The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||||||
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
|
COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
ABBVIE INC | COM | 00287Y109 | 42,566 | 317,163 | SH | DFND | 0 | 317,163 | 0 | ||
ADAPTIMMUNE THERAPEUTICS PLC | SPONDS ADR | 00653A107 | 10,020 | 9,320,584 | SH | DFND | 0 | 9,320,584 | 0 | ||
AERIE PHARMACEUTICALS INC | NOTE 1.500%10/0 | 00771VAB4 | 47,381 | 48,150,000 | PRN | DFND | 0 | 48,150,000 | 0 | ||
APELLIS PHARMACEUTICALS INC | COM | 03753U106 | 8,324 | 121,880 | SH | DFND | 0 | 121,880 | 0 | ||
ARCUS BIOSCIENCES INC | COM | 03969F109 | 88,505 | 3,383,233 | SH | DFND | 0 | 3,383,233 | 0 | ||
ARGENX SE | SPONSORED ADR | 04016X101 | 36,976 | 104,732 | SH | DFND | 0 | 104,732 | 0 | ||
ASTRAZENECA PLC | SPONSORED ADR | 046353108 | 31,632 | 576,800 | SH | DFND | 0 | 576,800 | 0 | ||
AVANTOR INC | COM | 05352A100 | 40,761 | 2,079,657 | SH | DFND | 0 | 2,079,657 | 0 | ||
AXSOME THERAPEUTICS INC | COM | 05464T104 | 74,057 | 1,659,733 | SH | DFND | 0 | 1,659,733 | 0 | ||
BCLS ACQUISITION CORP | COM CL A | G0904B105 | 4,650 | 464,103 | SH | DFND | 0 | 464,103 | 0 | ||
BIOCRYST PHARMACEUTICALS INC | COM | 09058V103 | 27,246 | 2,162,411 | SH | DFND | 0 | 2,162,411 | 0 | ||
BIOGEN INC | COM | 09062X103 | 44,536 | 166,800 | SH | Call | DFND | 0 | 166,800 | 0 | |
BIOGEN INC | COM | 09062X103 | 37,200 | 139,326 | SH | DFND | 0 | 139,326 | 0 | ||
BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 15,259 | 180,000 | SH | Call | DFND | 0 | 180,000 | 0 | |
BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 94,599 | 1,115,949 | SH | DFND | 0 | 1,115,949 | 0 | ||
BIOMARIN PHARMACEUTICAL INC | NOTE 0.599% 8/0 | 09061GAH4 | 45,604 | 45,910,000 | PRN | DFND | 0 | 45,910,000 | 0 | ||
BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 8,590 | 130,366 | SH | DFND | 0 | 130,366 | 0 | ||
CANO HEALTH INC | COM CL A | 13781Y103 | 6,736 | 776,893 | SH | DFND | 0 | 776,893 | 0 | ||
CARDINAL HEALTH INC | COM | 14149Y108 | 42,661 | 639,783 | SH | DFND | 0 | 639,783 | 0 | ||
CARIBOU BIOSCIENCES INC | COM | 142038108 | 63,300 | 6,000,000 | SH | DFND | 0 | 6,000,000 | 0 | ||
CELCUITY INC | COM | 15102K100 | 1,410 | 140,426 | SH | DFND | 0 | 140,426 | 0 | ||
CENTENE CORP DEL | COM | 15135B101 | 86,562 | 1,112,480 | SH | DFND | 0 | 1,112,480 | 0 | ||
CIGNA CORP NEW | COM | 125523100 | 39,207 | 141,300 | SH | DFND | 0 | 141,300 | 0 | ||
COMPASS PATHWAYS PLC | SPONSORED ADS | 20451W101 | 4,267 | 397,711 | SH | DFND | 0 | 397,711 | 0 | ||
CYTOKINETICS INC | COM NEW | 23282W605 | 119,430 | 2,465,016 | SH | DFND | 0 | 2,465,016 | 0 | ||
DANAHER CORPORATION | COM | 235851102 | 45,379 | 175,690 | SH | DFND | 0 | 175,690 | 0 | ||
DYNAVAX TECHNOLOGIES CORP | COM NEW | 268158201 | 39,728 | 3,805,370 | SH | DFND | 0 | 3,805,370 | 0 | ||
DYNAVAX TECHNOLOGIES CORP | NOTE 2.500% 5/1 | 268158AD4 | 6,328 | 5,000,000 | PRN | DFND | 0 | 5,000,000 | 0 | ||
EDITAS MEDICINE INC | COM | 28106W103 | 15,656 | 1,279,054 | SH | DFND | 0 | 1,279,054 | 0 | ||
EDWARDS LIFESCIENCES CORP | COM | 28176E108 | 39,684 | 480,256 | SH | DFND | 0 | 480,256 | 0 | ||
ELEVANCE HEALTH INC | COM | 036752103 | 11,719 | 25,800 | SH | DFND | 0 | 25,800 | 0 | ||
ERASCA INC | COM | 29479A108 | 56,667 | 7,264,981 | SH | DFND | 0 | 7,264,981 | 0 | ||
ESSA PHARMA INC | COM NEW | 29668H708 | 2,690 | 1,478,252 | SH | DFND | 0 | 1,478,252 | 0 | ||
GENERATION BIO CO | COM | 37148K100 | 16,003 | 3,013,712 | SH | DFND | 0 | 3,013,712 | 0 | ||
HCA HEALTHCARE INC | COM | 40412C101 | 32,206 | 175,235 | SH | DFND | 0 | 175,235 | 0 | ||
HORIZON THERAPEUTICS PUB L | SHS | G46188101 | 67,574 | 1,091,840 | SH | DFND | 0 | 1,091,840 | 0 | ||
HUMANA INC | COM | 444859102 | 80,574 | 166,066 | SH | DFND | 0 | 166,066 | 0 | ||
ICON PLC | SHS | G4705A100 | 24,763 | 134,740 | SH | DFND | 0 | 134,740 | 0 | ||
ICU MED INC | COM | 44930G107 | 24,134 | 160,250 | SH | DFND | 0 | 160,250 | 0 | ||
INTELLIA THERAPEUTICS INC | COM | 45826J105 | 19,299 | 344,868 | SH | DFND | 0 | 344,868 | 0 | ||
IO BIOTECH INC | COM | 449778109 | 5,851 | 2,159,155 | SH | DFND | 0 | 2,159,155 | 0 | ||
IQVIA HLDGS INC | COM | 46266C105 | 41,496 | 229,081 | SH | DFND | 0 | 229,081 | 0 | ||
IRHYTHM TECHNOLOGIES INC | COM | 450056106 | 61,853 | 493,721 | SH | DFND | 0 | 493,721 | 0 | ||
ITEOS THERAPEUTICS INC | COM | 46565G104 | 10,248 | 537,954 | SH | DFND | 0 | 537,954 | 0 | ||
IVERIC BIO INC | COM | 46583P102 | 4,598 | 256,284 | SH | DFND | 0 | 256,284 | 0 | ||
JAZZ PHARMACEUTICALS PLC | SHS USD | G50871105 | 76,233 | 571,936 | SH | DFND | 0 | 571,936 | 0 | ||
JIYA ACQUISITION CORP | COM CL A | 47760M102 | 4,627 | 464,103 | SH | DFND | 0 | 464,103 | 0 | ||
JOHNSON & JOHNSON | COM | 478160104 | 22,502 | 137,746 | SH | DFND | 0 | 137,746 | 0 | ||
JOUNCE THERAPEUTICS INC | COM | 481116101 | 9,581 | 4,094,488 | SH | DFND | 0 | 4,094,488 | 0 | ||
KARUNA THERAPEUTICS INC | COM | 48576A100 | 29,307 | 130,293 | SH | DFND | 0 | 130,293 | 0 | ||
LILLY ELI & CO | COM | 532457108 | 96,566 | 298,643 | SH | DFND | 0 | 298,643 | 0 | ||
MCKESSON CORP | COM | 58155Q103 | 35,962 | 105,811 | SH | DFND | 0 | 105,811 | 0 | ||
MERCK & CO INC | COM | 58933Y105 | 31,048 | 360,520 | SH | DFND | 0 | 360,520 | 0 | ||
MOLINA HEALTHCARE INC | COM | 60855R100 | 47,424 | 143,779 | SH | DFND | 0 | 143,779 | 0 | ||
MYRIAD GENETICS INC | COM | 62855J104 | 14,160 | 742,138 | SH | DFND | 0 | 742,138 | 0 | ||
NEVRO CORP | COM | 64157F103 | 26,262 | 563,560 | SH | DFND | 0 | 563,560 | 0 | ||
NEVRO CORP | NOTE 2.750% 4/0 | 64157FAC7 | 8,519 | 9,000,000 | PRN | DFND | 0 | 9,000,000 | 0 | ||
OAK STR HEALTH INC | COM | 67181A107 | 17,724 | 722,844 | SH | DFND | 0 | 722,844 | 0 | ||
OAK STR HEALTH INC | NOTE 3/1 | 67181AAB3 | 48,857 | 63,000,000 | PRN | DFND | 0 | 63,000,000 | 0 | ||
OUTSET MED INC | COM | 690145107 | 11,620 | 729,413 | SH | DFND | 0 | 729,413 | 0 | ||
PARDES BIOSCIENCES INC | COM | 69945Q105 | 528 | 285,170 | SH | DFND | 0 | 285,170 | 0 | ||
PENUMBRA INC | COM | 70975L107 | 39,342 | 207,500 | SH | Call | DFND | 0 | 207,500 | 0 | |
PENUMBRA INC | COM | 70975L107 | 68,262 | 360,030 | SH | DFND | 0 | 360,030 | 0 | ||
PMV PHARMACEUTICALS INC | COM | 69353Y103 | 10,176 | 855,164 | SH | DFND | 0 | 855,164 | 0 | ||
POINT BIOPHARMA GLOBAL INC | COM | 730541109 | 34,903 | 4,515,216 | SH | DFND | 0 | 4,515,216 | 0 | ||
PRAXIS PRECISION MEDICINES I | COM | 74006W108 | 7,851 | 3,458,525 | SH | DFND | 0 | 3,458,525 | 0 | ||
PROCEPT BIOROBOTICS CORP | COM | 74276L105 | 21,457 | 517,526 | SH | DFND | 0 | 517,526 | 0 | ||
PROTHENA CORP PLC | SHS | G72800108 | 4,881 | 80,500 | SH | Call | DFND | 0 | 80,500 | 0 | |
PROTHENA CORP PLC | SHS | G72800108 | 50,944 | 840,238 | SH | DFND | 0 | 840,238 | 0 | ||
PULMONX CORP | COM | 745848101 | 3,327 | 199,703 | SH | DFND | 0 | 199,703 | 0 | ||
SANA BIOTECHNOLOGY INC | COM | 799566104 | 4,149 | 691,464 | SH | DFND | 0 | 691,464 | 0 | ||
SEAGEN INC | COM | 81181C104 | 49,972 | 365,215 | SH | DFND | 0 | 365,215 | 0 | ||
SELECT SECTOR SPDR TR | TECHNOLOGY | 81369Y803 | 45,552 | 383,500 | SH | Put | DFND | 0 | 383,500 | 0 | |
SIGHT SCIENCES INC | COM | 82657M105 | 1,446 | 227,692 | SH | DFND | 0 | 227,692 | 0 | ||
SOPHIA GENETICS SA | ORDINARY SHARES | H82027105 | 2,314 | 879,913 | SH | DFND | 0 | 879,913 | 0 | ||
SYNDAX PHARMACEUTICALS INC | COM | 87164F105 | 30,976 | 1,289,073 | SH | DFND | 0 | 1,289,073 | 0 | ||
TENET HEALTHCARE CORP | COM NEW | 88033G407 | 28,090 | 544,583 | SH | DFND | 0 | 544,583 | 0 | ||
THERMO FISHER SCIENTIFIC INC | COM | 883556102 | 31,518 | 62,143 | SH | DFND | 0 | 62,143 | 0 | ||
UNIQURE NV | SHS | N90064101 | 44,899 | 2,393,311 | SH | DFND | 0 | 2,393,311 | 0 | ||
UNITEDHEALTH GROUP INC | COM | 91324P102 | 56,339 | 111,554 | SH | DFND | 0 | 111,554 | 0 | ||
VEEVA SYS INC | CL A COM | 922475108 | 33,370 | 202,387 | SH | DFND | 0 | 202,387 | 0 | ||
VERVE THERAPEUTICS INC | COM | 92539P101 | 40,149 | 1,168,808 | SH | DFND | 0 | 1,168,808 | 0 | ||
WATERS CORP | COM | 941848103 | 31,706 | 117,634 | SH | DFND | 0 | 117,634 | 0 | ||
WEREWOLF THERAPEUTICS INC | COM | 95075A107 | 12,699 | 2,815,654 | SH | DFND | 0 | 2,815,654 | 0 | ||
ZAI LAB LTD | ADR | 98887Q104 | 808 | 23,612 | SH | DFND | 0 | 23,612 | 0 |