Document and Entity Information
Document and Entity Information - shares | 3 Months Ended | |
Mar. 31, 2018 | Apr. 30, 2018 | |
Document And Entity Information [Abstract] | ||
Document Type | 10-Q | |
Amendment Flag | false | |
Document Period End Date | Mar. 31, 2018 | |
Document Fiscal Year Focus | 2,018 | |
Document Fiscal Period Focus | Q1 | |
Trading Symbol | ADVM | |
Entity Registrant Name | Adverum Biotechnologies, Inc. | |
Entity Central Index Key | 1,501,756 | |
Current Fiscal Year End Date | --12-31 | |
Entity Filer Category | Accelerated Filer | |
Entity Common Stock, Shares Outstanding | 62,271,901 |
Condensed Consolidated Balance
Condensed Consolidated Balance Sheets (Unaudited) - USD ($) $ in Thousands | Mar. 31, 2018 | Dec. 31, 2017 |
Current assets: | ||
Cash and cash equivalents | $ 152,716 | $ 70,519 |
Short-term investments | 94,321 | 119,966 |
Prepaid expenses and other current assets | 2,161 | 3,256 |
Total current assets | 249,198 | 193,741 |
Property and equipment, net | 2,820 | 3,024 |
Deposit and other long-term assets | 140 | 140 |
Intangible asset | 5,000 | 5,000 |
Total assets | 257,158 | 201,905 |
Current liabilities: | ||
Accounts payable | 685 | 1,731 |
Accrued expenses and other current liabilities | 7,205 | 6,964 |
Deferred rent, current portion | 138 | 129 |
Deferred revenue, current portion | 1,246 | 1,850 |
Total current liabilities | 9,274 | 10,674 |
Deferred rent, net of current portion | 187 | 222 |
Deferred revenue, net of current portion | 5,250 | |
Deferred tax liability | 1,250 | 1,250 |
Other noncurrent liabilities | 404 | 481 |
Total liabilities | 11,115 | 17,877 |
Commitments and contingencies (Note 6) | ||
Stockholders’ equity: | ||
Preferred stock, $0.0001 par value, 5,000,000 shares authorized; no shares issued and outstanding | ||
Common stock, $0.0001 par value, 300,000,000 shares authorized at March 31, 2018 and December 31, 2017; 62,232,372 and 49,015,339 shares issued and outstanding at March 31, 2018 and December 31, 2017, respectively | 7 | 5 |
Additional paid-in capital | 512,173 | 439,048 |
Accumulated other comprehensive loss | (1,021) | (963) |
Accumulated deficit | (265,116) | (254,062) |
Total stockholders’ equity | 246,043 | 184,028 |
Total liabilities and stockholders' equity | $ 257,158 | $ 201,905 |
Condensed Consolidated Balance3
Condensed Consolidated Balance Sheets (Parenthetical) (Unaudited) - $ / shares | Mar. 31, 2018 | Dec. 31, 2017 |
Statement Of Financial Position [Abstract] | ||
Preferred stock, par value | $ 0.0001 | $ 0.0001 |
Preferred stock, shares authorized | 5,000,000 | 5,000,000 |
Preferred stock, shares issued | 0 | 0 |
Preferred stock, shares outstanding | 0 | 0 |
Common stock, par value | $ 0.0001 | $ 0.0001 |
Common stock, shares authorized | 300,000,000 | 300,000,000 |
Common stock, shares issued | 62,232,372 | 49,015,339 |
Common stock, shares outstanding | 62,232,372 | 49,015,339 |
Condensed Consolidated Statemen
Condensed Consolidated Statements of Operations and Comprehensive Loss (Unaudited) - USD ($) shares in Thousands, $ in Thousands | 3 Months Ended | |
Mar. 31, 2018 | Mar. 31, 2017 | |
Income Statement [Abstract] | ||
Collaboration and license revenue | $ 216 | $ 462 |
Operating expenses: | ||
Research and development | 12,794 | 9,061 |
General and administrative | 5,368 | 7,989 |
Total operating expenses | 18,162 | 17,050 |
Operating loss | (17,946) | (16,588) |
Other income: | ||
Other income, net | 746 | 489 |
Total other income, net | 746 | 489 |
Net loss | (17,200) | (16,099) |
Other comprehensive loss: | ||
Net unrealized (loss) gain on marketable securities | 17 | (88) |
Foreign currency translation adjustment | (75) | (118) |
Comprehensive loss | $ (17,258) | $ (16,305) |
Net loss per share attributable to common stockholders-basic and diluted | $ (0.30) | $ (0.38) |
Weighted-average common shares outstanding-basic and diluted | 57,420 | 42,144 |
Condensed Consolidated Stateme5
Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($) $ in Thousands | 3 Months Ended | |
Mar. 31, 2018 | Mar. 31, 2017 | |
Cash flows from operating activities: | ||
Net loss | $ (17,200) | $ (16,099) |
Adjustments to reconcile net loss to net cash used in operating activities: | ||
Depreciation and amortization | 459 | 516 |
Stock-based compensation expense | 3,429 | 1,896 |
Other | 183 | 89 |
Changes in operating assets and liabilities: | ||
Accounts receivable, net | 886 | |
Prepaid expenses and other current assets | 818 | (462) |
Accounts payable | (1,046) | 1,610 |
Accrued expenses and other current liabilities | 107 | 229 |
Deferred revenue | 292 | (462) |
Deferred rent | (26) | (20) |
Net cash used in operating activities | (12,984) | (11,817) |
Cash flows from investing activities: | ||
Purchases of marketable securities | (30,374) | (138,591) |
Maturities of marketable securities | 55,973 | |
Purchases of property and equipment | (216) | (263) |
Net cash provided by (used in) investing activities | 25,383 | (138,854) |
Cash flows from financing activities: | ||
Proceeds from offerings of common stock, net of issuance costs | 70,191 | |
Proceeds from issuance of common stock pursuant to option exercises | 308 | 187 |
Taxes paid related to net share settlement of restricted stock units | (801) | |
Proceeds from a financing arrangement | 100 | |
Net cash provided by financing activities | 69,798 | 187 |
Effect of foreign currency exchange rate on cash and cash equivalents | (117) | |
Net increase (decrease) in cash and cash equivalents | 82,197 | (150,601) |
Cash and cash equivalents at beginning of period | 70,519 | 222,170 |
Cash and cash equivalents at end of period | 152,716 | 71,569 |
Supplemental schedule of noncash investing and financing information | ||
Fixed assets in accounts payable, accrued expenses and other current liabilities | $ 153 | $ 413 |
Organization and Basis of Prese
Organization and Basis of Presentation | 3 Months Ended |
Mar. 31, 2018 | |
Accounting Policies [Abstract] | |
Organization and Basis of Presentation | 1. Organization and Basis of Presentation Adverum Biotechnologies, Inc. (the “Company”) was incorporated in Delaware on July 17, 2006 as Avalanche Biotechnologies, Inc. and changed its name to Adverum Biotechnologies, Inc. on May 11, 2016. The Company is headquartered in Menlo Park, California. The Company is a gene therapy company advancing novel medicines that has the potential to offer life-changing benefits to patients living with serious rare and ocular diseases. Since the Company’s inception, it has devoted its efforts principally to performing research and development activities, including conducting preclinical studies and, early clinical trials, filing patent applications, obtaining regulatory agreements, hiring personnel, and raising capital to support these activities. The Company has not generated any revenue from the sale of products since its inception. The Company has experienced net losses since its inception and had an accumulated deficit of $265.1 million as of March 31, 2018. The Company expects to incur losses and have negative net cash flows from operating activities as it engages in further research and development activities. The Company believes that it has sufficient funds to continue operations through at least the end of 2019. Follow-on Offerings — In February 2018, the Company completed an underwritten public offering for the sale of 10,222,235 shares of its common stock and raised total net proceeds of $64.5 million, after discounts and other issuance costs. In August 2017, the Company entered into an at-the-market sales agreement with an agent for the sales of its common stock at market price (the “2017 stock offering agreement”). In January 2018, the Company issued and sold a total of 1,419,893 shares of its common stock at market prices under the 2017 stock offering agreement and raised total net proceeds of $5.7 million, after issuance costs. Basis of Presentation —The accompanying unaudited condensed consolidated financial statements have been prepared in accordance with U.S. generally accepted accounting principles (“U.S. GAAP”) and follow the requirements of the Securities and Exchange Commission (“SEC”) for interim reporting. As permitted under those rules, certain footnotes or other financial information that are normally required by U.S. GAAP can be condensed or omitted. These unaudited condensed consolidated financial statements have been prepared on the same basis as the Company’s annual consolidated financial statements and, in the opinion of management, reflect all adjustments, consisting only of normal recurring adjustments, which are necessary for a fair statement of the Company’s consolidated financial information. The results of operations for the three months ended March 31, 2018, are not necessarily indicative of the results to be expected for the full year or any other future period. The balance sheet as of December 31, 2017 is derived from the audited consolidated financial statements at that date but does not include all of the information required by U.S. GAAP for complete consolidated financial statements. The accompanying unaudited condensed consolidated financial statements and related financial information should be read in conjunction with the audited consolidated financial statements and the related notes thereto included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2017 filed with the SEC. |
Summary of Significant Accounti
Summary of Significant Accounting Policies | 3 Months Ended |
Mar. 31, 2018 | |
Accounting Policies [Abstract] | |
Summary of Significant Accounting Policies | 2. Summary of Significant Accounting Policies Use of Estimates — The accompanying consolidated financial statements have been prepared in accordance with U.S. GAAP. The preparation of the consolidated financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities, disclosure of contingent liabilities and the reported amounts of expenses in the consolidated financial statements and the accompanying notes. On an ongoing basis, management evaluates its estimates, including those related to clinical trial accruals, fair value of assets and liabilities, income taxes, and stock-based compensation. Management bases its estimates on historical experience and on various other market-specific and relevant assumptions that management believes to be reasonable under the circumstances. Actual results could differ from those estimates. Accounting Standard Updates Recently Adopted Accounting Standard Update (“ASU”) No. 2014-09, Revenue from Contracts with Customers (Topic 606), which supersedes the revenue recognition requirements in ASC 605, Revenue Recognition . Effective January 1, 2018, the Company adopted the new revenue standards under Topic 606 using the modified retrospective approach. Results for reporting periods beginning after January 1, 2018 are presented under Topic 606, while prior period results are not adjusted and continue to be reported in accordance with the revenue standards under Topic 605. Under ASC 606, the Company recognizes revenue when its customer obtains control of promised goods or services, in an amount that reflects the consideration which the Company expects to receive in exchange for those goods or services. To determine revenue recognition for arrangements that the Company determines are within the scope of ASC 606, the Company performs the following five steps: (i) identify the contract(s) with a customer; (ii) identify the performance obligations in the contract; (iii) determine the transaction price; (iv) allocate the transaction price to the performance obligations in the contract; and (v) recognize revenue when (or as) the Company satisfies a performance obligation. At contract inception, once the contract is determined to be within the scope of ASC 606, the Company assesses the goods or services promised within each contract and determines those that are performance obligations. The Company then recognizes as revenue the amount of the transaction price that is allocated to the respective performance obligation when (or as) the performance obligation is satisfied. The Company’s license and collaboration arrangements with Regeneron Pharmaceuticals, Inc. (“Regeneron”) and Editas Medicine, Inc. (“Editas”) are within the scope of Topic 606. Upon the adoption of Topic 606, the Company recorded a net decrease of $6.1 million to its deferred revenue and opening accumulated deficit as of January 1, 2018 for the cumulative effect of the adoption. The effect of the adoption is summarized for the Company’s license and collaboration agreements as follows: Collaboration Agreement with Regeneron — Under Topic 606, the transaction price at contract inception is $8.0 million related to the non-refundable upfront payment for license and research services. The arrangement also provides for additional payments to the Company when certain development and regulatory milestones are achieved. Since these milestone payments are not within the control of the Company and are not considered probable of being achieved until the events occur, the Company did not include them in the transaction price at contract inception. The transaction price of $8.0 million at contract inception was allocated to two performance obligations. The Company’s deferred revenue associated with its Regeneron collaboration agreement as of December 31, 2017 under Topic 605 was $6.5 million. As a result of adopting Topic 606, the Company recorded $6.5 million reduction to its deferred revenue and opening accumulated deficit during the three months ended March 31, 2018 as the performance obligations associated with the Regeneron deferred revenue were satisfied as of January 1, 2018. There was no outstanding deferred revenue associated with Regeneron as of March 31, 2018. Collaboration Agreement with Editas — Under Topic 606, the transaction price at contract inception is $1.0 million related to the non-refundable upfront payment for license and research services. The arrangement provides for additional payments to the Company when certain development and regulatory milestones are achieved. Since these milestone payments are not within the control of the Company and are not considered probable of being achieved until the events occur, the Company did not include them in the transaction price at contract inception. The transaction price of $1.0 million was allocated to a single performance obligation. The Company’s deferred revenue associated with its Editas collaboration agreement as of December 31, 2017 under Topic 605 was $0.5 million. As a result of adopting Topic 606, the Company recorded an increase of $0.4 million to its deferred revenue and opening accumulated deficit during the three months ended March 31, 2018 due to differences in the timing of recognition under Topic 606. Under Topic 605, the Company’s revenue for the three months March 31, 2018 would have been $0.5 million. Recently-Issued and Not Yet Adopted Accounting Pronouncements In February 2016, the Financial Accounting Standards Board (“FASB”) issued ASU No. 2016-2, Leases, which amends the current guidance on leasing activities to provide more transparency and comparability, and requires that all leases be recognized by lessees on their balance sheet as a right-of-use asset and corresponding lease liability, which are currently accounted for as operating leases. The new standard is effective for fiscal years and interim periods within those fiscal years beginning after December 15, 2018, with early adoption permitted. This ASU will be effective for the Company in the first quarter of 2019 and must be adopted using a modified retrospective transition approach. The Company is currently evaluating the impact of the adoption of this standard on its consolidated financial statements and related disclosures. |
Fair Value Measurements and Fai
Fair Value Measurements and Fair Value of Financial Instruments | 3 Months Ended |
Mar. 31, 2018 | |
Fair Value Disclosures [Abstract] | |
Fair Value Measurements and Fair Value of Financial Instruments | 3. Fair Value Measurements and Fair Value of Financial Instruments The authoritative guidance on the fair value hierarchy for disclosure of fair value measurements is as follows: Level 1 : Quoted prices in active markets for identical assets or liabilities. Level 2 : Observable inputs other than Level 1 prices, such as quoted prices for similar assets or liabilities, quoted prices in markets that are not active, or other inputs that are observable or can be corroborated by observable market data for substantially the full term of the assets or liabilities. Level 3 : Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities. The fair value of Level 1 securities is determined using quoted prices in active markets for identical assets. Level 1 securities consist of highly liquid money market funds. Financial assets and liabilities are considered Level 2 when their fair values are determined using inputs that are observable in the market or can be derived principally from or corroborated by observable market data such as pricing for similar securities, recently executed transactions, cash flow models with yield curves, and benchmark securities. In addition, Level 2 financial instruments are valued using comparisons to like-kind financial instruments and models that use readily observable market data as their basis. U.S. government and agency securities, commercial paper, corporate bond and certificates of deposit are valued primarily using market prices of comparable securities, bid/ask quotes, interest rate yields and prepayment spreads and are included in Level 2. In certain cases where there is limited activity or less transparency around inputs to valuation, securities are classified as Level 3 within the valuation hierarchy. The following is a summary of the Company’s cash equivalents and short-term investments as of March 31, 2018: March 31, 2018 Amortized Cost Basis Unrealized Gains Unrealized Loses Estimated Fair Value (In thousands) Level 1: Money market funds $ 59 $ — $ — $ 59 Level 2: U.S. government and agency securities 38,278 — (135 ) 38,143 Commercial paper 159,844 — — 159,844 Corporate bonds 32,797 — (30 ) 32,767 Certificates of deposit 7,836 — — 7,836 Total cash equivalents and short-term investments 238,814 — (165 ) 238,649 Less: cash equivalents (144,329 ) — 1 (144,328 ) Total short-term investments $ 94,485 $ — $ (164 ) $ 94,321 The following is a summary of the Company’s cash equivalents and short-term investments as of December 31, 2017: December 31, 2017 Amortized Cost Basis Unrealized Gains Unrealized Loses Estimated Fair Value (In thousands) Level 1: Money market funds $ 65 $ — $ — $ 65 Level 2: U.S. government and agency securities 58,351 — (145 ) 58,206 Commercial paper 71,427 — — 71,427 Corporate bonds 38,354 1 (38 ) 38,317 Certificates of deposit 9,731 — — 9,731 Total cash equivalents and short-term investments 177,928 1 (183 ) 177,746 Less: cash equivalents (57,780 ) — — (57,780 ) Total short-term investments $ 120,148 $ 1 $ (183 ) $ 119,966 As of March 31, 2018 and December 31, 2017, the fair value of the Company’s financing liability related to The Alpha-1 Project, Inc. (the “TAP financing”), which is classified within Level 3 in the fair value hierarchy, was $0.2 million. The Company elected the fair value option to account for this financing arrangement. The fair value of the financing arrangement was determined based on the expected value approach and is classified as Level 3 within the fair value hierarchy. The key unobservable inputs in the valuation model include timing of milestones, probability of achievement of development and commercial milestones, and a discount factor. There were no transfers within the hierarchy during the three months ended March 31, 2018. The Company’s marketable securities as of March 31, 2018 mature within one year. Management regularly reviews all of the Company’s investments for other-than-temporary declines in estimated fair value. Management’s review includes the consideration of the cause of the impairment, including the creditworthiness of the security issuers, the number of securities in an unrealized loss position, the severity and duration of the unrealized losses, whether management has the intent to sell the securities and whether it is more likely than not that the Company will be required to sell the securities before the recovery of their amortized cost basis. Management determined that the gross unrealized losses of $0.2 million on the Company’s marketable securities as of March 31, 2018 were temporary in nature. Therefore, none of the Company’s marketable securities were other-than-temporarily impaired as of March 31, 2018. |
Significant Agreements
Significant Agreements | 3 Months Ended |
Mar. 31, 2018 | |
Research And Development [Abstract] | |
Significant Agreements | 4. Significant Agreements Editas— In January 2018, the Company entered into an agreement to amend its collaboration, option and license agreement with Editas. The Company originally entered into an agreement with Editas in August 2016 pursuant to which the Company and Editas collaborate on certain studies using AAV vectors in connection with Editas’ genome editing technology and the Company grants to Editas an exclusive option to obtain certain exclusive rights to use the Company’s proprietary vectors in up to five ophthalmic indications. In January 2018, the Company and Editas extended the research collaboration, option and license agreement. In consideration for extending the agreement, Editas made a one-time, non-refundable cash payment of $0.5 million to the Company in February 2018. Under the terms of the agreement, as amended, Editas may exercise the option with respect to a designated initial indication until September 30, 2018. With respect to the four other indications, Editas may exercise the option until the fourth anniversary of the effective date, provided that the option will expire on the third anniversary of the effective date if Editas has not exercised the option with respect to the initial indication or any other indication by such date. Upon Editas’ timely exercise of the option with respect to the designated initial indication, Editas will pay the Company a $1.3 million fee. For the first additional indication for which Editas timely exercises its option, Editas will pay the Company a $1.5 million fee. Upon each subsequent exercise of the option, Editas will pay the Company a $1.0 million fee per Indication. If Editas elects to develop a product using certain of the Company’s proprietary vectors, the Company will be eligible to receive up to $15.5 million in development and commercialization milestone payments for such product, and tiered royalties between the mid-single digits and low teens on net sales of such product, subject to certain adjustments. Unless earlier terminated, the agreement will be in effect until the later of the expiration of the option exercise period or the expiration of the royalty term of the last product. At any time after the option is first exercised, Editas may terminate the agreement for convenience in its entirety or on an indication-by indication or country-by-country basis, upon prior written notice to the Company. The Company may also terminate the agreement if Editas challenges the Company’s patents relating to its proprietary vectors and does not withdraw such challenge within a defined period of time. In addition, either party may terminate the agreement with written notice upon a bankruptcy of the other party or upon an uncured material breach by the other party. Under Topic 606, the transaction price is $1.5 million related to the $1.0 million non-refundable upfront payment for license and research services at contract inception and the one-time, non-refundable cash payment of $0.5 million made by Editas in February 2018 in consideration for extending the agreement. The arrangement provides for additional payments to the Company when certain development and regulatory milestones are achieved. Since these milestone payments are not within the control of the Company and are not considered probable of being achieved until the events occur, the Company did not include them in the transaction price. The transaction price of $1.5 million was allocated to a single performance obligation, research and development. During the three months ended March 31, 2018, the Company recognized revenue of $0.2 million associated with Editas. The Company’s deferred revenue balance of $1.2 million as of March 31, 2018 was associated with Editas and is expected to be recognized over a period of six months as the research and development services are performed. |
Accrued Expenses and Other Curr
Accrued Expenses and Other Current Liabilities | 3 Months Ended |
Mar. 31, 2018 | |
Payables And Accruals [Abstract] | |
Accrued Expenses and Other Current Liabilities | 5. Accrued Expenses and Other Current Liabilities Accrued expenses and other current liabilities consist of the following: March 31, 2018 December (In thousands) Employee compensation $ 1,769 $ 2,259 Accrued preclinical costs 1,337 1,255 Accrued professional services 2,696 2,295 Accrued clinical and process development costs 826 910 Other 577 245 Total accrued expenses and other current liabilities $ 7,205 $ 6,964 |
Commitments and Contingencies
Commitments and Contingencies | 3 Months Ended |
Mar. 31, 2018 | |
Commitments And Contingencies Disclosure [Abstract] | |
Commitments and Contingencies | 6. Commitments and Contingencies Guarantees and Indemnifications In the normal course of business, the Company enters into contracts and agreements that contain a variety of representations and warranties and provide for indemnification for certain liabilities. The exposure under these agreements is unknown because it involves claims that may be made against the Company in the future but have not yet been made. Other than the obligations connected with the shareholder litigation described below, the Company has not paid any claims or been required to defend any action related to its indemnification obligations. However, the Company may record charges in the future as a result of these indemnification obligations. The Company also has indemnification obligations to its past and current directors and executive officers for specified events or occurrences, subject to some limits, while they were or are serving at the Company’s request in such capacities. Other than the obligations connected with the shareholder litigation described below, there have been no claims to date and the Company has not recorded any liabilities for these agreements as of March 31, 2018. Legal Proceedings From time to time, the Company may become involved in litigation and other legal actions. The Company estimates the range of liability related to any pending litigation where the amount and range of loss can be estimated. The Company records its best estimate of a loss when the loss is considered probable. Where a liability is probable and there is a range of estimated loss with no best estimate in the range, the Company records a charge equal to at least the minimum estimated liability for a loss contingency when both of the following conditions are met: (i) information available prior to issuance of the financial statements indicates that it is probable that a liability had been incurred at the date of the financial statements and (ii) the range of loss can be reasonably estimated. In July 2015, three securities class action lawsuits were filed against the Company and certain of its officers in the United States District Court for the Northern District of California (“U.S. District Court”), each on behalf of a purported class of investors who acquired the Company’s publicly traded securities between July 31, 2014 and June 15, 2015. The lawsuits asserted claims under the Securities Exchange Act of 1934, as amended (the “Exchange Act”) and Securities Act of 1933, as amended (the “Securities Act”) and alleged that the defendants made materially false and misleading statements and omitted allegedly material information related to, among other things, the Phase 2a clinical trial for AVA-101, a product candidate which is no longer being developed, and the prospects of AVA-101. The complaints sought unspecified damages, attorneys’ fees and other costs. In December 2015, a putative securities class action lawsuit was filed against the Company, the Company’s board of directors, underwriters of the Company’s January 13, 2015, follow-on public stock offering, and two of the Company’s institutional stockholders, in the Superior Court of the State of California for the County of San Mateo (“San Mateo Superior Court”). The complaint alleged that, in connection with the Company’s follow-on stock offering, the defendants violated the Securities Act by allegedly making materially false and misleading statements and by allegedly omitting material information related to the Phase 2a clinical trial for AVA- 101 and the prospects of AVA-101. The complaint also sought unspecified damages, attorneys’ fees and other costs. On March 16, 2017, the Company agreed to settle the actions and the settlements are now final. The total settlement amount paid was $13.0 million, of which $1.0 million was contributed by the Company to cover its indemnification obligations to the underwriters. The Company’s insurers paid the remainder. The Company and the defendants have denied and continue to deny the claims alleged in the actions, and the settlement does not assign or reflect any admission of fault, wrongdoing or liability as to any defendant. Notice of the settlement was provided to shareholders in the fall of 2017, and no shareholder objected to the settlement. On January 19, 2018, the San Mateo Superior Court entered a judgment and order finally approving the settlement. And on February 5, 2018, the U.S. District Court entered an order dismissing the consolidated federal action with prejudice. The Company recorded $1.0 million as general and administrative expense during the three months ended March 31, 2017, when the amount and time of settlement became estimable and probable. |
Equity Incentive Awards
Equity Incentive Awards | 3 Months Ended |
Mar. 31, 2018 | |
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract] | |
Equity Incentive Awards | 7. Equity Incentive Awards The following table summarizes the Company’s option activity and related information: Number of Options (in thousands) Weighted- Average Exercise Price Weighted- Average Remaining Contractual Life (in years) Aggregate Intrinsic Value (in thousands) Balance at December 31, 2017 6,695 $ 4.51 Options granted 1,364 6.40 Options exercised (1,362 ) 0.23 Options cancelled (14 ) 37.42 Balance at March 31, 2018 6,683 $ 5.70 8.2 $ 13,710 Exercisable as of March 31, 2018 2,324 $ 7.44 7.0 $ 5,497 Restricted Stock Units (“RSUs”) The following table summarizes the Company’s RSUs activity and related information: Number of Units (in thousands) Weighted- Average Grant- Date Fair Value Weighted- Average Remaining Contractual Term (in years) Outstanding at December 31, 2017 2,515 $ 3.24 1.6 Granted 672 6.19 Vested and released (329 ) 3.19 Forfeited (181 ) 4.49 Outstanding at March 31, 2018 2,677 $ 3.90 1.8 Stock-Based Compensation Expense The following table presents, by operating expense, the Company’s stock-based compensation expense: Three Months Ended March 31, 2018 2017 (In thousands) Research and development $ 2,378 $ 1,242 General and administrative 1,051 654 Total stock-based compensation expense $ 3,429 $ 1,896 |
Net Loss per Share
Net Loss per Share | 3 Months Ended |
Mar. 31, 2018 | |
Earnings Per Share [Abstract] | |
Net Loss per Share | 8. Net Loss per Share Basic net loss per share is calculated by dividing the net loss by the weighted-average number of shares of common stock outstanding for the period. Diluted net loss per share is computed by giving effect to all potential dilutive common stock equivalents outstanding for the period using the treasury stock method. Outstanding stock options, RSUs, employee stock purchase plan (“ESPP”) and warrants are considered to be common stock equivalents and are only included in the calculation of diluted net loss per share when their effect is dilutive. The Company excluded approximately 9.5 million and 9.9 million shares of potentially dilutive securities as of March 31, 2018 and 2017, respectively, from the computations of diluted weighted-shares outstanding because their effect would be anti-dilutive. |
Summary of significant accoun14
Summary of significant accounting policies (Policies) | 3 Months Ended |
Mar. 31, 2018 | |
Accounting Policies [Abstract] | |
Use of Estimates | Use of Estimates — The accompanying consolidated financial statements have been prepared in accordance with U.S. GAAP. The preparation of the consolidated financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities, disclosure of contingent liabilities and the reported amounts of expenses in the consolidated financial statements and the accompanying notes. On an ongoing basis, management evaluates its estimates, including those related to clinical trial accruals, fair value of assets and liabilities, income taxes, and stock-based compensation. Management bases its estimates on historical experience and on various other market-specific and relevant assumptions that management believes to be reasonable under the circumstances. Actual results could differ from those estimates. |
Accounting Standard Update Recently Adopted | Accounting Standard Updates Recently Adopted Accounting Standard Update (“ASU”) No. 2014-09, Revenue from Contracts with Customers (Topic 606), which supersedes the revenue recognition requirements in ASC 605, Revenue Recognition . Effective January 1, 2018, the Company adopted the new revenue standards under Topic 606 using the modified retrospective approach. Results for reporting periods beginning after January 1, 2018 are presented under Topic 606, while prior period results are not adjusted and continue to be reported in accordance with the revenue standards under Topic 605. Under ASC 606, the Company recognizes revenue when its customer obtains control of promised goods or services, in an amount that reflects the consideration which the Company expects to receive in exchange for those goods or services. To determine revenue recognition for arrangements that the Company determines are within the scope of ASC 606, the Company performs the following five steps: (i) identify the contract(s) with a customer; (ii) identify the performance obligations in the contract; (iii) determine the transaction price; (iv) allocate the transaction price to the performance obligations in the contract; and (v) recognize revenue when (or as) the Company satisfies a performance obligation. At contract inception, once the contract is determined to be within the scope of ASC 606, the Company assesses the goods or services promised within each contract and determines those that are performance obligations. The Company then recognizes as revenue the amount of the transaction price that is allocated to the respective performance obligation when (or as) the performance obligation is satisfied. The Company’s license and collaboration arrangements with Regeneron Pharmaceuticals, Inc. (“Regeneron”) and Editas Medicine, Inc. (“Editas”) are within the scope of Topic 606. Upon the adoption of Topic 606, the Company recorded a net decrease of $6.1 million to its deferred revenue and opening accumulated deficit as of January 1, 2018 for the cumulative effect of the adoption. The effect of the adoption is summarized for the Company’s license and collaboration agreements as follows: Collaboration Agreement with Regeneron — Under Topic 606, the transaction price at contract inception is $8.0 million related to the non-refundable upfront payment for license and research services. The arrangement also provides for additional payments to the Company when certain development and regulatory milestones are achieved. Since these milestone payments are not within the control of the Company and are not considered probable of being achieved until the events occur, the Company did not include them in the transaction price at contract inception. The transaction price of $8.0 million at contract inception was allocated to two performance obligations. The Company’s deferred revenue associated with its Regeneron collaboration agreement as of December 31, 2017 under Topic 605 was $6.5 million. As a result of adopting Topic 606, the Company recorded $6.5 million reduction to its deferred revenue and opening accumulated deficit during the three months ended March 31, 2018 as the performance obligations associated with the Regeneron deferred revenue were satisfied as of January 1, 2018. There was no outstanding deferred revenue associated with Regeneron as of March 31, 2018. Collaboration Agreement with Editas — Under Topic 606, the transaction price at contract inception is $1.0 million related to the non-refundable upfront payment for license and research services. The arrangement provides for additional payments to the Company when certain development and regulatory milestones are achieved. Since these milestone payments are not within the control of the Company and are not considered probable of being achieved until the events occur, the Company did not include them in the transaction price at contract inception. The transaction price of $1.0 million was allocated to a single performance obligation. The Company’s deferred revenue associated with its Editas collaboration agreement as of December 31, 2017 under Topic 605 was $0.5 million. As a result of adopting Topic 606, the Company recorded an increase of $0.4 million to its deferred revenue and opening accumulated deficit during the three months ended March 31, 2018 due to differences in the timing of recognition under Topic 606. Under Topic 605, the Company’s revenue for the three months March 31, 2018 would have been $0.5 million. |
Recently-Issued and Not Yet Adopted Accounting Pronouncements | Recently-Issued and Not Yet Adopted Accounting Pronouncements In February 2016, the Financial Accounting Standards Board (“FASB”) issued ASU No. 2016-2, Leases, which amends the current guidance on leasing activities to provide more transparency and comparability, and requires that all leases be recognized by lessees on their balance sheet as a right-of-use asset and corresponding lease liability, which are currently accounted for as operating leases. The new standard is effective for fiscal years and interim periods within those fiscal years beginning after December 15, 2018, with early adoption permitted. This ASU will be effective for the Company in the first quarter of 2019 and must be adopted using a modified retrospective transition approach. The Company is currently evaluating the impact of the adoption of this standard on its consolidated financial statements and related disclosures. |
Fair Value Measurements and F15
Fair Value Measurements and Fair Value of Financial Instruments (Tables) | 3 Months Ended |
Mar. 31, 2018 | |
Fair Value Disclosures [Abstract] | |
Summary of Cash Equivalents and Short-term Investments | The following is a summary of the Company’s cash equivalents and short-term investments as of March 31, 2018: March 31, 2018 Amortized Cost Basis Unrealized Gains Unrealized Loses Estimated Fair Value (In thousands) Level 1: Money market funds $ 59 $ — $ — $ 59 Level 2: U.S. government and agency securities 38,278 — (135 ) 38,143 Commercial paper 159,844 — — 159,844 Corporate bonds 32,797 — (30 ) 32,767 Certificates of deposit 7,836 — — 7,836 Total cash equivalents and short-term investments 238,814 — (165 ) 238,649 Less: cash equivalents (144,329 ) — 1 (144,328 ) Total short-term investments $ 94,485 $ — $ (164 ) $ 94,321 The following is a summary of the Company’s cash equivalents and short-term investments as of December 31, 2017: December 31, 2017 Amortized Cost Basis Unrealized Gains Unrealized Loses Estimated Fair Value (In thousands) Level 1: Money market funds $ 65 $ — $ — $ 65 Level 2: U.S. government and agency securities 58,351 — (145 ) 58,206 Commercial paper 71,427 — — 71,427 Corporate bonds 38,354 1 (38 ) 38,317 Certificates of deposit 9,731 — — 9,731 Total cash equivalents and short-term investments 177,928 1 (183 ) 177,746 Less: cash equivalents (57,780 ) — — (57,780 ) Total short-term investments $ 120,148 $ 1 $ (183 ) $ 119,966 |
Accrued Expenses and Other Cu16
Accrued Expenses and Other Current Liabilities (Tables) | 3 Months Ended |
Mar. 31, 2018 | |
Payables And Accruals [Abstract] | |
Schedule of Accrued Expenses and Other Current Liabilities | Accrued expenses and other current liabilities consist of the following: March 31, 2018 December (In thousands) Employee compensation $ 1,769 $ 2,259 Accrued preclinical costs 1,337 1,255 Accrued professional services 2,696 2,295 Accrued clinical and process development costs 826 910 Other 577 245 Total accrued expenses and other current liabilities $ 7,205 $ 6,964 |
Equity Incentive Awards (Tables
Equity Incentive Awards (Tables) | 3 Months Ended |
Mar. 31, 2018 | |
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract] | |
Summary of Stock Options Activity | The following table summarizes the Company’s option activity and related information: Number of Options (in thousands) Weighted- Average Exercise Price Weighted- Average Remaining Contractual Life (in years) Aggregate Intrinsic Value (in thousands) Balance at December 31, 2017 6,695 $ 4.51 Options granted 1,364 6.40 Options exercised (1,362 ) 0.23 Options cancelled (14 ) 37.42 Balance at March 31, 2018 6,683 $ 5.70 8.2 $ 13,710 Exercisable as of March 31, 2018 2,324 $ 7.44 7.0 $ 5,497 |
Summary of Restricted Stock Units Activity | The following table summarizes the Company’s RSUs activity and related information: Number of Units (in thousands) Weighted- Average Grant- Date Fair Value Weighted- Average Remaining Contractual Term (in years) Outstanding at December 31, 2017 2,515 $ 3.24 1.6 Granted 672 6.19 Vested and released (329 ) 3.19 Forfeited (181 ) 4.49 Outstanding at March 31, 2018 2,677 $ 3.90 1.8 |
Stock-Based Compensation Expense | The following table presents, by operating expense, the Company’s stock-based compensation expense: Three Months Ended March 31, 2018 2017 (In thousands) Research and development $ 2,378 $ 1,242 General and administrative 1,051 654 Total stock-based compensation expense $ 3,429 $ 1,896 |
Organization and Basis of Pre18
Organization and Basis of Presentation - Additional Information (Detail) - USD ($) $ in Thousands | 1 Months Ended | 3 Months Ended | ||
Feb. 28, 2018 | Jan. 31, 2018 | Mar. 31, 2018 | Dec. 31, 2017 | |
Class of Stock [Line Items] | ||||
Date of incorporation | Jul. 17, 2006 | |||
Change of entity name date | May 11, 2016 | |||
Accumulated deficit | $ (265,116) | $ (254,062) | ||
Net proceeds from issuance of common stock | $ 70,191 | |||
Underwritten Public Offering [Member] | ||||
Class of Stock [Line Items] | ||||
Issuance of common stock | 10,222,235 | |||
Net proceeds from issuance of common stock | $ 64,500 | |||
2017 Stock Offering Agreement [Member] | ||||
Class of Stock [Line Items] | ||||
Issuance of common stock | 1,419,893 | 0 | ||
Net proceeds from issuance of common stock | $ 5,700 |
Summary of Significant Accoun19
Summary of Significant Accounting Policies - Additional Information (Detail) - USD ($) $ in Thousands | 1 Months Ended | 3 Months Ended | ||||
Aug. 31, 2016 | May 31, 2014 | Mar. 31, 2018 | Mar. 31, 2017 | Jan. 01, 2018 | Dec. 31, 2017 | |
Summary Of Significant Accounting Policies [Line Items] | ||||||
Retained earnings (accumulated deficit) | $ (265,116) | $ (254,062) | ||||
Collaboration and license revenue | 216 | $ 462 | ||||
Regeneron Corporation [Member] | ||||||
Summary Of Significant Accounting Policies [Line Items] | ||||||
Deferred revenue | 0 | |||||
Accounting Standards Update 2014-09 [Member] | Regeneron Corporation [Member] | Upfront Payment Arrangement [Member] | ||||||
Summary Of Significant Accounting Policies [Line Items] | ||||||
Initial payments received | $ 8,000 | |||||
Revenue remaining performance obligation | $ 8,000 | |||||
Accounting Standards Update 2014-09 [Member] | Editas Medicine Inc [Member] | Upfront Payment Arrangement [Member] | ||||||
Summary Of Significant Accounting Policies [Line Items] | ||||||
Initial payments received | $ 1,000 | |||||
Revenue remaining performance obligation | $ 1,000 | |||||
Difference between Revenue Guidance in Effect before and after Topic 606 [Member] | Accounting Standards Update 2014-09 [Member] | ||||||
Summary Of Significant Accounting Policies [Line Items] | ||||||
Retained earnings (accumulated deficit) | $ 6,100 | |||||
Deferred revenue | $ (6,100) | |||||
Difference between Revenue Guidance in Effect before and after Topic 606 [Member] | Accounting Standards Update 2014-09 [Member] | Regeneron Corporation [Member] | ||||||
Summary Of Significant Accounting Policies [Line Items] | ||||||
Retained earnings (accumulated deficit) | 6,500 | |||||
Deferred revenue | (6,500) | |||||
Difference between Revenue Guidance in Effect before and after Topic 606 [Member] | Accounting Standards Update 2014-09 [Member] | Editas Medicine Inc [Member] | ||||||
Summary Of Significant Accounting Policies [Line Items] | ||||||
Retained earnings (accumulated deficit) | (400) | |||||
Deferred revenue | 400 | |||||
Calculated under Revenue Guidance in Effect before Topic 606 [Member] | Editas Medicine Inc [Member] | ||||||
Summary Of Significant Accounting Policies [Line Items] | ||||||
Collaboration and license revenue | $ 500 | |||||
Calculated under Revenue Guidance in Effect before Topic 606 [Member] | Accounting Standards Update 2014-09 [Member] | Regeneron Corporation [Member] | ||||||
Summary Of Significant Accounting Policies [Line Items] | ||||||
Deferred revenue | 6,500 | |||||
Calculated under Revenue Guidance in Effect before Topic 606 [Member] | Accounting Standards Update 2014-09 [Member] | Editas Medicine Inc [Member] | ||||||
Summary Of Significant Accounting Policies [Line Items] | ||||||
Deferred revenue | $ 500 |
Fair Value Measurements and F20
Fair Value Measurements and Fair Value of Financial Instruments - Summary of Cash Equivalents and Short-term Investments (Detail) - USD ($) $ in Thousands | Mar. 31, 2018 | Dec. 31, 2017 |
Schedule Of Available For Sale Securities [Line Items] | ||
Amortized Cost Basis | $ 94,485 | $ 120,148 |
Unrealized Gains | 1 | |
Unrealized Loses | (164) | (183) |
Estimated Fair Value | 94,321 | 119,966 |
Less: Cash Equivalents, Amortized Cost Basis | (144,329) | (57,780) |
Less: Cash Equivalents, Unrealized Gains | 0 | 0 |
Less: Cash Equivalents, Unrealized Loses | 1 | 0 |
Less: Cash Equivalents, Estimated Fair Value | (144,328) | (57,780) |
Money Market Funds [Member] | Quoted Prices in Active Markets (Level 1) [Member] | ||
Schedule Of Available For Sale Securities [Line Items] | ||
Amortized Cost Basis | 59 | 65 |
Estimated Fair Value | 59 | 65 |
Certificates of Deposit [Member] | Significant Other Observable Inputs (Level 2) [Member] | ||
Schedule Of Available For Sale Securities [Line Items] | ||
Amortized Cost Basis | 7,836 | 9,731 |
Estimated Fair Value | 7,836 | 9,731 |
Commercial Paper [Member] | Significant Other Observable Inputs (Level 2) [Member] | ||
Schedule Of Available For Sale Securities [Line Items] | ||
Amortized Cost Basis | 159,844 | 71,427 |
Estimated Fair Value | 159,844 | 71,427 |
U.S. Government Agency Securities [Member] | Significant Other Observable Inputs (Level 2) [Member] | ||
Schedule Of Available For Sale Securities [Line Items] | ||
Amortized Cost Basis | 38,278 | 58,351 |
Unrealized Loses | (135) | (145) |
Estimated Fair Value | 38,143 | 58,206 |
Corporate Bonds [Member] | Significant Other Observable Inputs (Level 2) [Member] | ||
Schedule Of Available For Sale Securities [Line Items] | ||
Amortized Cost Basis | 32,797 | 38,354 |
Unrealized Gains | 1 | |
Unrealized Loses | (30) | (38) |
Estimated Fair Value | 32,767 | 38,317 |
Total Cash Equivalents and Short-term Investments [Member] | ||
Schedule Of Available For Sale Securities [Line Items] | ||
Amortized Cost Basis | 238,814 | 177,928 |
Unrealized Gains | 1 | |
Unrealized Loses | (165) | (183) |
Estimated Fair Value | $ 238,649 | $ 177,746 |
Fair Value Measurements and F21
Fair Value Measurements and Fair Value of Financial Instruments - Additional Information (Detail) - USD ($) | 3 Months Ended | |
Mar. 31, 2018 | Dec. 31, 2017 | |
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] | ||
Liabilities transferred within Level 3 | $ 0 | |
Gross unrealized losses on available-for-sale-securities temporary | 200,000 | |
Marketable securities other-than-temporarily impaired | 0 | |
The Alpha-1 Project, Inc. [Member] | Significant Unobservable Inputs (Level 3) [Member] | ||
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items] | ||
Proceeds from financing arrangement | $ 200,000 | $ 200,000 |
Significant Agreements - Additi
Significant Agreements - Additional Information (Detail) - USD ($) | 1 Months Ended | 3 Months Ended | |||
Feb. 28, 2018 | Aug. 31, 2016 | Mar. 31, 2018 | Mar. 31, 2017 | Dec. 31, 2017 | |
License Agreement [Line Items] | |||||
Revenue recognized | $ 216,000 | $ 462,000 | |||
Deferred revenue | $ 1,246,000 | $ 1,850,000 | |||
Editas Medicine Inc [Member] | |||||
License Agreement [Line Items] | |||||
Initial payments received | $ 500,000 | ||||
Collaboration, option and license agreement fee receivable per indication | $ 1,000,000 | ||||
Range of tiered royalties receivable on net sales | between the mid-single digits and low teens | ||||
Revenue recognized | $ 216,000 | ||||
Deferred revenue | $ 1,200,000 | ||||
Revenue recognition, expected time period | 6 months | ||||
Editas Medicine Inc [Member] | Topic 606 [Member] | |||||
License Agreement [Line Items] | |||||
Initial payments received | $ 500,000 | ||||
Collaboration, option and license agreement fee receivable per indication | 1,500,000 | ||||
Non-refundable upfront payment received | 1,000,000 | ||||
Editas Medicine Inc [Member] | Initial Indication [Member] | |||||
License Agreement [Line Items] | |||||
Collaboration, option and license agreement fee receivable per indication | 1,300,000 | ||||
Editas Medicine Inc [Member] | Additional Indication [Member] | |||||
License Agreement [Line Items] | |||||
Collaboration, option and license agreement fee receivable per indication | 1,500,000 | ||||
Editas Medicine Inc [Member] | Maximum [Member] | |||||
License Agreement [Line Items] | |||||
Potential milestone earnings | $ 15,500,000 |
Accrued Expenses and Other Cu23
Accrued Expenses and Other Current Liabilities - Schedule of Accrued Expenses and Other Current Liabilities (Detail) - USD ($) $ in Thousands | Mar. 31, 2018 | Dec. 31, 2017 |
Accrued Expenses And Other Current Liabilities [Abstract] | ||
Employee compensation | $ 1,769 | $ 2,259 |
Accrued preclinical costs | 1,337 | 1,255 |
Accrued professional services | 2,696 | 2,295 |
Accrued clinical and process development costs | 826 | 910 |
Other | 577 | 245 |
Total accrued expenses and other current liabilities | $ 7,205 | $ 6,964 |
Commitments and Contingencies -
Commitments and Contingencies - Additional Information (Detail) | Mar. 16, 2017USD ($) | Dec. 31, 2015Claim | Jul. 31, 2015Claim | Mar. 31, 2018USD ($)Claim | Mar. 31, 2017USD ($) |
Other Commitments [Line Items] | |||||
Claims paid to date related to indemnification issues | $ 13,000,000 | $ 0 | |||
Number of claims to date | Claim | 1 | 3 | 0 | ||
Accruals or expenses related to indemnification issues | $ 0 | ||||
General and administrative expense | $ 5,368,000 | $ 7,989,000 | |||
Indemnification Obligations [Member] | |||||
Other Commitments [Line Items] | |||||
Claims paid to date related to indemnification issues | $ 1,000,000 | ||||
General and administrative expense | $ 1,000,000 |
Equity Incentive Awards - Summa
Equity Incentive Awards - Summary of Stock Options Activity (Detail) $ / shares in Units, $ in Thousands | 3 Months Ended |
Mar. 31, 2018USD ($)$ / sharesshares | |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Nonvested, Options Outstanding [Roll Forward] | |
Number of Options, Beginning Balance | shares | 6,695,000 |
Number of Options, Options granted | shares | 1,364,000 |
Number of Options, Options exercised | shares | (1,362,000) |
Number of Options, Options cancelled | shares | (14,000) |
Number of Options, Ending Balance | shares | 6,683,000 |
Number of Options, Exercisable | shares | 2,324,000 |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Abstract] | |
Weighted-Average Exercise Price, Beginning Balance | $ / shares | $ 4.51 |
Weighted-Average Exercise Price, Options granted | $ / shares | 6.40 |
Weighted-Average Exercise Price, Options exercised | $ / shares | 0.23 |
Weighted-Average Exercise Price, Options cancelled | $ / shares | 37.42 |
Weighted-Average Exercise Price, Ending Balance | $ / shares | 5.70 |
Weighted-Average Exercise Price, Exercisable | $ / shares | $ 7.44 |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Additional Disclosures [Abstract] | |
Weighted-Average Remaining Contractual Life (In years) | 8 years 2 months 12 days |
Weighted-Average Remaining Contractual Life (In years), Exercisable | 7 years |
Aggregate Intrinsic Value, Options outstanding | $ | $ 13,710 |
Aggregate Intrinsic Value, Exercisable | $ | $ 5,497 |
Equity Incentive Awards - Sum26
Equity Incentive Awards - Summary of Restricted Stock Units Activity (Detail) - Restricted Stock Units [Member] - $ / shares | 3 Months Ended | 12 Months Ended |
Mar. 31, 2018 | Dec. 31, 2017 | |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | ||
Number of Units, Beginning Balance | 2,515,000 | |
Number of Units, Granted | 672,000 | |
Number of Units, Vested and released | (329,000) | |
Number of Units, Forfeited | (181,000) | |
Number of Units, Ending Balance | 2,677,000 | 2,515,000 |
Weighted-Average Grant-Date Fair Value, Beginning Balance | $ 3.24 | |
Weighted-Average Grant-Date Fair Value, Granted | 6.19 | |
Weighted-Average Grant-Date Fair Value, Vested and released | 3.19 | |
Weighted-Average Grant-Date Fair Value, Forfeited | 4.49 | |
Weighted-Average Grant-Date Fair Value, Ending Balance | $ 3.90 | $ 3.24 |
Weighted-Average Remaining Contractual Term (In years) | 1 year 9 months 18 days | 1 year 7 months 6 days |
Equity Incentive Awards - Stock
Equity Incentive Awards - Stock-Based Compensation Expense (Detail) - USD ($) $ in Thousands | 3 Months Ended | |
Mar. 31, 2018 | Mar. 31, 2017 | |
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] | ||
Total stock-based compensation expense | $ 3,429 | $ 1,896 |
Research and Development [Member] | ||
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] | ||
Total stock-based compensation expense | 2,378 | 1,242 |
General and Administrative [Member] | ||
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] | ||
Total stock-based compensation expense | $ 1,051 | $ 654 |
Net Loss per Share - Additional
Net Loss per Share - Additional Information (Detail) - shares shares in Millions | 3 Months Ended | |
Mar. 31, 2018 | Mar. 31, 2017 | |
Earnings Per Share [Abstract] | ||
Antidilutive common stock equivalents excluded from calculation of diluted net loss per share | 9.5 | 9.9 |