Amarantus BioScience (AMBS) 10-Q 1 Jun 16 2016 Q1 Quarterly report Financial data

Document and Entity Information

Document and Entity Information - shares	3 Months Ended
	Mar. 31, 2016	May. 25, 2016
Document and Entity Information [Abstract]
Entity Registrant Name	Amarantus Bioscience Holdings, Inc.
Entity Central Index Key	1,424,812
Amendment Flag	false
Current Fiscal Year End Date	--12-31
Document Type	10-Q
Document Period End Date	Mar. 31, 2016
Document Fiscal Year Focus	2,016
Document Fiscal Period Focus	Q1
Entity Filer Category	Smaller Reporting Company
Entity Common Stock, Shares Outstanding		68,272,000

Condensed Consolidated Balance

Condensed Consolidated Balance Sheets (Unaudited) - USD ($) $ in Thousands	Mar. 31, 2016	Dec. 31, 2015
Current assets:
Cash and cash equivalents	$ 100	$ 176
Related party convertible notes receivable at fair value	500
Prepaid expenses and other current assets	342	$ 567
Total current assets	942	743
Non-current assets:
Property and equipment, net	95	115
Intangible assets	2,861	2,861
Goodwill	7,967	7,967
Total non-current assets	10,923	10,943
TOTAL ASSETS	11,865	11,686
Current liabilities:
Accounts payable and accrued liabilities	7,620	7,723
Related party liabilities and accrued interest	258	257
Accrued interest	322	195
Notes payable (net of deferred financing cost of $0 and $3 as of March 31, 2016 and December 31, 2015, respectively)	600	997
Senior secured convertible notes payable (net of debt discount of $2,963 and $3,854, and deferred financing cost of $0 and $82 as of March 31, 2016 and December 31, 2015, respectively)	2,389	1,316
Derivative liability	4,165	5,098
Share-settled debt	476	521
Total current liabilities	15,830	16,107
Deferred tax liability	1,113	1,113
Total liabilities	$ 16,943	$ 17,220
Temporary equity carrying amount
COMMITMENTS AND CONTINGENCIES
STOCKHOLDERS' EQUITY (DEFICIT):
Convertible preferred stock
Common stock, $0.001 par value, 150,000,000 authorized; 57,640,958 and 21,177,353 shares issued and outstanding at March 31, 2016 and December 31, 2015, respectively	$ 58	$ 21
Additional paid-in capital	78,985	74,767
Accumulated deficit	(104,873)	(92,241)
Total stockholders' equity (deficit)	(25,829)	(8,688)
TOTAL LIABILITIES AND STOCKHOLDERS' EQUITY (DEFICIT) AND TEMPORARY EQUITY	$ 11,865	$ 11,686
Series A Preferred Stock
STOCKHOLDERS' EQUITY (DEFICIT):
Convertible preferred stock
Series B Preferred Stock
STOCKHOLDERS' EQUITY (DEFICIT):
Convertible preferred stock
Series C Preferred Stock
STOCKHOLDERS' EQUITY (DEFICIT):
Convertible preferred stock	$ 1	$ 1
Series E Preferred Stock
Current liabilities:
Temporary equity carrying amount	$ 10,774
STOCKHOLDERS' EQUITY (DEFICIT):
Convertible preferred stock		$ 8,764
Series H Preferred Stock
Current liabilities:
Temporary equity carrying amount	$ 9,977	$ 3,154

Condensed Consolidated Balance3

Condensed Consolidated Balance Sheets (Unaudited) (Parenthetical) - USD ($) $ in Thousands	Mar. 31, 2016	Dec. 31, 2015
Common stock, par value	$ 0.001	$ 0.001
Common stock, shares authorized	150,000,000	150,000,000
Common stock, shares issued	57,640,958	21,177,353
Common stock, shares outstanding	57,640,958	21,177,353
Net of deferred financing cost	$ 0	$ 3
Deferred financing cost	0	82
Net of debt discount	$ 2,963	$ 3,854
Convertible Preferred Stock
Preferred stock, par value	$ 0.001	$ 0.001
Preferred stock, shares authorized	10,000,000	10,000,000
Series A Preferred Stock
Preferred stock, par value	$ 0.001	$ 0.001
Preferred stock shares, designated	250,000	250,000
Preferred stock, shares issued	0	0
Preferred stock, shares outstanding	0	0
Series B Preferred Stock
Preferred stock, par value	$ 0.001	$ 0.001
Preferred stock shares, designated	3,000,000	3,000,000
Preferred stock, shares issued	0	0
Preferred stock, shares outstanding	0	0
Series C Preferred Stock
Preferred stock, par value	$ 0.001	$ 0.001
Preferred stock shares, designated	750,000	750,000
Preferred stock, shares issued	750,000	750,000
Preferred stock, shares outstanding	750,000	750,000
Series E Preferred Stock
Preferred stock, par value		$ 1,000
Preferred stock shares, designated		13,335
Preferred stock, shares issued		9,766
Preferred stock, shares outstanding		9,766
Series E Preferred Stock
Preferred stock, par value	$ 1,000
Preferred stock shares, designated	13,335
Preferred stock, shares issued	8,568
Preferred stock, shares outstanding	8,568
Preferred stock, liquidation preference, value	$ 10,774
Series H Preferred Stock
Preferred stock, par value	$ 1,000	$ 1,000
Preferred stock shares, designated	25,000	25,000
Preferred stock, shares issued	6,042	2,816
Preferred stock, shares outstanding	6,042	2,816
Preferred stock, liquidation preference, value	$ 9,977	$ 9,977

Condensed Consolidated Statemen

Condensed Consolidated Statements of Operations (Unaudited) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2016	Mar. 31, 2015
Income Statement [Abstract]
Net revenues:
Operating expenses:
Research and development	$ 1,357	$ 2,477
General and administrative	1,295	4,061
Total operating costs and expenses	2,652	6,538
Loss from operations	(2,652)	(6,538)
Other income (expense):
Interest Expense	(1,278)	$ (42)
Change in fair value of warrants & derivatives liabilities	2,459
Change in fair value of share-settled debt	20
Loss on extinguishment of convertible debt	(74)
Other expense	(51)
Total other income (expense)	1,076	$ (42)
Net loss	(1,576)	(6,580)
Dividends declared on convertible preferred stock	(749)	$ (828)
Deemed dividends on convertible preferred stock	(10,307)
Net loss applicable to common stockholders	$ (12,632)	$ (7,408)
Net loss per share applicable to common stockholders - basic and diluted	$ (0.37)	$ (1.02)
Weighted average shares used in computing basic and diluted loss per share	33,720,000	7,232,000

Condensed Consolidated Stateme5

Condensed Consolidated Statements Statement of Stockholders' Equity (Deficit) (Unaudited) - 3 months ended Mar. 31, 2016 - USD ($) $ in Thousands	Total	Convertible Preferred Stock	Common Stock	Additional Paid-in Capital	Accumulated Deficit
Beginning Balance at Dec. 31, 2015	$ (8,688)	$ 8,765	$ 21	$ 74,767	$ (92,241)
Beginning Balance, Shares at Dec. 31, 2015		759,766	21,177,353
Reclass Series E convertible stock to temporary equity	(8,764)	$ (8,764)
Reclass Series E convertible stock to temporary equity, Shares		(9,766)
Beneficial conversion feature of Series H convertible preferred stock	610			$ 610
Beneficial conversion feature of Series H convertible preferred stock, Shares
Deemed dividends related to immediate accretion of beneficial conversion feature of Series H convertible preferred stock	(610)				$ (610)
Deemed dividends related to immediate accretion of beneficial conversion feature of Series H convertible preferred stock, Shares
Common stock issued in conversion of Series H convertible preferred stock	1,354		$ 18	$ 1,336
Common stock issued in conversion of Series H convertible preferred stock, Shares			18,426,595
Deemed dividend on conversion of Series H convertible preferred stock to common stock	(923)				$ (923)
Deemed dividend on conversion of Series H convertible preferred stock to common stock, Shares
Deemed dividends related to repurchase of Series H convertible preferred stock	(259)				(259)
Deemed dividends related to accretion of redemption value of Series H convertible preferred stock	(5,095)				$ (5,095)
Deemed dividends related to accretion of redemption value of Series H convertible preferred stock, Shares
Common stock issued in conversion of Series E convertible preferred stock	1,205		$ 10	$ 1,195
Common stock issued in conversion of Series E convertible preferred stock, Shares			10,262,957
Deemed dividend on conversion of Series E convertible preferred stock to common stock	(130)				$ (130)
Deemed dividends related to repurchase of Series E convertible preferred stock	(153)				(153)
Deemed dividends related to accretion of redemption value of Series E convertible preferred stock	(3,137)				$ (3,137)
Deemed dividends related to accretion of redemption value of Series E convertible preferred stock, Shares
Common stock issued for note conversion	199		$ 3	$ 196
Common stock issued for note conversion, Shares			2,484,857
Common stock issued for accrued interest conversion	75		$ 1	74
Common stock issued for accrued interest conversion, Shares			1,326,192
Common Stock issued for Series E convertible preferred stock quarterly dividend	325		$ 2	323
Common Stock issued for Series E convertible preferred stock quarterly dividend, Shares			1,852,453
Common stock issued for Series H convertible preferred stock quarterly dividend	148		$ 2	$ 146
Common stock issued for Series H convertible preferred stock quarterly dividend, Shares			1,630,499
Series E dividend accrued	(601)				$ (601)
Series H dividend accrued	(148)				$ (148)
Common stock issued for services	218		$ 1	$ 217
Common stock issued for services, Shares			480,000
Stock-based compensation expense	161			161
Legal fees related to stock financing	$ (40)			$ (40)
Fractional shares related to rounding
Fractional shares related to rounding, Shares			52
Net loss	$ (1,576)				$ (1,576)
Ending Balance at Mar. 31, 2016	$ (25,829)	$ 1	$ 58	$ 78,985	$ (104,873)
Ending Balance, Shares at Mar. 31, 2016		750,000	57,640,958

Condensed Consolidated Stateme6

Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2016	Mar. 31, 2015
Cash flows from operating activities
Net loss	$ (1,576)	$ (6,580)
Adjustments to reconcile net loss to net cash used in operating activities
Depreciation and amortization	20	$ 19
Amortization of debt discount	961
Amortization of deferred financing fees	$ 85
Amortization of intangible assets		$ 32
Non-cash financing expense		$ 14
Loss on extinguishment of convertible debt	$ 74
Change in fair value of warrants and derivative liability	(2,459)
Change in fair value of share-settled debt	(20)
Common stock issued for services	218	$ 106
Stock-based compensation expense	161	488
Changes in assets and liabilities:
Prepaid expenses and other current assets	225	(62)
Accounts payable and accrued expenses	(304)	$ (1,851)
Related party liabilities and accrued interest	1
Accrued interest	127	$ 29
Net cash used in operating activities	$ (2,487)	(7,805)
Cash flows from investing activities
Acquisition of DioGenix, Inc, net of non-cash portion		$ (900)
Investment in convertible note receivable	$ (500)
Acquisition other assets		$ (1)
Net cash used in investing activities	$ (500)	(901)
Cash flows from financing activities
Proceeds from senior secured convertible promissory notes		2,850
Repayment of notes payable	$ (100)	0
Legal fees related to stock financing	$ (91)	(19)
Proceeds from issuance of common stock		2,820
Net cash provided by financing activities	$ 2,911	8,601
Net increase in cash and cash equivalents	(76)	(105)
Cash and cash equivalents, beginning of the year	176	214
Cash and cash equivalents, end of period	100	$ 109
Supplemental schedule of non-cash investing and financing activities:
Reclass Series E convertible preferred stock to temporary equity	8,764
Beneficial conversion feature of Series H convertible preferred stock	610
Deemed dividends related to immediate accretion of beneficial conversion feature of Series H convertible preferred stock	610
Fair Value of derivative liability common stock warrant issued with Series H convertible preferred stock	1,456
Series H preferred stock issued for note conversion	100
Debt discount associated with convertible promissory note - derivative liability	105
Reversal of unamortized debt discount related to debt conversion	(35)
Common stock issued for accrued interest conversion	75
Common stock issued for share-settled debt and convertible promissory notes conversion	125
Reclass between notes payable and senior convertible notes	$ 300
Common stock issued as fee for debt financing arrangement		$ 102
Series E Convertible Preferred Stock [Member]
Cash flows from financing activities
Sale of preferred stock	$ 230	$ 2,950
Repurchase of preferred stock	(384)
Supplemental schedule of non-cash investing and financing activities:
Common stock issued in conversion of preferred stock	1,205	$ 172
Deemed dividends on conversion of preferred stock to common stock	130
Deemed dividends on repurchase of preferred stock	27
Deemed dividends related to accretion of preferred stock redemption value	3,137
Series H Convertible Preferred Stock [Member]
Cash flows from financing activities
Sale of preferred stock	3,890
Repurchase of preferred stock	(634)
Supplemental schedule of non-cash investing and financing activities:
Common stock issued in conversion of preferred stock	1,354
Deemed dividends on conversion of preferred stock to common stock	923
Deemed dividends on repurchase of preferred stock	48
Deemed dividends related to accretion of preferred stock redemption value	$ 5,095
Series D preferred stock dividend [Member]
Supplemental schedule of non-cash investing and financing activities:
Common stock issued in conversion of preferred stock		$ 9
Stock issued for preferred quarterly dividend		35
Series preferred stock dividend accrued		15
Series E preferred stock dividend [Member]
Supplemental schedule of non-cash investing and financing activities:
Stock issued for preferred quarterly dividend	$ 325	237
Series preferred stock dividend accrued	601	$ 192
Series H preferred stock dividend [Member]
Supplemental schedule of non-cash investing and financing activities:
Stock issued for preferred quarterly dividend	148
Series preferred stock dividend accrued	$ 148

General

General	3 Months Ended
	Mar. 31, 2016
General [Abstract]
GENERAL	1. GENERAL Amarantus Bioscience Holdings, Inc. (“Amarantus” or the “Company”) is a California based biopharmaceutical company founded in January 2008. We own or have exclusive licenses to various product candidates in the biopharmaceutical and diagnostic areas of the healthcare industry. We are developing our diagnostic product candidates in the field of neurology, and our therapeutic product candidates in the areas of neurology, psychiatry, ophthalmology and regenerative medicine. Our business model is to develop our product candidates through various de-risking milestones that we believe will be accretive to shareholder value, and will position them to be strategically partnered with pharmaceutical companies, diagnostic companies and/or other stakeholders in order to more efficiently achieve regulatory approval and commercialization. Amarantus Bioscience has three operating divisions: the diagnostics division; the therapeutics division; and the drug discovery division. Basis of Presentation The accompanying unaudited condensed consolidated financial statements include the accounts of the Company and its wholly owned subsidiaries. All significant intercompany balances and transactions have been eliminated in consolidation. The unaudited condensed consolidated financial statements (Financial Statements) have been prepared by the Company pursuant to the rules and regulations of the Securities and Exchange Commission (the “SEC”) and reflect all adjustments (consisting of normal recurring adjustments unless otherwise indicated) which, in the opinion of management, are necessary for a fair presentation of the results for the interim periods presented. Certain prior year amounts have been reclassified to conform to current year presentation. Certain information in footnote disclosures normally included in the financial statements prepared in conformity with accounting principles generally accepted in the United States of America have been condensed or omitted pursuant to the SEC rules and regulations for interim reporting. The financial results for the periods presented may not be indicative of the full year’s results. The Company believes the disclosures are adequate to make the information presented not misleading. These financial statements should be read in conjunction with the Company’s audited consolidated financial statements and the notes thereto for the fiscal year ended December 31, 2015 included in the Company’s Annual Report on Form 10K filed in May 2016. Significant Accounting Policies There have been no material changes in the Company’s significant accounting policies to those previously disclosed in the 2015 Annual Report. Reclassification Use of Estimates Research and Development Expenditures Related Party, Fair Value Convertible Notes Receivable Recent Accounting Pronouncements In January 2016, FASB issued ASU 2016-01, Recognition and Measurement of Financial Assets and Financial Liabilities In February 2016, FASB issued ASU No. 2016-02, Leases (Topic 842) Leases (Topic 840) In March 2016, the FASB issued ASU No. 2016-09, Compensation – Stock Compensation (Topic 718): Improvements to Employee Share-Based Payment Accounting

Liquidity and Going Concern

Liquidity and Going Concern	3 Months Ended
	Mar. 31, 2016
Liquidity and Going Concern [Abstract]
LIQUIDITY AND GOING CONCERN	2. LIQUIDITY AND GOING CONCERN The Company’s activities since inception have consisted principally of acquiring product and technology rights, raising capital, and performing research and development. Successful completion of the Company’s development programs and, ultimately, the attainment of profitable operations are dependent on future events, including, among other things, its ability to access potential markets; secure financing, develop a customer base; attract, retain and motivate qualified personnel; and develop strategic alliances. From inception, the Company has been funded by a combination of equity and debt financings. Although management believes that the Company will be able to successfully fund its operations, there can be no assurance that the Company will be able to do so or that the Company will ever operate profitably. The Company’s activities since inception have consisted principally of acquiring product and technology rights, raising capital, and performing research and development. Historically, we have incurred net losses and negative cash flows from operations. The Company expects to continue to incur substantial losses over the next several years during its development phase. To fully execute its business plan, the Company will need to complete certain research and development activities and clinical studies. Further, the Company’s product candidates will require regulatory approval prior to commercialization. These activities may span many years and require substantial expenditures to complete and may ultimately be unsuccessful. Any delays in completing these activities could adversely impact the Company. The Company plans to meet its capital requirements primarily through issuances of debt and equity securities and, in the longer term, revenue from product sales. The accompanying financial statements have been prepared in conformity with accounting principles generally accepted in the United States of America (“GAAP”), which contemplate continuation of the Company as a going concern. Historically, the Company has incurred net losses and negative cash flows from operations. The Company believes its current capital resources are not sufficient to support its operations. Management intends to continue its research efforts and to finance operations of the Company through debt and/or equity financings. Management plans to seek additional debt and/or equity financing through private or public offerings or through a business combination or strategic partnership. There can be no assurance that the Company will be successful in obtaining additional financing on favorable terms, or at all. These matters raise substantial doubt about the Company’s ability to continue as a going concern. The financial statements do not include any adjustments that might result from the outcome of these uncertainties.

Net Loss Per Share

Net Loss Per Share	3 Months Ended
	Mar. 31, 2016
Net Loss Per Share [Abstract]
NET LOSS PER SHARE	3. NET LOSS PER SHARE The following table sets forth the computation of the basic and diluted net loss per share attributable to the Company’s common stockholders for the periods indicated (dollars in thousands, except per share amounts): For the three months ended March 31, 2016 2015 Numerator: Net loss $ (1,576 ) $ (6,580 ) Preferred stock dividend (749 ) (828 ) Deemed dividends on convertible preferred stock (10,307 ) - Net loss attributable to common stockholders $ (12,632 ) $ (7,408 ) Denominator: Common stock outstanding 33,720,000 7,232,000 Basic and diluted net loss per share $ (0.37 ) $ (1.02 ) Potentially dilutive securities consist of: For the three months ended March 31, 2016 2015 Outstanding common stock options 308,000 379,000 Outstanding preferred stock option 829,000 829,000 Common stock purchase warrants 52,839,000 306,000 Related party liability and accrued interest 5,159,000 34,000 Notes payable 10,060,000 - Convertible senior secured promissory notes and accrued interest 94,803,000 - Share-settled debt and accrued interest 6,936,000 - Convertible preferred stock Series C 5,000 5,000 Convertible preferred stock Series E 95,204,000 - Convertible preferred stock Series H 100,696,000 - Potentially dilutive securities 366,839,000 1,553,000 All of the listed dilutive securities are excluded from the computation of fully diluted loss per share as they are anti-dilutive.

Related Party Convertible Notes

Related Party Convertible Notes Receivable, At Fair Value	3 Months Ended
	Mar. 31, 2016
Related Party Convertible Notes Receivable, At Fair Value [Abstract]
RELATED PARTY CONVERTIBLE NOTES RECEIVABLE, AT FAIR VALUE	4. RELATED PARTY CONVERTIBLE NOTES RECEIVABLE, AT FAIR VALUE Notes receivable are stated at fair value, as the Company has elected to fair value its notes receivable using the fair value option permitted to the Company. The following is a summary of outstanding related party convertible notes receivable as of March 31, 2016 (amount in thousands): Stated Conversion Carrying Issue Date Maturity Date Interest Rate Terms Value Avant Diagnostics, Inc 3/7/2016 3/7/2017 12 % $ 0.20 $ 100,000 Theranostics Health, Inc 2/29/2016 2/28/2017 8 % $ 40.64 400,000 Ending balance as of March 31, 2016 $ 500,000 On March 1, 2016, the Company loaned $400,000 to Theranostic Health, Inc. (“THI”) which is evidenced by a convertible note issued by THI (the “THI Note”). The Company provided the financing evidenced by the Note in order to facilitate the proposed acquisition by Avant Diagnostics, Inc. (“Avant”) of the assets and certain liabilities of THI. In a concurrent transaction, the Company has entered into a non-binding letter of intent to sell its wholly-owned subsidiary, Amarantus Diagnostics, Inc. to Avant for 80 million shares of common stock of Avant. The THI Note matures on February 28, 2017 and bears interest at 8% per annum payable at maturity in cash. The THI Note is convertible at any time at the option of the Company into shares of common stock of THI at a conversion price of $40.64 per share. The THI Note shall automatically convert into shares of common stock of THI upon a change of control of THI. It is expected that the THI Note will be assumed by Avant upon consummation of the transaction with THI. The conversion price of the THI Note is subject to weighted average anti-dilution price protection if the dilutive issuances are for less than $1 million and full ratchet anti-dilution protection if the dilutive issuances are for more than $1 million. The THI Note has events of default in for any default in the payment of principal or interest when due and for bankruptcy. On March 7, 2016, the Company loaned $100,000 to Avant which is evidenced by a convertible note (the “Avant Note”). The Avant Note matures on March 7, 2017 and bears interest at 12% per annum payable at maturity in cash. The Avant Note is convertible at any time at the option of the Company into shares of common stock of Avant at a conversion price of $0.20 per share. The Avant Note shall automatically convert into shares of common stock of Avant upon a change of control of Avant.

Notes Payable

Notes Payable	3 Months Ended
	Mar. 31, 2016
Notes Payable / Senior Secured Convertible Promissory Notes [Abstract]
NOTE PAYABLE	5. NOTES PAYABLE On March 9, 2016 two investors assigned their 12% Promissory notes issued by the Company to a third investor. The third investor, on the same day, entered into two separate Exchange Agreements with the Company. The Exchange Agreements allow the third investor to exchange the 12% Promissory Notes for two separate 12% Senior Secured Convertible Promissory Notes in the principal amounts of $100,000 and $200,000 respectively. During the quarter ended March 31, 2016, the Company made payment of $100,000 on outstanding notes payable, and $30,000 on accrued interest. As of March 31, 2016, the Company had notes payable in the aggregate amount of $600,000 outstanding. The Company is in default under the terms of all of its outstanding notes payables.

Senior Secured Convertible Prom

Senior Secured Convertible Promissory Notes	3 Months Ended
	Mar. 31, 2016
Notes Payable / Senior Secured Convertible Promissory Notes [Abstract]
SENIOR SECURED CONVERTIBLE PROMISSORY NOTES	6. SENIOR SECURED CONVERTIBLE PROMISSORY NOTES The following is a summary of outstanding senior secured convertible notes as of March 31, 2016 (amount in thousands): Stated Accumulated Issue Maturity Interest Rate Conversion Face Value Debt Carrying Delafeild Investments Ltd 9/30/2015 9/29/2016 12 % $ 0.06 $ 3,056 $ (1,716 ) $ 1,340 Dominion Capital LLC 9/30/2015 9/29/2016 12 % $ 0.06 2,096 (1,177 ) 919 GEMG LLC 3/9/2016 7/1/2016 12 % $ 0.06 200 (70 ) 130 Ending balance as of March 31, 2016 $ 5,352 $ (2,963 ) $ 2,389 Dominion Notes During the quarter ended March 31, 2016, the Company entered into a conversion agreement with Dominion Capital for the conversion of an aggregate amount of $75,000 in accrued interest on notes issued to Dominion Capital to 1.3 million shares of common stock. Other Convertible Notes On March 9, 2016, an individual investor exchanged its note payable of $300,000 for 12% senior secured convertible notes. The Company recorded additional embedded conversion feature of $105,000 as debt discount on the issuance date. During March 2016, an outstanding $100,000 note was converted into 2.0 million shares of common stock, and the Company wrote off $35,000 debt discount associated with the note. The Company recorded a loss of $40,000 on the conversion based on the fair value of the common stock recorded. During the quarter ended March 31, 2016, the Company entered into a conversion agreement with an investor to covert an aggregate amount of $100,000 to 110 shares of Series H convertible preferred stock including a 10% OID. The Company is in default under the terms of all of its senior secured convertible promissory notes.

Share-Settled Debt

Share-Settled Debt	3 Months Ended
	Mar. 31, 2016
Share-Settled Debt [Abstract]
SHARE-SETTLED DEBT	7. SHARE-SETTLED DEBT During the quarter ended March 31, 2016, the Company converted $25,000 share-settled debt into 495,188 shares of common stock at $0.12 per share. The Company also recorded an extinguishment loss of $34,000 on the conversion. The Company is in default under the terms of its share-settled debt.

Fair Value Measurements

Fair Value Measurements	3 Months Ended
	Mar. 31, 2016
Fair Value Measurements [Abstract]
FAIR VALUE MEASUREMENTS	8. FAIR VALUE MEASUREMENTS The Company’s financial assets and liabilities that are measured at fair value on a recurring basis as of March 31, 2016 by level within the fair value hierarchy, are as follows (in thousands): Fair value measured at March 31, 2016 Fair value Quoted Significant Significant 2016 (Level 1) (Level 2) (Level 3) Assets: Related party convertible notes receivable $ 500 $ - $ - $ 500 Total fair value $ 500 $ - $ - $ 500 Liabilities: Embedded conversion feature $ 2,092 $ - $ - $ 2,092 Warrant liability 2,073 - - 2,073 Share-settled debt 476 - - 476 Total fair value $ 4,641 $ - $ - $ 4,641 There were no transfers between Level 1, 2 or 3 during the three months ended March 31, 2016. The following table presents additional information about Level 3 liabilities measured at fair value. Both observable and unobservable inputs may be used to determine the fair value of positions that the Company has classified within the Level 3 category. As a result, the unrealized gains and losses for assets and liabilities within the Level 3 category may include changes in fair value that were attributable to both observable (e.g., changes in market interest rates) and unobservable (e.g., changes in unobservable long-dated volatilities) inputs. Changes in Level 3 liabilities measured at fair value for the three months ended March 31, 2016 were as follows (dollars in thousands): Embedded Warrant Conversion Share-settled Debt Total January 1, 2016 3,025 2,073 521 5,619 Issuance of warrants 1,456 - - 1,456 Issuance of convertible notes - 105 - 105 Conversion of 12% senior convertible debentures to common stock - - - - Conversion of share-settled debt to common stock - (35 ) (25 ) (60 ) Change in fair value (2,408 ) (51 ) (20 ) (2,479 ) March 31, 2016 $ 2,073 $ 2,092 $ 476 $ 4,641 The Company’s warrant liabilities, derivative liabilities and share-settled debt are measured at fair value using the Monte Carlo simulation valuation methodology. A summary of weighted average (in aggregate) about significant unobservable inputs (Level 3 inputs) used in measuring the Company’s warrant liabilities that are categorized within Level 3 of the fair value hierarchy for the years ended December 31, 2015 is as follows: As of March 31, 2016 Embedded Warrant Conversion Feature Share-settled Debt Contractual life (years) 4.63 0.50 0.10 Annualized volatility 72 % 72 % 72 % Conversion price $ 0.29 $ 0.06 $ 0.30 Expected dividends 0 % 0 % 0 % Risk-free investment rate 1.1 % 0.4 % 0.4 % * The Company uses comparable companies within the same industry to derive at the 72% annualized volatility.

Temporary Equity

Temporary Equity	3 Months Ended
	Mar. 31, 2016
Temporary Equity [Abstract]
TEMPORARY EQUITY	9. TEMPORARY EQUITY Series E Preferred Stock The following table summarizes the Company’s Series E Preferred Stock activities for the three months ended March 31, 2016 (amount in thousands): Series E convertible Shares Value Balances as of January 1, 2016 - $ - Reclass Series E to temporary equity 9,766 8,764 Proceeds from sale of Series E preferred stock 256 230 Common stock issued in conversion of Series E convertible preferred stock (1,205 ) (1,205 ) Deemed dividends on conversion of Series E convertible preferred stock to common stock - 130 Repurchase of Series E preferred stock (248 ) (248 ) Offering cost related to repurchase of Series E preferred stock - (10 ) Deemed dividends on repurchase of Series E convertible preferred stock - 27 Deemed dividends related to accretion of redemption value - 3,137 Legal fees related to stock financing - (51 ) Balance as of March 31, 2016 8,569 $ 10,774 Securities Purchase Agreement On February 8, 2016, the Company entered into a Securities Purchase Agreement with institutional investors for the sale of 255.56 (including 10% OID) shares of the Company’s 12% Series E Preferred Stock (the “Series E Preferred Stock”) in a registered direct offering, subject to customary closing conditions. The gross proceeds to the Company from the offering were $230,000. Each share of Series E Preferred Stock has a stated value of $1,000 and is convertible into shares of common stock at a conversion price of $7.50 provided if the Holder delivers a conversion notice within 5 trading days following a period that the average of 3 consecutive VWAPs is less than $9.00, the conversion price shall be equal to lesser of the then conversion price and 65% of the lowest 2 consecutive VWAPs out of the prior 10 consecutive trading days prior to the delivery of the conversion notice. Repurchase agreement of Series E Preferred Stock The Company entered into repurchase agreements with one of its institutional investors pursuant to which the Company repurchased an aggregate of 248 shares of Series E Preferred Stock at a price of $385,000, including offering costs of $10,000. Conversion of Series E Preferred Stock During the quarter ended March 31, 2016, 1,205 shares of Series E Preferred were converted to 10.3 million shares of common stock. Upon conversion, the Company recorded an additional deemed dividend of $130,000. Temporary equity The Series E Preferred Stock is being classified as temporary equity because it has redemption features that are outside of the Company’s control upon certain triggering events, such as the failure of the Company to at all times have an effective registration statement or usable prospectus that would allow for the resale the Conversion Shares. Redemption value The Company is carrying the Series E at its maximum redemption amount at March 31, 2016 as the security is not currently redeemable, but is redeemable subsequent to March 31, 2016. The Company recognized the change immediately as if the redemption was to occur as of March 31, 2016. The current redemption amount is $10.8 million as of March 31, 2016. Series H Preferred Stock The following table summarizes the Company’s Series H Preferred Stock activities for the three months ended March 31, 2016 (amount in thousands): Series H convertible Shares Value Balance as of January 1, 2016 2,816 $ 3,154 Series H preferred stock issued for note conversion 110 100 Proceeds from sale of Series H preferred stock, net of issuance cost of $0.5 million 4,883 3,890 Beneficial conversion feature of Series H convertible preferred stock - (610 ) Deemed dividends related to immediate accretion of beneficial conversion feature of Series H convertible preferred stock - 610 Fair Value of common stock warrant issued with Series H convertible preferred stock - (1,456 ) Common stock issued in conversion of Series H convertible preferred stock (1,354 ) (1,354 ) Deemed dividends on conversion of Series H convertible preferred stock to common stock - 923 Repurchase of Series H convertible preferred stock (413 ) (413 ) Offering cost related to repurchase of Series H convertible preferred stock - (10 ) Deemed dividends on repurchase of Series H convertible preferred stock - 48 Deemed dividends related to accretion of redemption value - 5,095 Balance as of March 31, 2016 6,042 $ 9,977 Securities Purchase Agreement During the quarter ended March 31, 2016, the Company entered into multiple Securities Purchase with accredited investors for sale of an aggregate of 4,883 (including 10% OID) shares of 12% Series H Preferred Stock and warrants to purchase 13,920,000 shares of common stock in registered direct offerings. The warrants are immediately exercisable, expire on the five-year anniversary from issuance and have an exercise price of $0.40 per share. The aggregate gross proceeds to the Company were $4.4 million. The Company also incurred $535,000 related offering cost. Each share of Series H Preferred Stock has a stated value of $1,000 and is convertible into shares of common stock $0.06 as of March 31, 2016. During the quarter ended March 31, 2016, the Company recorded a deemed dividend of $610,000 related to the beneficial conversion feature of the Series H Convertible Preferred stock. The Company entered into repurchase agreements with one of its institutional investor pursuant to which the Company repurchased an aggregate 413 shares of Series H Preferred Stock at a price of $635,000, including offering costs of $10,000. Conversion of Series H Preferred Stock During the quarter ended March 31, 2016, 1,354 shares of Series H Preferred were converted to 18.4 million shares of common stock. Upon conversion the Company recorded an additional deemed dividend of $923,000 associated with the make-whole provision Redemption value The Company is carrying the Series H at its maximum redemption amount at March 31, 2016 as the security is currently redeemable. The Company recognized the change immediately as if the redemption was to occur as of March 31, 2016. The current redemption amount is $10.0 million as of March 31, 2016.

Stockholders' Equity

Stockholders' Equity	3 Months Ended
	Mar. 31, 2016
Stockholders' Equity [Abstract]
STOCKHOLDERS' EQUITY	10. STOCKHOLDERS' EQUITY Warrants Common Stock Purchase Warrants The following table summarizes the Company’s warrant activities for the three months ended March 31, 2016: Weighted Average Weighted Remaining Number of Average Contractual Term Outstanding as of December 31, 2015 12,809,950 $ 1.14 4.52 Issued in connection with various financings (1) 14,744,666 0.48 Reset warrants (2) 25,284,713 0.24 Outstanding as of March 31, 2016 52,839,329 $ 0.39 4.63 (1) The warrants contain “down round protection” and the Company classifies these warrant instruments as liabilities at their fair value and adjusts the instruments to fair value at each reporting period. (2) Certain warrants contain aggregate exercise provisions, and upon a reset the exercise price is decreased and the amount of common stock available under the warrant agreement increases. During the 1st quarter a reset occurred decreasing the exercise price from $2.00 to $0.24, and increasing the amount of common stock available to be issued from 12,727,000 to 38,011,000

Stock Option Plans

Stock Option Plans	3 Months Ended
	Mar. 31, 2016
Stock Option Plans [Abstract]
STOCK OPTION PLANS	11. STOCK OPTION PLANS Stock-based compensation expense for all plans is classified in the statements of operations as follows (dollars in thousands): Three Months Ended March 31, 2016 2015 Research and development $ 39 $ 184 General and administrative 122 304 Total $ 161 $ 488 At March 31, 2016, there was a total of approximately $1.9 million of unrecognized compensation cost, related to non-vested stock option awards, which is expected to be recognized over a weighted-average period of approximately 2.1 years.

Related-Party Transitions

Related-Party Transitions	3 Months Ended
	Mar. 31, 2016
Related-Party Transactions [Abstract]
RELATED-PARTY TRANSACTIONS	12. RELATED-PARTY TRANSACTIONS Convertible Notes Receivable See footnote 4 for a discussion of related party convertible notes receivable. Notes Payable The Company has a demand promissory note with Neurotrophics, which is due 365 days upon demand of the holder. At the option of the Company, the note and the accrued interest owed can be repaid by issuing shares of its common stock based on the closing price of the Company’s common stock on the day of the conversion. The conversion price if converted on March 31, 2016 would be $0.05 related to the note and accrued interest on the note and would convert to approximately 5.2 million shares.

Subsequent Events

Subsequent Events	3 Months Ended
	Mar. 31, 2016
Subsequent Events [Abstract]
SUBSEQUENT EVENTS	13. SUBSEQUENT EVENTS Subsequent to April 1, 2016, the Company issued shares of its common stock as follows: ● 3.4 million shares of common stock upon conversion of 80 shares of Series E Preferred Stock in accordance with the original terms; ● 10.3 million shares of common stock upon conversion of 251 of Series H Preferred Stock in accordance with the original terms; ● 0.8 million shares of common stock as payment of dividends on its Series H Preferred Stock; See below for more detail regarding certain debt and equity related transactions. Debt Financing On April 14, 2016, the Company entered into a Securities Purchase Agreement (the “Notes SPA”) with three institutional investors for the sale of an aggregate principal amount $1,500,000 (including 10% OID) 10% Senior Secured Convertible Promissory Notes due April 17, 2017 (the “Senior Secured Notes”) with an annual interest rate of 12% and a warrant to purchase 1,350,000 shares of common stock (the “Warrant”) in a private placement offering (the “Offering”). The gross proceeds to the Company from the Offering were $1,350,000 Pursuant to the terms of the Notes SPA, the investors agreed to purchase additional aggregate principal amount of $1,555,556 (including 10% OID) of Senior Secured Notes with an annual interest rate of 12% and Warrants to purchase 1,400,000 shares of the Company’s common stock on the first trading date after the registration statement which is the subject of the registration rights agreement is filed, and an additional $1,388,889 (including 10% OID) of Senior Secured Notes and Warrants to purchase 1,250,000 shares of the Company’s common stock on the 61st day after such registration statement is declared effective or such earlier date as mutually agreed to among the investors, subject to the satisfaction of customary closing conditions. In connection with the issuance of the Senior Secured Notes and Warrants, the Company entered into a Security Agreement and an Intellectual Property Security Agreement with the investor (the “Security Agreement”) pursuant to which the Company agreed to grant a security interest in all of its assets to the investor in order to secure the prompt payment, performance and discharge in full of all of the Company’s obligations under the Senior Secured Notes. In addition, each of the Company’s wholly owned subsidiaries entered into a Subsidiary Guarantee, pursuant to which each of the subsidiaries, jointly and severally, agreed to guarantee the obligations of the Company under the Senior Secured Notes. Acquisition of Amarantus Diagnostics by Avant Diagnostics, Inc. On May 11, 2016 (the “Effective Date”), Amarantus, Amarantus Diagnostics, Inc., a wholly-owned subsidiary of Amarantus (“AMDX”), and Avant Diagnostics, Inc. (“Avant”) entered into a Share Exchange Agreement (the “Exchange Agreement”). Pursuant to the terms of the Exchange Agreement, Avant purchased 100% of the outstanding capital stock of AMDX from Amarantus (the “AMDX Acquisition”). The AMDX Acquisition closed upon the execution of the Exchange Agreement. Gerald Commissiong, President and Chief Executive Officer of Amarantus, became a member of Avant’s Board of Directors upon closing of the AMDX Acquisition. Avant paid to Amarantus aggregate consideration of 80,000,000 shares of Avant’s common stock for the AMDX Acquisition, subject to the issuance of additional shares upon the occurrence of certain events set forth in the Exchange Agreement (the “AMDX Consideration”). Each share of Avant common stock received in connection with the AMDX Acquisition shall be subject to a lock-up beginning on the Effective Date and ending on the earlier of (i) eighteen (18) months after such date or (ii) a Change in Control (as defined in the Exchange Agreement). In connection with the Exchange Agreement, on the Effective Date, the Avant issued to Amarantus a convertible promissory note in the principal amount of $50,000 (the "Note"). The Note bears interest at 12% per annum and matures one year from the date of issuance. The Note will be convertible at the option of the Amarantus at any time into shares of Avant’s common stock, at an initial conversion price equal to $0.20, subject to adjustment. The conversion price of the Note is subject to customary adjustments provisions for stock splits, stock dividends, recapitalizations and the like. Amarantus has contractually agreed to restrict its ability to convert the Note such that the number of shares of Avant’s common stock held by Amarantus and its affiliates after such conversion does not exceed 4.99% of Avant's then issued and outstanding shares of common stock. Note Receivable from Theranostics Health Acquisition On May 11, 2016, Avant entered into an Asset Purchase Agreement with Theranostics Health, Inc. (“THI”). Pursuant to the terms of the purchase agreement between Avant and THI, the note receivable in the principal amount of $400,000 issued by THI to the Company on March 1, 2016 was assumed by Avant. The note is currently an obligation of Avant and is convertible into shares of common stock of Avant upon its original terms.

General (Policies)

General (Policies)	3 Months Ended
	Mar. 31, 2016
General [Abstract]
Reclassification	Reclassification
Use of Estimates	Use of Estimates
Research and Development Expenditures	Research and Development Expenditures
Related Party, Fair Value Convertible Notes Receivable	Related Party, Fair Value Convertible Notes Receivable
Recent Accounting Pronouncements	Recent Accounting Pronouncements In January 2016, FASB issued ASU 2016-01, Recognition and Measurement of Financial Assets and Financial Liabilities In February 2016, FASB issued ASU No. 2016-02, Leases (Topic 842) Leases (Topic 840) In March 2016, the FASB issued ASU No. 2016-09, Compensation – Stock Compensation (Topic 718): Improvements to Employee Share-Based Payment Accounting

Net Loss Per Share (Tables)

Net Loss Per Share (Tables)	3 Months Ended
	Mar. 31, 2016
Net Loss Per Share [Abstract]
Schedule of computation of the basic and diluted net loss per share	For the three months ended March 31, 2016 2015 Numerator: Net loss $ (1,576 ) $ (6,580 ) Preferred stock dividend (749 ) (828 ) Deemed dividends on convertible preferred stock (10,307 ) - Net loss attributable to common stockholders $ (12,632 ) $ (7,408 ) Denominator: Common stock outstanding 33,720,000 7,232,000 Basic and diluted net loss per share $ (0.37 ) $ (1.02 ) Potentially dilutive securities consist of: For the three months ended March 31, 2016 2015 Outstanding common stock options 308,000 379,000 Outstanding preferred stock option 829,000 829,000 Common stock purchase warrants 52,839,000 306,000 Related party liability and accrued interest 5,159,000 34,000 Notes payable 10,060,000 - Convertible senior secured promissory notes and accrued interest 94,803,000 - Share-settled debt and accrued interest 6,936,000 - Convertible preferred stock Series C 5,000 5,000 Convertible preferred stock Series E 95,204,000 - Convertible preferred stock Series H 100,696,000 - Potentially dilutive securities 366,839,000 1,553,000

Related Party Convertible Not22

Related Party Convertible Notes Receivable, At Fair Value (Tables)	3 Months Ended
	Mar. 31, 2016
Related Party Convertible Notes Receivable, At Fair Value [Abstract]
Summary of outstanding related party convertible notes receivable	Stated Conversion Carrying Issue Date Maturity Date Interest Rate Terms Value Avant Diagnostics, Inc 3/7/2016 3/7/2017 12 % $ 0.20 $ 100,000 Theranostics Health, Inc 2/29/2016 2/28/2017 8 % $ 40.64 400,000 Ending balance as of March 31, 2016 $ 500,000

Senior Secured Convertible Pr23

Senior Secured Convertible Promissory Notes (Tables)	3 Months Ended
	Mar. 31, 2016
Notes Payable / Senior Secured Convertible Promissory Notes [Abstract]
Summary of outstanding senior secured convertible notes	Stated Accumulated Issue Maturity Interest Rate Conversion Face Value Debt Carrying Delafeild Investments Ltd 9/30/2015 9/29/2016 12 % $ 0.06 $ 3,056 $ (1,716 ) $ 1,340 Dominion Capital LLC 9/30/2015 9/29/2016 12 % $ 0.06 2,096 (1,177 ) 919 GEMG LLC 3/9/2016 7/1/2016 12 % $ 0.06 200 (70 ) 130 Ending balance as of March 31, 2016 $ 5,352 $ (2,963 ) $ 2,389

Fair Value Measurements (Tables

Fair Value Measurements (Tables)	3 Months Ended
	Mar. 31, 2016
Fair Value Measurements [Abstract]
Schedule of financial assets and liabilities that are measured at fair value on a recurring basis	Fair value measured at March 31, 2016 Fair value Quoted Significant Significant 2016 (Level 1) (Level 2) (Level 3) Assets: Related party convertible notes receivable $ 500 $ - $ - $ 500 Total fair value $ 500 $ - $ - $ 500 Liabilities: Embedded conversion feature $ 2,092 $ - $ - $ 2,092 Warrant liability 2,073 - - 2,073 Share-settled debt 476 - - 476 Total fair value $ 4,641 $ - $ - $ 4,641
Summary of changes in the fair value of the company's Level 3 financial liabilities	Embedded Warrant Conversion Share-settled Debt Total January 1, 2016 3,025 2,073 521 5,619 Issuance of warrants 1,456 - - 1,456 Issuance of convertible notes - 105 - 105 Conversion of 12% senior convertible debentures to common stock - - - - Conversion of share-settled debt to common stock - (35 ) (25 ) (60 ) Change in fair value (2,408 ) (51 ) (20 ) (2,479 ) March 31, 2016 $ 2,073 $ 2,092 $ 476 $ 4,641
Schedule of fair value of the warrants determined using the Black-Scholes model with the following assumptions	As of March 31, 2016 Embedded Warrant Conversion Feature Share-settled Debt Contractual life (years) 4.63 0.50 0.10 Annualized volatility 72 % 72 % 72 % Conversion price $ 0.29 $ 0.06 $ 0.30 Expected dividends 0 % 0 % 0 % Risk-free investment rate 1.1 % 0.4 % 0.4 % * The Company uses comparable companies within the same industry to derive at the 72% annualized volatility.

Temporary Equity (Table)

Temporary Equity (Table)	3 Months Ended
	Mar. 31, 2016
Series E Preferred Stock [Member]
Temporary Equity [Line Items]
Schedule of temporary equity	Series E convertible Shares Value Balances as of January 1, 2016 - $ - Reclass Series E to temporary equity 9,766 8,764 Proceeds from sale of Series E preferred stock 256 230 Common stock issued in conversion of Series E convertible preferred stock (1,205 ) (1,205 ) Deemed dividends on conversion of Series E convertible preferred stock to common stock - 130 Repurchase of Series E preferred stock (248 ) (248 ) Offering cost related to repurchase of Series E preferred stock - (10 ) Deemed dividends on repurchase of Series E convertible preferred stock - 27 Deemed dividends related to accretion of redemption value - 3,137 Legal fees related to stock financing - (51 ) Balance as of March 31, 2016 8,569 $ 10,774
Series H Preferred Stock [Member]
Temporary Equity [Line Items]
Schedule of temporary equity	Series H convertible Shares Value Balance as of January 1, 2016 2,816 $ 3,154 Series H preferred stock issued for note conversion 110 100 Proceeds from sale of Series H preferred stock, net of issuance cost of $0.5 million 4,883 3,890 Beneficial conversion feature of Series H convertible preferred stock - (610 ) Deemed dividends related to immediate accretion of beneficial conversion feature of Series H convertible preferred stock - 610 Fair Value of common stock warrant issued with Series H convertible preferred stock - (1,456 ) Common stock issued in conversion of Series H convertible preferred stock (1,354 ) (1,354 ) Deemed dividends on conversion of Series H convertible preferred stock to common stock - 923 Repurchase of Series H convertible preferred stock (413 ) (413 ) Offering cost related to repurchase of Series H convertible preferred stock - (10 ) Deemed dividends on repurchase of Series H convertible preferred stock - 48 Deemed dividends related to accretion of redemption value - 5,095 Balance as of March 31, 2016 6,042 $ 9,977

Stockholders' Equity (Tables)

Stockholders' Equity (Tables)	3 Months Ended
	Mar. 31, 2016
Stockholders' Equity [Abstract]
Schedule of warrant activities	Weighted Average Weighted Remaining Number of Average Contractual Term Outstanding as of December 31, 2015 12,809,950 $ 1.14 4.52 Issued in connection with various financings (1) 14,744,666 0.48 Reset warrants (2) 25,284,713 0.24 Outstanding as of March 31, 2016 52,839,329 $ 0.39 4.63 (1) The warrants contain “down round protection” and the Company classifies these warrant instruments as liabilities at their fair value and adjusts the instruments to fair value at each reporting period. (2) Certain warrants contain aggregate exercise provisions, and upon a reset the exercise price is decreased and the amount of common stock available under the warrant agreement increases. During the 1st quarter a reset occurred decreasing the exercise price from $2.00 to $0.24, and increasing the amount of common stock available to be issued from 12,727,000 to 38,011,000

Stock Option Plans (Tables)

Stock Option Plans (Tables)	3 Months Ended
	Mar. 31, 2016
Stock Option Plans [Abstract]
Schedule of stock-based compensation	Three Months Ended March 31, 2016 2015 Research and development $ 39 $ 184 General and administrative 122 304 Total $ 161 $ 488

General (Details)

General (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2016	Mar. 31, 2015
General Texual [Abstract]
Research and development costs	$ 1,357	$ 2,477

Net Loss Per Share (Details)

Net Loss Per Share (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended
	Mar. 31, 2016	Mar. 31, 2015
Numerator:
Net loss	$ (1,576)	$ (6,580)
Preferred stock dividend	749	$ 828
Deemed dividends on convertible preferred stock	(10,307)
Net loss attributable to common stockholders	$ (12,632)	$ (7,408)
Denominator:
Common stock outstanding	33,720,000	7,232,000
Basic and diluted net loss per share	$ (0.37)	$ (1.02)
Potentially dilutive securities consist of:
Outstanding common stock options	308,000	379,000
Outstanding preferred stock option	829,000	829,000
Common stock purchase warrants	52,839,000	306,000
Related party liability and accrued interest	5,159,000	34,000
Notes payable	10,060,000
Convertible senior secured promissory notes and accrued interest	94,803,000
Share-settled debt and accrued interest	6,936,000
Potentially dilutive securities	366,839,000	1,553,000
Series C Preferred Stock [Member]
Potentially dilutive securities consist of:
Convertible preferred stock	5,000	5,000
Series E Preferred Stock [Member]
Potentially dilutive securities consist of:
Convertible preferred stock	95,204,000
Series H Preferred Stock [Member]
Potentially dilutive securities consist of:
Convertible preferred stock	100,696,000

Related Party Convertible Not30

Related Party Convertible Notes Receivable, At Fair Value (Details) $ / shares in Units, $ in Thousands	3 Months Ended
	Mar. 31, 2016USD ($)$ / shares
Related Party Transaction [Line Items]
Stated Interest Rate	12.00%
Conversion Term | $ / shares	$ 0.05
Carrying Value | $	$ 500,000
Avant Diagnostics Inc [Member]
Related Party Transaction [Line Items]
Issuance Date	Mar. 7, 2016
Maturity Date	Mar. 7, 2017
Stated Interest Rate	12.00%
Conversion Term | $ / shares	$ 0.20
Carrying Value | $	$ 100,000
Theranostic Health Inc [Member]
Related Party Transaction [Line Items]
Issuance Date	Feb. 29, 2016
Maturity Date	Feb. 28, 2017
Stated Interest Rate	8.00%
Conversion Term | $ / shares	$ 40.64
Carrying Value | $	$ 400,000

Related Party Convertible Not31

Related Party Convertible Notes Receivable, At Fair Value (Details Textual) $ / shares in Units, $ in Thousands, shares in Millions	3 Months Ended
	Mar. 31, 2016USD ($)$ / sharesshares
Related Party Transaction [Line Items]
Convertible note, carring value | $	$ 500,000
Interest rate	12.00%
Conversion of common stock | shares	5.2
Conversion price | $ / shares	$ 0.05
Theranostic Health Inc [Member]
Related Party Transaction [Line Items]
Convertible note, carring value | $	$ 400,000
Maturity date	Feb. 28, 2017
Interest rate	8.00%
Conversion of common stock | shares	80
Conversion price | $ / shares	$ 40.64
Conversion price, description	The conversion price of the Note is subject to weighted average anti-dilution price protection if the dilutive issuances are for less than $1 million and full ratchet anti-dilution protection if the dilutive issuances are for more than $1 million.
Avant Diagnostics Inc [Member]
Related Party Transaction [Line Items]
Convertible note, carring value | $	$ 100,000
Maturity date	Mar. 7, 2017
Interest rate	12.00%
Conversion price | $ / shares	$ 0.20

Notes Payable (Details)

Notes Payable (Details) - USD ($)	Mar. 31, 2016	Mar. 09, 2016
Short-term Debt [Line Items]
Interest Rate	12.00%
Notes payable aggregate amount, outstanding	$ 600,000
Notes Payable	100,000
Accured interest	$ 30,000
Two Investor (Member)
Short-term Debt [Line Items]
Interest Rate		12.00%
Senior secured convertible note, Principal amounts		$ 200,000
Third Investor [Member]
Short-term Debt [Line Items]
Interest Rate		12.00%
Senior secured convertible note, Principal amounts		$ 100,000

Senior Secured Convertible Pr33

Senior Secured Convertible Promissory Notes (Details) $ / shares in Units, $ in Thousands	3 Months Ended
	Mar. 31, 2016USD ($)$ / shares
Debt Instrument [Line Items]
Stated Interest Rate	12.00%
Conversion Terms | $ / shares	$ 0.05
Accumulated Debt Discount	$ (2,963)
Carrying Value	$ 2,389
Delafeild Investments Ltd [Member] | Senior Secured Convertible Promissory Notes [Member]
Debt Instrument [Line Items]
Issue Date	Sep. 30, 2015
Maturity Date	Sep. 29, 2016
Stated Interest Rate	12.00%
Conversion Terms | $ / shares	$ 0.06
Face Value	$ 3,056
Accumulated Debt Discount	(1,716)
Carrying Value	$ 1,340
Dominion Capital LLC [Member] | Senior Secured Convertible Promissory Notes [Member]
Debt Instrument [Line Items]
Issue Date	Sep. 30, 2015
Maturity Date	Sep. 29, 2016
Stated Interest Rate	12.00%
Conversion Terms | $ / shares	$ 0.06
Face Value	$ 2,096
Accumulated Debt Discount	(1,177)
Carrying Value	$ 919
GEMG LLC [Member] | Senior Secured Convertible Promissory Notes [Member]
Debt Instrument [Line Items]
Issue Date	Mar. 9, 2016
Maturity Date	Jul. 1, 2016
Stated Interest Rate	12.00%
Conversion Terms | $ / shares	$ 0.06
Face Value	$ 200
Accumulated Debt Discount	(70)
Carrying Value	$ 130

Senior Secured Convertible Pr34

Senior Secured Convertible Promissory Notes (Details Textual) - USD ($)	Mar. 09, 2016	Mar. 31, 2016	Mar. 31, 2015	Dec. 31, 2015
Debt Instrument [Line Items]
Accumulated Debt Discount		$ (2,963,000)
Conversion shares of common stock		5,200,000
Senior secured convertible notes payable		$ 2,389,000		$ 1,316,000
Interest Rate		12.00%
Conversion of common stock		$ 100,000
Loss on the conversion of debt on fair value		$ (74,000)
Series H Preferred Stock [Member]
Debt Instrument [Line Items]
Conversion shares of common stock		110
Embedded conversion feature		$ 610,000
Conversion of common stock		$ 100,000
Percentage of OID		10.00%
Other Convertible Notes [Member]
Debt Instrument [Line Items]
Accumulated Debt Discount		$ 35,000
Conversion shares of common stock		2,000,000
Senior secured convertible notes payable	$ 300,000
Interest Rate	12.00%
Embedded conversion feature	$ 105,000
Conversion of common stock		$ 100,000
Loss on the conversion of debt on fair value	$ 40,000
Dominion Capital LLC [Member] | Senior Secured Convertible Promissory Notes [Member]
Debt Instrument [Line Items]
Accumulated Debt Discount		$ (1,177,000)
Conversion shares of common stock		1,300,000
Accrued interest		$ 75,000
Interest Rate		12.00%

Share-Settled Debt (Details)

Share-Settled Debt (Details)	3 Months Ended
	Mar. 31, 2016USD ($)$ / sharesshares
Share-Settled Debt (Textual)
Debt conversion converted value settled debt	$ 25,000
Debt conversion converted share settled debt of common stock | shares	495,188
Debt conversion converted share settled debt of common stock per share | $ / shares	$ 0.12
Loss on settled debt conversion amount	$ 34,000

Fair Value Measurements (Detail

Fair Value Measurements (Details) - USD ($) $ in Thousands	Mar. 31, 2016	Dec. 31, 2015
Liabilities:
Share-settled debt	$ 476	$ 521
Fair Value, Measurements, Recurring [Member]
Assets:
Related party convertible notes receivable	500
Total fair value	500
Liabilities:
Embedded conversion feature	2,092
Warrant Liability	2,073
Share-settled debt	476
Total fair value	$ 4,641
Fair Value Measurements Level 1 [Member] | Fair Value, Measurements, Recurring [Member]
Assets:
Related party convertible notes receivable
Total fair value
Liabilities:
Embedded conversion feature
Warrant Liability
Share-settled debt
Total fair value
Fair Value Measurements Level 2 [Member] | Fair Value, Measurements, Recurring [Member]
Assets:
Related party convertible notes receivable
Total fair value
Liabilities:
Embedded conversion feature
Warrant Liability
Share-settled debt
Total fair value
Fair Value Measurements Level 3 [Member] | Fair Value, Measurements, Recurring [Member]
Assets:
Related party convertible notes receivable	$ 500
Total fair value	500
Liabilities:
Embedded conversion feature	2,092
Warrant Liability	2,073
Share-settled debt	476
Total fair value	$ 4,641

Fair Value Measurements (Deta37

Fair Value Measurements (Details 1) $ in Thousands	3 Months Ended
	Mar. 31, 2016USD ($)
Embedded Conversion Feature [Member]
Summary of changes in the fair value of the Level 3 financial liabilities
January 1, 2016	$ 5,619
Issuance of warrants	1,456
Issuance of convertible notes	$ 105
Conversion of 12% senior convertible debentures to common stock
Conversion of share-settled debt to common stock	$ (60)
Change in fair value	(2,479)
March 31, 2016	$ 4,641
Fair Value, Inputs, Level 3 [Member]
Summary of changes in the fair value of the Level 3 financial liabilities
January 1, 2016
March 31, 2016	$ 8,365
Fair Value, Inputs, Level 3 [Member] | Share-settled Debt [Member]
Summary of changes in the fair value of the Level 3 financial liabilities
January 1, 2016	$ 521
Issuance of warrants
Issuance of convertible notes
Conversion of 12% senior convertible debentures to common stock
Conversion of share-settled debt to common stock	$ (25)
Change in fair value	(20)
March 31, 2016	476
Fair Value, Inputs, Level 3 [Member] | Embedded Conversion Feature [Member]
Summary of changes in the fair value of the Level 3 financial liabilities
January 1, 2016	$ 2,073
Issuance of warrants
Issuance of convertible notes	$ 105
Conversion of 12% senior convertible debentures to common stock
Conversion of share-settled debt to common stock	$ (35)
Change in fair value	(51)
March 31, 2016	2,092
Fair Value, Inputs, Level 3 [Member] | Warrant Liability [Member]
Summary of changes in the fair value of the Level 3 financial liabilities
January 1, 2016	3,025
Issuance of warrants	$ 1,456
Issuance of convertible notes
Conversion of 12% senior convertible debentures to common stock
Conversion of share-settled debt to common stock
Change in fair value	$ (2,408)
March 31, 2016	$ 2,073

Fair Value Measurements (Deta38

Fair Value Measurements (Details 2)	3 Months Ended
	Mar. 31, 2016$ / shares
Summary of fair value of the warrants
Annualized volatility	72.00%
Share-settled Debt [Member]
Summary of fair value of the warrants
Contractual life (years)	1 month 6 days
Annualized volatility	72.00%	[1]
Conversion price	$ 0.30
Expected dividends	0.00%
Risk-free investment rate	0.40%
Warrant Liability [Member]
Summary of fair value of the warrants
Contractual life (years)	4 years 7 months 17 days
Annualized volatility	72.00%	[1]
Conversion price	$ 0.29
Expected dividends	0.00%
Risk-free investment rate	1.10%
Embedded Conversion Feature [Member]
Summary of fair value of the warrants
Contractual life (years)	6 months
Annualized volatility	72.00%	[1]
Conversion price	$ 0.06
Expected dividends	0.00%
Risk-free investment rate	0.40%
[1]	The Company uses comparable companies within the same industry to derive at the 72% annualized volatility.

Fair Value Measurements (Deta39

Fair Value Measurements (Details Textual)	3 Months Ended
	Mar. 31, 2016
Fair Value Measurements [Abstract]
Debt conversion, converted instrument, Rate	12.00%
Annualized volatility	72.00%

Temporary Equity (Details)

Temporary Equity (Details) $ in Thousands	3 Months Ended
	Mar. 31, 2016USD ($)shares
Temporary Equity [Line Items]
Preferred stock issued for note conversion	$ 500,000
Series E Preferred Stock [Member]
Temporary Equity [Line Items]
Begining Balance | shares
Begining Balance, Par value
Reclass to temporary equity, Shares | shares	9,766
Reclass to temporary equity, Par value	$ 8,764
Proceeds from sale of preferred stock, Shares | shares	256
Proceeds from sale of preferred stock, Par value	$ 230
Common stock issued in conversion of convertible preferred stock, Shares | shares	(1,205)
Common stock issued in conversion of convertible preferred stock, Par value	$ (1,205)
Deemed dividends on conversion of convertible preferred stock to common stock, Par value	$ 130
Repurchase of convertible preferred stock, Shares | shares	(248)
Repurchase of convertible preferred stock, Par value	$ (248)
Offering cost related to repurchase of preferred stock, Par value	(10)
Deemed dividends on repurchase of convertible preferred stock, Par value	27
Deemed dividends related to accretion of redemption value, Par value	3,137
Legal fees related to stock financing, Par value	$ (51)
Ending Balance | shares	8,569
Ending Balance, Par value	$ 10,774
Series H Preferred Stock [Member]
Temporary Equity [Line Items]
Begining Balance | shares	2,816
Begining Balance, Par value	$ 3,154
Preferred stock issued for note conversion, Shares | shares	110
Preferred stock issued for note conversion	$ 100
Proceeds from sale of preferred stock, Shares | shares	4,883
Proceeds from sale of preferred stock, Par value	$ 3,890
Beneficial conversion feature of convertible preferred stock, Par value	(610)
Deemed dividends related to immediate accretion of beneficial conversion feature of convertible preferred stock, Par value	610
Fair Value of common stock warrant issued with convertible preferred stock, Par value	$ (1,456)
Common stock issued in conversion of convertible preferred stock, Shares | shares	(1,354)
Common stock issued in conversion of convertible preferred stock, Par value	$ (1,354)
Deemed dividends on conversion of convertible preferred stock to common stock, Par value	$ 923
Repurchase of convertible preferred stock, Shares | shares	(413)
Repurchase of convertible preferred stock, Par value	$ (413)
Offering cost related to repurchase of preferred stock, Par value	(10)
Deemed dividends on repurchase of convertible preferred stock, Par value	48
Deemed dividends related to accretion of redemption value, Par value	$ 5,095
Ending Balance | shares	6,042
Ending Balance, Par value	$ 9,977

Temporary Equity (Details Textu

Temporary Equity (Details Textual) - USD ($)	Feb. 08, 2016	Mar. 31, 2016
Temporary Equity [Line Items]
Interest Rate		12.00%
Conversion of common stock		$ 100,000
Conversion price		$ 0.05
Series E Preferred Stock [Member]
Temporary Equity [Line Items]
Repurchase of convertible preferred stock		$ (248,000)
Repurchase of convertible preferred stock, shares		(248)
Common stock issued in conversion of convertible preferred stock, Shares		1,205
Deemed dividends on conversion of convertible preferred stock to common stock		$ 130,000
Redemption value		10,800,000
Series E Preferred Stock [Member] | Securities Purchase Agreement [Member]
Temporary Equity [Line Items]
Issuance of common stock to accredited investor and institutional investors	255.56
Percentage of OID	10.00%
Interest Rate	12.00%
Gross proceeds from Offering	$ 230,000
Conversion of common stock	$ 1,000
Conversion price	$ 7.50
Conversion of stock, Description	Each share of Series E Preferred Stock has a stated value of $1,000 and is convertible into shares of common stock at a conversion price of $7.50 provided if the Holder delivers a conversion notice within 5 trading days following a period that the average of 3 consecutive VWAPs is less than $9.00, the conversion price shall be equal to lesser of the then conversion price and 65% of the lowest 2 consecutive VWAPs out of the prior 10 consecutive trading days prior to the delivery of the conversion notice.
Series E Preferred Stock [Member] | Repurchase Agreement [Member]
Temporary Equity [Line Items]
Offering cost		10,000
Repurchase of convertible preferred stock		$ 385,000
Repurchase of convertible preferred stock, shares		248
Series E Preferred Stock [Member] | Conversion [Member]
Temporary Equity [Line Items]
Common stock issued in conversion of convertible preferred stock, Shares		10,300,000
Series H Preferred Stock [Member]
Temporary Equity [Line Items]
Percentage of OID		10.00%
Offering cost		$ 500,000
Conversion of common stock		100,000
Repurchase of convertible preferred stock		$ (413,000)
Repurchase of convertible preferred stock, shares		(413)
Common stock issued in conversion of convertible preferred stock, Shares		1,354
Deemed dividends on conversion of convertible preferred stock to common stock		$ 923,000
Beneficial conversion feature of convertible preferred stock		610,000
Redemption value		$ 10,000,000
Series H Preferred Stock [Member] | Securities Purchase Agreement [Member]
Temporary Equity [Line Items]
Issuance of common stock to accredited investor and institutional investors		4,883
Percentage of OID		10.00%
Interest Rate		12.00%
Warrant to purchase of common stock		13,920,000
Gross proceeds from Offering		$ 4,400,000
Offering cost		535,000
Conversion of common stock		$ 1,000
Conversion price		$ 0.06
Exercise price of warrant		$ 0.40
Warrant, Description		Warrants are immediately exercisable, expire on the five-year anniversary from issuance and are have an exercise price of $0.40 per share.
Series H Preferred Stock [Member] | Repurchase Agreement [Member]
Temporary Equity [Line Items]
Offering cost		$ 10,000
Repurchase of convertible preferred stock		$ 635,000
Repurchase of convertible preferred stock, shares		413
Series H Preferred Stock [Member] | Conversion [Member]
Temporary Equity [Line Items]
Common stock issued in conversion of convertible preferred stock, Shares		18,400,000

Stockholders' Equity (Details)

Stockholders' Equity (Details) - Warrant [Member] - $ / shares		3 Months Ended	12 Months Ended
		Mar. 31, 2016	Dec. 31, 2015
Schedule of warrant activities
Number of Warrants Outstanding, Beginning balance		12,809,950
Number of Warrants, Issued in connection with various financings	[1]	14,744,666
Number of Warrants, Reset Warrants	[2]	25,284,713
Number of Warrants Outstanding, Ending balance		52,839,329	12,809,950
Weighted Average Exercise Price Outstanding, Beginning Balance		$ 1.14
Weighted Average Exercise Price, Issued in connection with various financings	[1]	0.48
Weighted Average Exercise Price, Reset Warrants	[2]	0.24
Weighted Average Exercise Price Outstanding, Ending Balance		$ 0.39	$ 1.14
Weighted Average Remaining Contractual Term, Outstanding		4 years 7 months 17 days	4 years 6 months 7 days
[1]	The warrants contain "down round protection" and the Company classifies these warrant instruments as liabilities at their fair value and adjusts the instruments to fair value at each reporting period.
[2]	Certain warrants contain aggregate exercise provisions, and upon a reset the exercise price is decreased and the amount of common stock available under the warrant agreement increases. During the 1st quarter a reset occurred decreasing the exercise price from $2.00 to $0.24, and increasing the amount of common stock available to be issued from 12,727,000 to 38,011,000

Stockholders' Equity (Details T

Stockholders' Equity (Details Textual) - Warrant [Member]	3 Months Ended
	Mar. 31, 2016$ / sharesshares
Minimum [Member]
Stockholders' Equity (Textual)
Increasing amount of common stock to be issued | shares	12,727,000
Exercise price of warrant | $ / shares	$ 0.24
Maximum [Member]
Stockholders' Equity (Textual)
Increasing amount of common stock to be issued | shares	38,011,000
Exercise price of warrant | $ / shares	$ 2

Stock Option Plans (Details)

Stock Option Plans (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2016	Mar. 31, 2015
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Stock-based compensation expense	$ 161	$ 488
Research and development [Member]
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Stock-based compensation expense	39	184
General and administrative [Member]
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]
Stock-based compensation expense	$ 122	$ 304

Stock Option Plans (Details Tex

Stock Option Plans (Details Textual) $ in Millions	3 Months Ended
	Mar. 31, 2016USD ($)
Stock Option Plans [Abstract]
Unrecognized compensation cost related to non-vested stock option	$ 1.9
Expected weighted-average period	2 years 1 month 6 days

Related-Party Transitions (Deta

Related-Party Transitions (Details) shares in Millions	3 Months Ended
	Mar. 31, 2016$ / sharesshares
Related-Party Transactions [Abstract]
Term of debt	365 days
Conversion price | $ / shares	$ 0.05
Conversion shares of common stock | shares	5.2

Subsequent Events (Details)

Subsequent Events (Details) - USD ($)	May. 11, 2016	Apr. 14, 2016	Feb. 08, 2016	Apr. 30, 2016	May. 25, 2016	Mar. 31, 2016
Subsequent Event [Line Items]
Percentage senior secured convertible notes						10.00%
Interest Rate						12.00%
Conversion price						$ 0.05
Conversion of common stock						5,200,000
Series E Preferred Stock [Member]
Subsequent Event [Line Items]
Conversion of senior convertible promissory note						$ (1,205,000)
Series H Preferred Stock [Member]
Subsequent Event [Line Items]
Percentage of OID						10.00%
Conversion of senior convertible promissory note						$ (1,354,000)
Conversion of common stock						110
Securities Purchase Agreement [Member] | Series E Preferred Stock [Member]
Subsequent Event [Line Items]
Percentage of OID			10.00%
Interest Rate			12.00%
Gross proceeds from Offering			$ 230,000
Conversion price			$ 7.50
Securities Purchase Agreement [Member] | Series H Preferred Stock [Member]
Subsequent Event [Line Items]
Percentage of OID						10.00%
Interest Rate						12.00%
Gross proceeds from Offering						$ 4,400,000
Conversion price						$ 0.06
Subsequent Event [Member] | Series E Preferred Stock [Member]
Subsequent Event [Line Items]
Conversion of common stock					80
Subsequent Event [Member] | Series E Preferred Stock [Member] | Common Stock [Member]
Subsequent Event [Line Items]
Conversion of common stock					3,400,000
Subsequent Event [Member] | Series H Preferred Stock [Member]
Subsequent Event [Line Items]
Conversion of common stock					251
Subsequent Event [Member] | Series H Preferred Stock [Member] | Common Stock [Member]
Subsequent Event [Line Items]
Conversion of common stock					10,300,000
Preferred stock dividends, shares					800,000
Subsequent Event [Member] | Amarantus Diagnostics Inc [Member]
Subsequent Event [Line Items]
Interest Rate	12.00%
Percentage of outstanding capital stock	100.00%
Conversion of senior convertible promissory note	$ 50,000
Conversion price	$ 0.20
Percentage of conversion of issued and outstanding shares	4.99%
Business acquisition, shares issued	80,000,000
Subsequent Event [Member] | Securities Purchase Agreement [Member]
Subsequent Event [Line Items]
Principal amount		$ 1,500,000		$ 1,555,556
Percentage of OID		10.00%		10.00%
Percentage senior secured convertible notes		10.00%
Interest Rate		12.00%		12.00%
Maturity Date		Apr. 17, 2017
Purchase of Warrants	1,250,000	1,350,000		1,400,000
Gross proceeds from Offering		$ 1,350,000
Additional Secured Notes				$ 1,388,889