CERTIFICATION UNDER SECTION 906 OF THE
SARBANES-OXLEY ACT OF 2002
I, Michele Janis and Anthony J Krick, Chief Financial Officer and Chief Accounting Officer of OptiNose, Inc. (the “Company”), do hereby certify, pursuant to 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that to the best of my knowledge
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| 1. | the Quarterly Report on Form 10-Q of the Company for the period ended September 30, 2022 (the “Report”) fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934, as amended; and |
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| 2. | the information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company for the periods presented therein. |
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| Date: | November 10, 2022 | | /s/ Michele Janis Michele Janis Chief Financial Officer (Principal Financial Officer) | | | | |
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| Date: | November 10, 2022 | | /s/ Anthony J. Krick Anthony J. Krick Chief Accounting Officer (Principal Accounting Officer) |
