 .

Payroll Protection Program Loan

Payroll Protection Program Loan	12 Months Ended
	Dec. 31, 2022
Payroll Protection Program Loan [Abstract]
Payroll Protection Program Loan	Payroll Protection Program LoanIn May 2020, Private Aadi was approved for a $0.2 million Small Business Administration Paycheck Protection Program loan, as provided for in the Coronavirus Aid, Relief and Economic Security Act (“PPP Loan”). Under certain conditions, the PPP Loan and accrued interest were forgivable after a twenty-four-week covered period as long as the loan proceeds were used for eligible expenses, including payroll, benefits, rent and utilities, and the company maintains certain payroll levels. The amount of loan forgiveness was subject to reduction if the Company terminates employees or reduces salaries during the twenty-four-week covered period. The unforgiven portion of the loan was payable over two years at an interest rate of 1%, with a deferral of payments for the ten months following the end of the twenty-four-week covered period. On April 29, 2021, the Company received notification from the SBA that the Company’s Forgiveness Application of the PPP Loan and accrued interest was approved in full, and the Company had no further obligations related to the PPP Loan. Accordingly, the Company recorded a gain on the forgiveness of the PPP Loan totaling $0.2 million.

Stockholders' Equity (Deficit)

Stockholders' Equity (Deficit)	12 Months Ended
	Dec. 31, 2022
Equity [Abstract]
Stockholders' Equity (Deficit)	Stockholders' Equity (Deficit) Preferred Stock As of December 31, 2022 and 2021, under the Company’s certificate of incorporation, as amended and restated, the Company has 10,000,000 shares of preferred stock, par value $0.0001 per share, in authorized capital with no shares outstanding. Series Seed Preferred Stock On February 23, 2017, Private Aadi converted from a limited liability company to a corporation and at that time converted 734,218 membership units into shares of Series Seed Preferred Stock. All outstanding shares of Series Seed Preferred Stock were converted into Private Aadi’s common stock and concurrently exchanged for the Company’s common stock based on the Exchange Ratio in connection with the closing of the Merger. Series A Preferred Stock In February and March 2017, Private Aadi sold and issued in a private placement 5,847,940 shares of Series A Preferred Stock at $3.42 per share (the “Series A Financing”). Upon the closing of the Series A Financing, convertible notes issued in 2015 converted into 482,426 shares of Series A Preferred Stock at 85% of the $3.42 price per share (the “Series A Original Issue Price”) paid by the Series A Financing investors. Convertible notes issued in 2017 converted into 881,286 shares of Series A Preferred Stock at the Series A Original Issue Price. All outstanding shares of Series A Preferred Stock were converted into shares of Private Aadi common stock and concurrently exchanged for the Company’s common stock based on the Exchange Ratio in connection with the closing of the Merger. Common Stock and Pre-Funded Warrants As of December 31, 2022 and 2021, the Company had 300,000,000 shares of authorized common stock with par value of $0.0001 per share under the Company’s certificate of incorporation, as amended and restated. As of December 31, 2022 and 2021, the shares of common stock outstanding were 24,435,007 and 20,894,695, respectively. In conjunction with the closing of the Merger, the Company issued an aggregate of 2,558,218 shares of common stock to holders of Private Aadi common stock in exchange for all of the Private Aadi capital stock outstanding immediately prior to the closing of the Merger. Concurrently with the closing of the Merger, the 2021 PIPE Investors purchased an aggregate of 11,852,862 shares of the Company’s common stock for an aggregate purchase price of $155.0 million pursuant to the Subscription Agreement entered into with the Company on May 16, 2021. The aggregate net proceeds, after deducting certain expenses incurred that were direct and incremental to the issuance of the 2021 PIPE shares, was $145.4 million. In March 2022, the Company entered into the Sales Agreement with Cowen , with respect to an “at the market offering” program pursuant to which the Company may offer and sell, from time to time at its sole discretion, shares of common stock having aggregate gross proceeds of up to $75.0 million through Cowen as its sales agent . As of December 31, 2022 , no shares of common stock had been sold pursuant to the Sales Agreement. On September 22, 2022, the Company entered into the Purchase Agreement for the 2022 PIPE Financing with the 2022 PIPE Investors for the sale by the Company of 3,373,526 shares of the Company’s common stock for a price of $12.50 per share and Pre-Funded Warrants to purchase an aggregate of 2,426,493 shares of the Company's common stock at a purchase price of $12.4999 per Pre-Funded Warrant. The Pre-Funded Warrants are exercisable at an exercise price of $0.0001 and will be exercisable until exercised in full. The 2022 PIPE Financing closed on September 26, 2022. Aggregated net proceeds, after deducting certain expenses incurred of $0.3 million related to the issuance of the shares were $72.2 million. On September 22, 2022, the Company and the Purchasers entered into the 2022 PIPE Registration Rights Agreement providing for the registration for resale of the securities sold under the Purchase Agreement, including the shares issuable upon the exercise of the Pre-Funded Warrants, that are not then registered on an effective registration statement, pursuant to a registration statement filed with the SEC. The Pre-Funded Warrants meet the criteria to be classified within stockholders’ equity. As of December 31, 2022, all Pre-Funded Warrants are still outstanding. Dividends The holders of common stock are entitled to receive cash dividends, if and when declared by the board of directors of the Company (the “board of directors”). Since the Company’s inception, no cash dividends have been declared or paid to the holders of common stock. Liquidation In the event of any voluntary or involuntary liquidation, dissolution, or winding-up of the Company, the holders of common stock are entitled to share ratably in the Company’s assets. Voting The holders of common stock are entitled to one vote for each share of common stock held at all meetings of stockholders and written actions in lieu of meetings.

Share-Based Compensation

Share-Based Compensation	12 Months Ended
	Dec. 31, 2022
Share-Based Payment Arrangement [Abstract]
Share-Based Compensation	Share-Based Compensation 2014 Plan (as amended and restated in February 2017, the “Private Aadi Plan”) In connection with the Merger, the Company assumed the Private Aadi Plan, which was amended and restated in February 2017, and the issued and outstanding stock options under the Private Aadi Plan (the Private Aadi common stock underlying the awards was adjusted for shares of the Company’s common stock pursuant to the Merger Agreement). The Private Aadi Plan allowed for the grant of incentive stock options, non-statutory stock options, stock appreciation rights, restricted stock unit awards and other stock awards. In connection with the closing of the Merger and the adoption of the 2021 Plan (as defined below), no further awards will be issued under the Private Aadi Plan. The options that are granted from the Private Aadi Plan are exercisable at various dates as determined upon grant and will expire no more than ten years from their date of grant. The Private Aadi Plan stock options generally vest over a four-year term. 2011 Plan and 2017 Plan In connection with the closing of the Merger, the Company assumed the Aerpio 2011 Equity Incentive Plan (the “2011 Plan”) and the Aerpio 2017 Stock Option and Incentive Plan (the “2017 Plan,” and together with the 2011 Plan, the “Prior Plans”). No new awards will be granted under the Prior Plans effective as of the closing of the Merger and adoption of the 2021 Plan (as defined below). 2021 Plan At the closing of the Merger, the Company adopted the Aadi Bioscience, Inc. 2021 Equity Incentive Plan (the “2021 Plan”), which permits the award of stock options stock appreciation rights, restricted stock, restricted stock units, performance units and performance grants to employees, members of the board of directors, and outside consultants. Subject to the adjustment provisions contained in the 2021 Plan and the evergreen provision described below, a total of 2,070,784 shares of common stock were initially reserved for issuance pursuant to the 2021 Plan. In addition, the shares reserved for issuance under the 2021 Plan include any shares of common stock (i) subject to awards of stock options or other awards granted under the Prior Plans that expire or otherwise terminate without having been exercised in full and shares of common stock granted under the Prior Plans that are forfeited or repurchased by the Company, and (ii) any shares of common stock subject to stock options or similar awards granted under the Private Aadi Plan that were assumed in the Merger (provided that the maximum number of shares that may be added to the 2021 Plan pursuant to this sentence is 764,154 shares). The number of shares available for issuance under the 2021 Plan also will include an annual increase, or the evergreen feature, on the first day of each of the Company’s fiscal years, beginning with the Company’s fiscal year 2022, equal to the least of: • 2,070,784 shares of common stock; • a number of shares equal to 4% of the outstanding shares of common stock on the last day of the immediately preceding fiscal year; or • such number of shares as the board of directors or its designated committee may determine. As a result of the evergreen increase, a total of 977,400 shares were added to the 2021 Plan on January 1, 2023. Shares issuable under the 2021 Plan are authorized, but unissued, or reacquired shares of common stock. If an award expires or becomes unexercisable without having been exercised in full, is surrendered pursuant to an exchange program, or, with respect to restricted stock, restricted stock units, performance units or performance shares, is forfeited to or repurchased by the combined company due to failure to vest, the unpurchased shares (or for awards other than stock options or stock appreciation rights, the forfeited or repurchased shares) will become available for future grant or sale under the 2021 Plan (unless the 2021 Plan has terminated). As of December 31, 2022, zero, 299,039, 101,024 and 2,590,360 shares were outstanding under the 2011 Plan, Private Aadi Plan, 2017 Plan and 2021 Plan, respectively. The following table summarizes the stock option activity during the year ended December 31, 2022: Shares Weighted Average Weighted Average Aggregate Outstanding, January 1, 2022 1,749,876 $ 20.71 8.48 $ 10,007 Granted 1,583,038 15.28 Exercised (132,084) 3.04 Expired/cancelled (210,407) 20.61 Outstanding as of December 31, 2022 2,990,423 $ 19.28 8.59 $ 2,849 Options exercisable as of December 31, 2022 722,198 $ 18.53 6.84 $ 2,251 Vested and expected to vest as of December 31, 2022 2,990,423 $ 19.28 8.59 $ 2,849 As of December 31, 2022, the aggregate intrinsic value of options outstanding was $2.8 million. For the years ended December 31, 2022 and 2021, the weighted-average grant-date fair value of options granted was $12.20 and $18.88 per share, respectively. As of December 31, 2022, there was $28.8 million of unrecognized compensation cost related to stock options, which is expected to be recognized over a weighted average period of 2.7 years. The total intrinsic value of the options exercised during the years ended December 31, 2022 and 2021 was $1.3 million and $1.0 million, respectively. As of December 31, 2022, and 2021, 853,760 and 1,390,606 shares were reserved for issuance under the 2021 Plan, respectively. Compensation Expense Summary The Company recognized the following compensation cost related to employee and non-employee share-based compensation activity for the periods presented (amounts in thousands): Year Ended December 31, 2022 2021 Selling, general and administrative $ 6,333 $ 1,449 Research and development 3,310 657 Total $ 9,643 $ 2,106 Included in the year ended December 31, 2021 is $0.3 million of expense related to the acceleration of vesting associated with individual awards assumed in the Merger. In connection with the retirement of an employee, the Company has modified its previously granted equity awards to continue vesting 64,436 shares, which would have otherwise been forfeited in May 2022 as a result of such retirement and extended the exercise ability of the former employee’s vested and outstanding options. The incremental share-based compensation expense as a result of the modification was $0.3 million for the year ended December 31, 2022. The Company uses the Black-Scholes option pricing model to determine the estimated fair value for share-based awards. Option pricing and models require the input of various assumptions, including the option’s expected life, expected dividend yield, price volatility and risk-free interest rate of the underlying stock. The calculation was based on the following assumptions: Year Ended December 31, 2022 2021 Weighted average grant date fair value (per share) $12.20 $18.88 Risk-free interest rate 1.46% - 4.23% 0.84% - 1.38% Expected volatility 85.91% - 89.35% 85.21% - 87.88% Expected term (in years) 5.5 - 6.1 5.1 - 6.3 Expected dividend yield — — The Company determines the assumptions used in the option pricing model in the following manner: Risk-Free Interest Rate – For the determination of the risk-free interest rates, the Company utilizes the U.S. Treasury yield curve for instruments in effect at the time of measurement with a term commensurate with the expected term assumption. Expected Volatility – Due to the Company’s limited historical stock price volatility data, the Company based its estimate of expected volatility on the estimated and expected volatilities of a guideline group of publicly traded companies. For these analyses, the Company selected companies with comparable characteristics including enterprise value, risk profiles, and with historical share price information sufficient to meet the expected life of the share-based awards. The Company computes the historical volatility data using the daily closing prices for the selected companies’ shares during the equivalent period of the calculated expected term of its share-based awards. The Company will continue to apply this process until a sufficient amount of historical information regarding the volatility of its own stock price becomes available. Expected Dividend – The expected dividend yield is assumed to be zero since the Company has never paid dividends and does not have current plans to pay any dividends on its common stock. Expected Term – The Company estimates the expected term of its stock options granted to employees and non-employee directors using the simplified method, whereby, the expected term equals the average of the vesting term and the original contractual term of the option. The Company utilizes this method since it does not have sufficient historical exercise data to provide a reasonable basis upon which to estimate the expected term. Prior to the Company’s Merger, given the absence of a public trading market for the Company’s common stock, its board of directors exercised their judgment and considered a number of objective and subjective factors to determine the best estimate of the fair value of the Company’s common stock underlying the stock options, such as: contemporaneous valuations performed by independent third-party specialists, its stage of development, including the status of its research and development efforts of its therapeutic candidates and the material risks related to its business and industry, its results of operations and financial condition, including its levels of capital resources, the prices at which its sold shares of its convertible preferred stock, the rights, preferences and privileges of its convertible preferred stock relative to those of its common stock, the conditions in the biotechnology industry and the economy in general, the stock price performance and volatility of comparable life sciences public companies, as well as recently completed mergers and acquisitions of peer companies, the likelihood of achieving a liquidity event for the holders of its common stock or convertible preferred stock, such as an IPO or a sale of the Company given prevailing market conditions, trends and developments in its industry, external market conditions affecting the life sciences and biotechnology sectors, and the lack of liquidity of its common stock, among other factors. Subsequent to the Company’s Merger, the fair value of the Company’s common stock is determined based on its closing market price on the date of the grant. The Company’s board of directors intended all options granted to be exercisable at a price per share not less than the per share fair value of its common stock underlying those options on the grant date. Warrants to Purchase Common Stock The Company had warrants outstanding for the purchase of 29,167 and 36,666 shares of the Company’s common stock at December 31, 2022 and 2021, respectively. These warrants were assumed in the Merger and were issued by Aerpio in October 2019, for the purchase of 40,000 shares (after taking into account the Reverse Stock Split) of the Company’s common stock at an exercise price of $7.29 per share (after taking into account the Reverse Stock Split). These warrants were fully vested as of the date of the Merger and expire on October 24, 2024. During the year ended December 31, 2022, 7,500 warrants were exercised. At the grant date, the fair value of these awards was determined using a Black-Scholes option pricing model. The number of shares and the exercise price shall be adjusted for standard anti-dilution events such as stock splits, combinations, reorganizations, or issue shares as part of a stock dividend. The warrants meet the criteria to be classified within stockholders’ equity.

Employee Stock Purchase Plan

Employee Stock Purchase Plan	12 Months Ended
	Dec. 31, 2022
Share-Based Payment Arrangement [Abstract]
Employee Stock Purchase Plan	Employee Stock Purchase Plan On August 17, 2021, a special meeting of the Company’s stockholders was held to approve the Merger and related matters, at which the Company's stockholders considered and approved the Company’s 2021 ESPP which permits participants to contribute up to 15% of their eligible compensation during defined rolling six-month offering periods to purchase the Company’s common stock. The purchase price of the shares will be 85% of the lower of the fair market value of the Company’s common stock on the first day of trading of the offering period or on the applicable purchase date. Upon approval of the 2021 ESPP by the stockholders, Aerpio’s Amended and Restated 2017 Employee Stock Purchase Plan terminated. An aggregate of 519,563 shares of common stock have been reserved for issuance under the 2021 ESPP. The number of shares of common stock available for issuance under the 2021 ESPP will be increased on the first day of each fiscal year beginning with the 2022 fiscal year in an amount equal to the least of (i) 310,617 shares of common stock, (ii) one percent (1%) of the outstanding shares of all classes of common stock on the last day of the immediately preceding fiscal year, or (iii) an amount to be determined by the board of directors or its designated committee no later than the last day of the immediately preceding fiscal year. On January 1, 2023, 244,350 shares of common stock were added to the 2021 ESPP. Shares of common stock issuable under the 2021 ESPP will be authorized, but unissued, or reacquired shares of common stock. If the Company’s capital structure changes because of a stock dividend, stock split or similar event, the number of shares that can be issued under the 2021 ESPP will be appropriately adjusted. The Company opened enrollment into the ESPP in May 2022. The Company uses the Black-Scholes model to determine the estimated fair value for purchases under the 2021 ESPP. Black-Scholes models require the input of various assumptions, including the expected life, expected dividend yield, price volatility and risk-free interest rate of the underlying stock. The calculation was based on the following assumptions: Year Ended Strike price (per share) $11.40 - $11.66 Risk-free interest rate 1.54% - 4.40% Expected volatility 92.59% - 105.68% Expected term (in years) 0.5 Expected dividend yield — As of December 31, 2022 and 2021, 492,361 and 310,617 shares of common stock were available for issuance under the 2021 ESPP, respectively. The Company had an outstanding liability of $76,000 at December 31, 2022, which will be recognized over six months. No liability was outstanding as of December 31, 2021. During the years ended December 31, 2022 and 2021 , 27,202 and zero shares were issued under the 2021 ESPP, respectively.

Income Taxes

Income Taxes	12 Months Ended
	Dec. 31, 2022
Income Tax Disclosure [Abstract]
Income Taxes	Income Taxes The Company recorded income tax expense of zero and $2,000 for the years ended December 31, 2022 and 2021, respectively. The Company continues to maintain a full valuation allowance. A reconciliation of the statutory federal income tax with the provision for income taxes are as follows: Year Ended December 31, 2022 2021 Federal tax at statutory rate 21.0 % 21.0 % State income tax, net of federal benefit 1.8 0.5 Nondeductible interest — (0.1) Other permanent items (0.1) 0.4 Officers Compensation (1.7) — Nondeductible impairment — (13.8) Research credit 2.4 0.9 Change in valuation allowance (23.4) (8.9) Effective tax rate — % — % Significant components of the Company’s deferred tax assets and liabilities are as follows (amounts in thousands): As of December 31, 2022 2021 Deferred tax assets: Net operating loss carryforwards $ 38,548 $ 34,228 Research and development tax credits 5,168 3,732 Section 174 capitalized research expense 5,417 — Other 4,219 1,214 Total deferred tax assets 53,352 39,174 Valuation allowance (52,766) (38,410) Total gross deferred tax assets, net of valuation allowance 586 764 Deferred tax liabilities: Other (586) (764) Total gross deferred tax liabilities (586) (764) Net deferred tax assets / (liabilities) $ — $ — Deferred income tax assets and liabilities are recorded for differences between the financial statement and tax basis of the assets and liabilities that will result in taxable or deductible amounts in the future based on enacted laws and rates applicable to the periods in which the differences are expected to affect taxable income. Valuation allowances are established when necessary to reduce deferred tax assets to the amount expected to be realized in future periods. The Company has evaluated the available evidence supporting the realization of its gross deferred tax assets, including the amount and timing of future taxable income and has determined it is more likely than not that the assets will not be realized. As a result, the Company has concluded that a full valuation allowance against its deferred tax asset is necessary at this time. As of December 31, 2022, the Company has federal and state net operating loss (“NOL”) carryforwards of $167.5 million and $72.0 million, respectively. Of the amount of federal and state NOL carryforwards, $123.4 million and $16.5 million, respectively, can be carried forward indefinitely. The remaining federal and state NOL carryforwards begin to expire in 2030 and 2037 , unless previously utilized. The Company also has federal and state research credit carryforwards of approximately $5.0 million and $2.3 million, respectively, unless previously utilized. The federal and New Jersey research credit carryforwards will begin to expire in 2037 and 2027, respectively, unless previously utilized. The California research and development (“R&D”) credit will carry forward indefinitely. The increase in the valuation allowance is $14.4 million and $28.2 million for the years ended December 31, 2022 and 2021 , respectively. Pursuant to Section 382 and 383 of the Internal Revenue Code (“IRC”), utilization of the Company’s NOL carryforwards and R&D credits may be subject to annual limitations in the event of any significant future changes in its ownership structure. These annual limitations may result in the expiration of NOL carryforwards and R&D credits prior to utilization. As of December 31, 2022, the Company has completed an IRC Section 382 analysis through the date of the Merger. Ownership changes were identified that will result in annual limitations on future utilization of NOL and R&D credit carryforwards. To the extent such limitations will cause NOL and R&D credit carryforwards to expire unused, these tax attributes have been removed from deferred tax asset table above. Uncertain tax positions are evaluated based upon the facts and circumstances that exist at each reporting period. Subsequent changes in judgement based upon new information may lead to changes in recognition, derecognition, and measurement. Adjustment may result, for example, upon resolution of an issue with the taxing authorities or expiration of a statute of limitations barring an assessment for an issue. The Company recognizes a tax benefit from an uncertain tax position when it is more likely than not that the position will be sustained upon examination by tax authorities. The following table summarizes the changes to the Company’s gross unrecognized tax benefits for the years ended December 31, 2022 and 2021 (amounts in thousands): As of December 31, 2022 2021 Balance at the beginning of year $ 2,674 $ 2,404 Decrease related to prior year positions 2 (24) Increase related to current year positions 704 294 Balance at the end of year $ 3,380 $ 2,674 Due to the existence of the valuation allowance, future recognition of previously unrecognized tax benefits will not impact the Company’s effective tax rate. The Company’s practice is to recognize interest and penalties related to income tax matters in income tax expense. The Company is subject to taxation in the United States federal and certain state jurisdictions. The Company’s tax years from inception are subject to examination by the United States federal and state authorities due to the carryforward of unutilized NOLs and R&D credits. The Company does not anticipate the unrecognized tax benefits to change materially within the next twelve months. The Company had no accrued interest and no penalties related to income tax matters in the Company’s balance sheet as of December 31, 2022 and has not recognized interest or penalties in the Company’s statement of operations and loss for the year ended December 31, 2022. Further, the Company is not currently under examination by any federal, state or local tax authority. The CARES Act provides sweeping tax changes in response to the COVID-19 pandemic. Some of the more significant provisions are removal of certain limitations on utilization of NOL’s, increasing the loss carryback period for certain losses to five years, and increasing the ability to deduct interest expense, as well as amending certain provisions of the previously enacted Tax Cuts and Jobs Act. As of December 31, 2022, the Company has not recorded any material adjustments to its income tax provision related to the provisions with the CARES Act. The Company will continue to analyze the impact that the CARES Act will have, if any, on its financial positions, results of operations or cash flows.

Commitments and Contingencies

Commitments and Contingencies	12 Months Ended
	Dec. 31, 2022
Commitments and Contingencies Disclosure [Abstract]
Commitments and Contingencies	Commitments and Contingencies Litigation From time to time, the Company could be subject to various legal proceedings and claims that arise in the ordinary course of its business activities. Regardless of the outcome, legal proceedings can have an adverse impact on the Company because of defense and settlement costs, diversion of management resources and other factors. On June 27, 2022, EOC filed a Request for Arbitration with the International Chamber of Commerce’s International Court of Arbitration against the Company. In the Request for Arbitration, EOC claims that the Company breached certain provisions of the EOC License Agreement, including failing to provide certain manufacturing and clinical development information to EOC. As a result, EOC is seeking monetary damages. The arbitration process is ongoing. The Company intends to defend itself vigorously in this matter and pursue all relief to which the Company is entitled. The Company is unable to estimate the possible loss or range of loss, therefore no amounts have been accrued as of December 31, 2022. See Note 9 to these audited financial statements for more information about the EOC License Agreement and its termination. Purchase Commitments The Company has ongoing contracts with vendors for clinical trials and contract manufacturing. These contracts are generally cancellable, with notice, at the Company’s option. The Company recorded accrued expenses of $2.8 million and $4.8 million in its consolidated balance sheet for expenditures incurred by clinical and contract manufacturing vendors as of December 31, 2022 and 2021, respectively. At December 31, 2022 the Company had one significant contract with Fresenius Kabi that contains specific activities including non-cancellable commitments, minimum purchase commitments, and binding annual forecasts. As of December 31, 2022, there were non-cancellable purchase commitments related to the purchase of inventory for $1.9 million to be paid in 2023. Mirati Collaboration. In October 2022, the Company entered into a collaboration and supply agreement with Mirati Therapeutics, Inc. (“Mirati”) to evaluate the combination of Mirati’s adagrasib, a KRASG12C selective inhibitor, and FYARRO in KRAS G12C mutant non-small cell lung cancer (NSCLC) and other solid tumors. Under the terms of the agreement, Mirati will be responsible for sponsoring and operating the Phase 1/2 study and the Company will supply study drug and jointly share the cost of the study. The primary objective of this multi-center, single-arm, open-label Phase 1/2 trial is to determine the optimal dose and recommended Phase 2 dose for the combination of adagrasib and FYARRO in patients with KRASG12C-mutant solid tumors. In addition, the study will investigate the safety, tolerability and efficacy of adagrasib and FYARRO in combination in patients both with and without prior exposure to a KRASG12C inhibitor. The trial will build on preclinical data showing enhanced anti-tumor efficacy with the combination of adagrasib and FYARRO relative to either agent alone.

Employee Retirement Plan

Employee Retirement Plan	12 Months Ended
	Dec. 31, 2022
Retirement Benefits [Abstract]
Employee Retirement Plan	Employee Retirement Plan The Company maintains a 401(k) plan (the “401k Plan”) created in 2015 for the benefit of its employees. All employees who have attained the age of 21 are eligible to participate in the 401k Plan as of the first entry date, as defined by the 401k Plan document, following the employment date. Each employee can contribute a percentage of compensation up to a maximum of the statutory limits per year. Company contributions are discretionary. Contributions of $0.5 million and zero were made during the years ended December 31, 2022 and 2021.

Summary of Significant Accoun_2

Summary of Significant Accounting Policies (Policies)	12 Months Ended
	Dec. 31, 2022
Accounting Policies [Abstract]
Basis of Presentation	Basis of Presentation The consolidated financial statements, and the related disclosures, have been prepared in accordance with GAAP and SEC regulations and, in the opinion of management include all adjustments necessary for a fair presentation of the results of operations, financial position, changes in stockholders’ equity and cash flows for each period presented. Any reference in these notes to applicable guidance is meant to refer to the authoritative GAAP as found in the Accounting Standards Codification (“ASC”) and Accounting Standards Updates (“ASU”) of the Financial Accounting Standards Board (“FASB”). All adjustments are of a normal recurring nature. The Company’s consolidated financial statements are stated in U.S. dollars. Certain prior year amounts have been reclassified to conform to the current year presentation. On August 26, 2021, when the Company closed the Merger, all outstanding shares of common stock along with preferred stock of Private Aadi were exchanged for new shares of common stock of the Company and the approximately 8.1 million shares of Private Aadi capital stock held by stockholders of Private Aadi immediately prior to the Merger were exchanged for approximately 2.5 million shares of common stock of the Company based on the Exchange Ratio. The authorized number of shares of common stock was not reduced and remains at 300.0 million. The par value of the Company’s common stock remains unchanged at $0.0001 per share. Also on August 26, 2021, and immediately prior to the closing of the Merger, the Company effected the Reverse Stock Split. Accordingly, all share and per share amounts for the period presented in the accompanying consolidated financial
Comprehensive Loss	Comprehensive Loss Comprehensive loss is defined as the change in equity during a period from transactions and other events and circumstances from non-owner sources, including unrealized gains and losses on short-term investments. Comprehensive loss has been reflected in the statements of operations and comprehensive loss for all periods presented.
Segment Information	Segment InformationOperating segments are defined as components of an enterprise about which separate discrete information is available for evaluation by the chief operating decision maker, or decision-making group, in deciding how to allocate resources and in assessing performance. The Company has identified its Chief Executive Officer as the chief operating decision maker and the Company views its operations and manages its business in one operating segment, which is the business of developing and commercializing proprietary therapeutics. All the assets and operations of the Company’s sole operating and reportable segment are located in the United States.
Use of Estimates	Use of EstimatesThe preparation of financial statements in conformity with GAAP requires management to make estimates and assumptions that impact the reported amounts of assets, liabilities, revenues and expenses, and the disclosure of contingent assets and liabilities in the Company’s consolidated financial statements and accompanying notes. In the opinion of management, all adjustments that are considered necessary for fair presentation have been included. The most significant estimates in the Company’s consolidated financial statements relate to fair value of the intangible asset, fair value of the convertible promissory notes, gross-to-net accruals, share-based compensation expense and accrued research and development costs. Although these estimates are based on the Company’s knowledge of current events and actions it may undertake in the future, actual results may materially differ from these estimates and assumptions.
Concentration of Credit Risk	Concentrat ion of Credit Risk Financial instruments, which potentially subject the Company to concentration of credit risk, consist primarily of cash and cash equivalents, and investments in money market funds, United States government treasury bills, commercial paper, corporate bonds, and government agency debt securities. The Company maintains deposits in federally insured financial institutions in excess of federally insured limits. Management believes that the Company is not exposed to significant credit risk due to the financial position of the depository institutions in which those deposits are held. While the Company has not experienced any losses in such deposits, the recent failure of Silicon Valley Bank, at which the Company holds cash and cash equivalents in multiple accounts, exposed the Company to credit risk prior to the resolution by the Federal Deposit Insurance Corporation in a manner that fully protected all depositors. The Company has not experienced any losses on deposits since inception. The Company’s accounts receivable is derived from customers located principally in the United States. The Company performs ongoing credit evaluations of its customers and maintains allowances for potential credit losses on customers’ accounts when deemed necessary. The Company does not typically require collateral from its customers. Credit losses historically have not been material. The Company continuously monitors customer payments and maintains an allowance for doubtful accounts based on its assessment of various factors including historical experience, age of the receivable balances, and other current economic conditions or other factors that may affect customers’ ability to pay.
Cash, Cash Equivalents and Restricted Cash	Cash, Cash Equivalents and Restricted Cash The Company considers all highly liquid marketable securities purchased with original maturities of three months or less at the time of purchase date to be cash equivalents. As of December 31, 2022
Fair Value Option	Fair Value Option The Company elected the fair value option to account for its convertible promissory notes which were issued in 2019 and 2020. The Company recorded the convertible promissory notes at fair value with changes in fair value recorded in the statements of operations. As of December 31, 2022 and 2021, there were no convertible notes outstanding as they were converted to shares of Private Aadi common stock immediately prior to the closing of the Merger.
Fair Value of Financial Instruments	Fair Value of Financial Instruments The accounting guidance defines fair value, establishes a consistent framework for measuring fair value, and expands disclosure for each major asset and liability category measured at fair value on either a recurring or nonrecurring basis. Fair value is defined as an exit price representing the amount that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants. As such, fair value is a market-based measurement that should be determined based on assumptions that market participants would use in pricing an asset or liability. As a basis for considering such assumptions, the accounting guidance establishes a three-tier fair value hierarchy, which prioritizes the inputs used in measuring fair value as follows: Level 1: Observable inputs, such as quoted prices in active markets Level 2: Inputs, other than the quoted prices in active markets that are observable either directly or indirectly Level 3: Unobservable inputs in which there is little or no market data, which require the reporting entity to develop its own assumptions which reflect those that a market participant would use Financial assets and liabilities are classified in their entirety based on the lowest level of input that is significant to the fair value measurement. The Company’s assessment of the significance of a particular input to the fair value measurement requires judgment and may affect the valuation of fair value assets and liabilities and their placement within the fair value hierarchy levels. In determining the fair value of its financial instruments, the Company considers the source of observable market data inputs, liquidity of the instrument, the credit risk of the counterparty to the contract, and its risk of nonperformance. In the case fair value is not observable, for the items subject to fair value measurements, the Company applies valuation techniques deemed the most appropriate under the GAAP guidance based on the nature of the assets and liabilities being measured. The carrying amounts of cash and cash equivalents, accounts receivable, prepaid expenses and other current assets and accounts payable are reasonable estimates of their fair value because of the short maturity of these items.
Short-Term Investments	Short-term investments The Company invests in various types of securities, including United States government and commercial paper and corporate debt securities. The Company classifies its investments as available-for-sale and records them at fair value based upon market prices at period end. Unrealized gains and losses that are deemed temporary in nature are recorded in accumulated other comprehensive loss as a separate component of stockholders’ equity. Dividend and interest income are recognized when earned. Realized gains and losses are included in earnings and are derived using the specific identification method for determining the cost of investments sold. The Company classifies short-term investments wi th remaining maturities greater than one year as current assets because such short-term investments are available to fund the Company’s current operations. At each balance sheet date, the Company assesses available-for-sale securities in an unrealized loss position to determine whether the unrealized loss is other-than-temporary. When the Company determines that a decline in the fair value below its cost basis is other-than-temporary, the Company recognizes an impairment loss in the period in which the other-than-temporary decline occurred. There have been no other-than-temporary impairments recognized during any of the periods presented. See Note 4 for further informatio n.
Accounts Receivable, Net	Accounts Receivable, Net Accounts receivable are recorded net of customer allowances for chargebacks and allowance for doubtful accounts. Allowance for chargebacks is based on contractual terms. The Company estimates the allowance for doubtful accounts based on existing contractual payment terms, actual payment patterns of its customers and individual customer circumstances. As of December 31, 2022, $0.1 million of customer allowances for chargebacks was recorded. No allowances were recorded as of December 31, 2021. No receivables were written off for the years ended December 31, 2022 and 2021.
Inventory	InventoryInventory is stated at the lower of cost or estimated net realizable value. The Company uses actual costing methodology determined on a first-in, first-out method. The Company capitalizes inventory costs associated with its products based upon regulatory approval when, based on management’s judgment, future commercialization is considered probable and the future economic benefit is expected to be realized; otherwise, such costs are expensed. Prior to FDA approval of FYARRO, all costs related to the manufacturing of FYARRO were charged to research and development expense in the period incurred, therefore the inventory balance was zero at December 31, 2021.
Property and Equipment, Net	Property and Equipment, Net Property and equipment, consisting of computers, furniture and fixtures, office equipment, construction in process and leasehold improvements are stated at cost, less accumulated depreciation. Property and equipment is depreciated using the straight-line method over the estimated useful lives of the assets, generally three
Intangible Asset, Net	Intangible Asset, Net The Company’s intangible asset consisted of a single asset, the Gossamer License Agreement, assumed in the Merger. The intangible asset was stated at fair value and amortized using the straight-line method over its estimated useful life of 14.3 years. During the year ended December 31, 2021, the acquired intangible asset was reduced to its estimated fair value of $3.9 million at the Effective Time. During the year ended December 31, 2022, the intangible asset's fair value was reduced to zero based on the termination of the Gossamer License Agreement effective July 24, 2022 (see Note 6).
Impairment of Long-Lived Assets	Impairment of Long-Lived Assets The Company reviews long-lived assets, including property, equipment, and the intangible asset for impairment whenever events or changes in circumstances indicate that the carrying amount of the assets may not be recoverable. An impairment loss would be recognized when estimated undiscounted future cash flows expected to result from the use of the asset and its eventual disposition are less than the carrying amount. The impairment loss, if recognized, would be based on the excess of the carrying value of the impaired asset over its respective fair value. An impairment was recorded for the long-lived
Leases	Leases At the inception of a contractual arrangement, the Company determines whether the contract contains a lease by assessing whether there is an identified asset and whether the contract conveys the right to control the use of the identified asset in exchange for consideration over a period of time. If both criteria are met, the Company records the associated lease liability and corresponding right-of-use asset upon commencement of the lease using the implicit rate or a discount rate based on a credit-adjusted secured borrowing rate commensurate with the term of the lease. The Company does not recognize assets or liabilities for leases with lease terms of less than 12 months. The Company additionally evaluates leases at their inception to determine if they are to be accounted for as an operating lease or a finance lease. A lease is accounted for as a finance lease if it meets one of the following five criteria: (i) the lease has a purchase option that is reasonably certain of being exercised, (ii) the present value of the future cash flows is substantially all of the fair market value of the underlying asset, (iii) the lease term is for a significant portion of the remaining economic life of the underlying asset, (iv) the title to the underlying asset transfers at the end of the lease term, or (v) if the underlying asset is of such a specialized nature that it is expected to have no alternative uses to the lessor at the end of the term. Leases that do not meet the finance lease criteria are accounted for as an operating lease. Operating lease assets represent a right to use an underlying asset for the lease term and operating lease liabilities represent an obligation to make lease payments arising from the lease. Operating lease liabilities with a term greater than one year and their corresponding right-of-use assets are recognized on the balance sheet at the commencement date of the lease based on the present value of lease payments over the expected lease term. Certain adjustments to the right-of-use asset may be required for items such as initial direct costs paid or incentives received. As the Company’s leases do not typically provide an implicit rate, the Company utilizes the appropriate incremental borrowing rate, determined as the rate of interest that the Company would have to pay to borrow on a collateralized basis over a similar term and in a similar economic environment. For finance leases, depreciation expense is recognized for the leased asset acquired and interest expense is recognized related to the portion of the financing in the statements of operations and comprehensive loss. For operating leases, lease cost is recognized on a straight-line basis over the lease term and variable lease payments are recognized as operating expense in the period in which the obligation for those payments is incurred. Variable lease payments primarily include common area maintenance, utilities, real estate taxes, insurance, and other operating costs that are passed on from the lessor in proportion to the space leased by the Company. The Company has elected the practical expedient to not separate between lease and non-lease components.
Commitments and Contingencies	Commitments and Contingencies The Company recognizes a liability with regard to loss contingencies when it believes it is probable a liability has been incurred, and the amount can be reasonably estimated. If some amount within a range of loss appears at the time to be a better estimate than any other amount within the range, the Company accrues that amount. When no amount within the range is a better estimate than any other amount the Company accrues the minimum amount in the range. The Company has not recorded any such liabilities as of December 31, 2022 and 2021 .
Revenue Recognition and Related Allowances	Revenue Recognition and Related Allowances The Company recognizes revenue when its customer obtains control of promised goods or services, in an amount that reflects the consideration which the entity expects to receive in exchange for those goods or services. To determine revenue recognition for arrangements that the Company determines are within the scope of ASC Topic 606, Revenue from Contracts with Customers (“Topic 606”), the Company performs the following five steps: (i) identify the contract(s) with a customer; (ii) identify the performance obligations in the contract; (iii) determine the transaction price; (iv) allocate the transaction price to the performance obligations in the contract; and (v) recognize revenue when (or as) the Company satisfies a performance obligation. The Company only applies the five-step model to contracts when it is probable that it will collect the consideration it is entitled to in exchange for the goods or services it transfers to the customer. At contract inception, once the contract is determined to be within the scope of Topic 606, the Company assesses the goods or services promised within each contract and determines those that are performance obligations and assesses whether each promised good or service is distinct. The Company then recognizes as revenue the amount of the transaction price that is allocated to the respective performance obligation when (or as) the performance obligation is satisfied. Product Net Sales FYARRO was approved by the FDA in November 2021. On February 22, 2022, the Company launched sales of FYARRO to specialty distributors (“SDs”) and a specialty pharmacy (“SP”). The Company recognizes product sales when the SDs and SP obtain control of the product. Product sales are recorded at the net sales price, which includes provisions for the following allowances which are reflected either as a reduction to the related account receivable or as an accrued liability, depending on how the allowance is settled: Distribution Fees : Distribution fees include distribution service fees paid to the SDs and SP based on a contractually fixed percentage of the wholesale acquisition cost (“WAC”). Distribution fees are recorded as an offset to product sales based on contractual terms at the time revenue from the sale is recognized. Rebates : Allowance for rebates includes mandated discounts under the Medicaid Drug Rebate Program and TRICARE program. Rebates are amounts owed after the final dispensing of the product to a benefit plan participant and are based upon contractual agreements or statutory requirements. The allowance for rebates is based on contracted or statutory discount rates and expected utilization by benefit plan participants. The Company’s estimates for expected utilization of rebates are based on utilization data received from the SDs and SP since product launch. Rebates are generally invoiced and paid in arrears so that the accrual balance consists of an estimate of the amount expected to be incurred for the current quarter’s activity. If actual future rebates vary from estimates, the Company may need to adjust prior period accruals, which would affect product sales in the period of adjustment. Chargebacks: Chargebacks are discounts and fees that relate to contracts with government and other entities purchasing from the SDs and SP at a discounted price. The SDs and SP charge back to the Company the difference between the price initially paid by the SDs and SP and the discounted price paid to the SDs and SP by these entities. If actual future chargebacks vary from these estimates, the Company may need to adjust prior period accruals, which would affect product sales in the period of adjustment. Co-Payment Assistance: The Company offers co-payment assistance to commercially insured patients meeting certain eligibility requirement. Co-payment assistance is accrued at the time of product sale to SDs and SP based on estimated patient participation and average co-pay benefit to be paid per a claim. The Company estimated amounts are compared to actual program participation and co-pay amounts paid using data provided by third-party administrators. If actual amounts differ from the original estimates the assumptions being applied are updated and adjustment for prior period accruals will be adjusted in the current period. Product Returns: Consistent with industry practice, the Company offers the SDs and SP limited product return rights for damages, shipment errors, and expiring product, provided that the return is within a specified period around the product expiration date as set forth in the applicable individual distribution agreement. The Company does not allow product returns for product that has been dispensed to a patient. As the Company receives inventory reports from the SDs and SP and has the ability to control the amount of product that is sold to the SDs and SP the Company’s estimate of future potential product returns is based on the on-hand channel inventory data and sell-through data obtained from the SDs and SP. In arriving at its estimate, the Company also considers historical product returns, the underlying product demand, and industry data specific to the specialty pharmaceutical distribution industry. Grant Revenue The Company’s grant revenues are derived from federal grants with the FDA. The Company has determined that the government agencies providing grants to the Company are not customers. Grant revenue is recognized when there is reasonable assurance of compliance with the conditions of the grant and reasonable assurance that the grant revenue will be received. The Company recognizes grant revenues as reimbursable grant costs are incurred. The costs associated with these reimbursements are reflected as a component of research and development expense in the accompanying statements of operations and comprehensive loss. With respect to grant revenue derived from reimbursement of direct out-of-pocket expenses for research costs associated with federal contracts, where the Company acts as principal with discretion to choose suppliers, bears credit risk, and performs part of the services required in the transaction, the Company records revenue for the gross amount of the reimbursement. The costs associated with these reimbursements are reflected as a component of research and development expense in the accompanying statements of operations and comprehensive loss. Revenue Under License Agreement The Company generates revenues from payments received under a license agreement. Under such license agreement, the Company recognizes revenue when it transfers promised goods or services to partners in an amount that reflects the consideration to which the Company expects to be entitled in exchange for those goods or services. To determine revenue recognition for contracts with partners, the Company performs the following five steps: (i) identifies the promised goods or services in the contract; (ii) identifies the performance obligations in the contract, including whether they are distinct in the context of the contract; (iii) determines the transaction price, including the constraint on variable consideration; (iv) allocates the transaction price to the performance obligations in the contract; and (v) recognizes revenue when (or as) the Company satisfies the performance obligations. For revenue from such license agreement, the Company generally collects an upfront license payment from the license partner and is also entitled to receive event-based payments subject to the license partner’s achievement of specified development, regulatory and sales-based milestones. In addition, the Company is generally entitled to royalties if products under the license agreement are commercialized. Transaction price for a contract represents the amount to which the Company is entitled in exchange for providing goods and services to the partner. Transaction price does not include amounts subject to uncertainties unless it is probable that there will be no significant reversal of revenue when the uncertainty is resolved. Apart from the upfront license payment, all other fees the Company may earn under such license agreements are subject to significant uncertainties of product development. Achievement of many of the event-based development and regulatory milestones may not be probable until such milestones are actually achieved. This generally relates to milestones such as obtaining regulatory approvals and successful completion of clinical trials. With respect to other development milestones, e.g., dosing of a first patient in a clinical trial, achievement could be considered probable prior to its actual occurrence, based on the progress towards commencement of the trial. The Company does not include any amounts subject to uncertainties in the transaction price until it is probable that the amount will not result in a significant reversal of revenue in the future. At the end of each reporting period, the Company re-evaluates the probability of achievement of such milestones and any related constraint, and if necessary, adjusts the estimate of the overall transaction price. Because such agreements generally only have one type of performance obligation, a license, which is generally all transferred at the same time as agreement inception, allocation of the transaction price among multiple performance obligations is not required. Upfront amounts allocated to licenses are recognized as revenue when the licenses are transferred to the partners. Development milestones and other fees are recognized in revenue when their occurrence becomes probable.
Research and Development	Research and Development Research and development expenses consist of costs incurred in performing research and development activities, including salaries and benefits, materials and supplies, preclinical expenses, share-based compensation expense, contract services, and other external development expenses. The Company records research and development activities conducted by third-party service providers, which include work related to preclinical studies, clinical trials, and contract manufacturing activities, to research and development expense as incurred. The Company is required to estimate the amount of services provided but not yet invoiced and include these expenses in accrued expenses on the balance sheet and within research and development expenses in the statements of operations and comprehensive loss. These expenses are a significant component of the Company’s
Share-Based Compensation	Share-Based Compensation The Company recognizes all share-based payments to employees, including grants of employee stock options in the consolidated statements of operations and comprehensive loss based on their fair values. All of the Company’s share-based awards, to employees, non-employees, officers, and directors, are subject only to service-based vesting conditions. The Company estimates the fair value of its share-based awards using the Black-Scholes option pricing model, which requires the input of assumptions, including (i) the expected stock price volatility, (ii) the calculation of expected term of the award, (iii) the risk-free interest rate and (iv) expected dividends. Options granted during the year have a maximum contractual term of ten years. Forfeitures are recognized and accounted for as they occur. Due to the historical lack of a public market for the trading of the Company’s securities and a lack of company-specific historical and implied volatility data, the Company has based its estimate of expected volatility on the historical volatility of a group of similar companies that are publicly traded. The computation of expected volatility is based on the historical volatility of a representative group of companies with similar characteristics to the Company, including stage of product development and life science industry focus. The Company believes the group selected has sufficient similar economic and industry characteristics and includes companies that are most representative of the Company. The Company has limited historical stock option activity and therefore estimates the expected term of stock options granted to employees, officers, and directors using the simplified method, which represents the average of the contractual term of the stock option and its weighted-average vesting period, to calculate the expected term, as it does not have sufficient historical exercise data to provide a reasonable basis upon which to estimate the expected term for options granted to employees, and utilizes the contractual term for options granted to non-employees. The expected term is applied to the stock option grant group as a whole, as the Company does not expect substantially different exercise or post-vesting termination behavior among its employee population. The risk-free interest rate is based on the U.S. Treasury yield in effect at the time of the grant for zero-coupon U.S. Treasury notes with maturities approximately equal to the expected term of the stock options. Compensation expense related to awards to employees is calculated on a straight-line basis by recognizing the grant date fair value over the associated service period of the award, which is generally the vesting term. Employee Stock Purchase Plan
Income Taxes	Income Taxes Income taxes have been accounted for using the asset and liability method. Under the asset and liability method, deferred tax assets and liabilities are recognized for the future tax consequences attributable to differences between the financial carrying amounts of existing assets and liabilities and their respective tax bases and operating loss and tax credit carryforwards. Deferred tax assets and liabilities are measured using enacted tax rates applicable to taxable income in the years in which those temporary differences are expected to be recovered or settled. The effect on deferred tax assets and liabilities of a change in tax rates is recognized in income in the period that includes the enactment date. A valuation allowance against deferred tax assets is recorded if, based upon the weight of all available evidence, it is more likely than not that some or all of the deferred tax assets will not be realized. When uncertain tax positions exist, the Company recognizes the tax benefit of tax positions to the extent that the benefit will more likely than not be realized. The determination as to whether the tax benefit will more likely than not be realized is based upon the technical merits of the tax position, as well as consideration of the available facts and circumstances. The Company recognizes interest and penalties related to uncertain tax positions, if any exist, in income tax expense.
Net Loss per Share Attributable to Common Stockholders	Net Loss per Share Attributable to Common Stockholders Basic net loss per share is calculated by dividing the net loss attributable to common stockholders by the weighted-average number of common shares outstanding for the period. Basic and diluted weighted average shares of common stock outstanding for the year ended December 31, 2022, includes the weighted average effect of 2,426,493 Pre-Funded Warrants, which were issued in September 2022, for the purchase of shares of common stock, for which the remaining unfunded exercise price is $0.0001 per share. Diluted net loss per share is computed by dividing the net loss attributable to common stockholders by the weighted average number of common shares and common share equivalents outstanding for the period. Common stock equivalents are only included when their effect is dilutive. The Company’s potentially dilutive securities, which include convertible promissory notes, convertible preferred stock, outstanding stock options and warrants have been excluded from the computation of diluted net loss per share as they would be anti-dilutive. Net loss per share is presented as the more dilutive of the treasury stock and as-converted method or the two-class method required for participating securities. The Series A convertible preferred stock is considered a participating security and does not have a contractual obligation to share in Private Aadi’s losses. As such, the two-class method was not required.
Accounting Pronouncements Not Yet Adopted	Accounting Pronouncements Not Yet Adopted In August 2020, the FASB issued ASU 2020-06, “ Debt – Debt with Conversion and Other Options” (Subtopic 470-20) and “Derivatives and Hedging – Contracts in Entity’s Own Equity” (Subtopic 815-40). This new guidance is intended to reduce the complexity of accounting for convertible instruments. The guidance also addresses how convertible instruments are accounted for in the diluted earnings per share calculation and requires enhanced disclosures about the terms of convertible instruments. Entities may adopt ASU 2020-06 using either a partial retrospective or fully retrospective method of transition. This ASU is effective for fiscal years beginning after December 15, 2023, including interim periods within those fiscal years for smaller reporting companies. The Company is currently evaluating the impact the adoption of ASU 2020-06 will have on the Company’s consolidated financial statements. In 2016, the FASB issued ASU 2016-13 “ Financial Instruments - Credit Losses” which (i) significantly changes the impairment model for most financial assets that are measured at amortized cost and certain other instruments from an incurred loss model to an expected loss model which will be based on an estimate of current expected credit loss; and (ii) provides for recording credit losses on available-for-sale debt securities through an allowance account. The standard also requires certain incremental disclosures. Subsequently, the FASB issued several ASUs to clarify, improve, or defer the adoption of ASU 2016-13. This ASU is effective for fiscal years beginning January 2023. The Company is currently evaluating the impact the adoption of ASU 2016-13 will have on the Company's financial statements.

Summary of Significant Accoun_3

Summary of Significant Accounting Policies (Tables)	12 Months Ended
	Dec. 31, 2022
Accounting Policies [Abstract]
Schedule of Cash and Cash Equivalents	The following table provides a reconciliation of cash, cash equivalents and restricted cash reported within the consolidated statements of cash flows (amounts in thousands): As of December 31, 2022 2021 Cash and cash equivalents $ 39,019 $ 148,989 Restricted cash, non-current 64 — Total cash, cash equivalents and restricted cash $ 39,083 $ 148,989
Schedule of Restricted Cash and Cash Equivalents	The following table provides a reconciliation of cash, cash equivalents and restricted cash reported within the consolidated statements of cash flows (amounts in thousands): As of December 31, 2022 2021 Cash and cash equivalents $ 39,019 $ 148,989 Restricted cash, non-current 64 — Total cash, cash equivalents and restricted cash $ 39,083 $ 148,989
Schedule of Inventory	Details of inventory are presented as follows (amounts in thousands). As of December 31, 2022 Raw materials $ 944 Work in process — Finished goods 917 Total $ 1,861
Schedule of Property and Equipment	Details of property and equipment are presented as follows (amounts in thousands). As of December 31, 2022 2021 Computers and software $ 338 $ 51 Construction in process 77 — Furniture and fixtures 65 36 Leasehold improvements 129 — Total $ 609 $ 87 Accumulated depreciation (101) (30) Property and equipment, net $ 508 $ 57
Schedule of Gross-to-Net Sales Adjustments	The following table summarizes the consolidated activities and ending balance of all of the Company's gross-to-net sales adjustments (amounts in thousands): Balance at Beginning of Year Provision for Current Period Sales Payments Balance at End of Year Year ended December 31, 2022 $ — $ 2,438 $ (1,004) $ 1,434
Schedule of Potentially Dilutive Securities Excluded from Calculation of Diluted Net Loss Per Share	The following table sets forth the outstanding potentially dilutive securities that have been excluded in the calculation of diluted net loss per share because their inclusion would be anti-dilutive Year Ended December 31, 2022 2021 Options to purchase common stock 2,990,423 1,749,876 Warrants to purchase common stock 29,167 36,667

Fair Value Measurement (Tables)

Fair Value Measurement (Tables)	12 Months Ended
	Dec. 31, 2022
Fair Value Disclosures [Abstract]
Schedule of Fair Value of Assets and Liabilities Measured on Recurring Basis	The following table sets forth the recurring fair value of the Company’s financial assets and liabilities, allocated into the Level 1, Level 2 and Level 3 hierarchy that were measured at fair value on a recurring basis (amounts in thousands): Fair Value Measurements as of December 31, 2022 Level 1 Level 2 Level 3 Total Assets: Money market funds (1) $ 32,035 $ — $ — $ 32,035 U.S. government treasury bills 70,708 — — 70,708 Commercial paper — 53,296 — 53,296 Corporate bonds — 4,250 — 4,250 Government agency — 5,287 — 5,287 Total financial assets $ 102,743 $ 62,833 $ — $ 165,576 Fair Value Measurements as of December 31, 2021 Level 1 Level 2 Level 3 Total Assets: Money market funds (1) $ 140,032 $ — $ — $ 140,032 (1) Included in cash and cash equivalents in the accompanying balance sheets.

Short-Term Investments and Ca_2

Short-Term Investments and Cash and Cash Equivalents (Tables)	12 Months Ended
	Dec. 31, 2022
Investments, Debt and Equity Securities [Abstract]
Schedule of Short-Term Investments	The Company's short-term investments, which consist of highly liquid securities, are classified as available-for-sale and are stated at fair value. The following table summarizes the Company's short-term investments (in thousands): Maturity (In Years) Amortized Cost Unrealized Gains Unrealized Losses Fair Value Money market funds $ 32,035 $ — $ — $ 32,035 U.S. government treasury bills Less than 1 70,812 4 (108) 70,708 Commercial paper Less than 1 53,296 — — 53,296 Corporate bonds Less than 1 4,276 — (26) 4,250 Government agency Less than 1 5,272 15 — 5,287 Total $ 165,691 $ 19 $ (134) $ 165,576

Merger (Tables)

Merger (Tables)	12 Months Ended
	Dec. 31, 2022
Business Combinations [Abstract]
Schedule of Estimated Fair Value Consideration	The estimated fair value of total consideration given was $110.4 million as detailed below and is based on 3,208,718 shares of common stock, after taking into account the Reverse Stock Split, outstanding immediately prior to the Effective Time. Number of common shares of the combined company to be owned by Aerpio shareholders 3,208,718 Multiplied by the fair value per share of Aerpio common stock on August 26, 2021 $ 33.00 Fair value of Aerpio common stock 105,887,694 Aadi transaction costs 4,500,864 Purchase price $ 110,388,558
Summary of Allocation of Purchase Price	The allocation of the purchase price is as follows (amounts in thousands): August 26, 2021 Cash and cash equivalents $ 29,700 Other current assets 2,709 Intangible asset (1) 78,062 Deposits 20 Accounts payable and accrued liabilities (103) Purchase price $ 110,388 (1) The long-lived intangible asset represented Aerpio’s out-licensing agreement with Gossamer Bio., Inc. In accordance with GAAP for asset acquisitions, the excess purchase price over the fair value of the acquired assets and liabilities was ascribed to the acquired contract intangible asset. Subsequently, the Company recorded an impairment and the licensing agreement was terminated. See Note 6 for additional information.

Intangible Asset (Tables)

Intangible Asset (Tables)	12 Months Ended
	Dec. 31, 2022
Goodwill and Intangible Assets Disclosure [Abstract]
Schedule of Amortization Expense and Impairment of Finite-Lived Intangible Asset	The following table presents a roll forward of the finite-lived intangible asset for the years ended December 31, (amounts in thousands): Year Ended December 31, 2022 2021 Intangible asset, net, beginning of year $ 3,811 $ — Additions — 78,062 Amortization (87) (95) Impairment of contract intangible (3,724) (74,156) Intangible asset, net, end of year $ — $ 3,811

Accrued Liabilities (Tables)

Accrued Liabilities (Tables)	12 Months Ended
	Dec. 31, 2022
Accrued Liabilities, Current [Abstract]
Schedule of Accrued Liabilities	Details of accrued liabilities are presented as follows (amounts in thousands): As of December 31, 2022 2021 Accrued bonus $ 5,463 $ 1,465 Accrued clinical 2,399 2,507 Accrued professional fees 1,814 1,948 Advanced customer payments 1,571 — Accrued salaries and payroll 1,299 152 Accrued contract manufacturing 405 2,287 Accrued other - sales related 1,435 — Accrued other 536 344 Total accrued liabilities $ 14,922 $ 8,703

Operating Lease (Tables)

Operating Lease (Tables)	12 Months Ended
	Dec. 31, 2022
Leases [Abstract]
Summary of Information Related to Lease	The following table summarizes information related to the Company’s lease (amounts in thousands): As of December 31, 2022 2021 Assets: Operating lease right-of-use assets $ 1,522 $ 557 Liabilities: Operating lease liabilities, current $ 394 $ 131 Operating lease liabilities, non-current 1,267 474 Total operating lease liabilities $ 1,661 $ 605
Schedule of Rent Expense	Rent expense for the years ended December 31, is presented on the following table (amounts in thousands): Year Ended December 31, 2022 2021 Operating lease rent expense $ 382 $ 188 Cash paid for leases and included in operating cash flows for the years ended December 31, is presented on the following table (amounts in thousands): Year Ended December 31, 2022 2021 Cash paid included in operating cash flows $ 291 $ 129
Summary of Future Minimum Lease Payments Required under Operating Lease	The future minimum lease payments required under the operating lease as of December 31, 2022, are summarized below (amounts in thousands): Future Minimum Lease Payments: 2023 $ 500 2024 512 2025 320 2026 231 2027 280 Thereafter 110 Total minimum lease payments $ 1,953 Less: amount representing interest (292) Present value of operating lease liabilities $ 1,661 Less: operating lease liabilities, current (394) Operating lease liabilities, non-current $ 1,267 Weighted average remaining lease term (in years) 4.53 Weighted average incremental borrowing rate 7.5 %

Share-Based Compensation (Table

Share-Based Compensation (Tables)	12 Months Ended
	Dec. 31, 2022
Share-Based Payment Arrangement [Abstract]
Summary of Stock Option Activity	The following table summarizes the stock option activity during the year ended December 31, 2022: Shares Weighted Average Weighted Average Aggregate Outstanding, January 1, 2022 1,749,876 $ 20.71 8.48 $ 10,007 Granted 1,583,038 15.28 Exercised (132,084) 3.04 Expired/cancelled (210,407) 20.61 Outstanding as of December 31, 2022 2,990,423 $ 19.28 8.59 $ 2,849 Options exercisable as of December 31, 2022 722,198 $ 18.53 6.84 $ 2,251 Vested and expected to vest as of December 31, 2022 2,990,423 $ 19.28 8.59 $ 2,849
Summary of Recognized Compensation Cost Related to Employee and Non-employee Stock-Based Compensation Activity	The Company recognized the following compensation cost related to employee and non-employee share-based compensation activity for the periods presented (amounts in thousands): Year Ended December 31, 2022 2021 Selling, general and administrative $ 6,333 $ 1,449 Research and development 3,310 657 Total $ 9,643 $ 2,106
Stock Options Valuation Assumptions	The calculation was based on the following assumptions: Year Ended December 31, 2022 2021 Weighted average grant date fair value (per share) $12.20 $18.88 Risk-free interest rate 1.46% - 4.23% 0.84% - 1.38% Expected volatility 85.91% - 89.35% 85.21% - 87.88% Expected term (in years) 5.5 - 6.1 5.1 - 6.3 Expected dividend yield — —

Employee Stock Purchase Plan (T

Employee Stock Purchase Plan (Tables)	12 Months Ended
	Dec. 31, 2022
Share-Based Payment Arrangement [Abstract]
Schedule of Share-Based Payment Award, Employee Stock Purchase Plan, Valuation Assumptions	The calculation was based on the following assumptions: Year Ended Strike price (per share) $11.40 - $11.66 Risk-free interest rate 1.54% - 4.40% Expected volatility 92.59% - 105.68% Expected term (in years) 0.5 Expected dividend yield —

Income Taxes (Tables)

Income Taxes (Tables)	12 Months Ended
	Dec. 31, 2022
Income Tax Disclosure [Abstract]
Schedule of Reconciliation of Statutory Federal Income Tax	A reconciliation of the statutory federal income tax with the provision for income taxes are as follows: Year Ended December 31, 2022 2021 Federal tax at statutory rate 21.0 % 21.0 % State income tax, net of federal benefit 1.8 0.5 Nondeductible interest — (0.1) Other permanent items (0.1) 0.4 Officers Compensation (1.7) — Nondeductible impairment — (13.8) Research credit 2.4 0.9 Change in valuation allowance (23.4) (8.9) Effective tax rate — % — %
Schedule of Significant Components of Deferred Tax Assets and Liabilities	Significant components of the Company’s deferred tax assets and liabilities are as follows (amounts in thousands): As of December 31, 2022 2021 Deferred tax assets: Net operating loss carryforwards $ 38,548 $ 34,228 Research and development tax credits 5,168 3,732 Section 174 capitalized research expense 5,417 — Other 4,219 1,214 Total deferred tax assets 53,352 39,174 Valuation allowance (52,766) (38,410) Total gross deferred tax assets, net of valuation allowance 586 764 Deferred tax liabilities: Other (586) (764) Total gross deferred tax liabilities (586) (764) Net deferred tax assets / (liabilities) $ — $ —
Summary of Changes to Gross Unrecognized Tax Benefits	The following table summarizes the changes to the Company’s gross unrecognized tax benefits for the years ended December 31, 2022 and 2021 (amounts in thousands): As of December 31, 2022 2021 Balance at the beginning of year $ 2,674 $ 2,404 Decrease related to prior year positions 2 (24) Increase related to current year positions 704 294 Balance at the end of year $ 3,380 $ 2,674

Nature of Organization and Op_2

Nature of Organization and Operations (Detail)				12 Months Ended
	Sep. 26, 2022 USD ($) $ / shares shares	Mar. 17, 2022 USD ($)	Aug. 26, 2021 USD ($) $ / shares shares	Dec. 31, 2022 USD ($) $ / shares shares	Dec. 31, 2021 USD ($) shares	Oct. 31, 2019 $ / shares shares
Organization Consolidation And Presentations Of Financial Statements [Line Items]
Issuance of common stock (in shares)			2,558,218
Preferred stock | $				$ 0	$ 0
Anniversary effective term period			20 years
Aggregate proceeds from issuance of common stock | $				$ 0	$ 155,000,000
Common stock, shares outstanding (in shares)			2,500,000	24,435,007	20,894,695
Number of warrants issued to purchase common stock (in shares)						40,000
Warrants exercise price (in dollars per share) | $ / shares						$ 7.29
Deferred offering costs paid for financing | $				$ 322,000	$ 9,617,000
Accumulated deficit | $				(203,198,000)	(142,685,000)
Net loss | $				(60,513,000)	$ (110,090,000)
Cash, cash equivalents, and short-term investments | $				$ 172,600,000
PIPE Investors
Organization Consolidation And Presentations Of Financial Statements [Line Items]
Ownership percentage on common stock			55.60%
PIPE Investors | Common Stock
Organization Consolidation And Presentations Of Financial Statements [Line Items]
Issuance of common stock (in shares)				3,374,000	11,853,000
Former Shareholders Of Aadi
Organization Consolidation And Presentations Of Financial Statements [Line Items]
Ownership percentage on common stock			29.20%
Former Stockholders of Aerpio Upon Merger
Organization Consolidation And Presentations Of Financial Statements [Line Items]
Ownership percentage on common stock			15.20%
Former Stockholders of Aerpio Upon Merger | Common Stock
Organization Consolidation And Presentations Of Financial Statements [Line Items]
Issuance of common stock (in shares)					3,209,000
Purchase Agreement | Private Placement Financing
Organization Consolidation And Presentations Of Financial Statements [Line Items]
Issuance of common stock (in shares)	3,373,526
Aggregate proceeds from issuance of common stock | $	$ 72,200,000
Sale of stock (in dollars per share) | $ / shares	$ 12.50
Warrant ownership limit	4.99%
Warrant ownership increase or decrease limit	19.99%
Warrant notice limit	61 days
Deferred offering costs paid for financing | $	$ 300,000
Purchase Agreement | Private Placement Financing | Pre-Funded Warrant
Organization Consolidation And Presentations Of Financial Statements [Line Items]
Sale of stock (in dollars per share) | $ / shares	$ 12.4999
Number of warrants issued to purchase common stock (in shares)	2,426,493			2,426,493
Warrants exercise price (in dollars per share) | $ / shares	$ 0.0001			$ 0.0001
Sales Agreement
Organization Consolidation And Presentations Of Financial Statements [Line Items]
Issuance of common stock (in shares)				0
Sales Agreement | Cowen and Company LLC | Common Stock
Organization Consolidation And Presentations Of Financial Statements [Line Items]
Issuance of common stock (in shares)				0
Maximum aggregate offering prices | $		$ 75,000,000
Merger Agreement
Organization Consolidation And Presentations Of Financial Statements [Line Items]
Reverse stock split ratio			15
Exchange ration of shares of common stock			0.3172
Issuance of common stock (in shares)			5,776,660
Estimated fair value consideration | $			$ 110,388,558
Number of common stock issued under purchase consideration (in shares)			3,208,718
Business acquisition, common stock per share (in dollars per share) | $ / shares			$ 33
Percentage of cumulative dividend on preferred stock			4%
Preferred stock | $			$ 4,400,000
Merger Agreement | Private Investment in Public Equity
Organization Consolidation And Presentations Of Financial Statements [Line Items]
Common stock, shares outstanding (in shares)			20,800,000
Merger Agreement | Subscription Agreements | Private Investment in Public Equity
Organization Consolidation And Presentations Of Financial Statements [Line Items]
Issuance of common stock (in shares)			11,852,862
Aggregate proceeds from issuance of common stock | $			$ 155,000,000
Aggregate net proceeds from issuance of common stock | $			$ 145,400,000

Summary of Significant Accoun_4

Summary of Significant Accounting Policies - Narrative (Detail)		12 Months Ended
	Aug. 26, 2021 USD ($) $ / shares shares	Dec. 31, 2022 USD ($) segment $ / shares shares	Dec. 31, 2021 USD ($) $ / shares shares	Sep. 26, 2022 $ / shares shares	Oct. 31, 2019 $ / shares shares
Summary Of Significant Accounting Policies [Line Items]
Capital stock held (in shares) | shares	8,100,000
Common stock, shares outstanding (in shares) | shares	2,500,000	24,435,007	20,894,695
Common stock, shares authorized (in shares) | shares	300,000,000	300,000,000	300,000,000
Common stock, par value (in dollars per share) | $ / shares	$ 0.0001	$ 0.0001	$ 0.0001
Number of operating segment | segment		1
Cash and cash equivalents | $		$ 39,019,000	$ 148,989,000
Convertible promissory notes outstanding | $		0	0
Allowance for doubtful accounts | $		$ 100,000	0
Estimated useful life of intangible assets		14 years 3 months 18 days
Intangible asset | $	$ 3,900,000	$ 0	3,900,000
Stock plan offering period		6 months
Number of warrants issued to purchase common stock (in shares) | shares					40,000
Warrants exercise price (in dollars per share) | $ / shares					$ 7.29
Conversion notes converted into common stock (in shares) | shares	698,018	698,018
Private Placement Financing | Purchase Agreement | Pre-Funded Warrant
Summary Of Significant Accounting Policies [Line Items]
Number of warrants issued to purchase common stock (in shares) | shares		2,426,493		2,426,493
Warrants exercise price (in dollars per share) | $ / shares		$ 0.0001		$ 0.0001
Product Sales Allowance
Summary Of Significant Accounting Policies [Line Items]
Deduction from gross product sales for allowances | $		$ 2,438,000
Minimum
Summary Of Significant Accounting Policies [Line Items]
Property and equipment estimated useful lives		3 years
Maximum
Summary Of Significant Accounting Policies [Line Items]
Property and equipment estimated useful lives		5 years
Term of options granted		10 years
Money Market Investments
Summary Of Significant Accounting Policies [Line Items]
Cash and cash equivalents | $		$ 32,000,000	$ 140,000,000
Company One | Revenue Benchmark | Customer Concentration Risk
Summary Of Significant Accounting Policies [Line Items]
Percentage of revenue		58%
Company Two | Revenue Benchmark | Customer Concentration Risk
Summary Of Significant Accounting Policies [Line Items]
Percentage of revenue			41%
Customer One | Accounts Receivable | Customer Concentration Risk
Summary Of Significant Accounting Policies [Line Items]
Percentage of revenue		100%

Summary of Significant Accoun_5

Summary of Significant Accounting Policies - Schedule of Cash, Cash Equivalents and Restricted Cash (Details) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Accounting Policies [Abstract]
Cash and cash equivalents	$ 39,019	$ 148,989
Restricted cash, non-current	64	0
Total cash, cash equivalents and restricted cash	$ 39,083	$ 148,989	$ 4,455

Summary of Significant Accoun_6

Summary of Significant Accounting Policies - Schedule of Inventory (Details) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Accounting Policies [Abstract]
Raw materials	$ 944
Work in process	0
Finished goods	917
Total	$ 1,861	$ 0

Summary of Significant Accoun_7

Summary of Significant Accounting Policies - Property and Equipment (Details) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Property, Plant and Equipment [Line Items]
Property and equipment, gross	$ 609	$ 87
Accumulated depreciation	(101)	(30)
Property and equipment, net	508	57
Computers and software
Property, Plant and Equipment [Line Items]
Property and equipment, gross	338	51
Construction in process
Property, Plant and Equipment [Line Items]
Property and equipment, gross	77	0
Furniture and fixtures
Property, Plant and Equipment [Line Items]
Property and equipment, gross	65	36
Leasehold improvements
Property, Plant and Equipment [Line Items]
Property and equipment, gross	$ 129	$ 0

Summary of Significant Accoun_8

Summary of Significant Accounting Policies - Gross-to-Net Sales Adjustments (Details) - Product Sales Allowance $ in Thousands	12 Months Ended
	Dec. 31, 2022 USD ($)
SEC Schedule, 12-09, Movement in Valuation Allowances and Reserves [Roll Forward]
Balance at Beginning of Year	$ 0
Provision for Current Period Sales	2,438
Payments	(1,004)
Balance at End of Year	$ 1,434

Summary of Significant Accoun_9

Summary of Significant Accounting Policies - Schedule of Outstanding Potentially Dilutive Securities Excluded in Calculation of Diluted Net Loss per Share (Detail) - shares	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Options to purchase common stock
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Total amount of anti-dilutive securities excluded from computation of earnings per share	2,990,423	1,749,876
Warrants to purchase common stock
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Total amount of anti-dilutive securities excluded from computation of earnings per share	29,167	36,667

Fair Value Measurement - Asset

Fair Value Measurement - Asset and Liabilities Measured on Recurring Basis (Details) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value	$ 165,576
Fair Value, Measurements, Recurring
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value	165,576
Money market funds
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value	32,035
Money market funds | Fair Value, Measurements, Recurring
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value	32,035	$ 140,032
U.S. government treasury bills
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value	70,708
U.S. government treasury bills | Fair Value, Measurements, Recurring
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value	70,708
Commercial paper
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value	53,296
Commercial paper | Fair Value, Measurements, Recurring
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value	53,296
Corporate bonds
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value	4,250
Corporate bonds | Fair Value, Measurements, Recurring
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value	4,250
Government agency
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value	5,287
Government agency | Fair Value, Measurements, Recurring
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value	5,287
Level 1 | Fair Value, Measurements, Recurring
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value	102,743
Level 1 | Money market funds | Fair Value, Measurements, Recurring
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value	32,035	140,032
Level 1 | U.S. government treasury bills | Fair Value, Measurements, Recurring
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value	70,708
Level 1 | Commercial paper | Fair Value, Measurements, Recurring
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value	0
Level 1 | Corporate bonds | Fair Value, Measurements, Recurring
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value	0
Level 1 | Government agency | Fair Value, Measurements, Recurring
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value	0
Level 2 | Fair Value, Measurements, Recurring
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value	62,833
Level 2 | Money market funds | Fair Value, Measurements, Recurring
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value	0	0
Level 2 | U.S. government treasury bills | Fair Value, Measurements, Recurring
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value	0
Level 2 | Commercial paper | Fair Value, Measurements, Recurring
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value	53,296
Level 2 | Corporate bonds | Fair Value, Measurements, Recurring
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value	4,250
Level 2 | Government agency | Fair Value, Measurements, Recurring
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value	5,287
Level 3 | Fair Value, Measurements, Recurring
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value	0
Level 3 | Money market funds | Fair Value, Measurements, Recurring
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value	0	$ 0
Level 3 | U.S. government treasury bills | Fair Value, Measurements, Recurring
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value	0
Level 3 | Commercial paper | Fair Value, Measurements, Recurring
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value	0
Level 3 | Corporate bonds | Fair Value, Measurements, Recurring
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value	0
Level 3 | Government agency | Fair Value, Measurements, Recurring
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Fair Value	$ 0

Fair Value Measurement - Narrat

Fair Value Measurement - Narrative (Details) - USD ($)		12 Months Ended
	Aug. 26, 2021	Dec. 31, 2022	Dec. 31, 2021
Fair Value Disclosures [Abstract]
Unrealized losses for cash equivalents and investments		$ 134,000
Impairment of acquired contract intangible asset	$ 74,200,000	3,724,000	$ 74,156,000
Intangible asset	$ 3,900,000	$ 0	$ 3,900,000

Short-Term Investments and Ca_3

Short-Term Investments and Cash and Cash Equivalents (Details) $ in Thousands	Dec. 31, 2022 USD ($)
Debt Securities, Available-for-Sale [Line Items]
Amortized Cost	$ 165,691
Unrealized Gains	19
Unrealized Losses	(134)
Fair Value	165,576
Money market funds
Debt Securities, Available-for-Sale [Line Items]
Amortized Cost	32,035
Unrealized Gains	0
Unrealized Losses	0
Fair Value	32,035
U.S. government treasury bills
Debt Securities, Available-for-Sale [Line Items]
Amortized Cost	70,812
Unrealized Gains	4
Unrealized Losses	(108)
Fair Value	70,708
Commercial paper
Debt Securities, Available-for-Sale [Line Items]
Amortized Cost	53,296
Unrealized Gains	0
Unrealized Losses	0
Fair Value	53,296
Corporate bonds
Debt Securities, Available-for-Sale [Line Items]
Amortized Cost	4,276
Unrealized Gains	0
Unrealized Losses	(26)
Fair Value	4,250
Government agency
Debt Securities, Available-for-Sale [Line Items]
Amortized Cost	5,272
Unrealized Gains	15
Unrealized Losses	0
Fair Value	$ 5,287

Merger - Additional Information

Merger - Additional Information (Details) - Merger Agreement	Aug. 26, 2021 USD ($) shares
Business Acquisition [Line Items]
Estimated fair value consideration | $	$ 110,388,558
Number of common stock issued under purchase consideration (in shares) | shares	3,208,718

Merger - Schedule of Estimated

Merger - Schedule of Estimated Fair Value Consideration (Detail) - Merger Agreement	Aug. 26, 2021 USD ($) $ / shares shares
Business Acquisition [Line Items]
Number of common shares of the combined company to be owned by Aerpio shareholders (in shares) | shares	3,208,718
Multiplied by the fair value per share of Aerpio common stock on August 26, 2021 (in dollars per share) | $ / shares	$ 33
Fair value of Aerpio common stock	$ 105,887,694
Aadi transaction costs	4,500,864
Purchase price	$ 110,388,558

Merger - Summary of Allocation

Merger - Summary of Allocation of Purchase Price (Detail) - Merger Agreement $ in Thousands	Aug. 26, 2021 USD ($)
Business Acquisition [Line Items]
Cash and cash equivalents	$ 29,700
Other current assets	2,709
Intangible asset	78,062
Deposits	20
Accounts payable and accrued liabilities	(103)
Purchase price	$ 110,388

Intangible Asset - Narrative (D

Intangible Asset - Narrative (Details) - USD ($)		12 Months Ended
	Aug. 26, 2021	Dec. 31, 2022	Dec. 31, 2021
Goodwill and Intangible Assets Disclosure [Abstract]
Impairment of acquired contract intangible asset	$ 74,200,000	$ 3,724,000	$ 74,156,000
Intangible asset	$ 3,900,000	$ 0	3,900,000
Percentage of future net cash proceeds will be remitted to CVR Holders		90%
Estimated useful life of intangible assets		14 years 3 months 18 days
Amortization expense		$ 87,000	$ 95,000

Intangible Asset - Summary of E

Intangible Asset - Summary of Estimated Amortization Expense Related to Definite Lived Intangible Asset (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Finite-Lived Intangible Assets [Roll Forward]
Intangible asset, net, beginning of year	$ 3,811	$ 0
Additions	0	78,062
Amortization	(87)	(95)
Impairment of contract intangible	(3,724)	(74,156)
Intangible asset, net, end of year	$ 0	$ 3,811
Impairment, Intangible Asset, Finite-Lived, Statement of Income or Comprehensive Income [Extensible Enumeration]	Intangible asset, net

Accrued Liabilities - Schedule

Accrued Liabilities - Schedule of Accrued Liabilities (Detail) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Accrued Liabilities, Current [Abstract]
Accrued bonus	$ 5,463	$ 1,465
Accrued clinical	2,399	2,507
Accrued professional fees	1,814	1,948
Advanced customer payments	1,571	0
Accrued salaries and payroll	1,299	152
Accrued contract manufacturing	405	2,287
Accrued other - sales related	1,435	0
Accrued other	536	344
Total accrued liabilities	$ 14,922	$ 8,703

Operating Lease - Narrative (De

Operating Lease - Narrative (Detail)	1 Months Ended
	Apr. 30, 2022	Aug. 31, 2021	Apr. 30, 2019
Los Angeles, California
Lessee Lease Description [Line Items]
Operating lease, agreement term			28 months
Operating lease, rent abatement period		9 months	4 months
Operating lease, lease amendment term		3 years
Operating lease, extend the term for an additional period		3 years 6 months
Morristown, New Jersey
Lessee Lease Description [Line Items]
Operating lease, agreement term	73 months
Operating lease, rent abatement period	3 months
Operating lease, rent escalation percentage	2%

Operating Lease - Summary of In

Operating Lease - Summary of Information Related to Lease (Detail) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Assets:
Operating lease right-of-use assets	$ 1,522	$ 557
Liabilities:
Operating lease liabilities, current portion	394	131
Operating lease liabilities, non-current	1,267	474
Total operating lease liabilities	$ 1,661	$ 605

Operating Lease - Schedule of R

Operating Lease - Schedule of Rent Expense (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Leases [Abstract]
Operating lease rent expense	$ 382	$ 188
Cash paid included in operating cash flows	$ 291	$ 129

Operating Lease - Summary of Fu

Operating Lease - Summary of Future Minimum Lease Payments Required under Operating Lease (Detail) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Future Minimum Lease Payments:
2023	$ 500
2024	512
2025	320
2026	231
2027	280
Thereafter	110
Total minimum lease payments	1,953
Less: amount representing interest	(292)
Total operating lease liabilities	1,661	$ 605
Less: operating lease liabilities, current	(394)	(131)
Operating lease liabilities, non-current	$ 1,267	$ 474
Weighted average remaining lease term (in years)	4 years 6 months 10 days
Weighted average incremental borrowing rate	7.50%

License Agreements (Detail)

License Agreements (Detail) - USD ($)		1 Months Ended	12 Months Ended
	Aug. 30, 2021	Jan. 31, 2021	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Capitalized Contract Cost [Line Items]
Royalties on net product sales			$ 1,100,000
Royalties accrued on product sales			400,000
Due to licensor			5,757,000	$ 5,757,000
Total revenue			$ 15,216,000	1,120,000	$ 14,000,000
Right to terminate the agreement			120 days
Upfront payment		$ 14,000,000	$ 14,000,000
Amount of certain development, regulatory, and sales milestones payments eligible to receive under license agreement.			257,000,000
BMS License Agreement
Capitalized Contract Cost [Line Items]
Payment of license fees	$ 5,800,000
Related party transaction, balloon payment interest rate per annum	4%
BMS License Agreement | EOC Pharma (Hong Kong) Limited
Capitalized Contract Cost [Line Items]
Due to licensor				2,800,000
Payment received from license agreement		$ 14,000,000
Sublicense fees, percentage		20%
License expense recognized				2,800,000
Total revenue				1,000,000
BMS License Agreement
Capitalized Contract Cost [Line Items]
Payments related to milestone			$ 0	0
License fees, percentage of previously outstanding payment obligation	50%
Due to licensor	$ 5,800,000
BMS License Agreement | EOC Pharma (Hong Kong) Limited
Capitalized Contract Cost [Line Items]
Payment of license fees				200,000
License expense recognized				$ 200,000

Convertible Notes (Detail)

Convertible Notes (Detail) - USD ($) $ / shares in Units, $ in Millions		1 Months Ended			12 Months Ended		13 Months Ended
	Aug. 26, 2021	Nov. 30, 2020	Jan. 31, 2020	Oct. 31, 2019	Dec. 31, 2022	Dec. 31, 2021	Oct. 31, 2020	May 31, 2021
Debt Disclosure [Abstract]
Proceeds from issuance of convertible notes			$ 1	$ 8.1
Convertible notes term		2 years					1 year
Convertible notes interest rate for fourth month date of loan agreement			6%	6%
Convertible notes interest rate for fifth and sixth month date of loan agreement			8%	8%
Convertible notes interest rate for remaining sixth months term until maturity at twelve months			10%	10%
Conversion into common stock, fixed conversion price per share (in dollars per share)								$ 4.80
Conversion notes converted into common stock (in shares)	698,018				698,018
Convertible promissory notes	$ 9.5
Gain on conversion						$ 0.4

Payroll Protection Program Lo_2

Payroll Protection Program Loan - Additional Information (Detail) - Small Business Administration (SBA), CARES Act, Payroll Protection Program (PPP) Loan - USD ($) $ in Millions		1 Months Ended
	Apr. 29, 2021	May 31, 2020
Payroll Protection Program Loan [Line Items]
Proceeds from approved loan		$ 0.2
Period after which debt instrument forgiven		168 days
Period for unforgiven debt payable		2 years
Debt instrument, interest rate for unforgiven debt		1%
Period for deferral payments of unforgiven debt		10 months
Principal Forgiveness
Payroll Protection Program Loan [Line Items]
Gain on debt forgiveness	$ 0.2

Stockholders' Equity (Deficit)

Stockholders' Equity (Deficit) (Detail)			1 Months Ended	12 Months Ended
	Sep. 26, 2022 USD ($) $ / shares shares	Aug. 26, 2021 USD ($) $ / shares shares	Mar. 31, 2022 USD ($)	Dec. 31, 2022 USD ($) vote $ / shares shares	Dec. 31, 2021 USD ($) $ / shares shares	Oct. 31, 2019 $ / shares shares	Dec. 31, 2018 shares	Mar. 31, 2018 $ / shares shares	Feb. 28, 2017 $ / shares shares	Feb. 23, 2017 shares	Dec. 31, 2016 $ / shares shares
Class Of Stock [Line Items]
Preferred stock, shares authorized (in shares)				10,000,000	10,000,000
Preferred stock, par value (in dollars per share) | $ / shares				$ 0.0001	$ 0.0001
Preferred stock, shares outstanding (in shares)				0	0
Preferred stock, shares issued (in shares)				0	0
Common stock, shares authorized (in shares)		300,000,000		300,000,000	300,000,000
Common stock, par value (in dollars per share) | $ / shares		$ 0.0001		$ 0.0001	$ 0.0001
Common stock, shares outstanding (in shares)		2,500,000		24,435,007	20,894,695
Issuance of common stock (in shares)		2,558,218
Proceeds from the issuance of common stock to PIPE Investors | $				$ 0	$ 155,000,000
Number of warrants issued to purchase common stock (in shares)						40,000
Warrants exercise price (in dollars per share) | $ / shares						$ 7.29
Deferred offering costs paid for financing | $				322,000	$ 9,617,000
Dividends common stock declared or paid | $				$ 0
Common stock, votes per share | vote				1
Sales Agreement
Class Of Stock [Line Items]
Issuance of common stock (in shares)				0
ATM offering price | $			$ 75,000,000
Merger Agreement
Class Of Stock [Line Items]
Issuance of common stock (in shares)		5,776,660
Private Investment in Public Equity | Merger Agreement
Class Of Stock [Line Items]
Common stock, shares outstanding (in shares)		20,800,000
Private Investment in Public Equity | Merger Agreement | Subscription Agreements
Class Of Stock [Line Items]
Issuance of common stock (in shares)		11,852,862
Proceeds from the issuance of common stock to PIPE Investors | $		$ 155,000,000
Aggregate net proceeds from issuance of common stock | $		$ 145,400,000
Private Placement Financing | Purchase Agreement
Class Of Stock [Line Items]
Issuance of common stock (in shares)	3,373,526
Proceeds from the issuance of common stock to PIPE Investors | $	$ 72,200,000
Sale of stock (in dollars per share) | $ / shares	$ 12.50
Deferred offering costs paid for financing | $	$ 300,000
Private Placement Financing | Purchase Agreement | Pre-Funded Warrant
Class Of Stock [Line Items]
Sale of stock (in dollars per share) | $ / shares	$ 12.4999
Number of warrants issued to purchase common stock (in shares)	2,426,493			2,426,493
Warrants exercise price (in dollars per share) | $ / shares	$ 0.0001			$ 0.0001
Series Seed Preferred Stock
Class Of Stock [Line Items]
Number of shares converted (in shares)										734,218
Series A Preferred Stock
Class Of Stock [Line Items]
Number of shares converted (in shares)							881,286				482,426
Preferred stock, issued price (in dollars per share) | $ / shares											$ 3.42
Convertible preferred stock, shares issued upon conversion percentage											85%
Series A Preferred Stock | Private Investment in Public Equity
Class Of Stock [Line Items]
Preferred stock, shares issued (in shares)								5,847,940	5,847,940
Preferred stock, issued price (in dollars per share) | $ / shares								$ 3.42	$ 3.42

Share-Based Compensation - Narr

Share-Based Compensation - Narrative (Detail) - USD ($) $ / shares in Units, $ in Thousands		1 Months Ended		12 Months Ended
	Aug. 26, 2021	May 31, 2022	Feb. 28, 2017	Dec. 31, 2022	Dec. 31, 2021	Jan. 01, 2023	Oct. 31, 2019
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Shares outstanding (in shares)				2,990,423	1,749,876
Aggregate intrinsic value of options outstanding				$ 2,849	$ 10,007
Weighted average grant date fair value (in dollars per share)				$ 12.20	$ 18.88
Intrinsic value of options exercised				$ 1,300	$ 1,000
Expense related to the acceleration of vesting associated with individual awards					$ 300
Vested and outstanding options, extended exercise ability (in shares)		64,436
Incremental share-based compensation expense				$ 300
Warrants outstanding (in shares)				29,167	36,666
Number of warrants issued to purchase common stock (in shares)							40,000
Warrants exercise price (in dollars per share)							$ 7.29
Number of warrants exercised (in shares)					7,500
Maximum
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Term of options granted				10 years
Private Aadi Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Common stock shares available for issuance				0
Vesting period			4 years
Shares outstanding (in shares)				299,039
Private Aadi Plan | Maximum
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Term of options granted			10 years
2011 Plan and 2017 Plan | Maximum
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Stock options or similar awards granted, assumed through merger (in shares)				0
2021 Equity Incentive Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Common stock shares available for issuance	2,070,784			853,760	1,390,606
Percentage applied to the outstanding shares as annual increase in number of shares authorized for issuance	4%
Shares outstanding (in shares)				2,590,360
Aggregate intrinsic value of options outstanding				$ 2,800
Weighted average grant date fair value (in dollars per share)				$ 12.20	$ 18.88
Unrecognized compensation cost related to stock options				$ 28,800
Weighted average period expected to be recognized				2 years 8 months 12 days
2021 Equity Incentive Plan | Subsequent Event
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Common stock shares available for issuance						977,400
2021 Equity Incentive Plan | Maximum
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Stock options or similar awards granted, assumed through merger (in shares)	764,154
Aerpio 2011 Equity Incentive Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Shares outstanding (in shares)				0
Aerpio 2017 Stock Option and Incentive Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Shares outstanding (in shares)				101,024

Share-Based Compensation - Summ

Share-Based Compensation - Summary of Stock Option Activity (Detail) - USD ($) $ / shares in Units, $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Shares
Shares, Outstanding at beginning balance (in shares)	1,749,876
Shares, Granted (in shares)	1,583,038
Shares, Exercised (in shares)	(132,084)
Shares, Expired/cancelled (in shares)	(210,407)
Shares, Outstanding at ending balance (in shares)	2,990,423	1,749,876
Shares, Options exercisable (in shares)	722,198
Weighted Average Exercise Price
Weighted Average Exercise Price, Outstanding at beginning balance (in dollars per share)	$ 20.71
Weighted Average Exercise Price, Granted (in dollars per share)	15.28
Weighted Average Exercise Price, Exercised (in dollars per share)	3.04
Weighted Average Exercise Price, Expired/cancelled (in dollars per share)	20.61
Weighted Average Exercise Price, Outstanding at ending balance (in dollars per share)	19.28	$ 20.71
Weighted Average Exercise Price, Options exercisable (in dollars per share)	$ 18.53
Weighted Average Remaining Contractual Term, Outstanding	8 years 7 months 2 days	8 years 5 months 23 days
Weighted Average Remaining Contractual Term, Options exercisable	6 years 10 months 2 days
Aggregate Intrinsic Value, Outstanding	$ 2,849	$ 10,007
Aggregate Intrinsic Value, Options exercisable	$ 2,251
Shares, Vested and expected to vest	2,990,423
Weighted Average Exercise Price, Vested and expected to vest (in dollars per share)	$ 19.28
Weighted Average Remaining Contractual Term, Vested and expected to vest	8 years 7 months 2 days
Aggregate Intrinsic Value, Vested and expected to vest	$ 2,849

Share-Based Compensation - Su_2

Share-Based Compensation - Summary of Recognized Compensation Cost Related to Employee and Non-employee Stock-Based Compensation Activity (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Share-based compensation expense	$ 9,643	$ 2,106
Selling, general and administrative
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Share-based compensation expense	6,333	1,449
Research and development
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Share-based compensation expense	$ 3,310	$ 657

Share-Based Compensation - Stoc

Share-Based Compensation - Stock Options Valuation Assumptions (Detail) - $ / shares	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Weighted average grant date fair value (in dollars per share)	$ 12.20	$ 18.88
Expected dividend yield	0%	0%
Minimum
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Risk-free interest rate	1.46%	0.84%
Expected volatility	85.91%	85.21%
Expected term (in years)	5 years 6 months	5 years 1 month 6 days
Maximum
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Risk-free interest rate	4.23%	1.38%
Expected volatility	89.35%	87.88%
Expected term (in years)	6 years 1 month 6 days	6 years 3 months 18 days

Employee Stock Purchase Plan -

Employee Stock Purchase Plan - Narrative (Details) - USD ($) $ in Thousands		12 Months Ended
	Aug. 17, 2021	Dec. 31, 2022	Dec. 31, 2021	Jan. 01, 2023
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Stock plan offering period		6 months
Employee Stock Purchase Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Maximum employee contribution	15%
Offering period	6 months
Purchase price percent of shares	85%
Common stock shares available for issuance	519,563
Maximum number of shares provided for issuance	310,617
Percentage of annual increase in number of shares reserved for issuance	1%
Common stock available for issuance (in shares)		492,361	310,617
Employee stock purchase plan liability		$ 76	$ 0
Issuance of shares under the employee stock purchase plan (in shares)		27,202	0
Employee Stock Purchase Plan | Subsequent Event
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Common stock shares available for issuance				244,350

Employee Stock Purchase Plan _2

Employee Stock Purchase Plan - Calculation Assumptions (Details) - $ / shares	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Expected dividend yield	0%	0%
Minimum
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Expected term (in years)	5 years 6 months	5 years 1 month 6 days
Maximum
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Expected term (in years)	6 years 1 month 6 days	6 years 3 months 18 days
Employee Stock Purchase Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Risk-free interest rate, Minimum	1.54%
Risk-free interest rate, Maximum	4.40%
Expected volatility, Minimum	92.59%
Expected volatility, Maximum	105.68%
Expected term (in years)	6 months
Expected dividend yield	0%
Employee Stock Purchase Plan | Minimum
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Strike price (per share)	$ 11.40
Employee Stock Purchase Plan | Maximum
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Strike price (per share)	$ 11.66

Income Taxes - Narrative (Detai

Income Taxes - Narrative (Detail) - USD ($)	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Income Tax Disclosure [Line Items]
Income tax expense	$ 0	$ 2,000
Increase in valuation allowance	14,400,000	$ 28,200,000
Penalties related to income tax matters	0
Accrued interest related to income tax matters	$ 0
Net operating loss, carryback period due to CARES Act	5 years
Federal
Income Tax Disclosure [Line Items]
Operating loss carryforwards	$ 167,500,000
Operating loss carryforwards, carried forward indefinitely	123,400,000
Federal | Research and Development
Income Tax Disclosure [Line Items]
Tax credit carryforwards	5,000,000
State
Income Tax Disclosure [Line Items]
Operating loss carryforwards	72,000,000
Operating loss carryforwards, carried forward indefinitely	16,500,000
State | Research and Development
Income Tax Disclosure [Line Items]
Tax credit carryforwards	$ 2,300,000

Income Taxes - Schedule of Reco

Income Taxes - Schedule of Reconciliation of Statutory Federal Income Tax (Detail)	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Income Tax Disclosure [Abstract]
Federal tax at statutory rate	21%	21%
State income tax, net of federal benefit	1.80%	0.50%
Nondeductible interest	0%	(0.10%)
Other permanent items	(0.10%)	0.40%
Officers Compensation	(1.70%)	0%
Nondeductible impairment	0%	(13.80%)
Research credit	2.40%	0.90%
Change in valuation allowance	(23.40%)	(8.90%)
Effective tax rate	0%	0%

Income Taxes - Schedule of Sign

Income Taxes - Schedule of Significant Components of Deferred Tax Assets and Liabilities (Detail) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Deferred tax assets:
Net operating loss carryforwards	$ 38,548	$ 34,228
Research and development tax credits	5,168	3,732
Section 174 capitalized research expense	5,417	0
Other	4,219	1,214
Total deferred tax assets	53,352	39,174
Valuation allowance	(52,766)	(38,410)
Total gross deferred tax assets, net of valuation allowance	586	764
Deferred tax liabilities:
Other	(586)	(764)
Total gross deferred tax liabilities	(586)	(764)
Net deferred tax assets / (liabilities)	$ 0	$ 0

Income Taxes - Summary of Chang

Income Taxes - Summary of Changes to Gross Unrecognized Tax Benefits (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Reconciliation of Unrecognized Tax Benefits, Excluding Amounts Pertaining to Examined Tax Returns [Roll Forward]
Balance at the beginning of year	$ 2,674	$ 2,404
Decrease related to prior year positions	2
Decrease related to prior year positions		(24)
Increase related to current year positions	704	294
Balance at the end of year	$ 3,380	$ 2,674

Commitments and Contingencies -

Commitments and Contingencies - Additional Information (Detail) - USD ($)	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Commitments and Contingencies Disclosure [Abstract]
Accrued clinical and contract manufacturing expense	$ 2,800,000	$ 4,800,000
Purchase commitments to be paid in 2023	1,900,000
Incurred collaboration and supply agreement expense	$ 0

Employee Retirement Plan (Detai

Employee Retirement Plan (Details) - USD ($)	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Retirement Benefits [Abstract]
Discretionary contributions	$ 500,000	$ 0