Cover Page
Cover Page - shares | 9 Months Ended | |
Sep. 30, 2021 | Nov. 05, 2021 | |
Cover [Abstract] | ||
Document Type | 10-Q | |
Document Quarterly Report | true | |
Document Period End Date | Sep. 30, 2021 | |
Document Transition Report | false | |
Entity File Number | 001-38129 | |
Entity Registrant Name | Mersana Therapeutics, Inc. | |
Entity Incorporation, State or Country Code | DE | |
Entity Tax Identification Number | 04-3562403 | |
Entity Address, Address Line One | 840 Memorial Drive | |
Entity Address, City or Town | Cambridge | |
Entity Address, State or Province | MA | |
Entity Address, Postal Zip Code | 02139 | |
City Area Code | 617 | |
Local Phone Number | 498-0020 | |
Title of 12(b) Security | Common Stock, $0.0001 par value | |
Trading Symbol | MRSN | |
Security Exchange Name | NASDAQ | |
Entity Current Reporting Status | Yes | |
Entity Interactive Data Current | Yes | |
Entity Filer Category | Large Accelerated Filer | |
Entity Small Business | false | |
Entity Emerging Growth Company | false | |
Entity Shell Company | false | |
Entity Common Stock, Shares Outstanding | 71,911,833 | |
Entity Central Index Key | 0001442836 | |
Current Fiscal Year End Date | --12-31 | |
Document Fiscal Year Focus | 2021 | |
Document Fiscal Period Focus | Q3 | |
Amendment Flag | false |
Condensed Consolidated Balance
Condensed Consolidated Balance Sheets - USD ($) $ in Thousands | Sep. 30, 2021 | Dec. 31, 2020 |
Current assets: | ||
Cash and cash equivalents | $ 191,707 | $ 255,094 |
Prepaid expenses and other current assets | 7,649 | 3,486 |
Total current assets | 199,356 | 258,580 |
Property and equipment, net | 2,131 | 1,730 |
Operating lease right-of-use assets | 13,171 | 10,936 |
Other assets | 2,928 | 2,153 |
Total assets | 217,586 | 273,399 |
Current liabilities: | ||
Accounts payable | 5,868 | 8,340 |
Accrued expenses | 31,715 | 16,146 |
Deferred revenue | 3,955 | 3,987 |
Operating lease liabilities | 2,237 | 1,437 |
Short-term debt | 0 | |
Other liabilities | 247 | 93 |
Total current liabilities | 44,022 | 30,003 |
Long-term operating lease liabilities | 11,904 | 10,158 |
Long-term debt, net | 5,077 | 4,977 |
Other long-term liabilities | 1,034 | 174 |
Total liabilities | 62,037 | 45,312 |
Commitments | ||
Stockholders' equity: | ||
Preferred stock, $0.0001 par value; 25,000,000 shares authorized; 0 shares issued and outstanding at September 30, 2021 and December 31, 2020, respectively | 0 | 0 |
Common stock,$0.0001 par value; 175,000,000 shares authorized; 71,865,399 and 68,841,288 shares issued and outstanding at September 30, 2021 and December 31, 2020, respectively | 7 | 7 |
Additional paid-in capital | 557,038 | 508,499 |
Accumulated deficit | (401,496) | (280,419) |
Total stockholders’ equity | 155,549 | 228,087 |
Total liabilities and stockholders’ equity | $ 217,586 | $ 273,399 |
Condensed Consolidated Balanc_2
Condensed Consolidated Balance Sheets (Parenthetical) - $ / shares | Sep. 30, 2021 | Dec. 31, 2020 |
Stockholders' equity: | ||
Preferred stock, par value (in dollars per share) | $ 0.0001 | $ 0.0001 |
Preferred stock, shares authorized (in shares) | 25,000,000 | 25,000,000 |
Preferred stock, shares issued (in shares) | 0 | 0 |
Preferred stock, shares outstanding (in shares) | 0 | 0 |
Common stock, par value (in dollars per share) | $ 0.0001 | $ 0.0001 |
Common stock, shares authorized (in shares) | 175,000,000 | 175,000,000 |
Common stock, shares issued (in shares) | 71,865,399 | 68,841,288 |
Common stock, shares outstanding (in shares) | 71,865,399 | 68,841,288 |
Condensed Consolidated Statemen
Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended | ||
Sep. 30, 2021 | Sep. 30, 2020 | Sep. 30, 2021 | Sep. 30, 2020 | |
Income Statement [Abstract] | ||||
Collaboration revenue | $ 11 | $ 11 | $ 32 | $ 817 |
Operating expenses: | ||||
Research and development | 35,275 | 16,546 | 94,645 | 44,179 |
General and administrative | 10,124 | 5,881 | 26,214 | 15,988 |
Total operating expenses | 45,399 | 22,427 | 120,859 | 60,167 |
Other income (expense): | ||||
Interest income | 15 | 19 | 36 | 414 |
Interest expense | (98) | (92) | (286) | (267) |
Total other income (expense), net | (83) | (73) | (250) | 147 |
Net loss | (45,471) | (22,489) | (121,077) | (59,203) |
Other comprehensive loss | ||||
Unrealized gain (loss) on marketable securities | 0 | (2) | 0 | (25) |
Comprehensive loss | (45,471) | (22,491) | (121,077) | (59,228) |
Net loss attributable to common stockholders - basic | (45,471) | (22,489) | (121,077) | (59,203) |
Net loss attributable to common stockholders - diluted | $ (45,471) | $ (22,489) | $ (121,077) | $ (59,203) |
Net loss per share attributable to common stockholders - basic (in dollars per share) | $ (0.63) | $ (0.33) | $ (1.73) | $ (1) |
Net loss per share attributable to common stockholders - diluted (in dollars per share) | $ (0.63) | $ (0.33) | $ (1.73) | $ (1) |
Weighted-average number of shares of common stock used in net loss per share attributable to common stockholders - basic (in shares) | 71,753,004 | 68,419,192 | 70,129,236 | 59,086,202 |
Weighted-average number of shares of common stock used in net loss per share attributable to common stockholders - diluted (in shares) | 71,753,004 | 68,419,192 | 70,129,236 | 59,086,202 |
Condensed Consolidated Statem_2
Condensed Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands | Total | 2018 ATM | Public Stock Offering | 2020 ATM | Common Stock | Common Stock2018 ATM | Common StockPublic Stock Offering | Common Stock2020 ATM | Additional Paid-in Capital | Additional Paid-in Capital2018 ATM | Additional Paid-in CapitalPublic Stock Offering | Additional Paid-in Capital2020 ATM | Accumulated Other Comprehensive Income (Loss) | Accumulated Deficit |
Balance at beginning of period (in shares) at Dec. 31, 2019 | 45,388,023 | |||||||||||||
Balance at beginning of period at Dec. 31, 2019 | $ 78,318 | $ 5 | $ 270,662 | $ 25 | $ (192,374) | |||||||||
Increase (Decrease) in Stockholders' Equity | ||||||||||||||
Exercise of common stock warrant in exchange for common stock (in shares) | 2,574,971 | |||||||||||||
Exercise of stock options (in shares) | 43,055 | |||||||||||||
Exercise of stock options | 119 | 119 | ||||||||||||
Stock-based compensation expense | 1,609 | 1,609 | ||||||||||||
Other comprehensive income (loss) | (29) | (29) | ||||||||||||
Net (loss) income | (16,926) | (16,926) | ||||||||||||
Balance at end of period (in shares) at Mar. 31, 2020 | 48,006,049 | |||||||||||||
Balance at end of period at Mar. 31, 2020 | 63,091 | $ 5 | 272,390 | (4) | (209,300) | |||||||||
Balance at beginning of period (in shares) at Dec. 31, 2019 | 45,388,023 | |||||||||||||
Balance at beginning of period at Dec. 31, 2019 | 78,318 | $ 5 | 270,662 | 25 | (192,374) | |||||||||
Increase (Decrease) in Stockholders' Equity | ||||||||||||||
Net (loss) income | (59,203) | |||||||||||||
Balance at end of period (in shares) at Sep. 30, 2020 | 68,470,081 | |||||||||||||
Balance at end of period at Sep. 30, 2020 | 253,308 | $ 7 | 504,876 | 0 | (251,575) | |||||||||
Balance at beginning of period (in shares) at Mar. 31, 2020 | 48,006,049 | |||||||||||||
Balance at beginning of period at Mar. 31, 2020 | 63,091 | $ 5 | 272,390 | (4) | (209,300) | |||||||||
Increase (Decrease) in Stockholders' Equity | ||||||||||||||
Exercise of stock options (in shares) | 206,143 | |||||||||||||
Exercise of stock options | 1,296 | 1,296 | ||||||||||||
Stock-based compensation expense | 1,656 | 1,656 | ||||||||||||
Other comprehensive income (loss) | 6 | 6 | ||||||||||||
Net (loss) income | (19,786) | (19,786) | ||||||||||||
Issuance of common stock under public offering, net of issuance costs (in shares) | 10,900,599 | 9,200,000 | ||||||||||||
Issuance of common stock under public offering, net of issuance costs | $ 62,977 | $ 163,991 | $ 1 | $ 1 | $ 62,976 | $ 163,990 | ||||||||
Purchase of common stock under ESPP (in shares) | 68,419 | |||||||||||||
Purchase of common stock under ESPP | 333 | 333 | ||||||||||||
Balance at end of period (in shares) at Jun. 30, 2020 | 68,381,210 | |||||||||||||
Balance at end of period at Jun. 30, 2020 | 273,564 | $ 7 | 502,641 | 2 | (229,086) | |||||||||
Increase (Decrease) in Stockholders' Equity | ||||||||||||||
Stock issuance costs | $ 2,176 | $ 10,809 | ||||||||||||
Exercise of stock options (in shares) | 88,871 | |||||||||||||
Exercise of stock options | 317 | 317 | ||||||||||||
Stock-based compensation expense | 1,918 | 1,918 | ||||||||||||
Other comprehensive income (loss) | (2) | (2) | ||||||||||||
Net (loss) income | (22,489) | (22,489) | ||||||||||||
Balance at end of period (in shares) at Sep. 30, 2020 | 68,470,081 | |||||||||||||
Balance at end of period at Sep. 30, 2020 | 253,308 | $ 7 | 504,876 | 0 | (251,575) | |||||||||
Increase (Decrease) in Stockholders' Equity | ||||||||||||||
Exercise of stock options (in shares) | 359,359 | |||||||||||||
Exercise of stock options | 1,406 | 1,406 | ||||||||||||
Stock-based compensation expense | 1,989 | 1,989 | ||||||||||||
Net (loss) income | (28,844) | (28,844) | ||||||||||||
Purchase of common stock under ESPP (in shares) | 11,848 | |||||||||||||
Purchase of common stock under ESPP | 228 | 228 | ||||||||||||
Balance at end of period (in shares) at Dec. 31, 2020 | 68,841,288 | |||||||||||||
Balance at end of period at Dec. 31, 2020 | 228,087 | $ 7 | 508,499 | 0 | (280,419) | |||||||||
Increase (Decrease) in Stockholders' Equity | ||||||||||||||
Exercise of stock options (in shares) | 148,472 | |||||||||||||
Exercise of stock options | 764 | 764 | ||||||||||||
Vesting of restricted stock units, net of employee tax obligations (in shares) | 61,678 | |||||||||||||
Vesting of restricted stock units, net of employee tax obligations | (259) | (259) | ||||||||||||
Stock-based compensation expense | 4,039 | 4,039 | ||||||||||||
Net (loss) income | (34,693) | (34,693) | ||||||||||||
Balance at end of period (in shares) at Mar. 31, 2021 | 69,051,438 | |||||||||||||
Balance at end of period at Mar. 31, 2021 | 197,938 | $ 7 | 513,043 | 0 | (315,112) | |||||||||
Balance at beginning of period (in shares) at Dec. 31, 2020 | 68,841,288 | |||||||||||||
Balance at beginning of period at Dec. 31, 2020 | $ 228,087 | $ 7 | 508,499 | 0 | (280,419) | |||||||||
Increase (Decrease) in Stockholders' Equity | ||||||||||||||
Exercise of stock options (in shares) | 331,141 | |||||||||||||
Net (loss) income | $ (121,077) | |||||||||||||
Issuance of common stock under public offering, net of issuance costs (in shares) | 2,271,074 | |||||||||||||
Balance at end of period (in shares) at Sep. 30, 2021 | 71,865,399 | |||||||||||||
Balance at end of period at Sep. 30, 2021 | 155,549 | $ 7 | 557,038 | 0 | (401,496) | |||||||||
Balance at beginning of period (in shares) at Mar. 31, 2021 | 69,051,438 | |||||||||||||
Balance at beginning of period at Mar. 31, 2021 | 197,938 | $ 7 | 513,043 | 0 | (315,112) | |||||||||
Increase (Decrease) in Stockholders' Equity | ||||||||||||||
Exercise of stock options (in shares) | 42,506 | |||||||||||||
Exercise of stock options | 202 | 202 | ||||||||||||
Stock-based compensation expense | 4,582 | 4,582 | ||||||||||||
Net (loss) income | (40,913) | (40,913) | ||||||||||||
Issuance of common stock under public offering, net of issuance costs (in shares) | 2,271,074 | |||||||||||||
Issuance of common stock under public offering, net of issuance costs | $ 33,287 | $ 33,287 | ||||||||||||
Purchase of common stock under ESPP (in shares) | 36,198 | |||||||||||||
Purchase of common stock under ESPP | 417 | 417 | ||||||||||||
Balance at end of period (in shares) at Jun. 30, 2021 | 71,401,216 | |||||||||||||
Balance at end of period at Jun. 30, 2021 | 195,513 | $ 7 | 551,531 | 0 | (356,025) | |||||||||
Increase (Decrease) in Stockholders' Equity | ||||||||||||||
Stock issuance costs | $ 746 | |||||||||||||
Exercise of stock options (in shares) | 137,301 | |||||||||||||
Exercise of stock options | 579 | 579 | ||||||||||||
Vesting of restricted stock units, net of employee tax obligations (in shares) | 326,882 | |||||||||||||
Vesting of restricted stock units, net of employee tax obligations | 0 | 0 | ||||||||||||
Stock-based compensation expense | 4,928 | 4,928 | ||||||||||||
Net (loss) income | (45,471) | (45,471) | ||||||||||||
Balance at end of period (in shares) at Sep. 30, 2021 | 71,865,399 | |||||||||||||
Balance at end of period at Sep. 30, 2021 | $ 155,549 | $ 7 | $ 557,038 | $ 0 | $ (401,496) |
Condensed Consolidated Statem_3
Condensed Consolidated Statements of Stockholders' Equity (Parenthetical) - USD ($) $ in Thousands | 3 Months Ended | |
Jun. 30, 2021 | Jun. 30, 2020 | |
2018 ATM | ||
Stock issuance costs | $ 2,176 | |
Public Stock Offering | ||
Stock issuance costs | $ 10,809 | |
2020 ATM | ||
Stock issuance costs | $ 746 |
Condensed Consolidated Statem_4
Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 9 Months Ended | |
Sep. 30, 2021 | Sep. 30, 2020 | |
Cash flows from operating activities | ||
Net loss | $ (121,077) | $ (59,203) |
Adjustments to reconcile net loss to net cash used in operating activities: | ||
Depreciation | 644 | 750 |
Net amortization of premiums and discounts on investments | 0 | (86) |
Stock-based compensation | 13,549 | 5,183 |
Other non-cash items | 119 | 110 |
Changes in operating assets and liabilities: | ||
Prepaid expenses and other current assets | (4,104) | (2,460) |
Other assets | (617) | (700) |
Accounts payable | (2,429) | (2,766) |
Accrued expenses | 16,047 | 2,367 |
Operating lease assets | 1,548 | 1,235 |
Operating lease liabilities | (1,236) | (990) |
Deferred revenue | (32) | (817) |
Net cash used in operating activities | (97,588) | (57,377) |
Cash flows from investing activities | ||
Maturities of marketable securities | 0 | 37,500 |
Purchase of property and equipment | (493) | (285) |
Net cash provided by (used in) investing activities | (493) | 37,215 |
Cash flows from financing activities | ||
Proceeds from exercise of stock options | 1,545 | 1,732 |
Proceeds from purchases of common stock under ESPP | 417 | 333 |
Payment of employee tax obligations related to vesting of restricted stock units | (259) | 0 |
Proceeds from issuance of debt, net of issuance costs | 0 | (197) |
Payments under capital lease obligations | (139) | (87) |
Net cash provided by financing activities | 34,851 | 228,747 |
Increase (decrease) in cash, cash equivalents and restricted cash | (63,230) | 208,585 |
Cash, cash equivalents and restricted cash, beginning of period | 255,415 | 62,672 |
Cash, cash equivalents and restricted cash, end of period | 192,185 | 271,257 |
Supplemental disclosures of non-cash activities: | ||
Purchases of property and equipment in accounts payable and accrued expenses | 46 | 0 |
Cash paid for interest | 187 | 173 |
Right-of-use assets obtained in exchange for operating lease liabilities | 3,783 | 9,980 |
Right-of-use assets obtained in exchange for financing lease liabilities | 609 | 0 |
Public Stock Offering | ||
Cash flows from financing activities | ||
Net proceeds from public offering of common stock | 0 | 163,990 |
Net proceeds from the at-the-market (ATM) facility | 0 | 163,990 |
At Market Equity Offering Program | ||
Cash flows from financing activities | ||
Net proceeds from public offering of common stock | 33,287 | 62,976 |
Net proceeds from the at-the-market (ATM) facility | $ 33,287 | $ 62,976 |
Nature of business and basis of
Nature of business and basis of presentation | 9 Months Ended |
Sep. 30, 2021 | |
Organization, Consolidation and Presentation of Financial Statements [Abstract] | |
Nature of business and basis of presentation | Nature of business and basis of presentation Mersana Therapeutics, Inc. is a clinical stage biopharmaceutical company focused on developing antibody drug conjugates (ADCs) that offer a clinically meaningful benefit for cancer patients with significant unmet need. The Company has leveraged over 20 years of industry learning in the ADC field to develop proprietary and differentiated technology platforms that enable it to design ADCs to have improved efficacy, safety and tolerability relative to existing ADC therapies. The Company’s innovative platforms, which include Dolaflexin and Dolasynthen, each delivering its DolaLock payload, as well as Immunosynthen, delivering a novel stimulator of interferon genes (STING) agonist, provide an efficient product engine that has enabled a robust discovery pipeline for the Company and its partners. The Company’s clinical candidates include upifitamab rilsodotin (UpRi, XMT-1536) and XMT-1592. The Company’s early-stage programs include XMT-1660, a potentially first-in-class Dolasynthen ADC targeting B7-H4, as well as XMT-2056, a STING agonist ADC developed using the Company’s Immunosynthen platform, and targeting a novel epitope of human epidermal growth factor receptor 2 (HER2). UpRi, an ADC utilizing the Company’s Dolaflexin platform and targeting NaPi2b, an antigen broadly expressed in ovarian cancer and other cancers, is being studied in UPLIFT, a single-arm registration strategy in patients with platinum-resistant ovarian cancer, as well as in UPGRADE, a Phase 1 combination dose escalation umbrella study to evaluate the safety and efficacy of UpRi in combination with other ovarian cancer therapies. The Company also continues to study UpRi in the expansion portion of a Phase 1 proof-of-concept clinical study. XMT-1592 uses the Company’s Dolasynthen platform and also targets NaPi2b and is in the dose escalation portion of a Phase 1 proof-of-concept clinical study. The Company is subject to risks common to companies in the biotechnology industry including, but not limited to, the need for additional capital, risks of failure of preclinical and clinical studies, the need to obtain marketing approval and reimbursement for any drug product candidate that it may identify and develop, the need to successfully commercialize and gain market acceptance of its product candidates, dependence on key personnel, protection of proprietary technology, compliance with government regulations, development of technological innovations by competitors, reliance on third party manufacturers and the ability to transition from pilot-scale production to large-scale manufacturing of products. The Company has incurred cumulative net losses since inception. For the nine months ended September 30, 2021, the net loss was $121,077, compared to net loss of $59,203 in the nine months ended September 30, 2020. The Company expects to continue to incur operating losses for at least the next several years. As of September 30, 2021, the Company had an accumulated deficit of $401,496. The future success of the Company is dependent on, among other factors, its ability to identify and develop its product candidates and ultimately upon its ability to attain profitable operations. The Company has devoted substantially all of its financial resources and efforts to research and development and general and administrative expense to support such research and development. Net losses and negative operating cash flows have had, and will continue to have, an adverse effect on the Company’s stockholders' equity and working capital. The Company believes that its currently available funds will be sufficient to fund the Company’s operations through at least the next twelve months from the issuance of this Quarterly Report on Form 10-Q. Management’s belief with respect to its ability to fund operations is based on estimates that are subject to risks and uncertainties. If actual results are different from management’s estimates, the Company may need to seek additional funding. The Company’s unaudited condensed consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States (U.S. GAAP) and the rules and regulations of the Securities and Exchange Commission (SEC). Any reference in these notes to applicable guidance is meant to refer to the authoritative U.S. GAAP as found in the Accounting Standards Codification (ASC) and Accounting Standards Updates (ASU) of the Financial Accounting Standards Board (FASB). All dollar amounts, except per share data in the text and tables herein, are stated in thousands unless otherwise indicated. Certain information and footnote disclosures normally included in annual financial statements prepared in accordance with U.S. GAAP have been condensed or omitted from this report, as is permitted by such rules and regulations. Accordingly, these financial statements should be read in conjunction with the audited financial statements as of and for the year ended December 31, 2020 and the notes thereto, included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2020, filed with the SEC on February 26, 2021. The unaudited condensed consolidated financial statements have been prepared on the same basis as the audited financial statements. In the opinion of the Company’s management, the accompanying unaudited condensed consolidated financial statements contain all adjustments that are necessary to present fairly the Company’s financial position as of September 30, 2021, the results of its operations for the three and nine months ended September 30, 2021 and 2020, a statement of stockholders’ equity for the three and nine months ended September 30, 2021 and 2020 and cash flows for the nine months ended September 30, 2021 and 2020. Such adjustments are of a normal and recurring nature. The results for the three and nine months ended September 30, 2021 are not necessarily indicative of the results for the year ending December 31, 2021, or for any future period. |
Summary of Significant Accounti
Summary of Significant Accounting Policies | 9 Months Ended |
Sep. 30, 2021 | |
Accounting Policies [Abstract] | |
Summary of Significant Accounting Policies | Summary of Significant Accounting Policies Principles of Consolidation The accompanying unaudited condensed consolidated financial statements include those of the Company and its wholly owned subsidiary, Mersana Securities Corp. All intercompany balances and transactions have been eliminated. Use of Estimates The preparation of the Company’s unaudited condensed consolidated financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the reported amounts of assets, liabilities, equity, revenue, expenses and related disclosure of contingent assets and liabilities at the date of the financial statements and reported amounts of revenue and expenses during the reporting period. On an ongoing basis, the Company’s management evaluates its estimates which include, but are not limited to, management’s judgments with respect to the identification of performance obligations and standalone selling prices of those performance obligations within its revenue arrangements, accrued preclinical, manufacturing and clinical expenses, valuation of stock-based awards and income taxes. Actual results could differ from those estimates. Segment Information Operating segments are defined as components of an enterprise about which separate discrete information is available for evaluation by the chief operating decision-maker, or decision making group, in deciding how to allocate resources and assess performance. The Company views its operations and manages its business as a single operating segment, which is the business of discovering and developing ADCs. Summary of Accounting Policies The significant accounting policies used in preparation of these condensed consolidated financial statements for the three and nine months ended September 30, 2021 are consistent with those discussed in Note 2 to the consolidated financial statements in the Company’s 2020 Annual Report on Form 10-K, except as otherwise noted below in "Recently Issued Accounting Pronouncements." Fair Value Measurements Fair value is defined as the price that would be received upon sale of an asset or paid to transfer a liability between market participants at measurement dates. ASC Topic 820 Fair Value Measurement (ASC 820) establishes a three-level valuation hierarchy for instruments measured at fair value. The hierarchy is based on the transparency of inputs to the valuation of an asset or liability as of the measurement date. The three levels are defined as follows: Level 1—Inputs to the valuation methodology are quoted prices (unadjusted) for identical assets or liabilities in active markets. Level 2—Inputs to the valuation methodology include quoted prices for similar assets and liabilities in active markets, and inputs that are observable for the asset or liability, either directly or indirectly, for substantially the full term of the financial instrument. Level 3—Inputs to the valuation methodology are unobservable and significant to the fair value measurement. Cash and Cash Equivalents The Company considers all highly-liquid investments with an original maturity, or a remaining maturity at the time of purchase, of three months or less to be cash equivalents. The Company invests excess cash primarily in money market funds, commercial paper and government agency securities, which are highly liquid and have strong credit ratings. These investments are subject to minimal credit and market risks. Cash and cash equivalents are stated at cost, which approximates market value. Nine Months Ended Nine Months Ended Beginning End Beginning End Cash and cash equivalents $ 255,094 $ 191,707 $ 62,351 $ 270,936 Restricted cash included in other assets, noncurrent 321 478 321 321 Total cash, cash equivalents and restricted cash per statement of cash flows $ 255,415 $ 192,185 $ 62,672 $ 271,257 Other Assets The Company recorded other assets of $2,928 and $2,153 as of September 30, 2021 and December 31, 2020, respectively, comprised of $2,450 and $1,832, respectively, held by a service provider, and restricted cash of $478 and $321, respectively, held as a security deposit for a standby letter of credit related to a facility lease. Net Loss per Share Basic net loss per share of common stock is calculated by dividing the net loss attributable to common stockholders by the weighted-average number of shares of common stock outstanding during the period, without further consideration for potentially dilutive securities. Diluted net loss per share is computed by dividing the net loss attributable to common stockholders by the weighted-average number of shares of common stock and potentially dilutive securities outstanding for the period determined using the treasury stock method. For purposes of the diluted net loss per share calculation, stock options, unvested restricted stock units (RSUs) and warrants to purchase common stock are considered to be potentially dilutive securities, but are excluded from the calculation of diluted net loss per share because their effect would be anti-dilutive and therefore, basic and diluted net loss per share were the same for all periods presented. The following table sets forth the outstanding potentially dilutive securities that have been excluded from the calculation of diluted net loss per share because to include them would be anti-dilutive (in common stock equivalent shares): Three and Nine Months Ended Three and Nine Months Ended Stock options 8,215,549 6,215,368 Unvested restricted stock units 800,466 740,862 Warrants 39,474 39,474 9,055,489 6,995,704 Recently Issued Accounting Pronouncements In December 2019, the FASB issued ASU No. 2019-12, Income Taxes (Topic 740): Simplifying the Accounting for Income Taxes , as part of its initiative to reduce complexity in the accounting standards. The amendments in ASU 2019-12 eliminate certain exceptions related to the approach for intraperiod tax allocation, the methodology for calculating income taxes in an interim period and the recognition of deferred tax liabilities for outside basis differences. ASU 2019-12 also clarifies and simplifies other aspects of the accounting for income taxes. The amendments in ASU 2019-12 are effective for the fiscal years beginning after December 15, 2020. The adoption of ASU 2019-12 did not have a material effect on the Company's results of operations and financial position. |
Collaboration agreements
Collaboration agreements | 9 Months Ended |
Sep. 30, 2021 | |
Collaboration agreements | |
Collaboration agreements | Collaboration agreements Merck KGaA In June 2014, the Company entered into a Collaboration and Commercial License Agreement with Merck KGaA (the Merck KGaA Agreement). Upon the execution of the Merck KGaA Agreement, Merck KGaA paid the Company a nonrefundable technology access fee of $12,000 for the right to develop ADCs directed to six exclusive targets over a specified period of time. No additional fees are due when a target is designated and the commercial license to the target is granted. Merck KGaA will be responsible for the product development and marketing of any products resulting from this collaboration. All six targets were designated prior to 2018. The next potential milestone payment that the Company is eligible to receive is a development milestone of $500 on Merck KGaA’s designation of a preclinical development candidate for a target. Revenue will be recognized when achievement of the milestone is considered probable. Under the terms of the Merck KGaA Agreement, the Company and Merck KGaA develop research plans to evaluate Merck KGaA's antibodies as ADCs incorporating the Company's technology. The Company receives reimbursement for its efforts under the research plans. The goal of the research plans is to provide Merck KGaA with sufficient information to formally nominate a development candidate and begin IND-enabling studies or cease development on the designated target. In May 2018, the Company entered into a Supply Agreement with Merck KGaA (the Merck KGaA Supply Agreement). Under the terms of the Merck KGaA Supply Agreement, the Company will provide Merck KGaA preclinical non-GMP ADC drug substance and clinical GMP drug substance for use in clinical trials associated with one of the antibodies designated under the Merck KGaA Agreement. The Company receives fees for its efforts under the Merck KGaA Supply Agreement and reimbursement equal to the supply cost. The Company may also enter into future supply agreements to provide clinical supply material should Merck KGaA pursue clinical development of any other candidates nominated under the Merck KGaA Agreement. Accounting Analysis The Company identified the following performance obligations under the Merck KGaA Agreement: (i) exclusive license and research services for six designated targets, (ii) rights to future technological improvements and (iii) participation of project team leaders and providing joint research committee services. The Company is recognizing revenue related to the exclusive license and research and development services performance obligations over the estimated period of the research and development services using a proportional performance model. The Company measures proportional performance based on the costs incurred relative to the total costs expected to be incurred. To the extent that the Company receives fees for the research services as they are performed, these amounts are recorded as deferred revenue. Revenue related to future technological improvements and joint research committee services will be recognized ratably over the respective performance period (which in the case of the joint research committee services approximate the time and cost incurred each period), which are 10 and 5 years, respectively. The Company is continuing to reassess the estimated remaining term at each subsequent reporting period. As of September 30, 2021, the Company had completed its research service obligations associated with four of the six designated targets. During the three months ended September 30, 2021 and 2020, and the nine months ended September 30, 2021 and 2020, the Company recorded collaboration revenue of $11, $11, $32, and $817, respectively, related to its efforts under the Merck KGaA Agreement. The Company did not recognize any corresponding research and development expense related to the Merck KGaA Supply Agreement during the three and nine months ended September 30, 2021 and 2020. As of September 30, 2021 and December 31, 2020, the Company had $3,955 and $3,987, respectively, in deferred revenue related to the Merck KGaA Agreement and Merck KGaA Supply Agreement. Such amounts will be recognized over the remaining performance period. Summary of Contract Assets and Liabilities The following table presents changes in the balances of the Company's contract assets and liabilities during the nine months ended September 30, 2021 and 2020: Balance at Additions Deductions Balance at Nine months ended September 30, 2021 Contract assets $ — $ — $ — $ — Contract liabilities: Deferred revenue $ 3,987 $ — $ 32 $ 3,955 Balance at Additions Deductions Balance at Nine months ended September 30, 2020 Contract assets $ — $ — $ — $ — Contract liabilities: Deferred revenue $ 4,815 $ — $ 817 $ 3,998 During the three and nine months ended September 30, 2021 and 2020, the Company recognized the following revenues as a result of changes in the contract asset and the contract liability balances in the respective periods: Three Months Ended Nine Months Ended 2021 2020 2021 2020 Revenue recognized in the period from: Amounts included in the contract liability at the beginning of the period $ 11 $ 11 $ 32 $ 817 Performance obligations satisfied in previous periods $ — $ — $ — $ — Other Revenue The Company has provided limited services for a collaboration partner, Asana BioSciences. For each of the nine months ended September 30, 2021 and 2020, the Company did not recognize revenue related to these services. The next potential milestone the Company is eligible to receive is $2,500 upon dosing the fifth patient in a Phase 1 clinical study by Asana BioSciences. As of September 30, 2021, the Company considers this next milestone to be fully constrained as there is considerable judgment involved in determining whether it is probable that a significant revenue reversal would occur. As part of its evaluation of the constraint, the Company considered numerous factors, including the fact that achievement of the milestone is outside the control of the Company and there is a high level of uncertainty in achieving this milestone, as this would require successful initiation of clinical trials by the collaboration partner. The Company reevaluates the probability of achievement of a milestone subject to constraint at each reporting period and as uncertain events are resolved or other changes in circumstances occur. |
Fair value measurements
Fair value measurements | 9 Months Ended |
Sep. 30, 2021 | |
Fair Value Disclosures [Abstract] | |
Fair value measurements | Fair value measurements The carrying amounts reflected in the consolidated balance sheets for prepaid expenses and other current assets, accounts payable and accrued expenses approximate their fair values due to their short-term nature. As of September 30, 2021 and December 31, 2020, the carrying value of the Company’s outstanding borrowing under the Amended Credit Facility (as defined below) approximated fair value (a Level 2 fair value measurement), reflecting interest rates currently available to the Company. The Amended Credit Facility is discussed in more detail in Note 6, “Debt”. |
Accrued expenses
Accrued expenses | 9 Months Ended |
Sep. 30, 2021 | |
Accrued Liabilities, Current [Abstract] | |
Accrued expenses | Accrued expenses Accrued expenses consisted of the following as of September 30, 2021 and December 31, 2020: September 30, December 31, Accrued clinical expenses $ 12,057 $ 5,126 Accrued manufacturing expenses 8,951 4,157 Accrued preclinical expenses 2,864 619 Accrued payroll and related expenses 6,285 5,412 Accrued professional fees 1,449 757 Accrued other 109 75 $ 31,715 $ 16,146 |
Debt
Debt | 9 Months Ended |
Sep. 30, 2021 | |
Debt Disclosure [Abstract] | |
Debt | Debt On May 8, 2019, the Company entered into a loan and security agreement with Silicon Valley Bank ( SVB) , which was subsequently amended on June 21, 2019, August 28, 2020, and August 27, 2021 (as amended prior to the Third Amendment, as defined below, the Credit Facility and as amended by the Third Amendment, the Amended Credit Facility). Under the Credit Facility the Company can borrow term loans in an aggregate amount of $30,000, at its option, comprising (i) up to $25,000 in up to five principal advances through April 30, 2022 (Tranche A), and (ii) an additional $5,000 in one principal advance (Tranche B), if the Company reaches certain development milestone events, as described in the Amended Credit Facility, through April 30, 2022. On August 27, 2021, the Company entered into a third amendment (the Third Amendment) to its Credit Facility . Pursuant to the Third Amendment, the draw period for Tranche B has been extended. The Company can borrow the additional $5,000 in one principal advance, if the Company reaches certain development milestone events, as described in the Third Amendment, through July 31, 2022. In addition, the interest only period in relation to Tranche B has also been extended under certain circumstances. If Tranche B is drawn prior to June 1, 2022, then the interest only period remains June 1, 2022. However, if Tranche B is drawn between June 1, 2022 and July 31, 2022, then the interest only period extends to August 1, 2022 and may be further extended to February 1, 2023 if the Company reaches certain development milestones events, as described in the Third Amendment, through May 31, 2022. As of September 30, 2021, the Company was in compliance with all covenants under the Amended Credit Facility. As of September 30, 2021, the Company had drawn a term loan of $5,200, and debt consisted of the following: September 30, Total debt $ 5,200 Less: Current portion of long-term-debt — Total debt, net of current portion 5,200 Debt financing costs, net of accretion (197) Accretion related to final payment 74 Long-term debt, net $ 5,077 As of September 30, 2021, the estimated future principal payments due are as follows: 2021 (excluding the nine months ended September 30, 2021) $ — 2022 1,213 2023 2,080 2024 1,907 Total debt $ 5,200 During the three months ended September 30, 2021 and 2020, and the nine months ended September 30, 2021 and 2020, the Company recognized $90, $60, $267, and $173, respectively, of interest expense related to the Amended Credit Facility. |
Stockholders' equity
Stockholders' equity | 9 Months Ended |
Sep. 30, 2021 | |
Stockholders' Equity Note [Abstract] | |
Stockholders’ equity | Stockholders’ equity Preferred stock As of September 30, 2021, the Company had 25,000,000 shares of authorized preferred stock. No shares of preferred stock have been issued. At-the-market equity offering program In July 2018, the Company established an at-the-market (ATM) equity offering program (the 2018 ATM) pursuant to which it could offer and sell up to $75,000 of its common stock from time to time at prevailing market prices. In April 2020, the Company sold 8,938,599 and 1,962,000 shares of common stock at $5.59 per share and $7.74 per share, respectively, to raise aggregate gross proceeds of $65,153 through the 2018 ATM facility. Net proceeds to the Company after deducting fees, commissions and other expenses related to the offering were $62,976. In May 2020, the Company terminated the 2018 ATM and established a new ATM equity offering program (the 2020 ATM) pursuant to which it is able to sell up to $100,000 of its common stock from time to time at prevailing market prices. For the nine months ended September 30, 2021, the Company sold 2,271,074 shares of common stock at an average price of $14.99 per share to raise aggregate gross proceeds of $34,033 through the 2020 ATM. Net proceeds to the Company after deducting fees, commissions and other expenses related to the offering were $33,287. Follow-on offering In June 2020, the Company sold 9,200,000 shares of common stock, in an underwritten public offering at a price to the public of $19.00 per share. Net proceeds to the Company after deducting fees, commissions and other expenses related to the offering were $163,990. Warrants In connection with a 2013 Series A-1 Preferred Stock issuance, the Company granted to certain investors warrants to purchase 129,491 shares of common stock. The warrants have a $0.05 per share exercise price and a contractual life of 10 years. The fair value of these warrants was recorded as a component of equity at the time of issuance. As of September 30, 2021, there were warrants to purchase 39,474 shares of common stock. During the quarter ended September 30, 2021, there were no exercises of warrants in exchange for shares of common stock. Exchange warrants On November 26, 2019, the Company entered into an exchange agreement with entities affiliated with Biotechnology Value Fund, L.P. (the Exchanging Stockholders), pursuant to which the Exchanging Stockholders exchanged an aggregate of 2,575,000 shares of common stock for warrants (the Exchange Warrants) to purchase an aggregate of 2,575,000 shares of common stock (subject to adjustment in the event of any stock dividends and splits, reverse stock split, merger or consolidation, change of control, reorganization or similar transaction, as described in the Exchange Warrants), with an exercise price of $0.0001 per share. On March 2, 2020, the Exchanging Stockholders exercised the Exchange Warrants in full on a net cashless exercise basis, resulting in the issuance of 2,574,971 shares of common stock. Common stock The holders of the common stock are entitled to one vote for each share held. Common stockholders are not entitled to receive dividends, unless declared by the Board of Directors (the Board). At September 30, 2021 and December 31, 2020, there were 9,055,489 and 6,869,189, respectively, shares of common stock reserved for the exercise of outstanding stock options and warrants. September 30, December 31, Stock options 8,215,549 6,112,948 Restricted stock units 800,466 716,767 Warrants 39,474 39,474 9,055,489 6,869,189 |
Stock options
Stock options | 9 Months Ended |
Sep. 30, 2021 | |
Share-based Payment Arrangement [Abstract] | |
Stock options | Stock options Stock option plans As of June 30, 2017, there were 3,141,625 stock options outstanding under the Company’s 2007 Stock Incentive Plan (the 2007 Plan). The 2007 Plan expired in June 2017. Any cancellations under the 2007 Stock Incentive Plan will increase the options available under the 2017 Stock Incentive Plan as described below. In June 2017, the Company’s stockholders approved the 2017 Stock Incentive Plan (the 2017 Plan). Under the 2017 Plan initially, up to 2,255,000 shares of common stock may be granted to the Company's employees, officers, directors, consultants and advisors in the form of options, restricted stock units (RSUs) or other stock-based awards. The number of shares of common stock issuable under the 2017 Plan will be cumulatively increased annually by 4% of the outstanding shares or such lesser amount specified by the Board. The terms of the awards are determined by the Board, subject to the provisions of the 2017 Plan. Any cancellations under the 2007 Plan, which expired in June 2017, would increase the number of shares that could be granted under the 2017 Plan. In January 2021, the number of shares of common stock issuable under the 2017 Plan was increased by 2,753,651 shares. As of September 30, 2021, there were 1,335,946 shares available for future issuance under the 2017 Plan. During the nine months ended September 30, 2021, the Company granted 3,396,186 RSUs and options to purchase shares of common stock to employees under the 2017 Plan. Under the 2017 Plan, both with respect to incentive stock options and nonqualified stock options, the exercise price per share will not be less than the fair market value of the common stock on the date of grant and the vesting period is generally four years. Options granted under the 2017 Plan expire no later than 10 years from the date of grant. Options under the 2007 Plan were granted at an exercise price established by the Board (or a committee thereof) that was not less than the fair market value of the underlying common stock on the date of grant and subject to such vesting provisions determined by the Board (or a committee thereof). The Board may accelerate vesting or otherwise adjust the terms of granted options in the case of a merger, consolidation, dissolution, or liquidation of the Company. Inducement awards The Company grants to its employees, upon approval by the Board, options to purchase shares of common stock as an inducement to employment in accordance with Nasdaq Listing Rule 5635(c)(4). The securities are issued pursuant to Section 4(a)(2) under the Securities Act of 1933, as amended, relating to transactions by an issuer not involving any public offering. These options are subject to terms substantially the same as the 2017 Plan. As of September 30, 2021 there were 532,500 options to purchase shares of common stock granted as inducement awards outstanding. Stock option activity A summary of stock option activity is as follows: Number Weighted- Outstanding at January 1, 2021 6,112,948 $ 7.84 Granted 2,957,970 17.73 Exercised (331,141) 4.70 Cancelled (524,228) 11.33 Outstanding at September 30, 2021 8,215,549 $ 11.31 Exercisable at September 30, 2021 3,731,070 $ 6.76 The weighted-average grant date fair value of options granted during the nine months ended September 30, 2021 and 2020, was $12.37 and $6.17 per share, respectively. Cash received from the exercise of stock options was $1,545 and $1,732 for the nine months ended September 30, 2021 and 2020, respectively. Restricted stock units (RSUs) The Company periodically issues RSUs with a service condition to certain officers and other employees that typically vest between one year and four years from the grant date. A summary of the RSU activity under the 2017 Plan is as follows: Number of Shares Unvested at January 1, 2021 716,767 Granted 650,716 Vested (400,836) Forfeited (166,181) Unvested at September 30, 2021 800,466 Stock-based compensation expense The Company uses the provisions of ASC 718, Stock Compensation , to account for all stock-based awards to employees and non-employees. The measurement date for employee awards is generally the date of grant. Stock-based compensation expense is recognized over the requisite service period, which is generally the vesting period, using the straight-line method. The following table presents stock-based compensation expense by award type included within the Company’s condensed consolidated statement of operations and comprehensive loss: Three Months Ended Nine Months Ended 2021 2020 2021 2020 Stock options $ 3,986 $ 1,520 $ 10,617 $ 4,025 Restricted stock units 881 335 2,636 962 Employee stock purchase plan 61 63 296 196 Stock-based compensation expense included in total operating expenses $ 4,928 $ 1,918 $ 13,549 $ 5,183 The following table presents stock-based compensation expense as reflected in the Company’s condensed consolidated statements of operations and comprehensive loss: Three Months Ended Nine Months Ended 2021 2020 2021 2020 Research and development $ 2,607 $ 952 $ 7,410 $ 2,554 General and administrative 2,321 966 6,139 2,629 Stock-based compensation expense included in total operating expenses $ 4,928 $ 1,918 $ 13,549 $ 5,183 As of September 30, 2021, there was $41,909 and $10,764 of unrecognized stock compensation expense related to unvested stock options and unvested RSUs, respectively, that is expected to be recognized over a weighted-average period of 2.8 years and 3.0 years, respectively. The fair value of each option award is estimated on the date of grant using the Black-Scholes option pricing model with the following weighted average assumptions: Three Months Ended Nine Months Ended 2021 2020 2021 2020 Risk-free interest rate 1.0 % 0.4 % 0.8 % 1.3 % Expected dividend yield — % — % — % — % Expected term (years) 6.11 6.10 6.05 6.04 Expected stock price volatility 82 % 81 % 83 % 72 % Expected volatility for the Company’s common stock is determined based on the historical volatility of comparable publicly traded companies. The risk-free interest rate is based on the yield of U.S. Treasury securities consistent with the expected term of the option. No dividend yield was assumed as the Company has not historically and does not expect to pay dividends on its common stock. The expected term of the options granted is based on the use of the simplified method, in which the expected term is presumed to be the mid-point between the vesting date and the end of the contractual term. The fair value of RSUs is determined based on the closing price of the Company’s common stock on the date of grant. |
Leases
Leases | 9 Months Ended |
Sep. 30, 2021 | |
Leases [Abstract] | |
Leases | Leases The Company has an operating lease for its office and lab space in Cambridge, MA and operating and finance leases for certain equipment. The operating lease for its office and lab space (the Office Lease) was amended in March 2020 and is effective through March 2026. The Company has an option to extend the lease term of the Office Lease for an additional five years. On April 5, 2021, the Company entered into an Eighth Amendment (the Expansion Agreement) to the Office Lease. The Expansion Agreement granted the Company additional office space in its existing building for five years, beginning July 1, 2021, committing to lease payments of $4,983 over that period (the Expansion Lease). In connection with the Expansion Lease, the Company increased the balance of the security deposit by increasing the standby letter of credit for the benefit of its landlord by $156. The Expansion Agreement also provides the Company with a tenant improvement allowance of $51. Independent from the option under the Office Lease, the Company has an option to extend the lease term of the Expansion Lease for an additional five years. The Company’s exercise of the options to extend the lease terms of both the Office Lease and Expansion Lease were not considered reasonably certain as of September 30, 2021. The Expansion Agreement is a lease modification that will be accounted for as a separate contract, because it expands the scope of the Office Lease and the additional lease payments are commensurate with market rents. The Company assessed the lease classification of the Expansion Lease as of the date of signing and determined that the Expansion Lease should be accounted for as an operating lease. The right-of-use asset and corresponding operating lease liability have been calculated based on the present value of lease payments over the lease term. The Company determined the appropriate incremental borrowing rate to utilize as a discount rate by using a synthetic credit rating which was estimated based on an analysis of outstanding debt of companies with similar credit and financial profiles. Since the operating lease is a net lease, as the non-lease components (i.e., common area maintenance) are paid separately from rent based on actual costs incurred, such non-lease components were not included in the right-of-use asset and liability and are reflected as an expense in the period incurred. As a result of the signing of the Expansion Agreement in April 2021, the Company recorded an increase of $3,783 to its right-of-use (ROU) asset and lease liabilities in the second quarter of 2021. The Company had a standby letter of credit agreement for the benefit of its landlord in the amount of $478 in connection with the Office Lease and Expansion Lease as of September 30, 2021 and $321 in connection with the Office Lease as of December 31, 2020, collateralized by a money market account. The Company has remaining finance lease terms of one year to five years for certain equipment, some of which include options to purchase at fair value. For the three and nine months ended September 30, 2021 the Company recorded assets under finance leases of $395 and $609, respectively, as property and equipment. The components of lease expense were as follows: Operating leases Finance leases 2021 (excluding the nine months ended September 30, 2021) $ 958 $ 76 2022 3,795 269 2023 3,909 262 2024 4,027 141 2025 and thereafter 5,457 56 Total lease payments 18,146 804 Present value adjustment (4,005) (49) Present value of lease liabilities $ 14,141 $ 755 |
Leases | Leases The Company has an operating lease for its office and lab space in Cambridge, MA and operating and finance leases for certain equipment. The operating lease for its office and lab space (the Office Lease) was amended in March 2020 and is effective through March 2026. The Company has an option to extend the lease term of the Office Lease for an additional five years. On April 5, 2021, the Company entered into an Eighth Amendment (the Expansion Agreement) to the Office Lease. The Expansion Agreement granted the Company additional office space in its existing building for five years, beginning July 1, 2021, committing to lease payments of $4,983 over that period (the Expansion Lease). In connection with the Expansion Lease, the Company increased the balance of the security deposit by increasing the standby letter of credit for the benefit of its landlord by $156. The Expansion Agreement also provides the Company with a tenant improvement allowance of $51. Independent from the option under the Office Lease, the Company has an option to extend the lease term of the Expansion Lease for an additional five years. The Company’s exercise of the options to extend the lease terms of both the Office Lease and Expansion Lease were not considered reasonably certain as of September 30, 2021. The Expansion Agreement is a lease modification that will be accounted for as a separate contract, because it expands the scope of the Office Lease and the additional lease payments are commensurate with market rents. The Company assessed the lease classification of the Expansion Lease as of the date of signing and determined that the Expansion Lease should be accounted for as an operating lease. The right-of-use asset and corresponding operating lease liability have been calculated based on the present value of lease payments over the lease term. The Company determined the appropriate incremental borrowing rate to utilize as a discount rate by using a synthetic credit rating which was estimated based on an analysis of outstanding debt of companies with similar credit and financial profiles. Since the operating lease is a net lease, as the non-lease components (i.e., common area maintenance) are paid separately from rent based on actual costs incurred, such non-lease components were not included in the right-of-use asset and liability and are reflected as an expense in the period incurred. As a result of the signing of the Expansion Agreement in April 2021, the Company recorded an increase of $3,783 to its right-of-use (ROU) asset and lease liabilities in the second quarter of 2021. The Company had a standby letter of credit agreement for the benefit of its landlord in the amount of $478 in connection with the Office Lease and Expansion Lease as of September 30, 2021 and $321 in connection with the Office Lease as of December 31, 2020, collateralized by a money market account. The Company has remaining finance lease terms of one year to five years for certain equipment, some of which include options to purchase at fair value. For the three and nine months ended September 30, 2021 the Company recorded assets under finance leases of $395 and $609, respectively, as property and equipment. The components of lease expense were as follows: Operating leases Finance leases 2021 (excluding the nine months ended September 30, 2021) $ 958 $ 76 2022 3,795 269 2023 3,909 262 2024 4,027 141 2025 and thereafter 5,457 56 Total lease payments 18,146 804 Present value adjustment (4,005) (49) Present value of lease liabilities $ 14,141 $ 755 |
Commitments
Commitments | 9 Months Ended |
Sep. 30, 2021 | |
Commitments and Contingencies Disclosure [Abstract] | |
Commitments | Commitments License agreements The Company recorded research and development expense of $1,225 and $2,125, respectively, for milestones during the three and nine months ended September 30, 2021. The Company is party to a license agreement with Recepta Biopharma S.A., or Recepta, for intellectual property covering the NaPi2b antibody in UpRi and XMT-1592 (as previously amended, the Recepta Agreement). In September 2021, the Company entered into a Second Amendment (the Recepta Amendment) pursuant to which the Company recorded research and development expense of $1,225 for milestones associated with UpRi. The Company recorded research and development expense of $250 and $750 for upfront payments and milestone payments, respectively, during the three and nine months ended September 30, 2020. See Note 9 for the Company’s future obligations related to leases as of September 30, 2021. |
Subsequent Events
Subsequent Events | 9 Months Ended |
Sep. 30, 2021 | |
Subsequent Events [Abstract] | |
Subsequent Events | Subsequent EventsOn October 29, 2021, the Company entered into a Loan and Security Agreement (the New Credit Facility) with Oxford Finance LLC as the collateral agent and a lender, and SVB as a lender (the “Lenders”). The New Credit Facility provides in aggregate up to $100,000, which includes $60,000 available immediately, $20,000 in two tranches of $10,000 each that are subject to meeting certain development milestones, and an additional tranche of $20,000, which is subject to conditional approval from the Lenders. Upon the closing date, the Company was funded $25,000, of which $5,500 was used to repay in full the existing obligations to SVB under the prior term loan agreement. The term loan will bear interest at 5.25% plus an index rate calculated as the greater of the prime rate and 3.25% (8.5%, floor). Interest is payable monthly in arrears on the first day of each month. The Company may make interest-only payments through November 1, 2024, followed by equal monthly principal payments and applicable interest through the maturity date of October 1, 2026. If certain development milestones are met, then the interest-only period will be extended to November 1, 2025. The Company is also required to make a final payment to the Lenders equal to 4.25% of the original principal amount of any funded term loan tranche then extended to the Company. The Company may elect to prepay all or part of the outstanding term loan, subject to a prepayment fee. |
Summary of Significant Accoun_2
Summary of Significant Accounting Policies (Policies) | 9 Months Ended |
Sep. 30, 2021 | |
Accounting Policies [Abstract] | |
Principles of Consolidation | Principles of Consolidation The accompanying unaudited condensed consolidated financial statements include those of the Company and its wholly owned subsidiary, Mersana Securities Corp. All intercompany balances and transactions have been eliminated. |
Use of Estimates | Use of Estimates The preparation of the Company’s unaudited condensed consolidated financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the reported amounts of assets, liabilities, equity, revenue, expenses and related disclosure of contingent assets and liabilities at the date of the financial statements and reported amounts of revenue and expenses during the reporting period. On an ongoing basis, the Company’s management evaluates its estimates which include, but are not limited to, management’s judgments with respect to the identification of performance obligations and standalone selling prices of those performance obligations within its revenue arrangements, accrued preclinical, manufacturing and clinical expenses, valuation of stock-based awards and income taxes. Actual results could differ from those estimates. |
Segment Information | Segment Information Operating segments are defined as components of an enterprise about which separate discrete information is available for evaluation by the chief operating decision-maker, or decision making group, in deciding how to allocate resources and assess performance. The Company views its operations and manages its business as a single operating segment, which is the business of discovering and developing ADCs. |
Fair Value Measurements | Fair Value Measurements Fair value is defined as the price that would be received upon sale of an asset or paid to transfer a liability between market participants at measurement dates. ASC Topic 820 Fair Value Measurement (ASC 820) establishes a three-level valuation hierarchy for instruments measured at fair value. The hierarchy is based on the transparency of inputs to the valuation of an asset or liability as of the measurement date. The three levels are defined as follows: Level 1—Inputs to the valuation methodology are quoted prices (unadjusted) for identical assets or liabilities in active markets. Level 2—Inputs to the valuation methodology include quoted prices for similar assets and liabilities in active markets, and inputs that are observable for the asset or liability, either directly or indirectly, for substantially the full term of the financial instrument. Level 3—Inputs to the valuation methodology are unobservable and significant to the fair value measurement. |
Cash and Cash Equivalents | Cash and Cash Equivalents The Company considers all highly-liquid investments with an original maturity, or a remaining maturity at the time of purchase, of three months or less to be cash equivalents. The Company invests excess cash primarily in money market funds, commercial paper and government agency securities, which are highly liquid and have strong credit ratings. These investments are subject to minimal credit and market risks. Cash and cash equivalents are stated at cost, which approximates market value. |
Other Assets | Other AssetsThe Company recorded other assets of $2,928 and $2,153 as of September 30, 2021 and December 31, 2020, respectively, comprised of $2,450 and $1,832, respectively, held by a service provider, and restricted cash of $478 and $321, respectively, held as a security deposit for a standby letter of credit related to a facility lease. |
Net Loss per Share | Net Loss per Share Basic net loss per share of common stock is calculated by dividing the net loss attributable to common stockholders by the weighted-average number of shares of common stock outstanding during the period, without further consideration for potentially dilutive securities. Diluted net loss per share is computed by dividing the net loss attributable to common stockholders by the weighted-average number of shares of common stock and potentially dilutive securities outstanding for the period determined using the treasury stock method. |
Recently Issued Accounting Pronouncements | Recently Issued Accounting Pronouncements In December 2019, the FASB issued ASU No. 2019-12, Income Taxes (Topic 740): Simplifying the Accounting for Income Taxes , as part of its initiative to reduce complexity in the accounting standards. The amendments in ASU 2019-12 eliminate certain exceptions related to the approach for intraperiod tax allocation, the methodology for calculating income taxes in an interim period and the recognition of deferred tax liabilities for outside basis differences. ASU 2019-12 also clarifies and simplifies other aspects of the accounting for income taxes. The amendments in ASU 2019-12 are effective for the fiscal years beginning after December 15, 2020. The adoption of ASU 2019-12 did not have a material effect on the Company's results of operations and financial position. |
Summary of Significant Accoun_3
Summary of Significant Accounting Policies (Tables) | 9 Months Ended |
Sep. 30, 2021 | |
Accounting Policies [Abstract] | |
Schedule of Cash and Cash Equivalents | Nine Months Ended Nine Months Ended Beginning End Beginning End Cash and cash equivalents $ 255,094 $ 191,707 $ 62,351 $ 270,936 Restricted cash included in other assets, noncurrent 321 478 321 321 Total cash, cash equivalents and restricted cash per statement of cash flows $ 255,415 $ 192,185 $ 62,672 $ 271,257 |
Schedule of Restricted Cash | Nine Months Ended Nine Months Ended Beginning End Beginning End Cash and cash equivalents $ 255,094 $ 191,707 $ 62,351 $ 270,936 Restricted cash included in other assets, noncurrent 321 478 321 321 Total cash, cash equivalents and restricted cash per statement of cash flows $ 255,415 $ 192,185 $ 62,672 $ 271,257 |
Schedule of Outstanding Potentially Dilutive Securities Excluded from Calculation of Diluted Net Loss per Share | The following table sets forth the outstanding potentially dilutive securities that have been excluded from the calculation of diluted net loss per share because to include them would be anti-dilutive (in common stock equivalent shares): Three and Nine Months Ended Three and Nine Months Ended Stock options 8,215,549 6,215,368 Unvested restricted stock units 800,466 740,862 Warrants 39,474 39,474 9,055,489 6,995,704 |
Collaboration Agreements (Table
Collaboration Agreements (Tables) | 9 Months Ended |
Sep. 30, 2021 | |
Collaboration agreements | |
Schedule of Changes in the Balance of Our Contract Assets and Liabilities and Recognized Revenue | The following table presents changes in the balances of the Company's contract assets and liabilities during the nine months ended September 30, 2021 and 2020: Balance at Additions Deductions Balance at Nine months ended September 30, 2021 Contract assets $ — $ — $ — $ — Contract liabilities: Deferred revenue $ 3,987 $ — $ 32 $ 3,955 Balance at Additions Deductions Balance at Nine months ended September 30, 2020 Contract assets $ — $ — $ — $ — Contract liabilities: Deferred revenue $ 4,815 $ — $ 817 $ 3,998 During the three and nine months ended September 30, 2021 and 2020, the Company recognized the following revenues as a result of changes in the contract asset and the contract liability balances in the respective periods: Three Months Ended Nine Months Ended 2021 2020 2021 2020 Revenue recognized in the period from: Amounts included in the contract liability at the beginning of the period $ 11 $ 11 $ 32 $ 817 Performance obligations satisfied in previous periods $ — $ — $ — $ — |
Accrued expenses (Tables)
Accrued expenses (Tables) | 9 Months Ended |
Sep. 30, 2021 | |
Accrued Liabilities, Current [Abstract] | |
Schedule of Accrued Expenses | Accrued expenses consisted of the following as of September 30, 2021 and December 31, 2020: September 30, December 31, Accrued clinical expenses $ 12,057 $ 5,126 Accrued manufacturing expenses 8,951 4,157 Accrued preclinical expenses 2,864 619 Accrued payroll and related expenses 6,285 5,412 Accrued professional fees 1,449 757 Accrued other 109 75 $ 31,715 $ 16,146 |
Debt (Tables)
Debt (Tables) | 9 Months Ended |
Sep. 30, 2021 | |
Debt Disclosure [Abstract] | |
Schedule of Debt | As of September 30, 2021, the Company had drawn a term loan of $5,200, and debt consisted of the following: September 30, Total debt $ 5,200 Less: Current portion of long-term-debt — Total debt, net of current portion 5,200 Debt financing costs, net of accretion (197) Accretion related to final payment 74 Long-term debt, net $ 5,077 |
Schedule of Estimated Future Payments | As of September 30, 2021, the estimated future principal payments due are as follows: 2021 (excluding the nine months ended September 30, 2021) $ — 2022 1,213 2023 2,080 2024 1,907 Total debt $ 5,200 |
Stockholders' equity (Tables)
Stockholders' equity (Tables) | 9 Months Ended |
Sep. 30, 2021 | |
Stockholders' Equity Note [Abstract] | |
Schedule for Number of Common Stock Reserved for Exercise of Outstanding Stock Options and Warrants | At September 30, 2021 and December 31, 2020, there were 9,055,489 and 6,869,189, respectively, shares of common stock reserved for the exercise of outstanding stock options and warrants. September 30, December 31, Stock options 8,215,549 6,112,948 Restricted stock units 800,466 716,767 Warrants 39,474 39,474 9,055,489 6,869,189 |
Stock options (Tables)
Stock options (Tables) | 9 Months Ended |
Sep. 30, 2021 | |
Share-based Payment Arrangement [Abstract] | |
Schedule of Stock Option Activity Under Plan | A summary of stock option activity is as follows: Number Weighted- Outstanding at January 1, 2021 6,112,948 $ 7.84 Granted 2,957,970 17.73 Exercised (331,141) 4.70 Cancelled (524,228) 11.33 Outstanding at September 30, 2021 8,215,549 $ 11.31 Exercisable at September 30, 2021 3,731,070 $ 6.76 |
Schedule of Restricted Stock Activity | A summary of the RSU activity under the 2017 Plan is as follows: Number of Shares Unvested at January 1, 2021 716,767 Granted 650,716 Vested (400,836) Forfeited (166,181) Unvested at September 30, 2021 800,466 |
Schedule of Stock-Based Compensation Expense by Award Type | The following table presents stock-based compensation expense by award type included within the Company’s condensed consolidated statement of operations and comprehensive loss: Three Months Ended Nine Months Ended 2021 2020 2021 2020 Stock options $ 3,986 $ 1,520 $ 10,617 $ 4,025 Restricted stock units 881 335 2,636 962 Employee stock purchase plan 61 63 296 196 Stock-based compensation expense included in total operating expenses $ 4,928 $ 1,918 $ 13,549 $ 5,183 |
Schedule of Stock-Based Compensation Expense as Reflected in the Company's Condensed Consolidated Statements of Operations and Comprehensive Loss | The following table presents stock-based compensation expense as reflected in the Company’s condensed consolidated statements of operations and comprehensive loss: Three Months Ended Nine Months Ended 2021 2020 2021 2020 Research and development $ 2,607 $ 952 $ 7,410 $ 2,554 General and administrative 2,321 966 6,139 2,629 Stock-based compensation expense included in total operating expenses $ 4,928 $ 1,918 $ 13,549 $ 5,183 |
Schedule of Weighted Average Assumptions for Estimating Fair Value of Option Awards | The fair value of each option award is estimated on the date of grant using the Black-Scholes option pricing model with the following weighted average assumptions: Three Months Ended Nine Months Ended 2021 2020 2021 2020 Risk-free interest rate 1.0 % 0.4 % 0.8 % 1.3 % Expected dividend yield — % — % — % — % Expected term (years) 6.11 6.10 6.05 6.04 Expected stock price volatility 82 % 81 % 83 % 72 % |
Leases (Tables)
Leases (Tables) | 9 Months Ended |
Sep. 30, 2021 | |
Leases [Abstract] | |
Schedule of Future Minimum Payments Under Operating Leases | The components of lease expense were as follows: Operating leases Finance leases 2021 (excluding the nine months ended September 30, 2021) $ 958 $ 76 2022 3,795 269 2023 3,909 262 2024 4,027 141 2025 and thereafter 5,457 56 Total lease payments 18,146 804 Present value adjustment (4,005) (49) Present value of lease liabilities $ 14,141 $ 755 |
Schedule of Future Minimum Payments Under Finance Leases | The components of lease expense were as follows: Operating leases Finance leases 2021 (excluding the nine months ended September 30, 2021) $ 958 $ 76 2022 3,795 269 2023 3,909 262 2024 4,027 141 2025 and thereafter 5,457 56 Total lease payments 18,146 804 Present value adjustment (4,005) (49) Present value of lease liabilities $ 14,141 $ 755 |
Nature of business and basis _2
Nature of business and basis of presentation - (Details) - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended | |||||||
Sep. 30, 2021 | Jun. 30, 2021 | Mar. 31, 2021 | Dec. 31, 2020 | Sep. 30, 2020 | Jun. 30, 2020 | Mar. 31, 2020 | Sep. 30, 2021 | Sep. 30, 2020 | |
Organization, Consolidation and Presentation of Financial Statements [Abstract] | |||||||||
Net loss | $ 45,471 | $ 40,913 | $ 34,693 | $ 28,844 | $ 22,489 | $ 19,786 | $ 16,926 | $ 121,077 | $ 59,203 |
Accumulated deficit | $ (401,496) | $ (280,419) | $ (401,496) |
Summary of significant accoun_4
Summary of significant accounting policies - Cash and Cash Equivalents (Details) - USD ($) $ in Thousands | Sep. 30, 2021 | Dec. 31, 2020 | Sep. 30, 2020 | Dec. 31, 2019 |
Cash, cash equivalents and restricted cash | ||||
Cash and cash equivalents | $ 191,707 | $ 255,094 | $ 270,936 | $ 62,351 |
Restricted cash included in other assets, noncurrent | 478 | 321 | 321 | 321 |
Total cash, cash equivalents and restricted cash per statement of cash flows | $ 192,185 | $ 255,415 | $ 271,257 | $ 62,672 |
Summary of significant accoun_5
Summary of significant accounting policies - Other Assets (Details) - USD ($) $ in Thousands | Sep. 30, 2021 | Dec. 31, 2020 |
Other Assets | ||
Other assets | $ 2,928 | $ 2,153 |
Held by service provider | 2,450 | 1,832 |
Security deposit | $ 478 | $ 321 |
Summary of significant accoun_6
Summary of significant accounting policies - Net loss per share (Details) - shares | 3 Months Ended | 9 Months Ended | ||
Sep. 30, 2021 | Sep. 30, 2020 | Sep. 30, 2021 | Sep. 30, 2020 | |
Anti-dilutive securities | ||||
Anti-dilutive securities (in shares) | 9,055,489 | 6,995,704 | 9,055,489 | 6,995,704 |
Stock options | ||||
Anti-dilutive securities | ||||
Anti-dilutive securities (in shares) | 8,215,549 | 6,215,368 | 8,215,549 | 6,215,368 |
Restricted stock units | ||||
Anti-dilutive securities | ||||
Anti-dilutive securities (in shares) | 800,466 | 740,862 | 800,466 | 740,862 |
Warrants | ||||
Anti-dilutive securities | ||||
Anti-dilutive securities (in shares) | 39,474 | 39,474 | 39,474 | 39,474 |
Collaboration agreements - Merc
Collaboration agreements - Merck KGaA (Details) - Merck KGaA | 1 Months Ended | ||
Jun. 30, 2014USD ($)target | Sep. 30, 2021USD ($)target | Dec. 31, 2017target | |
Collaboration agreements | |||
Upfront payment received | $ 12,000,000 | ||
Number of targets | target | 6 | ||
Amount of additional fees receivable when target is designated and commercial license to target is granted | $ 0 | ||
Number of targets designated | target | 6 | 6 | |
Next potential development milestone payment eligible to receive | $ 500,000 |
Collaboration agreements - Me_2
Collaboration agreements - Merck KGaA - Accounting Analysis (Details) $ in Thousands | 3 Months Ended | 9 Months Ended | ||||
Sep. 30, 2021USD ($) | Sep. 30, 2020USD ($) | Sep. 30, 2021USD ($)target | Sep. 30, 2020USD ($) | Dec. 31, 2020USD ($) | Dec. 31, 2019USD ($) | |
Collaboration agreements | ||||||
Collaboration revenue | $ 11 | $ 11 | $ 32 | $ 817 | ||
Deferred revenue | 3,955 | 3,998 | 3,955 | 3,998 | $ 3,987 | $ 4,815 |
Merck KGaA Agreement and Merck KGaA Supply Agreement | ||||||
Collaboration agreements | ||||||
Deferred revenue | 3,955 | $ 3,955 | $ 3,987 | |||
Merck KGaA | ||||||
Collaboration agreements | ||||||
Number of targets with satisfied performance obligations | target | 4 | |||||
Collaboration revenue | 11 | 11 | $ 32 | 817 | ||
Merck KGaA Supply Agreement | ||||||
Collaboration agreements | ||||||
Collaboration revenue | $ 0 | $ 0 | $ 0 | $ 0 | ||
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2021-10-01 | Merck KGaA | Rights to future technological improvements | ||||||
Collaboration agreements | ||||||
Expected recognition period | 10 years | 10 years | ||||
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2021-10-01 | Merck KGaA | Joint research committee services | ||||||
Collaboration agreements | ||||||
Expected recognition period | 5 years | 5 years |
Collaboration Agreements - Cont
Collaboration Agreements - Contract Assets and Liabilities (Details) - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended | ||||
Sep. 30, 2021 | Sep. 30, 2020 | Sep. 30, 2021 | Sep. 30, 2020 | Dec. 31, 2020 | Dec. 31, 2019 | |
Collaboration agreements | ||||||
Contract assets | $ 0 | $ 0 | $ 0 | $ 0 | $ 0 | $ 0 |
Contract liabilities | ||||||
Deferred revenue beginning balance | 3,987 | 4,815 | ||||
Deferred revenue, Additions | 0 | 0 | ||||
Deferred revenue, Deductions | 32 | 817 | ||||
Deferred revenue ending balance | 3,955 | 3,998 | 3,955 | 3,998 | ||
Revenue recognized in the period from: | ||||||
Amounts included in the contract liability at the beginning of the period | 11 | 11 | 32 | 817 | ||
Performance obligations satisfied in previous periods | $ 0 | $ 0 | $ 0 | $ 0 |
Collaboration Agreements - Othe
Collaboration Agreements - Other Revenue (Details) - USD ($) | 3 Months Ended | 9 Months Ended | ||
Sep. 30, 2021 | Sep. 30, 2020 | Sep. 30, 2021 | Sep. 30, 2020 | |
Collaboration agreements | ||||
Collaboration revenue | $ 11,000 | $ 11,000 | $ 32,000 | $ 817,000 |
Asana BioSciences | ||||
Collaboration agreements | ||||
Next potential milestone payment eligible to receive | $ 2,500,000 | 2,500,000 | ||
Asana BioSciences | Limited services | ||||
Collaboration agreements | ||||
Collaboration revenue | $ 0 | $ 0 |
Accrued expenses (Details)
Accrued expenses (Details) - USD ($) $ in Thousands | Sep. 30, 2021 | Dec. 31, 2020 |
Accrued Liabilities, Current [Abstract] | ||
Accrued clinical expenses | $ 12,057 | $ 5,126 |
Accrued manufacturing expenses | 8,951 | 4,157 |
Accrued preclinical expenses | 2,864 | 619 |
Accrued payroll and related expenses | 6,285 | 5,412 |
Accrued professional fees | 1,449 | 757 |
Accrued other | 109 | 75 |
Total | $ 31,715 | $ 16,146 |
Debt - Agreement Narrative (Det
Debt - Agreement Narrative (Details) - USD ($) | 3 Months Ended | 9 Months Ended | ||||
Sep. 30, 2021 | Sep. 30, 2020 | Sep. 30, 2021 | Sep. 30, 2020 | Aug. 27, 2021 | Aug. 28, 2020 | |
Debt | ||||||
Outstanding debt | $ 5,200,000 | $ 5,200,000 | ||||
Interest expense | 90,000 | $ 60,000 | 267,000 | $ 173,000 | ||
Amendment To Credit Facility | Line of Credit | ||||||
Debt | ||||||
Maximum borrowing capacity | $ 30,000,000 | |||||
Outstanding debt | $ 5,200,000 | $ 5,200,000 | ||||
Amended Credit Facility, Tranche One | Line of Credit | ||||||
Debt | ||||||
Maximum borrowing capacity | 25,000,000 | |||||
Amended Credit Facility, Tranche Two | Line of Credit | ||||||
Debt | ||||||
Maximum borrowing capacity | 25,000,000 | |||||
Amended Credit Facility, Tranche Three | Line of Credit | ||||||
Debt | ||||||
Maximum borrowing capacity | 25,000,000 | |||||
Amended Credit Facility, Tranche Four | Line of Credit | ||||||
Debt | ||||||
Maximum borrowing capacity | 25,000,000 | |||||
Amended Credit Facility, Tranche Five | Line of Credit | ||||||
Debt | ||||||
Maximum borrowing capacity | 25,000,000 | |||||
Amended Credit Facility, Tranche Six | Line of Credit | ||||||
Debt | ||||||
Line of credit, increase limit | $ 5,000,000 | $ 5,000,000 |
Debt - Components (Details)
Debt - Components (Details) - USD ($) $ in Thousands | Sep. 30, 2021 | Dec. 31, 2020 |
Debt Disclosure [Abstract] | ||
Outstanding debt | $ 5,200 | |
Less: Current portion of long-term-debt | 0 | |
Long-term debt, net | 5,200 | |
Debt financing costs, net of accretion | (197) | |
Accretion related to final payment | 74 | |
Long-term debt, net | $ 5,077 | $ 4,977 |
Debt - Future payments (Details
Debt - Future payments (Details) $ in Thousands | Sep. 30, 2021USD ($) |
Estimated future principal payments | |
2021 (excluding the nine months ended September 30, 2021) | $ 0 |
2022 | 1,213 |
2023 | 2,080 |
2024 | 1,907 |
Total debt | $ 5,200 |
Stockholders' Equity - Preferre
Stockholders' Equity - Preferred stock (Details) - shares | Sep. 30, 2021 | Dec. 31, 2020 |
Stockholders' Equity Note [Abstract] | ||
Preferred stock, shares authorized (in shares) | 25,000,000 | 25,000,000 |
Preferred stock, shares issued (in shares) | 0 | 0 |
Stockholders' Equity - At-the-m
Stockholders' Equity - At-the-market equity and follow on offering programs (Details) - USD ($) | 1 Months Ended | 9 Months Ended | |||
Jun. 30, 2020 | Apr. 30, 2020 | Sep. 30, 2021 | May 31, 2020 | Jul. 31, 2018 | |
2018 ATM | |||||
Offering program | |||||
Amount of shares authorized to be offered and sold | $ 75,000,000 | ||||
Proceeds from issuance of common stock, gross | $ 65,153,000 | ||||
Proceeds from stock issuance, net of issuance costs | $ 62,976,000 | ||||
At Market Equity Offering Program, 5.59 per Share | |||||
Offering program | |||||
Number of shares sold (in shares) | 8,938,599 | ||||
Shares sold, price per share (in dollars per share) | $ 5.59 | ||||
At Market Equity Offering Program, 7.74 per Share | |||||
Offering program | |||||
Number of shares sold (in shares) | 1,962,000 | ||||
Shares sold, price per share (in dollars per share) | $ 7.74 | ||||
2020 ATM | |||||
Offering program | |||||
Amount of shares authorized to be offered and sold | $ 100,000,000 | ||||
Number of shares sold (in shares) | 2,271,074 | ||||
Shares sold, price per share (in dollars per share) | $ 14.99 | ||||
Proceeds from issuance of common stock, gross | $ 34,033,000 | ||||
Proceeds from stock issuance, net of issuance costs | $ 33,287,000 | ||||
Public Stock Offering | |||||
Offering program | |||||
Number of shares sold (in shares) | 9,200,000 | ||||
Shares sold, price per share (in dollars per share) | $ 19 | ||||
Proceeds from stock issuance, net of issuance costs | $ 163,990,000 |
Stockholders' Equity - Warrants
Stockholders' Equity - Warrants (Details) - $ / shares | 12 Months Ended | |
Dec. 31, 2013 | Sep. 30, 2021 | |
Warrants | ||
Number of shares into which warrant issued during period may be converted (in shares) | 129,491 | |
Warrant exercise price per share (in dollars per share) | $ 0.05 | |
Contractual life of warrants | 10 years | |
Number of shares of common stock into which warrants may be converted (in shares) | 39,474 |
Stockholders' Equity - Exchange
Stockholders' Equity - Exchange Warrants (Details) - $ / shares | Mar. 02, 2020 | Nov. 26, 2019 | Sep. 30, 2021 | Dec. 31, 2013 |
Class of Stock [Line Items] | ||||
Warrant exercise price per share (in dollars per share) | $ 0.05 | |||
Number of shares of common stock into which warrants may be converted (in shares) | 39,474 | |||
Common Stock | ||||
Class of Stock [Line Items] | ||||
Exercise of common stock warrant in exchange for common stock (in shares) | 2,574,971 | 0 | ||
Warrant Two | ||||
Class of Stock [Line Items] | ||||
Warrant exercise price per share (in dollars per share) | $ 0.0001 | |||
Number of shares of common stock into which warrants may be converted (in shares) | 2,575,000 | |||
Aggregate common stock exchanged (in shares) | 2,575,000 |
Stockholders' Equity - Common s
Stockholders' Equity - Common stock (Details) - shares | 9 Months Ended | |
Sep. 30, 2021 | Dec. 31, 2020 | |
Common stock | ||
Common stock voting rights | The holders of the common stock are entitled to one vote for each share held. | |
Number of shares reserved for future issuance (in shares) | 9,055,489 | 6,869,189 |
Share-based payments | Stock options | ||
Common stock | ||
Number of shares reserved for future issuance (in shares) | 8,215,549 | 6,112,948 |
Share-based payments | Restricted stock units | ||
Common stock | ||
Number of shares reserved for future issuance (in shares) | 800,466 | 716,767 |
Warrants | ||
Common stock | ||
Number of shares reserved for future issuance (in shares) | 39,474 | 39,474 |
Stock options - Plans narrative
Stock options - Plans narrative (Details) - shares | 1 Months Ended | 9 Months Ended | ||
Jan. 31, 2021 | Jun. 30, 2017 | Sep. 30, 2021 | Dec. 31, 2020 | |
Stock options | ||||
Number of shares outstanding (in shares) | 8,215,549 | 6,112,948 | ||
Stock options | ||||
Stock options | ||||
Vesting period | 4 years | |||
2007 Plan | ||||
Stock options | ||||
Number of shares outstanding (in shares) | 3,141,625 | |||
2017 Plan | ||||
Stock options | ||||
Number of shares authorized (in shares) | 2,255,000 | |||
Cumulative annual increase in number of shares issuable | 4.00% | |||
Additional shares authorized (in shares) | 2,753,651 | |||
Number of shares available for future issuance (in shares) | 1,335,946 | |||
Number of options granted in period (in shares) | 3,396,186 | |||
2017 Plan | Maximum | ||||
Stock options | ||||
Expiration period | 10 years | |||
Inducement Award Program | ||||
Stock options | ||||
Number of shares outstanding (in shares) | 532,500 |
Stock options - Inducement awar
Stock options - Inducement awards narrative (Details) - shares | Sep. 30, 2021 | Dec. 31, 2020 |
Stock options | ||
Number of shares outstanding (in shares) | 8,215,549 | 6,112,948 |
Inducement Award Program | ||
Stock options | ||
Number of shares outstanding (in shares) | 532,500 |
Stock options - Activity under
Stock options - Activity under stock option plan (Details) $ / shares in Units, $ in Thousands | 9 Months Ended | |
Sep. 30, 2021USD ($)$ / sharesshares | Sep. 30, 2020USD ($)$ / shares | |
Number of Shares | ||
Outstanding at beginning of period (in shares) | shares | 6,112,948 | |
Granted (in shares) | shares | 2,957,970 | |
Exercised (in shares) | shares | (331,141) | |
Cancelled (in shares) | shares | (524,228) | |
Outstanding at end of period (in shares) | shares | 8,215,549 | |
Options exercisable, at end of period (in shares) | shares | 3,731,070 | |
Weighted- Average Exercise Price | ||
Outstanding at beginning of period (in dollars per share) | $ 7.84 | |
Granted (in dollars per share) | 17.73 | |
Exercised (in dollars per share) | 4.70 | |
Cancelled (in dollars per share) | 11.33 | |
Outstanding at end of period (in dollars per share) | 11.31 | |
Options exercisable, at end of period (in dollars per share) | 6.76 | |
Additional Disclosures | ||
Weighted-average grant date fair value of options granted (in dollars per share) | $ 12.37 | $ 6.17 |
Cash received from the exercise of stock options | $ | $ 1,545 | $ 1,732 |
Stock options - Restricted stoc
Stock options - Restricted stock units (Details) - Restricted stock units - shares | 3 Months Ended | 9 Months Ended |
Sep. 30, 2021 | Sep. 30, 2021 | |
Restricted stock units | ||
Unvested at beginning of period (in shares) | 716,767 | |
Granted (in shares) | 650,716 | |
Vested (in shares) | (400,836) | |
Forfeited (in shares) | (166,181) | |
Unvested at end of period (in shares) | 800,466 | 800,466 |
Minimum | ||
Stock options | ||
Vesting period | 1 year | |
Maximum | ||
Stock options | ||
Vesting period | 4 years |
Stock options - Stock based com
Stock options - Stock based compensation expense (Details) - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended | ||
Sep. 30, 2021 | Sep. 30, 2020 | Sep. 30, 2021 | Sep. 30, 2020 | |
Stock options | ||||
Stock-based compensation expense included in total operating expenses | $ 4,928 | $ 1,918 | $ 13,549 | $ 5,183 |
Research and development | ||||
Stock options | ||||
Stock-based compensation expense included in total operating expenses | 2,607 | 952 | 7,410 | 2,554 |
General and administrative | ||||
Stock options | ||||
Stock-based compensation expense included in total operating expenses | 2,321 | 966 | 6,139 | 2,629 |
Stock options | ||||
Stock options | ||||
Stock-based compensation expense included in total operating expenses | 3,986 | 1,520 | 10,617 | 4,025 |
Unrecognized stock compensation cost | 41,909 | $ 41,909 | ||
Weighted-average amortization period of unrecognized stock compensation cost | 2 years 9 months 18 days | |||
Restricted stock units | ||||
Stock options | ||||
Stock-based compensation expense included in total operating expenses | 881 | 335 | $ 2,636 | 962 |
Unrecognized stock compensation cost | 10,764 | $ 10,764 | ||
Weighted-average amortization period of unrecognized stock compensation cost | 3 years | |||
Employee stock purchase plan | ||||
Stock options | ||||
Stock-based compensation expense included in total operating expenses | $ 61 | $ 63 | $ 296 | $ 196 |
Stock options - Fair value assu
Stock options - Fair value assumptions (Details) | 3 Months Ended | 9 Months Ended | ||
Sep. 30, 2021 | Sep. 30, 2020 | Sep. 30, 2021 | Sep. 30, 2020 | |
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions and Methodology [Abstract] | ||||
Risk-free interest rate | 1.00% | 0.40% | 0.80% | 1.30% |
Expected dividend yield | 0.00% | 0.00% | 0.00% | 0.00% |
Expected term (years) | 6 years 1 month 9 days | 6 years 1 month 6 days | 6 years 18 days | 6 years 14 days |
Expected stock price volatility | 82.00% | 81.00% | 83.00% | 72.00% |
Stock options - Employee stock
Stock options - Employee stock purchase plan narrative (Details) - shares | Jan. 01, 2020 | Sep. 30, 2021 | Sep. 30, 2020 | Sep. 30, 2021 | Sep. 30, 2020 | Dec. 31, 2020 | Dec. 31, 2017 |
Employee Stock Purchase Plan | |||||||
Number of shares reserved for future issuance (in shares) | 9,055,489 | 9,055,489 | 6,869,189 | ||||
Employee stock purchase plan | 2017 ESPP | |||||||
Employee Stock Purchase Plan | |||||||
Number of shares reserved for future issuance (in shares) | 225,000 | ||||||
Purchase of common stock under ESPP (in shares) | 36,198 | 68,419 | 36,198 | 68,419 | |||
Number of shares available for future issuance (in shares) | 608,620 | 608,620 | |||||
Additional shares authorized (in shares) | 450,000 |
Leases - Description (Details)
Leases - Description (Details) - USD ($) $ in Thousands | Apr. 05, 2021 | Sep. 30, 2021 | Jun. 30, 2021 | Sep. 30, 2021 | Sep. 30, 2020 | Dec. 31, 2020 |
Leases | ||||||
Lease liability | $ 14,141 | $ 14,141 | ||||
Security deposit | 478 | 478 | $ 321 | |||
Increase in right-of-use assets | $ 3,783 | |||||
Assets under finance leases | $ 395 | $ 609 | $ 0 | |||
Office space, Cambridge, MA | ||||||
Leases | ||||||
Lease expiration date | Mar. 31, 2026 | |||||
Renewal term | 5 years | 5 years | ||||
Office Space Expansion Cambridge Ma | ||||||
Leases | ||||||
Renewal term | 5 years | |||||
Lease term | 5 years | |||||
Lease liability | $ 4,983 | |||||
Security deposit | 156 | |||||
Tenant improvement allowance | $ 51 | |||||
Minimum | ||||||
Leases | ||||||
Finance lease, remaining lease term | 1 year | 1 year | ||||
Maximum | ||||||
Leases | ||||||
Finance lease, remaining lease term | 5 years | 5 years |
Leases - Future minimum lease p
Leases - Future minimum lease payments (Details) $ in Thousands | Sep. 30, 2021USD ($) |
Operating leases | |
2021 (excluding the nine months ended September 30, 2021) | $ 958 |
2022 | 3,795 |
2023 | 3,909 |
2024 | 4,027 |
2025 and thereafter | 5,457 |
Total lease payments | 18,146 |
Present value adjustment | (4,005) |
Present value of lease liabilities | 14,141 |
Finance leases | |
2021 (excluding the nine months ended September 30, 2021) | 76 |
2022 | 269 |
2023 | 262 |
2024 | 141 |
2025 and thereafter | 56 |
Total lease payments | 804 |
Present value adjustment | (49) |
Present value of lease liabilities | $ 755 |
Commitments - (Details)
Commitments - (Details) - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended | ||
Sep. 30, 2021 | Sep. 30, 2020 | Sep. 30, 2021 | Sep. 30, 2020 | |
License Agreement, Milestone Payments | ||||
Commitments | ||||
Research and development expense | $ 1,225 | $ 250 | $ 2,125 | $ 750 |
Subsequent Events (Details)
Subsequent Events (Details) - Subsequent Event - Line of Credit $ in Thousands | Oct. 29, 2021USD ($) |
New Credit Facility | |
Subsequent Event [Line Items] | |
Maximum borrowing capacity | $ 100,000 |
Repayments of debt | 5,500 |
Proceeds from issuance of debt | $ 25,000 |
Debt interest rate (as a percent) | 5.25% |
Interest rate index, maximum (as a percent) | 3.25% |
Commitment fee (as a percent) | 4.25% |
New Credit Facility, Tranche One | |
Subsequent Event [Line Items] | |
Maximum borrowing capacity | $ 60,000 |
New Credit Facility, Tranche Two and Three | |
Subsequent Event [Line Items] | |
Maximum borrowing capacity | 20,000 |
New Credit Facility, Tranche Two | |
Subsequent Event [Line Items] | |
Maximum borrowing capacity | 10,000 |
New Credit Facility, Tranche Three | |
Subsequent Event [Line Items] | |
Maximum borrowing capacity | 10,000 |
New Credit Facility, Tranche Four | |
Subsequent Event [Line Items] | |
Maximum borrowing capacity | $ 20,000 |