| Cover | 12 Months Ended |
| Dec. 31, 2022 | |
| Document Information [Line Items] | |
| Document Type | DEF 14A |
| Amendment Flag | false |
| Entity Information [Line Items] | |
| Entity Registrant Name | Agios Pharmaceuticals, Inc. |
| Entity Central Index Key | 0001439222 |
| Pay vs Performance Disclosure - USD ($) | 5 Months Ended | 7 Months Ended | 12 Months Ended | ||
| Dec. 31, 2022 | Aug. 08, 2022 | Dec. 31, 2022 | Dec. 31, 2021 | Dec. 31, 2020 | |
| Pay vs Performance Disclosure [Table] | |||||
| Pay vs Performance [Table Text Block] | Pay Versus Performance Disclosure In Non-PEO Year Summary Summary 1 Compensation 1,2,3 Compensation 1,2,3 Average Non-PEO 1 Average Non-PEO 1,2,3 Value of 4 Net Net 5 ($ Millions) TSR Peer (a) (b) (b) (c) (c) (d) (e) (f) (g) (h) (i) 2022 4,911,049 11,744,447 3,809,001 11,143,330 1,958,794 1,440,120 58.81 113.65 (232 ) 11.74 2021 6,519,427 — 1,457,816 — 2,188,153 857,046 68.84 126.45 1,605 0.00 2020 7,611,975 — 4,331,979 — 2,444,510 1,212,140 90.74 126.42 (327 ) 0.00 (1) Jacqualyn A. Fouse, Ph.D. was our PEO for 2020, 2021 and until August 8, 2022. Brian Goff became our PEO on August 8, 2022. The individuals comprising the Non-PEO 2020 2021 2022 Jonathan Biller Jonathan Biller Jonathan Biller Christopher Bowden Christopher Bowden Bruce Car, Ph.D. Bruce Car, Ph.D. Bruce Car, Ph.D. Sarah Gheuens, M.D., Ph.D. Andrew Hirsch Richa Poddar Richa Poddar Darrin Miles Cecilia Jones James Burns (2) The amounts shown for Compensation Actually Paid have been calculated in accordance with Item 402(v) of Regulation S-K (3) Compensation Actually Paid reflects the exclusions and inclusions of certain amounts for the PEOs and the Non-PEO Year Summary Exclusion of Stock Inclusion of Equity Compensation 2022 4,911,049 (4,141,027 ) 3,038,979 3,809,001 2021 6,519,427 (5,202,524 ) 140,913 1,457,816 2020 7,611,975 (6,344,991 ) 3,064,995 4,331,979 Year Summary Exclusion of Stock Inclusion of Equity Compensation 2022 11,744,447 (10,981,074 ) 10,379,957 11,143,330 Year Average Non-PEO NEOs Average Exclusion Non-PEO Average Inclusion Non-PEO Average Non-PEO 2022 1,958,794 (1,316,012 ) 797,338 1,440,120 2021 2,188,153 (1,505,538 ) 174,431 857,046 2020 2,444,510 (1,438,483 ) 206,113 1,212,140 The amounts in the Inclusion of Equity Values in the tables above are derived from the amounts set forth in the following tables: Year Year-End Fair Change in Fair Vesting-Date Fair Change in Fair Value Fair Value at Total—Inclusion 2022 3,843,712 (630,207 ) — (174,526 ) — 3,038,979 2021 2,521,442 (2,463,970 ) — 83,440 — 140,913 2020 4,535,365 (1,405,815 ) — (64,555 ) — 3,064,995 Year Year-End Fair Change in Fair Value Vesting-Date Fair Change in Fair Value Fair Value at Total—Inclusion 2022 10,379,957 — — — — 10,379,957 Year Average Year-End Non-PEO Average Change Non-PEO Average Vesting- Non-PEO Average Change Non-PEO Average Fair Non-PEO Total—Average Non-PEO 2022 1,014,787 (51,409 ) 0 29,385 (195,425 ) 797,338 2021 606,981 (251,863 ) 0 34,460 (215,147 ) 174,431 2020 757,947 (179,034 ) 68,534 58,187 (499,520 ) 206,113 (4) The Peer Group TSR set forth in this table utilizes the NASDAQ Biotechnology Index (“NASDAQ Biotech Index”), which we also utilize in the stock performance graph required by Item 201(e) of Regulation S-K (5) We determined net product revenue to be the most important financial performance measure used to link our performance to Compensation Actually Paid to our PEOs and Non-PEO | ||||
| Company Selected Measure Name | Net product revenue | ||||
| Named Executive Officers, Footnote [Text Block] | 2020 2021 2022 Jonathan Biller Jonathan Biller Jonathan Biller Christopher Bowden Christopher Bowden Bruce Car, Ph.D. Bruce Car, Ph.D. Bruce Car, Ph.D. Sarah Gheuens, M.D., Ph.D. Andrew Hirsch Richa Poddar Richa Poddar Darrin Miles Cecilia Jones James Burns | ||||
| Peer Group Issuers, Footnote [Text Block] | The Peer Group TSR set forth in this table utilizes the NASDAQ Biotechnology Index (“NASDAQ Biotech Index”), which we also utilize in the stock performance graph required by Item 201(e) of Regulation S-K | ||||
| Adjustment To PEO Compensation, Footnote [Text Block] | Year Summary Exclusion of Stock Inclusion of Equity Compensation 2022 4,911,049 (4,141,027 ) 3,038,979 3,809,001 2021 6,519,427 (5,202,524 ) 140,913 1,457,816 2020 7,611,975 (6,344,991 ) 3,064,995 4,331,979 Year Summary Exclusion of Stock Inclusion of Equity Compensation 2022 11,744,447 (10,981,074 ) 10,379,957 11,143,330 Year Year-End Fair Change in Fair Vesting-Date Fair Change in Fair Value Fair Value at Total—Inclusion 2022 3,843,712 (630,207 ) — (174,526 ) — 3,038,979 2021 2,521,442 (2,463,970 ) — 83,440 — 140,913 2020 4,535,365 (1,405,815 ) — (64,555 ) — 3,064,995 Year Year-End Fair Change in Fair Value Vesting-Date Fair Change in Fair Value Fair Value at Total—Inclusion 2022 10,379,957 — — — — 10,379,957 | ||||
| Non-PEO NEO Average Total Compensation Amount | $ 1,958,794 | $ 2,188,153 | $ 2,444,510 | ||
| Non-PEO NEO Average Compensation Actually Paid Amount | $ 1,440,120 | 857,046 | 1,212,140 | ||
| Adjustment to Non-PEO NEO Compensation Footnote [Text Block] | Year Average Non-PEO NEOs Average Exclusion Non-PEO Average Inclusion Non-PEO Average Non-PEO 2022 1,958,794 (1,316,012 ) 797,338 1,440,120 2021 2,188,153 (1,505,538 ) 174,431 857,046 2020 2,444,510 (1,438,483 ) 206,113 1,212,140 Year Average Year-End Non-PEO Average Change Non-PEO Average Vesting- Non-PEO Average Change Non-PEO Average Fair Non-PEO Total—Average Non-PEO 2022 1,014,787 (51,409 ) 0 29,385 (195,425 ) 797,338 2021 606,981 (251,863 ) 0 34,460 (215,147 ) 174,431 2020 757,947 (179,034 ) 68,534 58,187 (499,520 ) 206,113 | ||||
| Compensation Actually Paid vs. Total Shareholder Return [Text Block] | |||||
| Compensation Actually Paid vs. Net Income [Text Block] | |||||
| Compensation Actually Paid vs. Company Selected Measure [Text Block] | |||||
| Total Shareholder Return Vs Peer Group [Text Block] | |||||
| Tabular List [Table Text Block] | Tabular List of Most Important Financial and Non-Financial The following table presents the financial and non-financial Non-PEO Non-PEO Net Product Revenue Clinical Milestones Research Milestones | ||||
| Total Shareholder Return Amount | $ 58.81 | 68.84 | 90.74 | ||
| Peer Group Total Shareholder Return Amount | 113.65 | 126.45 | 126.42 | ||
| Net Income (Loss) | $ (232,000,000) | $ 1,605,000,000 | $ (327,000,000) | ||
| Company Selected Measure Amount | 11,740,000 | 0 | 0 | ||
| Measure [Axis]: 1 | |||||
| Pay vs Performance Disclosure [Table] | |||||
| Measure Name | Net Product Revenue | ||||
| Measure [Axis]: 2 | |||||
| Pay vs Performance Disclosure [Table] | |||||
| Measure Name | Clinical Milestones | ||||
| Measure [Axis]: 3 | |||||
| Pay vs Performance Disclosure [Table] | |||||
| Measure Name | Research Milestones | ||||
| Jacqualyn A Fouse Ph D [Member] | |||||
| Pay vs Performance Disclosure [Table] | |||||
| PEO Total Compensation Amount | $ 4,911,049 | $ 6,519,427 | $ 7,611,975 | ||
| PEO Actually Paid Compensation Amount | 3,809,001 | $ 1,457,816 | $ 4,331,979 | ||
| PEO Name | Jacqualyn A. Fouse, Ph.D. | Jacqualyn A. Fouse, Ph.D. | Jacqualyn A. Fouse, Ph.D. | ||
| Brian Goff [Member] | |||||
| Pay vs Performance Disclosure [Table] | |||||
| PEO Total Compensation Amount | 11,744,447 | $ 0 | $ 0 | ||
| PEO Actually Paid Compensation Amount | 11,143,330 | 0 | 0 | ||
| PEO Name | Brian Goff | ||||
| PEO [Member] | Jacqualyn A Fouse Ph D [Member] | Exclusion of Stock Awards and Option Awards [Member] | |||||
| Pay vs Performance Disclosure [Table] | |||||
| Adjustment to Compensation Amount | (4,141,027) | (5,202,524) | (6,344,991) | ||
| PEO [Member] | Jacqualyn A Fouse Ph D [Member] | Inclusion of Equity Values [Member] | |||||
| Pay vs Performance Disclosure [Table] | |||||
| Adjustment to Compensation Amount | 3,038,979 | 140,913 | 3,064,995 | ||
| PEO [Member] | Jacqualyn A Fouse Ph D [Member] | YearEnd Fair Value of Equity Awards Granted During Year That Remained Outstanding and Unvested as of Last Day of Year [Member] | |||||
| Pay vs Performance Disclosure [Table] | |||||
| Adjustment to Compensation Amount | 3,843,712 | 2,521,442 | 4,535,365 | ||
| PEO [Member] | Jacqualyn A Fouse Ph D [Member] | Change in Fair Value from Last Day of Prior Year to Last Day of Year of Outstanding and Unvested Equity Awards Granted in any Prior Year [Member] | |||||
| Pay vs Performance Disclosure [Table] | |||||
| Adjustment to Compensation Amount | (630,207) | (2,463,970) | (1,405,815) | ||
| PEO [Member] | Jacqualyn A Fouse Ph D [Member] | VestingDate Fair Value of Equity Awards Granted During Year that Vested During Year [Member] | |||||
| Pay vs Performance Disclosure [Table] | |||||
| Adjustment to Compensation Amount | 0 | 0 | 0 | ||
| PEO [Member] | Jacqualyn A Fouse Ph D [Member] | Change in Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards Granted in any Prior Year that Vested During Year [Member] | |||||
| Pay vs Performance Disclosure [Table] | |||||
| Adjustment to Compensation Amount | (174,526) | 83,440 | (64,555) | ||
| PEO [Member] | Jacqualyn A Fouse Ph D [Member] | Fair Value at Last Day of Prior Year of Equity Awards Forfeited During Year [Member] | |||||
| Pay vs Performance Disclosure [Table] | |||||
| Adjustment to Compensation Amount | 0 | 0 | 0 | ||
| PEO [Member] | Brian Goff [Member] | Exclusion of Stock Awards and Option Awards [Member] | |||||
| Pay vs Performance Disclosure [Table] | |||||
| Adjustment to Compensation Amount | (10,981,074) | ||||
| PEO [Member] | Brian Goff [Member] | Inclusion of Equity Values [Member] | |||||
| Pay vs Performance Disclosure [Table] | |||||
| Adjustment to Compensation Amount | 10,379,957 | ||||
| PEO [Member] | Brian Goff [Member] | YearEnd Fair Value of Equity Awards Granted During Year That Remained Outstanding and Unvested as of Last Day of Year [Member] | |||||
| Pay vs Performance Disclosure [Table] | |||||
| Adjustment to Compensation Amount | 10,379,957 | ||||
| PEO [Member] | Brian Goff [Member] | Change in Fair Value from Last Day of Prior Year to Last Day of Year of Outstanding and Unvested Equity Awards Granted in any Prior Year [Member] | |||||
| Pay vs Performance Disclosure [Table] | |||||
| Adjustment to Compensation Amount | 0 | ||||
| PEO [Member] | Brian Goff [Member] | VestingDate Fair Value of Equity Awards Granted During Year that Vested During Year [Member] | |||||
| Pay vs Performance Disclosure [Table] | |||||
| Adjustment to Compensation Amount | 0 | ||||
| PEO [Member] | Brian Goff [Member] | Change in Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards Granted in any Prior Year that Vested During Year [Member] | |||||
| Pay vs Performance Disclosure [Table] | |||||
| Adjustment to Compensation Amount | 0 | ||||
| PEO [Member] | Brian Goff [Member] | Fair Value at Last Day of Prior Year of Equity Awards Forfeited During Year [Member] | |||||
| Pay vs Performance Disclosure [Table] | |||||
| Adjustment to Compensation Amount | 0 | ||||
| Non-PEO NEO [Member] | Exclusion of Stock Awards and Option Awards [Member] | |||||
| Pay vs Performance Disclosure [Table] | |||||
| Adjustment to Compensation Amount | (1,316,012) | (1,505,538) | (1,438,483) | ||
| Non-PEO NEO [Member] | Inclusion of Equity Values [Member] | |||||
| Pay vs Performance Disclosure [Table] | |||||
| Adjustment to Compensation Amount | 797,338 | 174,431 | 206,113 | ||
| Non-PEO NEO [Member] | YearEnd Fair Value of Equity Awards Granted During Year That Remained Outstanding and Unvested as of Last Day of Year [Member] | |||||
| Pay vs Performance Disclosure [Table] | |||||
| Adjustment to Compensation Amount | 1,014,787 | 606,981 | 757,947 | ||
| Non-PEO NEO [Member] | Change in Fair Value from Last Day of Prior Year to Last Day of Year of Outstanding and Unvested Equity Awards Granted in any Prior Year [Member] | |||||
| Pay vs Performance Disclosure [Table] | |||||
| Adjustment to Compensation Amount | (51,409) | (251,863) | (179,034) | ||
| Non-PEO NEO [Member] | VestingDate Fair Value of Equity Awards Granted During Year that Vested During Year [Member] | |||||
| Pay vs Performance Disclosure [Table] | |||||
| Adjustment to Compensation Amount | 0 | 0 | 68,534 | ||
| Non-PEO NEO [Member] | Change in Fair Value from Last Day of Prior Year to Vesting Date of Unvested Equity Awards Granted in any Prior Year that Vested During Year [Member] | |||||
| Pay vs Performance Disclosure [Table] | |||||
| Adjustment to Compensation Amount | 29,385 | 34,460 | 58,187 | ||
| Non-PEO NEO [Member] | Fair Value at Last Day of Prior Year of Equity Awards Forfeited During Year [Member] | |||||
| Pay vs Performance Disclosure [Table] | |||||
| Adjustment to Compensation Amount | $ (195,425) | $ (215,147) | $ (499,520) | ||
