Santen Pharmaceutical (SNPHY) F-6EF Automatic registration for ADRs (foreign)

Exhibit (e)

Rule 466 Certification

The depositary, Citibank, N.A., represents and certifies the following:

1. That it previously had filed a registration statement on Form F-6 (Registration No. 333-186245), which the U.S. Securities and Exchange Commission declared effective, with terms of deposit identical to the terms of deposit of this Form F-6 Registration Statement except forthe shares represented by the American Depositary Shares and the nameof the issuer of such shares; and

2. That its ability to designate the date and time of effectiveness under Rule 466 has not been suspended.

CITIBANK, N.A., as Depositary
By:	/s/ Robert Franz
	Name:	Robert Franz
	Title:	Vice President

Ex (e)-1