The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||||||
| UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ACADIA PHARMACEUTICALS INC | COM | 004225108 | 15,633 | 370,000 | SH | OTR | 370,000 | 0 | 0 | ||
| AKERO THERAPEUTICS INC | COM | 00973Y108 | 8,830 | 416,495 | SH | OTR | 416,495 | 0 | 0 | ||
| AGENUS INC | COM NEW | 00847G705 | 9,800 | 4,000,000 | SH | OTR | 4,000,000 | 0 | 0 | ||
| ALLAKOS INC | COM | 01671P100 | 30,031 | 675,000 | SH | OTR | 675,000 | 0 | 0 | ||
| AMARIN CORP PLC | SPONS ADR NEW | 023111206 | 9,000 | 2,250,000 | SH | OTR | 2,250,000 | 0 | 0 | ||
| AMICUS THERAPEUTICS INC | COM | 03152W109 | 21,483 | 2,325,000 | SH | OTR | 2,325,000 | 0 | 0 | ||
| ANAPTYSBIO INC | COM | 032724106 | 18,369 | 1,300,000 | SH | OTR | 1,300,000 | 0 | 0 | ||
| ARCUS BIOSCIENCES INC | COM | 03969F109 | 42,818 | 3,084,883 | SH | OTR | 3,084,883 | 0 | 0 | ||
| ARGENX SE | SPONSORED ADR | 04016X101 | 26,346 | 200,000 | SH | OTR | 200,000 | 0 | 0 | ||
| ARTARA THERAPEUTICS INC | COM | 04300J107 | 4,590 | 199,567 | SH | OTR | 199,567 | 0 | 0 | ||
| ATRECA INC | CL A COM | 04965G109 | 28,691 | 1,733,583 | SH | OTR | 1,733,583 | 0 | 0 | ||
| AXSOME THERAPEUTICS INC | COM | 05464T104 | 8,825 | 150,000 | SH | OTR | 150,000 | 0 | 0 | ||
| BARCLAYS BK PLC | SHRT TRM ETN 48 | 06746P621 | 3,469 | 75,000 | SH | OTR | 75,000 | 0 | 0 | ||
| BARCLAYS BK PLC | PUT | 06746P951 | 13,875 | 300,000 | SH | Put | OTR | 300,000 | 0 | 0 | |
| BEIGENE LTD | SPONSORED ADR | 07725L102 | 113,877 | 925,000 | SH | OTR | 925,000 | 0 | 0 | ||
| BELLEROPHON THERAPEUTICS INC | COM | 078771300 | 1,083 | 98,809 | SH | OTR | 98,809 | 0 | 0 | ||
| BELLUS HEALTH INC NEW | COM NEW | 07987C204 | 17,715 | 1,775,000 | SH | OTR | 1,775,000 | 0 | 0 | ||
| BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 21,125 | 250,000 | SH | OTR | 250,000 | 0 | 0 | ||
| BLACK DIAMOND THERAPEUTICS I | COM | 09203E105 | 50,271 | 2,014,858 | SH | OTR | 2,014,858 | 0 | 0 | ||
| CABALETTA BIO INC | COM | 12674W109 | 11,434 | 1,566,361 | SH | OTR | 1,566,361 | 0 | 0 | ||
| CELLECTAR BIOSCIENCES INC | COM PAR | 15117F500 | 1,226 | 920,000 | SH | OTR | 920,000 | 0 | 0 | ||
| COMPUGEN LTD | ORD | M25722105 | 17,305 | 2,383,673 | SH | OTR | 2,383,673 | 0 | 0 | ||
| CYMABAY THERAPEUTICS INC | COM | 23257D103 | 2,960 | 2,000,000 | SH | OTR | 2,000,000 | 0 | 0 | ||
| DBV TECHNOLOGIES S A | SPONSORED ADR | 23306J101 | 27,576 | 7,034,598 | SH | OTR | 7,034,598 | 0 | 0 | ||
| DIREXION SHS ETF TR | DAILY S&P BIOTEC | 25460E539 | 17,600 | 1,250,000 | SH | OTR | 1,250,000 | 0 | 0 | ||
| ESPERION THERAPEUTICS INC NE | COM | 29664W105 | 30,742 | 975,000 | SH | OTR | 975,000 | 0 | 0 | ||
| GLOBAL BLOOD THERAPEUTICS IN | COM | 37890U108 | 12,773 | 250,000 | SH | OTR | 250,000 | 0 | 0 | ||
| GOSSAMER BIO INC | COM | 38341P102 | 22,178 | 2,185,000 | SH | OTR | 2,185,000 | 0 | 0 | ||
| IDEAYA BIOSCIENCES INC | COM | 45166A102 | 3,149 | 764,252 | SH | OTR | 764,252 | 0 | 0 | ||
| IMMUNOMEDICS INC | COM | 452907108 | 113,906 | 8,450,000 | SH | OTR | 8,450,000 | 0 | 0 | ||
| KADMON HLDGS INC | COM | 48283N106 | 26,003 | 6,205,882 | SH | OTR | 6,205,882 | 0 | 0 | ||
| KINIKSA PHARMACEUTICALS LTD | COM CL A | G5269C101 | 4,498 | 290,577 | SH | OTR | 290,577 | 0 | 0 | ||
| KODIAK SCIENCES INC | COM | 50015M109 | 7,155 | 150,000 | SH | OTR | 150,000 | 0 | 0 | ||
| KURA ONCOLOGY INC | COM | 50127T109 | 8,406 | 844,789 | SH | OTR | 844,789 | 0 | 0 | ||
| LA JOLLA PHARMACEUTICAL CO | COM PAR $.0001 2 | 503459604 | 3,741 | 890,700 | SH | OTR | 890,700 | 0 | 0 | ||
| LIFESCI ACQUISITION CORP | UNIT 03/31/2025 | 53228P208 | 3,000 | 300,000 | SH | OTR | 300,000 | 0 | 0 | ||
| MARINUS PHARMACEUTICALS INC | COM | 56854Q101 | 9,744 | 4,800,000 | SH | OTR | 4,800,000 | 0 | 0 | ||
| MATINAS BIOPHARMA HLDGS INC | COM | 576810105 | 6,889 | 11,478,634 | SH | OTR | 11,478,634 | 0 | 0 | ||
| MEI PHARMA INC | COM NEW | 55279B202 | 4,690 | 2,913,091 | SH | OTR | 2,913,091 | 0 | 0 | ||
| MEREO BIOPHARMA GROUP PLC | ADS | 589492107 | 2,561 | 2,450,543 | SH | OTR | 2,450,543 | 0 | 0 | ||
| MILESTONE PHARMACEUTICALS IN | COM | 59935V107 | 2,028 | 1,102,194 | SH | OTR | 1,102,194 | 0 | 0 | ||
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 135,719 | 1,765,560 | SH | OTR | 1,765,560 | 0 | 0 | ||
| MIRUM PHARMACEUTICALS INC | COM | 604749101 | 4,438 | 317,000 | SH | OTR | 317,000 | 0 | 0 | ||
| NEOLEUKIN THERAPEUTICS INC | COM | 64049K104 | 11,485 | 1,009,255 | SH | OTR | 1,009,255 | 0 | 0 | ||
| ODONATE THERAPEUTICS INC | COM | 676079106 | 92,863 | 3,363,377 | SH | OTR | 3,363,377 | 0 | 0 | ||
| PASSAGE BIO INC | COM | 702712100 | 29,662 | 1,883,315 | SH | OTR | 1,883,315 | 0 | 0 | ||
| PREVAIL THERAPEUTICS INC | COM | 74140Y101 | 13,691 | 1,123,105 | SH | OTR | 1,123,105 | 0 | 0 | ||
| REGENERON PHARMACEUTICALS | COM | 75886F107 | 65,919 | 135,000 | SH | OTR | 135,000 | 0 | 0 | ||
| RELMADA THERAPEUTICS INC | COM | 75955J402 | 10,233 | 300,000 | SH | OTR | 300,000 | 0 | 0 | ||
| REVOLUTION MEDICINES INC | COM | 76155X100 | 66,820 | 3,049,764 | SH | OTR | 3,049,764 | 0 | 0 | ||
| ROCKET PHARMACEUTICALS INC | COM | 77313F106 | 20,451 | 1,466,051 | SH | OTR | 1,466,051 | 0 | 0 | ||
| SAGE THERAPEUTICS INC | COM | 78667J108 | 44,014 | 1,532,510 | SH | OTR | 1,532,510 | 0 | 0 | ||
| SEATTLE GENETICS INC | COM | 812578102 | 46,152 | 400,000 | SH | OTR | 400,000 | 0 | 0 | ||
| SELECTA BIOSCIENCES INC | COM | 816212104 | 7,915 | 3,284,072 | SH | OTR | 3,284,072 | 0 | 0 | ||
| SOLID BIOSCIENCES INC | COM | 83422E105 | 3,661 | 1,531,872 | SH | OTR | 1,531,872 | 0 | 0 | ||
| SPRINGWORKS THERAPEUTICS INC | COM | 85205L107 | 56,049 | 2,075,905 | SH | OTR | 2,075,905 | 0 | 0 | ||
| SYNDAX PHARMACEUTICALS INC | COM | 87164F105 | 7,962 | 725,782 | SH | OTR | 725,782 | 0 | 0 | ||
| TRILLIUM THERAPEUTICS INC | COM NEW | 89620X506 | 16,463 | 4,075,000 | SH | OTR | 4,075,000 | 0 | 0 | ||
| UNIQURE NV | SHS | N90064101 | 36,318 | 765,400 | SH | OTR | 765,400 | 0 | 0 | ||
| XENON PHARMACEUTICALS INC | COM | 98420N105 | 6,804 | 600,000 | SH | OTR | 600,000 | 0 | 0 | ||
| ZOGENIX INC | COM NEW | 98978L204 | 4,328 | 175,000 | SH | OTR | 175,000 | 0 | 0 | ||
| ZYMEWORKS INC | COM | 98985W102 | 887 | 25,000 | SH | OTR | 25,000 | 0 | 0 | ||