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Exhibit 23.1
CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
We hereby consent to the incorporation by reference in the Registration Statements on Form S‑8 (No. 333-218544 and No. 333-210521) and Form S-3 (No. 333-218545) of Proteostasis Therapeutics, Inc. of our report dated March 14, 2018 relating to the financial statements, which appears in this Form 10K.
/s/ PricewaterhouseCoopers LLP
Boston, Massachusetts
March 14, 2018