Exhibit 23.1
Consent of Independent Registered Public Accounting Firm
We consent to the reference to our firm under the caption “Experts” in Amendment No. 1 to the Registration Statement (Form S-3 No. 333-194293) and related Prospectus of Regulus Therapeutics Inc. for the registration of common stock and warrants and to the incorporation by reference therein of our report dated February 27, 2014, with respect to the financial statements of Regulus Therapeutics Inc. included in its Annual Report (Form 10-K) for the year ended December 31, 2013, filed with the Securities and Exchange Commission.
/s/ Ernst & Young LLP
San Diego, California
April 11, 2014
