Bristol-Myers Squibb (BMY) 8-K Changes in Registrant.s Certifying Accountant

Exhibit 16.1

March 17, 2006

Securities and Exchange Commission

100 F Street, N.E.

Washington, DC 20549

Commissioners:

We have read the statements made by Bristol-Myers Squibb Puerto Rico, Inc. Savings and Investment Program (copy attached), which we understand will be filed with the Securities and Exchange Commission, pursuant to Item 4.01 of Form 8-K, as part of the Form 8-K of Bristol-Myers Squibb Puerto Rico, Inc. Savings and Investment Program dated March 14, 2006. We agree with the statements concerning our Firm in such Form 8-K.

Very truly yours,

/s/ PricewaterhouseCoopers LLP

PricewaterhouseCoopers LLP

Philadelphia, Pennsylvania