Cover Page
Cover Page - shares | 3 Months Ended | |
Mar. 31, 2023 | May 01, 2023 | |
Cover [Abstract] | ||
Document Type | 10-Q | |
Document Quarterly Report | true | |
Document Period End Date | Mar. 31, 2023 | |
Document Transition Report | false | |
Entity File Number | 001-38295 | |
Entity Registrant Name | X4 PHARMACEUTICALS, INC | |
Entity Incorporation, State or Country Code | DE | |
Entity Tax Identification Number | 27-3181608 | |
Entity Address, Address Line One | 61 North Beacon Street | |
Entity Address, Address Line Two | 4th Floor | |
Entity Address, City or Town | Boston | |
Entity Address, State or Province | MA | |
Entity Address, Postal Zip Code | 02134 | |
City Area Code | 857 | |
Local Phone Number | 529-8300 | |
Title of 12(b) Security | Common Stock | |
Trading Symbol | XFOR | |
Security Exchange Name | NASDAQ | |
Entity Current Reporting Status | Yes | |
Entity Interactive Data Current | Yes | |
Entity Filer Category | Non-accelerated Filer | |
Entity Small Business | true | |
Entity Emerging Growth Company | false | |
Entity Shell Company | false | |
Entity Common Stock, Shares Outstanding | 122,207,488 | |
Amendment Flag | false | |
Document Fiscal Year Focus | 2022 | |
Document Fiscal Period Focus | Q3 | |
Entity Central Index Key | 0001501697 | |
Current Fiscal Year End Date | --12-31 |
CONDENSED CONSOLIDATED BALANCE
CONDENSED CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands | Mar. 31, 2023 | Dec. 31, 2022 |
Current assets: | ||
Cash and cash equivalents | $ 93,406 | $ 121,718 |
Research and development incentive receivable | 658 | 1,152 |
Prepaid expenses and other current assets | 4,158 | 5,807 |
Total current assets | 98,222 | 128,677 |
Property and equipment, net | 986 | 1,104 |
Goodwill | 17,351 | 17,351 |
Right-of-use assets | 6,844 | 7,229 |
Other assets | 1,002 | 1,225 |
Total assets | 124,405 | 155,586 |
Current liabilities: | ||
Accounts payable | 5,992 | 7,777 |
Accrued expenses | 11,762 | 12,034 |
Current portion of lease liability | 1,175 | 1,198 |
Current portion of long-term debt | 554 | 1,315 |
Total current liabilities | 19,483 | 22,324 |
Long-term debt, net of discount and current portion | 31,827 | 32,304 |
Lease liabilities | 3,377 | 3,603 |
Warrant liability (Note 4) | 17,692 | 23,131 |
Other liabilities | 350 | 173 |
Total liabilities | 72,729 | 81,535 |
Commitments and contingencies (Note 9) | ||
Stockholders’ equity: | ||
Common stock, $0.001 par value, 500,000,000 shares authorized as of March 31, 2023 and December 31, 2022, respectively; 122,207,488 and 121,667,250 shares issued and outstanding as of March 31, 2023 and December 31, 2022, respectively | 122 | 122 |
Additional paid-in capital | 452,431 | 450,786 |
Accumulated other comprehensive loss | (119) | (119) |
Accumulated deficit | (400,758) | (376,738) |
Total stockholders’ equity | 51,676 | 74,051 |
Total liabilities and stockholders’ equity | $ 124,405 | $ 155,586 |
CONDENSED CONSOLIDATED BALANC_2
CONDENSED CONSOLIDATED BALANCE SHEETS (Parenthetical) - $ / shares | Mar. 31, 2023 | Dec. 31, 2022 |
Statement of Financial Position [Abstract] | ||
Common stock, par value (in usd per share) | $ 0.001 | $ 0.001 |
Common stock, shares authorized | 500,000,000 | 500,000,000 |
Common stock, shares issued | 122,207,488 | 121,667,250 |
Common stock, shares outstanding | 122,207,488 | 121,667,250 |
CONDENSED CONSOLIDATED STATEMEN
CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) $ in Thousands | 3 Months Ended | |
Mar. 31, 2023 | Mar. 31, 2022 | |
Operating expenses: | ||
Research and development | $ 22,063 | $ 14,113 |
Selling, general and administrative | 7,241 | 7,664 |
Gain (Loss) on Disposition of Assets | 0 | (509) |
Total operating expenses | 29,304 | 21,268 |
Loss from operations | (29,304) | (21,268) |
Other income (expense), net: | ||
Interest income | 835 | 3 |
Interest expense | (1,109) | (913) |
Change in fair value of derivative liability | 5,439 | 176 |
Other income, net | 123 | 60 |
Total other income (expense), net | 5,288 | (674) |
Loss before provision for income taxes | (24,016) | (21,942) |
Provision for income taxes | 4 | 23 |
Net loss and comprehensive loss | (24,020) | (21,965) |
Deemed dividend on Class B Warrant price reset | 0 | (2,259) |
Net loss attributable to common stockholders | $ (24,020) | $ (24,224) |
Net loss per share attributable to common stockholders—basic | $ (0.16) | $ (0.72) |
Net loss per share attributable to common stockholders—diluted | $ (0.16) | $ (0.72) |
Weighted average shares of common stock outstanding—diluted | 145,967,000 | 33,737,000 |
Weighted average shares of common stock outstanding—basic | 145,967,000 | 33,737,000 |
CONDENSED CONSOLIDATED STATEM_2
CONDENSED CONSOLIDATED STATEMENTS OF CONVERTIBLE PREFERRED STOCK, REDEEMABLE COMMON STOCK AND STOCKHOLDERS' EQUITY (DEFICIT) - USD ($) $ in Thousands | Total | Common Stock [Member] | Additional Paid-in Capital [Member] | AOCI Attributable to Parent [Member] | Retained Earnings [Member] |
Beginning balance, shares at Dec. 31, 2021 | 28,127,657 | ||||
Beginning balance at Dec. 31, 2021 | $ 64,412 | $ 28 | $ 347,374 | $ (119) | $ (282,871) |
Increase (Decrease) in Stockholders' Equity [Roll Forward] | |||||
Stock Issued During Period, Shares, New Issues | 2,512,902 | ||||
Stock Issued During Period, Value, New Issues | 5,820 | $ 3 | 5,817 | ||
Restricted Stock, Shares Issued Net of Shares for Tax Withholdings | 168,817 | ||||
Restricted Stock, Value, Shares Issued Net of Tax Withholdings | (12) | (12) | |||
Stock Issued During Period Shares Warrants Exercised | 100 | ||||
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition | 1,459 | 1,459 | |||
Net loss | (21,965) | (21,965) | |||
Ending balance, shares at Mar. 31, 2022 | 30,809,476 | ||||
Ending balance at Mar. 31, 2022 | 49,714 | $ 31 | 354,638 | (119) | (304,836) |
Beginning balance, shares at Dec. 31, 2022 | 121,667,250 | ||||
Beginning balance at Dec. 31, 2022 | 74,051 | $ 122 | 450,786 | (119) | (376,738) |
Increase (Decrease) in Stockholders' Equity [Roll Forward] | |||||
Stock Issued During Period, Shares, New Issues | 540,238 | ||||
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition | 1,645 | 1,645 | |||
Net loss | (24,020) | (24,020) | |||
Ending balance, shares at Mar. 31, 2023 | 122,207,488 | ||||
Ending balance at Mar. 31, 2023 | $ 51,676 | $ 122 | $ 452,431 | $ (119) | $ (400,758) |
CONDENSED CONSOLIDATED STATEM_3
CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 3 Months Ended | ||
Mar. 31, 2023 | Mar. 31, 2022 | ||
Cash flows from operating activities: | |||
Net loss | $ (24,020) | $ (21,965) | |
Adjustments to reconcile net loss to net cash used in operating activities: | |||
Stock-based compensation expense | 1,645 | 1,459 | |
Depreciation and amortization expense | 127 | 133 | |
Non-cash lease expense | 385 | 366 | |
Accretion of debt discount | 225 | 198 | |
Change in fair value of warrant liability | (5,439) | 0 | |
Other | (51) | (120) | |
Changes in operating assets and liabilities: | |||
Prepaid expenses, other current assets and research and development incentive receivable | 2,084 | 1,633 | |
Accounts payable | (1,714) | (713) | |
Accrued expenses | 496 | (984) | |
Lease liabilities | (250) | (236) | |
Net cash used in operating activities | (26,512) | (20,229) | |
Cash flows from investing activities: | |||
Acquisition of property and equipment | (9) | (22) | |
Net cash used in investing activities | (9) | (22) | |
Cash flows from financing activities: | |||
Employee taxes paid related to net share settlement of vested restricted stock units | 0 | (12) | |
Fees paid to amendment loan and security agreement and issuance costs related to the sale of warrants | (381) | (114) | |
Repayments of Secured Debt | (1,300) | (795) | |
Proceeds from sale of shares of common stock, and pre-funded warrants, net of issuance costs (1) | [1] | 5,877 | |
Payments for Repurchase of Common Stock | [1] | (443) | |
Net cash (used in) provided by financing activities | (2,124) | 4,956 | |
Effect of exchange rate changes on cash, cash equivalents and restricted cash | 50 | (69) | |
Net decrease in cash, cash equivalents and restricted cash | (28,595) | (15,364) | |
Cash, cash equivalents and restricted cash at beginning of period | 123,028 | 83,108 | |
Cash, cash equivalents and restricted cash at end of period | $ 94,433 | $ 67,744 | |
[1](1) For the three month period ended March 31, 2023, includes payment of issuance costs related to December 2022 public sale of shares of common stock and pre-funded warrants |
CONDENSED CONSOLIDATED STATEM_4
CONDENSED CONSOLIDATED STATEMENTS OF CONVERTIBLE PREFERRED STOCK, REDEEMABLE COMMON STOCK AND STOCKHOLDERS' EQUITY (DEFICIT) (Parenthetical) $ in Thousands | 3 Months Ended |
Dec. 31, 2022 USD ($) | |
Statement of Stockholders' Equity [Abstract] | |
Issuance costs |
Nature of the Business and Basi
Nature of the Business and Basis of Presentation | 3 Months Ended |
Mar. 31, 2023 | |
Organization, Consolidation and Presentation of Financial Statements [Abstract] | |
Nature of the Business and Basis of Presentation | NATURE OF THE BUSINESS AND BASIS OF PRESENTATION X4 Pharmaceuticals, Inc. (together with its subsidiaries, the “Company”) is a late-stage clinical biopharmaceutical company focused on the research and development of novel therapeutics for the treatment of rare diseases and those with limited treatment options, with a focus on conditions resulting from dysfunction of the immune system. The Company’s lead clinical candidate is mavorixafor, a small molecule antagonist of the chemokine receptor CXCR4 that is being developed as an oral, once-daily therapy. Due to its ability to increase the mobilization of mature, functional white blood cells from the bone marrow into the bloodstream, the Company believes that mavorixafor has the potential to provide therapeutic benefit across a variety of chronic neutropenic disorders, including WHIM (Warts, Hypogammaglobulinemia, Infections, and Myelokathexis (“WHIM”)) syndrome, a rare, primary immunodeficiency, and certain cancers. Following announcement of positive top-line data from the Company’s global, pivotal, Phase 3 clinical trial in November 2022, the Company is preparing a United States regulatory submission seeking approval of oral, once-daily mavorixafor in the treatment of people aged 12 years and older with WHIM syndrome. The Company is also currently enrolling participants in a Phase 2 clinical trial in people with certain chronic neutropenic disorders following positive results from a Phase 1b clinical trial evaluating mavorixafor in people with idiopathic, cyclic, or congenital neutropenia that were presented in the third quarter of 2022. The Company also conducted a proof-of-concept Phase 1b clinical trial of mavorixafor in combination with ibrutinib in people with Waldenström’s macroglobulinemia (“Waldenström’s”), a rare form of lymphoma. The Company reported positive results from the Waldenström’s Phase 1b trial in the third quarter of 2022 and concluded the trial in December 2022. Any further studies of mavorixafor in Waldenström’s or other oncology indication will be subject to completing a strategic partnership. The Company is headquartered in Boston, Massachusetts and has an additional facility in Vienna, Austria. Going Concern Assessment— In accordance with Accounting Standards Update (“ASU”) No. 2014-15, Disclosure of Uncertainties about an Entity’s Ability to Continue as a Going Concern (Subtopic 205-40) (“ASU 2014-15”), the Company has evaluated whether there are certain conditions and events, considered in the aggregate, that raise substantial doubt about the Company’s ability to continue as a going concern within one year after the date that the condensed consolidated financial statements are issued. Since inception, the Company has incurred significant operating losses and negative cash flows from operations. As of March 31, 2023, the Company had $93.4 million of cash and cash equivalents, an accumulated deficit of $400.8 million and net cash used in operating activities of $26.5 million. The Company has a covenant under its Second Amended and Restated Loan and Security Agreement with Hercules Capital Inc. (“Hercules”) that requires that the Company maintain a minimum level of cash of $20 million, subject to reduction to $10 million upon the achievement of operational milestones. Based on its current cash flow projections and with no additional funding, the Company believes it will not be able to maintain the minimum cash required to satisfy this covenant beginning in the first quarter of 2024. In such event, the lender could require the repayment of all outstanding debt. Management has assessed the Company’s ability to continue as a going concern in accordance with the requirements of ASC 205-40 and determined that the Company’s accumulated deficit, history of losses and future expected losses met the ASC 205-40 standard for raising substantial doubt about the Company’s ability to continue as a going concern. The Company does not have adequate financial resources to fund its forecasted operating costs for at least one year after the date that these condensed consolidated financial statements are issued. The accompanying condensed consolidated financial statements do not include any adjustments relating to the recoverability and classification of recorded asset amounts or the amounts and classification of liabilities that might result from the outcome of this uncertainty. Accordingly, the condensed consolidated financial statements have been prepared on a basis that assumes the Company will continue as a going concern, which contemplates the realization of assets and satisfaction of liabilities and commitments in the ordinary course of business. To finance its operations, the Company will need to raise additional capital, which cannot be assured. Unless and until the Company reach’s profitability in the future, it will require additional capital to fund our operations, which could be raised through a combination of equity offerings, debt financings, other third-party funding, marketing and distribution arrangements and other collaborations and strategic alliances. If the Company is unable to obtain funding, it could be forced to delay, reduce or eliminate some or all of its research and development programs, product portfolio expansion or commercialization efforts, which would adversely affect its business prospects, or it may be unable to continue operations. Principles of Consolidation— The condensed consolidated financial statements include the accounts of the Company and its wholly-owned subsidiaries, including X4 Pharmaceuticals (Austria) GmbH, which is incorporated in Vienna, Austria (“X4 Austria”), and X4 Therapeutics, Inc. All significant intercompany accounts and transactions have been eliminated. Unaudited Interim Condensed Consolidated Financial Statements— The condensed consolidated balance sheet at December 31, 2022 that is presented in these interim condensed consolidated financial statements was derived from audited financial statements but does not include all disclosures required by accounting principles generally accepted in the United States of America (“GAAP”). The accompanying condensed consolidated financial statements are unaudited. The accompanying unaudited interim condensed consolidated financial statements have been prepared by the Company pursuant to the rules and regulations of the Securities and Exchange Commission (“SEC”) for interim financial statements. Accordingly, certain information and footnote disclosures normally included in financial statements prepared in accordance with GAAP have been condensed or omitted pursuant to such rules and regulations. However, the Company believes that the disclosures are adequate to make the information presented not misleading. These unaudited interim condensed consolidated financial statements should be read in conjunction with the Company’s audited financial statements and the notes thereto for the year ended December 31, 2022 included in the 2022 Annual Report filed with the SEC on March 21, 2023. In the opinion of management, all adjustments, consisting only of normal recurring adjustments as necessary, for the fair statement of the Company’s condensed financial position, condensed results of its operations and cash flows have been made. The results of operations for the three months ended March 31, 2023 are not necessarily indicative of the results of operations that may be expected for the year ending December 31, 2023. Use of Estimates— The preparation of the Company’s consolidated financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities, the disclosure of contingent assets and liabilities at the date of the consolidated financial statements, and the reported amounts of expenses during the reporting period. Significant estimates and assumptions reflected in these consolidated financial statements include, but are not limited to, the accrual of research and development expenses, the impairment or lack of impairment of long-lived assets including operating lease right-of-use assets and goodwill, and assumptions underlying the fair value of warrant liabilities. The Company bases its estimates on historical experience, known trends and other market-specific or other relevant factors that it believes to be reasonable under the circumstances. On an ongoing basis, management evaluates its estimates when there are changes in circumstances, facts and experience. Changes in estimates are recorded in the period in which they become known. As of the date of issuance of these consolidated financial statements, the Company is not aware of any specific event or circumstance that would require the Company to update its estimates, assumptions and judgments or revise the carrying value of its assets or liabilities. Actual results could differ from those estimates, and any such differences may be material to the Company’s consolidated financial statements. |
Summary of Significant Accounti
Summary of Significant Accounting Policies | 3 Months Ended |
Mar. 31, 2023 | |
Accounting Policies [Abstract] | |
Summary of Significant Accounting Policies | SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES Significant Accounting Policies— The Company’s significant accounting policies are disclosed in the audited consolidated financial statements and the notes thereto in the Company’s Annual Report on Form 10-K for the year ended December 31, 2022 filed with the SEC on March 21, 2023. Since the date of those consolidated financial statements, there have been no material changes to the Company’s significant accounting policies. Cash and Cash Equivalents— The Company considers all highly liquid investments with maturities of three months or less at the date of purchase to be cash equivalents. Cash equivalents consisted of money market funds as of March 31, 2023 and December 31, 2022. Restricted Cash (in thousands) As of March 31, 2023 As of December 31, 2022 Letter of credit security: Waltham lease $ 250 $ 250 Letter of credit security: Vienna Austria lease 206 205 Letter of credit security: Boston lease 571 855 Total restricted cash $ 1,027 $ 1,310 Restricted cash included in prepaid expenses and other current assets $ 250 $ 285 Restricted cash included in other assets $ 777 $ 1,025 In connection with the Company’s lease agreements for its facilities in Massachusetts and Austria, the Company maintains letters of credit, which are secured by restricted cash, for the benefit of the respective landlord. The following table provides a reconciliation of cash, cash equivalents, and restricted cash reported within the condensed consolidated balance sheets to the sum of the total of amounts shown in the Company’s condensed consolidated statements of cash flows as of March 31, 2023 and December 31, 2022: (in thousands) March 31, 2023 December 31, 2022 Cash and cash equivalents $ 93,406 $ 121,718 Restricted cash, current portion 250 285 Restricted cash, non-current 777 1,025 Total cash, cash equivalents and restricted cash $ 94,433 $ 123,028 Goodwill— Goodwill is tested for impairment at the reporting unit level annually in the fourth quarter, or more frequently when events or changes in circumstances indicate that the asset might be impaired. Examples of such events or circumstances include, but are not limited to, a significant adverse change in legal or business climate, an adverse regulatory action or unanticipated competition. The Company has determined that it operates in a single operating segment and has a single reporting unit. The Company assesses qualitative factors to determine whether the existence of events or circumstances would indicate that it is more likely than not that the fair value of the reporting unit is less than its carrying amount. If after assessing the totality of events or circumstances, the Company were to determine that it is more likely than not that the fair value of the reporting unit is less than its carrying amount, then the Company would perform an interim quantitative impairment test, whereby the Company compares the fair value of the reporting unit to its carrying value. If the fair value of the reporting unit exceeds the carrying value of its net assets, goodwill is not impaired, and no further testing is required. If the fair value of the reporting unit is less than its carrying value, the Company measures the amount of impairment loss, if any, as the excess of the carrying value over the fair value of the reporting unit . There were no triggering events during the three months ended March 31, 2023 that necessitated an interim impairment test of goodwill. Recently Adopted Accounting Standards In June 2016, the Financial Accounting Standards Board issued ASU 2016-13, Credit Losses (Topic 326) Measurement of Credit Losses on Financial Instruments |
License, Collaboration, and Fun
License, Collaboration, and Funding Agreements | 3 Months Ended |
Mar. 31, 2023 | |
Organization, Consolidation and Presentation of Financial Statements [Abstract] | |
License, Collaboration, and Funding Agreements | LICENSE, COLLABORATION AND FUNDING AGREEMENTS Research and Development Incentive Program The Company participates in a research and development incentive program provided by the Austrian government whereby the Company is entitled to reimbursement by the Austrian government for a percentage of qualifying research and development expenses and capital expenditures incurred by the Company’s subsidiary in Austria. As of March 31, 2023, the amount due under the program is $0.7 million, which amount is included in research and development incentive receivable in the condensed consolidated balance sheet. During the three months ended March 31, 2023 and 2022, the Company recorded $121.0 thousand and $135.3 thousand, respectively, of income related to the program within the condensed consolidated statements of operations as other income. License and Collaboration Agreements In July 2014, the Company entered into a license agreement with Genzyme (the “Genzyme Agreement”) pursuant to which the Company was granted an exclusive license to certain patents and intellectual property owned or controlled by Genzyme related to the CXCR4 receptor to develop and commercialize products containing licensed compounds (including but not limited to mavorixafor) for all therapeutic, prophylactic and diagnostic uses, with the exception of autologous and allogenic human stem cell therapy. Under the terms of the Genzyme Agreement, the Company is obligated to use commercially reasonable efforts to develop and commercialize licensed products for use in the field in the United States and at least one other major market country. The Company is obligated to pay Genzyme milestone payments in the aggregate amount of up to $25.0 million, contingent upon the achievement by the Company of certain clinical-stage regulatory and sales milestones with respect to licensed products. During three months ended March 31, 2023, the Company accrued $5.0 million related to a development milestone under the Genzyme Agreement as the Company believes that it is probable under ASC Topic 450, Contingencies , that the milestone will be achieved. The $5.0 million accrued payment has been recorded within research and development expense on the condensed consolidated statements of operations. An additional $7.0 million of regulatory milestone payments are not yet probable but are reasonably possible of becoming payable with the next twelve to eighteen month period under the Genzyme Agreement. The Company is also obligated to pay Genzyme tiered royalties based on net sales of licensed products that the Company commercializes under the agreement. Gain on Sale of Non-Financial Asset During the three months ended March 31, 2022, a third party, who had previously acquired rights to certain intellectual property from the Company, terminated the arrangement and transferred these rights back to the Company. Also during the three months ended March 31, 2022, the Company transferred these rights to another third party in return for $0.5 million. The Company has no continuing involvement in any ongoing research and development activities associated with the intellectual property. The Company concluded that these third parties are "non-customers" as the underlying intellectual property transferred to and from these third parties supports potential drug candidates that are not aligned with the Company's strategic focus and, therefore, are not an output of the Company's ordinary activities. Accordingly, the Company accounted for the sale of the intellectual property as the sale of a non-financial asset under ASC Topic 610-20, Gains and Losses from the Derecognition of Nonfinancial Assets ("ASC 610-20"), and included the gain in gain on sale of non-financial asset for the three months ended March 31, 2022. There were no material modifications of the Company’s license or collaboration agreements during the three months ended March 31, 2023. |
Fair Value of Financial Assets
Fair Value of Financial Assets and Liabilities | 3 Months Ended |
Mar. 31, 2023 | |
Fair Value Disclosures [Abstract] | |
Fair Value of Financial Assets and Liabilities | FAIR VALUE OF FINANCIAL ASSETS AND LIABILITIES The following tables present information about the Company’s financial assets and liabilities measured at fair value on a recurring basis and indicate the level of the fair value hierarchy used to determine such fair values: Fair Value Measurements as of March 31, 2023 Using: (in thousands) Level 1 Level 2 Level 3 Total Assets: Cash equivalents—money market funds $ 70,959 $ 14 $ — $ 70,973 $ 70,959 $ 14 $ — $ 70,973 Liabilities: Embedded derivative liability $ — $ — $ 10 $ 10 Class C warrant liability — — 17,692 17,692 $ — $ — $ 17,702 $ 17,702 Fair Value Measurements as of December 31, 2022 Using: (in thousands) Level 1 Level 2 Level 3 Total Assets: Cash equivalents—money market funds $ 70,170 $ 2,858 $ — $ 73,028 $ 70,170 $ 2,858 $ — $ 73,028 Liabilities: Embedded derivative liability $ — $ — $ 10 $ 10 Class C warrant liability — — 23,131 23,131 $ — $ — $ 23,141 $ 23,141 The Company’s cash equivalents consisted of money market funds invested primarily in short term commercial paper, asset- backed securities, certificate of deposits and repurchase agreements. The money market funds were valued based on reported market pricing for the identical assets, which represents a Level 1 measurement, or by using inputs observable in active markets for similar securities, which represents a Level 2 measurement. The following table provides a roll-forward of the aggregate fair values financial instruments for which fair values are determined using Level 3 inputs: (in thousands) Embedded Derivative Liability Class C Warrant Liability Total Balance as of December 31, 2022 $ 10 $ 23,131 $ 23,141 Change in fair value — (5,439) (5,439) Balance as of March 31, 2023 $ 10 $ 17,692 $ 17,702 Embedded Derivative Liability — The fair value of the embedded derivative liability recognized in connection with the Company’s loan agreement with Hercules (see Note 7), which is associated with additional fees due to Hercules upon events of default, was determined based on significant inputs not observable in the market, which represents a Level 3 measurement within the fair value hierarchy. The fair value of this embedded derivative liability, which is reported within other non-current liabilities on the condensed consolidated balance sheets, is estimated by the Company at each reporting date based, in part, on the results of third party valuations, which are prepared based on a discounted cash flow model that considers the timing and probability of occurrence of a redemption upon an event of default, the potential amount of prepayment fees or contingent interest upon an event of default and the Company’s risk-adjusted discount rate of 14%. Class C Warrant Liability — In December 2022, the Company issued Class C Warrants for the purchase of shares of its common stock in a public offering of common stock. The Class C Warrants are accounted for as a liability on the condensed consolidated balance sheet and are adjusted to fair value at period end through “other income (expense)” in the condensed, consolidated statements of operations and comprehensive loss. The Company calculated the fair value of the Class C Warrants using the Black-Scholes option pricing model, which represents a Level 3 measurement within the fair value hierarchy, with the following inputs: March 31, 2023 December 31, 2022 Common stock price $0.87 $0.99 Risk-free interest rate 3.9 % 4.0 % Expected term (in years) 4.7 years 4.9 years Expected volatility 91.9 % 101.7 % Expected dividend yield — % — % |
Property and Equipment, Net
Property and Equipment, Net | 3 Months Ended |
Mar. 31, 2023 | |
Property, Plant and Equipment [Abstract] | |
Property and Equipment, Net | PROPERTY AND EQUIPMENT, NET Property and equipment, net consisted of the following: (in thousands) March 31, 2023 December 31, 2022 Leasehold improvements $ 228 $ 228 Furniture and fixtures 1,274 1,268 Computer equipment 173 173 Software 24 24 Lab equipment 642 639 2,341 2,332 Less: Accumulated depreciation and amortization (1,355) (1,228) $ 986 $ 1,104 Depreciation and amortization expense related to property and equipment was $127 thousand and $133 thousand for the three months ended March 31, 2023 and 2022, respectively. |
Accrued Expenses
Accrued Expenses | 3 Months Ended |
Mar. 31, 2023 | |
Payables and Accruals [Abstract] | |
Accrued Expenses | ACCRUED EXPENSES Accrued expenses consisted of the following: (in thousands) March 31, December 31, Accrued employee compensation and benefits $ 2,742 6,592 Accrued external research and development expenses 7,721 3,906 Accrued professional fees 924 571 Accrued deferred financing fees — 591 Other 375 374 $ 11,762 $ 12,034 |
Long-Term Debt
Long-Term Debt | 3 Months Ended |
Mar. 31, 2023 | |
Debt Disclosure [Abstract] | |
Long-Term Debt | Long-term debt consisted of the following: (in thousands) March 31, December 31, Principal amount of long-term debt $ 32,500 $ 32,500 Debt discount, net of accretion (767) (196) Cumulative accretion of end of term payments 648 1,315 Long-term debt $ 32,381 $ 33,619 Less: current portion $ (554) $ (1,315) Long-term debt, net of current portion $ 31,827 $ 32,304 Hercules Loan Agreement, As Amended In October 2018, the Company entered into a Loan and Security Agreement (the “Hercules Loan Agreement”), as amended most recently in January 2023, with Hercules, under which the Company has borrowed an aggregate of $32.5 million of term loans to date representing the maximum borrowings. Borrowings under the Hercules Loan Agreement accrues interest at a variable rate equal to the greater of (i) 10.15% or (ii) The Wall Street Journal prime rate plus 3.15%. In an event of default and until such event is no longer continuing, the interest rate applicable to borrowings would be increased by 4.0%. Borrowings under the Hercules Loan Agreement are repayable in monthly interest-only payments through September 2024, and in equal monthly payments of principal and accrued interest from October 1, 2024 until the maturity date of the loan on April 1, 2026; provided, however, if certain conditions are met and the Company achieves certain operational and financial milestones, the maturity date will be extended to July 1, 2027. The Company may prepay all, but not less than all, of the outstanding borrowings, subject to a prepayment premium of 3.0% of the principal amount outstanding as of the date of repayment. In addition, the Hercules Loan Agreement provides for payments of $0.8 million and $1.3 million payable on July 1, 2023 and April 1, 2026, respectively, which payments are accelerated upon the prepayment of the borrowings upon the Company’s election or upon default of the loan. Borrowings under the Hercules Loan Agreement are collateralized by substantially all of the Company’s personal property and other assets except for its intellectual property (but including rights to payment and proceeds from the sale, licensing or disposition of the intellectual property). Under the Hercules Loan Agreement, the Company has agreed to affirmative and negative covenants. Pursuant to the Hercules Loan Agreement, the Company is required to maintain cash in an account or accounts in which Hercules has a first priority security interest, in an aggregate amount greater than $20.0 million. Upon the FDA’s approval of the sale and marketing of mavorixafor for the treatment to patients with WHIM syndrome with a label claim that is generally consistent with that sought in the Company’s New Drug Application filing, the required level shall be reduced to $10.0 million. A breach of any of the covenants under the Hercules Loan Agreement could result in a default under the loan. Upon the occurrence of an event of default under the loan facility with Hercules, the lender could elect to declare all amounts outstanding, if any, to be immediately due and payable and terminate all commitments to extend further credit. If there are any amounts outstanding that the Company is unable to repay, Hercules could proceed against the collateral to secure such indebtedness. The Hercules Loan Agreement also restricts the Company’s ability to incur additional indebtedness, pay dividends, encumber its intellectual property, or engage in certain fundamental business transactions, such as mergers or acquisitions of other businesses, with certain exceptions. The Company recognized interest expense under the Hercules Loan Agreement as follows: (in thousands) Three Months Ended March 31, 2023 2022 Total interest expense $ 884 $ 909 Non-cash interest expense $ 225 $ 198 The annual effective interest rate of the Hercules Loan Agreement as of March 31, 2023 is 13.8%. There were no principal payments due or paid under the Hercules Loan Agreement during the three months ended March 31, 2023. An end-of-term payment of $1.3 million was paid during the three months ended March 31, 2023 in conjunction with the second amendment and restatement of the Hercules Loan Agreement, which was entered into on January 6, 2023. The Company concluded that the amendment and restatement represented a modification to the debt. Accordingly, fees paid to third parties directly related to the amended and restated debt were expensed as incurred and fees paid to Hercules in conjunction with the amendment and restatement were deferred and are being amortized to interest expense over the life of the debt arrangement using the effective interest method. As of March 31, 2023, future principal and accrued end-of-term payments due under the Hercules Loan Agreement were as follows (in thousands): Year Ending December 31, Total 2023 $ 554 2024 4,750 2025 20,386 2026 7,458 Long-term debt $ 33,148 |
Leases
Leases | 3 Months Ended |
Mar. 31, 2023 | |
Leases [Abstract] | |
Leases | LEASES The Company has lease agreements for its facilities in Boston, Massachusetts, which is the Company’s principal executive office; Vienna, Austria, which is the Company’s research and development center; and Waltham, Massachusetts, which the Company has sublet to a third party. There are no restrictions or financial covenants associated with any of the lease agreements. • Vienna Austria Leases— The Company has an operating lease for approximately 1,200 square meters of laboratory and office space in Vienna, Austria (“Vienna Lease”), which commenced in February 2021 for a term of 7 years. The annual base rent for the Vienna Lease is approximately $285 thousand. • Boston Lease — The Company leases approximately 28,000 square feet of office space in Boston, Massachusetts (“Boston Lease”), which serves as the Company’s headquarters. Base rental payments are approximately $1.1 million annually, plus certain operating expenses. The term of the Boston Lease will continue until November 2026, unless earlier terminated. The Company has the right to sublease the premises, subject to landlord consent and also has the right to renew the Boston Lease for an additional five years at the then prevailing effective market rental rate. The Company is required to maintain a security deposit in the form of a letter of credit for $0.6 million for the benefit of the landlord. • Waltham Lease— The Company leases approximately 6,000 square feet of office space in Waltham, Massachusetts (“Waltham Lease”). The Waltham Lease, as amended, commenced on January 1, 2019, and expires on December 31, 2023. The base rent is approximately $0.3 million annually. In addition to the base rent, the Company is also responsible for its share of operating expenses, electricity and real estate taxes, which costs are not included in the determination of the leases’ right-of-use assets or lease liabilities. The Company is subleasing the space to a third party for the duration of the lease. The right-of-use asset is being amortized to rent expense over the five-year term of the lease. As the Company’s leases do not provide an implicit rate, the Company estimated the incremental borrowing rate in calculating the present value of the lease payments. The Company utilizes its incremental borrowing rates, which are the rates incurred to borrow on a collateralized basis over a similar term and amount equal to the lease payments in a similar economic environment. The components of lease expense for the three months ended March 31, 2023 and 2022 were as follows: (dollars in thousands) Three Months Ended March 31, Lease Cost 2023 2022 Fixed operating lease cost $ 522 $ 530 Total lease expense $ 522 $ 530 Other information Operating cash flows from operating leases $ 346 $ 342 Sublease income $ 49 $ 49 Weighted-average remaining lease term—operating leases 3.8 years Weighted-average discount rate—operating leases 11.3 % Maturities of lease liabilities due under lease agreements that have commenced as of March 31, 2023 are as follows (in thousands) Maturity of lease liabilities Operating 2023 (remainder of the year) $ 1,210 2024 1,378 2025 1,406 2026 1,337 2027 285 Thereafter 48 Total lease payments 5,664 Less: interest (1,112) Total operating lease liabilities as of March 31, 2023 $ 4,552 |
Commitment and Contingencies
Commitment and Contingencies | 3 Months Ended |
Mar. 31, 2023 | |
Commitments and Contingencies Disclosure [Abstract] | |
Commitment and Contingencies | COMMITMENTS AND CONTINGENCIES The Company has agreements with contract manufacturing organizations (“CMOs”) for the production of mavorixafor for use in clinical trials. The Company’s agreement with the CMO who produces batches of drug substance for use in the Company’s clinical drug supply contains cancellation provisions that would require the Company to pay up to the full contract value upon cancellation. As of March 31, 2023, the Company has approximately $0.8 million of such commitments in place subject to cancellation provisions. Indemnification Agreements— In the ordinary course of business, the Company may provide indemnification of varying scope and terms to vendors, lessors, business partners and other parties with respect to certain matters including, but not limited to, losses arising out of breach of such agreements or from intellectual property infringement claims made by third parties. In addition, the Company has entered into indemnification agreements with members of its board of directors and its executive officers that will require the Company to, among other things, indemnify them against certain liabilities that may arise by reason of their status or service as directors or officers. The maximum potential amount of future payments the Company could be required to make under these indemnification agreements is, in many cases, unlimited. To date, the Company has not incurred any material costs as a result of such indemnification obligations. The Company is not currently aware of any indemnification claims and has not accrued any liabilities related to such obligations in its condensed consolidated financial statements as of March 31, 2023 or December 31, 2022. Legal Proceedings— The Company is not a party to any litigation and does not have contingency reserves established for any litigation liabilities. At each reporting date, the Company evaluates whether or not a potential loss amount or a potential range of loss is probable and reasonably estimable under the provisions of the authoritative guidance that addresses accounting for contingencies. The Company expenses as incurred the costs related to any legal proceedings. |
Common Stock Warrants
Common Stock Warrants | 3 Months Ended |
Mar. 31, 2023 | |
Equity [Abstract] | |
Common Stock Warrants | COMMON STOCK AND COMMON STOCK WARRANTS As of March 31, 2023, the Company’s Restated Certificate of Incorporation authorized the Company to issue 500 million shares of common stock, par value $0.001 per share. The voting, dividend and liquidation rights of the holders of the Company’s common stock are subject to and qualified by the rights, powers and preferences of the holders of any preferred stock that may be issued. Each share of common stock entitles the holder to one vote on all matters submitted to a vote of the Company’s stockholders. Common stockholders are entitled to receive dividends, as may be declared by the board of directors, if any. No cash dividends have been declared or paid to date. In connection with previous public and private sales of shares of its common stock, the Company has issued warrants and pre-funded warrants, which are exercisable for the purchase shares of the Company’s common stock. All outstanding warrants and pre-funded warrants are currently exercisable and do not have price reset provisions. Upon the closing of these public and private offerings, the Company received approximately 99% of the exercise price for the pre-funded warrants, for which the remaining exercise price is equal to or less than $0.01 per share. As of March 31, 2023, the Company’s outstanding warrants and pre-funded warrants to purchase shares of common stock consisted of the following: Issuance Date Number of Exercise Expiration Date October 25, 2016 5,155 $ 19.78 October 24, 2026 December 28, 2017 115,916 $ 19.78 December 28, 2027 September 12, 2018 20,220 $ 19.78 September 12, 2028 October 19, 2018 20,016 $ 19.78 October 19, 2028 March 13, 2019 5,000 $ 19.78 March 12, 2029 April 16, 2019 3,866,154 $ 13.20 April 15, 2024 November 29, 2019 1,250,000 $ 12.00 (a) n/a March 23, 2021 50,000 $ 8.70 (b) n/a November 9, 2021 2,008,032 $ 4.98 (c) n/a March 3, 2022 766,666 $ 1.80 (d) n/a July 6, 2022 13,276,279 $ 1.095 (e) n/a July 6, 2022 50,925,365 $ 1.095 July 6, 2027 December 9, 2022 32,762,947 $ 1.50 December 9, 2027 December 9, 2022 6,800,000 $ 1.10 (f) n/a 111,871,750 (a) In November 2019, the Company received $11.999 per pre-funded warrant, or $21.0 million in aggregate proceeds. Each pre-funded |
Stock-Based Compensation
Stock-Based Compensation | 3 Months Ended |
Mar. 31, 2023 | |
Share-Based Payment Arrangement [Abstract] | |
Stock-Based Compensation | STOCK-BASED COMPENSATION Summary of Plans— The Company has the following equity incentive plans: • The X4 Pharmaceuticals Inc. 2015 Employee, Director and Consultant Equity Incentive Plan, as amended (the “2015 Plan”); • The X4 Pharmaceuticals Inc. 2017 Equity Incentive Plan (the “2017 Plan”); and • The X4 Pharmaceuticals Inc. 2019 Inducement Equity Incentive Plan (the “2019 Plan”) The Company also has the following employee stock purchase plan: • The X4 Pharmaceutical Inc. 2017 Employee Stock Purchase Plan (the “2017 ESPP”) These plans are administered by the Board of Directors or by a committee of the Board of Directors. The exercise prices, vesting and other restrictions are determined at the discretion of the Board of Directors, or its committee if so delegated, except that the exercise price per share of stock options may not be less than 100% of the fair market value of the share of common stock on the date of grant and the term of the stock option may not be greater than ten years. Incentive stock options granted to employees and restricted stock awards granted to employees, officers, members of the board of directors, advisors, and consultants of the Company typically vest over four years. Non-statutory options granted to employees, officers, members of the board of directors, advisors, and consultants of the Company typically vest over three or four years. Shares that are expired, terminated, surrendered or canceled under the Plans without having been fully exercised will be available for future awards. In addition, shares of common stock that are tendered to the Company by a participant to exercise an award are added to the number of shares of common stock available for the grant of awards. As of March 31, 2023, there are an aggregate of approximately 1.0 million shares of common stock available for issuance under the Company’s equity incentive plans. Approximately 150,000 shares of common stock remain available for issuance under the 2017 ESPP. Stock Option Valuation— The following table presents, on a weighted average basis, the assumptions used in the Black-Scholes option-pricing model to determine the grant-date fair value of stock options granted to employees, directors and non-employees. Three Months Ended March 31, 2023 2022 Risk-free interest rate 3.6 % 2.0 % Expected term (in years) 6.0 6.1 Expected volatility 90.8 % 94.5 % Expected dividend yield 0 % 0 % Stock Options The following table summarizes the Company’s stock option activity for the three months ended March 31, 2023: Number of Weighted Weighted Aggregate Outstanding as of December 31, 2022 2,021,480 $ 6.99 6.5 $ 1 Granted 834,900 0.90 Forfeited and Expired (26,080) 8.68 Outstanding as of March 31, 2023 2,830,300 $ 5.18 8.0 $ — Exercisable as of March 31, 2023 1,163,500 $ 9.72 6.1 $ — Vested and expected to vest as of March 31, 2023 2,210,011 $ 6.20 7.6 $ — There were no stock options exercised in the three months ended March 31, 2023 and 2022. The weighted average grant-date fair value per share of stock options granted during the three months ended March 31, 2023 and 2022 was $0.69 and $1.42, respectively. Restricted Stock Units— The following table summarizes the Company's restricted stock unit activity for the three months ended March 31, 2023: Number of Unvested as of December 31, 2022 1,680,563 Granted 4,694,691 Vested (540,238) Unvested as of March 31, 2023 5,835,016 During the three months ended March 31, 2023, the Company granted performance-based restricted stock units (“PRSUs”) to its employees. The PRSUs vest 50% based on the Company’s achievement of each of two operational milestones conditioned on the grantee’s continued employment with the Company. As of March 31, 2023, neither of the two performance criteria had been met. The Company believes that the achievement of these operational milestones is probable and, accordingly, stock-based compensation expense has been recognized for the awards using the accelerated attribution model based on the fair value of the awards as of the date of grant and management’s best estimate of the date each operational milestone will be achieved. The Company will update its estimates related to the probability and timing of achievement of the operational milestones each period until the award either vests or is forfeited. Stock-Based Compensation— As of March 31, 2023, total unrecognized compensation expense related to unvested stock options and restricted stock units was $6.2 million, which is expected to be recognized over a weighted average period of 1.3 years. Stock-based compensation expense was classified in the condensed consolidated statements of operations as follows: Three Months Ended March 31, (in thousands) 2023 2022 Research and development expense $ 831 $ 704 Selling, general and administrative expense 814 755 Total stock-based compensation $ 1,645 $ 1,459 |
Income Taxes
Income Taxes | 3 Months Ended |
Mar. 31, 2023 | |
Income Tax Disclosure [Abstract] | |
Income Taxes | INCOME TAXESThe Company did not record a U.S. federal or state income tax benefit for its losses for the three months ended March 31, 2023 and 2022, due to the conclusion that a full valuation allowance is required against the Company’s U.S. federal and state deferred tax assets. For the three months ended March 31, 2023 and 2022, the Company recorded an immaterial income tax provision related to its Austrian subsidiary. |
Net Loss per Share
Net Loss per Share | 3 Months Ended |
Mar. 31, 2023 | |
Earnings Per Share [Abstract] | |
Net Loss per Share | NET LOSS PER SHARE Basic and diluted net loss per share attributable to common stockholders was calculated as follow: Three Months Ended March 31, (in thousands, except per share data) 2023 2022 Numerator: Net loss $ (24,020) $ (21,965) Deemed dividend as a result of Class B warrant price reset — (2,259) Net loss attributable to common stockholders $ (24,020) $ (24,224) Denominator: Weighted average shares of common stock outstanding—basic and diluted 145,967 33,737 Net loss per share attributable to common stockholders— basic and diluted $ (0.16) $ (0.72) Basic and diluted weighted average shares of common stock outstanding for the three months ended March 31, 2023 and March 31, 2022 include the weighted average effect of outstanding pre-funded warrants for the purchase of shares of common stock for which the remaining unfunded exercise price is $0.01 or less per share. During the three months ended March 31, 2022, in accordance with the Company’s Class B Warrant agreement, the exercise price of each outstanding Class B Warrant was adjusted to the price of shares of the Company’s common stock sold in public or private offerings to the extent such price is lower than the previous Class B warrant price. These price adjustments were accounted for as a deemed dividend that adjusts net loss available to common shareholders for purposes of basic earnings per share. The deemed dividend was calculated using the Black-Scholes pricing model, taking into account historical volatility of the Company’s common stock and the estimated remaining life of the outstanding Class B Warrants. The Class B Warrants expired in December 2022. The Company’s potentially dilutive securities include outstanding stock options, unvested restricted stock units and warrants to purchase shares of common stock for the three months ended March 31, 2023 and 2022. All potentially dilutive securities have been excluded from the computation of diluted net loss per share as the effect would be to reduce the net loss per share, and thus they are considered “anti-dilutive.” Therefore, the weighted average number of shares of common stock outstanding used to calculate both basic and diluted net loss per share attributable to common stockholders is the same. The Company excluded the following potential shares of common stock, presented based on amounts outstanding at each period end, from the computation of diluted net loss per share attributable to common stockholders for the periods indicated because including them would have had an anti-dilutive effect: Three Months Ended March 31, 2023 2022 Options to purchase shares of common stock 2,830,300 2,049,158 Unvested restricted stock units 5,835,016 1,940,788 Warrants to purchase shares of common stock (excluding prefunded warrants, which are included in basic shares outstanding) 87,720,773 9,449,028 96,386,089 13,438,974 |
Summary of Significant Accoun_2
Summary of Significant Accounting Policies (Policies) | 3 Months Ended |
Mar. 31, 2023 | |
Accounting Policies [Abstract] | |
Principles of Consolidation | Principles of Consolidation— The condensed consolidated financial statements include the accounts of the Company and its wholly-owned subsidiaries, including X4 Pharmaceuticals (Austria) GmbH, which is incorporated in Vienna, Austria (“X4 Austria”), and X4 Therapeutics, Inc. All significant intercompany accounts and transactions have been eliminated. |
Use of Estimates | Use of Estimates— The preparation of the Company’s consolidated financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities, the disclosure of contingent assets and liabilities at the date of the consolidated financial statements, and the reported amounts of expenses during the reporting period. Significant estimates and assumptions reflected in these consolidated financial statements include, but are not limited to, the accrual of research and development expenses, the impairment or lack of impairment of long-lived assets including operating lease right-of-use assets and goodwill, and assumptions underlying the fair value of warrant liabilities. The Company bases its estimates on historical experience, known trends and other market-specific or other relevant factors that it believes to be reasonable under the circumstances. On an ongoing basis, management evaluates its estimates when there are changes in circumstances, facts and experience. Changes in estimates are recorded in the period in which they become known. As of the date of issuance of these consolidated financial statements, the Company is not aware of any specific event or circumstance that would require the Company to update its estimates, assumptions and judgments or revise the carrying value of its assets or liabilities. Actual results could differ from those estimates, and any such differences may be material to the Company’s consolidated financial statements. |
Cash and Cash Equivalents | Cash and Cash Equivalents— The Company considers all highly liquid investments with maturities of three months or less at the date of purchase to be cash equivalents. Cash equivalents consisted of money market funds as of March 31, 2023 and December 31, 2022. |
Goodwill | Goodwill— Goodwill is tested for impairment at the reporting unit level annually in the fourth quarter, or more frequently when events or changes in circumstances indicate that the asset might be impaired. Examples of such events or circumstances include, but are not limited to, a significant adverse change in legal or business climate, an adverse regulatory action or unanticipated competition. The Company has determined that it operates in a single operating segment and has a single reporting unit. The Company assesses qualitative factors to determine whether the existence of events or circumstances would indicate that it is more likely than not that the fair value of the reporting unit is less than its carrying amount. If after assessing the totality of events or circumstances, the Company were to determine that it is more likely than not that the fair value of the reporting unit is less than its carrying amount, then the Company would perform an interim quantitative impairment test, whereby the Company compares the fair value of the reporting unit to its carrying value. If the fair value of the reporting unit exceeds the carrying value of its net assets, goodwill is not impaired, and no further testing is required. If the fair value of the reporting unit is less than its carrying value, the Company measures the amount of impairment loss, if any, as the excess of the carrying value over the fair value of the reporting unit . There were no triggering events during the three months ended March 31, 2023 that necessitated an interim impairment test of goodwill. |
Recently Adopted Accounting Pronouncements | Recently Adopted Accounting Standards In June 2016, the Financial Accounting Standards Board issued ASU 2016-13, Credit Losses (Topic 326) Measurement of Credit Losses on Financial Instruments |
Research and Development Expense, Policy |
Summary of Significant Accoun_3
Summary of Significant Accounting Policies (Tables) | 3 Months Ended |
Mar. 31, 2023 | |
Accounting Policies [Abstract] | |
Schedule of Restricted Cash | Restricted Cash (in thousands) As of March 31, 2023 As of December 31, 2022 Letter of credit security: Waltham lease $ 250 $ 250 Letter of credit security: Vienna Austria lease 206 205 Letter of credit security: Boston lease 571 855 Total restricted cash $ 1,027 $ 1,310 Restricted cash included in prepaid expenses and other current assets $ 250 $ 285 Restricted cash included in other assets $ 777 $ 1,025 |
Schedule of Reconciliation of Cash, Cash Equivalents, and Restricted Cash | The following table provides a reconciliation of cash, cash equivalents, and restricted cash reported within the condensed consolidated balance sheets to the sum of the total of amounts shown in the Company’s condensed consolidated statements of cash flows as of March 31, 2023 and December 31, 2022: (in thousands) March 31, 2023 December 31, 2022 Cash and cash equivalents $ 93,406 $ 121,718 Restricted cash, current portion 250 285 Restricted cash, non-current 777 1,025 Total cash, cash equivalents and restricted cash $ 94,433 $ 123,028 |
Fair Value of Financial Asset_2
Fair Value of Financial Assets and Liabilities (Tables) | 3 Months Ended |
Mar. 31, 2023 | |
Fair Value Disclosures [Abstract] | |
Schedule of Assets and Liabilities Measured at Fair Value | The following tables present information about the Company’s financial assets and liabilities measured at fair value on a recurring basis and indicate the level of the fair value hierarchy used to determine such fair values: Fair Value Measurements as of March 31, 2023 Using: (in thousands) Level 1 Level 2 Level 3 Total Assets: Cash equivalents—money market funds $ 70,959 $ 14 $ — $ 70,973 $ 70,959 $ 14 $ — $ 70,973 Liabilities: Embedded derivative liability $ — $ — $ 10 $ 10 Class C warrant liability — — 17,692 17,692 $ — $ — $ 17,702 $ 17,702 Fair Value Measurements as of December 31, 2022 Using: (in thousands) Level 1 Level 2 Level 3 Total Assets: Cash equivalents—money market funds $ 70,170 $ 2,858 $ — $ 73,028 $ 70,170 $ 2,858 $ — $ 73,028 Liabilities: Embedded derivative liability $ — $ — $ 10 $ 10 Class C warrant liability — — 23,131 23,131 $ — $ — $ 23,141 $ 23,141 |
Summary of Aggregate Fair Values of Warrant Liability and Derivative Liability | The following table provides a roll-forward of the aggregate fair values financial instruments for which fair values are determined using Level 3 inputs: (in thousands) Embedded Derivative Liability Class C Warrant Liability Total Balance as of December 31, 2022 $ 10 $ 23,131 $ 23,141 Change in fair value — (5,439) (5,439) Balance as of March 31, 2023 $ 10 $ 17,692 $ 17,702 |
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions | March 31, 2023 December 31, 2022 Common stock price $0.87 $0.99 Risk-free interest rate 3.9 % 4.0 % Expected term (in years) 4.7 years 4.9 years Expected volatility 91.9 % 101.7 % Expected dividend yield — % — % |
Property and Equipment, Net (Ta
Property and Equipment, Net (Tables) | 3 Months Ended |
Mar. 31, 2023 | |
Property, Plant and Equipment [Abstract] | |
Schedule of Property and Equipment | Property and equipment, net consisted of the following: (in thousands) March 31, 2023 December 31, 2022 Leasehold improvements $ 228 $ 228 Furniture and fixtures 1,274 1,268 Computer equipment 173 173 Software 24 24 Lab equipment 642 639 2,341 2,332 Less: Accumulated depreciation and amortization (1,355) (1,228) $ 986 $ 1,104 |
Accrued Expenses (Tables)
Accrued Expenses (Tables) | 3 Months Ended |
Mar. 31, 2023 | |
Payables and Accruals [Abstract] | |
Schedule of Accrued Expenses | Accrued expenses consisted of the following: (in thousands) March 31, December 31, Accrued employee compensation and benefits $ 2,742 6,592 Accrued external research and development expenses 7,721 3,906 Accrued professional fees 924 571 Accrued deferred financing fees — 591 Other 375 374 $ 11,762 $ 12,034 |
Long-Term Debt (Tables)
Long-Term Debt (Tables) | 3 Months Ended |
Mar. 31, 2023 | |
Debt Disclosure [Abstract] | |
Summary of Long Term Debt | Long-term debt consisted of the following: (in thousands) March 31, December 31, Principal amount of long-term debt $ 32,500 $ 32,500 Debt discount, net of accretion (767) (196) Cumulative accretion of end of term payments 648 1,315 Long-term debt $ 32,381 $ 33,619 Less: current portion $ (554) $ (1,315) Long-term debt, net of current portion $ 31,827 $ 32,304 |
Interest Income and Interest Expense Disclosure | The Company recognized interest expense under the Hercules Loan Agreement as follows: (in thousands) Three Months Ended March 31, 2023 2022 Total interest expense $ 884 $ 909 Non-cash interest expense $ 225 $ 198 |
Schedule of Future Principal Payments and the Final Payments Due | As of March 31, 2023, future principal and accrued end-of-term payments due under the Hercules Loan Agreement were as follows (in thousands): Year Ending December 31, Total 2023 $ 554 2024 4,750 2025 20,386 2026 7,458 Long-term debt $ 33,148 |
Leases (Tables)
Leases (Tables) | 3 Months Ended |
Mar. 31, 2023 | |
Leases [Abstract] | |
Schedule of Components of Lease Expense | The components of lease expense for the three months ended March 31, 2023 and 2022 were as follows: (dollars in thousands) Three Months Ended March 31, Lease Cost 2023 2022 Fixed operating lease cost $ 522 $ 530 Total lease expense $ 522 $ 530 Other information Operating cash flows from operating leases $ 346 $ 342 Sublease income $ 49 $ 49 Weighted-average remaining lease term—operating leases 3.8 years Weighted-average discount rate—operating leases 11.3 % |
Schedule of Maturities of Lease Liabilities | Maturities of lease liabilities due under lease agreements that have commenced as of March 31, 2023 are as follows (in thousands) Maturity of lease liabilities Operating 2023 (remainder of the year) $ 1,210 2024 1,378 2025 1,406 2026 1,337 2027 285 Thereafter 48 Total lease payments 5,664 Less: interest (1,112) Total operating lease liabilities as of March 31, 2023 $ 4,552 |
Common Stock Warrants (Tables)
Common Stock Warrants (Tables) | 3 Months Ended |
Mar. 31, 2023 | |
Equity [Abstract] | |
Schedule of Warrants | As of March 31, 2023, the Company’s outstanding warrants and pre-funded warrants to purchase shares of common stock consisted of the following: Issuance Date Number of Exercise Expiration Date October 25, 2016 5,155 $ 19.78 October 24, 2026 December 28, 2017 115,916 $ 19.78 December 28, 2027 September 12, 2018 20,220 $ 19.78 September 12, 2028 October 19, 2018 20,016 $ 19.78 October 19, 2028 March 13, 2019 5,000 $ 19.78 March 12, 2029 April 16, 2019 3,866,154 $ 13.20 April 15, 2024 November 29, 2019 1,250,000 $ 12.00 (a) n/a March 23, 2021 50,000 $ 8.70 (b) n/a November 9, 2021 2,008,032 $ 4.98 (c) n/a March 3, 2022 766,666 $ 1.80 (d) n/a July 6, 2022 13,276,279 $ 1.095 (e) n/a July 6, 2022 50,925,365 $ 1.095 July 6, 2027 December 9, 2022 32,762,947 $ 1.50 December 9, 2027 December 9, 2022 6,800,000 $ 1.10 (f) n/a 111,871,750 (a) In November 2019, the Company received $11.999 per pre-funded warrant, or $21.0 million in aggregate proceeds. Each pre-funded |
Stock-Based Compensation (Table
Stock-Based Compensation (Tables) | 3 Months Ended |
Mar. 31, 2023 | |
Share-Based Payment Arrangement [Abstract] | |
Stock Option Valuation | The following table presents, on a weighted average basis, the assumptions used in the Black-Scholes option-pricing model to determine the grant-date fair value of stock options granted to employees, directors and non-employees. Three Months Ended March 31, 2023 2022 Risk-free interest rate 3.6 % 2.0 % Expected term (in years) 6.0 6.1 Expected volatility 90.8 % 94.5 % Expected dividend yield 0 % 0 % |
Summary of Stock Option Activity | The following table summarizes the Company’s stock option activity for the three months ended March 31, 2023: Number of Weighted Weighted Aggregate Outstanding as of December 31, 2022 2,021,480 $ 6.99 6.5 $ 1 Granted 834,900 0.90 Forfeited and Expired (26,080) 8.68 Outstanding as of March 31, 2023 2,830,300 $ 5.18 8.0 $ — Exercisable as of March 31, 2023 1,163,500 $ 9.72 6.1 $ — Vested and expected to vest as of March 31, 2023 2,210,011 $ 6.20 7.6 $ — |
Share-based Payment Arrangement, Restricted Stock and Restricted Stock Unit, Activity | Restricted Stock Units— The following table summarizes the Company's restricted stock unit activity for the three months ended March 31, 2023: Number of Unvested as of December 31, 2022 1,680,563 Granted 4,694,691 Vested (540,238) Unvested as of March 31, 2023 5,835,016 |
Summary of Stock-Based Compensation Expense Classification | Stock-based compensation expense was classified in the condensed consolidated statements of operations as follows: Three Months Ended March 31, (in thousands) 2023 2022 Research and development expense $ 831 $ 704 Selling, general and administrative expense 814 755 Total stock-based compensation $ 1,645 $ 1,459 |
Share-Based Payment Arrangement, Option and Stock Appreciation Rights, Activity | The calculation of the fair value of the outstanding SARs as of March 31, 2023 includes the closing price of the Company’s common stock of $0.87 and the following assumptions on a weighted average basis: March 31, 2023 Risk free rate 3.6 % Expected term (years) 5.61 Expected volatility 90.8 % Expected dividend yield — % Expected forfeiture rate 22 % |
Net Loss per Share (Tables)
Net Loss per Share (Tables) | 3 Months Ended |
Mar. 31, 2023 | |
Earnings Per Share [Abstract] | |
Summary of Basic and Diluted Net Loss per Share Attributable to Common Stockholders | Basic and diluted net loss per share attributable to common stockholders was calculated as follow: Three Months Ended March 31, (in thousands, except per share data) 2023 2022 Numerator: Net loss $ (24,020) $ (21,965) Deemed dividend as a result of Class B warrant price reset — (2,259) Net loss attributable to common stockholders $ (24,020) $ (24,224) Denominator: Weighted average shares of common stock outstanding—basic and diluted 145,967 33,737 Net loss per share attributable to common stockholders— basic and diluted $ (0.16) $ (0.72) |
Schedule of Anti-dilutive Securities Excluded from Computation of Diluted Net Loss per Share Attributable to Common Stockholders | The Company excluded the following potential shares of common stock, presented based on amounts outstanding at each period end, from the computation of diluted net loss per share attributable to common stockholders for the periods indicated because including them would have had an anti-dilutive effect: Three Months Ended March 31, 2023 2022 Options to purchase shares of common stock 2,830,300 2,049,158 Unvested restricted stock units 5,835,016 1,940,788 Warrants to purchase shares of common stock (excluding prefunded warrants, which are included in basic shares outstanding) 87,720,773 9,449,028 96,386,089 13,438,974 |
Nature of the Business and Ba_2
Nature of the Business and Basis of Presentation - Additional Information (Detail) - USD ($) $ in Thousands | 3 Months Ended | ||
Mar. 31, 2023 | Mar. 31, 2022 | Dec. 31, 2022 | |
Business Acquisition [Line Items] | |||
Cash and cash equivalents | $ 93,406 | $ 121,718 | |
Accumulated deficit | (400,758) | $ (376,738) | |
Net cash used in operating activities | $ (26,512) | $ (20,229) |
Summary of Significant Accoun_4
Summary of Significant Accounting Policies - Schedule of Compensating Balance Arrangements (Detail) - USD ($) $ in Thousands | Mar. 31, 2023 | Dec. 31, 2022 |
Cash and Cash Equivalents [Line Items] | ||
Total restricted cash | $ 777 | $ 1,025 |
Restricted Cash | 1,027 | 1,310 |
Restricted cash, current portion | 250 | 285 |
Letter of Credit | Waltham Lease | ||
Cash and Cash Equivalents [Line Items] | ||
Restricted Cash | 250 | 250 |
Letter of Credit | Vienna Austria Lease | ||
Cash and Cash Equivalents [Line Items] | ||
Restricted Cash | 206 | 205 |
Letter of Credit | Allston Lease Agreement | ||
Cash and Cash Equivalents [Line Items] | ||
Restricted Cash | $ 571 | $ 855 |
Summary of Significant Accoun_5
Summary of Significant Accounting Policies - Schedule of Reconciliation of Cash, Cash Equivalents, and Restricted Cash (Detail) - USD ($) $ in Thousands | Mar. 31, 2023 | Dec. 31, 2022 | Mar. 31, 2022 | Dec. 31, 2021 |
Accounting Policies [Abstract] | ||||
Cash and cash equivalents | $ 93,406 | $ 121,718 | ||
Restricted cash, current portion | 250 | 285 | ||
Restricted cash, non-current | 777 | 1,025 | ||
Total cash, cash equivalents and restricted cash | $ 94,433 | $ 123,028 | $ 67,744 | $ 83,108 |
License, Collaboration, and F_2
License, Collaboration, and Funding Agreements - Additional Information (Detail) - USD ($) | 3 Months Ended | |
Mar. 31, 2023 | Mar. 31, 2022 | |
Collaboration License And Funding Arrangements [Line Items] | ||
Other income, net | $ 123,000 | $ 60,000 |
Gain (Loss) on Disposition of Other Assets | 500,000 | |
Research and Development Incentive | ||
Collaboration License And Funding Arrangements [Line Items] | ||
Grant receivable | 700,000 | |
Other income, net | $ 121,000 | $ 135,300 |
Fair Value of Financial Asset_3
Fair Value of Financial Assets and Liabilities - Schedule of Assets and Liabilities Measured at Fair Value (Detail) - Fair Value, Measurements, Recurring - USD ($) $ in Thousands | Mar. 31, 2023 | Dec. 31, 2022 |
Fair Value Assets And Liabilities Measured On Recurring Basis [Line Items] | ||
Cash equivalents | $ 70,973 | $ 73,028 |
Fair value of derivative liability | 17,702 | 23,141 |
Embedded derivative liability | ||
Fair Value Assets And Liabilities Measured On Recurring Basis [Line Items] | ||
Fair value of derivative liability | 10 | 10 |
Class C Warrant Liability | ||
Fair Value Assets And Liabilities Measured On Recurring Basis [Line Items] | ||
Fair value of derivative liability | 17,692 | 23,131 |
Level 1 | ||
Fair Value Assets And Liabilities Measured On Recurring Basis [Line Items] | ||
Cash equivalents | 70,959 | 70,170 |
Fair value of derivative liability | 0 | 0 |
Level 1 | Embedded derivative liability | ||
Fair Value Assets And Liabilities Measured On Recurring Basis [Line Items] | ||
Fair value of derivative liability | 0 | 0 |
Level 2 | ||
Fair Value Assets And Liabilities Measured On Recurring Basis [Line Items] | ||
Cash equivalents | 14 | 2,858 |
Fair value of derivative liability | 0 | 0 |
Level 2 | Embedded derivative liability | ||
Fair Value Assets And Liabilities Measured On Recurring Basis [Line Items] | ||
Fair value of derivative liability | 0 | 0 |
Level 3 | ||
Fair Value Assets And Liabilities Measured On Recurring Basis [Line Items] | ||
Cash equivalents | 0 | 0 |
Fair value of derivative liability | 17,702 | 23,141 |
Level 3 | Embedded derivative liability | ||
Fair Value Assets And Liabilities Measured On Recurring Basis [Line Items] | ||
Fair value of derivative liability | 10 | 10 |
Level 3 | Class C Warrant Liability | ||
Fair Value Assets And Liabilities Measured On Recurring Basis [Line Items] | ||
Fair value of derivative liability | $ 17,692 | $ 23,131 |
Fair Value of Financial Asset_4
Fair Value of Financial Assets and Liabilities - Aggregate Fair Values Financial Instruments (Details) $ in Thousands | 3 Months Ended |
Mar. 31, 2023 USD ($) | |
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward] | |
Beginning balance | $ 23,141 |
Change in fair value | (5,439) |
Ending balance | 17,702 |
Embedded Derivative Liability | |
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward] | |
Beginning balance | 10 |
Change in fair value | 0 |
Ending balance | 10 |
Class C Warrant Liability | |
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward] | |
Beginning balance | 23,131 |
Change in fair value | (5,439) |
Ending balance | $ 17,692 |
Fair Value of Financial Asset_5
Fair Value of Financial Assets and Liabilities - Narrative (Details) | Mar. 31, 2023 USD ($) |
Measurement Input, Discount Rate | |
Fair Value Assets And Liabilities Measured On Recurring Basis [Line Items] | |
Fair value of derivative liability | $ 0.14 |
Fair Value of Financial Asset_6
Fair Value of Financial Assets and Liabilities - Fair Value Assumptions (Details) - USD ($) $ / shares in Units, $ in Thousands | 3 Months Ended | |||
Mar. 31, 2023 | Dec. 31, 2022 | Mar. 31, 2023 | Mar. 31, 2022 | |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | ||||
Risk-free interest rate (in percentage) | 3.60% | 2% | ||
Expected term (in years) | 6 years | 6 years 1 month 6 days | ||
Expected volatility (in percentage) | 90.80% | 94.50% | ||
Expected dividend yield (in percentage) | 0% | 0% | ||
Fair value of warrant liability | $ 17,702 | $ 23,141 | $ 17,702 | |
Class C Warrant Liability | ||||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | ||||
Share Price (in dollars per share) | $ 0.87 | $ 0.99 | $ 0.87 | |
Risk-free interest rate (in percentage) | 3.90% | 4% | 3.60% | |
Expected term (in years) | 4 years 8 months 12 days | 4 years 10 months 24 days | 5 years 7 months 9 days | |
Expected volatility (in percentage) | 91.90% | 101.70% | 90.80% | |
Expected dividend yield (in percentage) | 0% | 0% | 0% |
Property and Equipment, Net - S
Property and Equipment, Net - Schedule of Property and Equipment, Net (Detail) - USD ($) $ in Thousands | Mar. 31, 2023 | Dec. 31, 2022 |
Property, Plant and Equipment [Line Items] | ||
Property and equipment, gross | $ 2,341 | $ 2,332 |
Less: Accumulated depreciation and amortization | (1,355) | (1,228) |
Property and equipment, net | 986 | 1,104 |
Leasehold improvements | ||
Property, Plant and Equipment [Line Items] | ||
Property and equipment, gross | 228 | 228 |
Furniture and fixtures | ||
Property, Plant and Equipment [Line Items] | ||
Property and equipment, gross | 1,274 | 1,268 |
Computer equipment | ||
Property, Plant and Equipment [Line Items] | ||
Property and equipment, gross | 173 | 173 |
Software | ||
Property, Plant and Equipment [Line Items] | ||
Property and equipment, gross | 24 | 24 |
Lab equipment | ||
Property, Plant and Equipment [Line Items] | ||
Property and equipment, gross | $ 642 | $ 639 |
Property and Equipment, Net - A
Property and Equipment, Net - Additional Information (Detail) - USD ($) $ in Thousands | 3 Months Ended | |
Mar. 31, 2023 | Mar. 31, 2022 | |
Property, Plant and Equipment [Abstract] | ||
Depreciation and amortization expense | $ 127 | $ 133 |
Accrued Expenses - Schedule of
Accrued Expenses - Schedule of Accrued Expenses (Detail) - USD ($) $ in Thousands | Mar. 31, 2023 | Dec. 31, 2022 |
Payables and Accruals [Abstract] | ||
Accrued employee compensation and benefits | $ 2,742 | $ 6,592 |
Accrued external research and development expenses | 7,721 | 3,906 |
Accrued professional fees | 924 | 571 |
Accrued deferred financing fees | 0 | 591 |
Other | 375 | 374 |
Total accrued expenses | $ 11,762 | $ 12,034 |
Long-Term Debt - Summary of Lon
Long-Term Debt - Summary of Long Term Debt (Detail) - USD ($) $ in Thousands | Mar. 31, 2023 | Dec. 31, 2022 |
Debt Disclosure [Abstract] | ||
Principal amount of long-term debt | $ 32,500 | $ 32,500 |
Debt discount, net of accretion | (767) | (196) |
Cumulative accretion of end of term payments | 648 | 1,315 |
Long-term debt | 32,381 | 33,619 |
Current portion of long-term debt | (554) | (1,315) |
Long-term debt, net of current portion | $ 31,827 | $ 32,304 |
Long Term Debt - Hercules Loan
Long Term Debt - Hercules Loan Agreement - Additional Information (Detail) - USD ($) | 3 Months Ended | 30 Months Ended | ||
Jul. 01, 2024 | Jul. 01, 2022 | Mar. 31, 2023 | Mar. 31, 2021 | |
Debt Instrument [Line Items] | ||||
Principal payments | $ 1,300,000 | |||
Hercules Loan Agreement | ||||
Debt Instrument [Line Items] | ||||
Proceeds from lines of credit | $ 32,500,000 | |||
Debt instrument variable percentage | 10.15% | |||
Interest rate increase percentage | 4% | |||
Line of credit facility periodic payment | $ 800,000 | |||
Effective interest rate of loan | 13.80% | |||
Principal payments | $ 0 | |||
Hercules Loan Agreement | Subsequent Event | ||||
Debt Instrument [Line Items] | ||||
Line of credit facility periodic payment | $ 1,300,000 | |||
Hercules Loan Agreement | Maximum | Period Two | ||||
Debt Instrument [Line Items] | ||||
Debt instrument prepayment premium, percentage | 3% | |||
Hercules Loan Agreement | Prime Rate | ||||
Debt Instrument [Line Items] | ||||
Debt instrument variable percentage | 3.15% | |||
Hercules Second Amended Loan Agreement | Min Cash Test Date 1 | ||||
Debt Instrument [Line Items] | ||||
Line of Credit, Covenant, Minimum Cash | $ 20,000,000 | |||
Hercules Second Amended Loan Agreement | Min Cash Test Date 2 | ||||
Debt Instrument [Line Items] | ||||
Line of Credit, Covenant, Minimum Cash | $ 10,000,000 |
Long-Term Debt - Summary of Int
Long-Term Debt - Summary of Interest Expense (Details) - Hercules Loan Agreement - USD ($) $ in Thousands | 3 Months Ended | |
Mar. 31, 2023 | Mar. 31, 2022 | |
Debt Instrument [Line Items] | ||
Interest expense, debt | $ 884 | $ 909 |
Amortization of debt discount | $ 225 | $ 198 |
Long-Term Debt - Schedule of Fu
Long-Term Debt - Schedule of Future Principal Payments and the Final Payments Due (Detail) $ in Thousands | Mar. 31, 2023 USD ($) |
Debt Disclosure [Abstract] | |
2023 | $ 554 |
2024 | 4,750 |
2024 | 20,386 |
2025 | 7,458 |
Principal amount of long-term debt | $ 33,148 |
Leases - Additional Information
Leases - Additional Information (Detail) $ in Thousands | 3 Months Ended | ||
Nov. 11, 2019 USD ($) ft² | Mar. 31, 2023 USD ($) ft² m² | Dec. 31, 2022 USD ($) | |
Lessee, Lease, Description [Line Items] | |||
Operating lease, liability | $ 4,552 | ||
Right-of-use assets | $ 6,844 | $ 7,229 | |
Waltham Lease | |||
Lessee, Lease, Description [Line Items] | |||
Current office space under lease agreement | ft² | 6,000 | ||
Current base rent | $ 300 | ||
Lease, term of contract (years) | 5 years | ||
Vienna Lease | |||
Lessee, Lease, Description [Line Items] | |||
Office space | m² | 1,200 | ||
Lease not yet commenced, term of contract | 7 years | ||
Annual base rent | $ 285 | ||
Allston Lease | |||
Lessee, Lease, Description [Line Items] | |||
Current office space under lease agreement | ft² | 28,000 | ||
Lease not yet commenced | $ 1,100 | ||
Lease, renewal term of contract (years) | 5 years |
Leases - Schedule of Components
Leases - Schedule of Components of Lease Expense (Detail) - USD ($) $ in Thousands | 3 Months Ended | |
Mar. 31, 2023 | Mar. 31, 2022 | |
Leases [Abstract] | ||
Fixed operating lease cost | $ 522 | $ 530 |
Total lease expense | 522 | 530 |
Operating cash flows from operating leases | 346 | 342 |
Sublease income | $ 49 | $ 49 |
Weighted-average remaining lease term-operating leases (in years) | 3 years 9 months 18 days | |
Weighted-average discount rate-operating leases | 11.30% |
Leases - Schedule of Maturities
Leases - Schedule of Maturities of Lease Liabilities (Detail) $ in Thousands | Mar. 31, 2023 USD ($) |
Leases [Abstract] | |
2020 | $ 1,210 |
2021 | 1,378 |
2022 | 1,406 |
2023 | 1,337 |
2024 | 285 |
2025 | 48 |
Total lease payments | 5,664 |
Less: interest | (1,112) |
Operating lease, liability | $ 4,552 |
Commitment and Contingencies -
Commitment and Contingencies - Additional Information (Detail) - USD ($) $ in Millions | Mar. 31, 2023 | Dec. 31, 2022 |
Indemnification Agreements | ||
Contingencies And Commitments [Line Items] | ||
Accrued liabilities | $ 0 | $ 0 |
Common Stock Warrants - Additio
Common Stock Warrants - Additional Information (Detail) - USD ($) | 3 Months Ended | ||||||
Mar. 31, 2023 | Dec. 31, 2022 | Jul. 06, 2022 | Mar. 03, 2022 | Mar. 23, 2021 | Nov. 02, 2020 | Nov. 29, 2019 | |
Class of Warrant or Right [Line Items] | |||||||
Common stock, shares authorized | 500,000,000 | 500,000,000 | |||||
Common stock, par value (in usd per share) | $ 0.001 | $ 0.001 | |||||
Dividends on common stock declared or paid | $ 0 | ||||||
Class of Warrant or Right, Additional Exercise Price of Warrants or Rights | $ 0.001 | $ 0.01 | $ 0.01 | $ 0.001 | |||
Q1 2022 Private Placement | |||||||
Class of Warrant or Right [Line Items] | |||||||
Class of Warrant or Right, Additional Exercise Price of Warrants or Rights | $ 0.01 |
Common Stock Warrants - Summary
Common Stock Warrants - Summary of Outstanding Warrants to Purchase Shares of Common Stock (Detail) - USD ($) $ / shares in Units, $ in Thousands | Mar. 31, 2023 | Dec. 09, 2022 | Jul. 06, 2022 | Mar. 03, 2022 | Nov. 09, 2021 | Mar. 23, 2021 | Nov. 02, 2020 | Nov. 29, 2019 |
Class of Warrant or Right [Line Items] | ||||||||
Number of Shares of Common Stock Issuable (in shares) | 111,871,750 | |||||||
Class Of Warrant Or Right. Aggregate Proceeds From Warrants Issued | $ 7,500 | $ 14,500 | $ 1,400 | $ 10,000 | $ 435 | $ 21,000 | ||
Class of Warrant or Right, Additional Exercise Price of Warrants or Rights | $ 0.001 | $ 0.01 | $ 0.01 | $ 0.001 | ||||
Funded | ||||||||
Class of Warrant or Right [Line Items] | ||||||||
Exercise Price (usd per share) | $ 1.094 | $ 1.79 | $ 4.97 | $ 8.69 | $ 11.999 | |||
Issuance On October 25, 2016 | ||||||||
Class of Warrant or Right [Line Items] | ||||||||
Exercise Price (usd per share) | $ 19.78 | |||||||
Issuance On October 25, 2016 | Legacy Warrants | ||||||||
Class of Warrant or Right [Line Items] | ||||||||
Number of Shares of Common Stock Issuable (in shares) | 5,155 | |||||||
Issuance On December 28, 2017 One | ||||||||
Class of Warrant or Right [Line Items] | ||||||||
Exercise Price (usd per share) | $ 19.78 | |||||||
Issuance On December 28, 2017 One | Legacy Warrants | ||||||||
Class of Warrant or Right [Line Items] | ||||||||
Number of Shares of Common Stock Issuable (in shares) | 115,916 | |||||||
Issuance On September 12, 2018 One | ||||||||
Class of Warrant or Right [Line Items] | ||||||||
Exercise Price (usd per share) | $ 19.78 | |||||||
Issuance On September 12, 2018 One | Legacy Warrants | ||||||||
Class of Warrant or Right [Line Items] | ||||||||
Number of Shares of Common Stock Issuable (in shares) | 20,220 | |||||||
Issuance On October 19, 2018 | ||||||||
Class of Warrant or Right [Line Items] | ||||||||
Exercise Price (usd per share) | $ 19.78 | |||||||
Issuance On October 19, 2018 | Legacy Warrants | ||||||||
Class of Warrant or Right [Line Items] | ||||||||
Number of Shares of Common Stock Issuable (in shares) | 20,016 | |||||||
Issuance On March 13, 2019 | ||||||||
Class of Warrant or Right [Line Items] | ||||||||
Exercise Price (usd per share) | $ 19.78 | |||||||
Issuance On March 13, 2019 | Legacy Warrants | ||||||||
Class of Warrant or Right [Line Items] | ||||||||
Number of Shares of Common Stock Issuable (in shares) | 5,000 | |||||||
Issuance On April 16, 2019 | ||||||||
Class of Warrant or Right [Line Items] | ||||||||
Exercise Price (usd per share) | $ 13.20 | |||||||
Issuance On April 16, 2019 | Class A Warrant | ||||||||
Class of Warrant or Right [Line Items] | ||||||||
Number of Shares of Common Stock Issuable (in shares) | 3,866,154 | |||||||
Issuance On November 29, 2019 One | ||||||||
Class of Warrant or Right [Line Items] | ||||||||
Exercise Price (usd per share) | $ 12 | |||||||
Issuance On November 29, 2019 One | Pre Funded Warrant | ||||||||
Class of Warrant or Right [Line Items] | ||||||||
Number of Shares of Common Stock Issuable (in shares) | 1,250,000 | |||||||
Issuance On March 23, 2021 | ||||||||
Class of Warrant or Right [Line Items] | ||||||||
Exercise Price (usd per share) | $ 8.70 | |||||||
Issuance On March 23, 2021 | Pre Funded Warrant | ||||||||
Class of Warrant or Right [Line Items] | ||||||||
Number of Shares of Common Stock Issuable (in shares) | 50,000 | |||||||
Issuance on November Nine Two Thousand Twenty One | ||||||||
Class of Warrant or Right [Line Items] | ||||||||
Number of Shares of Common Stock Issuable (in shares) | 2,008,032 | |||||||
Exercise Price (usd per share) | $ 4.98 | |||||||
Issuance on March 3 2022 | ||||||||
Class of Warrant or Right [Line Items] | ||||||||
Number of Shares of Common Stock Issuable (in shares) | 766,666 | |||||||
Exercise Price (usd per share) | $ 1.80 | |||||||
Issuance on July 2022 1 | ||||||||
Class of Warrant or Right [Line Items] | ||||||||
Number of Shares of Common Stock Issuable (in shares) | 13,276,279 | |||||||
Exercise Price (usd per share) | $ 1.095 | |||||||
Issuance on July 6 2022 Two | ||||||||
Class of Warrant or Right [Line Items] | ||||||||
Number of Shares of Common Stock Issuable (in shares) | 50,925,365 | |||||||
Exercise Price (usd per share) | $ 1.095 | |||||||
Issuance on December 9 2022 | ||||||||
Class of Warrant or Right [Line Items] | ||||||||
Number of Shares of Common Stock Issuable (in shares) | 32,762,947 | |||||||
Exercise Price (usd per share) | $ 1.50 | |||||||
Issuance on December 9 2022 2 | ||||||||
Class of Warrant or Right [Line Items] | ||||||||
Number of Shares of Common Stock Issuable (in shares) | 6,800,000 | |||||||
Exercise Price (usd per share) | $ 1.10 |
Stock-Based Compensation - Addi
Stock-Based Compensation - Additional Information (Detail) - USD ($) $ / shares in Units, $ in Thousands | 3 Months Ended | |
Mar. 31, 2023 | Mar. 31, 2022 | |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | ||
Options granted, weighted average grant date fair value (in usd per share) | $ 0.69 | $ 1.42 |
Restricted Stock Units (RSUs) | ||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | ||
Unrecognized compensation cost of stock based awards | $ 6,200 | |
Unrecognized compensation cost of stock based awards, recognition period | 1 year 3 months 18 days | |
2019 Equity Incentive Plan | ||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | ||
Shares reserved for issuance | 1,000,000 | |
Two Thousand Seventeen Equity Incentive Plan | ||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | ||
Shares reserved for issuance | 150,000 |
Stock-Based Compensation - Sche
Stock-Based Compensation - Schedule of Assumptions Used in Black-Scholes Option-Pricing Model to Determine Grant-date Fair Value of Stock Options Granted (Detail) | 3 Months Ended | |||
Mar. 31, 2023 | Dec. 31, 2022 | Mar. 31, 2023 | Mar. 31, 2022 | |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | ||||
Risk-free interest rate (in percentage) | 3.60% | 2% | ||
Expected term (in years) | 6 years | 6 years 1 month 6 days | ||
Expected volatility (in percentage) | 90.80% | 94.50% | ||
Expected dividend yield (in percentage) | 0% | 0% | ||
Class C Warrant Liability | ||||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | ||||
Risk-free interest rate (in percentage) | 3.90% | 4% | 3.60% | |
Expected term (in years) | 4 years 8 months 12 days | 4 years 10 months 24 days | 5 years 7 months 9 days | |
Expected volatility (in percentage) | 91.90% | 101.70% | 90.80% | |
Expected dividend yield (in percentage) | 0% | 0% | 0% | |
Expected forfeiture rate (in percentage) | 22% |
Stock-Based Compensation - Summ
Stock-Based Compensation - Summary of Stock Option Activity (Detail) - USD ($) $ / shares in Units, $ in Thousands | 3 Months Ended | 6 Months Ended |
Mar. 31, 2023 | Jun. 30, 2022 | |
Number of Shares | ||
Beginning balance (in shares) | 2,021,480 | |
Granted (in shares) | 834,900 | |
Forfeited (in shares) | (26,080) | |
Ending balance (in shares) | 2,830,300 | |
Number of shares Options, Exercisable (in shares) | 1,163,500 | |
Number of shares Options, Vested and expected to vest (in shares) | 2,210,011 | |
Weighted Average Exercise Price | ||
Beginning balance (in usd per share) | $ 6.99 | |
Granted (in usd per share) | 0.90 | |
Forfeited (in usd per share) | 8.68 | |
Ending balance (in usd per share) | 5.18 | |
Weighted average exercise price, Exercisable (in usd per share) | 9.72 | |
Weighted average exercise price, Vested and expected to vest (in usd per share) | $ 6.20 | |
Weighted average contractual term outstanding (in years) | 8 years | 6 years 6 months |
Weighted average contractual term outstanding, Exercisable (in years) | 6 years 1 month 6 days | |
Weighted average contractual term outstanding, Vested and expected to vest (in years) | 7 years 7 months 6 days | |
Aggregate intrinsic value, Beginning balance | $ 1 | |
Aggregate intrinsic value, Ending balance | 0 | |
Aggregate intrinsic value, exercisable | 0 | |
Aggregate intrinsic value, vested and expected to vest | $ 0 |
Stock-Based Compensation (Detai
Stock-Based Compensation (Details) | 3 Months Ended |
Mar. 31, 2023 shares | |
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward] | |
Granted (in shares) | 4,694,691 |
Vested (in shares) | (540,238) |
Nonvested ending balance (in shares) | 5,835,016 |
Restricted Stock Units (RSUs) | |
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward] | |
Nonvested beginning balance (in shares) | 1,680,563 |
Stock-Based Compensation Summar
Stock-Based Compensation Summary of Stock-Based Compensation Expense Classification (Details) - USD ($) $ in Thousands | 3 Months Ended | |
Mar. 31, 2023 | Mar. 31, 2022 | |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | ||
Total stock-based compensation | $ 1,645 | $ 1,459 |
Research and development expense | ||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | ||
Total stock-based compensation | 831 | 704 |
Selling, general and administrative expense | ||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | ||
Total stock-based compensation | $ 814 | $ 755 |
Income Taxes - Additional Infor
Income Taxes - Additional Information (Detail) - USD ($) $ in Thousands | 3 Months Ended | |
Mar. 31, 2023 | Mar. 31, 2022 | |
Income Tax Disclosure [Abstract] | ||
Federal income tax benefit | $ 0 | $ 0 |
State income tax benefit | 0 | 0 |
Provision for income taxes | $ 4 | $ 23 |
Net Loss per Share - Summary of
Net Loss per Share - Summary of Basic and Diluted Net loss per Share Attributable to Common Stockholders (Detail) - USD ($) $ / shares in Units, $ in Thousands | 3 Months Ended | |
Mar. 31, 2023 | Mar. 31, 2022 | |
Numerator: | ||
Net loss | $ (24,020) | $ (21,965) |
Dividends, Paid-in-kind | 0 | (2,259) |
Net loss attributable to common stockholders | $ (24,020) | $ (24,224) |
Denominator: | ||
Weighted average shares of common stock outstanding—basic | 145,967,000 | 33,737,000 |
Weighted average shares of common stock outstanding—diluted | 145,967,000 | 33,737,000 |
Net loss per share attributable to common stockholders—basic | $ (0.16) | $ (0.72) |
Net loss per share attributable to common stockholders—diluted | $ (0.16) | $ (0.72) |
Net Loss per Share - Additional
Net Loss per Share - Additional Information (Detail) | Mar. 31, 2023 $ / shares |
Pre Funded Warrant | Maximum | |
Earnings Per Share, Basic, by Common Class, Including Two Class Method [Line Items] | |
Exercise Price (usd per share) | $ 0.01 |
Net Loss per Share - Schedule o
Net Loss per Share - Schedule of Anti-dilutive Securities Excluded from Computation of Diluted Net Loss per Share Attributable to Common Stockholders (Detail) - shares | 3 Months Ended | |
Mar. 31, 2023 | Mar. 31, 2022 | |
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] | ||
Anti-dilutive securities excluded from computation of diluted net loss per share (in shares) | 96,386,089 | 13,438,974 |
Employee Stock Option | ||
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] | ||
Anti-dilutive securities excluded from computation of diluted net loss per share (in shares) | 2,830,300 | 2,049,158 |
Restricted Stock Units (RSUs) | ||
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] | ||
Anti-dilutive securities excluded from computation of diluted net loss per share (in shares) | 5,835,016 | 1,940,788 |
Class C Warrant Liability | ||
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] | ||
Anti-dilutive securities excluded from computation of diluted net loss per share (in shares) | 87,720,773 | 9,449,028 |