Exhibit 23.1
Consent of Independent Registered Public Accounting Firm
We consent to the reference to our firm under the caption “Experts” this Registration Statement(Form S-3) and related Prospectus of Regulus Therapeutics Inc. for the registration of common stock, preferred stock, warrants and debt securities, and to the incorporation by reference therein of our report dated March 2, 2017, with respect to the financial statements of Regulus Therapeutics Inc., included in its Annual Report (Form10-K) for the year ended December 31, 2016, filed with the Securities and Exchange Commission.
/s/ Ernst & Young LLP
San Diego, California
January 29, 2018
