Chinook Therapeutics (KDNY) 8-K Aduro Biotech Presents Preliminary Results from Ongoing Phase 1 Trials of STING agonist

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Aduro Biotech Presents Preliminary Results from Ongoing Phase 1 Trials of STING agonist

ADU-S100 (MIW815) in Patients with Advanced Solid Tumors or Lymphomas

- Data presented at Society for Immunotherapy of Cancer 33^rd Annual Meeting (SITC 2018) demonstrateADU-S100 (MIW815) is well-tolerated with no dose-limiting toxicities reported

- Preliminary signs of clinical and biomarker activity observed in patients with advanced cancers, including those pretreated with checkpoint inhibitor therapy

- Single agent data supports further evaluation ofADU-S100 in combination with checkpoint inhibitor therapies

- ADU-S100 is currently in a combination trial with investigationalanti-PD-1 monoclonal antibody spartalizumab (PDR001) and with ipilimumab in an ongoing FIH study

BERKELEY, Calif., November 9, 2018 – Aduro Biotech, Inc. (NASDAQ: ADRO) today announced presentation of preliminary data from its ongoing Phase 1 dose-finding study ofADU-S100 (MIW815), a novel STING (stimulator of interferon genes) pathway activator, at SITC 2018 in Washington, D.C. Aduro and collaborator Novartis embarked on thisfirst-in-human trial (see www.clinicaltrials.gov, identifier NCT02675439) as an important first step in characterizing the safety profile and mechanism ofADU-S100 and its ability to activate the STING pathway.

Data Highlights fromADU-S100 Monotherapy Trial (Datacut-off: August 16, 2018)

The Phase 1 dose escalation and dose expansion clinical trial is designed to evaluate the safety, tolerability and clinical activity ofADU-S100 in patients with advanced, metastatic treatment-refractory solid tumors or lymphomas. In this multicenter, open-label trial,ADU-S100 is administered intratumorally on Days 1, 8 and 15 of a28-day cycle.

• The trial has enrolled 41 patients, with 40 patients evaluated for response. The median number of prior anti-cancer treatments was four (range0-15). More than half of patients (53.7%) received prior therapy with a checkpoint inhibitor.

• More than 20 types of cancer have been treated in this trial, including Merkel cell, parotid gland, colorectal, endometrial, ER+ and triple-negative breast cancer, esophageal, collecting duct carcinoma, ovarian, Hodgkin’s disease, hemangioepithelioma and other cancers.

• Doses of50-3200 mcg have been explored in this presentation; enrollment is ongoing for additional patient cohorts.

• No dose-limiting toxicities have been reported at these dose levels. The most common (³10% of patients) treatment-related adverse events (TRAEs) were pyrexia, injection site pain and headache. Grade 3/4 TRAEs included increased lipase and elevated amylase, tumor pain, dyspnea, respiratory failure and injection site reaction.

Clinical and Biomarker Activity

• Importantly, increases in key systemic cytokines, includingIL-6,MCP-1 and IFN-ß, were observed after administration, indicating target engagement ofADU-S100 and activation of the STING pathway.

• Two of the 40 patients treated had a partial response (PR) – one patient with Merkel cell carcinoma and one patient with parotid gland cancer who had received prioranti-PD-1 therapy.

• 11 patients achieved stable disease (SD), including five patients who had received prior checkpoint inhibitor therapy.

• Three patients with SD remain on study and continue to receive treatment, including one patient with collecting duct carcinoma who has been on study for greater than one year.

• On-treatment tumor biopsies showed increases in CD8+ T cells in injected tumors in a subset of patients, including those with Merkel cell, collecting duct and esophageal carcinomas. Aduro and Novartis are continuing to evaluate additional pathology and other biomarkers to assess the pharmacological activity ofADU-S100 in these patients.

“We are encouraged by the data obtained from the dose escalation portion of thisfirst-in-human trial ofADU-S100 in heavilypre-treated patients with a diverse set of advanced cancers,” commented Stephen T. Isaacs, chairman and chief executive officer of Aduro Biotech. “Based on the safety profile and interesting signals observed from the clinical approach to date, we expect to collect additional biomarker data and have begun to enrich monotherapy dose cohorts with additional patients of select tumor types. At the same time, we have expanded the breadth of our joint development program with our colleagues at Novartis to focus on combination with checkpoint inhibitors in melanoma and other homogeneous patient populations where we seek to deliver clinical benefit to patients in need.”

In September 2018, this trial was amended to include a study arm evaluatingADU-S100 in combination with ipilimumab at its approved dose and schedule. Following a short dose escalation, the expansion phase aims to enroll patients with cutaneously and viscerally accessible melanoma who have relapsed or are refractory toPD-1 inhibitors.

Ongoing Phase 1b Trial ofADU-S100 +Anti-PD-1 Monoclonal Antibody Spartalizumab (PDR001)

A Phase 1b dose escalation and dose expansion clinical trial is ongoing to evaluate the safety and preliminary efficacy ofADU-S100 in combination with spartalizumab (PDR001), Novartis’ investigationalanti-PD-1 monoclonal antibody (see www.clinicaltrials.gov, identifier NCT03172936). The multicenter, open-label trial is currently enrolling patients with advanced, metastatic treatment-refractory solid tumors or lymphomas and is evaluating two treatment schedules ofADU-S100 in dose escalation with a

fixed dose of spartalizumab. Patients in Group A receive a fixed dose of intravenous spartalizumab on day 1 and an intratumoral injection ofADU-S100 three times (day 1, 8, 15) in a28-day cycle. Patients in Group B receive a fixed dose of intravenous spartalizumab on day 1 and an intratumoral injection ofADU-S100 on day 1 of every28-day cycle.

• The dose escalation combination trial has enrolled 50 patients with multiple cancers and who received multiple lines of prior therapies including prior immunotherapy.

• Patients have been treated with full-dose PDR001 and increasing dosing of intratumoralADU-S100(50-400mcg); enrollment is ongoing for additional patient cohorts.

• No dose-limiting toxicities have been reported.

In the early dosing cohorts of the ongoing study ofADU-S100 in combination with spartalizumab, preliminary observations include: 1) clinical responses observed in several tumor types, including two patients who had previously demonstrated responses to checkpoint inhibitor therapy alone; 2) reduced tumor volume in injected andnon-injected lesions in some patients; 3) several patients remained on study longer than 6 months; and 4) safety profile consistent with what has been observed in theADU-S100 monotherapy study.

Isaacs continued, “While still early, the preliminary observations emerging from initial dose cohorts ofADU-S100 plus spartalizumab are promising. In particular, the observation of clinical benefit in patients who received priorPD-1 therapy may provide further evidence supporting the synergy between STING and checkpoint inhibitor therapy that was previously demonstrated by our preclinical results. Extensive biomarker analysis is ongoing to assess biological activity. We and Novartis are committed to further exploration of the potential ofADU-S100 as a combination agent with both spartalizumab and ipilimumab in dose escalation and expansion into homogeneous patient populations. We look forward to seeing how these data evolve over time and expect to report on the results of these studies at future medical meetings.”

About STING Pathway Activator Technology

The Aduro-proprietary STING pathway activator product candidates, includingADU-S100 (MIW815), are synthetic small molecule immune modulators that are designed to target and activate human STING. STING is generally expressed at high levels in immune cells, including dendritic cells. Natural activation of STING is not always sufficient to prevent the growth and spread of cancer cells. In preclinical models,ADU-S100 directly activates STING to further amplify the natural anti-tumor response. Once activated, the STING receptor initiates a profound innate immune response through multiple pathways, inducing the expression of a broad profile of cytokines, including interferons and chemokines. This subsequently leads to the development of a systemic tumor antigen-specific T cell adaptive immune response.

Aduro’s lead molecule,ADU-S100, is the first therapeutic in development specifically targeting STING. In collaboration with Novartis, it is being tested in a Phase 1 clinical trial as a single agent and in combination with ipilimumab, and in a Phase 1b combination trial with spartalizumab (PDR001), an investigationalanti-PD-1 monoclonal antibody. These studies are enrolling patients with cutaneously accessible, advanced/metastatic solid tumors or lymphomas. The trials are evaluating the ability ofADU-S100 to activate the immune system and recruit specialized immune cells to attack the injected tumor, leading to a broad immune response that seeks out and kills distant metastases.

About Aduro

Aduro Biotech, Inc. is an immunotherapy company focused on the discovery, development and commercialization of therapies that are intended to transform the treatment of challenging diseases. Aduro’s technologies, which are designed to harness the body’s natural immune system, are being investigated in cancer indications, autoimmune diseases and have the potential to expand into infectious diseases. Aduro’s STING pathway activator technology is designed to activate the STING receptor in immune cells, which may result in a potent tumor-specific immune response.ADU-S100 (MIW815) is the first STING pathway activator compound to enter the clinic and is currently being evaluated in a Phase 1 clinical trial as a single agent and in combination with ipilimumab and in a Phase 1b combination trial with spartalizumab (PDR001), an investigationalanti-PD-1 monoclonal antibody. Aduro’sB-select monoclonal antibody technology, including BION-1301, an anti-APRIL antibody, is comprised of a number of immune modulating assets in research and development. Aduro is collaborating with leading global pharmaceutical companies to expand its products and technologies. For more information, please visit www.aduro.com.

Cautionary Note on Forward-Looking Statements

This press release contains forward-looking statements for purposes of the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. Forward-looking statements include statements regarding our intentions or current expectations concerning, among other things, the potential forADU-S100 alone or in combination, preliminary observations from early dose cohorts in the Phase 1b trial ofADU-S100 in combination with spartalizumab, the timing of clinical data, our and Novartis’ commitment to continue to exploreADU-S100 as a combination agent and our ability to advance our drug development programs on our own or with our collaborators. In some cases you can identify these statements by forward-looking words such as “may,” “will,” “continue,” “anticipate,” “intend,” “could,” “project,” “expect” or the negative or plural of these words or similar expressions. Forward-looking statements are not guarantees of future performance and are subject to risks and uncertainties that could cause actual results and events to differ materially from those anticipated, including, but not limited to, early or preliminary clinical trial results may not be predictive of future results, our history of net operating losses and uncertainty regarding our ability to achieve profitability, our ability to develop and commercialize our product candidates, our ability to use and expand our technologies to build a pipeline of product candidates, our ability to obtain and maintain regulatory approval of our product candidates, our ability to operate in a competitive industry and compete successfully against competitors that have greater resources than we do, our reliance on third parties, and our ability to obtain and adequately protect intellectual property rights for our product candidates. We discuss many of these risks in greater detail under the heading “Risk Factors” contained in our quarterly report on Form10-Q for the quarter ended September 30, 2018, which is on file with the Securities and Exchange Commission. Any forward-looking statements that we make in this press release speak only as of the date of this press release. We assume no obligation to update our forward-looking statements whether as a result of new information, future events or otherwise, after the date of this press release.