The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||||||
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
ABBVIE INC | COM | 00287Y109 | 62,852 | 464,194 | SH | DFND | 1,2,3 | 464,194 | 0 | 0 | |
ADICET BIO INC | COM | 007002108 | 2,624 | 150,000 | SH | DFND | 1,2,3 | 150,000 | 0 | 0 | |
AIRBNB INC | COM CL A | 009066101 | 7,940 | 47,689 | SH | DFND | 47,689 | 0 | 0 | ||
ALLOT LTD | SHS | M0854Q105 | 4,050 | 340,912 | SH | DFND | 340,912 | 0 | 0 | ||
ALTIMMUNE INC | COM NEW | 02155H200 | 11,397 | 1,244,241 | SH | DFND | 1,2,3 | 1,244,241 | 0 | 0 | |
AMAZON COM INC | COM | 023135106 | 14,004 | 4,200 | SH | DFND | 4,200 | 0 | 0 | ||
ANNEXON INC | COM | 03589W102 | 1,421 | 123,637 | SH | DFND | 1,2,3 | 123,637 | 0 | 0 | |
ARBE ROBOTICS LTD | ORDINARY SHARES | M1R95N100 | 1,120 | 120,400 | SH | DFND | 120,400 | 0 | 0 | ||
ARGENX SE | SPONSORED ADR | 04016X101 | 1,503 | 4,291 | SH | DFND | 1,2,3 | 4,291 | 0 | 0 | |
ARYA SCIENCES ACQU CORP IV | CL A | G31659108 | 9,930 | 1,000,000 | SH | DFND | 1,2,3 | 1,000,000 | 0 | 0 | |
ARYA SCIENCES ACQUISITN CORP | CLASS A ORD SHS | G31658100 | 1,940 | 200,000 | SH | DFND | 1,2,3 | 200,000 | 0 | 0 | |
ASANA INC | CL A | 04342Y104 | 7,194 | 96,500 | SH | DFND | 96,500 | 0 | 0 | ||
ASTRAZENECA PLC | SPONSORED ADR | 046353108 | 61,481 | 1,055,467 | SH | DFND | 1,2,3 | 1,055,467 | 0 | 0 | |
AYALA PHARMACEUTICALS INC | COM | 05465V108 | 2,128 | 250,000 | SH | DFND | 1,2,3 | 250,000 | 0 | 0 | |
BCLS ACQUISITION CORP | COM CL A | G0904B105 | 2,132 | 216,250 | SH | DFND | 1,2,3 | 216,250 | 0 | 0 | |
BIOATLA INC | COM | 09077B104 | 3,534 | 180,006 | SH | DFND | 1,2,3 | 180,006 | 0 | 0 | |
BIOGEN INC | COM | 09062X103 | 3,119 | 13,000 | SH | DFND | 1,2,3 | 13,000 | 0 | 0 | |
BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 19,170 | 216,977 | SH | DFND | 1,2,3 | 216,977 | 0 | 0 | |
BURLINGTON STORES INC | COM | 122017106 | 12,098 | 41,501 | SH | DFND | 41,501 | 0 | 0 | ||
C4 THERAPEUTICS INC | COM STK | 12529R107 | 12,831 | 398,469 | SH | DFND | 1,2,3 | 398,469 | 0 | 0 | |
CAESARSTONE LTD | ORD SHS | M20598104 | 7,305 | 644,146 | SH | DFND | 644,146 | 0 | 0 | ||
CAMTEK LTD | ORD | M20791105 | 3,453 | 75,000 | SH | DFND | 75,000 | 0 | 0 | ||
CELLDEX THERAPEUTICS INC NEW | COM NEW | 15117B202 | 6,444 | 166,766 | SH | DFND | 1,2,3 | 166,766 | 0 | 0 | |
CHINOOK THERAPEUTICS INC | COM | 16961L106 | 1,821 | 111,653 | SH | DFND | 1,2,3 | 111,653 | 0 | 0 | |
COMPASS THERAPEUTICS INC | COM | 20454B104 | 2,219 | 700,000 | SH | DFND | 1,2,3 | 700,000 | 0 | 0 | |
CRINETICS PHARMACEUTICALS IN | COM | 22663K107 | 12,024 | 423,248 | SH | DFND | 1,2,3 | 423,248 | 0 | 0 | |
CYCLACEL PHARMACEUTICALS INC | COM | 23254L603 | 1,977 | 508,322 | SH | DFND | 1,2,3 | 508,322 | 0 | 0 | |
CYTEIR THERAPEUTICS INC | COM | 23284P103 | 1,124 | 98,860 | SH | DFND | 1,2,3 | 98,860 | 0 | 0 | |
DYNE THERAPEUTICS INC | COM | 26818M108 | 1,251 | 105,204 | SH | DFND | 1,2,3 | 105,204 | 0 | 0 | |
ESSA PHARMA INC | COM NEW | 29668H708 | 5,999 | 422,461 | SH | DFND | 1,2,3 | 422,461 | 0 | 0 | |
FATE THERAPEUTICS INC | COM | 31189P102 | 10,852 | 185,476 | SH | DFND | 1,2,3 | 185,476 | 0 | 0 | |
FIVE9 INC | COM | 338307101 | 11,749 | 85,556 | SH | DFND | 85,556 | 0 | 0 | ||
FIVE9 INC | CALL | 338307101 | 24,512 | 178,500 | SH | Call | DFND | 0 | 0 | 178,500 | |
FIVERR INTL LTD | NOTE 11/0 | 33835LAA3 | 12,175 | 13,000,000 | SH | DFND | 13,000,000 | 0 | 0 | ||
GENERAC HLDGS INC | COM | 368736104 | 14,801 | 42,057 | SH | DFND | 42,057 | 0 | 0 | ||
GRAPHITE BIO INC | COM | 38870X104 | 8,244 | 663,194 | SH | DFND | 1,2,3 | 663,194 | 0 | 0 | |
IDEAYA BIOSCIENCES INC | COM | 45166A102 | 5,572 | 235,695 | SH | DFND | 1,2,3 | 235,695 | 0 | 0 | |
IMMATICS N.V | *W EXP 07/01/202 | N44445117 | 439 | 100,000 | SH | DFND | 1,2,3 | 100,000 | 0 | 0 | |
IMMATICS N.V | SHS | N44445109 | 8,359 | 621,925 | SH | DFND | 1,2,3 | 621,925 | 0 | 0 | |
IMMUNIC INC | COM | 4525EP101 | 6,379 | 666,602 | SH | DFND | 1,2,3 | 666,602 | 0 | 0 | |
INHIBRX INC | COM | 45720L107 | 2,705 | 61,931 | SH | DFND | 1,2,3 | 61,931 | 0 | 0 | |
IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 | 5,379 | 281,769 | SH | DFND | 1,2,3 | 281,769 | 0 | 0 | |
IVERIC BIO INC | COM | 46583P102 | 8,109 | 485,001 | SH | DFND | 1,2,3 | 485,001 | 0 | 0 | |
JOHNSON & JOHNSON | COM | 478160104 | 26,537 | 155,123 | SH | DFND | 1,2,3 | 155,123 | 0 | 0 | |
KALVISTA PHARMACEUTICALS INC | COM | 483497103 | 4,183 | 316,200 | SH | DFND | 1,2,3 | 316,200 | 0 | 0 | |
KEROS THERAPEUTICS INC | COM | 492327101 | 7,003 | 119,681 | SH | DFND | 1,2,3 | 119,681 | 0 | 0 | |
KEZAR LIFE SCIENCES INC | COM | 49372L100 | 5,640 | 337,293 | SH | DFND | 1,2,3 | 337,293 | 0 | 0 | |
KURA ONCOLOGY INC | COM | 50127T109 | 11,651 | 832,238 | SH | DFND | 1,2,3 | 832,238 | 0 | 0 | |
KYMERA THERAPEUTICS INC | COM | 501575104 | 20,232 | 318,667 | SH | DFND | 1,2,3 | 318,667 | 0 | 0 | |
LAVA THERAPEUTICS NV | SHS | N51517105 | 758 | 137,857 | SH | DFND | 1,2,3 | 137,857 | 0 | 0 | |
LESLIES INC | COM | 527064109 | 8,815 | 372,569 | SH | DFND | 372,569 | 0 | 0 | ||
LIANBIO | SPONSORED ADS | 53000N108 | 1,662 | 275,007 | SH | DFND | 1,2,3 | 275,007 | 0 | 0 | |
LILLY ELI & CO | COM | 532457108 | 44,111 | 159,695 | SH | DFND | 1,2,3 | 159,695 | 0 | 0 | |
MAGIC SOFTWARE ENTERPRISES L | ORD | 559166103 | 1,208 | 57,704 | SH | DFND | 57,704 | 0 | 0 | ||
MERCK & CO INC | COM | 58933Y105 | 26,550 | 346,423 | SH | DFND | 1,2,3 | 346,423 | 0 | 0 | |
MERUS N V | COM | N5749R100 | 10,842 | 340,951 | SH | DFND | 1,2,3 | 340,951 | 0 | 0 | |
META PLATFORMS INC | CL A | 30303M102 | 14,000 | 41,622 | SH | DFND | 41,622 | 0 | 0 | ||
MICROSOFT CORP | COM | 594918104 | 16,996 | 50,536 | SH | DFND | 50,536 | 0 | 0 | ||
NAUTILUS BIOTECHNOLOGY INC | COM | 63909J108 | 4,144 | 800,000 | SH | DFND | 1,2,3 | 800,000 | 0 | 0 | |
NICE SYS INC | NOTE 1.250% 1/1 | 65366HAB9 | 921 | 250,000 | SH | DFND | 250,000 | 0 | 0 | ||
OMEGA THERAPEUTICS INC | COMMON STOCK | 68217N105 | 3,999 | 352,948 | SH | DFND | 1,2,3 | 352,948 | 0 | 0 | |
ONCORUS INC | COM | 68236R103 | 3,010 | 571,204 | SH | DFND | 1,2,3 | 571,204 | 0 | 0 | |
OTONOMO TECHNOLOGIES LTD | ORDINARY SHARES | M7571L103 | 2,428 | 593,650 | SH | DFND | 593,650 | 0 | 0 | ||
OUTBRAIN INC | COM | 69002R103 | 6,037 | 431,194 | SH | DFND | 431,194 | 0 | 0 | ||
OUTLOOK THERAPEUTICS INC | *W EXP 02/18/202 | 69012T115 | 15 | 129,500 | SH | DFND | 1,2,3 | 129,500 | 0 | 0 | |
PALO ALTO NETWORKS INC | COM | 697435105 | 13,362 | 24,000 | SH | DFND | 24,000 | 0 | 0 | ||
PERION NETWORK LTD | SHS NEW | M78673114 | 5,411 | 225,000 | SH | DFND | 225,000 | 0 | 0 | ||
PFIZER INC | COM | 717081103 | 13,495 | 228,528 | SH | DFND | 1,2,3 | 228,528 | 0 | 0 | |
PMV PHARMACEUTICALS INC | COM | 69353Y103 | 4,401 | 190,525 | SH | DFND | 1,2,3 | 190,525 | 0 | 0 | |
POINT BIOPHARMA GLOBAL INC | COM | 730541109 | 3,319 | 592,592 | SH | DFND | 1,2,3 | 592,592 | 0 | 0 | |
PROTAGONIST THERAPEUTICS INC | CALL | 74366E102 | 8,550 | 250,000 | SH | Call | DFND | 1,2,3 | 0 | 0 | 250,000 |
RELMADA THERAPEUTICS INC | COM | 75955J402 | 10,774 | 478,208 | SH | DFND | 1,2,3 | 478,208 | 0 | 0 | |
SANOFI | SPONSORED ADR | 80105N105 | 54,278 | 1,083,400 | SH | DFND | 1,2,3 | 1,083,400 | 0 | 0 | |
SENTINELONE INC | CL A | 81730H109 | 10,089 | 199,824 | SH | DFND | 199,824 | 0 | 0 | ||
SPDR SER TR | CALL | 78464A870 | 24,631 | 220,000 | SH | Call | DFND | 1,2,3 | 0 | 0 | 220,000 |
SPRINGWORKS THERAPEUTICS INC | COM | 85205L107 | 21,232 | 342,566 | SH | DFND | 1,2,3 | 342,566 | 0 | 0 | |
SUNRUN INC | CALL | 86771W105 | 7,820 | 228,000 | SH | Call | DFND | 0 | 0 | 228,000 | |
SUTRO BIOPHARMA INC | COM | 869367102 | 4,192 | 281,702 | SH | DFND | 1,2,3 | 281,702 | 0 | 0 | |
SYNDAX PHARMACEUTICALS INC | COM | 87164F105 | 25,755 | 1,176,585 | SH | DFND | 1,2,3 | 1,176,585 | 0 | 0 | |
TEVA PHARMACEUTICAL INDS LTD | SPONSORED ADS | 881624209 | 6,671 | 832,877 | SH | DFND | 832,877 | 0 | 0 | ||
TURNING POINT THERAPEUTICS I | COM | 90041T108 | 3,279 | 68,734 | SH | DFND | 1,2,3 | 68,734 | 0 | 0 | |
UNIQURE NV | CALL | N90064101 | 2,074 | 100,000 | SH | Call | DFND | 1,2,3 | 0 | 0 | 100,000 |
VERINT SYS INC | COM | 92343X100 | 10,502 | 200,000 | SH | DFND | 200,000 | 0 | 0 | ||
VERONA PHARMA PLC | SPONSORED ADS | 925050106 | 5,384 | 801,256 | SH | DFND | 1,2,3 | 801,256 | 0 | 0 | |
VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 969 | 4,411 | SH | DFND | 1,2,3 | 4,411 | 0 | 0 | |
VINCERX PHARMA INC | COM NEW | 92731L106 | 7,338 | 720,161 | SH | DFND | 1,2,3 | 720,161 | 0 | 0 | |
VISTAGEN THERAPEUTICS INC | COM NEW | 92840H202 | 7,849 | 4,024,938 | SH | DFND | 1,2,3 | 4,024,938 | 0 | 0 | |
WEREWOLF THERAPEUTICS INC | COM | 95075A107 | 7,722 | 648,391 | SH | DFND | 1,2,3 | 648,391 | 0 | 0 | |
WIX COM LTD | NOTE 8/1 | 92940WAD1 | 17,337 | 18,959,000 | SH | DFND | 18,959,000 | 0 | 0 | ||
ZAI LAB LTD | ADR | 98887Q104 | 7,017 | 111,641 | SH | DFND | 1,2,3 | 111,641 | 0 | 0 |