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Exhibit 23.1
Consent of Independent Registered Public Accounting Firm
We consent to the incorporation by reference in the Registration Statement on FormS-8 (FileNo. 333-199046) and the Registration Statements on FormS-3 (File Nos.333-206057,333-206786 and333-211748) of our report dated March 15, 2017, with respect to the financial statements of ContraFect Corporation included in this Annual Report(Form 10-K) for the year ended December 31, 2016.
/s/ Ernst & Young LLP
MetroPark, New Jersey
March 15, 2017