The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||||||
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
ABBVIE INC | COM | 00287Y109 | 72,123 | 734,598 | SH | DFND | 1,2 | 734,598 | 0 | 0 | |
ADMA BIOLOGICS INC | COM | 000899104 | 5,816 | 1,984,949 | SH | DFND | 1,2 | 1,984,949 | 0 | 0 | |
AKEBIA THERAPEUTICS INC | COM | 00972D105 | 2,105 | 155,000 | SH | DFND | 1,2 | 155,000 | 0 | 0 | |
AKOUOS INC | COM | 00973J101 | 2,250 | 100,000 | SH | DFND | 1,2 | 100,000 | 0 | 0 | |
ALLOT LTD | SHS | M0854Q105 | 10,087 | 963,456 | SH | DFND | 963,456 | 0 | 0 | ||
AMAZON COM INC | COM | 023135106 | 11,918 | 4,320 | SH | DFND | 4,320 | 0 | 0 | ||
AMGEN INC | COM | 031162100 | 18,869 | 80,000 | SH | DFND | 1,2 | 80,000 | 0 | 0 | |
AMICUS THERAPEUTICS INC | COM | 03152W109 | 24,559 | 1,628,550 | SH | DFND | 1,2 | 1,628,550 | 0 | 0 | |
APREA THERAPEUTICS INC | COM | 03836J102 | 6,138 | 158,289 | SH | DFND | 1,2 | 158,289 | 0 | 0 | |
ARGENX SE | SPONSORED ADR | 04016X101 | 2,312 | 10,265 | SH | DFND | 1,2 | 10,265 | 0 | 0 | |
ARYA SCIENCES ACQUISITION CO | UNIT 10/04/2023 | G3165V117 | 4,000 | 200,000 | SH | DFND | 1,2 | 200,000 | 0 | 0 | |
ARYA SCIENCES ACQUISTION CO | UNIT 06/09/2027 | G31655114 | 3,480 | 300,000 | SH | DFND | 1,2 | 300,000 | 0 | 0 | |
ASCENDIS PHARMA A S | SPONSORED ADR | 04351P101 | 5,084 | 34,373 | SH | DFND | 1,2 | 34,373 | 0 | 0 | |
ASTRAZENECA PLC | SPONSORED ADR | 046353108 | 47,072 | 890,000 | SH | DFND | 1,2 | 890,000 | 0 | 0 | |
AXOVANT GENE THERAPIES | COM | G0750W203 | 8,060 | 2,857,998 | SH | DFND | 1,2 | 2,857,998 | 0 | 0 | |
BELLUS HEALTH INC NEW | COM NEW | 07987C204 | 1,006 | 97,805 | SH | DFND | 1,2 | 97,805 | 0 | 0 | |
BRISTOL-MYERS SQUIBB CO | COM | 110122108 | 41,160 | 700,000 | SH | DFND | 1,2 | 700,000 | 0 | 0 | |
CAMTEK LTD | ORD | M20791105 | 468 | 37,184 | SH | DFND | 37,184 | 0 | 0 | ||
CATALYST PHARMACEUTICALS INC | COM | 14888U101 | 3,375 | 730,557 | SH | DFND | 1,2 | 730,557 | 0 | 0 | |
CELLECTAR BIOSCIENCES INC | COM PAR | 15117F500 | 112 | 87,500 | SH | DFND | 1,2 | 87,500 | 0 | 0 | |
COMPUGEN LTD | ORD | M25722105 | 3,004 | 200,000 | SH | DFND | 1,2 | 200,000 | 0 | 0 | |
CONCERT PHARMACEUTICALS INC | COM | 206022105 | 6,972 | 700,710 | SH | DFND | 1,2 | 700,710 | 0 | 0 | |
CORBUS PHARMACEUTICALS HLDGS | CALL | 21833P103 | 2,001 | 238,500 | SH | Call | DFND | 1,2 | 0 | 0 | 238,500 |
DECIPHERA PHARMACEUTICALS IN | COM | 24344T101 | 16,899 | 282,965 | SH | DFND | 1,2 | 282,965 | 0 | 0 | |
DOMINOS PIZZA INC | COM | 25754A201 | 5,365 | 14,521 | SH | DFND | 14,521 | 0 | 0 | ||
DOVER CORP | COM | 260003108 | 5,560 | 57,576 | SH | DFND | 57,576 | 0 | 0 | ||
ENPHASE ENERGY INC | COM | 29355A107 | 3,330 | 70,000 | SH | DFND | 70,000 | 0 | 0 | ||
EXICURE INC | COM | 30205M101 | 4,636 | 1,900,000 | SH | DFND | 1,2 | 1,900,000 | 0 | 0 | |
FATE THERAPEUTICS INC | COM | 31189P102 | 7,720 | 225,000 | SH | DFND | 1,2 | 225,000 | 0 | 0 | |
FISERV INC | COM | 337738108 | 9,298 | 95,246 | SH | DFND | 95,246 | 0 | 0 | ||
FIVERR INTL LTD | ORD SHS | M4R82T106 | 12,328 | 167,002 | SH | DFND | 167,002 | 0 | 0 | ||
GALERA THERAPEUTICS INC | COM | 36338D108 | 3,350 | 469,245 | SH | DFND | 1,2 | 469,245 | 0 | 0 | |
HOMOLOGY MEDICINES INC | COM | 438083107 | 10,009 | 658,919 | SH | DFND | 1,2 | 658,919 | 0 | 0 | |
IMMUNIC INC | COM | 4525EP101 | 1,212 | 100,000 | SH | DFND | 1,2 | 100,000 | 0 | 0 | |
IMMUNOVANT INC | COM | 45258J102 | 2,557 | 105,000 | SH | DFND | 1,2 | 105,000 | 0 | 0 | |
INTRA CELLULAR THERAPIES INC | CALL | 46116X101 | 5,871 | 228,700 | SH | Call | DFND | 1,2 | 0 | 0 | 228,700 |
INVESCO QQQ TR | PUT | 46090E103 | 38,997 | 157,500 | SH | Put | DFND | 157,500 | 0 | 0 | |
IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 | 9,553 | 348,000 | SH | DFND | 1,2 | 348,000 | 0 | 0 | |
IVERIC BIO INC | COM | 46583P102 | 1,020 | 200,000 | SH | DFND | 1,2 | 200,000 | 0 | 0 | |
JOHNSON & JOHNSON | COM | 478160104 | 42,189 | 300,000 | SH | DFND | 1,2 | 300,000 | 0 | 0 | |
KALVISTA PHARMACEUTICALS INC | COM | 483497103 | 2,906 | 240,140 | SH | DFND | 1,2 | 240,140 | 0 | 0 | |
KARYOPHARM THERAPEUTICS INC | COM | 48576U106 | 7,440 | 392,831 | SH | DFND | 1,2 | 392,831 | 0 | 0 | |
KORNIT DIGITAL LTD | SHS | M6372Q113 | 9,422 | 176,507 | SH | DFND | 176,507 | 0 | 0 | ||
KRYSTAL BIOTECH INC | COM | 501147102 | 5,988 | 144,573 | SH | DFND | 1,2 | 144,573 | 0 | 0 | |
KURA ONCOLOGY INC | COM | 50127T109 | 8,712 | 534,494 | SH | DFND | 1,2 | 534,494 | 0 | 0 | |
LARIMAR THERAPEUTICS INC | COM | 517125100 | 5,099 | 396,787 | SH | DFND | 1,2 | 396,787 | 0 | 0 | |
LEAP THERAPEUTICS INC | COM | 52187K101 | 1,839 | 880,000 | SH | DFND | 1,2 | 880,000 | 0 | 0 | |
LILLY ELI & CO | COM | 532457108 | 14,776 | 90,000 | SH | DFND | 1,2 | 90,000 | 0 | 0 | |
MEI PHARMA INC | COM NEW | 55279B202 | 1,693 | 410,000 | SH | DFND | 1,2 | 410,000 | 0 | 0 | |
MERCK & CO. INC | COM | 58933Y105 | 60,612 | 783,808 | SH | DFND | 1,2 | 783,808 | 0 | 0 | |
MICROSOFT CORP | COM | 594918104 | 16,680 | 81,964 | SH | DFND | 81,964 | 0 | 0 | ||
MIRATI THERAPEUTICS INC | COM | 60468T105 | 8,220 | 72,000 | SH | DFND | 1,2 | 72,000 | 0 | 0 | |
MYOKARDIA INC | COM | 62857M105 | 9,662 | 100,000 | SH | DFND | 1,2 | 100,000 | 0 | 0 | |
NEOS THERAPEUTICS INC | COM | 64052L106 | 651 | 950,311 | SH | DFND | 1,2 | 950,311 | 0 | 0 | |
NEUBASE THERAPEUTICS INC | COM | 64132K102 | 1,317 | 150,000 | SH | DFND | 1,2 | 150,000 | 0 | 0 | |
NICE LTD | SPONSORED ADR | 653656108 | 24,489 | 129,406 | SH | DFND | 129,406 | 0 | 0 | ||
NICE SYS INC | NOTE 1.250% 1/1 | 65366HAB9 | 573 | 250,000 | SH | DFND | 250,000 | 0 | 0 | ||
NOVARTIS AG | SPONSORED ADR | 66987V109 | 15,721 | 180,000 | SH | DFND | 1,2 | 180,000 | 0 | 0 | |
NOVO-NORDISK A S | ADR | 670100205 | 26,192 | 400,000 | SH | DFND | 1,2 | 400,000 | 0 | 0 | |
ORGENESIS INC | COM NEW | 68619K204 | 4,048 | 665,767 | SH | DFND | 1,2 | 665,767 | 0 | 0 | |
OUTLOOK THERAPEUTICS INC | *W EXP 02/18/202 | 69012T115 | 33 | 129,500 | SH | DFND | 1,2 | 0 | 0 | 129,500 | |
PALO ALTO NETWORKS INC | COM | 697435105 | 6,890 | 30,000 | SH | DFND | 30,000 | 0 | 0 | ||
PASSAGE BIO INC | COM | 702712100 | 9,414 | 344,439 | SH | DFND | 1,2 | 344,439 | 0 | 0 | |
PERRIGO CO PLC | SHS | G97822103 | 2,764 | 50,000 | SH | DFND | 50,000 | 0 | 0 | ||
PFIZER INC | PUT | 717081103 | 32,700 | 1,000,000 | SH | Put | DFND | 1,2 | 1,000,000 | 0 | 0 |
REATA PHARMACEUTICALS INC | CL A | 75615P103 | 12,801 | 82,049 | SH | DFND | 1,2 | 82,049 | 0 | 0 | |
REPARE THERAPEUTICS INC | COM | 760273102 | 7,600 | 245,000 | SH | DFND | 1,2 | 245,000 | 0 | 0 | |
RETROPHIN INC | COM | 761299106 | 5,103 | 250,000 | SH | DFND | 1,2 | 250,000 | 0 | 0 | |
ROCKET PHARMACEUTICALS INC | COM | 77313F106 | 7,117 | 340,016 | SH | DFND | 1,2 | 340,016 | 0 | 0 | |
SANOFI | SPONSORED ADR | 80105N105 | 57,176 | 1,120,000 | SH | DFND | 1,2 | 1,120,000 | 0 | 0 | |
SAREPTA THERAPEUTICS INC | COM | 803607100 | 19,754 | 123,200 | SH | DFND | 1,2 | 123,200 | 0 | 0 | |
SOLAREDGE TECHNOLOGIES INC | COM | 83417M104 | 6,386 | 46,017 | SH | DFND | 46,017 | 0 | 0 | ||
SOLENO THERAPEUTICS INC | COM NEW | 834203200 | 2,739 | 1,233,676 | SH | DFND | 1,2 | 1,233,676 | 0 | 0 | |
SPDR S&P 500 ETF TR | PUT | 78462F103 | 58,280 | 189,000 | SH | Put | DFND | 189,000 | 0 | 0 | |
SPDR SER TR | PUT | 78464A870 | 83,962 | 750,000 | SH | Put | DFND | 1,2 | 750,000 | 0 | 0 |
SYNDAX PHARMACEUTICALS INC | COM | 87164F105 | 3,260 | 220,000 | SH | DFND | 1,2 | 220,000 | 0 | 0 | |
SYNDAX PHARMACEUTICALS INC | CALL | 87164F105 | 1,482 | 100,000 | SH | Call | DFND | 1,2 | 0 | 0 | 100,000 |
TCR2 THERAPEUTICS INC | COM | 87808K106 | 461 | 30,000 | SH | DFND | 1,2 | 30,000 | 0 | 0 | |
TEVA PHARMACEUTICAL INDS LTD | SPONSORED ADS | 881624209 | 7,187 | 582,878 | SH | DFND | 582,878 | 0 | 0 | ||
TRILLIUM THERAPEUTICS INC | COM NEW | 89620X506 | 9,533 | 1,178,346 | SH | DFND | 1,2 | 1,178,346 | 0 | 0 | |
UNIQURE NV | SHS | N90064101 | 4,957 | 110,000 | SH | DFND | 1,2 | 110,000 | 0 | 0 | |
VIKING THERAPEUTICS INC | COM | 92686J106 | 1,478 | 205,000 | SH | DFND | 1,2 | 205,000 | 0 | 0 | |
WAVE LIFE SCIENCES LTD | SHS | Y95308105 | 3,050 | 293,000 | SH | DFND | 1,2 | 293,000 | 0 | 0 | |
WIX COM LTD | SHS | M98068105 | 9,631 | 37,588 | SH | DFND | 37,588 | 0 | 0 | ||
X4 PHARMACEUTICALS INC | COM | 98420X103 | 5,273 | 565,804 | SH | DFND | 1,2 | 565,804 | 0 | 0 | |
Y-MABS THERAPEUTICS INC | COM | 984241109 | 12,193 | 282,252 | SH | DFND | 1,2 | 282,252 | 0 | 0 | |
ZYMEWORKS INC | COM | 98985W102 | 4,195 | 116,310 | SH | DFND | 1,2 | 116,310 | 0 | 0 |