Exhibit 23.1
CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
We hereby consent to the incorporation by reference in this Registration Statement onForm S-3 of our report dated March 30, 2017 relating to the financial statements, which appears in Proteostasis Therapeutics, Inc.’s Annual Report on Form10-K for the year ended December 31, 2016. We also consent to the reference to us under the heading “Experts” in such Registration Statement.
/s/ PricewaterhouseCoopers LLP
Boston, Massachusetts
June 7, 2017
