Zevra Therapeutics (ZVRA) 10-Q 12 May 22 2022 Q1 Quarterly report Financial data

Document And Entity Information

Document And Entity Information - shares	3 Months Ended
	Mar. 31, 2022	May 11, 2022
Document Information [Line Items]
Entity Central Index Key	0001434647
Entity Registrant Name	KEMPHARM, INC
Amendment Flag	false
Current Fiscal Year End Date	--12-31
Document Fiscal Period Focus	Q1
Document Fiscal Year Focus	2022
Document Type	10-Q
Document Quarterly Report	true
Document Period End Date	Mar. 31, 2022
Document Transition Report	false
Entity File Number	001-36913
Entity Incorporation, State or Country Code	DE
Entity Tax Identification Number	20-5894398
Entity Address, Address Line One	1180 Celebration Boulevard, Suite 103
Entity Address, City or Town	Celebration
Entity Address, State or Province	FL
Entity Address, Postal Zip Code	34747
City Area Code	321
Local Phone Number	939-3416
Title of 12(b) Security	Common Stock, $0.0001 par value per share
Trading Symbol	KMPH
Security Exchange Name	NASDAQ
Entity Current Reporting Status	Yes
Entity Interactive Data Current	Yes
Entity Filer Category	Non-accelerated Filer
Entity Small Business	true
Entity Emerging Growth Company	false
Entity Shell Company	false
Entity Common Stock, Shares Outstanding		34,423,497

Condensed Balance Sheets (Curre

Condensed Balance Sheets (Current Period Unaudited) - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021
Assets
Cash and cash equivalents	$ 100,242	$ 112,346
Marketable securities	1,338	0
Accounts and other receivables	3,320	1,528
Prepaid expenses and other current assets	880	1,182
Total current assets	105,780	115,056
Property and equipment, net	835	884
Operating lease right-of-use assets	1,090	1,141
Long-term investments	17,564	15,422
Other long-term assets	437	438
Total assets	125,706	132,941
Liabilities and stockholders' equity
Accounts payable and accrued expenses	2,582	3,038
Current portion of operating lease liabilities	356	356
Other current liabilities	7	836
Total current liabilities	2,945	4,230
Derivative and warrant liability	89	330
Operating lease liabilities, less current portion	1,144	1,232
Other long-term liabilities	29	31
Total liabilities	4,207	5,823
Commitments and contingencies (Note D)
Stockholders’ equity:
Common stock, $0.0001 par value, 250,000,000 shares authorized, 35,333,450 shares issued and 34,423,497 shares outstanding as of March 31, 2022 (unaudited); 35,325,801 shares issued and 35,005,640 shares outstanding as of December 31, 2021	3	4
Additional paid-in capital	397,925	396,957
Treasury stock, at cost	(7,536)	(2,814)
Accumulated deficit	(268,893)	(267,029)
Total stockholders' equity	121,499	127,118
Total liabilities and stockholders' equity	125,706	132,941
Undesignated Preferred Stock [Member]
Stockholders’ equity:
Undesignated preferred stock, $0.0001 par value, 10,000,000 shares authorized, no shares issued or outstanding as of March 31, 2022 (unaudited) or December 31, 2021	$ 0	$ 0

Condensed Balance Sheets (Cur_2

Condensed Balance Sheets (Current Period Unaudited) (Parentheticals) - $ / shares	Mar. 31, 2022	Dec. 31, 2021
Preferred stock, shares authorized (in shares)	10,000,000	10,000,000
Preferred stock, shares issued (in shares)	0	0
Preferred stock, shares outstanding (in shares)	0	0
Common stock, par value (in dollars per share)	$ 0.0001	$ 0.0001
Common stock, shares authorized (in shares)	250,000,000	250,000,000
Common stock, shares issued (in shares)	35,333,450	35,325,801
Common stock, shares outstanding (in shares)	34,423,497	35,005,640
Undesignated Preferred Stock [Member]
Preferred stock, par value (in dollars per share)	$ 0.0001	$ 0.0001
Preferred stock, shares authorized (in shares)	10,000,000	10,000,000
Preferred stock, shares issued (in shares)	0	0
Preferred stock, shares outstanding (in shares)	0	0

Unaudited Condensed Statements

Unaudited Condensed Statements of Operations - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Revenue	$ 3,965	$ 12,117
Operating expenses:
Royalty and direct contract acquisition costs	8	1,000
Research and development	3,082	2,265
General and administrative	2,734	1,892
Total operating expenses	5,824	5,157
(Loss) income from operations	(1,859)	6,960
Other (expense) income:
Loss on extinguishment of debt	0	(16,885)
Interest expense related to amortization of debt issuance costs and discount	0	(150)
Interest expense on principal	(5)	(199)
Fair value adjustment related to derivative and warrant liability	241	(30)
Interest and other (expense) income, net	(245)	8
Total other expenses	(9)	(17,256)
Loss before income taxes	(1,868)	(10,296)
Income tax benefit	4	0
Net income (loss)	(1,864)	(10,296)
Deemed dividend	0	(37,444)
Net loss attributable to common stockholders	$ (1,864)	$ (47,740)
Basic and diluted net loss per share of common stock:
Net loss attributable to common stockholders (in dollars per share)	$ (0.05)	$ (2.49)
Weighted average number of shares of common stock outstanding:
Basic and diluted (in shares)	34,506,597	19,146,270

Unaudited Condensed Statement_2

Unaudited Condensed Statements of Changes in Stockholders' Equity (Deficit) - USD ($) $ in Thousands	Preferred Stock [Member]Series A Convertible Preferred Stock [Member]Underwritten Public Offering [Member]	Preferred Stock [Member]Series A Convertible Preferred Stock [Member]January 2021 Inducement Warrants [Member]	Preferred Stock [Member]Series A Convertible Preferred Stock [Member]Warrants to Purchase Common Stock [Member]	Preferred Stock [Member]Series A Convertible Preferred Stock [Member]Exchange Warrants [Member]	Preferred Stock [Member]Series A Convertible Preferred Stock [Member]Conversion of Facility Notes into Series B-2 Preferred Stock [Member]	Preferred Stock [Member]Series A Convertible Preferred Stock [Member]Conversion of Series B-2 Preferred Stock into Common Stock [Member]	Preferred Stock [Member]Series A Convertible Preferred Stock [Member]	Preferred Stock [Member]Series B-1 Convertible Preferred Stock [Member]Underwritten Public Offering [Member]	Preferred Stock [Member]Series B-1 Convertible Preferred Stock [Member]January 2021 Inducement Warrants [Member]	Preferred Stock [Member]Series B-1 Convertible Preferred Stock [Member]Warrants to Purchase Common Stock [Member]	Preferred Stock [Member]Series B-1 Convertible Preferred Stock [Member]Exchange Warrants [Member]	Preferred Stock [Member]Series B-1 Convertible Preferred Stock [Member]Conversion of Facility Notes into Series B-2 Preferred Stock [Member]	Preferred Stock [Member]Series B-1 Convertible Preferred Stock [Member]Conversion of Series B-2 Preferred Stock into Common Stock [Member]	Preferred Stock [Member]Series B-1 Convertible Preferred Stock [Member]	Preferred Stock [Member]Series B-2 Convertible Preferred Stock [Member]Underwritten Public Offering [Member]	Preferred Stock [Member]Series B-2 Convertible Preferred Stock [Member]January 2021 Inducement Warrants [Member]	Preferred Stock [Member]Series B-2 Convertible Preferred Stock [Member]Warrants to Purchase Common Stock [Member]	Preferred Stock [Member]Series B-2 Convertible Preferred Stock [Member]Exchange Warrants [Member]	Preferred Stock [Member]Series B-2 Convertible Preferred Stock [Member]Conversion of Facility Notes into Series B-2 Preferred Stock [Member]	Preferred Stock [Member]Series B-2 Convertible Preferred Stock [Member]Conversion of Series B-2 Preferred Stock into Common Stock [Member]	Preferred Stock [Member]Series B-2 Convertible Preferred Stock [Member]	Preferred Stock [Member]Undesignated Preferred Stock [Member]	Undesignated Preferred Stock [Member]Underwritten Public Offering [Member]	Undesignated Preferred Stock [Member]January 2021 Inducement Warrants [Member]	Undesignated Preferred Stock [Member]Warrants to Purchase Common Stock [Member]	Undesignated Preferred Stock [Member]Exchange Warrants [Member]	Undesignated Preferred Stock [Member]Conversion of Facility Notes into Series B-2 Preferred Stock [Member]	Undesignated Preferred Stock [Member]Conversion of Series B-2 Preferred Stock into Common Stock [Member]	Undesignated Preferred Stock [Member]	Common Stock [Member]Underwritten Public Offering [Member]	Common Stock [Member]January 2021 Inducement Warrants [Member]	Common Stock [Member]Warrants to Purchase Common Stock [Member]	Common Stock [Member]Exchange Warrants [Member]	Common Stock [Member]Conversion of Facility Notes into Series B-2 Preferred Stock [Member]	Common Stock [Member]Conversion of Series B-2 Preferred Stock into Common Stock [Member]	Common Stock [Member]	Additional Paid-in Capital [Member]Underwritten Public Offering [Member]	Additional Paid-in Capital [Member]January 2021 Inducement Warrants [Member]	Additional Paid-in Capital [Member]Warrants to Purchase Common Stock [Member]	Additional Paid-in Capital [Member]Exchange Warrants [Member]	Additional Paid-in Capital [Member]Conversion of Facility Notes into Series B-2 Preferred Stock [Member]	Additional Paid-in Capital [Member]Conversion of Series B-2 Preferred Stock into Common Stock [Member]	Additional Paid-in Capital [Member]	Retained Earnings [Member]Underwritten Public Offering [Member]	Retained Earnings [Member]January 2021 Inducement Warrants [Member]	Retained Earnings [Member]Warrants to Purchase Common Stock [Member]	Retained Earnings [Member]Exchange Warrants [Member]	Retained Earnings [Member]Conversion of Facility Notes into Series B-2 Preferred Stock [Member]	Retained Earnings [Member]Conversion of Series B-2 Preferred Stock into Common Stock [Member]	Retained Earnings [Member]	Treasury Stock [Member]	Underwritten Public Offering [Member]	January 2021 Inducement Warrants [Member]	Warrants to Purchase Common Stock [Member]	Exchange Warrants [Member]	Conversion of Facility Notes into Series B-2 Preferred Stock [Member]	Conversion of Series B-2 Preferred Stock into Common Stock [Member]	Total
Balance at Dec. 31, 2020							$ 0							$ 0							$ 0								$ 0							$ 0							$ 192,062							$ (258,474)								$ (66,412)
Net income (loss)							0							0							0								0							0							0							(10,296)								(10,296)
Stock-based compensation expense							0							0							0								0							0							675							0								675
Issuance of common stock in exchange for consulting services							0							0							0								0							0							82							0								82
Issuance of common stock in connection with Public Offering, net of discounts and commissions	$ 0							$ 0							$ 0								$ 0							$ 1							$ 49,284							$ 0								$ 49,285
Issuance of common stock in connection with the exercise of warrants in the Inducement Transaction, net of discounts and commissions		$ 0							$ 0							$ 0								$ 0							$ 1							$ 40,390							$ 0								$ 40,391
Issuance of common stock in connection with the exercise of common stock warrants			$ 0							$ 0							$ 0								$ 0							$ 0							$ 25,593							$ 0								$ 25,593
Fair value of warrants issued		0		$ 0					0		$ 0					0		$ 0						0		$ 0					0		$ 0					38,437		$ 15,990					0		$ 0						38,437		$ 15,990
Issuance of stock as a result of conversion					$ 0	$ 0						$ 0	$ 0						$ 29,056	$ (29,056)							$ 0	$ 0						$ 0	$ 1						$ 0	$ 29,055						$ 0	$ 0							$ 0	$ 29,056
Deemed dividend related the Inducement Transaction		$ 0							$ 0							$ 0								$ 0							$ 0							$ (37,444)							$ 0								$ (37,444)
Offering expenses charged to equity							0							0							0								0							0							(1,106)							0								(1,106)
Balance at Mar. 31, 2021							$ 0							$ 0							$ 0								$ 0							3							353,018							(268,770)								84,251
Balance at Dec. 31, 2021																						$ 0														4							396,957							(267,029)	$ (2,814)							127,118
Net income (loss)																						0														0							0							(1,864)	0							(1,864)
Stock-based compensation expense																						0														0							918							0	0							918
Shares repurchased as part of the Share Repurchase Program																						0																					0							0	(4,722)							(4,723)
Shares repurchased as part of the Share Repurchase Program																																				(1)
Issuance of common stock in exchange for consulting services																						0														0							50							0	0							50
Balance at Mar. 31, 2022																						$ 0														$ 3							$ 397,925							$ (268,893)	$ (7,536)							$ 121,499

Unaudited Condensed Statement_3

Unaudited Condensed Statements of Cash Flows - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Cash flows from operating activities:
Net loss	$ (1,864)	$ (10,296)
Adjustments to reconcile net loss to net cash used in operating activities:
Loss on extinguishment of debt	0	16,885
Stock-based compensation expense	918	675
Amortization of debt issuance costs and debt discount	0	150
Depreciation and amortization expense	65	64
Fair value adjustment related to derivative and warrant liability	(241)	30
Fair value adjustment related to marketable securities and long-term investments	352	0
Consulting fees paid in common stock	50	82
Change in assets and liabilities:
Accounts and other receivables	(1,792)	(8,729)
Prepaid expenses and other assets	303	273
Operating lease right-of-use assets	51	56
Accounts payable and accrued expenses	(418)	(1,820)
Operating lease liabilities	(88)	(78)
Other liabilities	(821)	122
Net cash used in operating activities	(3,485)	(2,586)
Cash flows from investing activities:
Purchases of property and equipment	(16)	0
Purchases of marketable securities and long-term investments	(3,832)	0
Net cash used in investing activities	(3,848)	0
Cash flows from financing activities:
Proceeds from Public Offering, net of discounts and commissions	0	49,285
Payment to repurchase shares as part of the Share Repurchase Program	(4,723)	0
Payment of offering costs	(68)	(1,106)
Repayment of principal on finance lease liabilities	(10)	(61)
Payment of debt issuance costs	0	(2,881)
Repayment of principal on convertible notes	0	(37,924)
Net proceeds from exercise of common stock warrants	0	25,593
Net cash (used in) provided by financing activities	(4,801)	74,290
Net (decrease) increase in cash, cash equivalents and restricted cash	(12,134)	71,704
Cash, cash equivalents and restricted cash, beginning of period	112,346	4,322
Cash, cash equivalents and restricted cash, end of period	100,212	76,026
Supplemental cash flow information:
Cash paid for interest	5	199
Amounts due for property and equipment included in accounts payable and accrued expenses	0	4
Amounts due for deferred offering costs included in accounts payable and accrued expenses	0	17
Fair value of warrants issued to underwriters in connection with Public Offering	0	3,485
Conversion of Facility Notes into Series B-2 Preferred Stock [Member]
Supplemental cash flow information:
Notes principal converted	0	31,477
Warrants Issued in Connection with January 2021 Inducement Transaction [Member]
Cash flows from financing activities:
Proceeds from Inducement Transaction, net of discounts and commissions	$ 0	$ 41,384

Note A - Description of Busines

Note A - Description of Business and Basis of Presentation	3 Months Ended
	Mar. 31, 2022
Notes to Financial Statements
Business Description and Basis of Presentation [Text Block]	A. Description of Business and Basis of Presentation Organization KemPharm, Inc. (the "Company") is a specialty pharmaceutical company focused on the discovery and development of treatments for central nervous system ("CNS") and rare disease indications that allow the Company to target high-value areas with significant unmet needs. The Company's core competency is the discovery and development of proprietary prodrugs to treat serious medical conditions through its proprietary Ligand Activated Therapy ("LAT ® may ® KP415, six KP1077, KP879. The accompanying unaudited condensed financial statements have been prepared in accordance with accounting principles generally accepted in the United States of America ("U.S. GAAP") for interim financial information and with the instructions to Form 10 8 03 X. not three March 31, 2022 not may December 31, 2022. This interim information should be read in conjunction with the audited financial statements included in the Company’s Annual Report on Form 10 December 31, 2021, March 31, 2022. Basis of Presentation The Company prepared the financial statements in accordance with United States generally accepted accounting principles (“GAAP”) and the rules and regulations of the United States Securities and Exchange Commission (the "SEC") and, in the Company's opinion, reflect all adjustments, including normal recurring items that are necessary. Underwriting Agreement On January 8, 2021, 1 No. 333 250945 On January 8, 2021, February 1, 2021, On January 12, 2021, On January 25, 2022, 1 No. 333 250945 3 February 1, 2022. Listing on the Nasdaq Stock Market On January 7, 2021, January 8, 2021, On October 19, 2021, October 19, 2021, January 2021. Entry into 2021 ATM Agreement On July 2, 2021, "2021 may 2021 3. may 415 1933, may 2021 3 2021 July 12, 2021. March 31, 2022, 2021 Share Repurchase Program On December 20, 2021, may December 31, 2023. KP415 may 10b 18 1934, not may not March 31, 2022,

Note B - Summary of Significant

Note B - Summary of Significant Accounting Policies	3 Months Ended
	Mar. 31, 2022
Notes to Financial Statements
Significant Accounting Policies [Text Block]	B. Summary of Significant Accounting Policies Use of Estimates The preparation of financial statements in conformity with U.S. GAAP requires the Company to make estimates and assumptions that affect the amounts reported in the financial statements and accompanying notes. Actual results could differ from those estimates. On an ongoing basis, the Company evaluates its estimates and assumptions, including those related to revenue recognition, the useful lives of property and equipment, the recoverability of long-lived assets, the incremental borrowing rate for leases, and assumptions used for purposes of determining stock-based compensation, income taxes, the fair value of long-term investments and the fair value of the derivative and warrant liability, among others. The Company bases its estimates on historical experience and on various other assumptions that it believes to be reasonable, the results of which form the basis for making judgments about the carrying value of assets and liabilities. Revenue Recognition The Company commenced recognizing revenue in accordance with the provisions of ASC 606, Revenue from Contracts with Customers 606” January 1, 2018. Arrangements with Multiple-Performance Obligations From time to time, the Company enters into arrangements for research and development, manufacturing and/or commercialization services. Such arrangements may In arrangements involving more than one not The consideration allocated to each distinct performance obligation is recognized as revenue when control of the related goods or services is transferred. Consideration associated with at-risk substantive performance milestones is recognized as revenue when it is probable that a significant reversal of the cumulative revenue recognized will not Licensing Agreements The Company enters into licensing agreements with licensees that fall under the scope of ASC 606. The terms of the Company’s licensing agreements typically include one may As part of the accounting for these agreements, the Company must develop estimates and assumptions that require judgment to determine the underlying stand-alone selling price for each performance obligation which determines how the transaction price is allocated among the performance obligations. Generally, the estimation of the stand-alone selling price may Up-front Fees: Milestone Payments: not not not may KP415 In September 2019, “KP415 KP415 KP484, KP879, KP922 KP484, KP415 KP484; KP415 KP415 In April 2021, No. 1 KP415 "KP415 KP415 KP415 KP415 KP415 March 2, 2021. May 7, 2021. KP415 KP415 KP415 Pursuant to the KP415 first KP922, no Commave also agreed to be responsible for and reimburse the Company for all of the development, commercialization and regulatory expenses incurred on the licensed products, subject to certain limitations as set forth in the KP415 In accordance with the terms of the Company’s March 20, 2012 KP484, KP879 KP1077 KP415 The KP415 606, not KP415 606, third two $10.0 KP415 The consideration allocated to the grant of the exclusive, worldwide license was $10.0 KP415 KP415 Under the KP415 first 1 may may KP415 KP415 not third 606 not not The Company is entitled to additional payments from Commave conditioned upon the achievement of specified regulatory milestones related to AZSTARYS and KP484 KP415 KP415 not not not Per the KP415 March 2021, May 2021. two 2021, first second 2021, 340 40, Contracts with Customers first second 2021. For the three March 31, 2022, 2021, KP415 March 31, 2022, December 31, 2021. Consulting Arrangements The Company enters into consulting arrangements with third 606. may third Corium Consulting Agreement In July 2020, KP415 Under the Corium Consulting Agreement, the Company is entitled to receive payments from Corium of up to $15.6 million, $13.6 million of which was earned in monthly installments through March 31, 2022 first 2022 March 31, 2022. The Corium Consulting Agreement is within the scope of ASC 606, not 606, third third not not not The Company determined that the performance of consulting services, including reimbursement of third third 606 March 31, 2022, third For the three March 31, 2022, 2021, March 31, 2022, December 31, 2021, Other Consulting Arrangements The Company recognized no revenue under other consulting arrangements for the three March 31, 2022. three March 31, 2021, March 31, 2022, December 31, 2021. Accounts and Other Receivables Accounts and other receivables consist of receivables under the KP415 KP415 third March 31, 2022, KP415 December 31, 2021, KP415 March 31, 2022, December 31, 2021, no Application of New or Revised Accounting Standards—Adopted From time to time, the Financial Accounting Standards Board (the “FASB”) or other standard-setting bodies issue accounting standards that are adopted by the Company as of the specified effective date. In August 2020, 2020 06, Debt Debt with Conversion and Other Options (Subtopic 470 20 and Derivatives and Hedging Contracts in Entity s Own Equity (Subtopic 815 40 Accounting for Convertible Instruments and Contracts in an Entity s Own Equity 2020 06” December 15, 2021, 2020 06 not In May 2021, 2021 04, Earnings Per Share (Topic 260 470 50 718 815 40 2021 04” December 15, 2021, 2021 04 not

Note C - Debt Obligations

Note C - Debt Obligations	3 Months Ended
	Mar. 31, 2022
Notes to Financial Statements
Debt Disclosure [Text Block]	C. Debt Obligations As of March 31, 2022 December 31, 2021, Deerfield Facility Agreement In June 2014, first December 2020, The Deerfield Convertible Note originally bore interest at 9.75% per annum but was subsequently reduced to 6.75%. Interest accrued on the outstanding balance under the Deerfield Convertible Note was due quarterly in arrears. The Company originally had to repay one third fourth fifth June 2018 June 2019). June 2018, September 2019, June 1, 2020 “2021 September 2019”). December 2019, March 31, 2021, “2021 December 2019”). March 31, 2021. not Pursuant to the Deerfield Facility Agreement, the Company issued to Deerfield a warrant to purchase 14,423,076 shares of Series D Preferred at an initial exercise price of $0.78 per share, which is exercisable until June 2, 2024 December 2020, January 2021 June 2021 January 2021 June 2021 260, may The Company recorded the fair value of the shares of Series D Preferred to debt issuance costs on the date of issuance. The Company also recorded the fair value of the Deerfield Warrant and the embedded Warrant Put Option to debt discount on the date of issuance. The debt issuance costs and debt discount were amortized over the term of the related debt and the expense was recorded as interest expense related to amortization of debt issuance costs and discount in the statements of operations. In the first 2021, 2 Pursuant to the Deerfield Facility Agreement, the Company was not Issuance of 5.50% Senior Convertible Notes and Third Amendment to Senior Secured Convertible Note and Warrant In February 2016, 2021 “2021 2021 144A 1933, The 2021 February 9, 2016 2021 February 1 August 1 August 1, 2016, 5.50% 2021 February 1, 2021 The net proceeds from the Note Offering were approximately $82.8 million, after deducting the Initial Purchasers’ discount and estimated offering expenses. Concurrent with the Note Offering, the Company used approximately $18.6 million of the net proceeds from the Note Offering to repay in full the Term Note, plus all accrued but unpaid interest, a make-whole interest payment and a prepayment premium on the Term Note. The 2021 not 2021 2021 2021 December 2020, 2021 2021 If the Company underwent a “fundamental change” (as defined in the Indenture), holders could have required that the Company repurchase for cash all or any portion of their 2021 2021 The Indenture included customary terms and covenants, including certain events of default after which the 2021 may As described in more detail below, in multiple exchanges occurring in December 2019 January 2020, 2021 2021 December 2019 In December 2019, December 2019 “December 2019 “December 2019 December 2019 “December 2019 2021 December 2019 December 2019 December 18, 2019, 2021 December 2019 December 2019 The December 2019 December 2019 2021 December 2019 December 2020, December 2019 December 2019 December 2019 December 2019 415 December 2019 $93.60 not x 2020 September 2019 December 2019 not December 2019 December 2019 December 2019 December 2019 4.985% December 2019 December 2019 December 2019 March 31, 2021, not December 2019 December 2019 December 2019 December 2019 December 2019 December 2019 The December 2019 December 2019 December 2019 December 2019 February 14, 2020 June 1, 2020, March 31, 2021, March 31, 2021 may The December 2019 December 2019 December 2019 $93.60 December 2019 The December 2019 December 2019 The December 2019 December 2019 may one In connection with entering into the December 2019 December 18, 2019, June 2, 2014, In connection with entering into the December 2019 “September 2019 September 2019 September 2019 December 2019 September 2019 September 2019 x 15 no September 2019 2 September 2019 may September 2019 September 2019 September December 2020, 15 In connection with entering into the September 2019 2 2 2 2 September 2019 $9.60 15 As of September 30, 2020, December 2019 The Company determined the changes to the Deerfield Convertible Note met the definition of a troubled debt restructuring under ASC 470 60, no The changes to the 2021 December 2019 December 2019 December 2019 2021 January 2020 In January 2020, January 2020 “January 2020 January 2020 “January 2020 2021 January 2020 January 13, 2020, 2021 January 2020 The January 2020 December 2019 In connection with entering into the January 2020 December 2019 “December 2019 December 2019 December 2019 December 2019 December 2019 x 2020 December 2020, The changes to the 2021 January 2020 January 2020 January 2020 December 2020 Rights Agreement In December 2020, December 2020 “December 2020 December 2020 December 2019 January 2020 January 1, 2021, December 2020 2 Q4 December 2020 “December 2020 The December 2020 not March 31, 2023. Subject to the satisfaction or waiver of certain conditions specified in the December 2020 December 2020 June 2, 2014, March 31, 2023, ( July 1, 2021, The December 2020 February 19, 2015 ( December 2020 The Exchange Warrants issued pursuant to the December 2020 75% 2 1 No. 333 250945 4.985% In anticipation of the Public Offering, and to meet the Nasdaq Listing Requirements, the Company agreed in December 2020 December 2019 January 2020 December 31, 2020. Under the terms of the December 2020 January 12, 2021, ● Exchanged $31.5 million of the outstanding principal and accrued interest on the Facility Notes for (i) 31,476.98412 shares of Series B- 2 ● Made a payment of $30.3 million (the "Debt Payment"), in partial repayment of the remaining outstanding principal and accrued interest of the Facility Notes. Following the completion of these transactions, the aggregate balance of principal and accrued interest remaining outstanding under the Facility Notes was approximately $7.6 million. With respect to this remaining outstanding balance under the Facility Notes, the December 2020 ● The maturity date was changed to March 31, 2023, ● Interest would accrue at the rate of 6.75% per annum, payable quarterly, would be added to principal until June 30, 2021, The changes to the Facility Notes, under the December 2020 December 2020 December 2020 not three March 31, 2021, The transactions contemplated under the December 2020 2 2 As a condition to closing of the December 2020 2 2 2 Each share of Series B- 2 $1,000 The Series B- 2 2 2 4.985% 2 not 2 $1,000 2 2 2 2 2 2 not 2 not not 2 2 2 2 Payoff of Facility Agreement Notes and Termination of Facility Agreement On February 8, 2021, Pursuant to the payoff letter, the Company paid a total of $8.0 million to the Facility Agreement Note Holders, representing the principal balance, accrued interest outstanding and a prepayment fee in repayment of the Company’s outstanding obligations under the Facility Agreement. Pursuant to the payoff letter, all outstanding indebtedness and obligations of the Company owing to the Facility Agreement Note Holders under the Facility Agreement have been paid in full. The Facility Agreement and the notes thereunder, as well as the security interests in the assets of the Company securing the Facility Agreement and note obligations, have been terminated. The Facility Agreement Note Holders will retain the warrants previously issued to them by the Company. The Company determined the payoff letter met the liability derecognition threshold under ASC 405 20, Liabilities - Extinguishment of Liabilities no three March 31, 2021. PPP Loan On April 23, 2020, may May 2021,

Note D - Commitments and Contin

Note D - Commitments and Contingencies	3 Months Ended
	Mar. 31, 2022
Notes to Financial Statements
Commitments and Contingencies Disclosure [Text Block]	D. Commitments and Contingencies From time to time, the Company is involved in various legal proceedings arising in the normal course of business. For some matters, a liability is not not March 31, 2022 December 31, 2021

Note E - Preferred Stock and Wa

Note E - Preferred Stock and Warrants	3 Months Ended
	Mar. 31, 2022
Notes to Financial Statements
Preferred Stock [Text Block]	E. Preferred Stock and Warrants Authorized, Issued, and Outstanding Preferred Stock As of March 31, 2022, December 31, 2021, In June 2021, 1 1 2 2 March 31, 2022, December 31, 2021, Series B- 2 Pursuant to the December 2020 January 12, 2021, 2 The Series B- 2 No 2 2 Amended and Restated Certificate of Designation of Preferences, Rights and Limitations of the Series B- 2 Convertible Preferred Stock On January 11, 2021, December 2020 2 2 2 Immediately following, the closing of the Public Offering, pursuant to the terms of the December 2020 ● Exchanged approximately $31.5 million (the "Exchange") of the outstanding principal and accrued interest on the Facility Notes for (i) the Series B- 2 ● made a payment of approximately $30.3 million (the “Debt Payment”) in partial repayment of the remaining outstanding principal and accrued interest on the Facility Notes. Upon the closing of the Exchange and related Debt Payment, the amendments to the Facility Agreement, the Notes and the Investors’ Rights Agreement, dated as of February 19, 2015, December 2020 2 2 January 12, 2021. In March 2021, 2

Note F - Common Stock and Warra

Note F - Common Stock and Warrants	3 Months Ended
	Mar. 31, 2022
Notes to Financial Statements
Stockholders' Equity Note Disclosure [Text Block]	F. Common Stock and Warrants Authorized, Issued, and Outstanding Common Shares As of March 31, 2022 December 31, 2021 March 31, 2022, December 31, 2021, March 31, 2022 December 31, 2021 As of March 31, 2022 December 31, 2021 March 31, 2022 December 31, 2021 Outstanding awards under equity incentive plans 2,186,769 1,273,879 Outstanding common stock warrants 4,252,600 4,252,600 Possible future issuances under equity incentive plans 4,697,270 4,209,935 Possible future issuances under employee stock purchase plans 1,500,000 1,500,000 Total common shares reserved for future issuance 12,636,639 11,236,414 Common Stock Activity The following table summarizes common stock activity for the three March 31, 2022 : Shares of Common Stock Balance as of January 1, 2022 35,005,640 Common stock issued as compensation to third-parties 7,649 Common stock repurchased as a result of the Stock Repurchase Plan (589,792 ) Balance as of March 31, 2022 34,423,497 Warrants On June 2, 2014, June 2, 2024, December 2020, January 2021 $93.60 June 2021 $46.25 February 2021 The Company determined that the Deerfield Warrant should be recorded as a liability and stated at fair value at each reporting period upon inception. As stated above, upon completion of the IPO, the Deerfield Warrant automatically converted into warrants to purchase the Company’s common stock. The Deerfield Warrant remains classified as a liability and is recorded at fair value at each reporting period since it can be settled in cash. Changes to the fair value of the warrant liability are recorded through the unaudited condensed statements of operations as a fair value adjustment (Note H). In connection with the APADAZ License Agreement, in October 2018, not four October 24, 2023. may December 2020, The Company determined that, since KVK qualifies as a customer under ASC 606, 815 815 606 March 31, 2022, December 31, 2021, Pre-Funded Warrants On January 12, 2021, January 2021, Warrants to Purchase Common Stock On January 12, 2021, December 2020 December 2020 fifth may may not 13 not 50% 50% not March 31, 2022, January 2021 Underwriter Warrant On January 12, 2021, February 3, 2021, March 31, 2022, January 2021 Warrant Exercise Inducement Letters and Issuance of Warrants On January 26, 2021, “January 2021 “January 2021 January 2021 January 2021 January 2021 January 2021 January 2021 The January 2021 fifth January 2021 January 2021 may may not January 2021 13 January 2021 January 2021 January 2021 not January 2021 January 2021 January 2021 January 2021 50% 50% January 2021 January 2021 January 2021 January 2021 January 2021 January 2021 not January 2021 January 2021 January 2021 March 31, 2022, January 2021 January 2021 June 2021 In accordance with the January 2021 January 2021 January 2021 June 2021 Warrant Exercise Inducement Letters and Issuance of Warrants On June 18, 2021, “June 2021 January 2021 "January 2021 “June 2021 January 2021 “June 2021 January 2021 January 2021 June 2021 June 2021 June 2021 January 2021 June 2021 June 2021 January 2021 June 2021 June 2021 $46.25 The June 2021 December 31, 2026, June 2021 June 2021 may may not June 2021 13 June 2021 June 2021 June 2021 not June 2021 June 2021 June 2021 June 2021 50% 50% June 2021 June 2021 June 2021 June 2021 June 2021 June 2021 not June 2021 June 2021 June 2021 March 31, 2022, June 2021 In accordance with the June 2021 June 2021 June 2021

Note G - Stock-based Compensati

Note G - Stock-based Compensation	3 Months Ended
	Mar. 31, 2022
Notes to Financial Statements
Share-Based Payment Arrangement [Text Block]	G. Stock-Based Compensation The Company maintains a stock-based compensation plan (the “Incentive Stock Plan”) that governs stock awards made to employees and directors prior to completion of the IPO. In November 2014, April 2015, 2014 “2014 April 2015. 2014 June 2021, 2014 2014 April 2021, January 1, 2031 2014 162 may 2014 March 31, 2022. 2014 January 1 January 1, 2016, January 1, 2031, December 31 2014 January 1, 2022, 2014 During the three March 31, 2022, 2021, Stock-based compensation expense recorded under the 2014 2014 Three months ended March 31, 2022 2021 Research and development $ 311 $ 296 General and administrative 607 379 Total stock-based compensation expense $ 918 $ 675 There was no stock-based compensation expense related to performance-based awards recognized during the three March 31, 2022, three March 31, 2021.

Note H - Fair Value of Financia

Note H - Fair Value of Financial Instruments	3 Months Ended
	Mar. 31, 2022
Notes to Financial Statements
Fair Value Disclosures [Text Block]	H. Fair Value of Financial Instruments The accounting standard for fair value measurements provides a framework for measuring fair value and requires disclosures regarding fair value measurements. Fair value is defined as the price that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date, based on the Company’s principal or, in absence of a principal, most advantageous market for the specific asset or liability. The Company uses a three three ● Level 1—Observable ● Level 2—Observable ● Level 3—Unobservable no The carrying amounts of certain financial instruments, including cash and cash equivalents, marketable securities, long-term investments and accounts payable and accrued expenses, approximate their respective fair values due to the short-term nature of such instruments. Assets and Liabilities Measured at Fair Value on a Recurring Basis The Company evaluates its financial assets and liabilities subject to fair value measurements on a recurring basis to determine the appropriate level in which to classify them for each reporting period. This determination requires significant judgments to be made. The following table summarizes the conclusions reached regarding fair value measurements as of March 31, 2022, December 31, 2021 ( Balance as of March 31, 2022 Quoted Prices in Active Markets for Identical Assets (Level 1) Significant Other Observable Inputs (Level 2) Significant Unobservable Inputs (Level 3) Deerfield Warrant liability $ 80 $ — $ — $ 80 Embedded Warrant Put Option 4 — — 4 KVK Warrant liability 5 — 5 — Total liabilities $ 89 $ — $ 5 $ 84 Trading securities: U.S. government-sponsored agency securities $ 7,335 $ — $ 7,335 $ — Corporate notes and commercial paper 1,338 — 1,338 — Certificates of deposit 481 481 — — U.S. Treasury securities 9,748 9,748 — — Total assets $ 18,902 $ 10,229 $ 8,673 $ — Balance as of December 31, 2021 Quoted Prices in Active Markets for Identical Assets (Level 1) Significant Other Observable Inputs (Level 2) Significant Unobservable Inputs (Level 3) Deerfield Warrant liability $ 288 $ — $ — $ 288 Embedded Warrant Put Option 18 — — 18 KVK Warrant liability 24 — 24 — Total liabilities $ 330 $ — $ 24 $ 306 Trading securities: U.S. government-sponsored agency securities $ 4,997 $ — $ 4,997 $ — Certificates of deposit 490 490 — — U.S. Treasury securities 9,935 9,935 — — Total assets $ 15,422 $ 10,425 $ 4,997 $ — The Company’s Deerfield Warrant liability, embedded Warrant Put Option and trading securities are measured at fair value on a recurring basis. As of March 31, 2022, December 31, 2021, March 31, 2022, December 31, 2021, three March 31, 2022, 2021, The derivative liability for the Deerfield Warrant was $80,000 and $288,000 at March 31, 2022, December 31, 2021, March 31, 2022, December 31, 2021, 10% second 2023. The Company’s KVK Warrant liability is measured at fair value on a recurring basis. As of March 31, 2022, December 31, 2021, no not not three March 31, 2022, 2021, A reconciliation of the beginning and ending balances for the derivative and warrant liability measured at fair value on a recurring basis using significant unobservable inputs (Level 3 Three months ended March 31, 2022 2021 Balance as of beginning of period $ 306 $ 255 Adjustment to fair value (222 ) 37 Balance as of end of period $ 84 $ 292

Note I - Net Loss Per Share

Note I - Net Loss Per Share	3 Months Ended
	Mar. 31, 2022
Notes to Financial Statements
Earnings Per Share [Text Block]	I. Net Loss Per Share During the three March 31, 2022, 2021, not two not two Under the two No no two two two As noted above, for the three March 31, 2022, 2021, not two no The following securities, presented on a common stock equivalent basis, have been excluded from the calculation of weighted average number of shares of common stock outstanding because their effect is anti-dilutive: Three months ended March 31, 2022 2021 Awards under equity incentive plans 2,186,769 354,869 Common stock warrants 4,252,600 9,544,693 Total securities excluded from the calculation of weighted average number of shares of common stock outstanding 6,439,369 9,899,562 A reconciliation from net loss to basic and diluted net loss attributable to common stockholders per share of common stock for the three March 31, 2022, 2021, Three months ended March 31, 2022 2021 Net loss per share of common stock: Net loss $ (1,864 ) $ (10,296 ) Less: Dividends declared or accumulated — (37,444 ) Undistributed net loss attributable to shares of common stockholders, basic and diluted $ (1,864 ) $ (47,740 ) Weighted average number of shares of common stock outstanding, basic and diluted 34,507 19,146 Basic and diluted net loss attributable to common stockholders per share of common stock $ (0.05 ) $ (2.49 )

Note J - Leases

Note J - Leases	3 Months Ended
	Mar. 31, 2022
Notes to Financial Statements
Lease Disclosure [Text Block]	J. Leases The Company has operating and finance leases for office space, laboratory facilities and various laboratory equipment, furniture and office equipment and leasehold improvements. The Company's leases have remaining lease terms of less than 1 year to approximately 4 years, some of which include options to extend the leases for up to 5 years, and some which include options to terminate the leases within 1 year. Effective June 1, 2021, one two February 2026. The components of lease expense were as follows (in thousands): Three months ended March 31, Lease Cost 2022 2021 Finance lease cost: Amortization of right-of-use assets $ 32 $ 32 Interest on lease liabilities 1 4 Total finance lease cost 33 36 Operating lease cost 91 91 Short-term lease cost 50 50 Variable lease cost 13 13 Less: sublease income (39 ) — Total lease costs $ 148 $ 190 Supplemental cash flow information related to leases was as follows (in thousands): Three months ended March 31, 2022 2021 Cash paid for amounts included in the measurement of lease liabilities: Operating cash flows from finance leases $ 1 $ 4 Financing cash flows from finance leases 10 61 Operating cash flows from operating leases 117 114 Operating cash flows from short-term leases 50 50 Operating cash flows from variable lease costs 13 13 Right-of-use assets obtained in exchange for lease liabilities: Finance leases $ — $ — Operating leases — — Supplemental balance sheet information related to leases was as follows (in thousands, except weighted average remaining lease term and weighted average discount rate): March 31, December 31, 2022 2021 Finance Leases Property and equipment, at cost $ 1,031 $ 1,031 less: accumulated depreciation and amortization (683 ) (651 ) Property and equipment, net $ 348 $ 380 Other current liabilities $ 7 $ 15 Other long-term liabilities 4 6 Total finance lease liabilities $ 11 $ 21 Operating Leases Operating lease right-of-use assets $ 1,090 $ 1,141 Total operating lease right-of-use assets $ 1,090 $ 1,141 Current portion of operating lease liabilities $ 356 $ 356 Operating lease liabilities, less current portion 1,144 1,232 Total operating lease liabilities $ 1,500 $ 1,588 Weighted Average Remaining Lease Term Finance leases (years) 2 1 Operating leases (years) 4 4 Weighted Average Discount Rate Finance leases 14.3 % 12.0 % Operating leases 7.5 % 7.5 % Maturities of lease liabilities were as follows (in thousands): Finance Operating Year Ending December 31, Leases Leases 2022 (excluding the three months ended March 31, 2022) $ 5 $ 346 2023 6 472 2024 — 484 2025 — 390 2026 — 30 Total lease payments 11 1,722 Less: future interest expense 0 (222 ) Lease liabilities $ 11 $ 1,500

Significant Accounting Policies

Significant Accounting Policies (Policies)	3 Months Ended
	Mar. 31, 2022
Accounting Policies [Abstract]
Use of Estimates, Policy [Policy Text Block]	Use of Estimates The preparation of financial statements in conformity with U.S. GAAP requires the Company to make estimates and assumptions that affect the amounts reported in the financial statements and accompanying notes. Actual results could differ from those estimates. On an ongoing basis, the Company evaluates its estimates and assumptions, including those related to revenue recognition, the useful lives of property and equipment, the recoverability of long-lived assets, the incremental borrowing rate for leases, and assumptions used for purposes of determining stock-based compensation, income taxes, the fair value of long-term investments and the fair value of the derivative and warrant liability, among others. The Company bases its estimates on historical experience and on various other assumptions that it believes to be reasonable, the results of which form the basis for making judgments about the carrying value of assets and liabilities.
Revenue from Contract with Customer [Policy Text Block]	Revenue Recognition The Company commenced recognizing revenue in accordance with the provisions of ASC 606, Revenue from Contracts with Customers 606” January 1, 2018. Arrangements with Multiple-Performance Obligations From time to time, the Company enters into arrangements for research and development, manufacturing and/or commercialization services. Such arrangements may In arrangements involving more than one not The consideration allocated to each distinct performance obligation is recognized as revenue when control of the related goods or services is transferred. Consideration associated with at-risk substantive performance milestones is recognized as revenue when it is probable that a significant reversal of the cumulative revenue recognized will not Licensing Agreements The Company enters into licensing agreements with licensees that fall under the scope of ASC 606. The terms of the Company’s licensing agreements typically include one may As part of the accounting for these agreements, the Company must develop estimates and assumptions that require judgment to determine the underlying stand-alone selling price for each performance obligation which determines how the transaction price is allocated among the performance obligations. Generally, the estimation of the stand-alone selling price may Up-front Fees: Milestone Payments: not not not may KP415 In September 2019, “KP415 KP415 KP484, KP879, KP922 KP484, KP415 KP484; KP415 KP415 In April 2021, No. 1 KP415 "KP415 KP415 KP415 KP415 KP415 March 2, 2021. May 7, 2021. KP415 KP415 KP415 Pursuant to the KP415 first KP922, no Commave also agreed to be responsible for and reimburse the Company for all of the development, commercialization and regulatory expenses incurred on the licensed products, subject to certain limitations as set forth in the KP415 In accordance with the terms of the Company’s March 20, 2012 KP484, KP879 KP1077 KP415 The KP415 606, not KP415 606, third two $10.0 KP415 The consideration allocated to the grant of the exclusive, worldwide license was $10.0 KP415 KP415 Under the KP415 first 1 may may KP415 KP415 not third 606 not not The Company is entitled to additional payments from Commave conditioned upon the achievement of specified regulatory milestones related to AZSTARYS and KP484 KP415 KP415 not not not Per the KP415 March 2021, May 2021. two 2021, first second 2021, 340 40, Contracts with Customers first second 2021. For the three March 31, 2022, 2021, KP415 March 31, 2022, December 31, 2021. Consulting Arrangements The Company enters into consulting arrangements with third 606. may third Corium Consulting Agreement In July 2020, KP415 Under the Corium Consulting Agreement, the Company is entitled to receive payments from Corium of up to $15.6 million, $13.6 million of which was earned in monthly installments through March 31, 2022 first 2022 March 31, 2022. The Corium Consulting Agreement is within the scope of ASC 606, not 606, third third not not not The Company determined that the performance of consulting services, including reimbursement of third third 606 March 31, 2022, third For the three March 31, 2022, 2021, March 31, 2022, December 31, 2021, Other Consulting Arrangements The Company recognized no revenue under other consulting arrangements for the three March 31, 2022. three March 31, 2021, March 31, 2022, December 31, 2021.
Receivable [Policy Text Block]	Accounts and Other Receivables Accounts and other receivables consist of receivables under the KP415 KP415 third March 31, 2022, KP415 December 31, 2021, KP415 March 31, 2022, December 31, 2021, no
New Accounting Pronouncements, Policy [Policy Text Block]	Application of New or Revised Accounting Standards—Adopted From time to time, the Financial Accounting Standards Board (the “FASB”) or other standard-setting bodies issue accounting standards that are adopted by the Company as of the specified effective date. In August 2020, 2020 06, Debt Debt with Conversion and Other Options (Subtopic 470 20 and Derivatives and Hedging Contracts in Entity s Own Equity (Subtopic 815 40 Accounting for Convertible Instruments and Contracts in an Entity s Own Equity 2020 06” December 15, 2021, 2020 06 not In May 2021, 2021 04, Earnings Per Share (Topic 260 470 50 718 815 40 2021 04” December 15, 2021, 2021 04 not

Note F - Common Stock and War_2

Note F - Common Stock and Warrants (Tables)	3 Months Ended
	Mar. 31, 2022
Notes Tables
Schedule of Authorized Shares of Common Stock Reserved for Future Issuance [Table Text Block]	March 31, 2022 December 31, 2021 Outstanding awards under equity incentive plans 2,186,769 1,273,879 Outstanding common stock warrants 4,252,600 4,252,600 Possible future issuances under equity incentive plans 4,697,270 4,209,935 Possible future issuances under employee stock purchase plans 1,500,000 1,500,000 Total common shares reserved for future issuance 12,636,639 11,236,414
Schedule of Common Stock Outstanding Roll Forward [Table Text Block]	Shares of Common Stock Balance as of January 1, 2022 35,005,640 Common stock issued as compensation to third-parties 7,649 Common stock repurchased as a result of the Stock Repurchase Plan (589,792 ) Balance as of March 31, 2022 34,423,497

Note G - Stock-based Compensa_2

Note G - Stock-based Compensation (Tables)	3 Months Ended
	Mar. 31, 2022
Notes Tables
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]	Three months ended March 31, 2022 2021 Research and development $ 311 $ 296 General and administrative 607 379 Total stock-based compensation expense $ 918 $ 675

Note H - Fair Value of Financ_2

Note H - Fair Value of Financial Instruments (Tables)	3 Months Ended
	Mar. 31, 2022
Notes Tables
Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block]	Balance as of March 31, 2022 Quoted Prices in Active Markets for Identical Assets (Level 1) Significant Other Observable Inputs (Level 2) Significant Unobservable Inputs (Level 3) Deerfield Warrant liability $ 80 $ — $ — $ 80 Embedded Warrant Put Option 4 — — 4 KVK Warrant liability 5 — 5 — Total liabilities $ 89 $ — $ 5 $ 84 Trading securities: U.S. government-sponsored agency securities $ 7,335 $ — $ 7,335 $ — Corporate notes and commercial paper 1,338 — 1,338 — Certificates of deposit 481 481 — — U.S. Treasury securities 9,748 9,748 — — Total assets $ 18,902 $ 10,229 $ 8,673 $ — Balance as of December 31, 2021 Quoted Prices in Active Markets for Identical Assets (Level 1) Significant Other Observable Inputs (Level 2) Significant Unobservable Inputs (Level 3) Deerfield Warrant liability $ 288 $ — $ — $ 288 Embedded Warrant Put Option 18 — — 18 KVK Warrant liability 24 — 24 — Total liabilities $ 330 $ — $ 24 $ 306 Trading securities: U.S. government-sponsored agency securities $ 4,997 $ — $ 4,997 $ — Certificates of deposit 490 490 — — U.S. Treasury securities 9,935 9,935 — — Total assets $ 15,422 $ 10,425 $ 4,997 $ —
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block]	Three months ended March 31, 2022 2021 Balance as of beginning of period $ 306 $ 255 Adjustment to fair value (222 ) 37 Balance as of end of period $ 84 $ 292

Note I - Net Loss Per Share (Ta

Note I - Net Loss Per Share (Tables)	3 Months Ended
	Mar. 31, 2022
Notes Tables
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]	Three months ended March 31, 2022 2021 Awards under equity incentive plans 2,186,769 354,869 Common stock warrants 4,252,600 9,544,693 Total securities excluded from the calculation of weighted average number of shares of common stock outstanding 6,439,369 9,899,562
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]	Three months ended March 31, 2022 2021 Net loss per share of common stock: Net loss $ (1,864 ) $ (10,296 ) Less: Dividends declared or accumulated — (37,444 ) Undistributed net loss attributable to shares of common stockholders, basic and diluted $ (1,864 ) $ (47,740 ) Weighted average number of shares of common stock outstanding, basic and diluted 34,507 19,146 Basic and diluted net loss attributable to common stockholders per share of common stock $ (0.05 ) $ (2.49 )

Note J - Leases (Tables)

Note J - Leases (Tables)	3 Months Ended
	Mar. 31, 2022
Notes Tables
Lease, Cost [Table Text Block]	Three months ended March 31, Lease Cost 2022 2021 Finance lease cost: Amortization of right-of-use assets $ 32 $ 32 Interest on lease liabilities 1 4 Total finance lease cost 33 36 Operating lease cost 91 91 Short-term lease cost 50 50 Variable lease cost 13 13 Less: sublease income (39 ) — Total lease costs $ 148 $ 190
Schedule of Leases Cash Flow Information [Table Text Block]	Three months ended March 31, 2022 2021 Cash paid for amounts included in the measurement of lease liabilities: Operating cash flows from finance leases $ 1 $ 4 Financing cash flows from finance leases 10 61 Operating cash flows from operating leases 117 114 Operating cash flows from short-term leases 50 50 Operating cash flows from variable lease costs 13 13 Right-of-use assets obtained in exchange for lease liabilities: Finance leases $ — $ — Operating leases — —
Schedule of Leases Balance Sheet Information [Table Text Block]	March 31, December 31, 2022 2021 Finance Leases Property and equipment, at cost $ 1,031 $ 1,031 less: accumulated depreciation and amortization (683 ) (651 ) Property and equipment, net $ 348 $ 380 Other current liabilities $ 7 $ 15 Other long-term liabilities 4 6 Total finance lease liabilities $ 11 $ 21 Operating Leases Operating lease right-of-use assets $ 1,090 $ 1,141 Total operating lease right-of-use assets $ 1,090 $ 1,141 Current portion of operating lease liabilities $ 356 $ 356 Operating lease liabilities, less current portion 1,144 1,232 Total operating lease liabilities $ 1,500 $ 1,588 Weighted Average Remaining Lease Term Finance leases (years) 2 1 Operating leases (years) 4 4 Weighted Average Discount Rate Finance leases 14.3 % 12.0 % Operating leases 7.5 % 7.5 %
Operating and Finance Lease, Liability, Maturity [Table Text Block]	Finance Operating Year Ending December 31, Leases Leases 2022 (excluding the three months ended March 31, 2022) $ 5 $ 346 2023 6 472 2024 — 484 2025 — 390 2026 — 30 Total lease payments 11 1,722 Less: future interest expense 0 (222 ) Lease liabilities $ 11 $ 1,500

Note A - Description of Busin_2

Note A - Description of Business and Basis of Presentation (Details Textual) - USD ($) $ / shares in Units, $ in Thousands	Jul. 12, 2021	Feb. 01, 2021	Jan. 12, 2021	Jan. 08, 2021	Mar. 31, 2022	Dec. 31, 2021	Dec. 20, 2021	Jul. 02, 2021	Feb. 03, 2021
Sale of Stock, Authorized Amount	$ 350,000
Stock Repurchase Program, Authorized Amount							$ 50,000
Treasury Stock, Value, Total					$ 7,536	$ 2,814
Share Repurchase Program [Member]
Treasury Stock, Shares, Total (in shares)					909,953
Treasury Stock, Value, Total					$ 7,500
Roth Capital Partners, LLC [Member] | Pre-funded Warrants [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)			926,844	926,844
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)			$ 0.0001
Roth Capital Partners, LLC [Member] | Public Offering Warrants [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)			12,078,361	7,692,307
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)			$ 6.50	$ 6.50
Class of Warrant or Right, Offering Price, Per Related Warrant (in dollars per share)				$ 0.0001
Roth Capital Partners, LLC [Member] | Underwriter Warrants [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)			806,932	754,035					18,702
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)			$ 8.125
Over Allotment Options, Number of Shares for Warrants (in shares)				1,153,846
Underwriting Agreement [Member] | Roth Capital Partners, LLC [Member]
Stock Issued During Period, Shares, New Issues (in shares)				6,765,463
Shares and Warrants Issued, Price Per Share (in dollars per share)				$ 6.50
Shares Issued, Price Per Share (in dollars per share)				$ 6.4999
Proceeds from Issuance or Sale of Equity, Total			$ 52,400
Over-Allotment Option [Member] | Roth Capital Partners, LLC [Member]
Stock Issued During Period, Shares, New Issues (in shares)		374,035
Purchase Agreement Optional Period to Shares (Day)				45 days
Purchase Agreement, Maximum, Additional Shares Available for Purchase During the Optional Period (in shares)				1,153,846
ATM Agreement Sales [Member] | JMP and RBCCM [Member]
Stock Issued During Period, Shares, New Issues (in shares)					0
Equity Distribution Agreement, Maximum Aggregate Offering Price								$ 75,000
Equity Distribution Agreement, Commission Fee, Percentage of Gross Sales								3.00%
Stock Issued During Period, Value, New Issues	$ 75,000

Note B - Summary of Significa_2

Note B - Summary of Significant Accounting Policies (Details Textual) - USD ($) $ in Thousands	May 07, 2021	Apr. 08, 2021	Mar. 02, 2021	Sep. 03, 2019	Mar. 20, 2012	Mar. 31, 2022	Mar. 31, 2021	Dec. 31, 2021	Dec. 31, 2020	Jul. 31, 2020
Revenue from Contract with Customer, Including Assessed Tax						$ 3,965	$ 12,117
Consulting Services [Member]
Revenue from Contract with Customer, Including Assessed Tax						0	500
Deferred Revenue, Total						0			$ 0
Accounts Receivable, after Allowance for Credit Loss, Current, Total						100		$ 100
GPC Member | License [Member]
Revenue from Contract with Customer, Including Assessed Tax	$ 10,000	$ 10,000	$ 10,000	$ 10,000
Revenue Recognition, Milestone Method, Revenue to be Recognized		$ 10,000		63,000
Revenue Recognition, Milestone Method, Additional Revenue to be Recognized	$ 590,000			$ 420,000
Contract with Customer, Liability, Revenue Recognized							10,000
Deferred Revenue, Total						0		0
Accounts Receivable, after Allowance for Credit Loss, Current, Total						100		100
Aquestive Therapeutics [Member] | License [Member]
Revenue from Contract with Customer, Including Assessed Tax						100	10,000
Royalty Revenue, Percent					10.00%
Royalty Expense							1,000
Corium, Inc [Member]
Accounts Receivable, after Allowance for Credit Loss, Current, Total						3,000		1,200
Corium, Inc [Member] | Consulting Services [Member]
Revenue from Contract with Customer, Including Assessed Tax						3,500	$ 1,600
Deferred Revenue, Total						$ 0		$ 400
Consulting Agreement, Maximum Amount to be Received										$ 15,600
Contract with Customer, Asset, after Allowance for Credit Loss, Total										13,600
Consulting Agreement, Conditional Milestone Achievement to be Received										$ 2,000

Note C - Debt Obligations (Deta

Note C - Debt Obligations (Details Textual) - USD ($)	Feb. 08, 2021	Jan. 12, 2021	Jan. 01, 2021	Apr. 23, 2020	Jan. 13, 2020	Dec. 18, 2019	Feb. 09, 2016	Jun. 02, 2014	Jun. 30, 2018	Mar. 31, 2022	Mar. 31, 2021	Sep. 30, 2020	Dec. 31, 2020	Dec. 31, 2021	Jun. 18, 2021	Jan. 26, 2021	Dec. 31, 2019	Sep. 30, 2019	Sep. 02, 2019	Jun. 30, 2016
Convertible Notes Payable, Total										$ 0				$ 0
Debt Conversion, Converted Instrument, Shares Issued (in shares)												1,777,437
Interest Paid, Excluding Capitalized Interest, Operating Activities										$ 5,000	$ 199,000
Debt Instrument, Convertible, Minimum Conversion Price (in dollars per share)																	$ 9.328
Conversion from Deerfield Convertible Note to Common Stock [Member]
Debt Conversion, Original Debt, Amount									$ 3,300,000
Debt Conversion, Accrued Interest									$ 200,000
Debt Conversion, Converted Instrument, Shares Issued (in shares)									37,410
Conversion of December 2019 Notes into Common Stock [Member]
Debt Conversion, Original Debt, Amount												$ 17,100,000
December 2020 Exchange Agreement [Member]
Debt Conversion, Original Debt, Amount		$ 31,500,000
Debt Conversion, Converted Instrument, Shares Issued (in shares)		31,476.98412
Debt Conversion, Converted Instrument, Warrants or Options Issued (in shares)		3,632,019
Deerfield Convertible Notes [Member]
Debt Instrument, Convertible, Conversion Price (in dollars per share)																	93.60
2021 Notes [Member]
Debt Instrument, Convertible, Conversion Price (in dollars per share)							$ 17.11						$ 273.76
Debt Conversion, Original Debt, Amount							$ 1,000						$ 1,000
Debt Conversion, Converted Instrument, Shares Issued (in shares)							58.4454						3.6528
Debt Instrument, Interest Rate, Stated Percentage							5.50%
Debt Instrument, Face Amount							$ 86,300,000
Proceeds from Debt, Net of Issuance Costs							82,800,000
Repayments of Long-term Debt, Total							18,600,000
Debt Instrument, Sinking Fund Payment							$ 0
Debt Instrument Repurchase Price Equal to Percentage of Principal Amount							100.00%
Debt Instrument, Cancellation of Debt, Amount					$ 3,000,000	$ 71,400,000
Interest Paid, Excluding Capitalized Interest, Operating Activities					$ 37,000	$ 700,000
Debt Instrument, Percentage of Accrued Interest Paid						50.00%
The 2019 Notes [Member]
Debt Instrument, Convertible, Conversion Price (in dollars per share)					$ 5.85	$ 17.11							$ 93.60				273.76
Debt Instrument, Interest Rate, Stated Percentage						6.75%
Debt Instrument, Face Amount						$ 71,400,000
Debt Instrument, Percentage of Accrued Interest Paid					50.00%
Debt Instrument, Convertible, Minimum Conversion Price (in dollars per share)					$ 0.583												$ 0.38
Debt Instrument, Convertible, Conversion Restriction Percentage of Common Stock						4.985%
Beneficial Ownership, Cap Limit, Percentage						19.985%
Debt Instrument, Convertible, Floor Price (in dollars per share)													$ 9.328
January 2020 Note [Member]
Debt Instrument, Face Amount					$ 3,000,000
The December 2020 Exchange Agreement [Member]
Repayments of Debt			$ 30,300,000
The December 2019 and January 2020 Notes [Member]
Long-term Debt, Gross													$ 60,800,000
Deerfield Facility Agreement [Member]
Long-term Debt, Gross													7,500,000
The Facility Notes [Member]
Debt Instrument, Interest Rate, Stated Percentage		6.75%
Repayments of Long-term Debt, Total		$ 30,300,000
Long-term Debt, Total		$ 7,600,000											$ 69,400,000
Paycheck Protection Program CARES Act [Member]
Proceeds from Issuance of Long-term Debt, Total				$ 800,000
Deerfield Facility Agreement [Member]
Line of Credit Facility, Maximum Borrowing Capacity								$ 60,000,000
Line of Credit Facility, Interest Rate at Period End								9.75%												6.75%
Debt Instrument, Interest Rate, Stated Percentage																		6.75%	9.75%
Convertible Notes Payable, Current											$ 7,000,000
Debt Covenant, Debt Financing Restriction								$ 750,000
Repayments of Long-term Debt, Total	$ 8,000,000
Debt Instrument, Convertible, Minimum Conversion Price (in dollars per share)						$ 0.60
Conversion of Stock, Maximum Shares Issued (in shares)						28,439,015
Debt Instrument, Convertible, Optional Conversion Feature, Exchange Price (in dollars per share)													$ 9.60
Debt Instrument, Convertible Optional Conversion Feature Shares Issuable Upon Exchange (in shares)													1,777,437
Deerfield Facility Agreement [Member] | Deerfield Warrant [Member]
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)								$ 0.78
Deerfield Facility Agreement [Member] | Deerfield Warrant [Member] | IPO [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)								1,923,077
Deerfield Facility Agreement [Member] | Series D Redeemable Convertible Preferred Stock [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)								14,423,076
Deerfield Facility Agreement [Member] | Term Notes [Member]
Proceeds from Secured Notes Payable								$ 15,000,000
Deerfield Facility Agreement [Member] | Deerfield Convertible Notes [Member]
Proceeds from Secured Notes Payable								$ 10,000,000
Debt Instrument, Convertible, Conversion Price (in dollars per share)								$ 5.85					$ 93.60
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)													120,192
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)								$ 5.85					$ 93.60		$ 38.34	$ 46.25

Note D - Commitments and Cont_2

Note D - Commitments and Contingencies (Details Textual) - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021
Loss Contingency Accrual, Ending Balance	$ 0	$ 0

Note E - Preferred Stock and _2

Note E - Preferred Stock and Warrants (Details Textual) - USD ($) $ / shares in Units, $ in Millions	Jan. 12, 2021	Jun. 30, 2021	Mar. 31, 2021	Sep. 30, 2020	Mar. 31, 2022	Dec. 31, 2021
Preferred Stock, Shares Authorized (in shares)					10,000,000	10,000,000
Preferred Stock, Shares Issued, Total (in shares)					0	0
Preferred Stock, Shares Outstanding, Ending Balance (in shares)					0	0
Debt Conversion, Converted Instrument, Shares Issued (in shares)				1,777,437
Conversion of Series B-2 Preferred Stock into Common Stock [Member]
Conversion of Stock, Shares Issued (in shares)			4,842,699
The Facility Notes [Member]
Repayments of Long-term Debt, Total	$ 30.3
December 2020 Exchange Agreement [Member]
Debt Conversion, Converted Instrument, Shares Issued (in shares)	31,476.98412
Debt Conversion, Converted Instrument, Warrants or Options Issued (in shares)	3,632,019
Debt Conversion, Original Debt, Amount	$ 31.5
Series A Preferred Stock [Member]
Preferred Stock, Shares Authorized (in shares)		9,578
Series B-1 Convertible Preferred Stock [Member]
Preferred Stock, Shares Issued, Total (in shares)		1,576
Series B-2 Convertible Preferred Stock [Member]
Preferred Stock, Shares Authorized, Elimated (in shares)		31,480
Preferred Stock, Convertible, Shares Issuable (in shares)	4,842,690
Preferred Stock, Convertible, Conversion Price (in dollars per share)	$ 6.4999

Note F - Common Stock and War_3

Note F - Common Stock and Warrants (Details Textual) - USD ($) $ / shares in Units, $ in Thousands	Jan. 26, 2021	Jan. 12, 2021	Oct. 25, 2018	Jun. 02, 2014	Jan. 31, 2021	Mar. 31, 2022	Mar. 31, 2021	Jun. 18, 2021	Dec. 31, 2021	Feb. 03, 2021	Jan. 08, 2021	Dec. 31, 2020
Common Stock, Shares Authorized (in shares)						250,000,000			250,000,000
Common Stock, Shares, Issued (in shares)						35,333,450			35,325,801
Common Stock, Shares, Outstanding, Ending Balance (in shares)						34,423,497			35,005,640
Proceeds from Warrant Exercises						$ 0	$ 25,593
Preferred Stock Dividends and Other Adjustments, Total						$ 0	$ 37,444
Other Noncurrent Assets [Member]
Contract with Customer, Asset, after Allowance for Credit Loss, Total									$ 400
Deerfield Warrant [Member]
Class of Warrant or Right Issued (in shares)				14,423,076
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)	$ 46.25							$ 38.34				$ 93.60
Deerfield Warrant [Member] | Common Stock [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)				1,923,077								120,192
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)	$ 46.25			$ 5.85				$ 38.34				$ 93.60
Warrant Issued to KVK [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)			500,000									31,250
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)			$ 2.30									$ 36.80
Class of Warrant or Right, Additional Shares Exercisable for Each Milestones (in shares)			125,000
Pre-funded Warrants [Member] | Roth Capital Partners, LLC [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)		926,844									926,844
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)		$ 0.0001
Stock Issued During Period, Shares, Warrant Exercises (in shares)					926,841
Proceeds from Warrant Exercises					$ 72,000
Public Offering Warrants [Member] | Roth Capital Partners, LLC [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)		12,078,361									7,692,307
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)		$ 6.50									$ 6.50
Stock Issued During Period, Shares, Warrant Exercises (in shares)						3,030,881
Proceeds from Warrant Exercises						$ 16,900
Warrants and Rights Outstanding, Term (Year)		5 years
Maximum Percent of Common Stock Ownership Allowed Per Holder Upon Warrant Exercise		4.99%
Class of Warrants or Right, Exercised During Period (in shares)						3,461,858
Underwriter Warrants [Member] | Roth Capital Partners, LLC [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)		806,932								18,702	754,035
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)		$ 8.125
Stock Issued During Period, Shares, Warrant Exercises (in shares)						400,000
Proceeds from Warrant Exercises						$ 3,300
Class of Warrants or Right, Exercised During Period (in shares)						400,000
Over Allotment Options, Percentage of Common Stock Outstanding for Warrants		5.00%
Existing Warrants [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)	6,620,358
Proceeds from Warrant Exercises	$ 44,000
Placement Agent Fee, Percentage	6.00%
January 2021 Inducement Warrants [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)	7,944,430							6,117,509
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)	$ 6.36
Stock Issued During Period, Shares, Warrant Exercises (in shares)						1,676,921
Proceeds from Warrant Exercises						$ 10,700		$ 39,100
Warrants and Rights Outstanding, Term (Year)	5 years
Maximum Percent of Common Stock Ownership Allowed Per Holder Upon Warrant Exercise	4.99%
Class of Warrants or Right, Exercised During Period (in shares)						1,676,921
Warrants Issued Upon Exchange, Percentage of Shares Issued Upon Exercise	120.00%
Class of Warrant, Purchase Price Per Warrant (in dollars per share)	$ 0.125
Placement Agent Fee, Percentage								6.00%
Maximum Percent of Common Stock Ownership Allowed Per Holder After Warrant Exercise Upon Holders Selection	9.99%
Preferred Stock Dividends and Other Adjustments, Total						$ 37,400
June 2021 Inducement Warrants [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)								1,529,379
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)								$ 16.50
Maximum Percent of Common Stock Ownership Allowed Per Holder Upon Warrant Exercise								4.99%
Class of Warrants or Right, Exercised During Period (in shares)						0
Warrants Issued Upon Exchange, Percentage of Shares Issued Upon Exercise								25.00%
Class of Warrant, Purchase Price Per Warrant (in dollars per share)								$ 0.125
Maximum Percent of Common Stock Ownership Allowed Per Holder After Warrant Exercise Upon Holders Selection								9.99%
Preferred Stock Dividends and Other Adjustments, Total						$ 16,900

Note F - Common Stock and War_4

Note F - Common Stock and Warrants - Reserved Authorized Shares of Common Stock for Future Issuance (Details) - shares	Mar. 31, 2022	Dec. 31, 2021
Common shares reserved for future issuance (in shares)	12,636,639	11,236,414
Warrant [Member]
Common shares reserved for future issuance (in shares)	4,252,600	4,252,600
Share-Based Payment Arrangement [Member]
Common shares reserved for future issuance (in shares)	2,186,769	1,273,879
Possible Future Issuances Under Equity Incentive Plans [Member]
Common shares reserved for future issuance (in shares)	4,697,270	4,209,935
Possible Future Issuances Under Employee Stock Purchase Plans [Member]
Common shares reserved for future issuance (in shares)	1,500,000	1,500,000

Note F - Common Stock and War_5

Note F - Common Stock and Warrants - Common Stock Activity (Details)	3 Months Ended
	Mar. 31, 2022USD ($)shares
Balance (in shares)	35,005,640
Common stock issued as compensation to third-parties (in shares)	7,649
Common stock repurchased as a result of the Stock Repurchase Plan | $	$ (589,792)
Balance (in shares)	34,423,497

Note G - Stock-based Compensa_3

Note G - Stock-based Compensation (Details Textual) - USD ($) $ in Thousands	Jan. 01, 2022	Jun. 30, 2021	Mar. 31, 2022	Mar. 31, 2021
Share-Based Payment Arrangement, Expense			$ 918	$ 675
Performance Shares [Member]
Share-Based Payment Arrangement, Expense			$ 0	$ 400
2014 Equity Incentive Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Number of Additional Shares Authorized (in shares)		4,900,000
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized (in shares)			5,489,660
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Reserved for Issuance, Incremental Percentage of Capital Stock Outstanding		4.00%
Increase in Common Stock Reserved for Issuance (in shares)	1,400,225
Stock Issued During Period, Shares, Restricted Stock Award, Net of Forfeitures, Total (in shares)			0

Note G - Stock-based Compensa_4

Note G - Stock-based Compensation - Stock-based Compensation Expense (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Stock based compensation expense	$ 918	$ 675
Research and Development Expense [Member]
Stock based compensation expense	311	296
General and Administrative Expense [Member]
Stock based compensation expense	$ 607	$ 379

Note H - Fair Value of Financ_3

Note H - Fair Value of Financial Instruments (Details Textual)	3 Months Ended
	Mar. 31, 2022USD ($)	Dec. 31, 2021USD ($)
Deerfield Warrant Liability [Member]
Liabilities, Fair Value Disclosure, Total	$ 80,000	$ 288,000
Liabilities, Fair Value Disclosure, Increase from Ten Percent Increase in Enterprise Value	16,000
Liabilities, Fair Value Disclosure, Estimated Amount of Weighted-average Probability of Liquidity Event	30,000,000
Liabilities, Fair Value Disclosure, Estimated Amount of Weighted-average Probability of Fundamental Change	$ 390,000,000
Deerfield Warrant Liability [Member] | Weighted Average Probability of Liquidity Event [Member]
Derivative Liability, Measurement Input	0.23
Deerfield Warrant Liability [Member] | Weighted Average Probability of Fundamental Change [Member]
Derivative Liability, Measurement Input	33
Embedded Put Option [Member]
Liabilities, Fair Value Disclosure, Total	$ 4,000	$ 18,000
Liabilities, Fair Value Disclosure, Increase from Ten Percent Increase in Enterprise Value	$ 1,000

Note H - Fair Value of Financ_4

Note H - Fair Value of Financial Instruments - Assets and Liabilities Measured at Fair Value on Recurring Basis (Details) - USD ($)	Mar. 31, 2022	Dec. 31, 2021
Fair Value, Recurring [Member]
Total assets	$ 18,902,000	$ 15,422,000
Fair Value, Recurring [Member] | US Government Agencies Debt Securities [Member]
Total assets	7,335,000	4,997,000
Fair Value, Recurring [Member] | Corporate Debt Securities [Member]
Total assets	1,338,000
Fair Value, Recurring [Member] | Certificates of Deposit [Member]
Total assets	481,000	490,000
Fair Value, Recurring [Member] | US Treasury Securities [Member]
Total assets	9,748,000	9,935,000
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 1 [Member]
Total assets	10,229,000	10,425,000
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 1 [Member] | US Government Agencies Debt Securities [Member]
Total assets	0	0
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 1 [Member] | Corporate Debt Securities [Member]
Total assets	0
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 1 [Member] | Certificates of Deposit [Member]
Total assets	481,000	490,000
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 1 [Member] | US Treasury Securities [Member]
Total assets	9,748,000	9,935,000
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 2 [Member]
Total assets	8,673,000	4,997,000
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 2 [Member] | US Government Agencies Debt Securities [Member]
Total assets	7,335,000	4,997,000
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 2 [Member] | Corporate Debt Securities [Member]
Total assets	1,338,000
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 2 [Member] | Certificates of Deposit [Member]
Total assets	0	0
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 2 [Member] | US Treasury Securities [Member]
Total assets	0	0
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 3 [Member]
Total assets	0	0
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 3 [Member] | US Government Agencies Debt Securities [Member]
Total assets	0	0
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 3 [Member] | Corporate Debt Securities [Member]
Total assets	0
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 3 [Member] | Certificates of Deposit [Member]
Total assets	0	0
Fair Value, Recurring [Member] | Fair Value, Inputs, Level 3 [Member] | US Treasury Securities [Member]
Total assets	0	0
Deerfield Warrant Liability [Member]
Financial liabilities measured at fair value on recurring basis	80,000	288,000
Deerfield Warrant Liability [Member] | Fair Value, Recurring [Member]
Financial liabilities measured at fair value on recurring basis	80,000	288,000
Deerfield Warrant Liability [Member] | Fair Value, Recurring [Member] | Fair Value, Inputs, Level 1 [Member]
Financial liabilities measured at fair value on recurring basis	0	0
Deerfield Warrant Liability [Member] | Fair Value, Recurring [Member] | Fair Value, Inputs, Level 2 [Member]
Financial liabilities measured at fair value on recurring basis	0	0
Deerfield Warrant Liability [Member] | Fair Value, Recurring [Member] | Fair Value, Inputs, Level 3 [Member]
Financial liabilities measured at fair value on recurring basis	80,000	288,000
Embedded Put Option [Member]
Financial liabilities measured at fair value on recurring basis	4,000	18,000
Embedded Put Option [Member] | Fair Value, Recurring [Member]
Financial liabilities measured at fair value on recurring basis	4,000	18,000
Embedded Put Option [Member] | Fair Value, Recurring [Member] | Fair Value, Inputs, Level 1 [Member]
Financial liabilities measured at fair value on recurring basis	0	0
Embedded Put Option [Member] | Fair Value, Recurring [Member] | Fair Value, Inputs, Level 2 [Member]
Financial liabilities measured at fair value on recurring basis	0	0
Embedded Put Option [Member] | Fair Value, Recurring [Member] | Fair Value, Inputs, Level 3 [Member]
Financial liabilities measured at fair value on recurring basis	4,000	18,000
KVK Warrant Liability [Member] | Fair Value, Recurring [Member]
Financial liabilities measured at fair value on recurring basis	5,000	24,000
KVK Warrant Liability [Member] | Fair Value, Recurring [Member] | Fair Value, Inputs, Level 1 [Member]
Financial liabilities measured at fair value on recurring basis	0	0
KVK Warrant Liability [Member] | Fair Value, Recurring [Member] | Fair Value, Inputs, Level 2 [Member]
Financial liabilities measured at fair value on recurring basis	5,000	24,000
KVK Warrant Liability [Member] | Fair Value, Recurring [Member] | Fair Value, Inputs, Level 3 [Member]
Financial liabilities measured at fair value on recurring basis	0	0
Optional Exchange Principal Amount Conversion Feature [Member[ | Fair Value, Recurring [Member]
Financial liabilities measured at fair value on recurring basis	89,000	330,000
Optional Exchange Principal Amount Conversion Feature [Member[ | Fair Value, Recurring [Member] | Fair Value, Inputs, Level 1 [Member]
Financial liabilities measured at fair value on recurring basis	0	0
Optional Exchange Principal Amount Conversion Feature [Member[ | Fair Value, Recurring [Member] | Fair Value, Inputs, Level 2 [Member]
Financial liabilities measured at fair value on recurring basis	5,000	24,000
Optional Exchange Principal Amount Conversion Feature [Member[ | Fair Value, Recurring [Member] | Fair Value, Inputs, Level 3 [Member]
Financial liabilities measured at fair value on recurring basis	$ 84,000	$ 306,000

Note H - Fair Value of Financ_5

Note H - Fair Value of Financial Instruments - Reconciliation of Beginning and Ending Balances for Derivative and Warrant Liability Measured at Fair Value on Recurring Basis (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Balance as of beginning of period	$ 306	$ 255
Adjustment to fair value	(222)	37
Balance as of end of period	$ 84	$ 292

Note I - Net Loss Per Share - A

Note I - Net Loss Per Share - Anti-dilutive Securities (Details) - shares	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Antidilutive securities (in shares)	6,439,369	9,899,562
Share-Based Payment Arrangement [Member]
Antidilutive securities (in shares)	2,186,769	354,869
Warrants to Purchase Common Stock [Member]
Antidilutive securities (in shares)	4,252,600	9,544,693

Note I - Net Loss Per Share - E

Note I - Net Loss Per Share - Earnings Per Share (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Net loss	$ (1,864)	$ (10,296)
Less: Dividends declared or accumulated	0	(37,444)
Undistributed net loss attributable to shares of common stockholders, basic and diluted	$ (1,864)	$ (47,740)
Weighted average number of shares of common stock outstanding, basic and diluted (in shares)	34,506,597	19,146,270
Basic and diluted net loss attributable to common stockholders per share of common stock (in dollars per share)	$ (0.05)	$ (2.49)

Note J - Leases (Details Textua

Note J - Leases (Details Textual)	3 Months Ended
	Mar. 31, 2022
Lessee, Lease, Option to Extend, Maximum Term (Year)	5 years
Lessee, Lease, Option to Terminate, Term (Year)	1 year
Minimum [Member]
Lessee, Lease, Remaining Term of Contract (Year)	1 year
Maximum [Member]
Lessee, Lease, Remaining Term of Contract (Year)	4 years

Note J - Leases - Lease Cost (D

Note J - Leases - Lease Cost (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Amortization of right-of-use assets	$ 32	$ 32
Interest on lease liabilities	1	4
Total finance lease cost	33	36
Operating lease cost	91	91
Short-term lease cost	50	50
Variable lease cost	13	13
Less: sublease income	(39)	0
Total lease costs	$ 148	$ 190

Note J - Leases - Supplement Ca

Note J - Leases - Supplement Cash Flow Information Related to Leases (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Operating cash flows from finance leases	$ 1	$ 4
Financing cash flows from finance leases	10	61
Operating cash flows from operating leases	117	114
Operating cash flows from short-term leases	50	50
Operating cash flows from variable lease costs	13	13
Finance leases	0	0
Operating leases	$ 0	$ 0

Note J - Leases - Supplement Ba

Note J - Leases - Supplement Balance Sheet Information Related to Lease (Details) - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021
Lease liabilities, finance leases	$ 11	$ 21
Operating lease right-of-use assets	1,090	1,141
Total operating lease right-of-use assets	1,090	1,141
Current portion of operating lease liabilities	356	356
Operating lease liabilities, less current portion	1,144	1,232
Total operating lease liabilities	$ 1,500	$ 1,588
Finance leases (years) (Year)	2 years	1 year
Operating leases (years) (Year)	4 years	4 years
Finance leases	14.30%	12.00%
Operating leases	7.50%	7.50%
Property and Equipment, At Cost [Member]
Property and equipment, at cost	$ 1,031	$ 1,031
Accumulated Depreciation and Amortization [Member]
less: accumulated depreciation and amortization	(683)	(651)
Property and Equipment, Net [Member]
Property and equipment, net	348	380
Other Current Liabilities [Member]
Other current liabilities	7	15
Other Noncurrent Liabilities [Member]
Other long-term liabilities	4	6
Operating Lease Right-of-Use Assets [Member]
Operating lease right-of-use assets	1,090	1,141
Total operating lease right-of-use assets	1,090	1,141
Current Portion of Operating Lease Liabilities [Member]
Current portion of operating lease liabilities	356	356
Operating Lease Liabilities, Less Current Portion [Member]
Operating lease liabilities, less current portion	$ 1,144	$ 1,232

Note J - Leases - Maturities of

Note J - Leases - Maturities of lease Liabilities (Details) - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021
2022 (excluding the three months ended March 31, 2021), finance leases	$ 5
2022 (excluding the three months ended March 31, 2021), operating leases	346
2023, finance leases	6
2023, operating leases	472
2024, finance leases	0
2024, operating leases	484
2025, finance leases	0
2025, operating leases	390
2026, finance leases	0
2026, operating leases	30
Total lease payments, finance leases	11
Total lease payments, operating leases	1,722
Less: future interest expense, finance leases	0
Less: future interest expense, operating leases	(222)
Lease liabilities, finance leases	11	$ 21
Lease liabilities, operating leases	$ 1,500	$ 1,588