Predictive Oncology (POAI) 8-K Changes in Registrant's Certifying Accountant

Exhibit 16.1

April 30, 2020

Securities and Exchange Commission

100 F Street, N.E.

Washington, D.C. 20549-7561

Dear Sirs/Madams:

We have read Item 4.01 of Predictive Oncology Inc.'s Form 8-K dated April 30, 2020, and we agree with the statements made therein.

Yours truly,

/s/ DELOITTE & TOUCHE LLP