Revance Therapeutics (RVNC) 10-Q 13 Aug 14 2014 Q2 Quarterly report Financial data

Document_and_Entity_Informatio

Document and Entity Information	6 Months Ended
	Jun. 30, 2014	Aug. 01, 2014
Document And Entity Information [Abstract]	'	'
Document Type	'10-Q	'
Amendment Flag	'false	'
Document Period End Date	30-Jun-14	'
Document Fiscal Year Focus	'2014	'
Document Fiscal Period Focus	'Q2	'
Entity Registrant Name	'Revance Therapeutics, Inc.	'
Entity Central Index Key	'0001479290	'
Current Fiscal Year End Date	'--12-31	'
Entity Filer Category	'Non-accelerated Filer	'
Entity Common Stock, Shares Outstanding	'	23,493,472

Condensed_Consolidated_Balance

Condensed Consolidated Balance Sheets (Unaudited) (USD $)	Jun. 30, 2014	Dec. 31, 2013
In Thousands, unless otherwise specified
CURRENT ASSETS	'	'
Cash and cash equivalents	$203,308	$3,914
Restricted cash, current portion	75	75
Prepaid expenses and other current assets	3,175	825
Total current assets	206,558	4,814
Property and equipment, net	16,324	14,315
Restricted cash, net of current portion	435	510
Other non-current assets	'	3,006
TOTAL ASSETS	223,317	22,645
CURRENT LIABILITIES	'	'
Accounts payable	2,687	5,526
Accruals and other current liabilities	5,033	4,161
Deferred revenue, current portion	'	83
Derivative liabilities associated with convertible notes, current portion	'	4,890
Derivative liabilities associated with Medicis settlement, current portion	'	6,684
Financing obligation, current portion	331	'
Convertible notes, current portion	'	12,157
Notes payable, current portion and discount	10,714	10,702
Common stock warrant liability	'	3,358
Total current liabilities	18,765	47,561
Convertible preferred stock warrant liability	'	1,233
Financing obligation, net of current portion	703	'
Note payable, net of current portion and discount	0	2,632
Derivative liabilities associated with Medicis settlement, net of current portion	1,714	1,610
Deferred rent	3,627	3,176
TOTAL LIABILITIES	24,809	56,212
Commitments and Contingencies (Note 9)	'	'
Convertible preferred stock, par value $0.001 per share - 5,000,000 shares and 145,010,269 shares authorized as of June 30, 2014 and December 31, 2013, respectively; 0 shares and 8,689,999 shares issued and outstanding as of June 30, 2014 and December 31, 2013, respectively (aggregate liquidation preference of $0 and $215,264 as of June 30, 2014 and December 31, 2013, respectively)	'	123,982
STOCKHOLDERS' EQUITY (DEFICIT)	'	'
Common stock, par value $0.001 per share - 95,000,000 and 224,000,000 shares authorized as of June 30, 2014 and December 31, 2013, respectively; 23,493,472 and 260,789 shares issued and outstanding as of June 30, 2014 and December 31, 2013, respectively	23	'
Additional paid-in capital	429,093	38,331
Accumulated deficit	-230,608	-195,880
TOTAL STOCKHOLDERS' EQUITY (DEFICIT)	198,508	-157,549
TOTAL LIABILITIES, CONVERTIBLE PREFERRED STOCK AND STOCKHOLDERS' EQUITY (DEFICIT)	$223,317	$22,645

Condensed_Consolidated_Balance1

Condensed Consolidated Balance Sheets (Unaudited) (Parenthetical) (USD $)	Jun. 30, 2014	Dec. 31, 2013
In Thousands, except Share data, unless otherwise specified
Statement Of Financial Position [Abstract]	'	'
Convertible preferred stock, par value	$0.00	$0.00
Convertible preferred stock, shares authorized	5,000,000	145,010,269
Convertible preferred stock, shares issued	0	8,689,999
Convertible preferred stock, shares outstanding	0	8,689,999
Convertible preferred stock, aggregate liquidation preference	$0	$215,264
Common stock, par value	$0.00	$0.00
Common stock, shares authorized	95,000,000	224,000,000
Common stock, shares issued	23,493,472	260,789
Common stock, shares outstanding	23,493,472	260,789

Condensed_Consolidated_Stateme

Condensed Consolidated Statement of Operations and Comprehensive Loss (Unaudited) (USD $)	3 Months Ended		6 Months Ended
In Thousands, except Share data, unless otherwise specified	Jun. 30, 2014	Jun. 30, 2013	Jun. 30, 2014	Jun. 30, 2013
Revenue	$75	$75	$233	$150
Operating expenses:	'	'	'	'
Research and development	8,110	7,782	15,661	15,308
Sales, general and administrative	4,857	3,641	8,950	5,866
Total operating expenses	12,967	11,423	24,611	21,174
Loss from operations	-12,892	-11,348	-24,378	-21,024
Interest income	1	2	4	2
Interest expense	-267	-490	-10,108	-13,115
Loss on settlement of preferred stock warrant	'	'	-1,356	'
Other income (expense), net	-68	-4	-68	-2
Net and comprehensive loss	-13,302	-11,829	-34,728	-33,486
Net income (loss) attributable to common stockholders:	'	'	'	'
Basic	-13,302	-15,750	-34,728	1,357
Diluted	-13,302	-15,750	-34,728	5,689
Net income (loss) per share attributable to common stockholders:	'	'	'	'
Basic	($0.69)	($75.25)	($2.26)	$6.56
Diluted	($0.69)	($75.25)	($2.26)	$5.72
Weighted-average number of shares used in computing net income (loss) per share attributable to common stockholders:	'	'	'	'
Basic	19,380,934	209,307	15,361,215	206,751
Diluted	19,380,934	209,307	15,361,215	994,239
Medicis settlement [Member]	'	'	'	'
Operating expenses:	'	'	'	'
Change in fair value of derivative liabilities	-76	-221	-493	-221
Convertible preferred stock [Member]	'	'	'	'
Operating expenses:	'	'	'	'
Change in fair value of warrant liability	'	232	-210	-926
Common Stock [Member]	'	'	'	'
Operating expenses:	'	'	'	'
Change in fair value of warrant liability	'	'	-2,151	'
Convertible Notes [Member]	'	'	'	'
Operating expenses:	'	'	'	'
Change in fair value of derivative liabilities	'	'	$4,032	$1,800

Condensed_Consolidated_Stateme1

Condensed Consolidated Statements of Cash Flows (Unaudited) (USD $)	6 Months Ended
In Thousands, unless otherwise specified	Jun. 30, 2014	Jun. 30, 2013
CASH FLOWS FROM OPERATING ACTIVITIES	'	'
Net loss	($34,728)	($33,486)
Adjustments to reconcile net loss to net cash used in operating activities:	'	'
Depreciation	1,019	910
Amortization of discount on debt and capital leases	1,122	2,907
Amortization of debt issuance cost	99	78
Extinguishment of warrant liability upon exercise of put option by warrant holder	1,356	'
Loss on extinguishment of 2013 Notes	8,331	'
Stock-based compensation expense	2,327	123
Interest on convertible notes converted to convertible preferred stock	'	9,220
Interest for new debt upon issuance, non-cash	271	'
Capitalized interest	-411	0
Changes in operating assets and liabilities:	'	'
Prepaid expenses and other current assets	-1,340	388
Other non-current assets	-1,055	-2,032
Accounts payable	-4,084	5,187
Accruals and other current liabilities	1,716	-3,089
Deferred rent	451	68
Deferred revenue	-83	'
Net cash used in operating activities	-33,260	-27,306
CASH FLOWS FROM INVESTING ACTIVITIES	'	'
Purchases of property and equipment	-3,418	-2,318
Change in restricted cash	75	75
Net cash used in investing activities	-3,343	-2,243
CASH FLOWS FROM FINANCING ACTIVITIES	'	'
Proceeds from issuance of convertible notes and notes payable	6,750	'
Principal payments made on capital leases and financing obligation	-66	-613
Principal payments made on notes payable	-4,106	-3,705
Proceeds from the exercise of stock options and employee stock purchase plan	303	4
Payments to settle warrants	-1,438	'
Net cash provided by financing activities	235,997	36,392
NET INCREASE IN CASH AND CASH EQUIVALENTS	199,394	6,843
CASH AND CASH EQUIVALENTS - Beginning of period	3,914	4,083
CASH AND CASH EQUIVALENTS - End of period	203,308	10,926
SUPPLEMENTAL DISCLOSURES OF CASH FLOW INFORMATION:	'	'
Cash paid for interest	696	881
SUPPLEMENTAL DISCLOSURES OF NON-CASH INVESTING AND FINANCING INFORMATION:	'	'
Conversion of Series E-1, E-2, E-3, E-4 and E-5 preferred stock into common stock	123,982	'
Conversion of 2013 Notes into common stock	26,206	'
Issuance of common stock upon net exercise of common stock warrants in connection with IPO	6,490	'
Fair value in excess of debt host for derivative liabilities associated with convertible notes	1,050	'
Deferred initial public offering costs	4,028	'
Deferred follow-on public offering costs	546	'
Conversion of preferred stock warrants to common stock warrants	1,441	'
Termination of stock option repurchase right	58	'
Capital contribution on the extinguishment of the prior convertible preferred stock	'	74,894
Capital contribution on the extinguishment of the 2011 Notes	'	32,008
Deemed dividend on issuance of Series E-5 convertible preferred stock	'	177
Issuance of common stock warrants in connection with the 2013 Notes	981	'
Accrual for reimbursable tenant improvements	1,109	'
Property and equipment purchases included in accounts payable and accruals and other current liabilities	1,484	1,183
Rescission of note receivable from stockholder	'	60
Issuance of convertible preferred stock warrants	80	'
Essex Notes [Member]	'	'
CASH FLOWS FROM FINANCING ACTIVITIES	'	'
Principal payments made on notes payable	-200	'
SUPPLEMENTAL DISCLOSURES OF NON-CASH INVESTING AND FINANCING INFORMATION:	'	'
Capital contribution on the extinguishment of the 2011 Notes	1,095	'
Follow-on public offering [Member]	'	'
CASH FLOWS FROM FINANCING ACTIVITIES	'	'
Proceeds from issuance of common stock, net of deferred offering costs	131,882	'
Initial public offering [Member]	'	'
CASH FLOWS FROM FINANCING ACTIVITIES	'	'
Proceeds from issuance of common stock, net of deferred offering costs	102,672	'
Convertible preferred stock [Member]	'	'
Adjustments to reconcile net loss to net cash used in operating activities:	'	'
Revaluation of stock warrant liability	210	926
CASH FLOWS FROM FINANCING ACTIVITIES	'	'
Proceeds from issuance of convertible preferred stock, net	'	40,703
Series E-5 convertible preferred stock [Member]	'	'
SUPPLEMENTAL DISCLOSURES OF NON-CASH INVESTING AND FINANCING INFORMATION:	'	'
Issuance of common stock warrants in connection with Series E-5 convertible preferred stock financing	'	4,272
Common Stock [Member]	'	'
Adjustments to reconcile net loss to net cash used in operating activities:	'	'
Revaluation of stock warrant liability	2,151	'
CASH FLOWS FROM FINANCING ACTIVITIES	'	'
Proceeds from the exercise of common stock warrants	'	3
Medicis settlement [Member]	'	'
Adjustments to reconcile net loss to net cash used in operating activities:	'	'
Revaluation of derivative liabilities	493	221
Changes in operating assets and liabilities:	'	'
Payments against Medicis liabilities	-7,073	-6,927
Convertible Notes [Member]	'	'
Adjustments to reconcile net loss to net cash used in operating activities:	'	'
Amortization of debt issuance cost	1,250	9,204
Revaluation of derivative liabilities	($4,032)	($1,800)

The_Company_and_Basis_of_Prese

The Company and Basis of Presentation	6 Months Ended
	Jun. 30, 2014
Accounting Policies [Abstract]	'
The Company and Basis of Presentation	'
	1	The Company and Basis of Presentation
	Revance Therapeutics, Inc., or the Company, was incorporated in Delaware on August 10, 1999 under the name Essentia Biosystems, Inc. The Company commenced operations in June 2002 and on April 19, 2005, changed its name to Revance Therapeutics, Inc. The Company is a clinical stage specialty biopharmaceutical company focused on the development, manufacturing and commercialization of novel botulinum toxin products for multiple aesthetic and therapeutic applications. Botulinum toxin is a well-characterized protein currently used in numerous aesthetic and therapeutic indications representing a multi-billion dollar market in the United States and other countries. All currently approved and commercially available botulinum toxin products are administered by injection. The Company’s lead product candidate, RT001, is a topical formulation of botulinum toxin type A, which we believe has significant advantages over existing injectable products and could significantly grow the botulinum toxin market. The Company’s second product candidate, RT002, is a novel injectable formulation of botulinum toxin type A designed to be more targeted and longer lasting than currently available botulinum toxin injectable products. These product candidates combine the Company’s purified botulinum toxin with the Company’s proprietary TransMTS® peptide delivery system. The Company owns the worldwide rights to both of its product candidates.
	Since commencing operations in 2002, the Company has devoted substantially all of its efforts identifying and developing product candidates for the aesthetics and therapeutic pharmaceutical markets, recruiting personnel and raising capital. The Company has devoted predominantly all of its resources to preclinical, clinical, and manufacturing development of RT001 and RT002. The Company has never been profitable and has not yet commenced commercial operations.
	Since the Company’s inception, the Company has incurred losses and negative cash flows from operations. For the six months ended June 30, 2014, the Company had a net loss of $34.7 million, which includes net non-cash interest expenses of $9.4 million. The Company also used $33.3 million of cash for operating activities. As of June 30, 2014, the Company had a working capital surplus of $187.8 million and an accumulated deficit of $230.6 million. The Company believes that its existing cash and cash equivalents, including net proceeds from its initial public offering of $98.6 million, net proceeds from its follow-on public offering of $131.3 million, and existing Essex Capital credit facility will allow the Company to fund its operating plan through at least the next 12 months.
	Basis of Presentation
	The accompanying unaudited Condensed Consolidated Financial Statements, in the opinion of management, include all adjustments which the Company considers necessary for the fair statement of the condensed results of operations and cash flows for the interim periods covered and the condensed consolidated financial position of the Company at the date of the balance sheets. The December 31, 2013 Condensed Consolidated Balance Sheet was derived from audited financial statements, but does not include all disclosures required by generally accepted accounting principles in the United States of America, or US GAAP. The interim results presented herein are not necessarily indicative of the results of operations that may be expected for the full fiscal year ending December 31, 2014, or any other future period.
	The Condensed Consolidated Financial Statements should be read in conjunction with the Company’s audited consolidated financial statements contained in the Company’s Annual Report on Form 10-K for the year ended December 31, 2013, which was filed with the Securities and Exchange Commission, or SEC, on March 28, 2014.
	The Condensed Consolidated Financial Statements of the Company include the Company’s accounts and those of the Company’s wholly-owned subsidiary and have been prepared in conformity with accounting principles generally accepted in the United States of America, or US GAAP.
	Initial Public Offering
	In February 2014, the Company completed its initial public offering, or IPO, pursuant to which the Company issued 6,900,000 shares of common stock at $16.00 per share, including the exercise of the underwriters’ over-allotment option to purchase 900,000 additional shares of common stock, and received net proceeds of $98.6 million, after underwriting discounts, commissions and other offering expenses. In addition, in connection with the completion of the Company’s IPO, all convertible preferred stock converted into common stock.
	Follow-On Public Offering
	In June 2014, the Company completed a follow-on public offering, pursuant to which the Company issued 4,600,000 shares of common stock at $30.50 per share, including the exercise of the underwriters’ over-allotment option to purchase 600,000 additional shares of common stock, and received net proceeds of $131.3 million, after underwriting discounts, commissions and other offering expenses.

Summary_of_Significant_Account

Summary of Significant Accounting Policies	6 Months Ended
	Jun. 30, 2014
Accounting Policies [Abstract]	'
Summary of Significant Accounting Policies	'
	2	Summary of Significant Accounting Policies
	Significant accounting policies are described in Note 2 to the consolidated financial statements in Item 8 of the Company’s Annual Report on Form 10-K for the year ended December 31, 2013, which was filed with the SEC on March 28, 2014. There have been no changes to the Company’s significant accounting policies during the three or six months ended June 30, 2014, except as described in the Recent Accounting Pronouncements section below.
	Use of Estimates
	The preparation of Condensed Consolidated Financial Statements in conformity with US GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosures of contingent assets and liabilities at the date of the Condensed Consolidated Financial Statements and reported amounts of revenues and expenses during the reporting periods. Such management estimates include the fair value of common stock, stock-based compensation, fair value of convertible preferred stock and warrants, fair value of derivatives, and the valuation of deferred tax assets. The Company bases its estimates on historical experience and also on assumptions that it believes are reasonable, however, actual results could significantly differ from those estimates.
	Interest Expense
	Interest expense, includes cash and non-cash components with the non-cash components consisting of (i) interest recognized from the amortization of debt issuance costs that are generally derived from cash payments related to the issuance of convertible notes and notes payable, which were capitalized on the Condensed Consolidated Balance Sheets, (ii) interest recognized from the amortization of debt discounts derived from the issuance of warrants and derivatives issued in conjunction with convertible notes and notes payable, which were capitalized on the Condensed Consolidated Balance Sheets, (iii) interest recognized on 2011 convertible notes, or 2011 Notes, which was not paid but instead converted into shares of convertible preferred stock, (iv) interest recognized on the 2013 convertible notes, or 2013 Notes, which was not paid but instead converted into shares of common stock, (v) interest capitalized for assets constructed for use in operations, and (vi) interest related to the extinguishment of debt, which is classified as a gain or loss on debt extinguishments. The capitalized amounts related to the debt issuance costs and debt discounts are generally amortized to interest expense over the term of the related debt instruments.
	Recent Accounting Pronouncements
	In June 2014, the FASB issued Accounting Standard Update No. 2014-10, Development Stage Entities (Topic 915): Elimination of Certain Financial Reporting Requirements, Including an Amendment to Variable Interest Entities Guidance in Topic 810, Consolidation, which removes the distinction between development stage entities and other reporting entities, eliminates the exception provided to development stage entities for determining whether an entity is a variable interest entity on the basis of the amount of investment equity that is at risk, and clarifies disclosure requirements related to risks and uncertainties. The changes eliminate the requirements for development stage entities to (1) present inception-to-date information on the statements of operations, cash flows, and stockholders’ equity, (2) label the financial statements as those of a development stage entity, (3) disclose a description of the development stage activities in which the entity is engaged, and (4) disclose in the first year in which the entity is no longer a development stage entity that the prior years it had been in the development stage. The Company has evaluated the new guidance and determined that it will adopt the new standard early, beginning with this quarterly period ended June 30, 2014.

Medicis_Settlement

Medicis Settlement	6 Months Ended
	Jun. 30, 2014
Text Block [Abstract]	'
Medicis Settlement	'
	3	Medicis Settlement
	In October 2012, the Company entered into a settlement and termination agreement with Medicis Pharmaceutical Corporation, or Medicis. Medicis was subsequently acquired by Valeant Pharmaceuticals International, Inc. in December 2012. The terms of the settlement provided for the reacquisition of the rights related to all territories of RT001 and RT002 from Medicis and for consideration payable by the Company to Medicis of up to $25.0 million, comprised of (i) an upfront payment of $7.0 million, which was paid in November 2012, (ii) a Proceeds Sharing Arrangement Payment of $14.0 million due upon specified capital raising achievements by the Company, of which $6.9 million was paid in the second quarter of 2013 and the remaining $7.1 million was paid in the first quarter of 2014, and (iii) $4.0 million to be paid upon the achievement of specified regulatory milestones by the Company, or Product Approval Payment. The Company determined that the settlement provisions related to the Proceeds Sharing Arrangement Payment in (ii) above and the Product Approval Payment in (iii) above were derivative instruments that require fair value accounting as a liability and periodic fair value remeasurements until settled. Under the Proceeds Sharing Arrangement, the Company recorded $0.4 million to remeasure the fair value of the derivative for the remaining obligation through the date of settlement, or February 13, 2014. As of June 30, 2014, the Company determined the fair value of its liability for the Product Approval Payment was $1.7 million, which was measured by assuming a term of 2.75 years, a risk-free rate of 0.8% and a credit risk adjustment of 5.0%. The Company did not make any payments under the Product Approval Payment during the six months ended June 30, 2014.

Fair_Value_Measurements

Fair Value Measurements	6 Months Ended
	Jun. 30, 2014
Fair Value Disclosures [Abstract]	'
Fair Value Measurements	'
	4	Fair Value Measurements
	The Company measures and reports certain financial instruments as assets and liabilities at fair value on a recurring basis. These instruments consist of money market funds, derivative liabilities associated with convertible notes, derivative liabilities associated with the Medicis settlement, common stock warrant liabilities, and convertible preferred stock warrant liabilities. The fair value of these instruments was as follows (in thousands):
			As of June 30, 2014
			Fair Value			Level 1			Level 2			Level 3
	Assets
	Money market fund		$	190,000		$	190,000		$	—		$	—
	Total assets measured at fair value		$	190,000		$	190,000		$	—		$	—
			As of June 30, 2014
			Fair Value			Level 1			Level 2			Level 3
	Liabilities
	Derivative liabilities associated with the Medicis settlement		$	1,714		$	—		$	—		$	1,714
	Total liabilities measured at fair value		$	1,714		$	—		$	—		$	1,714
			As of December 31, 2013
			Fair Value			Level 1			Level 2			Level 3
	Liabilities
	Derivative liabilities associated with convertible notes		$	4,890		$	—		$	—		$	4,890
	Derivative liabilities associated with the Medicis settlement			8,294			—			—			8,294
	Common stock warrant liability			3,358			—			—			3,358
	Convertible preferred stock warrant liability			1,233			—			—			1,233
	Total liabilities measured at fair value		$	17,775		$	—		$	—		$	17,775
	The Company did not transfer any assets or liabilities measured at fair value on a recurring basis to or from Level 1 and Level 2 during the six months ended June 30, 2014 and the year ended December 31, 2013.
	The following table sets forth a summary of the changes in the fair value of the Company’s Level 3 financial instruments as follows (in thousands):
			Derivative			Derivative			Common			Convertible
			Liability			Liability			Stock Warrant			Preferred
			Associated with			Associated with			Liability			Stock Warrant
			Convertible			the Medicis						Liability
			Notes			Settlement
	Fair value as of December 31, 2013		$	4,890		$	8,294		$	3,358		$	1,233
	Fair value of financial instruments issued			1,050			—			981			80
	Cash payments against Medicis settlement			—			(7,073	)		—			—
	Change in fair value			(4,032	)		493			2,151			210
	Extinguishment of warrant liability upon exercise of put option by warrant holder			—			—			—			(82	)
	Conversion in connection with IPO			(1,908	)		—			(6,490	)		(1,441	)
	Fair value as of June 30, 2014		$	—		$	1,714		$	—		$	—
	Level 3 instruments consist of the Company’s derivative liabilities related to convertible notes, derivative liabilities related to the Medicis settlement, common stock warrant liabilities, and convertible preferred stock warrant liabilities. The fair value of the derivative liabilities associated with the convertible notes was measured using the Monte Carlo valuation methodology. Inputs used to determine estimated fair value of these derivative instruments include the probability estimates of potential settlement scenarios for the convertible notes, a present value discount rate and an estimate of the expected timing of settlement. The significant unobservable inputs used in the fair value measurement of the derivatives associated with the convertible notes are the scenario probabilities and the discount rate estimated at the valuation date. Generally, increases or decreases in the discount rate would result in a directionally opposite impact to the fair value measurement of this derivative instrument. Also, changes in the probability scenarios would have had varying impacts depending on the weighting of each specific scenario. Heavier weighting towards a change in control, a private investment in public equity transaction or IPO would result in an increase in fair value of this derivative instrument. The fair value upon the IPO took into account a 100% weighting towards the IPO scenario.
	The fair value of one of the derivative liabilities resulting from the Medicis litigation settlement, specifically the previously outstanding liability for the derivative related to the Proceeds Sharing Arrangement Payment (Note 3) as recognized cash payments against the liability, was measured using an option pricing model. Inputs used to determine estimated fair value of this derivative include the equity value of the Company, expected timing of the respective settlement payments, a risk-free interest rate and the expected volatility. The significant unobservable inputs used in the fair value measurement of the Proceeds Sharing Arrangement Payment derivative are the equity value of the Company and the expected timing of the payments at the valuation date. Generally, increases or decreases in these unobservable inputs would result in a directionally similar impact to the fair value measurement of this derivative instrument. The Company settled the remaining obligation under the Proceeds Sharing Arrangement upon the IPO. The Company remeasured the liability to the value of the remaining Proceeds Sharing Arrangement Payment, or $7.1 million.
	The fair value of the remaining derivative liability resulting from the Medicis litigation settlement, specifically the derivative related to the Product Approval Payment, was determined by estimating the timing and probability of the related regulatory approval and multiplying the payment amount by this probability percentage and a discount factor based primarily on the estimated timing of the payment and a credit risk adjustment. The significant unobservable inputs used in the fair value measurement of the Product Approval Payment derivative are the expected timing and probability of the payments at the valuation date and the credit risk adjustment.
	The fair values of the outstanding common stock warrants and previously outstanding convertible preferred stock warrants were measured using the Black-Scholes option-pricing model. Inputs used to determine estimated fair value of the warrant liabilities include the estimated fair value of the underlying stock at the valuation date, the estimated term of the warrants, risk-free interest rates, expected dividends and the expected volatility of the underlying stock. The significant unobservable inputs used in the fair value measurement of the convertible preferred stock warrant liability are the fair value of the underlying stock at the valuation date and the estimated term of the warrants.

Balance_Sheet_Components

Balance Sheet Components	6 Months Ended
	Jun. 30, 2014
Organization Consolidation And Presentation Of Financial Statements [Abstract]	'
Balance Sheet Components	'
	5	Balance Sheet Components
	Property and Equipment, net
	Property and equipment, net consists of the following (in thousands):
			As of			As of
			June 30,			December 31,
			2014			2013
	Research and manufacturing equipment		$	10,591		$	9,045
	Computer equipment			511			496
	Furniture and fixtures			518			451
	Leasehold improvements			3,632			3,632
	Construction in progress			10,279			8,880
	Total property and equipment			25,531			22,504
	Less: accumulated depreciation			(9,207	)		(8,189	)
	Property and equipment, net		$	16,324		$	14,315
	Depreciation expense was $0.5 million and $1.0 million and $0.4 million and $0.9 million for the three and six months ended June 30, 2014 and 2013, respectively.
	The Company has obligations to make future payments to certain vendors that become due and payable during the construction of its manufacturing facilities in Newark, California, in 2013. The arrangement was accounted for as construction-in-progress and the outstanding obligations as of June 30, 2014 and December 31, 2013 were $1.2 million and $1.8 million, respectively. The Company recorded capitalized interest costs of $0.2 million and $0.4 million during the three and six months ended June 30, 2014 and no capitalized interest during the three and six months ended June 30, 2013, respectively.
	Prepaid Expenses and Other Current Assets
	Prepaid expenses and other current assets consist of the following (in thousands):
			As of			As of
			June 30,			December 31,
			2014			2013
	Prepaid expenses		$	1,462		$	531
	Reimbursable tenant improvements			1,109			—
	Accounts receivable			188			225
	Deferred rent, current portion			282			—
	Other current assets			134			69
	Total prepaid expenses and other current assets		$	3,175		$	825
	Accruals and Other Current Liabilities
	Accruals and other current liabilities consist of the following (in thousands):
			As of			As of
			June 30,			December 31,
			2014			2013
	Accrued construction-in-progress obligations		$	240		$	1,757
	Accrued reimbursable tenant improvements			1,109			—
	Accrued compensation			1,316			689
	Accrued clinical trial expenses			388			169
	Accrued interest on notes payable			61			478
	Accrued offering costs			402			506
	Other current liabilities			1,517			562
	Total accruals and other current liabilities		$	5,033		$	4,161
	Other Non-Current Assets
	Other non-current assets consist of the following (in thousands):
			As of			As of
			June 30,			December 31,
			2014			2013
	Deferred initial public offering costs		$	—		$	2,812
	Unamortized debt issuance costs			—			194
	Total other non-current assets		$	—		$	3,006

Notes_Payable

Notes Payable	6 Months Ended
	Jun. 30, 2014
Debt Disclosure [Abstract]	'
Notes Payable	'
	6	Notes Payable
	Hercules Notes Payable
	In September 2011, the Company entered into a loan and security agreement with Hercules Technology Growth Capital for $22.0 million, referred to as the Hercules Notes Payable. From the proceeds of the Hercules Notes Payable, $7.0 million was used to fully repay the principal and accrued interest due under the Venture Debt. At the time of the Venture Debt repayment, the remaining unamortized debt discount of $0.6 million was written-off to interest expense.
	The Hercules Notes Payable, which matures in March 2015, is secured by all assets of the Company, and bears interest at the greater of (i) 9.85% per annum or (ii) 9.85% per annum plus the difference of the prime rate less 3.25% per annum and contains covenants that require, among other things, that the Company seek consent from Hercules prior to certain corporate changes and provide certain unaudited financial information within 30 days after the end of each month. Starting in July 2012, the loan is to be repaid in 33 equal monthly payments of principal and interest of $0.8 million plus an end of term payment of $0.5 million if the loan is prepaid, or $0.4 million if paid upon maturity. The loan also allows for prepayment at any time with a premium ranging from 1% to 4% of $15.0 million, depending on when the prepayment occurs.
	In connection with the Hercules Notes Payable, the Company issued warrants to purchase 17,977 shares of Series D convertible preferred stock at $66.75 per share, which converted to common stock upon the Company’s IPO. The fair value of the warrants of $0.1 million was recorded as a debt discount and is amortized to interest expense using the straight-line method over the loan term. The Company recognized interest expense of $0.01 million and $0.02 million, and $0.02 million and $0.05 million, from the amortization of the warrant related debt discount for the three and six months ended June 30, 2014 and 2013, respectively. The unamortized debt discount balance was $0.02 million and $0.04 million as of June 30, 2014 and December 31, 2013, respectively. The Company incurred $0.5 million of debt issuance costs in connection with the Hercules Notes Payable which is also being amortized to interest expense over the term of the borrowings. The Company recognized interest expense of $0.04 million and $0.08 million, and $0.04 million and $0.08 million, from the amortization of the debt issuance costs during the three and six months ended June 30, 2014 and 2013, respectively. The unamortized debt issuance costs balances were $0.1 million and $0.2 million as of June 30, 2014 and December 31, 2013, respectively.
	Essex Capital Notes
	On December 20, 2013, the Company signed a Loan and Lease Agreement to borrow up to $10.8 million in the form of Secured Promissory Notes from Essex Capital, or the Essex Notes, to finance the completion and installation of the Company’s RT001 commercial fill/finish line, or the Fill/Finish Line. Under the Loan and Lease Agreement, with the issuance of each Note, the Company will issue warrants to purchase its capital stock. Upon acceptance of the Fill/Finish Line by the Company, Essex Capital will purchase the Fill/Finish Line at the original invoice amounts in exchange for extinguishing the principal balance due under the Essex Notes. Concurrently with this sale, the Company will lease the Fill/Finish Line from Essex Capital for a fixed monthly payment to be paid monthly over three years. At the end of the lease, the Company will have the option to purchase the Fill/Finish Line for 10% of the original purchase amount. During the term of the Essex Notes, the Company will make interest only payments. The Essex Notes must be repaid in full if the Fill/Finish Line is not accepted and the sale-leaseback is not executed prior to the one year anniversary of the Essex Notes. In December 2013, the Company drew down $2.5 million under short-term notes pursuant to the Essex Capital Facility, and an additional $2.5 million in January 2014 under short-term notes. In May 2014, pursuant to the terms of this agreement, the Company sold equipment to Essex Capital, resulting in partial settlement of the outstanding loan balance by $1.1 million. Pursuant to the Loan and Lease Agreement, the Company leased the equipment from Essex Capital. This transaction does not qualify for sale-leaseback accounting due to the Company’s continuing involvement. Therefore, the Company accounted for this transaction as a financing obligation using the effective interest rate method. As of June 30, 2014, the aggregate total future minimum lease payments under the financing obligation were as follows (in thousands):
	Year Ending December 31,
	2014		$	211
	2015			423
	2016			423
	2017			141
	Total payments		$	1,198
	In connection with the Essex Notes, the Company is required to issue the warrants regardless of whether it draws down the full $10.8 million under the agreement, unless it chooses to discontinue construction of the equipment. The Company issued warrants to Essex to purchase 12,345 shares of Series E-5 convertible preferred stock in December 2013 and January 2014. Subsequent to the IPO in February 2014, the previously issued warrants to purchase shares of Series E-5 convertible preferred stock converted into warrants to purchase shares of common stock. The fair value of the warrants at the issuance date of $0.2 million and debt issuance costs totaling $0.03 million were recorded as discount on debt, and will be amortized to interest expense using the straight-line method over the loan term. The Company recognized interest expense of $0.1 million and $0.1 million for the amortization of the warrant related debt discount for the three and six months ended June 30, 2014, respectively. The unamortized debt discount balance was $0.1 million as of June 30, 2014.
	As of June 30, 2014, future principal payments under the Notes Payable are as follows (in thousands):
	2014		$	8,214
	2015			2,641
	Total principal payments			10,855
	Less: debt discount			(141	)
	Less: current portion			(10,714	)
	Long-term portion of notes payable		$	0
	During the three and six months ended June 30, 2014 and 2013, the Company made principal and interest payments on the Hercules Notes Payable of $2.3 million and $4.6 million and $2.3 million and $4.6 million, respectively. Additionally, the Company made interest payments on the Essex Notes in the amount of $0.1 million and $0.2 million during the three and six months ended June 30, 2014, respectively. As of June 30, 2014, the outstanding Hercules Notes Payable and Essex Notes balances were $7.0 million and $3.9 million, respectively.

2013_Convertible_Notes_and_Com

2013 Convertible Notes and Common Stock Warrants	6 Months Ended
	Jun. 30, 2014
Text Block [Abstract]	'
2013 Convertible Notes and Common Stock Warrants	'
	7	2013 Convertible Notes and Common Stock Warrants
	At December 31, 2013, the 2013 Notes had an aggregate outstanding principal amount of $19.4 million. In January 2014, the Company issued an additional $4.3 million in 2013 Notes. In February 2014, in connection with the Company’s IPO, the 2013 Notes with a principal amount, accrued interest, and derivative liability of $26.2 million converted into 1,637,846 shares of the Company’s common stock. In connection with the issuance of the 2013 Notes, the Company issued warrants to purchase 409,450 shares of common stock. In February 2014, in connection with the Company’s IPO, these warrants were net exercised for 405,594 shares of common stock.
	Additionally, the 2013 Notes had conversion and redemption features which were determined to be embedded derivatives, requiring bifurcation and separate fair value accounting. Immediately prior to the conversion, the Company determined that the fair value of the derivative liabilities associated with the convertible notes was reduced to $1.9 million. Upon the conversion of the 2013 Notes into shares of common stock, the Company applied extinguishment accounting resulting in a loss of $8.3 million as discussed in Note 8 below. As of the date of conversion, the Company was in compliance with all covenants in the 2013 Notes.
	During the six months ended June 30, 2014, the Company recognized non-cash interest expense of $9.6 million related to the 2013 Notes, including amortization of warrant-related debt discount of approximately $0.4 million up to the date of conversion, amortization of the derivative-related debt discount of $0.6 million up to the date of conversion, accrued interest of $0.3 million up to the date of conversion and a loss on extinguishment of $8.3 million upon conversion of the 2013 Notes into common stock. The Company had unamortized debt discount balance $0 and $7.3 million as of June 30, 2014 and December 31, 2013, respectively.

Interest_Expense

Interest Expense	6 Months Ended
	Jun. 30, 2014
Banking And Thrift Interest [Abstract]	'
Interest Expense	'
	8	Interest Expense
	Interest expense, includes cash and non-cash components with the non-cash components consisting of (i) interest recognized from the amortization of debt issuance costs that are generally derived from cash payments related to the issuance of convertible notes and notes payable, which were capitalized on the Condensed Consolidated Balance Sheets, (ii) interest recognized from the amortization of debt discounts derived from the issuance of warrants and derivatives issued in conjunction with convertible notes and notes payable, which were capitalized on the Condensed Consolidated Balance Sheets, (iii) interest recognized on 2011 convertible notes, or 2011 Notes, which was not paid but instead converted into shares of convertible preferred stock, (iv) interest recognized on the 2013 convertible notes, or 2013 Notes, which was not paid but instead converted into shares of common stock, (v) interest capitalized for assets constructed for use in operations, and (vi) interest related to the extinguishment of debt, which is classified as a gain or loss on debt extinguishments. The capitalized amounts related to the debt issuance costs and debt discounts are generally amortized to interest expense over the term of the related debt instruments.
	The interest expense by cash and non-cash components is as follows (in thousands):
			Three Months Ended						Six Months Ended
			June 30,						June 30,
			2014			2013			2014			2013
	Cash interest expense (1)		$	(324	)	$	(417	)	$	(696	)	$	(881	)
	Non-cash interest expense
	Non-cash interest expense — debt issuance costs			(48	)		(39	)		(100	)		(140	)
	Non-cash interest expense — warrant and derivative related debt discounts			(75	)		(34	)		(142	)		(2,890	)
	Non-cash interest expense — convertible notes			—			—			(1,250	)		(9,204	)
	Loss on extinguishment of 2013 Notes			—			—			(8,331	)		—
	Non-cash capitalized interest expense (2)			180			—			411			—
	Total non-cash interest expense			57			(73	)		(9,412	)		(12,234	)
	Total interest expense			(267	)		(490	)	$	(10,108	)	$	(13,115	)
	(1)	Cash interest expense included interest payments under the Hercules Notes Payable and Essex Notes.
	(2)	Interest expense capitalized pursuant to Accounting Standards Codification Topic 835, Interest.

Commitments_and_Contingencies

Commitments and Contingencies	6 Months Ended
	Jun. 30, 2014
Commitments And Contingencies Disclosure [Abstract]	'
Commitments and Contingencies	'
	9	Commitments and Contingencies
	Facility Lease
	In January 2010, the Company entered into a non-cancelable facility lease that requires monthly payments through January 2022. This facility will be used for research, manufacturing, and administrative functions.
	In February 2014, the Company extended the term of the Lease by thirty-six (36) months to January 2025. As part of this agreement, the Lessor shall provide the Company with a tenant improvement allowance during 2014 in an amount not to exceed $3.0 million. Under the terms of the lease, the Company’s payments escalate over the term of the lease; however, the Company recognizes the expense on a straight-line basis over the life of the lease.
	Rent expense was $1.3 million and $2.6 million and $1.1 million and $2.2 million for the three and six months ended June 30, 2014 and 2013.
	As of June 30, 2014, the aggregate total future minimum lease payments under non-cancelable operating leases were as follows (in thousands):
	Year Ending December 31,
	2014		$	2,456
	2015			5,070
	2016			5,222
	2017			5,394
	2018 and thereafter			37,932
	Total payments		$	56,074
	Other Milestone-Based Commitments
	The Company has one remaining obligation to make a future milestone payment to List Laboratories that becomes due and payable on the achievement of a certain regulatory milestone. The Company is obligated to pay royalties to List Laboratories on future sales of botulinum toxin products.
	Purchase Commitments
	The Company has certain commitments from outstanding purchase orders primarily related to the acquisition of equipment to be installed in the Company’s manufacturing facility and the cost of the design, construction, and installation of the Company’s fill to finish line. These agreements, which total $15.4 million, are cancellable at any time with the Company required to pay all costs incurred through the cancellation date.
	Contingencies
	From time to time, the Company may have certain contingent liabilities that arise in the ordinary course of business activities. The Company accrues a liability for such matters when it is probable that future expenditures will be made and such expenditures can be reasonably estimated. The Company is not subject to any known current pending legal matters or claims that would have a material adverse effect on its financial position, results of operations or cash flows.
	Indemnification
	The Company enters into standard indemnification agreements in the ordinary course of business. Pursuant to these arrangements, the Company indemnifies, holds harmless, and agrees to reimburse the indemnified parties for losses suffered or incurred by the indemnified party, in connection with any trade secret, copyright, patent or other intellectual property infringement claim by any third party with respect to its technology. The term of these indemnification agreements is generally perpetual after the execution of the agreement. The maximum potential amount of future payments the Company could be required to make under these agreements is not determinable because it involves claims that may be made against the Company in the future, but have not yet been made. The Company has not incurred costs to defend lawsuits or settle claims related to these indemnification agreements.
	The Company has entered into indemnification agreements with its directors and officers that may require the Company to indemnify its directors and officers against liabilities that may arise by reason of their status or service as directors or officers, other than liabilities arising from willful misconduct of the individual.
	No amounts associated with such indemnifications have been recorded to date.

Common_Stock

Common Stock	6 Months Ended
	Jun. 30, 2014
Text Block [Abstract]	'
Common Stock	'
	10	Common Stock
	Reverse Stock Split
	In January 2014, the Company’s Board of Directors and stockholders approved an amended and restated certificate of incorporation effecting a 1-for-15 reverse stock split of the Company’s issued and outstanding shares of common stock and convertible preferred stock that was effective on February 3, 2014. The par value of the common and convertible preferred stock was not adjusted as a result of the reverse stock split. All issued and outstanding share and per share amounts included in the accompanying financial statements have been retroactively adjusted to reflect this reverse stock split.

Convertible_Preferred_Stock

Convertible Preferred Stock	6 Months Ended
	Jun. 30, 2014
Equity [Abstract]	'
Convertible Preferred Stock	'
	11	Convertible Preferred Stock
	In connection with the IPO in February 2014, the Company converted the convertible preferred stock into 8,689,999 shares of common stock at a ratio of 1:1.

Warrants

Warrants	6 Months Ended
	Jun. 30, 2014
Text Block [Abstract]	'
Warrants	'
	12	Warrants
	In January 2014, the Company issued warrants to purchase 72,248 shares of common stock in connection with the issuance of the most recent round of the 2013 Notes (see Note 7 for additional information). In February 2014, following the completion of the Company’s IPO, all outstanding common stock warrants net exercised into 1,158,443 shares of common stock.
	In January 2014, in connection with the Company’s issuance of notes payable to Essex Capital (see Note 6 for additional information), the Company issued warrants to purchase 12,345 shares of Series E-5 convertible preferred stock. In February 2014, two holders of preferred stock warrants exercised their put options to sell 22,856 warrants at an exercise price equal to the average fair value of the Company’s stock price for 5 days preceding the exercise. The Company recorded a loss on cash settlement of $1.4 million as a result of this exercise.
	Upon completion of the IPO, all outstanding warrants to purchase Series E convertible preferred stock, excluding the 22,856 warrants that were exercised, converted into 173,975 warrants to purchase common stock at prices ranging from $14.95 per share to $31.50 per share, expiring in 2018 through 2021. In May 2014, warrants to purchase 20,066 shares of common stock were net exercised into 10,613 shares of common stock. As of June 30, 2014, the Company had warrants to purchase 153,909 shares of common stock outstanding and no convertible preferred stock warrants outstanding.

Equity_Incentive_Plans

Equity Incentive Plans	6 Months Ended
	Jun. 30, 2014
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract]	'
Equity Incentive Plans	'
	13	Equity Incentive Plans
	2014 Equity Incentive Plan
	On January 22, 2014, the Company’s board of directors authorized the adoption of the 2014 Equity Incentive Plan, or 2014 EIP, which became effective after adoption and approval by the Company’s stockholders on January 23, 2014. Initially, the aggregate number of shares of common stock that may be issued pursuant to stock awards under the 2014 EIP will not exceed 1,000,000 shares. The number of shares of common stock reserved for issuance under the Company’s 2014 EIP will automatically increase on January 1 of each year, beginning on January 1, 2015 and continuing through and including January 1, 2024, by 4% of the total number of shares of the Company’s capital stock outstanding on December 31 of the preceding calendar year or a lesser number of shares determined by the Company’s board of directors. The maximum number of shares that may be issued upon the exercise of ISOs under the Company’s 2014 EIP is 2,000,000 shares. The 2014 EIP provides for the grant of incentive stock options, or ISOs, nonstatutory stock options, or NSOs, stock appreciation rights, restricted stock awards, restricted stock unit awards, performance-based stock awards, and other forms of equity compensation, all of which may be granted to employees, including officers, non-employee directors and consultants of the Company and its affiliates. Additionally, the 2014 EIP provides for the grant of performance cash awards. ISOs may be granted only to employees. All other awards may be granted to employees, including officers, and to non-employee directors and consultants. During the second quarter of 2014, the Company granted stock options for 650,500 shares of common stock and 205,050 restricted stock awards under the 2014 EIP to non-employee directors and employees. As of June 30, 2014, there were 0.1 million shares available for issuance under the 2014 EIP.
	The fair value of the option component of the shares expected to be purchased under the 2014 EIP were estimated using the Black-Scholes option-pricing model with the following assumptions:
			Employee			Non-employee
			Three Months ended		Six Months ended	Three Months ended		Six Months ended
			30-Jun-14		30-Jun-14	30-Jun-14		30-Jun-14
	Expected term (in years)		5.50 – 6.08		5.50 – 6.08	8.90 – 9.67		5.00 – 9.67
	Expected volatility		56.19 – 57.95%		56.19 – 58.37%	57.14 – 58.46%		54.14 – 58.46%
	Risk-free interest rate		1.83 – 2.03%		1.69 – 2.03%	2.48 – 2.67%		1.67 – 2.67%
	Expected dividend rate		0.00%		0.00%	0.00%		0.00%
	Fair Value of Common Stock. The fair value of the shares of common stock is based on the Company’s stock price.
	Expected Term. The expected term for employees is based on the simplified method, as the Company’s stock options have the following characteristics: (i) granted at-the-money; (ii) exercisability is conditioned upon service through the vesting date; (iii) termination of service prior to vesting results in forfeiture; (iv) limited exercise period following termination of service; and (v) options are non-transferable and non-hedgeable, or “plain vanilla” options, and the Company has limited history of exercise data. The expected term for non-employees is based on the remaining contractual term.
	Expected Volatility. Since the Company was a private entity with little historical data regarding the volatility of its common stock, the expected volatility used is based on volatility of a group of similar entities. In evaluating similarity, the Company considered factors such as industry, stage of life cycle and size. The Company will continue to analyze the historical stock price volatility and expected term assumptions as more historical data for the Company’s common stock becomes available.
	Risk-Free Interest Rate. The risk-free interest rate is based on U.S. Treasury constant maturity treasury rates with remaining terms similar to the expected term.
	Expected Dividend Rate. The Company has never paid any dividends and does not plan to pay dividends in the foreseeable future, and, therefore, used an expected dividend rate of zero in the valuation model.
	2014 Employee Stock Purchase Plan
	On January 22, 2014, the Company’s board of directors authorized the adoption of the 2014 Employee Stock Purchase Plan, or 2014 ESPP, which became effective after adoption and approval by the Company’s stockholders on January 23, 2014. The maximum number of shares of common stock that may be issued under the Company’s 2014 ESPP is initially 200,000 shares. The number of shares of common stock reserved for issuance under the Company’s 2014 ESPP will automatically increase on January 1 of each year, beginning on January 1 of the year after the closing of our IPO and ending on and including January 1, 2024, by the lesser of (i) 1% of the total number of shares of common stock outstanding on December 31 of the preceding calendar year, (ii) 300,000 shares of common stock or (iii) such lesser number of shares of common stock as determined by the Company’s board of directors. Shares subject to purchase rights granted under the Company’s 2014 ESPP that terminate without having been exercised in full will return to the 2014 ESPP reserve and will not reduce the number of shares available for issuance under the Company’s 2014 ESPP. The 2014 ESPP is intended to qualify as an “employee stock purchase plan,” or ESPP, under Section 423 of the Internal Revenue Code of 1986 with the purpose of providing employees with an opportunity to purchase the Company’s common stock through accumulated payroll deductions. As of June 30, 2014, the Company recorded stock-based compensation expense of $0.5 million and issued 20,274 shares of common stock to employees under the 2014 ESPP.
	The fair value of the option component of the shares expected to be purchased under the 2014 ESPP were estimated using the Black-Scholes option-pricing model with the following assumptions:
			Three and
			Six Months ended
			30-Jun-14
	Expected term (in years)			0.5
	Expected volatility			48	%
	Risk-free interest rate			0.08	%
	Expected dividend rate			0	%
	Fair Value of Common Stock. The fair value of the shares of common stock is based on the Company’s stock price.
	Expected Term. The expected term is based on the term of the purchase period under the 2014 ESPP.
	Expected Volatility. Since the Company was a private entity with little historical data regarding the volatility of its common stock, the expected volatility used is based on volatility of a group of similar entities. In evaluating similarity, the Company considered factors such as industry, stage of life cycle and size. The Company will continue to analyze the historical stock price volatility and expected term assumptions as more historical data for the Company’s common stock becomes available.
	Risk-Free Interest Rate. The risk-free interest rate is based on U.S. Treasury constant maturity treasury rates with remaining terms similar to the expected term.
	Expected Dividend Rate. The Company has never paid any dividends and does not plan to pay dividends in the foreseeable future, and, therefore, used an expected dividend rate of zero in the valuation model.
	Stock-based Compensation to Employees
	Total stock-based compensation expense related to stock options, restricted stock awards, and ESPP granted to employees was allocated as follows (in thousands):
			Three Months						Six Months
			Ended						Ended
			June 30,						June 30,
			2014			2013			2014		2013
	Research and development		$	584		$	30		$	829	$	34
	Sales, general and administrative			866			65			1,106		70
	Total stock based compensation expense		$	1,450		$	95		$	1,935	$	104
	Stock-based compensation to Non-Employees
	Total stock-based compensation expense related to options granted to non-employees was allocated as follows (in thousands):
			Three Months						Six Months
			Ended						Ended
			June 30,						June 30,
			2014			2013			2014		2013
	Research and development		$	8		$	7		$	258	$	8
	Sales, general and administrative			41			6			134		11
	Total stock based compensation expense		$	49		$	13		$	392	$	19

Net_Income_Loss_per_Share_Attr

Net Income (Loss) per Share Attributable to Common Stockholders	6 Months Ended
	Jun. 30, 2014
Earnings Per Share [Abstract]	'
Net Income (Loss) per Share Attributable to Common Stockholders	'
	14	Net Income (Loss) per Share Attributable to Common Stockholders
	The following table sets forth the computation of the Company’s basic and diluted net income (loss) per share attributable to common stockholders for the three and six months ended June 30, 2014 and 2013 (in thousands, except for share and per share amounts):
			Three Months Ended						Six Months Ended
			June 30,						June 30,
			2014			2013			2014			2013
	Net loss		$	(13,302	)	$	(11,829	)	$	(34,728	)	$	(33,486	)
	Capital contribution on the extinguishment of prior convertible preferred stock			—			—			—			74,894
	Deemed dividend on the issuance of Series E-5 convertible preferred stock			—			—			—			(177	)
	Noncumulative dividend on Series E convertible preferred stock			—			(3,921	)		—			(6,064	)
	Undistributed earnings allocated to preferred stockholders			—			—			—			(33,810	)
	Net income (loss) attributable to common stockholders, basic		$	(13,302	)	$	(15,750	)	$	(34,728	)	$	1,357
	Adjustments to net income (loss) for dilutive securities			—			—			—			4,332
	Net income (loss) attributable to common stockholders, diluted		$	(13,302	)	$	(15,750	)	$	(34,728	)	$	5,689
	Net income (loss) per share attributable to common stockholders
	Basic		$	(0.69	)	$	(75.25	)	$	(2.26	)	$	6.56
	Diluted		$	(0.69	)	$	(75.25	)	$	(2.26	)	$	5.72
	Weighted-average shares used in computing net income (loss) per share attributable to common stockholders:
	Basic			19,380,934			209,307			15,361,215			206,751
	Diluted			19,380,934			209,307			15,361,215			994,239
	The following common stock equivalents were excluded from the computation of diluted net income (loss) per share for the periods presented because including them would have been antidilutive:
			As of June 30,
			2014			2013
	Stock options			1,890,019			771,573
	Convertible preferred stock			—			8,514,773
	Convertible preferred stock warrants			—			180,845
	Common stock warrants			153,909			—

Income_Taxes

Income Taxes	6 Months Ended
	Jun. 30, 2014
Income Tax Disclosure [Abstract]	'
Income Taxes	'
	15	Income Taxes
	Provision for Income Tax
	The Company’s effective tax rate is 0% for income tax for the three and six months ended June 30, 2014 and the Company expects that its effective tax rate for the full year 2014 will be 0%. Based on the weight of available evidence, including cumulative losses since inception and expected future losses, the Company has determined that it is more likely than not that the deferred tax asset amount will not be realized and therefore a valuation allowance has been provided on net deferred tax assets.
	In general, if the Company experiences a greater than 50 percentage point aggregate change in ownership over a three-year period (a Section 382 ownership change), utilization of its pre-change net operating loss, or NOL, and credit carryforwards are subject to an annual limitation under Sections 382 and 383 of the Internal Revenue Code. California and New Jersey, where the Company files state tax returns, have similar laws. The annual limitation generally is determined by multiplying the value of the Company’s stock at the time of such ownership change (subject to certain adjustments) by the applicable long-term tax-exempt rate. Such limitations may result in expiration of a portion of the NOL or tax credit carryforwards before utilization. The Company determined that ownership changes occurred in April 2004 and February 2014. As a result of the 2014 change, approximately $1.4 million of federal net operating loss carryforwards and $4.8 million of federal research and development, or R&D, credits are expected to expire unused. As of March 31, 2014, the Company derecognized $1.4 million of federal NOLs and $4.8 million of federal R&D credits. Since the R&D credits for California carry over indefinitely, there was no change to the California R&D credits. In order for the Company to trigger another Section 382 ownership change, the Company would need to experience a greater than 50 percentage point aggregate change in ownership within a three-year period beginning in February 2014. The Company determined that a Section 382 ownership change did not occur upon the June 2014 follow-on public offering.
	The Company files tax returns for U.S. Federal, State of California, and State of New Jersey. The Company is not currently subject to any income tax examinations. Since the Company’s inception, the Company had incurred losses from operations, which generally allows all tax years to remain open.
	Uncertain Tax Positions
	The Company recognizes the financial statement effects of a tax position when it becomes more likely than not, based upon the technical merits, that the position will be sustained upon examination. The Company does not expect any material changes in the next 12 months in unrecognized tax benefits.
	The Company recognizes interest and/or penalties related to uncertain tax positions. To the extent accrued interest and penalties do not ultimately become payable, amounts accrued will be reduced and reflected in the period that such determination is made. The interest and penalties are recognized as other expense and not tax expense. The Company currently has no interest and penalties related to uncertain tax positions.

The_Company_and_Basis_of_Prese1

The Company and Basis of Presentation (Policies)	6 Months Ended
	Jun. 30, 2014
Accounting Policies [Abstract]	'
Basis of Presentation	'
	Basis of Presentation
	The accompanying unaudited Condensed Consolidated Financial Statements, in the opinion of management, include all adjustments which the Company considers necessary for the fair statement of the condensed results of operations and cash flows for the interim periods covered and the condensed consolidated financial position of the Company at the date of the balance sheets. The December 31, 2013 Condensed Consolidated Balance Sheet was derived from audited financial statements, but does not include all disclosures required by generally accepted accounting principles in the United States of America, or US GAAP. The interim results presented herein are not necessarily indicative of the results of operations that may be expected for the full fiscal year ending December 31, 2014, or any other future period.
	The Condensed Consolidated Financial Statements should be read in conjunction with the Company’s audited consolidated financial statements contained in the Company’s Annual Report on Form 10-K for the year ended December 31, 2013, which was filed with the Securities and Exchange Commission, or SEC, on March 28, 2014.
	The Condensed Consolidated Financial Statements of the Company include the Company’s accounts and those of the Company’s wholly-owned subsidiary and have been prepared in conformity with accounting principles generally accepted in the United States of America, or US GAAP.
Initial Public Offering	'
	Initial Public Offering
	In February 2014, the Company completed its initial public offering, or IPO, pursuant to which the Company issued 6,900,000 shares of common stock at $16.00 per share, including the exercise of the underwriters’ over-allotment option to purchase 900,000 additional shares of common stock, and received net proceeds of $98.6 million, after underwriting discounts, commissions and other offering expenses. In addition, in connection with the completion of the Company’s IPO, all convertible preferred stock converted into common stock.
Follow-On Public Offering	'
	Follow-On Public Offering
	In June 2014, the Company completed a follow-on public offering, pursuant to which the Company issued 4,600,000 shares of common stock at $30.50 per share, including the exercise of the underwriters’ over-allotment option to purchase 600,000 additional shares of common stock, and received net proceeds of $131.3 million, after underwriting discounts, commissions and other offering expenses.
Use of Estimates	'
	Use of Estimates
	The preparation of Condensed Consolidated Financial Statements in conformity with US GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosures of contingent assets and liabilities at the date of the Condensed Consolidated Financial Statements and reported amounts of revenues and expenses during the reporting periods. Such management estimates include the fair value of common stock, stock-based compensation, fair value of convertible preferred stock and warrants, fair value of derivatives, and the valuation of deferred tax assets. The Company bases its estimates on historical experience and also on assumptions that it believes are reasonable, however, actual results could significantly differ from those estimates.
Interest Expense	'
	Interest Expense
	Interest expense, includes cash and non-cash components with the non-cash components consisting of (i) interest recognized from the amortization of debt issuance costs that are generally derived from cash payments related to the issuance of convertible notes and notes payable, which were capitalized on the Condensed Consolidated Balance Sheets, (ii) interest recognized from the amortization of debt discounts derived from the issuance of warrants and derivatives issued in conjunction with convertible notes and notes payable, which were capitalized on the Condensed Consolidated Balance Sheets, (iii) interest recognized on 2011 convertible notes, or 2011 Notes, which was not paid but instead converted into shares of convertible preferred stock, (iv) interest recognized on the 2013 convertible notes, or 2013 Notes, which was not paid but instead converted into shares of common stock, (v) interest capitalized for assets constructed for use in operations, and (vi) interest related to the extinguishment of debt, which is classified as a gain or loss on debt extinguishments. The capitalized amounts related to the debt issuance costs and debt discounts are generally amortized to interest expense over the term of the related debt instruments.
Recent Accounting Pronouncements	'
	Recent Accounting Pronouncements
	In June 2014, the FASB issued Accounting Standard Update No. 2014-10, Development Stage Entities (Topic 915): Elimination of Certain Financial Reporting Requirements, Including an Amendment to Variable Interest Entities Guidance in Topic 810, Consolidation, which removes the distinction between development stage entities and other reporting entities, eliminates the exception provided to development stage entities for determining whether an entity is a variable interest entity on the basis of the amount of investment equity that is at risk, and clarifies disclosure requirements related to risks and uncertainties. The changes eliminate the requirements for development stage entities to (1) present inception-to-date information on the statements of operations, cash flows, and stockholders’ equity, (2) label the financial statements as those of a development stage entity, (3) disclose a description of the development stage activities in which the entity is engaged, and (4) disclose in the first year in which the entity is no longer a development stage entity that the prior years it had been in the development stage. The Company has evaluated the new guidance and determined that it will adopt the new standard early, beginning with this quarterly period ended June 30, 2014.

Fair_Value_Measurements_Tables

Fair Value Measurements (Tables)	6 Months Ended
	Jun. 30, 2014
Fair Value Disclosures [Abstract]	'
Schedule of Fair Value of Financial Instruments	'
	The fair value of these instruments was as follows (in thousands):
		As of June 30, 2014
		Fair Value			Level 1			Level 2			Level 3
	Assets
	Money market fund	$	190,000		$	190,000		$	—		$	—
	Total assets measured at fair value	$	190,000		$	190,000		$	—		$	—
		As of June 30, 2014
		Fair Value			Level 1			Level 2			Level 3
	Liabilities
	Derivative liabilities associated with the Medicis settlement	$	1,714		$	—		$	—		$	1,714
	Total liabilities measured at fair value	$	1,714		$	—		$	—		$	1,714
		As of December 31, 2013
		Fair Value			Level 1			Level 2			Level 3
	Liabilities
	Derivative liabilities associated with convertible notes	$	4,890		$	—		$	—		$	4,890
	Derivative liabilities associated with the Medicis settlement		8,294			—			—			8,294
	Common stock warrant liability		3,358			—			—			3,358
	Convertible preferred stock warrant liability		1,233			—			—			1,233
	Total liabilities measured at fair value	$	17,775		$	—		$	—		$	17,775
Summary of Changes in Fair Value of Financial Instruments	'
	The following table sets forth a summary of the changes in the fair value of the Company’s Level 3 financial instruments as follows (in thousands):
		Derivative			Derivative			Common			Convertible
		Liability			Liability			Stock Warrant			Preferred
		Associated with			Associated with			Liability			Stock Warrant
		Convertible			the Medicis						Liability
		Notes			Settlement
	Fair value as of December 31, 2013	$	4,890		$	8,294		$	3,358		$	1,233
	Fair value of financial instruments issued		1,050			—			981			80
	Cash payments against Medicis settlement		—			(7,073	)		—			—
	Change in fair value		(4,032	)		493			2,151			210
	Extinguishment of warrant liability upon exercise of put option by warrant holder		—			—			—			(82	)
	Conversion in connection with IPO		(1,908	)		—			(6,490	)		(1,441	)
	Fair value as of June 30, 2014	$	—		$	1,714		$	—		$	—

Balance_Sheet_Components_Table

Balance Sheet Components (Tables)	6 Months Ended
	Jun. 30, 2014
Organization Consolidation And Presentation Of Financial Statements [Abstract]	'
Schedule of Property and Equipment, Net	'
	Property and equipment, net consists of the following (in thousands):
		As of			As of
		June 30,			December 31,
		2014			2013
	Research and manufacturing equipment	$	10,591		$	9,045
	Computer equipment		511			496
	Furniture and fixtures		518			451
	Leasehold improvements		3,632			3,632
	Construction in progress		10,279			8,880
	Total property and equipment		25,531			22,504
	Less: accumulated depreciation		(9,207	)		(8,189	)
	Property and equipment, net	$	16,324		$	14,315
Schedule of Prepaid Expenses and Other Current Assets	'
	Prepaid expenses and other current assets consist of the following (in thousands):
		As of			As of
		June 30,			December 31,
		2014			2013
	Prepaid expenses	$	1,462		$	531
	Reimbursable tenant improvements		1,109			—
	Accounts receivable		188			225
	Deferred rent, current portion		282			—
	Other current assets		134			69
	Total prepaid expenses and other current assets	$	3,175		$	825
Schedule of Accruals and Other Current Liabilities	'
	Accruals and other current liabilities consist of the following (in thousands):
		As of			As of
		June 30,			December 31,
		2014			2013
	Accrued construction-in-progress obligations	$	240		$	1,757
	Accrued reimbursable tenant improvements		1,109			—
	Accrued compensation		1,316			689
	Accrued clinical trial expenses		388			169
	Accrued interest on notes payable		61			478
	Accrued offering costs		402			506
	Other current liabilities		1,517			562
	Total accruals and other current liabilities	$	5,033		$	4,161
Schedule of Other Non-Current Assets	'
	Other non-current assets consist of the following (in thousands):
		As of			As of
		June 30,			December 31,
		2014			2013
	Deferred initial public offering costs	$	—		$	2,812
	Unamortized debt issuance costs		—			194
	Total other non-current assets	$	—		$	3,006

Notes_Payable_Tables

Notes Payable (Tables)	6 Months Ended
	Jun. 30, 2014
Debt Disclosure [Abstract]	'
Summary of Aggregate Total Future Minimum Lease Payments under the Financing Obligation	'
	As of June 30, 2014, the aggregate total future minimum lease payments under the financing obligation were as follows (in thousands):
	Year Ending December 31,
	2014	$	211
	2015		423
	2016		423
	2017		141
	Total payments	$	1,198
Summary of Future Principal Payments under the Notes Payable	'
	As of June 30, 2014, future principal payments under the Notes Payable are as follows (in thousands):
	2014	$	8,214
	2015		2,641
	Total principal payments		10,855
	Less: debt discount		(141	)
	Less: current portion		(10,714	)
	Long-term portion of notes payable	$	0

Interest_Expense_Tables

Interest Expense (Tables)	6 Months Ended
	Jun. 30, 2014
Banking And Thrift Interest [Abstract]	'
Summary of Interest Expense by Cash and Non-Cash Components	'
	The interest expense by cash and non-cash components is as follows (in thousands):
			Three Months Ended						Six Months Ended
			June 30,						June 30,
			2014			2013			2014			2013
	Cash interest expense (1)		$	(324	)	$	(417	)	$	(696	)	$	(881	)
	Non-cash interest expense
	Non-cash interest expense — debt issuance costs			(48	)		(39	)		(100	)		(140	)
	Non-cash interest expense — warrant and derivative related debt discounts			(75	)		(34	)		(142	)		(2,890	)
	Non-cash interest expense — convertible notes			—			—			(1,250	)		(9,204	)
	Loss on extinguishment of 2013 Notes			—			—			(8,331	)		—
	Non-cash capitalized interest expense (2)			180			—			411			—
	Total non-cash interest expense			57			(73	)		(9,412	)		(12,234	)
	Total interest expense			(267	)		(490	)	$	(10,108	)	$	(13,115	)
	(1)	Cash interest expense included interest payments under the Hercules Notes Payable and Essex Notes.
	(2)	Interest expense capitalized pursuant to Accounting Standards Codification Topic 835, Interest.

Commitments_and_Contingencies_

Commitments and Contingencies (Tables)	6 Months Ended
	Jun. 30, 2014
Commitments And Contingencies Disclosure [Abstract]	'
Schedule of Future Minimum Lease Payments under Non-Cancelable Operating Leases	'
	As of June 30, 2014, the aggregate total future minimum lease payments under non-cancelable operating leases were as follows (in thousands):
	Year Ending December 31,
	2014	$	2,456
	2015		5,070
	2016		5,222
	2017		5,394
	2018 and thereafter		37,932
	Total payments	$	56,074

Equity_Incentive_Plans_Tables

Equity Incentive Plans (Tables)	6 Months Ended
	Jun. 30, 2014
2014 Equity Incentive Plan [Member]	'
Fair Value of Option Component of Shares Expected to be Purchased	'
	The fair value of the option component of the shares expected to be purchased under the 2014 EIP were estimated using the Black-Scholes option-pricing model with the following assumptions:
		Employee			Non-employee
		Three Months ended		Six Months ended	Three Months ended		Six Months ended
		30-Jun-14		30-Jun-14	30-Jun-14		30-Jun-14
	Expected term (in years)	5.50 – 6.08		5.50 – 6.08	8.90 – 9.67		5.00 – 9.67
	Expected volatility	56.19 – 57.95%		56.19 – 58.37%	57.14 – 58.46%		54.14 – 58.46%
	Risk-free interest rate	1.83 – 2.03%		1.69 – 2.03%	2.48 – 2.67%		1.67 – 2.67%
	Expected dividend rate	0.00%		0.00%	0.00%		0.00%
2014 Employee Stock Purchase Plan [Member]	'
Fair Value of Option Component of Shares Expected to be Purchased	'
	The fair value of the option component of the shares expected to be purchased under the 2014 ESPP were estimated using the Black-Scholes option-pricing model with the following assumptions:
		Three and
		Six Months ended
		30-Jun-14
	Expected term (in years)		0.5
	Expected volatility		48	%
	Risk-free interest rate		0.08	%
	Expected dividend rate		0	%
Employee Stock Options [Member]	'
Schedule of Stock-based Compensation Expense	'
	Total stock-based compensation expense related to stock options, restricted stock awards, and ESPP granted to employees was allocated as follows (in thousands):
		Three Months						Six Months
		Ended						Ended
		June 30,						June 30,
		2014			2013			2014		2013
	Research and development	$	584		$	30		$	829	$	34
	Sales, general and administrative		866			65			1,106		70
	Total stock based compensation expense	$	1,450		$	95		$	1,935	$	104
Non-employee Stock Options [Member]	'
Schedule of Stock-based Compensation Expense	'
	Total stock-based compensation expense related to options granted to non-employees was allocated as follows (in thousands):
		Three Months						Six Months
		Ended						Ended
		June 30,						June 30,
		2014			2013			2014		2013
	Research and development	$	8		$	7		$	258	$	8
	Sales, general and administrative		41			6			134		11
	Total stock based compensation expense	$	49		$	13		$	392	$	19

Net_Income_Loss_per_Share_Attr1

Net Income (Loss) per Share Attributable to Common Stockholders (Tables)	6 Months Ended
	Jun. 30, 2014
Earnings Per Share [Abstract]	'
Schedule of Computation of Basic and Diluted Net Income(Loss) Per Share Attributable to Common Stockholders	'
	The following table sets forth the computation of the Company’s basic and diluted net income (loss) per share attributable to common stockholders for the three and six months ended June 30, 2014 and 2013 (in thousands, except for share and per share amounts):
		Three Months Ended						Six Months Ended
		June 30,						June 30,
		2014			2013			2014			2013
	Net loss	$	(13,302	)	$	(11,829	)	$	(34,728	)	$	(33,486	)
	Capital contribution on the extinguishment of prior convertible preferred stock		—			—			—			74,894
	Deemed dividend on the issuance of Series E-5 convertible preferred stock		—			—			—			(177	)
	Noncumulative dividend on Series E convertible preferred stock		—			(3,921	)		—			(6,064	)
	Undistributed earnings allocated to preferred stockholders		—			—			—			(33,810	)
	Net income (loss) attributable to common stockholders, basic	$	(13,302	)	$	(15,750	)	$	(34,728	)	$	1,357
	Adjustments to net income (loss) for dilutive securities		—			—			—			4,332
	Net income (loss) attributable to common stockholders, diluted	$	(13,302	)	$	(15,750	)	$	(34,728	)	$	5,689
	Net income (loss) per share attributable to common stockholders
	Basic	$	(0.69	)	$	(75.25	)	$	(2.26	)	$	6.56
	Diluted	$	(0.69	)	$	(75.25	)	$	(2.26	)	$	5.72
	Weighted-average shares used in computing net income (loss) per share attributable to common stockholders:
	Basic		19,380,934			209,307			15,361,215			206,751
	Diluted		19,380,934			209,307			15,361,215			994,239
Summary of Common Stock Equivalents Excluded from Computation of Diluted Net Income (Loss) Per Share	'
	The following common stock equivalents were excluded from the computation of diluted net income (loss) per share for the periods presented because including them would have been antidilutive:
		As of June 30,
		2014			2013
	Stock options		1,890,019			771,573
	Convertible preferred stock		—			8,514,773
	Convertible preferred stock warrants		—			180,845
	Common stock warrants		153,909			—

The_Company_and_Basis_of_Prese2

The Company and Basis of Presentation - Additional Information (Detail) (USD $)	3 Months Ended		6 Months Ended			1 Months Ended
	Jun. 30, 2014	Jun. 30, 2013	Jun. 30, 2014	Jun. 30, 2013	Dec. 31, 2013	Feb. 28, 2014	Jun. 30, 2014
						Initial public offering [Member]	Follow on offering [Member]
Organization And Description Of Business [Line Items]	'	'	'	'	'	'	'
Company's incorporation date	'	'	10-Aug-99	'	'	'	'
Commencement date of operations	'	'	30-Jun-02	'	'	'	'
Change of entity name date	'	'	19-Apr-05	'	'	'	'
Net income loss	($13,302,000)	($11,829,000)	($34,728,000)	($33,486,000)	'	'	'
Non-cash interest expenses	'	'	9,400,000	'	'	'	'
Net cash used in operating activities	'	'	-33,260,000	-27,306,000	'	'	'
Working capital surplus	187,800,000	'	187,800,000	'	'	'	'
Accumulated deficit	-230,608,000	'	-230,608,000	'	-195,880,000	'	'
Net proceeds from initial public offering	'	'	'	'	'	98,600,000	'
Credit facility agreement period	'	'	'12 months	'	'	'	'
Common stock issued pursuant to initial public offering	'	'	'	'	'	6,900,000	4,600,000
Common stock issued, price per share	'	'	'	'	'	$16	$30.50
Option to purchase additional shares	'	'	'	'	'	900,000	600,000
Net proceeds after underwriting discounts, commissions and other offering expenses	'	'	'	'	'	'	$131,300,000

Medicis_Settlement_Additional_

Medicis Settlement - Additional Information (Detail) (Medicis Pharmaceutical Corporation [Member], USD $)	1 Months Ended		6 Months Ended	3 Months Ended				6 Months Ended
In Millions, unless otherwise specified	Nov. 30, 2012	Oct. 31, 2012	Jun. 30, 2014	Mar. 31, 2014	Jun. 30, 2013	Oct. 31, 2012	Oct. 31, 2012	Jun. 30, 2014
				Proceeds Sharing Arrangement [Member]	Proceeds Sharing Arrangement [Member]	Proceeds Sharing Arrangement [Member]	Product Approval Payment [Member]	Product Approval Payment Derivative [Member]
Settlement and Termination [Line Items]	'	'	'	'	'	'	'	'
Settlement Date	'	'	31-Oct-12	'	'	'	'	'
Settlement consideration payable	'	$25	'	'	'	'	'	'
Upfront payment paid	7	'	'	'	'	'	'	'
Settlement consideration payable, description	'	'	'The terms of the settlement provided for the reacquisition of the rights related to all territories of RT001 and RT002 from Medicis and for consideration payable by the Company to Medicis of up to $25.0 million, comprised of (i) an upfront payment of $7.0 million, which was paid in November 2012, (ii) a Proceeds Sharing Arrangement Payment of $14.0 million due upon specified capital raising achievements by the Company, of which $6.9 million was paid in the second quarter of 2013 and the remaining $7.1 million was paid in the first quarter of 2014, and (iii) $4.0 million to be paid upon the achievement of specified regulatory milestones by the Company, or Product Approval Payment.	'	'	'	'	'
Settlement agreement, payable	'	'	'	'	'	14	4	'
Proceeds sharing agreement payment	'	'	'	7.1	6.9	'	'	'
Gain (loss) on derivative liability due to remeasurement	'	'	0.4	'	'	'	'	'
Fair value of derivative liability	'	'	'	'	'	'	'	$1.70
Fair value of the warrants, expected contractual term (in years)	'	'	'	'	'	'	'	'2 years 9 months
Fair value of the warrants, risk-free interest rate	'	'	'	'	'	'	'	0.80%
Fair value of credit risk, percentage	'	'	'	'	'	'	'	5.00%

Fair_Value_Measurements_Schedu

Fair Value Measurements - Schedule of Fair Value of Financial Instruments (Detail) (Recurring [Member], USD $)	Jun. 30, 2014	Dec. 31, 2013
In Thousands, unless otherwise specified
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]	'	'
Total assets measured at fair value	$190,000	'
Total liabilities measured at fair value	1,714	17,775
Level 1 [Member]	'	'
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]	'	'
Total assets measured at fair value	190,000	'
Total liabilities measured at fair value	0	0
Level 2 [Member]	'	'
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]	'	'
Total assets measured at fair value	0	'
Total liabilities measured at fair value	0	0
Level 3 [Member]	'	'
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]	'	'
Total assets measured at fair value	0	'
Total liabilities measured at fair value	1,714	17,775
Derivative liabilities associated with the Medicis settlement [Member]	'	'
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]	'	'
Total liabilities measured at fair value	1,714	8,294
Derivative liabilities associated with the Medicis settlement [Member] | Level 1 [Member]	'	'
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]	'	'
Total liabilities measured at fair value	0	0
Derivative liabilities associated with the Medicis settlement [Member] | Level 2 [Member]	'	'
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]	'	'
Total liabilities measured at fair value	0	0
Derivative liabilities associated with the Medicis settlement [Member] | Level 3 [Member]	'	'
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]	'	'
Total liabilities measured at fair value	1,714	8,294
Derivative liabilities associated with convertible notes [Member]	'	'
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]	'	'
Total liabilities measured at fair value	'	4,890
Derivative liabilities associated with convertible notes [Member] | Level 1 [Member]	'	'
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]	'	'
Total liabilities measured at fair value	'	0
Derivative liabilities associated with convertible notes [Member] | Level 2 [Member]	'	'
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]	'	'
Total liabilities measured at fair value	'	0
Derivative liabilities associated with convertible notes [Member] | Level 3 [Member]	'	'
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]	'	'
Total liabilities measured at fair value	'	4,890
Common stock warrant liability [Member]	'	'
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]	'	'
Total liabilities measured at fair value	'	3,358
Common stock warrant liability [Member] | Level 1 [Member]	'	'
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]	'	'
Total liabilities measured at fair value	'	0
Common stock warrant liability [Member] | Level 2 [Member]	'	'
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]	'	'
Total liabilities measured at fair value	'	0
Common stock warrant liability [Member] | Level 3 [Member]	'	'
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]	'	'
Total liabilities measured at fair value	'	3,358
Convertible preferred stock warrant liability [Member]	'	'
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]	'	'
Total liabilities measured at fair value	'	1,233
Convertible preferred stock warrant liability [Member] | Level 1 [Member]	'	'
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]	'	'
Total liabilities measured at fair value	'	0
Convertible preferred stock warrant liability [Member] | Level 2 [Member]	'	'
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]	'	'
Total liabilities measured at fair value	'	0
Convertible preferred stock warrant liability [Member] | Level 3 [Member]	'	'
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]	'	'
Total liabilities measured at fair value	'	1,233
Money market fund [Member]	'	'
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]	'	'
Total assets measured at fair value	190,000	'
Money market fund [Member] | Level 1 [Member]	'	'
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]	'	'
Total assets measured at fair value	190,000	'
Money market fund [Member] | Level 2 [Member]	'	'
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]	'	'
Total assets measured at fair value	0	'
Money market fund [Member] | Level 3 [Member]	'	'
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items]	'	'
Total assets measured at fair value	$0	'

Fair_Value_Measurements_Summar

Fair Value Measurements - Summary of Changes in Fair Value of Financial Instruments (Detail) (USD $)	6 Months Ended
In Thousands, unless otherwise specified	Jun. 30, 2014
Derivative liabilities associated with convertible notes [Member]	'
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]	'
Fair value as of December 31, 2013	$4,890
Fair value of financial instruments issued	1,050
Cash payments against Medicis settlement	'
Change in fair value	-4,032
Extinguishment of warrant liability upon exercise of put option by warrant holder	'
Conversion in connection with IPO	-1,908
Fair value as of June 30, 2014	'
Derivative liabilities associated with the Medicis settlement [Member]	'
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]	'
Fair value as of December 31, 2013	8,294
Fair value of financial instruments issued	'
Cash payments against Medicis settlement	-7,073
Change in fair value	493
Extinguishment of warrant liability upon exercise of put option by warrant holder	'
Conversion in connection with IPO	'
Fair value as of June 30, 2014	1,714
Common stock warrant liability [Member]	'
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]	'
Fair value as of December 31, 2013	3,358
Fair value of financial instruments issued	981
Cash payments against Medicis settlement	'
Change in fair value	2,151
Extinguishment of warrant liability upon exercise of put option by warrant holder	'
Conversion in connection with IPO	-6,490
Fair value as of June 30, 2014	'
Convertible preferred stock warrant liability [Member]	'
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]	'
Fair value as of December 31, 2013	1,233
Fair value of financial instruments issued	80
Cash payments against Medicis settlement	'
Change in fair value	210
Extinguishment of warrant liability upon exercise of put option by warrant holder	-82
Conversion in connection with IPO	-1,441
Fair value as of June 30, 2014	'

Fair_Value_Measurements_Additi

Fair Value Measurements - Additional Information (Detail) (USD $)	6 Months Ended
In Millions, unless otherwise specified	Jun. 30, 2014
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]	'
Percentage of weighting took into account towards the IPO scenario	100.00%
Proceeds Sharing Arrangement [Member]	'
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]	'
Proceeds sharing agreement payment due upon IPO	7.1

Balance_Sheet_Components_Sched

Balance Sheet Components - Schedule of Property and Equipment, Net (Detail) (USD $)	Jun. 30, 2014	Dec. 31, 2013
In Thousands, unless otherwise specified
Property, Plant and Equipment [Line Items]	'	'
Property and equipment, gross	$25,531	$22,504
Less: accumulated depreciation	-9,207	-8,189
Property and equipment, net	16,324	14,315
Research and manufacturing equipment [Member]	'	'
Property, Plant and Equipment [Line Items]	'	'
Property and equipment, gross	10,591	9,045
Computer equipment [Member]	'	'
Property, Plant and Equipment [Line Items]	'	'
Property and equipment, gross	511	496
Furniture and fixtures [Member]	'	'
Property, Plant and Equipment [Line Items]	'	'
Property and equipment, gross	518	451
Leasehold improvements [Member]	'	'
Property, Plant and Equipment [Line Items]	'	'
Property and equipment, gross	3,632	3,632
Construction in progress [Member]	'	'
Property, Plant and Equipment [Line Items]	'	'
Property and equipment, gross	$10,279	$8,880

Balance_Sheet_Components_Addit

Balance Sheet Components - Additional Information (Detail) (USD $)	3 Months Ended		6 Months Ended		12 Months Ended
	Jun. 30, 2014	Jun. 30, 2013	Jun. 30, 2014	Jun. 30, 2013	Dec. 31, 2013
Collaboration Arrangement Disclosure [Abstract]	'	'	'	'	'
Depreciation expense	$500,000	$400,000	$1,019,000	$910,000	'
Outstanding obligations related to construction-in-progress	'	'	1,200,000	'	1,800,000
Capitalized interest costs	$180,000	$0	$411,000	$0	'

Balance_Sheet_Components_Sched1

Balance Sheet Components - Schedule of Prepaid Expenses and Other Current Assets (Detail) (USD $)	Jun. 30, 2014	Dec. 31, 2013
In Thousands, unless otherwise specified
Deferred Costs Capitalized Prepaid And Other Assets Disclosure [Abstract]	'	'
Prepaid expenses	$1,462	$531
Reimbursable tenant improvements	1,109	'
Accounts receivable	188	225
Deferred rent, current portion	282	'
Other current assets	134	69
Total prepaid expenses and other current assets	$3,175	$825

Balance_Sheet_Components_Sched2

Balance Sheet Components - Schedule of Accruals and Other Current Liabilities (Detail) (USD $)	6 Months Ended
In Thousands, unless otherwise specified	Jun. 30, 2014	Dec. 31, 2013
Payables And Accruals [Abstract]	'	'
Accrued construction-in-progress obligations	$240	$1,757
Accrued reimbursable tenant improvements	1,109	'
Accrued compensation	1,316	689
Accrued clinical trial expenses	388	169
Accrued interest on notes payable	61	478
Accrued offering costs	402	506
Other current liabilities	1,517	562
Total accruals and other current liabilities	$5,033	$4,161

Balance_Sheet_Components_Sched3

Balance Sheet Components - Schedule of Other Non-Current Assets (Detail) (USD $)	Jun. 30, 2014	Dec. 31, 2013
In Thousands, unless otherwise specified
Deferred Costs Capitalized Prepaid And Other Assets Disclosure [Abstract]	'	'
Deferred initial public offering costs	'	$2,812
Unamortized debt issuance costs	'	194
Total other non-current assets	'	$3,006

Notes_Payable_Additional_Infor

Notes Payable - Additional Information 1 (Detail) (USD $)	1 Months Ended	3 Months Ended		6 Months Ended
	Sep. 30, 2011	Jun. 30, 2014	Jun. 30, 2013	Jun. 30, 2014	Jun. 30, 2013	Dec. 31, 2013
Debt Instrument [Line Items]	'	'	'	'	'	'
Proceeds from notes payable	'	'	'	$6,750,000	'	'
Unamortized debt discount	'	141,000	'	141,000	'	'
Unamortized debt issuance costs	'	'	'	'	'	194,000
Hercules Notes Payable [Member]	'	'	'	'	'	'
Debt Instrument [Line Items]	'	'	'	'	'	'
Proceeds from notes payable	22,000,000	'	'	'	'	'
Unamortized debt discount	'	20,000	'	20,000	'	40,000
Notes payable maturity	'	'	'	31-Mar-15	'	'
Interest rate, percentage	'	9.85%	'	9.85%	'	'
Difference of the prime rate	'	'	'	3.25%	'	'
Notes payable repayment terms	'	'	'	'33 equal monthly payments	'	'
Notes payable description	'	'	'	'The Hercules Notes Payable, which matures in March 2015, is secured by all assets of the Company, and bears interest at the greater of (i) 9.85% per annum or (ii) 9.85% per annum plus the difference of the prime rate less 3.25% per annum and contains covenants that require, among other things, that the Company seek consent from Hercules prior to certain corporate changes and provide certain unaudited financial information within 30 days after the end of each month. Starting in July 2012, the loan is to be repaid in 33 equal monthly payments of principal and interest of $0.8 million plus an end of term payment of $0.5 million if the loan is prepaid, or $0.4 million if paid upon maturity. The loan also allows for prepayment at any time with a premium ranging from 1% to 4% of $15.0 million, depending on when the prepayment occurs.	'	'
Notes payable repayment start date	'	'	'	31-Jul-12	'	'
Payment of notes payable principal and interest	'	'	'	800,000	'	'
Prepayment charge on end of term payment	'	'	'	500,000	'	'
End of term payment	'	400,000	'	400,000	'	'
Prepayment premium amount	'	'	'	15,000,000	'	'
Warrants issued to purchase shares	'	'	'	17,977	'	'
Exercise price per share	'	'	'	$66.75	'	'
Debt discount amortized	'	'	'	100,000	'	'
Recognition of interest expense from warrant related debt discount	'	10,000	20,000	20,000	50,000	'
Debt issuance costs	'	'	'	500,000	'	'
Amortization of debt issuance costs	'	40,000	40,000	80,000	80,000	'
Unamortized debt issuance costs	'	100,000	'	100,000	'	200,000
Hercules Notes Payable [Member] | Minimum [Member]	'	'	'	'	'	'
Debt Instrument [Line Items]	'	'	'	'	'	'
Prepayment premium percentage	'	1.00%	'	1.00%	'	'
Hercules Notes Payable [Member] | Maximum [Member]	'	'	'	'	'	'
Debt Instrument [Line Items]	'	'	'	'	'	'
Prepayment premium percentage	'	4.00%	'	4.00%	'	'
Venture Debt [Member]	'	'	'	'	'	'
Debt Instrument [Line Items]	'	'	'	'	'	'
Repayment of Venture Debt	7,000,000	'	'	'	'	'
Unamortized debt discount	$600,000	'	'	'	'	'

Notes_Payable_Additional_Infor1

Notes Payable - Additional Information 2 (Detail) (USD $)

3 Months Ended

6 Months Ended

0 Months Ended

1 Months Ended

3 Months Ended

6 Months Ended

1 Months Ended

3 Months Ended

6 Months Ended

3 Months Ended

6 Months Ended

Jun. 30, 2014

Jun. 30, 2013

Jun. 30, 2014

Jun. 30, 2013

Dec. 20, 2013

31-May-14

Jun. 30, 2014

Jun. 30, 2014

Jan. 31, 2014

Dec. 31, 2013

Dec. 20, 2013

Dec. 20, 2013

Dec. 31, 2013

Jan. 31, 2014

Jun. 30, 2014

Jun. 30, 2014

Jun. 30, 2014

Jun. 30, 2013

Jun. 30, 2014

Jun. 30, 2013

Dec. 31, 2013

Essex Notes [Member]

Essex Notes [Member]

Essex Notes [Member]

Essex Notes [Member]

Essex Notes [Member]

Essex Notes [Member]

Essex Notes [Member]

Essex Notes [Member]

Essex Notes [Member]

Essex Notes [Member]

Essex Notes [Member]

Essex Notes [Member]

Hercules Notes Payable [Member]

Hercules Notes Payable [Member]

Hercules Notes Payable [Member]

Hercules Notes Payable [Member]

Hercules Notes Payable [Member]

Maximum [Member]

Short Term [Member]

Series E-5 convertible preferred stock [Member]

Warrants [Member]

Warrants [Member]

Debt Instrument [Line Items]

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

Secured promissory notes

'

'

'

'

'

'

'

'

'

'

'

$10,800,000

'

'

'

'

'

'

'

'

'

Lease period

'

'

'

'

'3 years

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

Percentage of original purchase amount of asset at end of lease

'

'

'

'

'

'

'

'

'

'

10.00%

'

'

'

'

'

'

'

'

'

'

Short-term notes

'

'

'

'

'

'

'

'

2,500,000

2,500,000

'

'

'

'

'

'

'

'

'

'

'

Reduction in outstanding loan balance

'

'

'

'

'

1,100,000

'

'

'

'

'

'

'

'

'

'

'

'

'

'

'

Common stock shares purchased

'

'

'

'

'

'

'

'

'

'

'

'

12,345

12,345

'

'

'

'

'

'

'

Fair value of warrants

'

'

'

'

'

'

200,000

200,000

'

'

'

'

'

'

'

'

'

'

'

'

'

Debt issuance costs

'

'

'

'

'

'

'

30,000

'

'

'

'

'

'

'

'

'

'

500,000

'

'

Interest expense for amortization of warrant

267,000

490,000

10,108,000

13,115,000

'

'

'

'

'

'

'

'

'

'

100,000

100,000

'

'

'

'

'

Unamortized debt discount

141,000

'

141,000

'

'

'

100,000

100,000

'

'

'

'

'

'

'

'

20,000

'

20,000

'

40,000

Payment of principal and interest, Notes payable

'

'

4,106,000

3,705,000

'

'

100,000

200,000

'

'

'

'

'

'

'

'

2,300,000

2,300,000

4,600,000

4,600,000

'

Notes payable outstanding

'

'

'

'

'

'

$3,900,000

$3,900,000

'

'

'

'

'

'

'

'

$7,000,000

'

$7,000,000

'

'

Notes_Payable_Summary_of_Aggre

Notes Payable - Summary of Aggregate Total Future Minimum Lease Payments under the Financing Obligation (Detail) (USD $)	Jun. 30, 2014
In Thousands, unless otherwise specified
Minimum Lease Payments Sale Leaseback Transactions [Abstract]	'
2014	$211
2015	423
2016	423
2017	141
Total payments	$1,198

Notes_Payable_Summary_of_Futur

Notes Payable - Summary of Future Principal Payments under the Notes Payable (Detail) (USD $)	Jun. 30, 2014	Dec. 31, 2013
In Thousands, unless otherwise specified
Less: debt discount	($141)	'
Less: current portion	-10,714	-10,702
Long-term portion of notes payable	0	2,632
Notes Payable [Member]	'	'
2014	8,214	'
2015	2,641	'
Total principal payments	$10,855	'

2013_Convertible_Notes_and_Com1

2013 Convertible Notes and Common Stock Warrants - Additional Information (Detail) (USD $)	1 Months Ended	6 Months Ended
	Feb. 28, 2014	Jun. 30, 2014	Jan. 31, 2014	Dec. 31, 2013
Debt Instrument [Line Items]	'	'	'	'
Derivative liabilities associated with the convertible notes	'	'	'	$4,890,000
Loss on extinguishment of 2013 Notes	'	-8,331,000	'	'
Unamortized debt discount	'	'	'	194,000
2013 Convertible Notes [Member]	'	'	'	'
Debt Instrument [Line Items]	'	'	'	'
Amount borrowed during the period	'	'	4,300,000	19,400,000
Principal amount, accrued interest, and derivative liability	26,200,000	'	'	'
Convertible notes converted into shares	1,637,846	'	'	'
Warrants issued to purchase of common stock	409,450	'	'	'
Warrants exercised for common stock	405,594	'	'	'
Derivative liabilities associated with the convertible notes	'	1,900,000	'	'
Loss on extinguishment of 2013 Notes	'	8,300,000	'	'
Non-cash interest expense	'	9,600,000	'	'
Amortization of warrant-related debt discount	'	400,000	'	'
Amortization of derivative-related debt discount	'	600,000	'	'
Accrued interest up to the date of conversion	'	300,000	'	'
Unamortized debt discount	'	$0	'	$7,300,000

Interest_Expense_Summary_of_In

Interest Expense - Summary of Interest Expense by Cash and Non-Cash Components (Detail) (USD $)	3 Months Ended		6 Months Ended
In Thousands, unless otherwise specified	Jun. 30, 2014	Jun. 30, 2013	Jun. 30, 2014	Jun. 30, 2013
Debt Instrument [Line Items]	'	'	'	'
Cash interest expense	($324)	($417)	($696)	($881)
Non-cash interest expense	'	'	'	'
Non-cash interest expense	'	'	-99	-78
Loss on extinguishment of 2013 Notes	'	'	-8,331	'
Non-cash capitalized interest expense	180	0	411	0
Total non-cash interest expense	57	-73	-9,412	-12,234
Total interest expense	-267	-490	-10,108	-13,115
Convertible Notes [Member]	'	'	'	'
Non-cash interest expense	'	'	'	'
Non-cash interest expense	0	0	-1,250	-9,204
Debt issuance costs [Member]	'	'	'	'
Non-cash interest expense	'	'	'	'
Non-cash interest expense	-48	-39	-100	-140
Warrant and Derivative Related Debt Discounts [Member]	'	'	'	'
Non-cash interest expense	'	'	'	'
Non-cash interest expense	-75	-34	-142	-2,890
2013 Notes [Member]	'	'	'	'
Non-cash interest expense	'	'	'	'
Loss on extinguishment of 2013 Notes	$0	$0	($8,331)	$0

Commitments_and_Contingencies_1

Commitments and Contingencies - Additional Information (Detail) (USD $)	1 Months Ended	3 Months Ended		6 Months Ended
	Feb. 28, 2014	Jun. 30, 2014	Jun. 30, 2013	Jun. 30, 2014	Jun. 30, 2013
Other Commitments [Line Items]	'	'	'	'	'
Extended term of lease	'36 months	'	'	'	'
Lease expiration date	'	'	'	31-Jan-25	'
Rent expense	'	$1,300,000	$1,100,000	$2,600,000	$2,200,000
Purchase commitments	'	15,400,000	'	15,400,000	'
Maximum [Member]	'	'	'	'	'
Other Commitments [Line Items]	'	'	'	'	'
Tenant improvement allowance	'	'	'	$3,000,000	'

Commitments_and_Contingencies_2

Commitments and Contingencies - Schedule of Future Minimum Lease Payments under Non-Cancelable Operating Leases (Detail) (USD $)	Jun. 30, 2014
In Thousands, unless otherwise specified
Leases [Abstract]	'
2014	$2,456
2015	5,070
2016	5,222
2017	5,394
2018 and thereafter	37,932
Total payments	$56,074

Common_Stock_Additional_Inform

Common Stock - Additional Information (Detail) (Common Stock [Member])	6 Months Ended
	Jun. 30, 2014
Common Stock [Member]	'
Class of Stock [Line Items]	'
Reverse stock split description	'Company's Board of Directors and stockholders approved an amended and restated certificate of incorporation effecting a 1-for-15 reverse stock split of the Company's issued and outstanding shares of common stock and convertible preferred stock that was effective on February 3, 2014.

Convertible_Preferred_Stock_Ad

Convertible Preferred Stock - Additional Information (Detail)	0 Months Ended
	Feb. 28, 2014
Equity [Abstract]	'
Conversion of convertible preferred stock into common stock shares	8,689,999
Conversion ratio	1

Warrants_Additional_Informatio

Warrants - Additional Information (Detail) (USD $)	6 Months Ended	1 Months Ended			1 Months Ended				6 Months Ended
In Thousands, except Share data, unless otherwise specified	Jun. 30, 2014	Feb. 28, 2014	Jun. 30, 2014	Jan. 31, 2014	31-May-14	Feb. 28, 2014	Jun. 30, 2014	Jan. 31, 2014	Jun. 30, 2014	Jun. 30, 2014
		Convertible Preferred Stock Warrants [Member]	Convertible Preferred Stock Warrants [Member]	Convertible Preferred Stock Warrants [Member]	Common stock warrants [Member]	Common stock warrants [Member]	Common stock warrants [Member]	Common stock warrants [Member]	Common stock warrants [Member]	Common stock warrants [Member]
		Warrant							Minimum [Member]	Maximum [Member]
Class of Warrant or Right [Line Items]	'	'	'	'	'	'	'	'	'	'
Warrants to purchase shares	'	'	0	12,345	20,066	'	153,909	72,248	'	'
Number of outstanding common stock warrants net exercised	'	'	'	'	10,613	1,158,443	'	'	'	'
Number of warrants to purchase shares exercised	'	22,856	'	'	'	'	'	'	'	'
Loss on extinguishment of warrant liability upon exercise of put option by warrant holder	($1,356)	$1,400	'	'	'	'	'	'	'	'
Number of preferred stock warrant holders	'	2	'	'	'	'	'	'	'	'
Warrant issued, purchase price per share	'	'	'	'	'	'	'	'	14.95	31.5
Warrant expiration year	'	'	'	'	'	'	'	'	'2018	'2021

Equity_Incentive_Plans_Additio

Equity Incentive Plans - Additional Information (Detail) (USD $)	6 Months Ended		3 Months Ended	6 Months Ended		6 Months Ended
In Thousands, except Share data, unless otherwise specified	Jun. 30, 2014	Jun. 30, 2013	Jun. 30, 2014	Jun. 30, 2014	Jun. 30, 2014	Jun. 30, 2014
			2014 Equity Incentive Plan [Member]	2014 Equity Incentive Plan [Member]	2014 Equity Incentive Plan [Member]	2014 Employee Stock Purchase Plan [Member]
					Maximum [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]	'	'	'	'	'	'
Number of common stock that may be issued pursuant to equity incentive plan	'	'	1,000,000	1,000,000	2,000,000	200,000
Percentage of total number of shares of capital stock outstanding	'	'	'	4.00%	'	1.00%
Stock options granted	'	'	650,500	'	'	'
Restricted stock awards, shares	'	'	205,050	'	'	'
Shares available for issuance	'	'	100,000	100,000	'	'
Additional shares reserved for issuance	'	'	'	'	'	300,000
Stock-based compensation	$2,327	$123	'	'	'	$500
Issued shares of common stock	'	'	'	'	'	20,274

Equity_Incentive_Plans_Fair_Va

Equity Incentive Plans - Fair Value of Option Component of Shares Expected to be Purchased (Detail)	3 Months Ended	6 Months Ended
	Jun. 30, 2014	Jun. 30, 2014
2014 Employee Stock Purchase Plan [Member]	'	'
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]	'	'
Expected term (in years)	'6 months	'6 months
Expected volatility	48.00%	48.00%
Risk-free interest rate	0.08%	0.08%
Expected dividend rate	0.00%	0.00%
2014 Equity Incentive Plan [Member] | Non-employee Stock Options [Member]	'	'
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]	'	'
Expected dividend rate	0.00%	0.00%
2014 Equity Incentive Plan [Member] | Non-employee Stock Options [Member] | Minimum [Member]	'	'
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]	'	'
Expected term (in years)	'8 years 10 months 24 days	'5 years
Expected volatility	57.14%	54.14%
Risk-free interest rate	2.48%	1.67%
2014 Equity Incentive Plan [Member] | Non-employee Stock Options [Member] | Maximum [Member]	'	'
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]	'	'
Expected term (in years)	'9 years 8 months 1 day	'9 years 8 months 1 day
Expected volatility	58.46%	58.46%
Risk-free interest rate	2.67%	2.67%
2014 Equity Incentive Plan [Member] | Employee Stock Options [Member]	'	'
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]	'	'
Expected dividend rate	0.00%	0.00%
2014 Equity Incentive Plan [Member] | Employee Stock Options [Member] | Minimum [Member]	'	'
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]	'	'
Expected term (in years)	'5 years 6 months	'5 years 6 months
Expected volatility	56.19%	56.19%
Risk-free interest rate	1.83%	1.69%
2014 Equity Incentive Plan [Member] | Employee Stock Options [Member] | Maximum [Member]	'	'
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]	'	'
Expected term (in years)	'6 years 29 days	'6 years 29 days
Expected volatility	57.95%	58.37%
Risk-free interest rate	2.03%	2.03%

Equity_Incentive_Plans_Schedul

Equity Incentive Plans - Schedule of Stock-based Compensation Expense (Detail) (USD $)	3 Months Ended		6 Months Ended
In Thousands, unless otherwise specified	Jun. 30, 2014	Jun. 30, 2013	Jun. 30, 2014	Jun. 30, 2013
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]	'	'	'	'
Total stock based compensation expense	'	'	$2,327	$123
Employee Stock Options [Member]	'	'	'	'
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]	'	'	'	'
Total stock based compensation expense	1,450	95	1,935	104
Employee Stock Options [Member] | Research and development [Member]	'	'	'	'
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]	'	'	'	'
Total stock based compensation expense	584	30	829	34
Employee Stock Options [Member] | Sales, general and administrative [Member]	'	'	'	'
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]	'	'	'	'
Total stock based compensation expense	866	65	1,106	70
Non-employee Stock Options [Member]	'	'	'	'
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]	'	'	'	'
Total stock based compensation expense	49	13	392	19
Non-employee Stock Options [Member] | Research and development [Member]	'	'	'	'
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]	'	'	'	'
Total stock based compensation expense	8	7	258	8
Non-employee Stock Options [Member] | Sales, general and administrative [Member]	'	'	'	'
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items]	'	'	'	'
Total stock based compensation expense	$41	$6	$134	$11

Net_Income_Loss_per_Share_Attr2

Net Income (Loss) per Share Attributable to Common Stockholders - Schedule of Computation of Basic and Diluted Net Income(Loss) Per Share Attributable to Common Stockholders (Detail) (USD $)	3 Months Ended		6 Months Ended
In Thousands, except Share data, unless otherwise specified	Jun. 30, 2014	Jun. 30, 2013	Jun. 30, 2014	Jun. 30, 2013
Earnings Per Share, Diluted, by Common Class, Including Two Class Method [Line Items]	'	'	'	'
Net loss	($13,302)	($11,829)	($34,728)	($33,486)
Capital contribution on the extinguishment of prior convertible preferred stock	'	'	'	74,894
Deemed dividend on the issuance of Series E-5 convertible preferred stock	'	'	'	-177
Undistributed earnings allocated to preferred stockholders	'	'	'	-33,810
Net income (loss) attributable to common stockholders, basic	-13,302	-15,750	-34,728	1,357
Adjustments to net income (loss) for dilutive securities	'	'	'	4,332
Net income (loss) attributable to common stockholders, diluted	-13,302	-15,750	-34,728	5,689
Net income (loss) per share attributable to common stockholders	'	'	'	'
Basic	($0.69)	($75.25)	($2.26)	$6.56
Diluted	($0.69)	($75.25)	($2.26)	$5.72
Weighted-average shares used in computing net income (loss) per share attributable to common stockholders:	'	'	'	'
Basic	19,380,934	209,307	15,361,215	206,751
Diluted	19,380,934	209,307	15,361,215	994,239
Series E convertible preferred stock [Member]	'	'	'	'
Earnings Per Share, Diluted, by Common Class, Including Two Class Method [Line Items]	'	'	'	'
Noncumulative dividend on Series E convertible preferred stock	'	($3,921)	'	($6,064)

Net_Income_Loss_per_Share_Attr3

Net Income (Loss) per Share Attributable to Common Stockholders - Summary of Common Stock Equivalents Excluded from Computation of Diluted Net Income (Loss) Per Share (Detail)	3 Months Ended
	Jun. 30, 2014	Jun. 30, 2013
Stock options [Member]	'	'
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]	'	'
Common stock equivalents excluded from computation of diluted net income (loss) per share	1,890,019	771,573
Convertible preferred stock [Member]	'	'
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]	'	'
Common stock equivalents excluded from computation of diluted net income (loss) per share	'	8,514,773
Convertible Preferred Stock Warrants [Member]	'	'
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]	'	'
Common stock equivalents excluded from computation of diluted net income (loss) per share	'	180,845
Common stock warrants [Member]	'	'
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]	'	'
Common stock equivalents excluded from computation of diluted net income (loss) per share	153,909	'

Income_Taxes_Additional_Inform

Income Taxes - Additional Information (Detail) (USD $)	3 Months Ended	6 Months Ended					6 Months Ended
In Millions, unless otherwise specified	Jun. 30, 2014	Jun. 30, 2014	Jun. 30, 2014	Mar. 31, 2014	Jun. 30, 2014	Mar. 31, 2014	Jun. 30, 2014
			Federal [Member]	Federal [Member]	Research and development tax credits [Member]	Research and development tax credits [Member]	Scenario, Forecast [Member]
					Federal [Member]	Federal [Member]
Income Tax Contingency [Line Items]	'	'	'	'	'	'	'
Effective tax rate	0.00%	'	'	'	'	'	0.00%
Operating loss carryforwards, limitations on use	'	'If the Company experiences a greater than 50 percentage point aggregate change in ownership over a three-year period (a Section 382 ownership change), utilization of its pre-change net operating loss, or NOL, and credit carryforwards are subject to an annual limitation under Sections 382 and 383 of the Internal Revenue Code. California and New Jersey, where the Company files state tax returns, have similar laws. The annual limitation generally is determined by multiplying the value of the Companybs stock at the time of such ownership change (subject to certain adjustments) by the applicable long-term tax-exempt rate.	'	'	'	'	'
Net operating loss carryforwards, amount	'	'	$1.40	'	'	'	'
Tax credit carryforwards, amount	'	'	'	'	4.8	'	'
Derecognition of net operating loss carryforwards	'	'	'	1.4	'	'	'
Derecognition of tax credit carryforwards	'	'	'	'	'	4.8	'
Interest and penalties related to uncertain tax positions	'	$0	'	'	'	'	'