Cognition Therapeutics (CGTX) 10-Q4 May 232023 Q1 Quarterly reportFinancial data

Company Profile

Document and Entity Information

Document and Entity Information - shares	3 Months Ended
Document and Entity Information - shares	Mar. 31, 2023	May 01, 2023
Document and Entity Information [Abstract]
Document Type	10-Q
Document Quarterly Report	true
Document Transition Report	false
Document Period End Date	Mar. 31, 2023
Entity File Number	001-40886
Entity Registrant Name	Cognition Therapeutics, Inc.
Entity Incorporation, State or Country Code	DE
Entity Tax Identification Number	13-4365359
Entity Address, Address Line One	2500 Westchester Ave.
Entity Address, City or Town	Purchase
Entity Address State Or Province	NY
Entity Address, Postal Zip Code	10577
City Area Code	412
Local Phone Number	481-2210
Title of 12(b) Security	Common Stock, par value $0.001 per share
Trading Symbol	CGTX
Security Exchange Name	NASDAQ
Entity Current Reporting Status	Yes
Entity Interactive Data Current	Yes
Entity Filer Category	Non-accelerated Filer
Entity Small Business	true
Entity Emerging Growth Company	true
Entity Ex Transition Period	false
Entity Shell Company	false
Entity Common Stock, Shares Outstanding		29,277,227
Entity Central Index Key	0001455365
Current Fiscal Year End Date	--12-31
Document Fiscal Year Focus	2023
Document Fiscal Period Focus	Q1
Amendment Flag	false

CONSOLIDATED BALANCE SHEETS

CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Mar. 31, 2023	Dec. 31, 2022
Current assets:
Cash and cash equivalents	$ 38,810	$ 41,562
Grant receivables	1,609	3,672
Prepaid expenses and other current assets	2,382	2,413
Total current assets	42,801	47,647
Property and equipment, net	253	233
Right-of-use assets, operating leases	774	813
Other assets	1,835	1,732
Total assets	45,663	50,425
Current liabilities:
Accounts payable	3,120	3,216
Accrued expenses	2,115	2,094
Deferred grant income, current	1,646	1,702
Operating lease liabilities, current	157	149
Other current liabilities	427	634
Total current liabilities	7,465	7,795
Operating lease liabilities, noncurrent	651	695
Deferred grant income and other liabilities, noncurrent	1,764	1,686
Total liabilities	9,880	10,176
Commitments and contingencies (Note 7)
Stockholders' equity:
Preferred stock, $0.001 par value, 10,000,000 shares authorized; no shares issued and outstanding at March 31, 2023 and December 31, 2022
Common stock, $0.001 par value, 250,000,000 shares authorized; 29,277,227 and 28,991,548 shares issued and outstanding at March 31, 2023 and December 31, 2022, respectively	29	29
Additional paid-in capital	157,522	155,820
Accumulated deficit	(121,573)	(115,401)
Accumulated other comprehensive loss	(195)	(199)
Total stockholders' equity	35,783	40,249
Total liabilities and stockholders' equity	$ 45,663	$ 50,425

CONSOLIDATED BALANCE SHEETS (Pa

CONSOLIDATED BALANCE SHEETS (Parenthetical) - $ / shares	Mar. 31, 2023	Dec. 31, 2022
CONSOLIDATED BALANCE SHEETS
Preferred stock, par value (in dollars per share)	$ 0.001	$ 0.001
Preferred stock shares authorized	10,000,000	10,000,000
Preferred stock, shares issued	0	0
Preferred stock, shares outstanding	0	0
Common stock, par value (in dollars per share)	$ 0.001	$ 0.001
Common stock, shares authorized	250,000,000	250,000,000
Common stock, shares issued	29,277,227	28,991,548
Common stock, shares outstanding	29,277,227	28,991,548

CONSOLIDATED STATEMENTS OF OPER

CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Operating Expenses:
Research and development	$ 5,430	$ 6,518
General and administrative	3,543	2,895
Total operating expenses	8,973	9,413
Loss from operations	(8,973)	(9,413)
Other income (expense):
Grant income	3,426	5,904
Other expense, net	(615)	(195)
Interest expense	(10)	(9)
Total other income, net	2,801	5,700
Loss before income tax	(6,172)	(3,713)
Income tax expense		(125)
Net Loss	(6,172)	(3,838)
Net loss attributable to common stockholders	(6,172)	(3,838)
Unrealized gain on foreign currency translation	4	1
Total comprehensive loss	$ (6,168)	$ (3,837)
Net loss per share, basic (in dollars per share)	$ (0.21)	$ (0.17)
Net loss per share, diluted (in dollars per share)	$ (0.21)	$ (0.17)
Weighted-average common shares outstanding, basic (in shares)	29,094,592	22,426,982
Weighted-average common shares outstanding, diluted (in shares)	29,094,592	22,426,982

CONSOLIDATED STATEMENTS OF STOC

CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($) $ in Thousands	At The Market Offering Common Stock	At The Market Offering Additional Paid-in Capital	At The Market Offering	Equity Line Financing Common Stock	Equity Line Financing Additional Paid-in Capital	Equity Line Financing	Common Stock	Additional Paid-in Capital	Accumulated Deficit	Accumulated Other Comprehensive Loss	Total
Beginning Balances at Dec. 31, 2021							$ 22	$ 145,453	$ (94,004)	$ (198)	$ 51,273
Beginning Balances (in shares) at Dec. 31, 2021							22,230,032
Shareholders' Equity
Exercise of common stock options								303			$ 303
Exercise of common stock options (in shares)							348,552				348,552
Equity-based compensation								1,001			$ 1,001
Other comprehensive gain										1	1
Net loss									(3,838)		(3,838)
Ending Balances at Mar. 31, 2022							$ 22	146,757	(97,842)	(197)	48,740
Ending Balances (in shares) at Mar. 31, 2022							22,578,584
Beginning Balances at Dec. 31, 2022							$ 29	155,820	(115,401)	(199)	$ 40,249
Beginning Balances (in shares) at Dec. 31, 2022							28,991,548
Shareholders' Equity
Exercise of common stock options (in shares)											0
Equity-based compensation								1,187			$ 1,187
Value of shares issued		$ 197	$ 197		$ 318	$ 318
Shares issued	95,823			189,856
Other comprehensive gain										4	4
Net loss									(6,172)		(6,172)
Ending Balances at Mar. 31, 2023							$ 29	$ 157,522	$ (121,573)	$ (195)	$ 35,783
Ending Balances (in shares) at Mar. 31, 2023							29,277,227

CONSOLIDATED STATEMENTS OF CASH

CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Cash flows from operating activities:
Net loss	$ (6,172)	$ (3,838)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	21	18
Equity-based compensation	1,187	1,001
Amortization of right-of-use assets	39	38
Issuance of common stock as commitment shares for equity line financing	318
Changes in operating assets and liabilities:
Grant receivables	2,063	(995)
Prepaid expenses and other assets	(72)	(1,082)
Accounts payable and accrued expenses	(75)	(539)
Deferred grant income and other liabilities	22	2,429
Operating lease liabilities	(36)	(20)
Net cash used in operating activities	(2,705)	(2,988)
Cash flows from investing activities:
Payments for property and equipment	(41)	(134)
Net cash used in investing activities	(41)	(134)
Cash flows from financing activities:
Proceeds from the ATM	197
Proceeds from the exercise of common stock options		303
Payments on loan payable	(207)	(394)
Net cash used in financing activities	(10)	(91)
Effect of exchange rate changes on cash and cash equivalents	4	1
Net (decrease) in cash and cash equivalents	(2,752)	(3,212)
Cash and cash equivalents
Cash and cash equivalents-beginning of period	41,562	54,721
Cash and cash equivalents-end of period	$ 38,810	$ 51,509

Description of Business and Fin

Description of Business and Financial Condition	3 Months Ended
Description of Business and Financial Condition	Mar. 31, 2023
Description of Business and Financial Condition
Description of Business and Financial Condition	1. Description of Business and Financial Condition Cognition Therapeutics, Inc. (the “Company”) was incorporated as a Delaware corporation on August 21, 2007. The Company is a biopharmaceutical company developing disease modifying therapies for central nervous system (“CNS”) disorders. The Company’s pipeline candidates were discovered using proprietary biology and chemistry platforms designed to identify novel drug targets and disease-modifying therapies that address dysregulated pathways specifically associated with neurodegenerative diseases. The Company was founded on the unique combination of biological expertise around these targets, including proprietary assays that emphasize functional responses, and proprietary medicinal chemistry intended to produce novel, high-quality small-molecule drug candidates. On July 14, 2015, the Company formed Cognition Therapeutics PTY LTD, as its wholly owned subsidiary (the “Subsidiary”), primarily for the purpose of conducting research and development efforts at facilities located in Australia. Assets and liabilities of the Subsidiary, which uses the Australian dollar as its local functional currency, are translated to United States (U.S.) dollars at year-end exchange rates. Income statement accounts are translated using the average exchange rates prevailing during the month in which income and expenses are generated. Translation adjustments are recorded to accumulated other comprehensive income (loss) (“AOCI”) within stockholders’ equity. Gains and losses from foreign currency transactions are included in net loss as a part of other income, net. On November 15, 2022, the Company closed a follow-on public offering of 5,000,000 shares of the Company’s common stock at a public offering price of $1.20 per share (“November 2022 Offering”). The gross proceeds from the November 2022 Offering were $6,000 and the net proceeds were approximately $5,184, after deducting underwriting discounts and commissions and other offering related expenses payable by the Company. Additionally, the Company granted the underwriters in the November 2022 Offering an option to purchase up to 750,000 additional shares of its common stock at the public offering price, less underwriting discounts and commissions. On December 23, 2022, the Company filed a Registration Statement on Form S-3 (File No. 333-268992) (the “Shelf”) with the Securities and Exchange Commission (“SEC”) in relation to the registration of common stock, preferred stock, debt securities, warrants, subscription rights, and/or units of any combination thereof of up to $200,000 in aggregate. The Shelf was declared effective on January 3, 2023 by the SEC. The Company also simultaneously entered into a sales agreement with Cantor Fitzgerald & Co. and B. Riley Securities, Inc., or the Sales Agents, providing for the offering, issuance and sale by the Company of up to $40,000 of its common stock from time to time in “at-the-market” offerings under the Shelf (the “ATM”). Please refer to Note 7 for further details. On March 10, 2023, the Company entered into a purchase agreement with Lincoln Park Capital Fund, LLC (“Lincoln Park”) for an equity line financing (the “Purchase Agreement”). The Purchase Agreement provides that, subject to the terms and conditions set forth therein, the Company has the right, but not the obligation, to direct Lincoln Park to purchase up to $35,000 of shares of common stock in the Company’s sole discretion, over a 36-month The Company held cash and cash equivalents of $38,810 at March 31, 2023. The Company expects that its cash and cash equivalents will enable it to fund its operating expenses and capital expenditure requirements through at least the one year period subsequent to the filing date of this Quarterly Report on Form 10-Q. However, additional funding will be necessary beyond this point to fund the Company’s future preclinical and clinical activities. The Company expects to finance its future cash needs through a combination of grant awards, equity or debt financings, collaboration agreements, strategic alliances and licensing arrangements.

Summary of Significant Accounti

Summary of Significant Accounting Policies	3 Months Ended
Summary of Significant Accounting Policies	Mar. 31, 2023
Summary of Significant Accounting Policies
Summary of Significant Accounting Policies	2. Summary of Significant Accounting Policies Basis of Presentation The accompanying consolidated financial statements as of March 31, 2023, and for the three months ended March 31, 2023 and 2022, have been prepared in accordance with the rules and regulations of the Securities and Exchange Commission (“SEC”) and generally accepted accounting principles in the United States of America (“U.S. GAAP”) for interim financial information, the instructions to Form 10-Q and Article 10 of Regulation S-X. Accordingly, they do not include all of the information and footnotes required by U.S. GAAP for complete financial statements. In the opinion of the Company’s management, the accompanying unaudited interim consolidated financial statements contain all adjustments that are necessary to present fairly the Company’s financial position as of March 31, 2023, the statements of operations and comprehensive loss and stockholders’ equity for the three months ended March 31, 2023 and 2022. Such adjustments are of a normal and recurring nature. The results for the three months ended March 31, 2023 are not necessarily indicative of the results for the year ending December 31, 2023, or for any future period. These interim financial statements should be read in conjunction with the audited financial statements as of and for the year ended December 31, 2022, and the notes thereto, which are included in the Company’s Annual Report on Form 10-K, filed with the SEC on March 23, 2023. Use of Estimates The preparation of consolidated financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and the disclosures of contingent assets and liabilities at the date of the consolidated financial statements and the reported amounts of revenues and expenses during the reporting period. Actual results could differ from those estimates. Cash and Cash Equivalents Cash and cash equivalents consist primarily of interest-bearing deposits at various financial institutions and money markets. The Company considers all highly liquid investments with an original maturity of three months or less when purchased to be cash equivalents. Receivables Grant Receivables Grant receivables relate to outstanding amounts due for reimbursable expenditures of awarded grants issued by the National Institute of Health (“NIH”) and are carried at their estimated collectible amounts. The Company expects all receivables to be collectible, and accordingly, there is no allowance for doubtful accounts required on these grant receivables. Grant income The Company generates grant income through grants from government and other (non-government) organizations. Grant income is recognized in other income (expense) in the period in which the reimbursable research and development services are incurred and the right to payment is realized. Deferred grant income represents grant proceeds received by the Company prior to the period in which the reimbursable research and development services are incurred. For the three months ended March 31, 2023 and 2022, the Company generated grant income of $3,426 and $5,904, respectively, primarily from reimbursements from the National Institute of Aging, a division of the NIH for aging research. The current and noncurrent portion of deferred grant income as of March 31, 2023 was $1,646 and $1,764, respectively, as compared to the current and noncurrent portion of deferred grant income as of December 31, 2022 of $1,702 and $1,686, respectively. The grants awarded relate to agreed-upon direct and indirect costs for specific studies or clinical trials, which may include personnel and consulting costs, costs paid to contract research organizations (“CROs”), research institutions and/or consortiums involved in the grant, as well as facilities and administrative costs. These grants are cost plus fixed fee arrangements in which the Company is reimbursed for its eligible direct and indirect costs over time, up to the maximum amount of each specific grant award. Only costs that are allowable under the grant award, certain government regulations and the NIH’s supplemental policy and procedure manual may be claimed for reimbursement, and the reimbursements are subject to routine audits from governmental agencies from time to time. While these NIH grants do not contain payback provisions, the NIH or other government agency may review the Company’s performance, cost structures and compliance with applicable laws, regulations, policies and standards and the terms and conditions of the applicable NIH grant. If any of the expenditures are found to be unallowable or allocated improperly or if the Company has otherwise violated terms of such NIH grant, the expenditures may not be reimbursed and/or the Company may be required to repay funds already disbursed. To date, the Company has not been found to have breached the terms of any NIH grant. As of March 31, 2023, the Company has been awarded grants with project periods that extend through May 31, 2026, subject to extension. Research and Development Costs The Company is involved in research and development aimed at the development of treatments for a variety of diseases related to the central nervous system, with a primary focus on Alzheimer’s disease. Research and development costs are expensed as incurred. Research and development expenses consist principally of personnel costs, including salaries, stock-based compensation, and benefits for employees, third-party license fees and other operational costs related to our research and development activities, including allocated facility-related expenses and external costs of outside vendors, and other direct and indirect costs. Non-refundable research and development costs are deferred and expensed as the related goods are delivered or services are performed. Costs for external development activities are recognized based on an evaluation of the progress to completion of specific tasks. Costs for certain research and development activities are recognized based on the pattern of performance of the individual arrangements, which may differ from the pattern of billings incurred, and are reflected in the consolidated financial statements as prepaid expenses or as accrued research and development expenses. Equity-based Compensation Following the provisions of ASC 718, Compensation — Stock Compensation Black-Scholes requires inputs based on certain subjective assumptions, including (i) the expected stock price volatility, (ii) the expected term of the award, (iii) the risk-free interest rate and (iv) expected dividends. Due to a lack of sufficient public market data for the Company’s common stock and lack of company-specific historical and implied volatility data, the Company has based its computation of expected volatility on the historical volatility of a representative group of public companies with similar characteristics to the Company, including stage of product development and life science industry focus. The historical volatility is calculated based on a period of time commensurate with expected term assumption. The Company uses the simplified method to calculate the expected term for stock options granted to employees whereby the expected term equals the arithmetic average of the vesting term and the original contractual term of the stock options due to its lack of sufficient historical data. The risk-free interest rate is based on U.S. Treasury securities with a maturity date commensurate with the expected term of the associated award. The expected dividend yield is assumed to be zero as the Company has never paid dividends and has no current plans to pay any dividends on its common stock. Prior to the IPO, due to the absence of an active market for the Company’s common stock, the Company utilized methodologies in accordance with the framework of the American Institute of Certified Public Accountants Technical Practice Aid, Valuation of Privately-Held Company Equity Securities Issued as Compensation estimated fair value of the common stock as of the measurement date. The estimated fair value of the common stock has been determined at each grant date based upon a variety of factors, including the illiquid nature of the common stock, arm’s-length sales of the Company’s capital stock (including convertible preferred stock), the effect of the rights and preferences of the preferred stockholders and the prospects of a liquidity event. Among other factors are the Company’s financial position and historical financial performance, the status of technological developments within the Company’s research, the composition and ability of the current research and management team, an evaluation or benchmark of the Company’s competition and the current business climate in the marketplace. Significant changes to the key assumptions underlying the factors used could result in different fair values of common stock at each valuation date. Subsequent to the IPO, the board of directors will determine the fair value of the shares of common stock underlying the stock-based awards based off of the closing price as reported on the Nasdaq Stock Market LLC on the grant date. Concentration of Credit Risk The Company’s financial instruments that are exposed to credit risks consist of cash and cash equivalents. The Company maintains its cash and cash equivalents in bank deposit accounts which, at times, may exceed the federally insured limit. The Company has not experienced any losses in these accounts and does not believe it is exposed to any significant credit risk related to these funds. Fair Value of Financial Instruments The Company applies ASC 820, Fair Value Measurement The carrying value of the Company’s cash and cash equivalents, grants receivable, prepaid expense, other receivables, other assets, accounts payable, accrued expenses and other liabilities approximate fair value because of the short-term maturity of these financial instruments. The valuation hierarchy is composed of three levels. The classification within the valuation hierarchy is based on the lowest level of input that is significant to the fair value measurement. The levels within the valuation hierarchy are described below: ● Level 1 — Assets and liabilities with unadjusted, quoted prices listed on active market exchanges. Inputs to the fair value measurement are observable inputs, such as quoted prices in active markets for identical assets or liabilities. ● Level 2 — Inputs to the fair value measurement are determined using prices for recently traded assets and liabilities with similar underlying terms, as well as direct or indirect observable inputs, such as interest rates and yield curves that are observable at commonly quoted intervals. ● Level 3 — Inputs to the fair value measurement are unobservable inputs, such as estimates, assumptions, and valuation techniques when little or no market data exists for the assets or liabilities. Net Loss Per Share Attributable to Common Stockholders Basic net loss attributable to common shares is computed by dividing the net loss attributable to common stockholders by the weighted-average number of shares of common stock outstanding during each period. Diluted net loss attributable to common shares includes the effect, if any, from the potential exercise or conversion of securities, such as convertible preferred stock and stock options, which would result in the issuance of incremental shares of common stock. For diluted net loss per share, the weighted-average number of shares of common stock is the same for basic net loss per share due to the fact that when a net loss exists, dilutive securities are not included in the calculation as the impact is anti-dilutive. Segments The Company has determined that it operates and manages one operating segment, which is the business of developing and commercializing therapeutics. The Company’s chief operating decision maker, its chief executive officer, reviews financial information on an aggregate basis for the purpose of allocating resources. Emerging Growth Company Status The Company is an emerging growth company, as defined in the Jumpstart Our Business Startups Act of 2012 (the “JOBS Act”). Under the JOBS Act, emerging growth companies can delay adopting new or revised accounting standards issued subsequent to the enactment of the JOBS Act until such time as those standards apply to private companies. The Company has elected to use this extended transition period for complying with new or revised accounting standards that have different effective dates for public and private companies until the earlier of the date that it is (a) no longer an emerging growth company or (b) affirmatively and irrevocably opt out of the extended transition period provided in the JOBS Act. As a result, these financial statements may not be comparable to companies that comply with the new or revised accounting pronouncements as of public company effective dates. Recent Accounting Pronouncements There have been no new pronouncements issued during the three months ended March 31, 2023, which could be expected to materially impact the Company’s consolidated financial statements. Income taxes In accordance with ASC 270, Interim Reporting Income Taxes

Financial Instruments and Fair

Financial Instruments and Fair Value Measurements	3 Months Ended
Financial Instruments and Fair Value Measurements	Mar. 31, 2023
Financial Instruments and Fair Value Measurements
Financial Instruments and Fair Value Measurements	3. Financial Instruments and Fair Value Measurements Financial assets and liabilities measured at fair value are summarized below: As of March 31, 2023 Significant Quoted Priced in Significant Other Unobservable Active Markets Observable Inputs Inputs (Level 1) (Level 2) (Level 3) Total Assets: Money market funds $ 37,752 $ — $ — $ 37,752 Total assets $ 37,752 $ — $ — $ 37,752 As of December 31, 2022 Significant Quoted Priced in Significant Other Unobservable Active Markets Observable Inputs Inputs (Level 1) (Level 2) (Level 3) Total Assets: Money market funds $ 37,479 $ — $ — $ 37,479 Total assets $ 37,479 $ — $ — $ 37,479

Accrued Expenses

Accrued Expenses	3 Months Ended
Accrued Expenses	Mar. 31, 2023
Accrued Expenses
Accrued Expenses	4. Accrued Expenses Accrued expense consists of the following as of: As of March 31, 2023 December 31, 2022 Employee compensation, benefits, and related accruals $ 480 $ 870 Research and development costs 1,401 900 Professional fees and other accruals 234 324 Total $ 2,115 $ 2,094

Other Current Liabilities

Other Current Liabilities	3 Months Ended
Other Current Liabilities	Mar. 31, 2023
Other Current Liabilities.
Other Current Liabilities	5. Other Current Liabilities In October 2022, the Company entered into an insurance premium financing agreement with a lender. Under the agreement, the Company financed $838 of certain premiums at a 6.85% annual interest rate. Payments of approximately $72 are due monthly from November 2022 through October 2023. As of March 31, 2023 and December 31, 2022, the outstanding principal of the loan was $427 and $634, respectively, and is included in other current liabilities on the consolidated balance sheet.

Commitments and Contingencies

Commitments and Contingencies	3 Months Ended
Commitments and Contingencies	Mar. 31, 2023
Commitments and Contingencies.
Commitments and Contingencies	6. Commitments and Contingencies Operating Leases Amounts reported in the consolidated balance sheets for leases where the Company is the lessee as of March 31, 2023 were as follows, in thousands: As of March 31, 2023 Assets Operating lease assets $ 774 Total operating lease assets $ 774 Liabilities Current Operating lease liabilities $ 157 Noncurrent Operating lease liabilities, net of current 651 Total operating lease liabilities $ 808 Operating lease costs for the three months ended March 31, 2023 and 2022 was $54 and $50, respectively. The maturities of the operating lease liabilities and minimum lease payments as of March 31, 2023 were as follows: For the Years Ended December 31, Operating Leases 2023 (remaining) $ 159 2024 221 2025 222 2026 154 2027 87 Thereafter 126 Total undiscounted lease payments $ 969 Less: Imputed interest (161) Present value of operating lease liabilities $ 808 The following table summarizes the lease term and discount rate as of March 31, 2023: As of March 31, 2023 Weighted-average remaining lease term (years) Operating leases 4.8 Weighted-average discount rate Operating leases 8.2% The following table summarizes the supplemental cash flow information related to the Company’s operating leases: Three Months Ended March 31, (In Thousands) 2023 2022 Operating cash flows used for operating leases $ 50 $ 32 Litigation and Contingencies From time to time, the Company may be involved in disputes or regulatory inquiries that arise in the ordinary course of business. When the Company determines that a loss is both probable and reasonably estimable, a liability is recorded and disclosed if the amount is material to the financial statements taken as a whole. When a material loss contingency is only reasonably possible, the Company does not record a liability but instead discloses the nature and the amount of the claim and an estimate of the loss or range of loss, if such an estimate can reasonably be made. As of March 31, 2023 and December 31, 2022, there was no litigation or contingency with at least a reasonable possibility of a material loss.

Stockholders' Equity

Stockholders' Equity	3 Months Ended
Stockholders' Equity	Mar. 31, 2023
Stockholders' Equity.
Stockholders' Equity	7. Stockholders’ Equity Common and Preferred Stock The Company is authorized to issue up to 250,000,000 shares of common stock with a par value of $0.001 per share, and 10,000,000 shares of preferred stock with a par value of $0.001 per share. Common stockholders are entitled to dividends if and when declared by the Company’s board of directors subject to the rights of the preferred stockholders. As of March 31, 2023, no dividends on common stock had been declared by the Company. ATM On December 23, 2022, the Company filed a shelf registration statement on Form S-3 with the SEC in relation to the registration of common stock, preferred stock, debt securities, warrants, subscription rights, and/or units of any combination thereof of up to $200,000 in aggregate (the “Shelf”). The Shelf was declared effective on January 3, 2023 by the SEC. The Company also simultaneously entered into a sales agreement with Cantor Fitzgerald & Co. and B. Riley Securities, Inc., or the Sales Agents, providing for the offering, issuance and sale by the Company of up to $40,000 of its common stock from time to time in ATM offerings under the Shelf. The Company sold Lincoln Park Purchase Agreement On March 10, 2023, the Company entered into a purchase agreement with Lincoln Park for an equity line financing. The Purchase Agreement provides that, subject to the terms and conditions set forth therein, the Company has the right, but not the obligation, to direct Lincoln Park to purchase up to $35,000 of shares of common stock in the Company’s sole discretion, over a 36-month

Equity-based Compensation

Equity-based Compensation	3 Months Ended
Equity-based Compensation	Mar. 31, 2023
Equity-based Compensation
Equity-based Compensation	8. Equity-based Compensation 2021 Equity Incentive Plan On October 7, 2021, the date upon which the Company’s Registration Statement on Form S-1 in connection with the IPO was declared effective, the Company’s 2021 Equity Incentive Plan (the “2021 Plan”) became effective. On the same date, the Company ceased granting awards under its 2017 Equity Incentive Plan (the “2017 Plan”). The 2021 Plan authorizes the award of both equity-based and cash-based incentive awards, including: (i) stock options (both incentive stock options and nonqualified stock options), (ii) stock appreciation rights, (iii) restricted stock awards, (iv) restricted stock units, or RSUs, and (v) cash or other stock-based awards. Incentive stock options may be granted only to employees. All other types of awards may be issued to employees, directors, consultants, and other service providers. As of March 31, 2023, the aggregate number of shares of common stock of the Company that may be issued under the Plan is 3,224,254. The number of shares reserved for issuance under the 2021 Plan increased automatically on January 1, 2023 pursuant to an evergreen provision therein by 1,449,577 shares, representing 5.0% of total common shares outstanding at December 31, 2022. The aggregate number of shares will increase each anniversary of such date prior to the termination of the 2021 Plan, equal to the lesser of (i) 5% of the Company’s shares of common stock issued and outstanding on the last day of the immediately preceding fiscal year and (ii) such smaller number of shares as determined by the Company’s Board of Directors or the compensation committee. No more than 7,543,185 shares of common stock may be issued under the 2021 Plan through incentive stock options. Shares subject to the 2017 Plan or the 2007 Equity Incentive Plan (the “2007 Plan” and collectively with the 2017 Plan, the “Prior Plans”) that expire, terminate or are cancelled or forfeited for any reason after the effectiveness of the 2021 Plan will be added (or added back) to the shares available for issuance under the 2021 Plan. The total number of shares underlying the Prior Plan awards that may be recycled into the 2021 Plan will not exceed 4,334,131 shares. 2017 Equity Incentive Plan On September 15, 2017, the Company’s board of directors approved the 2017 Plan, which provides for the granting of incentive stock options, non-qualified stock options and stock awards to employees, certain consultants and directors. The board of directors, or its designated committee, has the sole authority to select the individuals to whom awards are granted and determine the terms of each award, including the number of shares and the schedule upon which the award becomes exercisable. Upon the effectiveness of the 2021 Plan, no further awards will be granted under the 2017 Plan. The aggregate number of shares of common stock of the Company that may be issued under the 2017 Plan is 4,334,131 (taking into account shares of common stock that may become issuable pursuant to Section 3(b) of the 2017 Plan in respect of shares of common stock reserved under the Company’s Amended and Restated 2007 Equity Incentive Plan). The 2021 Plan allows for a provision for shares granted under the Prior Plans which are cancelled, forfeited, exchanged or surrendered without having been exercised to subsequently be available for reissuance under the 2021 Plan. Employee Stock Purchase Plan The Company’s board of directors approved the Employee Stock Purchase Plan (the “ESPP”) prior to the closing of the IPO. Under the ESPP, the Company may provide employees and employees of the Subsidiary with an opportunity to purchase shares of the Company’s common stock at a discounted purchase price. As of March 31, 2023, subject to adjustment as provided in the ESPP, a total of 209,532 shares of common stock are authorized and reserved for issuance under the ESPP. Subject to prior approval by the board of directors in each instance, on or about January 1, 2022 and each anniversary of such date thereafter prior to the termination of the ESPP, the number of shares of common stock authorized and reserved for issuance under the ESPP will be increased by a number of shares of common stock equal to the least of (i) 1,000,000 shares of common stock, (ii) 1% of the shares of common stock outstanding on the final day of the immediately preceding calendar year, and (iii) such smaller number of shares of common stock as determined by the board of directors. Such shares of common stock may be newly issued shares, treasury shares or shares acquired on the open market. In the event that any dividend or other distribution (whether in the form of cash, our common stock, or other property), recapitalization, stock split, reverse stock split, reorganization, merger, consolidation, split-up, spin-off, or exchange of common stock or other securities, or other change in the structure affecting common stock occurs, then in order to prevent dilution or enlargement of the benefits or potential benefits intended to be made available under the ESPP, the compensation committee will, in such manner as it deems equitable, adjust the number of shares and class of common stock that may be delivered under the ESPP, the purchase price per share and the number of shares covered by each outstanding option under the ESPP, and the numerical limits described above. Stock Options The fair value of options granted was estimated on the date of grant using the Black-Scholes option pricing model with the following assumptions: Three Months Ended March 31, 2023 2022 Fair value of common stock $1.65 – $2.12 $3.05 Expected volatility 92.29% – 92.68% 91.29% Risk-free interest rate 3.46% – 4.21% 2.36% Dividend yield 0.00% 0.00% Expected term (years) 6.18 – 6.21 6.08 Expected Term Risk-Free Interest Rate Expected Volatility Dividend Yield Fair Value of Common Stock Activity for options was as follows: Options Outstanding Weighted Weighted- Aggregate Average Average Intrinsic Remaining Number of Exercise Value Contractual Life Options Price (in 000’s) (In Years) Balance, December 31, 2022 3,679,468 $ 5.13 $ 2,085 6.7 Options granted 412,720 $ 2.08 Options exercised — $ — Options forfeited — $ — Options expired (2,182) $ 3.01 Balance, March 31, 2023 4,090,006 $ 5.13 $ 2,085 6.7 Exercisable as of March 31, 2023 2,430,915 $ 4.75 $ 1,506 6.0 The weighted-average grant date fair value of stock options granted was $1.62 and $2.31 during the three months ended March 31, 2023 and 2022, respectively. There were 412,720 stock options granted at an aggregate fair value of $668 for the three months ended March 31, 2023 and 212,450 stock options granted at an aggregate fair value of $491 for the three months ended March 31, 2022. During the three months ended March 31, 2023 and 2022, there were 0 and 348,552 stock options exercised, respectively, with an aggregate grant date fair value of $0 and $209, respectively. The intrinsic value of stock options exercised during the three months ended March 31, 2023 was $0, and was $1,084 for the three months ended March 31, 2022. Restricted Stock Units The fair values of restricted stock units (“RSUs”) are based on the fair market value of the Company’s common stock on the date of grant. Each RSU represents a contingent right to receive one share of the Company’s common stock upon vesting. The RSUs will vest annually over three years on each anniversary of the Grant Date. The following table summarizes the Company’s RSU activity for the three months ended March 31, 2023: Number of Weighted-Average Restricted Grant Date Stock Units Fair Value Outstanding at December 31, 2022 — $ — Granted 375,870 $ 2.09 Vested — $ — Forfeited — $ — Outstanding at March 31, 2023 375,870 $ 2.09 Equity-based Compensation Expense The Company recorded total equity-based compensation expense in the statement of operations and comprehensive loss related to stock options and restricted stock units as follows: Three Months Ended March 31, 2023 2022 Research and development $ 157 $ 234 General and administrative 1,030 767 Total equity-based compensation $ 1,187 $ 1,001 As of March 31, 2023, total future compensation expense related to unvested awards yet to be recognized by the Company was $6,944, which is expected to be recognized over a weighted-average remaining vesting period of approximately 2.0 years.

Net Loss per Share

Net Loss per Share	3 Months Ended
Net Loss per Share	Mar. 31, 2023
Net Loss per Share
Net Loss per Share	9. Net Loss per Share The following outstanding potentially dilutive common stock equivalents have been excluded from the calculation of diluted net loss per share attributable to common stockholders for the periods presented due to their antidilutive effect: March 31, 2023 2022 Options issued and outstanding 4,090,006 5,107,974 Restricted stock units issued and oustanding 375,870 — Total 4,465,876 5,107,974

Summary of Significant Accoun_2

Summary of Significant Accounting Policies (Policies)	3 Months Ended
Summary of Significant Accounting Policies (Policies)	Mar. 31, 2023
Summary of Significant Accounting Policies
Basis of Presentation	Basis of Presentation The accompanying consolidated financial statements as of March 31, 2023, and for the three months ended March 31, 2023 and 2022, have been prepared in accordance with the rules and regulations of the Securities and Exchange Commission (“SEC”) and generally accepted accounting principles in the United States of America (“U.S. GAAP”) for interim financial information, the instructions to Form 10-Q and Article 10 of Regulation S-X. Accordingly, they do not include all of the information and footnotes required by U.S. GAAP for complete financial statements. In the opinion of the Company’s management, the accompanying unaudited interim consolidated financial statements contain all adjustments that are necessary to present fairly the Company’s financial position as of March 31, 2023, the statements of operations and comprehensive loss and stockholders’ equity for the three months ended March 31, 2023 and 2022. Such adjustments are of a normal and recurring nature. The results for the three months ended March 31, 2023 are not necessarily indicative of the results for the year ending December 31, 2023, or for any future period. These interim financial statements should be read in conjunction with the audited financial statements as of and for the year ended December 31, 2022, and the notes thereto, which are included in the Company’s Annual Report on Form 10-K, filed with the SEC on March 23, 2023.
Use of Estimates	Use of Estimates The preparation of consolidated financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and the disclosures of contingent assets and liabilities at the date of the consolidated financial statements and the reported amounts of revenues and expenses during the reporting period. Actual results could differ from those estimates.
Cash and Cash Equivalents	Cash and Cash Equivalents Cash and cash equivalents consist primarily of interest-bearing deposits at various financial institutions and money markets. The Company considers all highly liquid investments with an original maturity of three months or less when purchased to be cash equivalents.
Receivables	Receivables Grant Receivables Grant receivables relate to outstanding amounts due for reimbursable expenditures of awarded grants issued by the National Institute of Health (“NIH”) and are carried at their estimated collectible amounts. The Company expects all receivables to be collectible, and accordingly, there is no allowance for doubtful accounts required on these grant receivables.
Grant income	Grant income The Company generates grant income through grants from government and other (non-government) organizations. Grant income is recognized in other income (expense) in the period in which the reimbursable research and development services are incurred and the right to payment is realized. Deferred grant income represents grant proceeds received by the Company prior to the period in which the reimbursable research and development services are incurred. For the three months ended March 31, 2023 and 2022, the Company generated grant income of $3,426 and $5,904, respectively, primarily from reimbursements from the National Institute of Aging, a division of the NIH for aging research. The current and noncurrent portion of deferred grant income as of March 31, 2023 was $1,646 and $1,764, respectively, as compared to the current and noncurrent portion of deferred grant income as of December 31, 2022 of $1,702 and $1,686, respectively. The grants awarded relate to agreed-upon direct and indirect costs for specific studies or clinical trials, which may include personnel and consulting costs, costs paid to contract research organizations (“CROs”), research institutions and/or consortiums involved in the grant, as well as facilities and administrative costs. These grants are cost plus fixed fee arrangements in which the Company is reimbursed for its eligible direct and indirect costs over time, up to the maximum amount of each specific grant award. Only costs that are allowable under the grant award, certain government regulations and the NIH’s supplemental policy and procedure manual may be claimed for reimbursement, and the reimbursements are subject to routine audits from governmental agencies from time to time. While these NIH grants do not contain payback provisions, the NIH or other government agency may review the Company’s performance, cost structures and compliance with applicable laws, regulations, policies and standards and the terms and conditions of the applicable NIH grant. If any of the expenditures are found to be unallowable or allocated improperly or if the Company has otherwise violated terms of such NIH grant, the expenditures may not be reimbursed and/or the Company may be required to repay funds already disbursed. To date, the Company has not been found to have breached the terms of any NIH grant. As of March 31, 2023, the Company has been awarded grants with project periods that extend through May 31, 2026, subject to extension.
Research and Development Costs	Research and Development Costs The Company is involved in research and development aimed at the development of treatments for a variety of diseases related to the central nervous system, with a primary focus on Alzheimer’s disease. Research and development costs are expensed as incurred. Research and development expenses consist principally of personnel costs, including salaries, stock-based compensation, and benefits for employees, third-party license fees and other operational costs related to our research and development activities, including allocated facility-related expenses and external costs of outside vendors, and other direct and indirect costs. Non-refundable research and development costs are deferred and expensed as the related goods are delivered or services are performed. Costs for external development activities are recognized based on an evaluation of the progress to completion of specific tasks. Costs for certain research and development activities are recognized based on the pattern of performance of the individual arrangements, which may differ from the pattern of billings incurred, and are reflected in the consolidated financial statements as prepaid expenses or as accrued research and development expenses.
Equity-based Compensation	Equity-based Compensation Following the provisions of ASC 718, Compensation — Stock Compensation Black-Scholes requires inputs based on certain subjective assumptions, including (i) the expected stock price volatility, (ii) the expected term of the award, (iii) the risk-free interest rate and (iv) expected dividends. Due to a lack of sufficient public market data for the Company’s common stock and lack of company-specific historical and implied volatility data, the Company has based its computation of expected volatility on the historical volatility of a representative group of public companies with similar characteristics to the Company, including stage of product development and life science industry focus. The historical volatility is calculated based on a period of time commensurate with expected term assumption. The Company uses the simplified method to calculate the expected term for stock options granted to employees whereby the expected term equals the arithmetic average of the vesting term and the original contractual term of the stock options due to its lack of sufficient historical data. The risk-free interest rate is based on U.S. Treasury securities with a maturity date commensurate with the expected term of the associated award. The expected dividend yield is assumed to be zero as the Company has never paid dividends and has no current plans to pay any dividends on its common stock. Prior to the IPO, due to the absence of an active market for the Company’s common stock, the Company utilized methodologies in accordance with the framework of the American Institute of Certified Public Accountants Technical Practice Aid, Valuation of Privately-Held Company Equity Securities Issued as Compensation estimated fair value of the common stock as of the measurement date. The estimated fair value of the common stock has been determined at each grant date based upon a variety of factors, including the illiquid nature of the common stock, arm’s-length sales of the Company’s capital stock (including convertible preferred stock), the effect of the rights and preferences of the preferred stockholders and the prospects of a liquidity event. Among other factors are the Company’s financial position and historical financial performance, the status of technological developments within the Company’s research, the composition and ability of the current research and management team, an evaluation or benchmark of the Company’s competition and the current business climate in the marketplace. Significant changes to the key assumptions underlying the factors used could result in different fair values of common stock at each valuation date. Subsequent to the IPO, the board of directors will determine the fair value of the shares of common stock underlying the stock-based awards based off of the closing price as reported on the Nasdaq Stock Market LLC on the grant date.
Concentration of Credit Risk	Concentration of Credit Risk The Company’s financial instruments that are exposed to credit risks consist of cash and cash equivalents. The Company maintains its cash and cash equivalents in bank deposit accounts which, at times, may exceed the federally insured limit. The Company has not experienced any losses in these accounts and does not believe it is exposed to any significant credit risk related to these funds.
Fair Value of Financial Instruments	Fair Value of Financial Instruments The Company applies ASC 820, Fair Value Measurement The carrying value of the Company’s cash and cash equivalents, grants receivable, prepaid expense, other receivables, other assets, accounts payable, accrued expenses and other liabilities approximate fair value because of the short-term maturity of these financial instruments. The valuation hierarchy is composed of three levels. The classification within the valuation hierarchy is based on the lowest level of input that is significant to the fair value measurement. The levels within the valuation hierarchy are described below: ● Level 1 — Assets and liabilities with unadjusted, quoted prices listed on active market exchanges. Inputs to the fair value measurement are observable inputs, such as quoted prices in active markets for identical assets or liabilities. ● Level 2 — Inputs to the fair value measurement are determined using prices for recently traded assets and liabilities with similar underlying terms, as well as direct or indirect observable inputs, such as interest rates and yield curves that are observable at commonly quoted intervals. ● Level 3 — Inputs to the fair value measurement are unobservable inputs, such as estimates, assumptions, and valuation techniques when little or no market data exists for the assets or liabilities.
Net Loss Per Share Attributable to Common Stockholders	Net Loss Per Share Attributable to Common Stockholders Basic net loss attributable to common shares is computed by dividing the net loss attributable to common stockholders by the weighted-average number of shares of common stock outstanding during each period. Diluted net loss attributable to common shares includes the effect, if any, from the potential exercise or conversion of securities, such as convertible preferred stock and stock options, which would result in the issuance of incremental shares of common stock. For diluted net loss per share, the weighted-average number of shares of common stock is the same for basic net loss per share due to the fact that when a net loss exists, dilutive securities are not included in the calculation as the impact is anti-dilutive.
Segments	Segments The Company has determined that it operates and manages one operating segment, which is the business of developing and commercializing therapeutics. The Company’s chief operating decision maker, its chief executive officer, reviews financial information on an aggregate basis for the purpose of allocating resources.
Emerging Growth Company Status	Emerging Growth Company Status The Company is an emerging growth company, as defined in the Jumpstart Our Business Startups Act of 2012 (the “JOBS Act”). Under the JOBS Act, emerging growth companies can delay adopting new or revised accounting standards issued subsequent to the enactment of the JOBS Act until such time as those standards apply to private companies. The Company has elected to use this extended transition period for complying with new or revised accounting standards that have different effective dates for public and private companies until the earlier of the date that it is (a) no longer an emerging growth company or (b) affirmatively and irrevocably opt out of the extended transition period provided in the JOBS Act. As a result, these financial statements may not be comparable to companies that comply with the new or revised accounting pronouncements as of public company effective dates.
Recent Accounting Pronouncements	Recent Accounting Pronouncements There have been no new pronouncements issued during the three months ended March 31, 2023, which could be expected to materially impact the Company’s consolidated financial statements.
Income Taxes	Income taxes In accordance with ASC 270, Interim Reporting Income Taxes

Financial Instruments and Fai_2

Financial Instruments and Fair Value Measurements (Tables)	3 Months Ended
Financial Instruments and Fair Value Measurements (Tables)	Mar. 31, 2023
Financial Instruments and Fair Value Measurements
Summary of financial assets and liabilities measured at fair value	As of March 31, 2023 Significant Quoted Priced in Significant Other Unobservable Active Markets Observable Inputs Inputs (Level 1) (Level 2) (Level 3) Total Assets: Money market funds $ 37,752 $ — $ — $ 37,752 Total assets $ 37,752 $ — $ — $ 37,752 As of December 31, 2022 Significant Quoted Priced in Significant Other Unobservable Active Markets Observable Inputs Inputs (Level 1) (Level 2) (Level 3) Total Assets: Money market funds $ 37,479 $ — $ — $ 37,479 Total assets $ 37,479 $ — $ — $ 37,479

Accrued Expenses (Tables)

Accrued Expenses (Tables)	3 Months Ended
Accrued Expenses (Tables)	Mar. 31, 2023
Accrued Expenses
Schedule of accrued expenses	As of March 31, 2023 December 31, 2022 Employee compensation, benefits, and related accruals $ 480 $ 870 Research and development costs 1,401 900 Professional fees and other accruals 234 324 Total $ 2,115 $ 2,094

Commitments and Contingencies (

Commitments and Contingencies (Tables)	3 Months Ended
Commitments and Contingencies (Tables)	Mar. 31, 2023
Commitments and Contingencies.
Schedule of lease cost	Amounts reported in the consolidated balance sheets for leases where the Company is the lessee as of March 31, 2023 were as follows, in thousands: As of March 31, 2023 Assets Operating lease assets $ 774 Total operating lease assets $ 774 Liabilities Current Operating lease liabilities $ 157 Noncurrent Operating lease liabilities, net of current 651 Total operating lease liabilities $ 808 The following table summarizes the lease term and discount rate as of March 31, 2023: As of March 31, 2023 Weighted-average remaining lease term (years) Operating leases 4.8 Weighted-average discount rate Operating leases 8.2% The following table summarizes the supplemental cash flow information related to the Company’s operating leases: Three Months Ended March 31, (In Thousands) 2023 2022 Operating cash flows used for operating leases $ 50 $ 32
Schedule of minimum lease commitments	For the Years Ended December 31, Operating Leases 2023 (remaining) $ 159 2024 221 2025 222 2026 154 2027 87 Thereafter 126 Total undiscounted lease payments $ 969 Less: Imputed interest (161) Present value of operating lease liabilities $ 808

Equity-based Compensation (Tabl

Equity-based Compensation (Tables)	3 Months Ended
Equity-based Compensation (Tables)	Mar. 31, 2023
Equity-based Compensation
Schedule of fair value of options granted using the Black-Scholes option pricing model	Three Months Ended March 31, 2023 2022 Fair value of common stock $1.65 – $2.12 $3.05 Expected volatility 92.29% – 92.68% 91.29% Risk-free interest rate 3.46% – 4.21% 2.36% Dividend yield 0.00% 0.00% Expected term (years) 6.18 – 6.21 6.08
Summary of activity for options	Options Outstanding Weighted Weighted- Aggregate Average Average Intrinsic Remaining Number of Exercise Value Contractual Life Options Price (in 000’s) (In Years) Balance, December 31, 2022 3,679,468 $ 5.13 $ 2,085 6.7 Options granted 412,720 $ 2.08 Options exercised — $ — Options forfeited — $ — Options expired (2,182) $ 3.01 Balance, March 31, 2023 4,090,006 $ 5.13 $ 2,085 6.7 Exercisable as of March 31, 2023 2,430,915 $ 4.75 $ 1,506 6.0
Schedule of restricted stock units award activity	Number of Weighted-Average Restricted Grant Date Stock Units Fair Value Outstanding at December 31, 2022 — $ — Granted 375,870 $ 2.09 Vested — $ — Forfeited — $ — Outstanding at March 31, 2023 375,870 $ 2.09
Schedule of total equity-based compensation expense	Three Months Ended March 31, 2023 2022 Research and development $ 157 $ 234 General and administrative 1,030 767 Total equity-based compensation $ 1,187 $ 1,001

Net Loss per Share (Tables)

Net Loss per Share (Tables)	3 Months Ended
Net Loss per Share (Tables)	Mar. 31, 2023
Net Loss per Share
Schedule of outstanding potentially dilutive common stock	March 31, 2023 2022 Options issued and outstanding 4,090,006 5,107,974 Restricted stock units issued and oustanding 375,870 — Total 4,465,876 5,107,974

Description of Business and F_2

Description of Business and Financial Condition (Details) - USD ($) $ / shares in Units, $ in Thousands				3 Months Ended
	Mar. 10, 2023	Dec. 23, 2022	Nov. 15, 2022	Mar. 31, 2023	Dec. 31, 2022
Description of Business and Financial Condition
Aggregate offering price		$ 200,000
Cash and cash equivalents				$ 38,810	$ 41,562
Follow-on Public Offering
Description of Business and Financial Condition
Shares issued			5,000,000
Offering price per share			$ 1.20
Gross proceeds			$ 6,000
Net proceeds			$ 5,184
Over-Allotment Option
Description of Business and Financial Condition
Shares issued			750,000
At The Market Offering
Description of Business and Financial Condition
Aggregate offering price		200,000
At The Market Offering \| Cantor Fitzgerald & Co. and B. Riley Securities, Inc.
Description of Business and Financial Condition
Shares issued				95,823
Maximum value of stock to be issued under agreement		$ 40,000
Equity Line Financing \| Lincoln Park Capital Fund LLC
Description of Business and Financial Condition
Shares issued	189,856
Maximum value of stock to be issued under agreement	$ 35,000
Term of agreement	36 months

Summary of Significant Accoun_3

Summary of Significant Accounting Policies (Details) $ in Thousands	3 Months Ended
	Mar. 31, 2023 USD ($) segment	Mar. 31, 2022 USD ($)	Dec. 31, 2022 USD ($)
Summary of Significant Accounting Policies
Allowance for doubtful accounts on grants receivable	$ 0
Grant income	3,426	$ 5,904
Deferred grant income, current	1,646		$ 1,702
Deferred grant income, noncurrent	1,764		1,686
Unrecognized income tax	$ 0		$ 0
Expected dividend yield	0%	0%
Number of operating segments \| segment	1

Financial Instruments and Fai_3

Financial Instruments and Fair Value Measurements (Details) - USD ($) $ in Thousands	Mar. 31, 2023	Dec. 31, 2022
Assets:
Total assets	$ 37,752	$ 37,479
Quoted Priced in Active Markets (Level 1)
Assets:
Total assets	37,752	37,479
Money market funds
Assets:
Money market funds	37,752	37,479
Money market funds \| Quoted Priced in Active Markets (Level 1)
Assets:
Money market funds	$ 37,752	$ 37,479

Accrued Expenses (Details)

Accrued Expenses (Details) - USD ($) $ in Thousands	Mar. 31, 2023	Dec. 31, 2022
Accrued Expenses
Employee compensation, benefits, and related accruals	$ 480	$ 870
Research and development costs	1,401	900
Legal reserves, professional fees, and other accruals	234	324
Total	$ 2,115	$ 2,094

Other Current Liabilities (Deta

Other Current Liabilities (Details) - USD ($) $ in Thousands	12 Months Ended
	Oct. 31, 2023	Mar. 31, 2023	Dec. 31, 2022	Oct. 31, 2022
Other Current Liabilities
Other Current Liabilities
Short-term debt		$ 427	$ 634
Insurance Premium Financing Agreement
Other Current Liabilities
Face amount				$ 838
Interest rate (as a percent)				6.85%
Periodic payment	$ 72

Commitments and Contingencies -

Commitments and Contingencies - Leases (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022	Dec. 31, 2022
Assets
Operating lease assets	$ 774
Total operating lease assets	774		$ 813
Current liabilities:
Operating lease liabilities, current	157		149
Noncurrent
Operating lease liabilities, net of current portion	651		$ 695
Total operating lease liabilities	808
Operating lease costs	$ 54	$ 50

Commitments and Contingencies_2

Commitments and Contingencies (Details) $ in Thousands	Mar. 31, 2023 USD ($)
Minimum lease commitments
2023 (remaining)	$ 159
2024	221
2025	222
2026	154
2027	87
Thereafter	126
Total undiscounted lease payments	969
Less: Imputed interest	(161)
Total operating lease liabilities	$ 808

Commitments and Contingencies_3

Commitments and Contingencies - Lease Term And Discount (Details)	Mar. 31, 2023
Commitments and Contingencies.
Weighted-average remaining lease term (years)	4 years 9 months 18 days
Weighted-average discount rate	8.20%

Commitments and Contingencies_4

Commitments and Contingencies - Operating Lease Liabilities (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Commitments and Contingencies.
Operating cash flows used for operating leases	$ 50	$ 32

Stockholders' Equity - (Details

Stockholders' Equity - (Details) - USD ($) $ / shares in Units, $ in Thousands			3 Months Ended
	Mar. 10, 2023	Dec. 23, 2022	Mar. 31, 2023	Mar. 31, 2022	Dec. 31, 2022
Common Stock
Common stock, shares authorized			250,000,000		250,000,000
Common stock, par value (in dollars per share)			$ 0.001		$ 0.001
Preferred stock shares authorized			10,000,000		10,000,000
Preferred stock, par value (in dollars per share)			$ 0.001		$ 0.001
Dividend declared			$ 0
Aggregate offering price		$ 200,000
Gross proceeds from simple agreements for future equity			197
Other expense, net			$ (615)	$ (195)
At The Market Offering
Common Stock
Aggregate offering price		200,000
Cantor Fitzgerald And Co and B Riley Securities Inc \| At The Market Offering
Common Stock
Maximum value of stock to be issued under agreement		$ 40,000
Shares issued			95,823
Gross proceeds from simple agreements for future equity			$ 197
Remaining of common stock available for sale			$ 39,803
Lincoln Park Capital Fund LLC \| Equity Line Financing
Common Stock
Maximum value of stock to be issued under agreement	$ 35,000
Term of agreement	36 months
Shares issued	189,856
Other expense, net	$ 318

Equity-based Compensation (Deta

Equity-based Compensation (Details) - shares	1 Months Ended	3 Months Ended
Equity-based Compensation (Details) - shares	Jan. 31, 2023	Mar. 31, 2023	Jan. 01, 2023	Sep. 15, 2017
Amended and Restated 2017 Equity Incentive Plan
Equity-based Compensation
Number of shares authorized				4,334,131
2021 Equity Incentive Plan
Equity-based Compensation
Number of shares authorized		3,224,254
Common stock shares reserved for issuance		7,543,185	1,449,577
Maximum percentage of common shares issued and outstanding	5%	5%
Number of shares that may be recycled		4,334,131
ESPP
Equity-based Compensation
Number of shares authorized		209,532
Maximum percentage of common shares issued and outstanding		1%
Number of additional shares authorized		1,000,000

Equity-based Compensation - Fai

Equity-based Compensation - Fair value of options (Details) - $ / shares	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Fair value of common stock (in dollars per share)		$ 3.05
Expected volatility		91.29%
Expected volatility, minimum	92.29%
Expected volatility, maximum	92.68%
Risk-free interest rate		2.36%
Risk-free interest rate, minimum	3.46%
Risk-free interest rate, maximum	4.21%
Dividend yield	0%	0%
Expected term (years)		6 years 29 days
Minimum
Fair value of common stock (in dollars per share)	$ 1.65
Expected term (years)	6 years 2 months 4 days
Maximum
Fair value of common stock (in dollars per share)	$ 2.12
Expected term (years)	6 years 2 months 15 days

Equity-based Compensation - Act

Equity-based Compensation - Activity for options (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended		12 Months Ended
	Mar. 31, 2023	Mar. 31, 2022	Dec. 31, 2022
Number of Options
Beginning Balance (in shares)	3,679,468
Options granted (in shares)	412,720	212,450
Options exercised (in shares)	0	(348,552)
Options expired (in shares)	(2,182)
Ending Balance (in shares)	4,090,006		3,679,468
Exercisable (in shares)	2,430,915
Weighted Average Exercise Price
Beginning Balance (in dollars per share)	$ 5.13
Options granted (in dollars per share)	2.08
Options expired (in dollars per share)	3.01
Ending Balance (in dollars per share)	5.13		$ 5.13
Exercisable (in dollars per share)	$ 4.75
Aggregate Intrinsic Value
Aggregate Intrinsic Value	$ 2,085		$ 2,085
Aggregate Intrinsic Value - Exercisable	$ 1,506
Weighted Average Remaining Contractual Life	6 years 8 months 12 days		6 years 8 months 12 days
Weighted Average Remaining Contractual Life -Exercisable	6 years

Equity-based Compensation - Add

Equity-based Compensation - Additional Information (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Equity-based Compensation
Weighted-average grant date fair value (in dollars per share)	$ 1.62	$ 2.31
Options granted (in shares)	412,720	212,450
Fair value of options granted	$ 668	$ 491
Options exercised (in shares)	0	348,552
Fair value of options exercised	$ 0	$ 209
Intrinsic value of stock options exercised	$ 0	$ 1,084
Restricted Stock Units
Equity-based Compensation
Number of shares issuable for each award	1
Vesting period	3 years

Equity-based Compensation - Res

Equity-based Compensation - Restricted Stock Units (Details) - Restricted Stock Units	3 Months Ended
	Mar. 31, 2023 $ / shares shares
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Granted \| shares	375,870
Ending balance \| shares	375,870
Equity based compensation
Granted \| $ / shares	$ 2.09
Ending balance \| $ / shares	$ 2.09

Equity-based Compensation - Com

Equity-based Compensation - Compensation expense (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2023	Mar. 31, 2022
Equity-based Compensation
Total equity-based compensation	$ 1,187	$ 1,001
Total unrecognized compensation cost related to options	$ 6,944
Weighted average period over which the unrecognized compensation cost is expected to be recognized	2 years
Research and development
Equity-based Compensation
Total equity-based compensation	$ 157	234
General and administrative
Equity-based Compensation
Total equity-based compensation	$ 1,030	$ 767

Net Loss per Share - Antidiluti

Net Loss per Share - Antidilutive effect (Details) - shares	3 Months Ended
Net Loss per Share - Antidilutive effect (Details) - shares	Mar. 31, 2023	Mar. 31, 2022
Net Loss per Share
Potentially dilutive common stock equivalents outstanding	4,465,876	5,107,974
Options issued and outstanding
Net Loss per Share
Potentially dilutive common stock equivalents outstanding	4,090,006	5,107,974
Restricted Stock Units
Net Loss per Share
Potentially dilutive common stock equivalents outstanding	375,870