PDS Biotechnology 8K Other Events | PDSB 11 Mar 21

Exhibit 99.2

Nasdaq: PDSBDeveloping powerful, safe, versatileimmunotherapies CORPORATE OVERVIEW Frank Bedu-Addo Ph.D. President & CEO MARCH 2021

2 Forward-Looking Statements This presentation contains forward-looking statements about PDS Biotechnology Corporation (“PDSB”), and its businesses, business prospects, strategies and plans, including but not limited to statements regarding anticipated pre-clinical and clinical drug development activities and timelines and market opportunities. All statements other than statements of historical facts included in this presentation are forward- looking statements. The words “anticipates,” “may,” “can,” “plans,” “believes,” “estimates,” “expects,” “projects,” “intends,” “likely,” “will,” “should,” “to be,” and any similar expressions or other words of similar meaning are intended to identify those assertions as forward-looking statements. These forward-looking statements involve substantial risks and uncertainties that could cause actual results to differ materially from those anticipated.Factors that may cause actual results to differ materially from such forward-looking statements include those identified under the caption “Risk Factors” in the documents filed with the Securities and Exchange Commission from time to time, including its Annual Reports on Form 10-K, Quarterly Reports on Form 10-Q and Current Reports on Form 8-K. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date of this presentation. Except to the extent required by applicable law or regulation, PDSB undertakes no obligation to update the forward-looking statements included in this presentation to reflect subsequent events or circumstances.

Nasdaq: PDSB 3 PDS Biotech’s Versamune®-based immunotherapies promote a powerful in The most significant barrier to effective immunotherapy has been their inability to promote adequate CD8+ killer T-cell responses in vivo resulting in diminished efficacy vivo tumor-specific CD8+ killer T-cell responseVersamune®-based therapies also:Generate a strong CD8+ T-cell memory response resulting in long-lasting efficacyGenerate potency without systemic side effectsAre versatile and shown to be effective on their own or in combination with other drug to improve their efficacy

Nasdaq: PDSB Nasdaq: PDSB PDS Biotech is a clinical stage biotechnology company developing a pipeline of immunotherapies based on the proprietary Versamune® platform 4 NCI-initiated phase 2 HPV-cancer trial surpassed initial efficacy requirement prompting expansion to full enrollmentNovel COVID-19 vaccine being developed in Brazil with consortium partnersMCTI, Brazil to fund COVID-19 vaccinemanufacturing scale up & clinical trialsDemonstrated to work with a wide array of oncogenes and viral antigensMultiple composition and application patents valid through mid-2030s Biopharma developing novel cancer treatments and T-cell-activating vaccine candidates for infectious diseasesThree phase 2 oncology clinical trials in progress to initial data releases in 2021Clinical partnerships with Merck, MDAnderson and National Cancer Inst.~15 employees with headquarters in Florham ParkDebt free with approximately $33.5M in cash as of 9/30/20 VERSAMUNE® PLATFORM CORPORATE OVERVIEW

Nasdaq: PDSB Nasdaq: PDSB PDS Biotech’s robust Versamune®-based pipeline is being developed in partnership with the leaders in immuno-oncology and infectious disease 5 Reference: Data on file. * * *Consortium of PDS Biotech, Farmacore and Blanver. Funding provided by The Ministry of Science, Technology and Innovation of Brazil (MCTI)

Nasdaq: PDSB Nasdaq: PDSB PDS Biotech executive team has demonstrated success in the development and commercialization of leading pharmaceutical products 6 Senior executive experience with management of strategy and execution at both large pharma and biotechsNotable drug development:Abelcet® (Liposome Company/ Elan) PEG-Intron® (Schering-Plough/ Merck) Frank Bedu-Addo, PhDChief Executive Officer Co-founder>35 years of drug development experienceIn-depth experience with biotech drug discovery, product development and manufacturing Gregory Conn, PhDChief Scientific Officer >30 years of translational clinical research experienceFormer Director of Clinical Research at National Cancer Institute Center for Cancer Research (Cancer Vaccine Branch) Lauren V. Wood, MDChief Medical Officer Senior executive experience with over 20 years of experience in high tech companies In-depth experience with M&A transactions, capital markets, business development and investor relations Seth Van Voorhees, PhDChief Financial Officer

Introduction to the Versamune® Platform

Nasdaq: PDSB Nasdaq: PDSB Versamune® is designed to induce a robust and targeted anti-tumor response in vivo when administered with a tumor-associated antigen 8 Reference: Gandhapudi SK, et al. 2019. Antigen priming with enantiospecific cationic lipid nanoparticles induces potent antitumor CTL responses through novel induction of a Type I IFN response. J Immunol. 202 (12): 3524-3536.Smalley Rumfield C et al.. 2020.Immunomodulation to enhance the efficacy of an HPV therapeutic vaccine. J. for ImmunoTherapy of Cancer 8:e000612. Promotes uptake of vaccine or immunotherapy and entry into lymph nodes Promotes antigen processing and presentation to T-cells via MHC I and II pathways Activates Type I Interferon pathway, enabling a powerful anti- tumor killer CD8+ T-cell response Versamune® + Tumor- associated proteins (antigens)

Nasdaq: PDSB Nasdaq: PDSB Greater quantity and quality of Versamune®-induced killer T-cells may result in unique ability to eradicate HPV-positive tumors after a single dose 9 Single treatment dose Results typical of current top clinical-stage HPV cancer vaccines Tumor rechallenge at Day 60; complete and sustained cure of cancer *Adjuvant = cytokine GMCSFReferences: J. Immunology, 2019 (202), 1215; Studies in TC-1 tumor model with other immunotherapies reported in: Vaccine 2009, January 14, 27 (3): 431; Science Translational Medicine 2016, 13 April, Vol 8 Issue 334; Vaccine 2009, September 25, 27 (42): 5906. 0 50 100 200150 250 Adjuvant* + MUC1 4-Combo Adjuvant Antigen + MUC1 Antigen Versamune + MUC1 Antigen # of Antigen-Recognizing T-CellsIFN-γ Spot Forming Cells/1X106 Spleen Cells Induced a >10-fold number of highly potent T-cells and eradication of HPV-positive tumors after a single dose in preclinical studies500450400350(PDS0101)300 (PDS0103)Polyfunctional T-Cells Monofunctional T-Cells

Nasdaq: PDSB Phase 1 clinical trial: Powerful in-vivo CD8+ T-cell response results in regression of CIN cervical lesions supported continued clinical studies 10 * When treated with selected human clinical trial dosage (1mg and 3mg Versamune®)Nasdaq: PDSB References: L. Wood et al. A Novel Enantio-Specific Cationic Lipid R-DOTAP + HPV16 E6 & E7 Antigens Induces Potent Antigen-Specific CD8+ T Cell Responses In-Vivo in Subjects with CIN and High-Risk Human Papillomavirus Infection. Nov 8, 2019. SITC. Presentation O17. Complete lesion regression Partial regression (cytology only) Non responders Most patients infected with multiple strains of HPV CIN lesion regression at 1-3 months 60% 20% 20% 0 200 400 600 800 1000 1200 Pre-treatment baseline Versamune® + HPV16 Antigen (PDS0101)Interferon-γ # of Antigen-Recognizing T-Cells Granzyme-b Phase 1 trial results showed no serious or dose-limiting toxicities Overcomes key limitation of immuno-oncology: > 20-fold increase in circulating dual INF-γ & Granzyme-binducing killer T-cells vs. pre-treatment at day 14 led to rapid clearance of lesions*

Nasdaq: PDSB Versamune®-based Immunotherapies* Checkpoint Inhibitors Traditional Cancer Vaccines CAR-T Induction of high levels of active CD8+ (killer) T-cells   Induction of high levels of CD4+ (helper)T-cells    Ability to overcome tumor immune suppression   Induction of long-term memory CD8+ T-cells  No dose limiting toxicities   Initial data suggests Versamune® possesses the key characteristics of a safe and effective immunotherapeutic treatment *Reference: J. Immunology, 2019 (202), 1215; PDS0101 clinical trial report (CSR U10-02-11-001) 11

PDS0101 Phase 2 Clinical Development

Nasdaq: PDSB Nasdaq: PDSB Combinations of PDS0101 with FDA-approved standard of careFirst line treatment of recurrent/metastatic HPV-positive head and neck cancerCombination with Keytruda®Treatment of advanced localized cervical cancerCombination with chemoradiotherapy 13 Novel combinations of PDS0101 with promising, investigational immunotherapeutic agentsTreatment of advanced HPV-associated cancers (anal, cervical, vaginal, head and neck etc.)Triple combination with Bintrafusp-alpha (bi- functional checkpoint inhibitor - M7824) and NHS-IL12 (antibody conjugated immuno- cytokine) Clinical strategy: Develop PDS0101 in combination with established therapies for rapid proof-of-concept and risk mitigation

Indication Patients with advanced HPV-associated cancer who have failed prior treatment Clinical Agents M7824: Bifunctional fusion protein - checkpoint inhibitor + TGF-b “TRAP” (ORR ~30%)NHS-IL12: Antibody-conjugated immuno-cytokinePDS0101: Versamune®-based immunotherapy generating HPV-specific CD8+ T-cells Study goals Group 1: Objective response rate (ORR) in checkpoint inhibitor (CPI) naïve patients Group 2: ORR in patients who have failed checkpoint inhibitor therapy (CPI refractory) Timing Full enrollment of 45 patients triggered following achievement of objective response in ≥ 3 checkpoint inhibitor naive patientsTrial completion expected in Q1 2022 Trial Sponsor Nasdaq: PDSB Nasdaq: PDSB Phase 2 investigator-initiated clinical trial evaluating the combination of PDS0101, M7824 and NHS-IL12 in advanced HPV-associated cancer 14 Confirmation that PDS0101 enhances the therapeutic benefit of M7824 & NHS IL-12 may lead to expanded evaluation in several cancers with PDS0102-0104

Nasdaq: PDSB Nasdaq: PDSB 15 M7824 (bi-functional checkpoint inhibitor)+ NHS-IL12 (immuno-cytokine)Tumor Regression: 8/16 (50%)T-cell Clones: 18 PDS0101 + M7824 + NHS-IL12Tumor Regression: 13/17 (76%)T-cell Clones: 3 *Reference: Smalley Rumfield C, Pellom ST, Morillon II YM, et al; Journal for ImmunoTherapy of Cancer 2020; 8:e000612. doi: 10.1136/jitc-2020-000612 In a preclinical model, PDS0101 demonstrated enhanced ability to train tumor-specific T-cells effective in infiltrating and killing tumors Red – CD8+ (killer) T-cells Green – CD4 + (helper) T-cells T-cell clones per 25% of TCR repertoire (Average)

Nasdaq: PDSB Nasdaq: PDSB 16 PDS Biotech-sponsored phase 2 trial evaluating the combination of PDS0101 and KEYTRUDA for first-line treatment of HPV-associated metastatic/recurrent head and neck cancer Indication First line treatment of patients with HPV-associated head and neck cancer whose cancerhas spread or returned Clinical Agents KEYTRUDA (Standard of Care): Anti-PD1 checkpoint inhibitor (ORR ~20%)PDS0101: Versamune®-based immunotherapy generating HPV-specific CD8+ and CD4+ T-cells Study goals Objective response rate (ORR) and overall survival (OS) Timing Preliminary data – Q4 2021/Q1 2022, ORR in first 20 patients (efficacy in 7 of 38 required to enroll all 96 patients) Trial Partner Confirmation that PDS0101 enhances the therapeutic benefit of checkpoint inhibitors could expand evaluation of Versamune®-based therapies in multiple cancer indications

Nasdaq: PDSB Nasdaq: PDSB 17 A Phase 2, investigator-initiated clinical trial evaluating PDS0101 in combination with chemoradiation therapy in patients with advanced cervical cancer Indication Treatment of patients with locally advanced cervical cancer – Stages IB3-IVA Clinical Agents Chemoradiotherapy (CRT – Standard of Care): Cisplatin & radiation therapy PDS0101: Versamune®-based immunotherapy generating HPV-specific CD8+ and CD4+ T-cells Study goals Rate of regression in patients with primary tumor ≥5cm Timing Preliminary data – Q4 2021/Q1 2022 – Rate of complete response by PET-CT at 6 monthsand rate of tumor volume reduction by MRI at 30-40 days from start of treatment Trial Sponsor Safety and enhanced efficacy could lead to broad applications of Versamune®-based immunotherapies in combination with chemotherapy or CRT to treat multiple cancers

Nasdaq: PDSB Nasdaq: PDSB Studies are designed to demonstrate efficacy and broad applicability of PDS0101 and the Versamune® T-cell activating platform 18 Potential to enhance anti-cancer efficacy of various cancer treatments: Combinations with checkpoint inhibitors, chemotherapy and novel therapies may demonstrate Versamune®’s versatility. Broad potential for additional partnerships: Successful phase 2 studies with PDS0101 and PDS0203 could enable a broad pipeline of Versamune®-based products containing various antigens. Potential to treat all types of HPV-cancer: PDS0101 Phase 2 clinical studies address all types of HPV-associated cancers. Potential applications beyond oncology: PDS0203 COVID-19 phase 1/2 trials may demonstrate protection and induce durable T-cell responses against conserved regions of mutating viruses.

PDS0203 Phase 1/2 Clinical Development

Nasdaq: PDSB Nasdaq: PDSB Mt. Sinai data shows Versamune® promotes induction of neutralizing antibodies with lowest doses of SARS-CoV-2 antigen1 20 1Reference: Sun et al. 2020. Vaccines Volume 8, Issue 42Reference: Data on file PDS Biotech generated data shows induction of SARS-CoV-2 specific CD8+ T-cells with Versamune®2 Preclinical studies show powerful induction of long-lasting polyfunctional CD8+ andCD4+ anti-SARS-CoV-2 T-cells Developing a Versamune®-based COVID-19 vaccine candidate with the goal of promoting CD8+ T-cell responses and neutralizing antibodies

Nasdaq: PDSB Development of PDS0203 may offer potential advantages as a second generation COVID-19 vaccine May be effective against multiple COVID-19 variantsDemonstrated induction of killer CD8+ and helper CD4+ T cells that can target less variable regions of the SARS-CoV-19 virus and may be effective against currently circulating variants.May grant long-lasting immunityDemonstrated induction of long-lasting, virus-specific memory T-cells necessary for longer term protection.High potential for safetyPDS0203 is a subunit vaccine, and does not require the use of attenuated viruses, traditional adjuvants, DNA or RNA. Versamune®-based vaccines have shown no serious or dose limiting reactions. 21

Looking Forward

Nasdaq: PDSB Nasdaq: PDSB 23 Approximately 43,000 patients are diagnosed with HPV-associated cancers annually in the USIncidence rate is growing despite increased use of HPV preventative vaccinesSignificant unmet medical need across the spectrum of HPV-associated cancerExisting immunotherapies cost$120,000+ annually per patient2 1Markowitz et al. 2016. Centers for Disease Control and Prevention. 2018.2Hernandez et al. 2018. American Journal of Managed Care Volume 24, Issue 2; Company Research Females (24,391) Males (18,280) US annual HPV-associated cancer incidence1 PDS0101 is designed to treat cancers caused by human papillomavirus (HPV)

Nasdaq: PDSB Consortium has received a commitment of up to ~US$60 million from MCTI, Brazil to support phase 1-3 clinical development and manufacturing scale-upPhase 1/2 study anticipated to start in Q2/Q3 of 2021 pending approval from Anvisa, Brazilian regulatory agencyPending results, PDS0203 could be commercially available in Brazil in 2023Initial target market – Latin America ~ 650 million people (Brazil ~213 million people)1Based on public information, COVID-19 vaccine prices range from $20-74 for a two-dose regimen2 PDS0203 may offer another option to address the COVID-19 global health crisis 1The World Population Review. 2021.2Comparing COVID-19 Vaccines: Timelines, Types and Prices, BioSpace, 2/8/21; Company Research 24

Nasdaq: PDSB Versamune® has demonstrated the potential for immunological compatibility with a wide array of tumor and pathogenic antigens Reference: Clin Cancer Res. 2009 Sep 1;15(17):5323-37. doi: 10.1158/1078-0432.CCR-09-0737 Today, 4 tumor antigens are being utilized with the Versamune® platform, more than 75 tumor antigens have been identifiedWe are currently progressing two Versamune®-based infectious disease vaccines, one for SARS-COVID-19, and one for universal influenzaVersamune®’s unique flexibility means it may work well with a wide range of identified tumor and pathogenic antigensPotential to continuously expand development of Versamune®-based products through partnerships and licensing 25

Nasdaq: PDSB Nasdaq: PDSB Projected milestones through mid-2022* *Based on current enrollment and forecast modeling as of February 2021. Subject to change.**Consortium funding provided by MCTI, Brazil 4Q22 3Q22 2Q22 1Q22 4Q21 3Q21 2Q21 1Q21 Preliminary efficacy Data from advanced HPV-associated cancer trial (NCI)Interim Data from HPV- associated Cancer trial (NCI) expectedPreliminary Data from ImmunoCerv combo trial (MD Anderson) expectedPotential interim data from VERSATILE-002 (Keytruda combo)Completion of HPV-associated cancer trial (NCI)Initiation of Phase 1/2 COVID clinical trial of PDS0203Initiation of Phase 3 COVID clinical trial of PDS0203Efficacy data from Phase 3 COVID clinical trial of PDS0203 PDS0101 PDS0203** 26 PDS Biotech Funded Clinical Trials Partner Co-Funded Clinical Trials

Nasdaq: PDSB Nasdaq: PDSB Rapid commercialization strategy 27 Promising early data in both oncology and infectious disease: Early clinical data and preclinical data suggest potential efficacy, safety and versatility of the Versamune® platformNear-term milestones: PDS0101 preliminary efficacy data anticipated in Q2 2021 and PDS0203 safety and immunogenicity data projected in Q4 2021/Q1 2022Validation of approach: All three on-going phase 2 clinical trials supported and partnered with leading and top-tier institutions in the field of cancer and immuno-oncologyCommercialization path: Anticipated commercialization of PDS0203 in Brazil in 2023 and clinical studies demonstrating enhancement of FDA-approved anti-cancer products may offer rapid path to marketRapid adoption strategy: Evaluation of PDS0101 in combination with standard of care in multiple HPV- associated cancers Potential Advantages and Differentiators

Nasdaq: PDSBDeveloping powerful, safe, versatileimmunotherapies

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