Exhibit 10.27
AMENDED AND RESTATED
EXCLUSIVE LICENSE AGREEMENT
Between
THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITYOFARIZONA
And
CANCER PREVENTION PHARMACEUTICALS, INC.
THIS AMENDED AND RESTATEDEXCLUSIVE LICENSEAGREEMENT (this "AGREEMENT" ), effective as ofthedate of the last authorized signature affixed hereto, is by and between the Arizona Board of Regents,abody corporate of the State ofArizonaon behalf of The University of Arizona havingitsprincipal offices at Tucson, Arizona 85721("ARIZONA"),and Cancer Prevention Pharmaceuticals, Inc., a Delaware corporation having its principal office at 1760 E. River Road, Suite 250, Tucson, AZ 85718 ("LICENSEE"), successor in interest to Cancer Prevention Pharmaceutical, LLC, an Arizona limited liability company (“CPP LLC”).
PREAMBLE
Whereas, good and valuable inventionsjointlydeveloped at the University of California, Irvine ("UCI") andARIZONA areclaimed in Patent Rights, asdefined below;and
Whereas,inventors,who were employeesofARIZONA or UCI when the inventions were developed, have assigned, or shallassign,to their respective employers all of their right, title and interest in the inventions; and
Whereas,ARIZONAand The Regents of the University of California on behalf of theUniversityof California-Irvine, entered into an Inter-institutional Agreement, effective May 4 2001,thatauthorizes ARIZONA to act on behalf ofUCIinlicensingPatent Rights to a third party; and consequently in this Agreement,ARIZONAand UCI shallbereferred to collectively as"UNIVERSITIES";and
Whereas,LICENSEE and ARIZONA earlier entered into that certain Exclusive License Agreement made effective May 28, 2009 (the “Original Effective Date”) by which ARIZONA granted to LICENSEE anexclusivelicensetoPatent Rights for the use ofLicensedProduct and for the useful management of Licensed Product so that the inventions may bedevelopedand thebenefitsenjoyed by the public, which agreement was first amended by that certain First Amendment made effective September 16, 2009, and further amended by that certain Second Amendment made effective January 14, 2010, and further amended by that certain Third Amendment made effective April 12, 2010, and last amended by that certain Fourth Amendment made effective October 15, 2010 (collectively, the “Original License Agreement”); and
Whereas, for good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, LICENSEE and ARIZONA desire to amend the Original License Agreement and restate it in its entirety by way of this AGREEMENT, LICENSEE and ARIZONA hereby agree as follows:
| Arizona's First University - Since 1885. |  |
ARTICLE1
Definitions
| 1.1 | "Affiliate" means any entity that ownsorcontrols atleastfifty (50) percent of, or of which fifty(50)percentormore is owned or controlled, by LICENSEE. |
| 1.2 | “Develop” means to conduct scientific, technical and regulatory activities, including but not limited to pharmaceutical formulation development, pre-clinical, toxicological, process development for manufacturing, making regulatory filings and seeking regulatory approvals, and clinical studies, but does not include routine manufacturing. |
| 1.3 | "Effective Date" means the date of last signature by authorized representatives of the two parties affirming acceptance of the terms and conditions of this Agreement. |
| 1.4 | "Fields of Use" means all fields of use of the Technical Information and all fields of use of the inventions claimed in the Patent Rights. |
| 1.5 | "Inventor" means an inventor identified as such with respect to any of the Patent Rights. |
| 1.6 | "Licensed Product" means any product or method: |
| 1.6.1 | that is covered byPatentRights,tothe extent that the manufacture, use, sale, offer for sale or importation of such product or method would infringeanissued claim of Patent Rights (including, but not limitedto,inducementorcontributory infringement),but for the license granted to LICENSEE under this Agreement; or |
| 1.6.2 | the development, manufacturing, regulatory approval, labeling, use, marketing, sale or commercialization of which has been supported by, or benefitted from the access to, any Technical Information. |
| 1.7 | "Patent Rights" means: (a) the patents and patent applications identified inSchedule 1 attached to this Agreement, and any patents or patent applications that may be added to this Agreement (andExhibit A) by separate agreement of the Parties; (b) all divisional or continuation, in whole but not in-part, applications based on any of the foregoing; (c) any and all foreign applications corresponding to applications described in (a) or (b) above; (d) any and all issued and unexpired patents resulting from any of the applications described in (a) or (b) above; and (e) any and all issued and unexpired foreign patents, reissues, reexaminations, renewals, extensions or patent term restoration that may be based on any of the patents described in (a) or (d) above. |
| 1.8 | “SUBLICENSEE(S)” means any person or entity sublicensed, or granted an option for a sublicense, by LICENSEE under this Agreement. |
| 1.9 | "Technical Information" means UNIVERSITIES’ information and know-how made available toLICENSEE: |
| 1.9.1 | in tangible form, including without limitation, documented research data or information; clinical trial data including, but not limited to, data generated by NIH Clinical Trial # NCT00005882 and NCT00118365; or other written procedures or methods and protocols related to Licensed Products and Patent Rights;or |
| 1.9.2 | through services by ARIZONA or ARIZONA employees acting as consultants or on behalf of COMPANY in any capacity, with ARIZONA's approval that teach or transfer to LICENSEE ARIZONA know-how or information; or |
| 1.9.3 | through transfers of ARIZONA personnel associated with the project to LICENSEE or Affiliates. |
| 1.10 | "Territory" means worldwide. |
ARTICLE 2
Grant
| 2.1 | Grant of Rights. ARIZONA grants to LICENSEE an exclusive license to Develop, make, have made, import, have imported, use, market, sell, offer to sell, and distribute Licensed Product under the Patent Rights, and a non-exclusive license to Technical Information to Develop, use, label, market, sell, to make regulatory filings, and seek regulatory approval of, and otherwise commercialize Licensed Product within the Fields ofUseand in the Territory. ARIZONA shall not provide clinical trial data generated by NIH Clinical Trial #NCT00005882 and #NCT00118365 as described in Paragraph 1.8.1, to third parties for regulatory or commercial purposes. These rights are subject to the terms and conditions set forth herein. This grant does not relinquish UNIVERSITIES’ ownership in or rights to Licensed Product in the Fields ofUse,Patent Rights or Technical Information and does not grant to LICENSEE, by implication or otherwise, any rights to any other technologies owned, invented, or discovered by UNIVERSITIES, whether past, present or future. |
| 2.2 | Sublicenses.ARIZONA grants LICENSEE the right and power to issue sublicenses to third parties under the rights and licenses granted under Paragraph 2.1 above. LICENSEE’s right and power to issue sublicenses shall only be in effect as long as LICENSEE possesses an exclusive license under the Patent Rights under this Agreement. Any and all sublicense agreements granted by LICENSEE: (a) shall be consistent with this Agreement; (b) may not grant to SUBLICENSEE any rights broader or inconsistent with the rights set forth in this Agreement and; (c) to the extent applicable, must include all of the rights and obligations due ARIZONA in this Agreement, including the following Sections: 2.3, 2.4, 3, 5.1, 11, and 12. LICENSEE shall notify ARIZONA of each sublicense granted hereunder and provide ARIZONA with a copy of each sublicense, subject to the same obligations of confidentiality imposed on LICENSEE under the pertinent sublicense. LICENSEE shall collect and pay all fees due ARIZONA and guarantee all such payments due from SUBLICENSEEs.LICENSEE shall require SUBLICENSEEs to provide payments with financial reports to the extent required of LICENSEE hereunder, and LICENSEE shall collect and summarize for ARIZONA all such reports due from SUBLICENSEEs.LICENSEE shall monitor SUBLICENSEEs and assure license terms are met. |
| 2.3 | ARIZONA Reserved Rights.ARIZONA shall retain the right for itself to use the LicensedProductfor ARIZONA's educational and internal research purposes. ARIZONA shall retain the right to sublicense the rights for educational and internal research purposes to other institutions of higher education on behalf of any of the Inventors named in the patents who are employees of ARIZONA, in the event that said Inventor moves to that institution. However, nothing in this Paragraph 2.3 shall permit ARIZONA during the term of this Agreement to sell or lease embodiments of the inventions. |
| 2.4 | Publications. Nothing in this Agreement, except the provisions of Article 13·regarding Confidentiality of LICENSEE'sinformation,shall be deemed to limit the right of ARIZONA to publish, any and all technical data resulting from any research performed by ARIZONA, including but not limited to, research relating to the Licensed ProductorTechnical Information.ARIZONA will provide LICENSEE with all draft manuscriptsdescribingunpublished data at least forty five (45) days prior to submission for publication.If requested by LICENSEE in order topermitthe preparation and filing of appropriate patent applications,ARIZONA shall agree to an additional review period prior to submission of the draft manuscript to any outside entity, such additional period notto exceed forty-five (45) days. |
| 2.5 | Governing Laws.The use of Licensed Productshallbe subject to applicable county,state or federal laws, rules, and regulations governinguseof Licensed Product in or between any county, state or federal jurisdiction. |
| 2.6 | Grant Limitations.LICENSEE acknowledges that Licensed Product will not be used, marketed and/or sublicensed outside the Fields of Use or Territory. |
ARTICLE 3
GovernmentRights
| 3.1 | Rights of Sponsor. The development of this technology was sponsored in part by National Institute of Health Grant No.PO1 CA072008 and GrantNo. P50CA095060; and as aconsequence,this license is subject to overriding obligations tothe FederalGovernment under35U.S.C. §200-212 and applicable implementing regulations, as wellasthe payment-free provisions of Paragraph 3.2below. |
| 3.2 | Payment-free License to Government. Upon request of the U.S. Government, no payments may be paid or collected for use of Licensed Productbythe U.S. Government or any agency thereof, as provided for in the license to the government. |
ARTICLE 4
Fees and Warrants
| 4.1 | Fees.In consideration, in part,for the rights granted herein, LICENSEE shall pay the following fees: |
| 4.1.1 | One-Time, Non-Refundable, Non-Cancelable, Non-Creditable License Issue Fee. LICENSEE shall payARIZONA a one-time, non-refundable, non-cancelable, non-creditable license issue fee of five thousand dollars ($5,000) within fourteen (14) of the Original Effective Date.ARIZONA acknowledges that LICENSEE timely complied with the foregoing obligation in connection with the execution and delivery of the Original License Agreement. |
| 4.1.2 | Warrants. LICENSEE shall grantARIZONA warrants as partial consideration for this License in accordance with the warrantagreementattached hereto as Appendix A.ARIZONA acknowledges that LICENSEE timely complied with the foregoing obligation in connection with the execution and delivery of the Original License Agreement. |
| 4.1.3 | License Maintenance Fee.LICENSEE shall payARIZONA License Maintenance Fees as follows: |
1st through 4thanniversary of the Original Effective Date:$5,000
5th through 7th anniversary of the Original Effective Date: $10,000
8th through 10th anniversary of the Original Effective Date: $25,000
Annual maintenance fee payments will be fully creditable against any Milestone Fees due in the same calendar year. No annual maintenance fees are due after the 10th anniversary of the Original Effective Date.
| 4.1.4 | Milestone Fees. LICENSEE shallpayARIZONA Milestone Fees, asfollows: |
4.1.4.1For Licensed Productclaimedin Patent Rights identified in Group I of Schedule 1:
| a) | $25,000 due upon receipt of U.S. Food and Drug Administration ("FDA") marketing approvalthroughtheNDA(New Drug Application) process by LICENSEE, Affiliate,assignee or SUBLICENSEEfor Licensed Product in Fields ofUse for prevention or treatmentofFamilial Adenomatous Polyposis (FAP); and |
| b) | $50,000 due upon receipt of FDA marketing approval by LICENSEE, Affiliate, assignee or SUBLICENSEE forLicensedProduct in Fields of Use for prevention or treatment of colon polyps, adenomas or colorectal cancer. |
| 4.1.4.2 | For License Product claimed in Patent Rights identified in Group II of Schedule 1: |
$15,000 due upon receipt of FDA marketing approval, through the PMA (Premarket Approval) application process, by LICENSEE, Affiliate, assignee or SUBLICENSEE or approval by the Centers for Medicare & Medicaid Services (“CMS”) of a test under the Clinical Laboratory Improvement Amendments for use with such Licensed Product.
4.2Patent Maintenance and Related Costs. LICENSEE agrees to accept, and is hereby granted the corresponding rights and authority of, management and financial responsibilities for prosecution and maintenance of Patent Rights and of any other patent rights as the parties may subsequently agree will be included within the scope of the licenses granted hereunder. LICENSEE shall nominate, and ARIZONA shall promptly approve, which approval shall not be unreasonably withheld, conditioned or delayed, patent counsel to prosecute and maintain such Patent Rights. ARIZONA acknowledges that it has approved Parker Highlander PLLC as LICENSEE’s nominee for patent counsel. It is further agreed that LICENSEE shall instruct patent counsel to send to ARIZONA, at the address and contact points specified in Art. 9, Notices, copies of all proposed patent correspondence with the USPTO and foreign patent authorities at the time the same are communicated to LICENSEE. LICENSEE shall instruct patent counsel to take into consideration ARIZONA’s comments received reasonably in advance of the pertinent deadline when responding to a US or foreign patent office. ARIZONA and LICENSEE share a community of interest with regard to the prosecution of the Patent Rights and, accordingly, ARIZONA shall treat all communications from LICENSEE’s patent counsel as confidential attorney-client privileged communications.
If LICENSEE affirmatively elects to abandon prosecution or maintenance of a particular patent application or patent in a particular country, ARIZONA will be notified in sufficient time to assume responsibilities should ARIZONA decide to do so. LICENSEE shall bear all costs incurred in the maintenance or prosecution of the pertinent patent or patent application, as the case may be, until such time as the ARIZONA assumes responsibility for that patent prosecution, but in no event will LICENSEE be obligated to bear those costs incurred three months after the date of LICENSEE’s abandonment notice to ARIZONA. If LICENSEE intentionally abandons any particular patent application or issued patent as provided above, the licenses under Paragraph 2.1, Grant of Rights, shall terminate on the effective date of that abandonment, whereupon said application or issued patent shall no longer be considered part of licensed Patent Rights hereunder.
| 4.3 | Payments.Payments hereunder shall be made in United Statesdollars. |
| 4.4 | Fee Payment Schedule. LICENSEE shall pay all fees under Paragraph 4.1 annually within 30 days of December 31 of each calendar year. Each such payment shall be for the most recently completed calendar year. |
| 4.5 | Charge for Late Payment. In the event that fee paymentsarenot received when due, the LICENSEE shall pay additional interest charges at an annualrateof ten percent (10%).Interest shall be calculated from the date payment was due and until actually received byARIZONA. |
| 4.6 | Obligation to Pay Fees. If any patent or patent claim within Patent Rights is held invalidina final decision by a court of competent jurisdiction and lastresortfrom which no appeal has or can be taken, all obligation to pay fees based on that patent orclaimor any claim patentablyindistinct therefrom will be reduced by 50% as of the date of final decision. LICENSEE shall not, however, be relieved from paying full fees that accrued before the final decision, that are based on another patent or claim not involved in the final decision, or that are based onARIZONA 's property rights. |
ARTICLE 5
Reports andInspections
| 5.1 | Books and Records. LICENSEE shall maintainaccuratebooks and records, and, upon reasonable advance notice byARIZONA, LICENSEE's records shall be open for inspection byARIZONA for the purpose of verifyingtheaccuracy ofreports.LICENSEE shallkeep,and cause SUBLICENSEE(s) to keep, accurate recordsand booksshowing all transactions regarding the use of Licensed Product or sublicensing of Licensed Product and shall permit duly authorized agents ofARIZONA, during regular businesshours,to inspect records regarding payments dueARIZONA. In the event payment is in errorbyfive percent (5%) or more, LICENSEE shall pay all reasonable documented audit expenses. |
| 5.2 | Annual Reporting on Use of Licensed Product. After the first commercial use ofLicensed Product, LICENSEE shall provideARIZONA with an annual written report within 60 days after December 31 and June 30 of each year indicating: |
| 5.2.1 | Summary of sales of Licensed Product by LICENSEE, Affiliates, and assignees during the pertinent reported period and the reported sales by SUBLICENSEE(s) in reports received by LICENSEE during the pertinent reporting period; and |
| 5.2.2 | The payments due, if any,includingthe methodused tocalculate payments with respect to the sales reported in Paragraph 5.2.1 above. |
| 5.3 | Annual R & D Reporting. Thirty (30)daysafterDecember31 of each year following the Original Effective Date and continuing annually thereafter, LICENSEE shallsubmittoARIZONA a progress report covering LICENSEE' s activities relatedto development andtesting of Licensed Product and obtaining governmental approvals necessary for marketing and commercialuse.Progress reports are required for each Licensed Product until the first commercial use of any Licensed Product occurs in the United States and shall again be required if commercial use of any Licensed Product is suspended or discontinued. |
| 5.4 | Progress Reports. Progress reports submitted under Paragraph 5.3 shall include, but are not limited to, the following topics: currentscheduleof anticipated events or milestones, market plans for introduction of Licensed Products, a summary of the value of resources spent in the reporting period and summary of work completed. |
ARTICLE 6
Infringement
| 6.1 | Infringement Notification. The LICENSEE shall notifyARIZONA promptly ifany unauthorized use of Licensed Product or Technical Information comes to the attention of the LICENSEE.Notification of such infringement shall include reasonable details that would enableARIZONA to investigate and terminate such infringement, andARIZONA retains therightto terminate such infringement. |
| 6.2 | Pursuit of Infringers. Pursuant to this Agreement and to the provisions of 35U.S.C. 29 or other statutes, LICENSEE is empowered, and may extend that power to each SUBLICENSEE that is granted exclusive rights within a particular country or set of countries under the pertinent sublicense agreement (each, an “Exclusive SUBLICENSEE”): |
| 6.2.l | to bring suit in its own name, withoutexpense toARIZONA,and on its own behalf for infringement of presumably valid claims in PatentRights or infringement or misappropriation of the Technical Information;and |
| 6.2.2 | in any such suit, to enjoin infringementand to collectfor its use, damages, profits, and awards of whatever naturerecoverableforsuch infringement or misappropriation;and |
| 6.2.3 | in any suchsuit,with the prior writtenpermission ofARIZONA, such permission not to be unreasonably withheld,to settle any claim or suitforinfringementof Patent Rights exclusively licensed to LICENSEEunder thisAgreement or for infringement or misappropriation of the Technical Information. |
LICENSEE shall notify and seek input fromARIZONA of LICENSEE's intentiontofile suit prior to filing thereof.ARIZONA acknowledges that, as assignee of the Patent Rights and the Technical Information, it may be a necessary party to any suit or legal proceeding brought by LICENSEE or an Exclusive SUBLICENSEE concerning infringement of the Patent Rights or misappropriation of the Technical Information. In light of that,ARIZONA agrees to join in any such suit or legal proceeding in which the pertinent court or tribunal concludes thatARIZONA is a necessary party to that suit or legal proceeding. In that event, and ifARIZONA so requests, LICENSEE’s legal counsel must representARIZONA, at LICENSEE’s expense, in any consequent legal proceedings. If the suit or proceeding is brought by an Exclusive SUBLICENSEE, LICENSEE must cause the Exclusive SUBLICENSEE’s legal counsel to represent Arizona, at no expense to Arizona. If that legal counsel is unable to representARIZONA because of a conflict of interest or other bona fide reason,ARIZONA may engage other competent legal counsel, at LICENSEE’s expense of all of ARIZONA’s reasonable costs and subject to their reasonable approval, to representARIZONA in any such suit or legal proceeding. IfARIZONA does not wish to be represented by LICENSEE’s or the Exclusive SUBLICENSEE’s legal counsel for reasons other than a conflict of interest,ARIZONA may engage competent legal counsel of its own choosing to representARIZONA atARIZONA’s own expense.In the event that LICENSEE exercisesitsrights under this paragraph, then as between the parties, all recoveries had or obtained in such suit shall belong solely to LICENSEE with the exception of any earned fees payableto UNIVERSITY as set forth in this Agreement. LICENSEE agrees tokeepARIZONA reasonably apprised of thestatusand progress of any litigation.
| 6.3 | University Pursuit of lnfringers. In the eventthatsuit is initially brought byARIZONA under this Article,ARIZONA agrees that LICENSEE and its SUBLICENSEES mayjoinARIZONA as a party plaintiff in any such suit, to be controlled by ARIZONA, each to bear its own attorneys’ fees and costs. If neither LICENSEE nor any SUBLICENSEE joins as party plaintiff in such suit, then all recoveries had or obtained in such suit shall belong solely toARIZONA. If LICENSEE joins as party plaintiff in such suit, allocation of recoveries had or obtained in such suit shall be in accordance with terms to be negotiated by the involved parties, such allocation terms being reasonable and negotiated in good faith and subject to the terms of any pertinent sublicenses.ARIZONA’S allocation will reflect the degree in which the Patent Rights and Technical Information are utilized by the infringer (the “University Allocation”).If the involved parties are unable to agree upon the University Allocation on or before the date ninety (90) days after the date of termination of the pertinent legal proceeding, then either party may submit the matter to arbitration in accordance with the dispute resolution procedures set forth in Paragraph 14.10. |
| 6.4 | LICENSEE Pursuit ofinfringers. In any infringement actioncommencedunder this Article by LICENSEE or a SUBLICENSEE,the expenses in such action, including, but not limited to, costs, fees, attorney fees anddisbursements, as between the parties,shall be LICENSEE’s responsibility.. |
| 6.5 | UniversityCooperation.ARIZONA shall cooperate fully with LICENSEE in connection with any infringement action initiated by LICENSEE or a SUBLICENSEE under this Article, andARIZONA agrees promptly to provide reasonable access to all necessary documentsandto render reasonable assistance in response to a written request by LICENSEE. |
| 6.6 | Declaratory Judgment. In the event that a declaratory judgment alleging invalidity or non-infringement of any of the patents included in Patent Rights shall be brought against LICENSEE orraisedby way of counterclaim or affirmative defense in an infringement suit brought by LICENSEE or an Exclusive SUBLICENSEE under this Article, LICENSEE and each SUBLICENSEE, pursuant to this Agreement and to 35 U.S.C.29or other statutes, is empowered: |
| 6.7.1 | to defend the suit in its own name, atitsown expense, and on its own behalf, for presumably valid claims in such patents;and |
| 6.7.2 | in any such suit, to enjoin infringement and to collect for its use, damages, profits, and awards;of whatever nature recoverable for such infringement; and |
| 6.7.3 | in any such suit, with the prior writtenpermissionof ARIZONA, such permission not to be unreasonably withheld, tosettle any claimor suit for declaratoryjudgmentinvolvingPatentRights. |
Nothing inthisparagraph shall be construed aslimitingany rights granted toor retainedby eitherARIZONAor LICENSEE under this Article.
| 6.8 | Validity Challenge.In the event of a validity challenge brought by LICENSEE or an Affiliate,LICENSEE willpay the reasonable attorneys’ fees and costs ofARIZONAinsuch litigation as they accrue. In the event of a validity challenge brought by a SUBLICENSEE(thatdoes not otherwise payARIZONA directly pursuantto Paragraph2.2), if LICENSEE does not terminate the pertinent sublicense, thenLICENSEE willpay the reasonable attorneys’ fees and costs ofARIZONAinsuch litigation as they accrue. |
| 6.9 | Recovery of PunitiveDamages. In the event that LICENSEErecoverspunitive damagesin anyaction brought under this Article, LICENSEE shall pay toARIZONA15% of anyrecovery. |
| 6.10 | No Obligation or Limitations.Nothing contained within this Article or thisAgreement shallbe construed toobligateARIZONA to bring any suit or to enforce any rights under this Agreement. Additionally, nothing contained within this Article or this Agreement shall be construed to limit the abilityofARIZONA to bring any suitorto enforce any rights under thisAgreement. |
ARTICLE 7
Termand Termination
| 7.1 | Term. ThisAgreement shallbe in effect as of the Effective Date and shall continue until theexpiration of latest expiringPatent Rights. Upon expiration of the Patent Rights, the licenses and rights granted under this Agreement related to Technical Information, will be fully-paid, perpetual and irrevocable. |
| 7.2 | Terminationby LICENSEE. LICENSEE may terminate thisAgreementby givingARIZONA ninety(90) daysprior written notice and including in the notice a declarationthat LICENSEEis no longer,andhenceforthwillnot be, making commercial gain from the use of Patent Rights or TechnicalInformationintheFieldsof Use or in the Territory. |
| 7.3 | Termination byARIZONA. If LICENSEEbreaches any materialtermof thisAgreement,thenARIZONA may give written notice of thebreach;and, if LICENSEE failsto correct thebreach withinsixty (60)days of its receipt of the written notice,thenARIZONA shall have the right toterminatetheAgreement by written notice to LICENSEE. If exercised byARIZONA,this right supersedes the rights granted in Article 2(Grant). Forpurposes of this paragraph, and subject to Section 8.3 below, a breach of this Agreement shallincludefailure to fulfillLICENSEEmarketingrequirementsunder Art. 8 of this Agreement; or after the first commercial use, ceasing thecommercialuse ofLicensedProduct. |
| 7.4 | Automatic Termination.This Agreement will terminate automatically if, during the term of this Agreement,LICENSEE: |
| 7.4.1 | is generally unable to pay its debts as they become due; or |
| 7.4.2 | commits any act of bankruptcy; or |
| 7.4.3 | becomes insolvent; or |
| 7.4.4 | files a voluntary petition under any bankruptcy orinsolvencyact; or |
| 7.4.5 | has an involuntary petition under any bankruptcy or insolvency act filed against it which is not dismissed within ninety (90) days; or |
| 7.4.6 | offers any component of the Patent Rights for the benefit ofitscreditors; or |
| 7.4.7 | terminates its existence. |
| 7.5 | Effect ofTermination. Subject to Section 7.6, upon termination of this Agreement; LICENSEE shallimmediatelycease use of the rights granted herein. |
| 7.6 | Effect of Termination on Sublicenses.Upon termination of this Agreement pursuant to Section 7.3 or 7.4 above,each sublicense granted under this Agreement shall remain in effect, but subject to further action of the parties as specified in this Paragraph. If the agreement granting the sublicense pertains only to the Patent Rights and the Technical Information, then LICENSEE shall assign the sublicense toARIZONA for the exclusive benefit of theARIZONA, subject to any required written consent of the SUBLICENSEE to any such assignment and subject to the written consent ofARIZONA, which will be granted so long as the agreement to be assigned at the time of assignment is consistent with this Agreement (including without limitation sections 6.8, and 14.7 through 14.11), imposes obligations on SUBLICENSEE that are substantially similar to the obligations of LICENSEE as set forth in this Agreement, and does not contain provisions that theARIZONA is prohibited by law or ABOR policy from agreeing to. If the agreement granting the sublicense under this Agreement also grants rights and licenses with respect to intellectual property in addition to the Patent Rights and Technical Information (a “Blended IP Agreement”), then LICENSEE shall continue to be a party to the Blended IP Agreement and to administer it and be liable toARIZONA under its terms, but shall pay and assign over toARIZONA a portion of any consideration received under the Blended IP Agreement that reflects the degree in which the Patent Rights and Technical Information are utilized by the SUBLICENSEE in commercialization of products under the Blended IP Agreement (the “University Portion”). LICENSEE shall exercise its reasonable commercial efforts to cause the SUBLICENSEE under the Blended IP Agreement to make reports regarding and payments of the University Portion directly toARIZONA and/or to negotiate directly withARIZONA a separate agreement that covers the Patent Rights and Technical Information, and that terminates the rights and obligations under the Blended IP Agreement pertaining to the Patent Rights and Technical Information. Promptly after termination of this Agreement, LICENSEE andARIZONA will convene a meeting to determine the University Portion and LICENSEE must provide toARIZONA, under appropriate confidentiality obligations, any underlying information in LICENSEE’s possession or control that reasonably relates to that determination. If the parties are unable to agree upon the University Portion on or before the date ninety days after the date of termination of this Agreement, then either party may submit the matter to arbitration in accordance with the dispute resolution procedures set forth in Paragraph 14.10. Any rights or licenses granted under the Blended IP Agreement with respect to LICENSEE’s intellectual property rights shall be unaffected notwithstanding the provisions of this Paragraph. If, in any event, upon termination of this Agreement pursuant to Sections 7.3 or 7.4, a particular sublicense agreement is not either assigned toARIZONA or the payments are assigned toARIZONA, in either case as specifically set forth above, within ninety (90) date after the effective date of termination of this Agreement, then the applicable sublicense will terminate upon termination of this Agreement andARIZONA agrees to negotiate in good faith for a new license directly with the applicable SUBLICENSEE. |
| 7.7 | No Relief of Obligations Incurred Prior to Termination. Termination of theAgreementgranted hereunder by either party does not relieve the parties of obligations incurred prior tosuchtermination. |
| 7.8 | SurvivingTerms.Notwithstanding any termination or expiration ofthisAgreement, the provisions of Articles 11 [No Warranties], 12 [ Indemnification], and 13 [Confidentiality] shall survive and shall beenforceable accordingto the terms thereof. |
ARTICLE 8
DueDiligence
| 8.1 | Obligation to Commercialize.LICENSEE shall,usingbest business practice, diligently fill the market demands for Licensed Products within the Fields of Use and in the Territory. To that end,LICENSEEshall meet the developmental milestones described in this Article. |
| 8.2 | GovernmentApprovals. LICENSEE shall diligently endeavor to obtain all necessary governmentalapprovalsfor marketing of the first Licensed Product in any country of the Territory within ten (10) years of the OriginalEffectiveDate. |
| 8.3 | LICENSEEMarketing Obligations. LICENSEE shall market Licensed Product within the Fields ofUsewithinninety(90) days of regulatory approval by both the FDA of the Licensed Product for marketing and the CMS of any CLIA-compliant diagnostic test required by the labeling of the Licensed Product to be used in determining administration of the Licensed Product. It is acknowledged by the parties that development and marketing and sale of Licensed Products can be delayed by unforeseen and unusual consequences neither caused by nor under the control of LICENSEE, including by way of example, but not limitation,regulatory actions, safety concerns, recalls and the like. Should such delays cause LICENSEE to fail to complete any development activity or milestone within theallottedtime, or cause LICENSEE to suspend marketing or sale of any LICENSED PRODUCT, the periods allotted may be extended by mutual agreement, following sufficient documentation of such delays by theLICENSEE. |
| 8.4 | Should LICENSEE fail to complete any development activity or milestone within the allotted time under this Art.8, LICENSEE shall have the option to either a) payARIZONA $10,000 per year until the LICENSEE meets such obligation, such payment due within 30 days of receipt ofARIZONA 'sinvoice;or b) accelerate the payments under 4.1.4.1.(a).Should LICENSEE fail to meet obligations under this Art. 8 for more than three (3) consecutive years, that failure will constitute a material breach of this Agreement andARIZONA may elect to terminate this Agreement in accordance with Paragraph 7.3. |
ARTICLE 9
Notices
Any royalty or fee payment, notice, or other communication required or permitted to be made or to be given to either party under this Agreement shall be sufficiently made or given on the date of mailing if sent to such party by certified first class U.S.mail, postage prepaid, addressed to that party at its address set forth below.
If toARIZONA:
Tech Transfer Arizona
The University of Arizona
University Services Annex, 4th Floor
PO Box 210300A
Tucson, Arizona 85721-0300
Attn: UA98-023
Phone: 520-621-5000
Facsimile 520-626-4600
If to LICENSEE:
Mr. Jeffrey E. Jacob, CEO
Cancer Prevention Pharmaceuticals, Inc. 1760 E. River Road, Suite 250
Tucson, Arizona85718
Phone: 520-908-7774
Facsimile: 520-232-2191
ARTICLE 10
Assignment
| 10.1 | This Agreement may be assigned byARIZONA. This Agreement shall not be assigned by LICENSEE except (a) with the prior written consent ofARIZONA, which consent shall not be unreasonably withheld; or (b) as part of a sale or transfer of substantially the entire business of LICENSEE relating to operations which concern this Agreement. Assignment of this Agreement by LICENSEE shall become effective after written notice by LICENSEE toARIZONA including the following: |
| 10.1.1 | notice that assignment has been made; |
| 10.1.2 | name of the assignee; |
| 10.1.3 | assignee's acknowledgementof the terms and conditions of this Agreement; and |
| 10.1.4. | contact information necessary to update Article 9 (Notices). |
ARTICLE 11
No Warranties
| 11.1 | EXCEPT AS OTHERWISE EXPRESSLY SET FORTH IN THIS AGREEMENT,UNIVERSITIESMAKE NO REPRESENTATIONS AND EXTENDS NO WARRANTIES OF ANY KIND, EITHER EXPRESS OR IMPLIED, INCLUDING, BUT NOT LIMITED TO,WARRANTY OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE, ANDVALIDITY OF PATENTED RIGHTS CLAIMS, ISSUED OR PENDING.IT IS AGREED THAT LICENSEE ACCEPTS LICENSED PRODUCTS ON AN "AS IS" BASIS. |
| 11.2 | NOTHING IN THIS AGREEMENT, EITHER EXPRESS OR IMPLIED,OBLIGATESUNIVERSITIESEITHER TO BRING OR TO PROSECUTE ACTIONS OR SUITS AGAINSTTHIRD PARTIES FOR PATENT INFRINGEMENT OR TO FURNISH ANY KNOW-HOW OR TRADE SECRETS NOT PROVIDED INUNIVERSITIES’PATENT RIGHTS OR NOT EXPRESSLY REQUIRED UNDER THIS AGREEMENT. |
| 11.3 | IN NOEVENTSHALLUNIVERSITIESBE LIABLE FOR ANY INCIDENTAL,SPECIAL,OR CONSEQUENTIAL DAMAGES RESULTING FROM THE EXERCISE OF THIS LICENSE OR THE USE OF THE TECHNICAL INFORMATION OR LICENSED PRODUCTS. |
| 11.4 | NO WARRANTY OR REPRESENTATION IS MADE THAT ANYTHING MADE, USED, OR SOLD UNDER THE TERMS OF THIS AGREEMENT WILL BE FREE FROM INFRINGEMENT OF ANY THIRD PARTY PATENTS. |
| 11.5 | THIS AGREEMENT DOES NOT CONFER BY IMPLICATION, ESTOPPEL,OR OTHERWISE ANY LICENSE OR RIGHTS TO ANY OTHER PATENT OFUNIVERSITIESOTHER THAN PATENT RIGHTS AS EXPRESSLY STATED HEREIN, REGARDLESS OFWHETHER SUCH PATENTS ARE DOMINANT OR SUBORDINATE TO PATENT RIGHTS. |
ARTICLE 12
Indemnification
| 12.1 | Indemnification of Universities. LICENSEE shall indemnify, hold harmless and defendUNIVERSITIES, its officers,employees,and agents against any and all claims, suits, losses, damage,costs, fees, and expenses resulting from or arising out of the exercise of this Agreement. |
| 12.2 | Insurance. LICENSEE,at its sole cost and expense, shall insure its activities in connection with the work related to Licensed Product under this Agreement and obtain, keep in force, and maintain insurance as follows, or an equivalent program of self-insurance: |
| 12.2.1 | Comprehensive or commercial general liability insurance (contractual liability included) with its minimum limits as follows:Each Occurrence $1,000,000; Products/Completed Operations Aggregate $5,000,000;Personal and Advertising Injury $1,000,000; and General Aggregate (commercial form only) $5,000,000; or |
| 12.2.2 | LICENSEE may obtain and carry commercial general liability insurance with minimum limit of $1,000,000 per occurrence until first use in humans, including clinical trials. Theminimumlimit of LICENSEE' s Product Liability and General Aggregate insurance must beincreased to $5,000,000 before the first patient is enrolled in a clinicaltrial. |
| 12.2.3 | The coverage and limits specified above do not in any way limittheliability of the LICENSEE under this Agreement. The LICENSEE shall, upon ARIZONA’S written request, furnish ARIZONA withcertificates of insurance showing compliance with all requirements. Except as provided below, such certificates must: provide for thirty(30)day advance written notice to ARIZONA of any modification; indicate that UNIVERSITIES have been endorsed as anadditionalinsured under the coverage specified above; and includeaprovision that the coverage will be primary and will notrelate to nor will be excessoverany valid and collectable insurance or program of self-insurance carried or maintained by UNIVERSITIES. LICENSEE will not be obligated to require a SUBLICENSEE to obtain the foregoing endorsements if the SUBLICENSEE is not granted a right to sell Licensed Products in the United States and if the law or insurance practices of the jurisdiction of that SUBLICENSEE do not permit or provide for such an endorsement. |
| 12.3 | Notification ofClaimsor Suits. ARIZONA shall notify LICENSEEinwritingofany claim or suit brought against UNIVERSITIES in respect of which UNIVERSITIES intends toinvokethe provisions ofthisArticle. LICENSEE shall keep ARIZONA informed on a current basis ofitsdefense of anyclaimsunder this Article. |
ARTICLE 13
Confidentiality
| 13.1 | Obligationsof Confidentiality.ARIZONA or LICENSEE as receiving party("ReceivingParty'') shall safeguard confidential information disclosed by ARIZONA or LICENSEE("Disclosing Party") andmarked "Confidential" against disclosure to third parties with the same degree of careasitexercises withits owninformationof a similar nature.Receiving Party shall not usesuchdata, excepttoperformits obligationsunder this Agreement, and shall not disclose such datatoothers(except to its employees, agents, or consultantswho are bound to Receiving Partyby a likeobligation of confidentiality)withoutthe express written permission of Disclosing Party, exceptthat theReceivingPartyisnot prevented fromusingordisclosing any ofthedatathat: |
| 13.1.1 | Receiving Partycandemonstrate by written records was previously knownto it; or |
| 13.1.2 | is now or becomes in the future public knowledge other thanthroughacts oromissions of theReceiving Party; |
| 13.1.3 | islawfullyobtainedby Receiving Party from sources independent ofDisclosingParty; or |
| 13.1.4 | constitutes Technical Information disclosed and used pursuant to a sublicense granted by LICENSEE hereunder, but subject to suitable obligations of confidentiality. |
The secrecyobligationsof Receiving Party under these terms shall remain in effectfor five (5) years from the terminationdate of this Agreement.
| 13.2 | Receiptof ConfidentialInformation. The obligations of confidentialityandlimited use hereunderapplyto any confidential information of Disclosing Party provided to ReceivingPartyrelating tothe subjectmatterof this Agreement, whethersupplied under this Agreement or previously. |
| 13.3 | Exclusion. This Agreementitself cannot be Proprietary Information per the Arizona Public RecordsLawARS 39-121and ARS 41-1350. |
ARTICLE 14
Miscellaneous
| 14.l | Restriction on Use of Name.Nothing contained in this Agreement confers any right to use in advertising, publicity, or other promotional activities any name, trade name, trademark, or other designation of the University of Arizona or UCI (including contraction, abbreviation, or simulation of any of the foregoing) without express written permission of ARIZONA or UCI, as the case may be. |
| 14.2 | Entire Understanding. This Agreement embodies the entire understanding of the parties, and there are no other agreements or understandings, either express or implied, betweentheparties relating to the subject matter hereof. No amendment or modification of this Agreement shall bevalidor binding upon the parties unless made in writing and signed on behalf of each of the parties by their respective duly authorized officers or agents. |
| 14.3 | Headings. The headings and General Understanding of the several Articles are inserted for convenience of reference only and are not intended to be a part of or affect the meaning or interpretation of this Agreement. |
| 14.4 | ForeignReporting or Approval. LICENSEE shall notifyARIZONA if LICENSEE becomes aware that this Agreement is subject to any applicable U.S. or foreign government reporting or approval requirement. LICENSEE shall make all necessary filings and pay all costs including, but not limited to, fees, penalties, and all other out-of-pocket costs associated with such reporting or approval process. |
| 14.5 | ExportControl. If applicable, LICENSEE shall observe all applicable United States and foreign laws with respect to the use of Licensed Product and related technical data in foreign countries, including, without limitation, the Export Administration Regulations. |
| 14.6 | Enforceabilityof Terms. In case any of theprovisionscontained in thisAgreementis held to be invalid, illegal, or unenforceable in any respect, that invalidity, illegality, or unenforceability will not affect any other provisions of this Agreement, and this Agreement will be construed as if the invalid, illegal, or unenforceable provisionshadneverbeencontained in it. |
| 14.7 | Choice of Law.The terms and conditions of this Agreement shall be subject to and shall be construed and enforced in accordance with applicablelawsas interpreted by the courts of the State of Arizona. |
Paragraphs 14.8 through 14.11 are required by theStateof Arizona.
| 14.8 | Compliance.The parties shall comply with all applicable state and federal statutesandregulationsgoverningequal employment opportunity, non-discriminationand immigration. |
| 14.9 | ConflictofInterest. Pursuant to the provisionsofARS 38-511, ARIZONA may cancel thisAgreementby written notice to the parties if any person substantially involved in obtaining, drafting or procuring this Agreement for or on behalf of ARIZONA becomes an employee or consultant in any capacity of the other party/parties to this Agreement within three (3) years after the Effective Date. |
| 14.10 | Arbitration. The parties agree that should a dispute arise between them concerning this Agreement and no party seeks affirmative relief other than money damages in the amount of Fifty Thousand Dollars ($50,000) or less, exclusive of interest, costs and attorneys' fees, the parties shall submit the matter to arbitration pursuant to the Revised Uniform Arbitration Act, A.R.S §12-3001 et seq. (the “Act”), whose rules shall govern the interpretation, enforcement, and proceedings pursuant to this paragraph. Except as otherwise provided in the Act, the decision of the arbitrator(s) shall be final and binding upon the parties. |
| 14.11 | State Funding.The parties recognize that the performance by ARIZONA may be dependent upon the appropriation of funds by the State Legislature of Arizona. Should theLegislaturefail to appropriate the necessary funds, ARIZONA may cancel its future obligations underthisAgreement without further duty or obligation.ARIZONA agrees to notify LICENSEE as soon as reasonably possible after the unavailability of said funds comes to ARIZONA’s attention. |
| 14.12 | Performance of Provisions. The failure of any party hereto at any time or times to require performance of any provisions of this Agreement shall in no manner affect its right to enforce such provision at a later time. |
IN WITNESS WHEREOF, each party hereto has executed this Agreement in duplicate originals by their respective and duly authorized officers on the day and year below written.
ARIZONA BOARD OF REGENTS
on behalf of
THE UNIVERSITY OF ARIZONA
/s/ David Allen
By:_________________________
David Allen, VP,
Tech Launch Arizona
12/19/13
Date:____________________
CANCER PREVENTION PHARMACEUTICALS, INC.
Jeffrey E. Jacob
By:___________________________
Jeffrey E. Jacob, CEO
12/19/13
Date:______________________
SCHEDULE 1
Licensed Patents
I. DFMO and Sulindac Combination in Cancer Chemoprevention
| ISSUED PATENTS | | | |
| Country | Patent No. | Issue Date | Expiration Date |
| U.S. | 6,258,845 | 07/10/2001 | 3/26/2019 |
| II. Carcinoma Diagnosis and Treatment, Based on ODC1 Genotype | |
| ISSUED PATENTS | | | |
| Country | Patent No. | Issue Date | Expiration Date |
| U.S. | 8,329,636 | 12/11/2012 | 1/15/2031 |
| | | | |
| PATENT APPLICATIONS | | | |
| Country | Patent Appln. No. | Filing Date | |
| Australia | AU2010248803 | 05/14/2010 | |
| Canada | 2,761,946 | 05/14/2010 | |
| China | CN 2010080031983.5 | 05/14/2010 | |
| Euro | EP2430452 | 05/14/2010 | |
| Hong Kong | 12111787.0 | 05/14/2010 | |
| (registration of CN 2010080031983.5) | | | |
| Israel | IL0216369 | 05/14/2010 | |
| Japan | JP2012-511052 | 05/14/2010 | |
| U.S. | 13/709,753 | 12/10/2012 | |
| | (continuation of U.S. 8,329,636) | | |
| WIPO | WO 2010/132817 | 05/14/2010 | |
| III. Cancer Prevention and Treatment Methods Based on Dietary Polyamine Content | |
| ISSUED PATENTS | | | |
| Country | Patent No. | Issue Date | Expiration Date |
| All are pending as of the Effective Date. | | | |
| | | | |
| PATENT APPLICATIONS | | | |
| Country | Patent Appln. No. | Filing Date | |
| U.S. | 13/697,984 | 05/13/2011 | |
| Canada | 2,799,431 | 05/13/2011 | |
| Euro | EP 2,568,978 | 05/13/2011 | |
| Japan | JP2013-510342 | 05/13/2011 | |
| WIPO | WO 2011/143579 | 05/13/2011 | |
| | (based on U.S. 61/345,048 | 05/14/2010) | |
| | | | |
| IV. Predictive Markers for Polyamine Inhibitor Cancer Therapies | |
| ISSUED PATENTS | | | |
| Country | Patent No. | Issue Date | Expiration Date |
| All are pending as of the Effective Date. | | | |
| | | | |
| PATENT APPLICATIONS | | | |
| Country | Patent Appln. No. | Filing Date | |
| U.S. | 61/719,748 | 10/29/2012 | |
APPENDIXA
Limited LiabilityCompany Interest WarranttoPurchase
Interestof CancerPrevention Pharmaceutical,LLC
Warrant PurchaseAgreement
