| Document and Entity Information | May 17, 2022 |
| Cover [Abstract] | |
| Document Type | 8-K |
| Amendment Flag | false |
| Document Period End Date | May 17, 2022 |
| Entity Registrant Name | PDS BIOTECHNOLOGY CORPORATION |
| Entity Incorporation, State or Country Code | DE |
| Entity File Number | 001-37568 |
| Entity Tax Identification Number | 26-4231384 |
| Entity Address, Address Line One | 25B Vreeland Road |
| Entity Address, Address Line Two | Suite 300 |
| Entity Address, City or Town | Florham Park |
| Entity Address, State or Province | NJ |
| Entity Address, Postal Zip Code | 07932 |
| City Area Code | 800 |
| Local Phone Number | 208-3343 |
| Written Communications | false |
| Soliciting Material | false |
| Pre-commencement Tender Offer | false |
| Pre-commencement Issuer Tender Offer | false |
| Entity Emerging Growth Company | false |
| Entity Central Index Key | 0001472091 |
| Title of 12(b) Security | Common Stock, par value $0.00033 per share |
| Trading Symbol | PDSB |
| Security Exchange Name | NASDAQ |
