Exhibit 99.4

ASX/Media Release (Code: ASX: IMM; NASDAQ: IMMP)
Immutep Announces US$5.2 Million Financing Led by U.S. Specialist Healthcare Investor, Altium Capital
- - -
| • | | Extends the Company’s cash runway intomid-2020, during which time Immutep is expected to report meaningful clinical data |
SYDNEY, AUSTRALIA – December 19, 2018 –Immutep Limited (ASX: IMM; NASDAQ: IMMP) (“Immutep“ or “the Company“), a biotechnology company developing novel immunotherapy treatments for cancer and autoimmune diseases, today announces it has entered into a securities purchase agreement (the “Purchase Agreement”) with certain accredited investors to purchase 260,000,000 ordinary shares represented by 2,600,000 American Depositary Shares (“ADSs”) at a purchase price per ADS of US$2.00 in a registered direct offering, for total gross proceeds of approximately US$5.2 million (equivalent to A$7.2 million). In a concurrent private placement, the Company has agreed to issue warrants to purchase up to 208,000,000 ordinary shares represented by 2,080,000 ADSs. The warrants will have an exercise price of US$2.50 per ADS and will be exercisable immediately following the close of this private placement and will expire three years from the date of effectiveness of the registration statement registering for resale the ordinary shares underlying the warrants. The registered direct offering is being led by Altium Capital, a U.S.-based healthcare investment fund founded by CEO, Jacob Gottlieb, with participation from another investor.
The proceeds from the financing are expected to extend Immutep’s cash runway intomid-2020. Immutep intends to use the net proceeds from this offering to continue itsLAG-3 related programs, especially the ongoing clinical development of eftilagimod alpha (“efti” or “IMP321”), including the AIPAC, TACTI-mel,TACTI-002, and INSIGHT clinical studies, as well as the preclinical development of IMP761, and general corporate purposes.
Immutep’s CEO, Marc Voigt, commented, “We are pleased to have Altium Capital lead this financing. Altium joins a growing number of specialist healthcare funds we have welcomed as investors in Immutep over the past year, as they recognize Immutep is leading the excitement aroundLAG-3. This financing, raised in a difficult market environment, has extended Immutep’s cash runway beyond the estimated AIPAC data readout in H2 2019, as well as potential meaningful data points from our ongoing and planned TACTI clinical studies.”
Jacob Gottlieb, Altium Capital’s CEO, commented, “The potential therapeutic relevance ofLAG-3 is becoming increasing appreciated within both the biopharma industry and the investment community. Immutep has already established itself as a clear leader in the understanding of theLAG-3 immune control mechanism, having built partnerships with five of the world’s largest pharmaceutical companies and operating under the research direction of Dr. Frederic Triebel.”
“We are pleased to have the opportunity to support Immutep’s innovative clinical and preclinical product candidates. We have a particular interest in the potential of IMP761, its preclinical agonist antibody for autoimmune diseases. This investment is consistent with our fundamental long-term investment strategy,” Gottlieb concluded.