Exhibit 23.1
CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
We hereby consent to the incorporation by reference in this Registration Statement on FormS-8 of Proteostasis Therapeutics, Inc., of our report dated March 8, 2019 relating to the financial statements, which appears in Proteostasis Therapeutics, Inc.’s Annual Report on Form10-K for the year ended December 31, 2018.
/s/ PricewaterhouseCoopers LLP
Boston, Massachusetts
March 8, 2019