Exhibit 23.1
Consent of Independent Registered Public Accounting Firm
We consent to the reference to our firm under the caption “Experts” and to the use of our report dated June 5, 2014, in the Registration Statement on Form S-1 and related Prospectus of Otonomy, Inc. dated July 11, 2014 for the registration of shares of its common stock.
/s/ Ernst & Young LLP
San Diego, California
July 11, 2014