Iovance Biotherapeutics (IOVA) 10-K 11 Mar 16 2015 FY Annual report Financial data

Document And Entity Information

Document And Entity Information - USD ($)	12 Months Ended
	Dec. 31, 2015	Feb. 29, 2016	Jun. 30, 2015
Document Information [Line Items]
Document Type	10-K
Amendment Flag	false
Document Period End Date	Dec. 31, 2015
Document Fiscal Year Focus	2,015
Document Fiscal Period Focus	FY
Entity Registrant Name	Lion Biotechnologies, Inc.
Entity Central Index Key	1,425,205
Current Fiscal Year End Date	--12-31
Entity Well-known Seasoned Issuer	No
Entity Voluntary Filers	No
Entity Current Reporting Status	Yes
Entity Filer Category	Accelerated Filer
Entity Public Float			$ 314,385,000
Trading Symbol	LBIO
Entity Common Stock, Shares Outstanding		48,567,720

Balance Sheets

Balance Sheets - USD ($) $ in Thousands	Dec. 31, 2015	Dec. 31, 2014
Current Assets
Cash and cash equivalents	$ 13,642	$ 44,909
Money market funds	19,945	0
Short-term investments available for sale	70,113	0
Prepaid expenses and other current assets	277	66
Total Current Assets	103,977	44,975
Property and equipment, net of accumulated depreciation of $1,103 and $104, respectively	1,676	1,532
Total Assets	105,653	46,507
Current Liabilities
Accounts payable	958	1,248
Accrued expenses	586	328
Accrued payable to officers and former directors	86	86
Total Current Liabilities	$ 1,630	$ 1,662
Commitments and contingencies
Stockholders' Equity
Preferred stock, $0.001 par value; 50,000,000 shares authorized, 1,694 and 5,694 shares issued and outstanding, respectively	$ 0	$ 0
Common stock, $0.000041666 par value; 150,000,000 shares authorized, 48,547,720 and 33,750,188 shares issued and outstanding, respectively	2	2
Common stock to be issued, 303,125 shares	245	245
Accumulated other comprehensive income	48	0
Additional paid-in capital	207,950	121,160
Accumulated deficit	(104,222)	(76,562)
Total Stockholders’ Equity	104,023	44,845
Total Liabilities and Stockholders’ Equity	$ 105,653	$ 46,507

Balance Sheets (Parenthetical)

Balance Sheets (Parenthetical) - USD ($) $ in Thousands	Dec. 31, 2015	Dec. 31, 2014
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment	$ 1,103	$ 104
Preferred Stock, Par or Stated Value Per Share	$ 0.001	$ 0.001
Preferred Stock, Shares Authorized	50,000,000	50,000,000
Preferred Stock, Shares Issued	1,694	5,694
Preferred Stock, Shares Outstanding	1,694	5,694
Common Stock, Par or Stated Value Per Share	$ 0.000041666	$ 0.000041666
Common Stock, Shares Authorized	150,000,000	150,000,000
Common Stock, Shares, Issued	48,547,720	33,750,188
Common Stock, Shares, Outstanding	48,547,720	33,750,188
Common Stock To Be Issued Shares	303,125	303,125

Statements of Operations

Statements of Operations - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Revenues	$ 0	$ 0	$ 0
Costs and expenses
Research and development (including $2,248, $1,144 and $825 in share-based compensation costs)	15,470	3,849	2,154
General and administrative (including $6,275, $2,670 and $1,925 in share-based compensation costs)	12,390	8,192	3,831
Cost of Lion transaction	0	0	16,656
Total costs and expenses	27,860	12,041	22,641
Loss from operations	(27,860)	(12,041)	(22,641)
Other income (expense)
Interest income (expense)	200	6	(445)
Cost to induce exchange transaction	0	0	(2,296)
Total other income (expense)	200	6	(2,741)
Net Loss	(27,660)	(12,035)	(25,382)
Deemed dividend related to beneficial conversion feature of convertible preferred stock	0	0	(8,462)
Net Loss Attributable to common Stockholders	$ (27,660)	$ (12,035)	$ (33,844)
Net Loss Per Share Attributable to common Stockholders, Basic and Diluted	$ (0.62)	$ (0.48)	$ (3.47)
Weighted-Average Common Shares Outstanding, Basic and Diluted	44,410,036	24,985,542	9,762,513

Statements of Operations (Paren

Statements of Operations (Parenthetical) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Research and Development Expense [Member]
Share Based Compensation	$ 2,248	$ 1,144	$ 825
General and Administrative Expense [Member]
Share Based Compensation	$ 6,275	$ 2,670	$ 1,925

Condensed Statements of Compreh

Condensed Statements of Comprehensive Loss - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Net Loss	$ (27,660)	$ (12,035)	$ (25,382)
Other comprehensive income:
Unrealized gain on short-term investments	48	0	0
Comprehensive Loss	$ (27,612)	$ (12,035)	$ (25,382)

Statements of Stockholders' Equ

Statements of Stockholders' Equity - USD ($) $ in Thousands	Total	Preferred Stock [Member]	Common Stock [Member]	Common Stock to be Issued [Member]	Additional Paid-in Capital [Member]	Comprehensive Income [Member]	Accumulated Deficit [Member]
Beginning Balance at Dec. 31, 2012	$ (11,319)	$ 0	$ 0	$ 245	$ 19,119	$ 0	$ (30,683)
Beginning Balance (in Shares) at Dec. 31, 2012		0	818,806
Common stock issued in settlement of notes payable and accrued interest and penalty	9,268		$ 1		9,267
Common stock issued in settlement of notes payable and accrued interest and penalty (in shares)			9,267,641
Common stock issued for cash under the restructuring, net of offering costs of $109	1,239				1,239
Common stock issued for cash under the restructuring, net of offering costs of $109 ( in shares)			1,350,000
Common stock issued to induce exchange transaction	2,296				2,296
Common stock issued to induce exchange transaction (in shares)			2,295,868
Fair value of vested stock options and warrants	747				747
Common stock Issued for Lion transactions	16,656				16,656
Common stock Issued for Lion transactions (in shares)			2,690,000
Common stock issued for services	274				274
Common stock issued for services (in shares)			50,000
Common stock issued to directors	2,003				2,003
Common stock issued to directors (in shares)			400,596
Common stock sold in private placement	5,887				5,887
Common stock sold in private placement (in shares)			3,145,300
Preferred stock sold in private placement	15,909				15,909
Preferred stock sold in private placement (in shares)		17,000
Common stock issued for settlement of payable	25				25
Common stock issued for settlement of payable (in shares)			5,747
Deemed dividend on beneficial conversion feature of preferred stock	0				8,462		(8,462)
Unrealized gain on short-term investments	0
Net Loss	(25,382)						(25,382)
Ending Balance at Dec. 31, 2013	17,603	$ 0	$ 1	245	81,884	0	(64,527)
Ending Balance (in Shares) at Dec. 31, 2013		17,000	20,023,958
Common stock issued to induce exchange transaction	0
Fair value of vested stock options and warrants	2,559				2,559
Common stock issued upon exercise of warrants	3,222				3,222
Common stock issued upon exercise of warrants (in Shares)			1,288,730
Common stock issued upon conversion of preferred shares	0
Common stock issued upon conversion of preferred shares (in Shares)		(11,306)	5,653,000
Common stock issued for services	1,255				1,255
Common stock issued for services (in shares)			784,500
Common stock sold in private placement	32,241		$ 1		32,240
Common stock sold in private placement (in shares)			6,000,000
Unrealized gain on short-term investments	0
Net Loss	(12,035)						(12,035)
Ending Balance at Dec. 31, 2014	44,845	$ 0	$ 2	245	121,160	0	(76,562)
Ending Balance (in Shares) at Dec. 31, 2014		5,694	33,750,188
Common stock issued to induce exchange transaction	0
Fair value of vested stock options and warrants	6,752				6,752
Common stock issued upon exercise of warrants	9,705		$ 0		9,705
Common stock issued upon exercise of warrants (in Shares)			3,880,210
Common stock issued upon exercise of options	255		$ 0		255
Common stock issued upon exercise of options (in shares)			42,387
Common stock issued upon conversion of preferred shares	0		$ 0
Common stock issued upon conversion of preferred shares (in Shares)		(4,000)	2,000,000
Common stock sold in public offering, net of offering costs	68,307				68,307
Common stock sold in public offering, net of offering costs (in shares)			9,200,000
Common stock issued for services	1,771				1,771
Common stock issued for services (in shares)			15,000
Forfeiture and cancellation of restricted shares issued for services	0
Forfeiture and cancellation of restricted shares issued for services (in shares)			(340,065)
Unrealized gain on short-term investments	48					48
Net Loss	(27,660)						(27,660)
Ending Balance at Dec. 31, 2015	$ 104,023	$ 0	$ 2	$ 245	$ 207,950	$ 48	$ (104,222)
Ending Balance (in Shares) at Dec. 31, 2015		1,694	48,547,720

Statements of Stockholders' Eq8

Statements of Stockholders' Equity (Parenthetical) $ in Thousands	12 Months Ended
	Dec. 31, 2013USD ($)
Common Stock [Member]
Adjustments to Additional Paid in Capital, Stock Issued, Issuance Costs	$ 109

Statements of Cash Flows

Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Cash Flows From Operating Activities
Net Loss	$ (27,660)	$ (12,035)	$ (25,382)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	999	88	7
Fair value of vested stock options	6,752	2,559	747
Common stock issued for services	1,771	1,255	274
Common stock issued to induce exchange transaction	0	0	2,296
Common stock issued for Lion transaction	0	0	16,656
Common stock issued to directors	0	0	2,003
Changes in assets and liabilities:
Prepaid expenses and other current assets	(211)	108	(164)
Accounts payable and accrued expenses	(32)	(608)	(98)
Net cash used in operating activities	(18,381)	(8,633)	(3,661)
Cash Flows From Investing Activities
Increase in money market funds	(19,945)	0	0
Purchase of short-term investments	(140,665)	0	0
Maturities of short-term investments	70,600	0	0
Purchases of property and computer equipment	(1,143)	(1,592)	(13)
Net cash used in investing activities	(91,153)	(1,592)	(13)
Cash Flows From Financing Activities
Proceeds from the issuance of common stock upon exercise of warrants	9,705	3,222	0
Proceeds from the issuance of common stock upon exercise of options	255	0	0
Proceeds from the issuance of common stock, net	68,307	32,240	7,126
Proceeds from the issuance of convertible notes, net	0	0	311
Proceeds from the issuance of preferred stock, net	0	0	15,909
Net cash provided by financing activities	78,267	35,462	23,346
Net (decrease) increase in cash and cash equivalents	(31,267)	25,237	19,672
Cash and cash equivalents, beginning of period	44,909	19,672	0
Cash and cash equivalents, end of period	13,642	44,909	19,672
Supplemental Disclosures of Cash Flow Information:
Unrealized gain on short-term investments	48	0	0
Common stock issued upon conversion of convertible notes	0	0	6,793
Common stock issued upon conversion of accrued interest and penalty	$ 0	$ 0	$ 2,475

GENERAL ORGANIZATION AND BUSINE

GENERAL ORGANIZATION AND BUSINESS	12 Months Ended
	Dec. 31, 2015
Organization, Consolidation and Presentation of Financial Statements [Abstract]
GENERAL ORGANIZATION AND BUSINESS	NOTE 1. GENERAL ORGANIZATION AND BUSINESS Lion Biotechnologies, Inc. (the “Company,” “we,” “us” or “our”) is a biotechnology company focused on developing and commercializing adoptive cell therapy (ACT) using autologous tumor infiltrating lymphocytes (TIL) for the treatment of metastatic melanoma and other solid cancers. ACT utilizes T-cells harvested from a patient to treat cancer in that patient. TIL, a kind of anti-tumor T-cells that are naturally present in a patient’s tumors, are collected from individual patient tumor samples. The TIL are then activated and expanded ex vivo and then infused back into the patient to fight their tumor cells. The Company was originally incorporated under the laws of the state of Nevada on September 17, 2007. Until March 2010, we were an inactive company known as Freight Management Corp. On March 15, 2010, we changed our name to Genesis Biopharma, Inc., and in 2011 we commenced our current business. On September 26, 2013, we amended and restated our Articles of Incorporation to, among other things, change our name to Lion Biotechnologies, Inc., effect a 1-for-100 reverse stock split (pro-rata reduction of outstanding shares) of our common stock 150,000 50,000,000 0.001 Liquidity We are currently engaged in the development of therapeutics to fight cancer, we do not have any commercial products and have not yet generated any revenues from our biopharmaceutical business. We currently do not anticipate that we will generate any revenues during 2016 from the sale or licensing of any products. As shown in the accompanying financial statements, we have incurred a net loss of $ 27.7 18.4 103.7 104.0 102.3 During 2016, we expect to further ramp up our clinical operations which will increase the amount of cash we will use in our operations. Our budget for 2016 includes increased spending on Phase II clinical trials, research and development activities, higher payroll expenses as we increase our professional and scientific staff, as well as ongoing payments under our Cooperative Research and Development Agreement (CRADA) with the National Cancer Institute (NCI). Based on the funds we had available on December 31, 2015, we believe that we have sufficient capital to fund our anticipated operating expenses for at least 12 months. In March 2015, the Company sold 9,200,000 8.00 68.3 6,000,000 5.75 32.2 23.3

SUMMARY OF SIGNIFICANT ACCOUNTI

SUMMARY OF SIGNIFICANT ACCOUNTING PRACTICES	12 Months Ended
	Dec. 31, 2015
Accounting Policies [Abstract]
SUMMARY OF SIGNIFICANT ACCOUNTING PRACTICES	NOTE 2. SUMMARY OF SIGNIFICANT ACCOUNTING PRACTICES The Company considers all highly liquid investments with an original maturity of 90 days or less when purchased to be cash equivalents. The carrying amounts reported in the Balance Sheets for cash and cash equivalents are valued at cost, which approximates their fair value. The Company’s short-term investments represent available for sale securities and are recorded at fair value and unrealized gains and losses are recorded within accumulated other comprehensive income (loss). The estimated fair value of the available for sale securities is determined based on quoted market prices or rates for similar instruments. In addition, the cost of debt securities in this category is adjusted for amortization of premium and accretion of discount to maturity. The Company evaluates securities with unrealized losses to determine whether such losses, if any, are other than Property and equipment are stated at cost, net of accumulated depreciation and amortization. Computer equipment 2 Office furniture and equipment 5 Lab equipment 2 Leasehold improvements 5 Leasehold improvements are amortized using the straight-line method over the shorter of the estimated useful life of the asset or the lease term. Expenditures for maintenance and repairs are charged to operations as incurred while renewals and betterments are capitalized. Gains and losses on disposals are included in the consolidated statements of operations. Management assesses the carrying value of property and equipment whenever events or changes in circumstances indicate that the carrying value may not be recoverable. If there is indication of impairment, management prepares an estimate of future cash flows expected to result from the use of the asset and its eventual disposition. If these cash flows are less than the carrying amount of the asset, an impairment loss is recognized to write down the asset to its estimated fair value. For the years ended December 31, 2015 2014 and 2013, the Company did not recognize any impairments for its property and equipment. Basic earnings (loss) per share is computed by dividing the net income (loss) applicable to common stockholders by the weighted average number of shares of common stock outstanding during the period. Shares of restricted stock are included in the basic weighted average number of common shares outstanding from the time they vest. Diluted earnings (loss) per share is computed by dividing the net income (loss) applicable to common stockholders by the weighted average number of common shares outstanding plus the number of additional common shares that would have been outstanding if all dilutive potential common shares had been issued. Shares of restricted stock are included in the diluted weighted average number of common shares outstanding from the date they are granted unless they are antidilutive. For the years ended December 31, 2015, 2014, and 2013, the calculations of basic and diluted loss per share are the same because inclusion of potential dilutive securities in the computation would have an anti-dilutive effect due to the net losses. At December 31, 2015, 2014 and 2013, the dilutive impact of outstanding stock options for 2,693,237 1,857,877 278,750 7,202,216 11,084,426 12,373,156 847,000 2,847,000 0 Under FASB ASC 820, Fair Value Measurements and Disclosures Assets and liabilities recorded at fair value in our financial statements are categorized based upon the level of judgment associated with the inputs used to measure their fair value. Hierarchical levels directly related to the amount of subjectivity associated with the inputs to fair valuation of these assets and liabilities, are as follows: Level 1—Inputs are unadjusted, quoted prices in active markets for identical assets at the reporting date. Active markets are those in which transactions for the asset or liability occur in sufficient frequency and volume to provide pricing information on an ongoing basis. The fair valued assets we hold that are generally included under this Level 1 are money market securities where fair value is based on publicly quoted prices. Level 2—Are inputs, other than quoted prices included in Level 1, that are either directly or indirectly observable for the asset or liability through correlation with market data at the reporting date and for the duration of the instrument’s anticipated life. The fair valued assets we hold that are generally assessed under Level 2 are corporate bonds and commercial paper. We utilize third party pricing services in developing fair value measurements where fair value is based on valuation methodologies such as models using observable market inputs, including benchmark yields, reported trades, broker/dealer quotes, bids, offers and other reference data. We use quotes from external pricing service providers and other on-line quotation systems to verify the fair value of investments provided by our third party pricing service providers. We review independent auditor’s reports from our third party pricing service providers particularly regarding the controls over pricing and valuation of financial instruments and ensure that our internal controls address certain control deficiencies, if any, and complementary user entity controls are in place. Level 3—Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities and which reflect management’s best estimate of what market participants would use in pricing the asset or liability at the reporting date. Consideration is given to the risk inherent in the valuation technique and the risk inherent in the inputs to the model. We do not have fair valued assets classified under Level 3. The Company believes the carrying amount of its financial instruments (consisting of cash and cash equivalents, and accounts payable and accrued expenses) approximates fair value due to the short-term nature of such instruments. Assets at Fair Value as of December 31, 2015 Level 1 Level 2 Level 3 Total Money market funds $ 19,945 $ $ - $ 19,945 Corporate debt securities 70,113 - 70,113 Total $ 19,945 $ 70,113 $ - $ 90,058 The preparation of financial statements in conformity with accounting principles generally accepted in the United States of America requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of revenue and expenses during the reporting period. Actual results could differ from those estimates. Significant estimates include accounting for potential liabilities and the assumptions made in valuing stock instruments issued for services. The Company periodically grants stock options and warrants to employees and non-employees in non-capital raising transactions as compensation for services rendered. The Company accounts for stock option grants to employees based on the authoritative guidance provided by the Financial Accounting Standards Board where the value of the award is measured on the date of grant and recognized over the vesting period. The Company accounts for stock option grants to non-employees in accordance with the authoritative guidance of the Financial Accounting Standards Board where the value of the stock compensation is determined based upon the measurement date at either a) the date at which a performance commitment is reached, or b) at the date at which the necessary performance to earn the equity instruments is complete. Non-employee stock-based compensation charges generally are amortized over the vesting period on a straight-line basis. In certain circumstances where there are no future performance requirements by the non-employee, option grants are immediately vested and the total stock-based compensation charge is recorded in the period of the measurement date. The fair value of the Company's common stock option grants is estimated using a Black-Scholes option pricing model, which uses certain assumptions related to risk-free interest rates, expected volatility, expected life of the common stock options, and future dividends. Compensation expense is recorded based upon the value derived from the Black-Scholes option pricing model, and based on actual experience. The assumptions used in the Black-Scholes option pricing model could materially affect compensation expense recorded in future periods. The Company issues restricted shares of its common stock for share-based compensation programs. The Company measures the compensation cost with respect to restricted shares to employees based upon the estimated fair value of the equity instruments at the date of the grant, and is recognized as expense over the period which an employee is required to provide services in exchange for the award. For the Years Ended December 31, 2015 2014 2013 Research and development $ 2,248 $ 1,144 $ 825 General and administrative 6,275 2,670 1,925 Total stock-based compensation expense $ 8,523 $ 3,814 $ 2,750 Research and development costs consist primarily of compensation paid to employees engaged in research and development activities, fees paid to consultants and outside service providers, patent fees and costs, and other expenses relating to the acquisition, design, development and testing of the Company's treatments and product candidates. Research and development costs are expensed as incurred, or if applicable, over the life of the underlying contracts on the straight-line basis, unless the achievement of milestones, the completion of contracted work, or other information indicates that a different expensing schedule is more appropriate. The Company reviews the status of its research and development contracts on a quarterly basis. The Company accounts for income taxes using the asset and liability method whereby deferred tax assets are recognized for deductible temporary differences, and deferred tax liabilities are recognized for taxable temporary differences. Temporary differences are the differences between the reported amounts of assets and liabilities and their tax bases. Deferred tax assets are reduced by a valuation allowance when, in the opinion of management, it is more likely than not that some portion or all of the deferred tax assets will be realized. Deferred tax assets and liabilities are adjusted for the effects of changes in tax laws and rates on the date of enactment. Financial instruments, which potentially subject the Company to concentrations of credit risk, consist principally of cash. The Company maintains cash balances at one bank. At times, the amount on deposit exceeds the federally insured limits. Management believes that the financial institution that holds the Company’s cash is financially sound and, accordingly, minimal credit risk exists. As of December 31, 2015 and 2014, the Company’s cash balances were in excess of insured limits maintained at the bank. In February 2016, the FASB issued Accounting Standards Update (ASU) No. 2016-02, Leases. ASU 2016-02 requires a lessee to record a right of use asset and a corresponding lease liability on the balance sheet for all leases with terms longer than 12 months. ASU 2016-02 is effective for all interim and annual reporting periods beginning after December 15, 2018. Early adoption is permitted. A modified retrospective transition approach is required for lessees for capital and operating leases existing at, or entered into after, the beginning of the earliest comparative period presented in the financial statements, with certain practical expedients available. The Company is in the process of evaluating the impact of ASU 2016-02 on the Company’s financial statements and disclosures. In January 2016, the Financial Accounting Standards Board ("FASB") issued Accounting Standards Update (“ASU”) No. 2016-01, Recognition and Measurement of Financial Assets and Financial Liabilities In November 2015, the FASB issued Accounting Standards Update No. 2015-17, Income Taxes (Topic 740): Balance Sheet Classification of Deferred Taxes In June 2014, the FASB issued Accounting Standards Update No. 2014-12, Compensation – Stock Compensation (Topic 718). In May 2014, the FASB issued Accounting Standards Update No. 2014-09, Revenue from Contracts with Customers. Other recent accounting pronouncements issued by the FASB, including its Emerging Issues Task Force, the American Institute of Certified Public Accountants, and the Securities and Exchange Commission did not or are not believed by management to have a material impact on the Company's present or future consolidated financial statements. In presenting the Company’s statement of operations for the years ended December 31, 2014 and 2013, the Company has reclassified $ 1.1 0.8

CASH, MONEY MARKET FUNDS, AND S

CASH, MONEY MARKET FUNDS, AND SHORT-TERM INVESTMENTS	12 Months Ended
	Dec. 31, 2015
Cash, Cash Equivalents, and Short-term Investments [Abstract]
CASH, MONEY MARKET FUNDS, AND SHORT-TERM INVESTMENTS	NOTE 3. CASH, MONEY MARKET FUNDS, AND SHORT-TERM INVESTMENTS December 31, 2015 2014 Checking and savings accounts (reported as cash and cash equivalents) $ 13,642 $ 44,909 Money market funds 19,945 - Corporate debt securities (reported as short-term investments) 70,113 - $ 103,700 $ 44,909 Gross Gross Amortized Unrealized Unrealized December 31, 2015 Cost Gains Losses Fair Value Money market funds $ 19,945 $ - $ - $ 19,945 Corporate debt securities 70,065 48 - 70,113 Total $ 90,010 $ 48 $ - $ 90,058 Within One Year Money market funds $ 19,945 Corporate debt securities 70,113 $ 90,058 At December 31, 2015, the Company’s short-term investments were invested in short-term fixed income debt securities and notes of domestic and foreign high credit issuers and in money market funds. The Company’s investment policy limits investments to certain types of instruments such as certificates of deposit, money market instruments, obligations issued by the U.S. government and U.S. government agencies as well as corporate debt securities, and places restrictions on maturities and concentration by type and issuer. At December 31, 2015, the Company’s short-term investments totaled $ 70.1 43 37 20 19.9

PROPERTY AND EQUIPMENT

PROPERTY AND EQUIPMENT	12 Months Ended
	Dec. 31, 2015
Property, Plant and Equipment [Abstract]
PROPERTY AND EQUIPMENT	NOTE 4. PROPERTY AND EQUIPMENT December 31, 2015 2014 Lab equipment $ 1,703 $ 689 Computer equipment 85 72 Office furniture and equipment 138 113 Leasehold improvements 853 762 Total Property and equipment, cost 2,779 1,636 Less: Accumulated depreciation and amortization (1,103) (104) Property and equipment, net $ 1,676 $ 1,532 Depreciation expense for the years ended December 31, 2015, 2014 and 2013 was $ 999 7

STOCKHOLDERS' EQUITY

STOCKHOLDERS' EQUITY	12 Months Ended
	Dec. 31, 2015
Stockholders' Equity Note [Abstract]
STOCKHOLDERS’ EQUITY	NOTE 5. STOCKHOLDERS’ EQUITY On March 3, 2015, the Company completed an underwritten public offering of 9,200,000 8.00 68.3 On May 6, 2015, certain stockholders of the Company, including certain members of Board of Directors of the Company and their affiliates, sold 4,750,000 10.00 On December 22, 2014 the Company completed an underwritten public offering of 6,000,000 5.75 32.2 During 2015 and 2014, the Company granted 15,000 and 782,500 797,500 797,500 4.3 1.7 1.3 1.3 2.25 During 2015, certain employees authorized the Company to cancel 148,565 Weighted Average Number of Grant Date Shares Fair Value Non-vested shares, January 1, 2014 - $ - Granted 782,500 7.04 Vested - - Forfeited - - Non-vested shares, December 31, 2014 782,500 7.04 Granted 15,000 8.44 Vested (284,748) 4.31 Forfeited (191,500) 6.81 Non-vested shares, December 31, 2015 321,252 $ 6.96 In May 2013, the Company completed a transaction in which it cancelled certain debt and sold shares of common stock. As part of the transaction, certain investors purchasing common stock received as an inducement of 2,173,134 2.1 122,734 0.1 122,734 2.2 In July 2013, the Company issued 1,340,000 6.7 1,350,000 9.9 16.6 Series A Convertible Preferred Stock A total of 17,000 1,000 2.00 The Series A Preferred Stock may, at the option of the investor, be converted into fully paid and non-assessable shares of common stock. The holders of shares of Series A Preferred Stock shall not have the right to vote on matters that come before stockholders. In the event of any dissolution or winding up of the Company, proceeds shall be paid pari passu among the holders of the shares of common stock and preferred stock, pro rata based on the number of shares held by each holder. The Company may not declare, pay or set aside any dividends on shares of capital stock of the Company (other than dividends on shares of common stock payable in shares of common stock) unless the holders of the Series A Preferred Stock shall first receive an equal dividend on each outstanding share of Series A Preferred Stock. During the years ended December 31, 2015 and 2014, 4,000 11,306 2,000,000 5,653,000 500

STOCK OPTIONS AND WARRANTS

STOCK OPTIONS AND WARRANTS	12 Months Ended
	Dec. 31, 2015
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]
STOCK OPTIONS AND WARRANTS	NOTE 6. STOCK OPTIONS AND WARRANTS Stock Options Shares Under Option Weighted Weighted Aggregate Outstanding at January 1, 2013 93,750 $ 109.00 8.5 $ 217 Granted 225,000 104.00 Exercised - Expired/Forfeited (40,000) 92.00 Outstanding at December 31, 2013 278,750 23.10 9.1 1,176 Granted 1,604,127 6.58 Exercised - - Expired/Forfeited (25,000) 125.00 Outstanding at December 31, 2014 1,857,877 7.31 8.5 2,874 Granted 1,171,984 8.12 Exercised (42,387) - Expired/Forfeited (294,237) 2.88 Outstanding at December 31, 2015 2,693,237 $ 8.12 8.02 $ 2,347 Exercisable at December 31, 2015 1,099,043 $ 8.38 6.93 $ 1,487 During the year ended December 31, 2015, the Company granted options to purchase 1,171,984 10.1 207 218 1.57 6 During the years ended December 31, 2015, 2014, and 2013, the Company recorded compensation costs of $ 6.7 2.6 0.7 11.1 On September 19, 2014, the Company’s Board of Directors adopted the Lion Biotechnologies, Inc. 2014 Equity Incentive Plan (the “2014 Plan”). The 2014 Plan was approved by our stockholders at the annual meeting of stockholders held in November 2014. The 2014 Plan as approved by the stockholders authorized the issuance up to an aggregate of 2,350,000 1,650,000 4,000,000 Warrants Weighted Weighted Average Aggregate Shares Average Remaining Intrinsic Under Exercise Contractual Value Warrants Price Life (in thousands) Outstanding at January 1, 2013 108,734 $ 123.00 3.5 $ - Issued 12,387,156 2.50 Exercised - - Expired (122,734) Outstanding at December 31,2013 12,373,156 2.51 4.1 $ 31,056 Issued - Exercised (1,288,730) 2.50 Expired - Outstanding at December 31, 2014 11,084,426 2.51 3.9 59,518 Issued - - Exercised (3,882,210) 2.50 Expired - - Outstanding and exercisable at December 31, 2015 7,202,216 $ 2.51 3.3 $ 37,596 During the year ended December 31, 2015, the Company received $ 9.7 3,882,210

INCOME TAXES

INCOME TAXES	12 Months Ended
	Dec. 31, 2015
Income Tax Disclosure [Abstract]
INCOME TAXES	NOTE 7. INCOME TAXES The Company has no tax provision for any period presented due to our history of operating losses. As of December 31, 2015, the Company had state and federal net operating loss carry forwards of approximately $ 45 December 31, 2015 2014 Deferred income tax asset: Net operating loss carry forward $ 15,300 $ 8,428 Valuation allowance (15,300) (8,428) Net deferred income tax asset $ - $ - Year Ended December 31, 2015 2014 2013 Federal Statutory tax rate (34) % (34) % (34) % State tax, net of federal benefit (5) % (5) % (5) % (39) % (39) % (39) % Valuation allowance 39 % 39 % 39 % Effective tax rate - % - % - % The Company adopted accounting rules which address the determination of whether tax benefits claimed or expected to be claimed on a tax return should be recorded in the financial statements. Under these rules, the Company may recognize the tax benefit from an uncertain tax position only if it is more likely than not that the tax position will be sustained on examination by the taxing authorities, based on the technical merits of the position. The tax benefits recognized in the financial statements from such a position are measured based on the largest benefit that has a greater than fifty percent likelihood of being realized upon ultimate settlement. These accounting rules also provide guidance on de-recognition, classification, interest and penalties on income taxes, accounting in interim periods and requires increased disclosures. As of December 31, 2015, no liability for unrecognized tax benefits was required to be recorded.

LICENSES AND COMMITMENTS

LICENSES AND COMMITMENTS	12 Months Ended
	Dec. 31, 2015
Commitments and Contingencies Disclosure [Abstract]
LICENSES AND COMMITMENTS	NOTE 8. LICENSES AND COMMITMENTS National Institutes of Health and the National Cancer Institute Cooperative Research and Development Agreement Effective August 5, 2011, the Company signed a Cooperative Research and Development Agreement (CRADA) with the National Institutes of Health and the National Cancer Institute (NCI). Under the terms of the five-year cooperative research and development agreement, the Company will work with Dr. Steven A. Rosenberg, M.D., Ph.D., chief of NCI’s Surgery Branch, to develop adoptive cell immunotherapies that are designed to destroy metastatic melanoma cells using a patient’s tumor infiltrating lymphocytes. On January 22, 2015, the Company executed an amendment (the “Amendment”) to the CRADA to include four new indications. As amended, in addition to metastatic melanoma, the CRADA now also includes the development of TIL therapy for the treatment of patients with bladder, lung, triple-negative breast, and HPV-associated cancers. Under the Amendment, the NCI also has agreed to provide the Company with samples of all tumors covered by the Amendment for performing studies related to improving TIL selection and/or TIL scale-out production and process development. Although the CRADA has a five year term, either party to the CRADA has the right to terminate the CRADA upon 60 days’ notice to the other party. Development and Manufacture TIL Effective October 5, 2011, the Company entered into a Patent License Agreement with the National Institutes of Health, an agency of the United States Public Health Service within the Department of Health and Human Services (“NIH”), which License Agreement was subsequently amended on February 9, 2015 and October 2, 2015. Pursuant to the License Agreement as amended, NIH granted to the Company an exclusive worldwide right and license to develop and manufacture certain proprietary autologous tumor infiltrating lymphocyte adoptive cell therapy products for the treatment of metastatic melanoma, ovarian cancer, breast cancer, and colorectal cancer. The License Agreement requires the Company to pay royalties based on a percentage of net sales (which percentage is in the mid-single digits and subject to certain annual minimum royalty payments), a percentage of revenues from sublicensing arrangements, and lump sum benchmark royalty payments on the achievement of certain clinical and regulatory milestones for each of the various indications and other direct costs incurred by NIH pursuant to the agreement. Exclusive Patent License Agreement On February 10, 2015, the Company entered into an exclusive Patent License Agreement with the NIH under which the Company received an exclusive, world-wide license to the NIH’s rights in and to two patent-pending technologies related to methods for improving tumor-infiltrating lymphocytes for adoptive cell therapy. The licensed technologies relate to the more potent and efficient production of TIL from melanoma tumors by selecting for T-cell populations that express various inhibitory receptors. Unless terminated sooner, the license shall remain in effect until the last licensed patent right expires. In consideration for the exclusive rights granted under the exclusive Patent License Agreement, the Company agreed to pay the NIH a non-refundable upfront licensing fee which was recognized as research and development expense during the year ended December 31, 2015. The Company also agreed to pay customary royalties based on a percentage of net sales (which percentage is in the mid-single digits), a percentage of revenues from sublicensing arrangements, and lump sum benchmark payments upon the successful completion of the Company’s first Phase 2 clinical study, the successful completion of the Company’s first Phase 3 clinical study, the receipt of the first FDA approval or foreign equivalent for a licensed product or process resulting from the licensed technologies, the first commercial sale of a licensed product or process in the United States, and the first commercial sale of a licensed product or process in any foreign country. The Company will also be responsible for all costs associated with the preparation, filing, maintenance and prosecution of the patent applications and patents covered by the License. H. Lee Moffitt Cancer Center Research Collaboration Agreement In September 2014, the Company entered into a research collaboration agreement with the H. Lee Moffitt Cancer Center and Research Institute, Inc. to jointly engage in transitional research and development of adoptive tumor-infiltrating lymphocyte cell therapy with improved anti-tumor properties and process. Exclusive License Agreement The Company entered into an Exclusive License Agreement (the “Moffitt License Agreement”), effective as of June 28, 2014, with the H. Lee Moffitt Cancer Center and Research Institute, Inc. (“Moffitt”) under which the Company received an exclusive, world-wide license to Moffitt’s rights in and to two patent-pending technologies related to methods for improving tumor-infiltrating lymphocytes for adoptive cell therapy. Unless earlier terminated, the term of the license extends until the earlier of the expiration of the last patent related to the licensed technology or 20 years after the effective date of the license agreement. Pursuant to the Moffitt License Agreement, the Company paid an upfront licensing fee which was recognized as research and development expense during 2014. A patent issuance fee will also be payable under the Moffitt License Agreement, upon the issuance of the first U.S. patent covering the subject technology. In addition, the Company agreed to pay milestone license fees upon completion of specified milestones, customary royalties based on a specified percentage of net sales (which percentage is in the low single digits) and sublicensing payments, as applicable, and annual minimum royalties beginning with the first sale of products based on the licensed technologies, which minimum royalties will be credited against the percentage royalty payments otherwise payable in that year. The Company will also be responsible for all costs associated with the preparation, filing, maintenance and prosecution of the patent applications and patents covered by the Moffitt License Agreement related to the treatment of any cancers in the United States, Europe and Japan and in other countries selected that the Company and Moffitt agreed to. During the year ended December 31, 2015 and 2014, the Company recognized $ 3.8 1.4 Aggregate guaranteed commitments for 2016, under all of the Company’s license and research agreements, are approximately $ 2.1 Tampa Lease In July 2014, the Company entered into a five-year non-cancellable operating lease with the University of South Florida Research Foundation for an approximately 5,200 10,443 3 Year Amount 2016 $ 152 2017 157 2018 162 2019 167 $ 638

QUARTERLY UNAUDITED RESULTS

QUARTERLY UNAUDITED RESULTS	12 Months Ended
	Dec. 31, 2015
Quarterly Financial Information Disclosure [Abstract]
QUARTERLY UNAUDITED RESULTS	NOTE 9. QUARTERLY UNAUDITED RESULTS 2015 2014 (in thousands, except per share information) Q1 Q2 Q3 Q4 Q1 Q2 Q3 Q4 Revenue $ - $ - $ - $ - $ - $ - $ - $ - Net loss $ (5,298) $ (6,367) $ (7,635) $ (8,360) $ (2,260) $ (2,110) $ (3,014) $ (4,651) Net loss per share, basic and diluted $ (0.14) $ (0.14) $ (0.16) $ (0.18) $ (0.11) $ (0.09) $ (0.11) $ (0.17) Weighted average shares used in computing net loss per share, basic and diluted 37,679 45,082 47,272 47,912 20,798 24,138 26,633 28,271

LEGAL PROCEEDINGS

LEGAL PROCEEDINGS	12 Months Ended
	Dec. 31, 2015
Loss Contingency [Abstract]
LEGAL PROCEEDINGS	NOTE 10. LEGAL PROCEEDINGS On April 23, 2014, the Company received a subpoena from the Securities Exchange Commission (the “SEC”) that stated that the staff of the SEC is conducting an investigation In the Matter of Certain Stock Promotions The subpoena required us to give the SEC certain documents regarding, and communications between, anyone at this company and certain listed persons and entities (which include investor-relations firms and persons associated with the investor-relations firms), and articles regarding this company posted on certain equity research or other financial websites. We believe that the SEC is investigating improper conduct relative to the payment of bloggers and other authors for promotional articles written about public companies. A number of articles have been written about us that may be available on the internet and elsewhere. Investors considering an investment in our securities should review this Annual Report and the other documents that we filed with the SEC rather than relying on internet blogs or other similar articles and publications. Although we are unaware of the exact scope or timing of the SEC’s investigation, it is our understanding that the investigation is ongoing. We do not know when the investigation will be concluded or to what extent we will be further involved. If we receive additional subpoenas or other requests for documents from the SEC it is our intention to fully cooperate with the SEC. Complying with any such future requests could distract the time and attention of our officers and directors or divert our resources away from research and development programs. Furthermore, we, and our former officers and directors, may be the subject of the SEC’s investigation. Any such investigation could result in significant legal expenses, the diversion of management’s attention from our business, damage to our business and reputation, and could subject us to a wide range of remedies, including an SEC enforcement action and potential financial penalties required by the SEC. There are no other pending legal proceedings to which the Company is a party or of which its property is the subject.

SUMMARY OF SIGNIFICANT ACCOUN20

SUMMARY OF SIGNIFICANT ACCOUNTING PRACTICES (Policies)	12 Months Ended
	Dec. 31, 2015
Accounting Policies [Abstract]
Cash and Cash Equivalents	Cash and Cash Equivalents The Company considers all highly liquid investments with an original maturity of 90 days or less when purchased to be cash equivalents. The carrying amounts reported in the Balance Sheets for cash and cash equivalents are valued at cost, which approximates their fair value.
Short-term Investments	Short-term Investments The Company’s short-term investments represent available for sale securities and are recorded at fair value and unrealized gains and losses are recorded within accumulated other comprehensive income (loss). The estimated fair value of the available for sale securities is determined based on quoted market prices or rates for similar instruments. In addition, the cost of debt securities in this category is adjusted for amortization of premium and accretion of discount to maturity. The Company evaluates securities with unrealized losses to determine whether such losses, if any, are other than
Property and Equipment	Property and Equipment Property and equipment are stated at cost, net of accumulated depreciation and amortization. Computer equipment 2 Office furniture and equipment 5 Lab equipment 2 Leasehold improvements 5 Leasehold improvements are amortized using the straight-line method over the shorter of the estimated useful life of the asset or the lease term. Expenditures for maintenance and repairs are charged to operations as incurred while renewals and betterments are capitalized. Gains and losses on disposals are included in the consolidated statements of operations. Management assesses the carrying value of property and equipment whenever events or changes in circumstances indicate that the carrying value may not be recoverable. If there is indication of impairment, management prepares an estimate of future cash flows expected to result from the use of the asset and its eventual disposition. If these cash flows are less than the carrying amount of the asset, an impairment loss is recognized to write down the asset to its estimated fair value. For the years ended December 31, 2015 2014 and 2013, the Company did not recognize any impairments for its property and equipment.
Loss per Share	Loss per Share Basic earnings (loss) per share is computed by dividing the net income (loss) applicable to common stockholders by the weighted average number of shares of common stock outstanding during the period. Shares of restricted stock are included in the basic weighted average number of common shares outstanding from the time they vest. Diluted earnings (loss) per share is computed by dividing the net income (loss) applicable to common stockholders by the weighted average number of common shares outstanding plus the number of additional common shares that would have been outstanding if all dilutive potential common shares had been issued. Shares of restricted stock are included in the diluted weighted average number of common shares outstanding from the date they are granted unless they are antidilutive. For the years ended December 31, 2015, 2014, and 2013, the calculations of basic and diluted loss per share are the same because inclusion of potential dilutive securities in the computation would have an anti-dilutive effect due to the net losses. At December 31, 2015, 2014 and 2013, the dilutive impact of outstanding stock options for 2,693,237 1,857,877 278,750 7,202,216 11,084,426 12,373,156 847,000 2,847,000 0
Fair Value Measurements	Under FASB ASC 820, Fair Value Measurements and Disclosures Assets and liabilities recorded at fair value in our financial statements are categorized based upon the level of judgment associated with the inputs used to measure their fair value. Hierarchical levels directly related to the amount of subjectivity associated with the inputs to fair valuation of these assets and liabilities, are as follows: Level 1—Inputs are unadjusted, quoted prices in active markets for identical assets at the reporting date. Active markets are those in which transactions for the asset or liability occur in sufficient frequency and volume to provide pricing information on an ongoing basis. The fair valued assets we hold that are generally included under this Level 1 are money market securities where fair value is based on publicly quoted prices. Level 2—Are inputs, other than quoted prices included in Level 1, that are either directly or indirectly observable for the asset or liability through correlation with market data at the reporting date and for the duration of the instrument’s anticipated life. The fair valued assets we hold that are generally assessed under Level 2 are corporate bonds and commercial paper. We utilize third party pricing services in developing fair value measurements where fair value is based on valuation methodologies such as models using observable market inputs, including benchmark yields, reported trades, broker/dealer quotes, bids, offers and other reference data. We use quotes from external pricing service providers and other on-line quotation systems to verify the fair value of investments provided by our third party pricing service providers. We review independent auditor’s reports from our third party pricing service providers particularly regarding the controls over pricing and valuation of financial instruments and ensure that our internal controls address certain control deficiencies, if any, and complementary user entity controls are in place. Level 3—Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities and which reflect management’s best estimate of what market participants would use in pricing the asset or liability at the reporting date. Consideration is given to the risk inherent in the valuation technique and the risk inherent in the inputs to the model. We do not have fair valued assets classified under Level 3. The Company believes the carrying amount of its financial instruments (consisting of cash and cash equivalents, and accounts payable and accrued expenses) approximates fair value due to the short-term nature of such instruments.
Fair Value on a Recurring Basis	Fair Value on a Recurring Basis Assets at Fair Value as of December 31, 2015 Level 1 Level 2 Level 3 Total Money market funds $ 19,945 $ $ - $ 19,945 Corporate debt securities 70,113 - 70,113 Total $ 19,945 $ 70,113 $ - $ 90,058
Use of Estimates	Use of Estimates The preparation of financial statements in conformity with accounting principles generally accepted in the United States of America requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of revenue and expenses during the reporting period. Actual results could differ from those estimates. Significant estimates include accounting for potential liabilities and the assumptions made in valuing stock instruments issued for services.
Stock-Based Compensation	Stock-Based Compensation The Company periodically grants stock options and warrants to employees and non-employees in non-capital raising transactions as compensation for services rendered. The Company accounts for stock option grants to employees based on the authoritative guidance provided by the Financial Accounting Standards Board where the value of the award is measured on the date of grant and recognized over the vesting period. The Company accounts for stock option grants to non-employees in accordance with the authoritative guidance of the Financial Accounting Standards Board where the value of the stock compensation is determined based upon the measurement date at either a) the date at which a performance commitment is reached, or b) at the date at which the necessary performance to earn the equity instruments is complete. Non-employee stock-based compensation charges generally are amortized over the vesting period on a straight-line basis. In certain circumstances where there are no future performance requirements by the non-employee, option grants are immediately vested and the total stock-based compensation charge is recorded in the period of the measurement date. The fair value of the Company's common stock option grants is estimated using a Black-Scholes option pricing model, which uses certain assumptions related to risk-free interest rates, expected volatility, expected life of the common stock options, and future dividends. Compensation expense is recorded based upon the value derived from the Black-Scholes option pricing model, and based on actual experience. The assumptions used in the Black-Scholes option pricing model could materially affect compensation expense recorded in future periods. The Company issues restricted shares of its common stock for share-based compensation programs. The Company measures the compensation cost with respect to restricted shares to employees based upon the estimated fair value of the equity instruments at the date of the grant, and is recognized as expense over the period which an employee is required to provide services in exchange for the award. For the Years Ended December 31, 2015 2014 2013 Research and development $ 2,248 $ 1,144 $ 825 General and administrative 6,275 2,670 1,925 Total stock-based compensation expense $ 8,523 $ 3,814 $ 2,750
Research and Development	Research and Development Research and development costs consist primarily of compensation paid to employees engaged in research and development activities, fees paid to consultants and outside service providers, patent fees and costs, and other expenses relating to the acquisition, design, development and testing of the Company's treatments and product candidates. Research and development costs are expensed as incurred, or if applicable, over the life of the underlying contracts on the straight-line basis, unless the achievement of milestones, the completion of contracted work, or other information indicates that a different expensing schedule is more appropriate. The Company reviews the status of its research and development contracts on a quarterly basis.
Income taxes	Income taxes The Company accounts for income taxes using the asset and liability method whereby deferred tax assets are recognized for deductible temporary differences, and deferred tax liabilities are recognized for taxable temporary differences. Temporary differences are the differences between the reported amounts of assets and liabilities and their tax bases. Deferred tax assets are reduced by a valuation allowance when, in the opinion of management, it is more likely than not that some portion or all of the deferred tax assets will be realized. Deferred tax assets and liabilities are adjusted for the effects of changes in tax laws and rates on the date of enactment.
Concentrations	Concentrations Financial instruments, which potentially subject the Company to concentrations of credit risk, consist principally of cash. The Company maintains cash balances at one bank. At times, the amount on deposit exceeds the federally insured limits. Management believes that the financial institution that holds the Company’s cash is financially sound and, accordingly, minimal credit risk exists. As of December 31, 2015 and 2014, the Company’s cash balances were in excess of insured limits maintained at the bank.
Recent Accounting Pronouncements	Recent Accounting Pronouncements In February 2016, the FASB issued Accounting Standards Update (ASU) No. 2016-02, Leases. ASU 2016-02 requires a lessee to record a right of use asset and a corresponding lease liability on the balance sheet for all leases with terms longer than 12 months. ASU 2016-02 is effective for all interim and annual reporting periods beginning after December 15, 2018. Early adoption is permitted. A modified retrospective transition approach is required for lessees for capital and operating leases existing at, or entered into after, the beginning of the earliest comparative period presented in the financial statements, with certain practical expedients available. The Company is in the process of evaluating the impact of ASU 2016-02 on the Company’s financial statements and disclosures. In January 2016, the Financial Accounting Standards Board ("FASB") issued Accounting Standards Update (“ASU”) No. 2016-01, Recognition and Measurement of Financial Assets and Financial Liabilities In November 2015, the FASB issued Accounting Standards Update No. 2015-17, Income Taxes (Topic 740): Balance Sheet Classification of Deferred Taxes In June 2014, the FASB issued Accounting Standards Update No. 2014-12, Compensation – Stock Compensation (Topic 718). In May 2014, the FASB issued Accounting Standards Update No. 2014-09, Revenue from Contracts with Customers. Other recent accounting pronouncements issued by the FASB, including its Emerging Issues Task Force, the American Institute of Certified Public Accountants, and the Securities and Exchange Commission did not or are not believed by management to have a material impact on the Company's present or future consolidated financial statements.
Reclassifications	Reclassifications In presenting the Company’s statement of operations for the years ended December 31, 2014 and 2013, the Company has reclassified $ 1.1 0.8

SUMMARY OF SIGNIFICANT ACCOUN21

SUMMARY OF SIGNIFICANT ACCOUNTING PRACTICES (Tables)	12 Months Ended
	Dec. 31, 2015
Accounting Policies [Abstract]
Schedule of Assets Measured at Fair Value	Financial assets measured at fair value on a recurring basis are categorized in the tables below based upon the lowest level of significant input to the valuations (in thousands): Assets at Fair Value as of December 31, 2015 Level 1 Level 2 Level 3 Total Money market funds $ 19,945 $ $ - $ 19,945 Corporate debt securities 70,113 - 70,113 Total $ 19,945 $ 70,113 $ - $ 90,058
Schedule of Stock-Based Compensation	Total stock-based compensation expense related to all of our stock-based awards was as follows (in thousands): For the Years Ended December 31, 2015 2014 2013 Research and development $ 2,248 $ 1,144 $ 825 General and administrative 6,275 2,670 1,925 Total stock-based compensation expense $ 8,523 $ 3,814 $ 2,750

CASH, MONEY MARKET FUNDS, AND22

CASH, MONEY MARKET FUNDS, AND SHORT-TERM INVESTMENTS (Tables)	12 Months Ended
	Dec. 31, 2015
Cash, Cash Equivalents, and Short-term Investments [Abstract]
Schedule of Cash, Money Market Funds and Short-Term Investments	Cash, money market funds, and short-term investments consist of the following (in thousands): December 31, 2015 2014 Checking and savings accounts (reported as cash and cash equivalents) $ 13,642 $ 44,909 Money market funds 19,945 - Corporate debt securities (reported as short-term investments) 70,113 - $ 103,700 $ 44,909
Schedule of Unrealized Gains and Losses	Money market funds and short-term investments include the following securities with gross unrealized gains and losses (in thousands): Gross Gross Amortized Unrealized Unrealized December 31, 2015 Cost Gains Losses Fair Value Money market funds $ 19,945 $ - $ - $ 19,945 Corporate debt securities 70,065 48 - 70,113 Total $ 90,010 $ 48 $ - $ 90,058
Schedule of Contractual Maturities	As of December 31, 2015, the contractual maturities of our money market funds and short-term investments were (in thousands): Within One Year Money market funds $ 19,945 Corporate debt securities 70,113 $ 90,058

PROPERTY AND EQUIPMENT (Tables)

PROPERTY AND EQUIPMENT (Tables)	12 Months Ended
	Dec. 31, 2015
Property, Plant and Equipment [Abstract]
Schedule of Property, Plant and Equipment	Property and equipment consisted of the following (in thousands): December 31, 2015 2014 Lab equipment $ 1,703 $ 689 Computer equipment 85 72 Office furniture and equipment 138 113 Leasehold improvements 853 762 Total Property and equipment, cost 2,779 1,636 Less: Accumulated depreciation and amortization (1,103) (104) Property and equipment, net $ 1,676 $ 1,532

STOCKHOLDERS' EQUITY (Tables)

STOCKHOLDERS' EQUITY (Tables)	12 Months Ended
	Dec. 31, 2015
Stockholders' Equity Note [Abstract]
Schedule of Restricted Stock Activity	The following table summarizes restricted common stock activity: Weighted Average Number of Grant Date Shares Fair Value Non-vested shares, January 1, 2014 - $ - Granted 782,500 7.04 Vested - - Forfeited - - Non-vested shares, December 31, 2014 782,500 7.04 Granted 15,000 8.44 Vested (284,748) 4.31 Forfeited (191,500) 6.81 Non-vested shares, December 31, 2015 321,252 $ 6.96

STOCK OPTIONS AND WARRANTS (Tab

STOCK OPTIONS AND WARRANTS (Tables)	12 Months Ended
	Dec. 31, 2015
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]
Schedule of Status of Stock Options	A summary of the status of stock options at December 31, 2015, and the changes during the year ended, is presented in the following table: Shares Under Option Weighted Weighted Aggregate Outstanding at January 1, 2013 93,750 $ 109.00 8.5 $ 217 Granted 225,000 104.00 Exercised - Expired/Forfeited (40,000) 92.00 Outstanding at December 31, 2013 278,750 23.10 9.1 1,176 Granted 1,604,127 6.58 Exercised - - Expired/Forfeited (25,000) 125.00 Outstanding at December 31, 2014 1,857,877 7.31 8.5 2,874 Granted 1,171,984 8.12 Exercised (42,387) - Expired/Forfeited (294,237) 2.88 Outstanding at December 31, 2015 2,693,237 $ 8.12 8.02 $ 2,347 Exercisable at December 31, 2015 1,099,043 $ 8.38 6.93 $ 1,487
Schedule of Status of Stock Warrants	A summary of the status of stock warrants at December 31, 2015, and the changes during the year then ended, is presented in the following table: Weighted Weighted Average Aggregate Shares Average Remaining Intrinsic Under Exercise Contractual Value Warrants Price Life (in thousands) Outstanding at January 1, 2013 108,734 $ 123.00 3.5 $ - Issued 12,387,156 2.50 Exercised - - Expired (122,734) Outstanding at December 31,2013 12,373,156 2.51 4.1 $ 31,056 Issued - Exercised (1,288,730) 2.50 Expired - Outstanding at December 31, 2014 11,084,426 2.51 3.9 59,518 Issued - - Exercised (3,882,210) 2.50 Expired - - Outstanding and exercisable at December 31, 2015 7,202,216 $ 2.51 3.3 $ 37,596

INCOME TAXES (Tables)

INCOME TAXES (Tables)	12 Months Ended
	Dec. 31, 2015
Income Tax Disclosure [Abstract]
Schedule of Deferred Tax Assets and Liabilities	Significant components of the Company’s deferred income tax assets are as follows as of (in thousands): December 31, 2015 2014 Deferred income tax asset: Net operating loss carry forward $ 15,300 $ 8,428 Valuation allowance (15,300) (8,428) Net deferred income tax asset $ - $ -
Schedule of Effective Income Tax Rate Reconciliation	Reconciliation of the effective income tax rate to the U.S. statutory rate is as follows: Year Ended December 31, 2015 2014 2013 Federal Statutory tax rate (34) % (34) % (34) % State tax, net of federal benefit (5) % (5) % (5) % (39) % (39) % (39) % Valuation allowance 39 % 39 % 39 % Effective tax rate - % - % - %

LICENSES AND COMMITMENTS (Table

LICENSES AND COMMITMENTS (Tables)	12 Months Ended
	Dec. 31, 2015
Commitments and Contingencies Disclosure [Abstract]
Schedule of Recorded Unconditional Purchase Obligations	The minimum lease payments are as follows (in thousands): Year Amount 2016 $ 152 2017 157 2018 162 2019 167 $ 638

QUARTERLY UNAUDITED RESULTS (Ta

QUARTERLY UNAUDITED RESULTS (Tables)	12 Months Ended
	Dec. 31, 2015
Quarterly Financial Information Disclosure [Abstract]
Schedule of Quarterly Financial Information	The results of operations by quarter for the years ended December 31, 2015 and 2014 are as follow: 2015 2014 (in thousands, except per share information) Q1 Q2 Q3 Q4 Q1 Q2 Q3 Q4 Revenue $ - $ - $ - $ - $ - $ - $ - $ - Net loss $ (5,298) $ (6,367) $ (7,635) $ (8,360) $ (2,260) $ (2,110) $ (3,014) $ (4,651) Net loss per share, basic and diluted $ (0.14) $ (0.14) $ (0.16) $ (0.18) $ (0.11) $ (0.09) $ (0.11) $ (0.17) Weighted average shares used in computing net loss per share, basic and diluted 37,679 45,082 47,272 47,912 20,798 24,138 26,633 28,271

GENERAL ORGANIZATION AND BUSI29

GENERAL ORGANIZATION AND BUSINESS (Details Textual) - USD ($) $ / shares in Units, $ in Thousands	Mar. 03, 2015	Mar. 31, 2015	Dec. 31, 2014	Dec. 22, 2014	Nov. 30, 2013	Sep. 30, 2013	Jul. 31, 2013	Dec. 31, 2015	Sep. 30, 2015	Jun. 30, 2015	Mar. 31, 2015	Dec. 31, 2014	Sep. 30, 2014	Jun. 30, 2014	Mar. 31, 2014	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013	Sep. 26, 2013	Dec. 31, 2012
Net Income (Loss) Attributable to Parent, Total								$ (8,360)	$ (7,635)	$ (6,367)	$ (5,298)	$ (4,651)	$ (3,014)	$ (2,110)	$ (2,260)	$ (27,660)	$ (12,035)	$ (25,382)
Net Cash Provided by (Used in) Operating Activities, Continuing Operations, Total																(18,381)	(8,633)	(3,661)
Cash, Cash Equivalents, and Short-term Investments, Total			$ 44,909					103,700				44,909				103,700	44,909
Stockholders' Equity Attributable to Parent, Total			$ 44,845					104,023				$ 44,845				104,023	$ 44,845	17,603		$ (11,319)
Working Capital								$ 102,300								102,300
Stock Issued During Period, Shares, New Issues		9,200,000	6,000,000
Share Price		$ 8	$ 5.75								$ 8	$ 5.75					$ 5.75
Proceeds from Issuance of Common Stock		$ 68,300		$ 32,200												$ 68,307	$ 32,240	7,126
Proceeds from Issuance of Private Placement					$ 23,300
Stockholders' Equity, Reverse Stock Split						1-for-100
Common Stock, Shares Authorized			150,000,000					150,000,000				150,000,000				150,000,000	150,000,000		150,000
Preferred Stock, Shares Authorized			50,000,000					50,000,000				50,000,000				50,000,000	50,000,000		50,000,000
Preferred Stock, Par or Stated Value Per Share			$ 0.001					$ 0.001				$ 0.001				$ 0.001	$ 0.001		$ 0.001
Common Stock [Member]
Stockholders' Equity Attributable to Parent, Total			$ 2					$ 2				$ 2				$ 2	$ 2	$ 1		$ 0
Stock Issued During Period, Shares, New Issues	9,200,000			6,000,000			1,340,000									9,200,000
Share Price	$ 8			$ 5.75
Stockholders' Equity, Reverse Stock Split						On September 26, 2013, we amended and restated our Articles of Incorporation to, among other things, change our name to Lion Biotechnologies, Inc., effect a 1-for-100 reverse stock split (pro-rata reduction of outstanding shares) of our common stock

SUMMARY OF SIGNIFICANT ACCOUN30

SUMMARY OF SIGNIFICANT ACCOUNTING PRACTICES (Details) - Fair Value, Measurements, Recurring [Member] $ in Thousands	Dec. 31, 2015USD ($)
Assets, fair value	$ 90,058
Corporate Debt Securities [Member]
Assets, fair value	70,113
Money Market Funds [Member]
Assets, fair value	19,945
Fair Value, Inputs, Level 1 [Member]
Assets, fair value	19,945
Fair Value, Inputs, Level 1 [Member] | Money Market Funds [Member]
Assets, fair value	19,945
Fair Value, Inputs, Level 2 [Member]
Assets, fair value	70,113
Fair Value, Inputs, Level 2 [Member] | Corporate Debt Securities [Member]
Assets, fair value	70,113
Fair Value, Inputs, Level 3 [Member]
Assets, fair value	0
Fair Value, Inputs, Level 3 [Member] | Corporate Debt Securities [Member]
Assets, fair value	0
Fair Value, Inputs, Level 3 [Member] | Money Market Funds [Member]
Assets, fair value	$ 0

SUMMARY OF SIGNIFICANT ACCOUN31

SUMMARY OF SIGNIFICANT ACCOUNTING PRACTICES (Details 1) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost, Total	$ 8,523	$ 3,814	$ 2,750
Research and Development Expense [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost, Total	2,248	1,144	825
General and Administrative Expense [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost, Total	$ 6,275	$ 2,670	$ 1,925

SUMMARY OF SIGNIFICANT ACCOUN32

SUMMARY OF SIGNIFICANT ACCOUNTING PRACTICES (Details Textual) - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Reclassification Of Stock Based Compensation Cost		$ 1.1	$ 0.8
Stock Option Shares Outstanding	2,693,237	1,857,877	278,750
Class of Warrant or Right, Outstanding	7,202,216	11,084,426	12,373,156
Computer Equipment [Member]
Property, Plant and Equipment, Useful Life	2 years
Office Furniture and Equipment [Member]
Property, Plant and Equipment, Useful Life	5 years
Lab Equipment [Member]
Property, Plant and Equipment, Useful Life	2 years
Leasehold Improvements [Member]
Property, Plant and Equipment, Useful Life	5 years
Convertible Preferred Stock [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount	847,000	2,847,000	0

CASH, MONEY MARKET FUNDS, AND33

CASH, MONEY MARKET FUNDS, AND SHORT-TERM INVESTMENTS (Details) - USD ($) $ in Thousands	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013	Dec. 31, 2012
Checking and savings accounts (reported as cash and cash equivalents)	$ 13,642	$ 44,909	$ 19,672	$ 0
Money market funds	19,945	0
Corporate debt securities (reported as short-term investments)	70,113	0
Total	$ 103,700	$ 44,909

CASH, MONEY MARKET FUNDS, AND34

CASH, MONEY MARKET FUNDS, AND SHORT-TERM INVESTMENTS (Details 1) $ in Thousands	12 Months Ended
	Dec. 31, 2015USD ($)
Amortized Cost	$ 90,010
Gross Unrealized Gains	48
Gross Unrealized Losses	0
Fair Value	90,058
Corporate Debt Securities [Member]
Amortized Cost	70,065
Gross Unrealized Gains	48
Gross Unrealized Losses	0
Fair Value	70,113
Money Market Funds [Member]
Amortized Cost	19,945
Gross Unrealized Gains	0
Gross Unrealized Losses	0
Fair Value	$ 19,945

CASH, MONEY MARKET FUNDS, AND35

CASH, MONEY MARKET FUNDS, AND SHORT-TERM INVESTMENTS (Details 2) - USD ($) $ in Thousands	Dec. 31, 2015	Dec. 31, 2014
Money market funds	$ 19,945	$ 0
Corporate debt securities	70,113	$ 0
Total	$ 90,058

CASH, MONEY MARKET FUNDS, AND36

CASH, MONEY MARKET FUNDS, AND SHORT-TERM INVESTMENTS (Details Textual) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014
Available-for-sale Securities, Total	$ 70,113	$ 0
Money Market Funds, at Carrying Value	$ 19,945	$ 0
Money Market Funds And Short TermInvestments Weighted Average Time To Maturity	66 days
Short-term Investments [Member] | Five Companies [Member]
Concentration Risk, Percentage	43.00%
Short-term Investments [Member] | Various Other Domestic Issuers [Member]
Concentration Risk, Percentage	37.00%
Short-term Investments [Member] | Foreign Issuer [Member]
Concentration Risk, Percentage	20.00%

PROPERTY AND EQUIPMENT (Details

PROPERTY AND EQUIPMENT (Details) - USD ($) $ in Thousands	Dec. 31, 2015	Dec. 31, 2014
Total Property and equipment, cost	$ 2,779	$ 1,636
Less: Accumulated depreciation and amortization	(1,103)	(104)
Property and equipment, net	1,676	1,532
Lab Equipment [Member]
Total Property and equipment, cost	1,703	689
Computer Equipment [Member]
Total Property and equipment, cost	85	72
Office Furniture and Equipment [Member]
Total Property and equipment, cost	138	113
Leasehold Improvements [Member]
Total Property and equipment, cost	$ 853	$ 762

PROPERTY AND EQUIPMENT (Detai38

PROPERTY AND EQUIPMENT (Details Textual) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Depreciation, Total	$ 999	$ 88	$ 7

STOCKHOLDER'S EQUITY (Details)

STOCKHOLDER'S EQUITY (Details) - $ / shares	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014
Number of Shares
Non-vested shares, Beginning Balance	782,500	0
Granted	15,000	782,500
Vested	(284,748)	0
Forfeited	(191,500)	0
Non-vested shares, Ending Balance	321,252	782,500
Weighted Average Grant Date Fair Value
Weighted Average Grant Date Fair Value, Beginning Balance	$ 7.04	$ 0
Granted	8.44	7.04
Vested	4.31	0
Forfeited	6.81	0
Weighted Average Grant Date Fair Value, Ending Balance	$ 6.96	$ 7.04

STOCKHOLDERS' EQUITY (Details T

STOCKHOLDERS' EQUITY (Details Textual) - USD ($) $ / shares in Units, $ in Thousands	May. 06, 2015	Mar. 03, 2015	Mar. 31, 2015	Dec. 31, 2014	Dec. 22, 2014	Jul. 31, 2013	Dec. 31, 2013	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013	Sep. 26, 2013
Class of Stock [Line Items]
Stock Issued During Period, Shares, New Issues			9,200,000	6,000,000
Share Price			$ 8	$ 5.75					$ 5.75
Proceeds from Issuance of Common Stock			$ 68,300		$ 32,200			$ 68,307	$ 32,240	$ 7,126
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period								15,000	782,500
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period								284,748	0
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period								3 years
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term								2 years 3 months
Cancellation Of Vested Shares								148,565
Aggregate Fair Value Cost of Induce Exchange Transation								$ 2,200		$ 16,600
Stock Issued During Period, Value, New Issues								$ 68,307
Preferred Stock, Par or Stated Value Per Share				$ 0.001				$ 0.001	$ 0.001		$ 0.001
Proceeds from Issuance Initial Public Offering									$ 32,200
Warrant to Aaquired										122,734
Board of Directors Chairman [Member]
Class of Stock [Line Items]
Stock Issued During Period, Shares, New Issues	4,750,000
Share Price	$ 10
Common Stock [Member]
Class of Stock [Line Items]
Stock Issued During Period, Shares, New Issues		9,200,000			6,000,000	1,340,000		9,200,000
Share Price		$ 8			$ 5.75
Stock Issued During Period, Value, New Issues						$ 6,700
Common Stock [Member] | Issuance Of Common Stock Upon Conversion Of Preferred Stock [Member]
Class of Stock [Line Items]
Conversion of Stock, Shares Issued								4,000	11,306
Conversion of Stock, Shares Converted								2,000,000	5,653,000
Conversion of Stock, Description								The common shares issued were determined on a formula basis of 500 common shares for each share of Series A Convertible Preferred Stock converted.
Investor [Member] | Common Stock [Member]
Class of Stock [Line Items]
Stock Issued During Period, Shares, New Issues								2,173,134
Stock Issued During Period, Value, New Issues								$ 2,100
Two Owners [Member] | Common Stock [Member]
Class of Stock [Line Items]
Stock Issued During Period, Shares, New Issues							1,350,000
Stock Issued During Period, Value, New Issues							$ 9,900
Creditor [Member] | Common Stock [Member]
Class of Stock [Line Items]
Stock Issued During Period, Shares, New Issues								122,734
Stock Issued During Period, Value, New Issues								$ 100
Restricted Stock [Member]
Class of Stock [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period									782,500
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period								797,500
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Vested in Period, Fair Value								$ 4,300
Employee Service Share-based Compensation, Nonvested Awards, Compensation Not yet Recognized, Share-based Awards Other than Options								$ 1,300
Series A Convertible Preferred Stock [Member]
Class of Stock [Line Items]
Conversion of Stock, Shares Issued								500
Series A Convertible Preferred Stock [Member] | Private Placement [Member]
Class of Stock [Line Items]
Stock Issued During Period, Shares, New Issues								17,000
Sale of Stock, Price Per Share								$ 2
Preferred Stock, Par or Stated Value Per Share								$ 1,000

STOCK OPTIONS AND WARRANTS (Det

STOCK OPTIONS AND WARRANTS (Details) - Employee Stock Option [Member] - USD ($) $ / shares in Units, $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013	Dec. 31, 2012
Shares Under Option
Outstanding, beginning balance	1,857,877	278,750	93,750
Granted	1,171,984	1,604,127	225,000
Exercised	(42,387)	0	0
Expired/Forfeited	(294,237)	(25,000)	(40,000)
Outstanding, ending balance	2,693,237	1,857,877	278,750	93,750
Exercisable	1,099,043
Weighted Average Exercise Price
Outstanding, beginning balance	$ 7.31	$ 23.10	$ 109
Granted	8.12	6.58	104
Exercised	0	0
Expired/Forfeited	2.88	125	92
Outstanding, ending balance	8.12	$ 7.31	$ 23.10	$ 109
Exercisable	$ 8.38
Weighted Average Remaining Contractual Life
Outstanding	8 years 7 days	8 years 6 months	9 years 1 month 6 days	8 years 6 months
Exercisable	6 years 11 months 5 days
Aggregate Intrinsic Value
Outstanding, beginning balance	$ 2,874	$ 1,176	$ 217
Outstanding, ending balance	2,347	$ 2,874	$ 1,176	$ 217
Exercisable	$ 1,487

STOCK OPTIONS AND WARRANTS (D42

STOCK OPTIONS AND WARRANTS (Details 1) - Warrant [Member] - USD ($) $ / shares in Units, $ in Thousands	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013	Dec. 31, 2012
Shares Under Warrants
Outstanding, beginning balance	11,084,426	12,373,156	108,734
Issued	0	0	12,387,156
Exercised	(3,882,210)	(1,288,730)	0
Expired	0	0	(122,734)
Outstanding, ending balance	7,202,216	11,084,426	12,373,156	108,734
Weighted Average Exercise Price
Outstanding, beginning balance	$ 2.51	$ 2.51	$ 123
Issued	0		2.50
Exercised	2.5	2.50	0
Expired	0
Outstanding, ending balance	$ 2.51	$ 2.51	$ 2.51	$ 123
Weighted Average Remaining Contractual Life
Outstanding	3 years 3 months 18 days	3 years 10 months 24 days	4 years 1 month 6 days	3 years 6 months
Aggregate Intrinsic Value
Outstanding, beginning balance	$ 59,518	$ 31,056	$ 0
Outstanding, ending balance	$ 37,596	$ 59,518	$ 31,056	$ 0

STOCK OPTIONS AND WARRANTS (D43

STOCK OPTIONS AND WARRANTS (Details Textual) - USD ($) $ in Thousands	Apr. 10, 2015	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013	Nov. 30, 2014
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Allocated Share-based Compensation Expense		$ 6,700	$ 2,600	$ 700
Proceeds from Warrant Exercises		9,705	$ 3,222	$ 0
Employee Service Share-based Compensation, Nonvested Awards, Compensation Not yet Recognized, Stock Options		$ 11,100
Warrant [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross		0	0	12,387,156
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period		3,882,210	1,288,730	0
2014 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized					2,350,000
Share-based Compensation Arrangement by Share-based Payment Award, Number of Additional Shares Authorized	1,650,000
2014 [Member] | Shares Issued Three [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized		4,000,000
Employee Stock Option [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross		1,171,984
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested in Period, Fair Value		$ 10,100
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Maximum		218.00%
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate, Maximum		1.57%
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term		6 years
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate, Minimum		207.00%

INCOME TAXES (Details)

INCOME TAXES (Details) - USD ($) $ in Thousands	Dec. 31, 2015	Dec. 31, 2014
Deferred income tax asset:
Net operating loss carry forward	$ 15,300	$ 8,428
Valuation allowance	(15,300)	(8,428)
Net deferred income tax asset	$ 0	$ 0

INCOME TAXES (Details 1)

INCOME TAXES (Details 1)	12 Months Ended
	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Federal Statutory tax rate	(34.00%)	(34.00%)	(34.00%)
State tax, net of federal benefit	(5.00%)	(5.00%)	(5.00%)
Effective Income Tax Rate Reconciliation Expected Rate Total	(39.00%)	(39.00%)	(39.00%)
Valuation allowance	39.00%	39.00%	39.00%
Effective tax rate	0.00%	0.00%	0.00%

INCOME TAXES (Details Textual)

INCOME TAXES (Details Textual) $ in Millions	Dec. 31, 2015USD ($)
Income Tax Contingency [Line Items]
Tax Credit Carryforward, Amount	$ 45

LICENSES AND COMMITMENTS (Detai

LICENSES AND COMMITMENTS (Details)	Dec. 31, 2015USD ($)
2,016	$ 152
2,017	157
2,018	162
2,019	167
Total	$ 638

LICENSES AND COMMITMENTS (Det48

LICENSES AND COMMITMENTS (Details Textual)	12 Months Ended
	Dec. 31, 2015USD ($)a	Dec. 31, 2014USD ($)
License And Commitments [Line Items]
License Costs	$ 3,800,000	$ 1,400,000
License and Research Agreements [Member]
License And Commitments [Line Items]
Contractual Obligation, Due in Next Fiscal Year	$ 2,100,000
Tampa Lease [Member]
License And Commitments [Line Items]
Area of Land | a	5,200
Operating Leases, Rent Expense	$ 10,443
Percentage Of Increase In Lease Rent	3.00%

QUARTERLY UNAUDITED RESULTS (De

QUARTERLY UNAUDITED RESULTS (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended								12 Months Ended
	Dec. 31, 2015	Sep. 30, 2015	Jun. 30, 2015	Mar. 31, 2015	Dec. 31, 2014	Sep. 30, 2014	Jun. 30, 2014	Mar. 31, 2014	Dec. 31, 2015	Dec. 31, 2014	Dec. 31, 2013
Revenue	$ 0	$ 0	$ 0	$ 0	$ 0	$ 0	$ 0	$ 0	$ 0	$ 0	$ 0
Net loss	$ (8,360)	$ (7,635)	$ (6,367)	$ (5,298)	$ (4,651)	$ (3,014)	$ (2,110)	$ (2,260)	$ (27,660)	$ (12,035)	$ (25,382)
Net loss per share, basic and diluted	$ (0.18)	$ (0.16)	$ (0.14)	$ (0.14)	$ (0.17)	$ (0.11)	$ (0.09)	$ (0.11)	$ (0.62)	$ (0.48)	$ (3.47)
Weighted average shares used in computing net loss per share, basic and diluted	47,912	47,272	45,082	37,679	28,271	26,633	24,138	20,798	44,410,036	24,985,542	9,762,513